assoc_id FEATURE Drug id Drug name Drug Target N_FEATURE_pos N_FEATURE_neg log max.Conc.tested log max.Conc.tested2 FEATUREpos_logIC50_MEAN FEATUREneg_logIC50_MEAN FEATURE_deltaMEAN_IC50 FEATUREpos_IC50_sd FEATUREneg_IC50_sd FEATURE_IC50_effect_size FEATUREpos_Glass_delta FEATUREneg_Glass_delta FEATURE_ANOVA_pval Tissue_ANOVA_pval MEDIA_ANOVA_pval MSI_ANOVA_pval FEATURE_IC50_T_pval ANOVA FEATURE FDR % a1 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1377 Afatinib (rescreen) ERBB2, EGFR 15 32 2.30258509299405 NA 0.704496002352464 3.83314518983875 -3.12864918748628 1.29662110679853 1.35754088201208 2.33675698867874 2.41292477122418 2.30464454436846 2.0745496704267e-09 NA NA NA 2.43146489164488e-08 0.00240212106338708 a2 gain_cnaBRCA27_(CLTC,PPM1D) 119 Lapatinib ERBB2, EGFR 3 10 0.693147180559945 NA -2.2037155582255 2.53601593552623 -4.73973149375173 1.0232130123674 0.777649802265438 5.72615168694359 4.63220408308283 6.09494335360726 2.92140511123018e-06 NA NA NA 0.00693112717667035 1.69134748914671 a3 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 255 CP724714 ERBB2 14 34 2.32630161961136 NA 2.26543188072345 4.43616666354153 -2.17073478281808 1.99417861438789 0.978499811622581 1.61316540006574 1.08853578468666 2.21843147748643 6.71788221654285e-06 NA NA NA 0.00136516575791772 1.95955497870861 a4 gain_cnaBRCA30_(CRNKL1,FOXA2) 204 Tipifarnib Farnesyl-transferase (FNTA) 5 43 2.77258872223978 NA 4.24473105967931 1.31477251213179 2.92995854754752 1.75646109856647 1.15740065321527 2.39921622356297 1.668103295848 2.53149895795208 6.76934097489805e-06 NA NA NA 0.0185418507761689 1.95955497870861 a5 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 7 39 1.63315443905142 NA 4.08902164453232 1.55026198164388 2.53875966288844 1.11923708619922 1.33327661728777 1.94368736172717 2.2682948002641 1.9041507440916 2.30066450205407e-05 NA NA NA 0.000402269833859235 5.08044918023795 a6 loss_cnaBRCA33 206 Ruxolitinib JAK1, JAK2, TYK2 6 43 1.65632149833295 0.0237165266173161 3.40009542015439 4.50563231728577 -1.10553689713138 0.850989080647079 0.495455370442747 2.0306379762463 1.2991199561465 2.2313551594838 2.63258442710318e-05 NA NA NA 0.0234952646099267 5.08044918023795 a7 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1032 Afatinib ERBB2, EGFR 15 30 -0.693147180559945 NA -1.17873702309413 1.02507605913977 -2.2038130822339 1.59735519439136 1.46628641072646 1.45927653089053 1.37966376543673 1.50298950199098 3.53726733123677e-05 NA NA NA 0.000131410445759692 5.85114548977008 a8 loss_cnaBRCA34 1011 ABT-263 BCL2, BCL2L1, BCL2L2 5 38 0.693147180559945 NA -0.937052955629938 2.02655228181729 -2.96360523744722 1.81167385243135 1.32053388044747 2.15348894458009 1.63583816892313 2.24424778593563 5.06475537986751e-05 NA NA NA 0.0192706582413037 7.33060031793574 a9 ASH1L_mut 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 3 44 2.77258872223978 NA 2.94129406788369 5.15201107939621 -2.21071701151252 1.34189077162105 0.844483580847429 2.53338970650254 1.64746420369364 2.61783303032853 0.000107712053238059 NA NA NA 0.100223488163966 13.8577540493721 a10 gain_cnaBRCA47_(EGFR) 1114 Cetuximab EGFR 6 39 4.18661983833127 NA 5.09781540137732 6.46485730955704 -1.36704190817972 1.32693041533767 0.631329897347578 1.83175059345072 1.03022878395009 2.16533687684221 0.000141629428517029 NA NA NA 0.0525855754970419 16.0828864444125 a11 gain_cnaBRCA30_(CRNKL1,FOXA2) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 4 41 -0.669430653942629 NA 0.616799690001327 -3.88648331268522 4.50328300268655 2.01376693803609 2.07482715593871 2.17484178038576 2.23624835507446 2.17043766262502 0.000153188850930792 NA NA NA 0.0158792878205334 16.0828864444125 a12 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 119 Lapatinib ERBB2, EGFR 4 9 0.693147180559945 NA -1.30590167254154 2.663624374528 -3.96952604706954 1.98046854870921 0.705079844881875 3.3180221625482 2.00433682708909 5.62989578539799 0.000180302764863269 NA NA NA 0.024543809236502 16.0828864444125 a13 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 204 Tipifarnib Farnesyl-transferase (FNTA) 7 41 2.77258872223978 NA 3.48110606130587 1.30222270465665 2.17888335664922 1.87277381896197 1.20025992863259 1.66614217677427 1.16345248667398 1.81534291420654 0.000180566131598033 NA NA NA 0.0211129358421193 16.0828864444125 a14 ASH1L_mut 170 Shikonin unknown 3 44 2.77258872223978 NA -2.304052759797 0.160948513945305 -2.46500127374231 0.215537236297788 1.04765362271288 2.40460856217603 11.4365448684544 2.35287810808999 0.000212591679378882 NA NA NA 3.298708375423e-08 17.5828503966291 a15 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1003 Camptothecin TOP1 15 30 -2.30258509299405 NA -1.37346649401608 -3.10718891903606 1.73372242501998 1.73854997849953 1.1430861018901 1.26941480823366 0.997223229967936 1.51670326684339 0.000234576692537811 NA NA NA 0.00221147772815353 17.7869949533143 a16 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 53 CGP-60474 CDK1,CDK2,CDK5,CDK7,CDK9 3 9 -1.36257783450257 NA 0.441520550864706 -2.41412980632886 2.85565035719357 1.20008895377886 0.621174098653165 3.69672069394813 2.37953224067404 4.59718195492248 0.000245782813069375 NA NA NA 0.0440948501631578 17.7869949533143 a17 gain_cnaBRCA27_(CLTC,PPM1D) 255 CP724714 ERBB2 9 39 2.32630161961136 NA 2.07701619078874 4.20134787624209 -2.12433168545336 2.43894503338208 1.14057726969619 1.46273321557114 0.871004330305692 1.86250571696839 0.000261880379001075 NA NA NA 0.0316950672771475 17.8371347556085 a18 loss_cnaBRCA33 312 AV-951 VEGFR 6 42 -2.05572501506252 NA -0.20700269461975 0.752172783136365 -0.959175477756114 0.774240053892138 0.527272153747424 1.71457980901883 1.23886057422927 1.8191278847917 0.000284720246521081 NA NA NA 0.0277167674487722 18.3154207470422 a19 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 41 S-Trityl-L-cysteine KIF11 3 9 1.63315443905142 NA 3.52599596634945 0.456862474693055 3.0691334916564 0.760098869263568 0.889713397312871 3.54671654045527 4.03780825858874 3.44957544859485 0.000337711457827691 NA NA NA 0.0042970171746755 19.298277458493 a20 POLR2B_mut 1218 JQ1 BRD2, BRD3, BRD4 3 43 0 NA 1.13334760521881 2.55039821620186 -1.41705061098305 0.362831786214919 0.619873590067594 2.32097129586193 3.90553050978748 2.28603159368111 0.00033860894694023 NA NA NA 0.00955193738624529 19.298277458493 a21 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 88 MS-275 HDAC 5 9 1.6094379124341 NA 2.98973106869538 0.111084152521586 2.87864691617379 1.51966064786057 0.732041623206788 2.71154961286345 1.89426956618667 3.93235415161718 0.000390635436829857 NA NA NA 0.0102309802984138 19.298277458493 a22 gain_cnaBRCA31 1268 XAV 939 TNKS1 (tankyrase-1) 15 32 1.6094379124341 NA 4.33222969695456 3.34701127427376 0.985218422680797 0.755617316132179 0.850264383606024 1.19858107386833 1.30385897946846 1.15872008951195 0.000393723985332775 NA NA NA 0.000370234584242491 19.298277458493 a23 gain_cnaBRCA62 301 PHA-793887 CDK-pan 10 38 2.32630161961136 NA 1.37653837488676 3.32904136174129 -1.95250298685453 1.86504093028621 1.31915983647526 1.35373123132641 1.0468955158828 1.48011100161413 0.000411997985519319 NA NA NA 0.00943391170983562 19.298277458493 a24 gain_cnaBRCA48 235 QL-XII-47 BTK, BMX 5 44 2.32630161961136 NA 3.83753190770531 1.46609136608373 2.37144054162159 1.15996012456728 1.34071203265173 1.7880279907756 2.04441557204929 1.76879186869922 0.000430122416823656 NA NA NA 0.00705468205573628 19.298277458493 a25 CDH1_mut 150 Bicalutamide ANDR (androgen receptor) 4 44 0.0237165266173161 NA 1.7673218764244 2.8530664586371 -1.08574458221269 0.40512092588136 0.55693298762231 1.98014776422947 2.68005060427477 1.94950668454389 0.000434358133327367 NA NA NA 0.00722093297421286 19.298277458493 a26 gain_cnaBRCA30_(CRNKL1,FOXA2) 140 Vinorelbine Microtubules 5 42 -2.74887219562247 NA -1.28311740795823 -3.87561469998721 2.59249729202898 1.32680491031011 1.45488844290023 1.79540376914762 1.95394007957284 1.78192170312454 0.000438473797038972 NA NA NA 0.00867328024874893 19.298277458493 a27 PTEN_mut 1030 KU-55933 ATM 5 37 2.30258509299405 NA 2.94441639988765 4.39498624088035 -1.45056984099271 0.514269804359384 0.821496055642241 1.82203417463863 2.82063972781691 1.76576604480305 0.000449998697106236 NA NA NA 0.000905699581701392 19.298277458493 a28 gain_cnaBRCA30_(CRNKL1,FOXA2) 1375 Temozolomide DNA akylating agent 5 41 3.40119738166216 NA 6.87498619299282 5.78124053815114 1.09374565484169 0.714493279015051 0.600172273131158 1.78877668523806 1.5307990809227 1.8223861777811 0.000473967440992919 NA NA NA 0.0238227630973966 19.3965440398558 a29 gain_cnaBRCA30_(CRNKL1,FOXA2) 201 Epothilone B Microtubules 5 43 -3.44201937618241 NA -1.71257042368847 -4.52915182024802 2.81658139655956 1.47726319874519 1.60216799698629 1.76954748105135 1.90662124322328 1.75798131148394 0.000500826023733929 NA NA NA 0.00969863049925375 19.3965440398558 a30 ASH1L_mut 167 OSU-03012 PDPK1 (PDK1) 3 45 2.77258872223978 NA 0.0619646556159493 2.39371331904886 -2.33174866343291 1.26998097022927 1.03305460480152 2.23246236081082 1.83605008113781 2.25713979938255 0.000502544538557453 NA NA NA 0.0802903249803385 19.3965440398558 a31 gain_cnaBRCA30_(CRNKL1,FOXA2) 1268 XAV 939 TNKS1 (tankyrase-1) 5 42 1.6094379124341 NA 4.96711838399533 3.50600510264529 1.46111328135005 0.792821350998542 0.830294586280959 1.76669414399913 1.84292877520239 1.75975287023686 0.000527218424060375 NA NA NA 0.0112363851253949 19.6924584909519 a32 gain_cnaBRCA30_(CRNKL1,FOXA2) 167 OSU-03012 PDPK1 (PDK1) 5 43 2.77258872223978 NA 3.88888487273711 2.05717602233398 1.83170885040313 1.31078104001519 1.01855868043 1.74912990994196 1.39741787108998 1.79833414175985 0.000571105769226777 NA NA NA 0.0328914790725156 20.6651053183652 a33 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 184 BMS-754807 IGF1R 7 41 0.940007258491471 NA 3.53690123217706 1.30076588291206 2.23613534926499 0.911589972343266 1.55486410244759 1.50396498043976 2.45300564629616 1.43815484951063 0.000614734568750419 NA NA NA 0.000144096174008734 21.5141603523215 a34 loss_cnaBRCA18 275 I-BET BRD2, BRD3, BRD4 16 33 2.99573227355399 NA 3.13213192809353 4.47860609265942 -1.34647416456588 1.05374111010961 1.27404580743915 1.11453088312892 1.27780358158924 1.05684909969785 0.000639973373107315 NA NA NA 0.000398681048351112 21.5141603523215 a35 gain_cnaBRCA64_(SDHC) 224 AS605240 PI3Kgamma 8 41 2.99573227355399 2.32630161961136 1.61231800000606 3.59375699309319 -1.98143899308713 2.53109151678835 1.09609503617724 1.40934472949106 0.78283972742374 1.80772554175378 0.000664130339695808 NA NA NA 0.063496061056555 21.5141603523215 a36 gain_cnaBRCA31 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 13 30 1.6094379124341 NA 4.0684834191514 2.45945664134242 1.60902677780899 0.84943229358901 1.46637771245595 1.22257888835253 1.89423782207591 1.09727989190052 0.000668891763264162 NA NA NA 6.2192823264788e-05 21.5141603523215 a37 gain_cnaBRCA62 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 7 36 -1.38629436111989 0.693147180559945 -1.1623525696239 -2.42626420752401 1.26391163790011 0.981616783596954 0.80507999580893 1.51683808401541 1.28758152776152 1.56992056004343 0.000688654732171229 NA NA NA 0.0133098261043341 21.5511706589477 a38 gain_cnaBRCA30_(CRNKL1,FOXA2) 1020 Lenalidomide TNFA 5 40 1.6094379124341 NA 5.21529028290541 4.13465611363149 1.08063416927392 0.770955983269163 0.609334223541771 1.7258909395209 1.40168076093216 1.7734670522734 0.000730115554124565 NA NA NA 0.0323520278009066 22.2473894768641 a39 loss_cnaBRCA18 306 TG101348 JAK2 15 33 2.32630161961136 NA 2.34747113011378 3.62371520508592 -1.27624407497214 0.886301930602439 1.23865157306843 1.11660159870129 1.43996535594213 1.03034953712656 0.000810060665649216 NA NA NA 0.000244160398903547 23.7039345537902 a40 loss_cnaBRCA33 1011 ABT-263 BCL2, BCL2L1, BCL2L2 5 38 0.693147180559945 NA -0.547531362441633 1.9752994406083 -2.52283080304993 1.52373509498807 1.46165364105179 1.71875336054142 1.65568858481249 1.7260113697213 0.000818859471587883 NA NA NA 0.017238404853607 23.7039345537902 a41 gain_cnaBRCA27_(CLTC,PPM1D) 293 MP470 PDGFR 9 39 2.99573227355399 NA 1.93747993302942 3.89945561603492 -1.9619756830055 2.02817238041571 1.34875588062599 1.31733842738989 0.967361404755626 1.45465588783561 0.000868793042258281 NA NA NA 0.0205296708185256 24.5359869178259 a42 gain_cnaBRCA47_(EGFR) 1010 Gefitinib EGFR 7 38 -0.693147180559945 NA 0.256333873407622 1.610554330176 -1.35422045676838 0.837986116162926 0.935276524422725 1.46828026036567 1.61604163917327 1.44793590067305 0.000894144739929568 NA NA NA 0.00387619183627867 24.6507189134392 a43 ASH1L_mut 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 3 45 2.77258872223978 NA -2.91958470651376 -0.270990034540094 -2.64859467197367 0.736989324806869 1.27696827120557 2.10486816727256 3.59380330599462 2.07412723690712 0.00095646284423339 NA NA NA 0.0121064373221575 25.7555424962289 a44 gain_cnaBRCA30_(CRNKL1,FOXA2) 1495 AZD-2281 PARP1, PARP2 5 40 2.30258509299405 NA 5.49153794191074 3.81208546633589 1.67945247557485 1.06260936976196 0.996629600851984 1.67451203656853 1.58049846290276 1.68513204317747 0.00100423233820312 NA NA NA 0.020721600247841 26.4272869183044 a45 gain_cnaBRCA16 1268 XAV 939 TNKS1 (tankyrase-1) 16 31 1.6094379124341 NA 4.25801689491929 3.35353341652807 0.904483478391224 0.901877826053893 0.805888700915085 1.07791320950857 1.00288914114757 1.12234292075839 0.00105626167194959 NA NA NA 0.00220347441188044 27.1787864433429 a46 gain_cnaBRCA48 299 OSI-027 MTORC1/2 5 43 2.99573227355399 NA 3.8863312381348 0.964625182874123 2.92170605526068 1.51676685763077 1.80313194516842 1.64135221428878 1.92627234736949 1.62035066989387 0.0011293885315503 NA NA NA 0.00887681119779022 28.428673493089 a47 PTEN_mut 156 AZD6482 PI3Kbeta 8 39 1.63315443905142 NA 0.591946878925776 2.35307655538853 -1.76112967646275 1.23160663120333 1.32240135482342 1.3457179549204 1.4299449449554 1.33176638850155 0.00116868098278101 NA NA NA 0.00415066510386929 28.7918236162156 a48 gain_cnaBRCA30_(CRNKL1,FOXA2) 1018 ABT-888 PARP1, PARP2 5 40 1.6094379124341 NA 5.26870718310933 4.29487231813601 0.973834864973327 0.744605956460558 0.574161610982233 1.64474027930356 1.3078526387331 1.69609887938583 0.00120565098943032 NA NA NA 0.0405586115836815 29.0838183471118 a49 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 45 Z-LLNle-CHO g-secretase 3 9 0.940007258491471 NA 3.01082309376699 0.296199837022924 2.71462325674407 0.844123505260049 0.931576360305472 2.96759632951266 3.21590767207433 2.91401045841687 0.00123247748927576 NA NA NA 0.0105720681914683 29.1241976496409 a50 loss_cnaBRCA33 1013 Nilotinib ABL 5 35 0.693147180559945 NA 1.98392243753057 3.37704808881628 -1.3931256512857 1.11808162190338 0.804456648860836 1.65261508254235 1.24599637807667 1.73175975766806 0.001361724299483 NA NA NA 0.047160300289122 30.7673768522019 a51 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 110 Roscovitine CDKs 4 9 2.77258872223978 NA 5.22915776661846 3.56929783321298 1.65985993340548 0.144414151948213 0.756810231253267 2.55441122094017 11.4937484381773 2.19323136086146 0.00136391210817098 NA NA NA 0.000124302209269457 30.7673768522019 a52 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1091 BMS-536924 IGF1R 15 32 1.38629436111989 NA 3.73758338555396 2.68848292246347 1.0491004630905 0.771561686389707 1.06511899112847 1.06699663678858 1.35971041796989 0.984960808913001 0.00138172864350505 NA NA NA 0.000484727044823223 30.7673768522019 a53 gain_cnaBRCA16 1375 Temozolomide DNA akylating agent 16 30 3.40119738166216 NA 6.33022426224401 5.67074016110856 0.659484101135448 0.681580324814596 0.595238419672112 1.05346800508377 0.967580895641084 1.10793268602979 0.00143024858364388 NA NA NA 0.00295580618303857 31.2468836792688 a54 gain_cnaBRCA62 203 BMS-345541 IKBKB 10 39 2.77258872223978 NA 2.66634478694871 3.75438018607554 -1.08803539912683 1.23642364772433 0.816042794128388 1.19345020954079 0.879985918361709 1.33330679096181 0.00152329504076184 NA NA NA 0.0228837405694781 31.4154924585213 a55 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1042 BIRB 0796 p38, JNK2 16 27 2.30258509299405 NA 4.92022915520357 4.03851638388577 0.881712771317807 0.56979578404982 0.93867257805551 1.07118024360379 1.54741891042268 0.93931876985722 0.00153351875086214 NA NA NA 0.000428443621839655 31.4154924585213 a56 PIK3CA_mut 1527 GDC0941 (rescreen) PI3K 16 29 1.38629436111989 NA 0.278195882082358 1.36821995682914 -1.09002407474678 0.929986577154591 1.08868830948079 1.05205355963237 1.1720858144876 1.00122694921435 0.00155925822197447 NA NA NA 0.00114841684544385 31.4154924585213 a57 gain_cnaBRCA30_(CRNKL1,FOXA2) 194 AUY922 HSP90 5 42 -1.36257783450257 NA -0.180734368309906 -2.65720096844421 2.4764666001343 2.01992827531153 1.50340977995389 1.59127326761978 1.22601709694487 1.64723326477911 0.00157982887527522 NA NA NA 0.0497192914290933 31.4154924585213 a58 gain_cnaBRCA62 224 AS605240 PI3Kgamma 10 39 2.99573227355399 2.32630161961136 1.91764925446349 3.61707918390344 -1.69942992943995 2.457573542675 1.04929992741749 1.18788204599994 0.69150725295902 1.61958452968022 0.00159458693339542 NA NA NA 0.0586866489398134 31.4154924585213 a59 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 153 Midostaurin KIT 7 40 -0.669430653942629 NA 2.14617874393337 0.34373499565791 1.80244374827546 0.465456719411063 1.39750673749798 1.3737482336889 3.87241965387473 1.28975675029836 0.00162881688296247 NA NA NA 5.77866369865665e-07 31.4154924585213 a60 BRCA2_mut 1259 BMN-673 PARP1 5 41 2.30258509299405 NA 1.32202342747221 3.54743006647518 -2.22540663900297 2.34346153865924 1.26809724666549 1.58911489854823 0.949623709325391 1.75491796457626 0.00164384849986623 NA NA NA 0.100539374732094 31.4154924585213 a61 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 228 KIN001-102 AKT1 15 34 2.32630161961136 NA 1.02985257637361 2.34687316345357 -1.31702058707995 1.12769218212556 1.33188900780725 1.03337049318143 1.16789014587077 0.988836591757915 0.00167738814159206 NA NA NA 0.00120593595619338 31.4154924585213 a62 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 283 GSK2126458 PI3K, MTOR 14 34 -2.05572501506252 0.0237165266173161 -4.16430319427971 -2.59873337271835 -1.56556982156136 1.19115362941844 1.57581470939246 1.05975477061366 1.31433073190207 0.993498672293106 0.0016821491773282 NA NA NA 0.000706011923296896 31.4154924585213 a63 CDH1_mut 290 KIN001-260 IKK 4 45 2.99573227355399 NA 3.5437987158241 5.17743140560602 -1.63363268978192 2.39548530236987 0.750225661998239 1.72855184246125 0.681963144656222 2.17752174116613 0.00178172349315438 NA NA NA 0.266120676792502 32.5870687849949 a64 gain_cnaBRCA30_(CRNKL1,FOXA2) 1133 JNJ-26854165 MDM2 4 39 2.30258509299405 NA 4.20827124684928 2.841692143309 1.36657910354028 0.828040599564663 0.776310833729169 1.75154787743868 1.65037693110549 1.76035042171914 0.00181277879533537 NA NA NA 0.0400895365186706 32.5870687849949 a65 PTEN_mut 1230 IOX2 EGLN1 8 39 -2.30258509299405 NA -0.380827835579582 0.378753081106998 -0.75958091668658 1.00386246803949 0.477155367325216 1.2857267828253 0.756658348000613 1.59189431514635 0.00182931122810663 NA NA NA 0.0713078072663369 32.5870687849949 a66 gain_cnaBRCA31 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 14 32 0 NA 2.02167084252515 0.0545157779385651 1.96715506458658 1.28747317335946 2.05085911879506 1.05860884438579 1.52791926487571 0.959185858530521 0.00190230013908804 NA NA NA 0.000340050004749582 33.0812483906197 a67 gain_cnaBRCA30_(CRNKL1,FOXA2) 133 Doxorubicin DNA intercalating 5 43 0.0237165266173161 NA 1.28311630929959 -1.29968699432854 2.58280330362813 0.823053333616639 1.72298395311512 1.55201468309013 3.13807525969045 1.49902922714891 0.00195694650156247 NA NA NA 0.00030314143612574 33.0812483906197 a68 TP53_mut 1166 QL-VIII-58 MTOR, ATR 23 3 2.30258509299405 NA -1.7475220532706 0.232767771360383 -1.98028982463098 0.937982554268656 0.816079944295103 2.13293196361327 2.1112224482416 2.42658803034485 0.00196134918154862 NA NA NA 0.0355458574249573 33.0812483906197 a69 gain_cnaBRCA30_(CRNKL1,FOXA2) 1028 VX-702 p38 5 40 0.693147180559945 NA 4.28272603092064 3.31984460691537 0.962881424005274 0.726040125598222 0.603479847801713 1.56334637495703 1.32620965433819 1.595548596217 0.00197223560906347 NA NA NA 0.0385089919570864 33.0812483906197 a70 gain_cnaBRCA48 283 GSK2126458 PI3K, MTOR 5 43 -2.05572501506252 0.0237165266173161 -1.00082976547479 -3.29425652476665 2.29342675929186 2.02117554768388 1.42089871821764 1.54671230477772 1.13469943861133 1.61406772339742 0.00202089810013456 NA NA NA 0.0625523333554045 33.0812483906197 a71 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 7 38 -0.669430653942629 NA -0.985570879861861 -3.94683212897516 2.96126124911329 2.4936539331086 2.1379771108254 1.35151050625991 1.1875189294698 1.38507621719582 0.00202847278325762 NA NA NA 0.0192304553278841 33.0812483906197 a72 gain_cnaBRCA30_(CRNKL1,FOXA2) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 5 42 -2.30258509299405 NA 1.15449850787385 -0.294784900904003 1.44928340877786 0.685923167153267 0.961381270109621 1.5415122531848 2.11289467710021 1.50750119004565 0.00213580220658877 NA NA NA 0.00524636179768193 34.3478524306825 a73 gain_cnaBRCA30_(CRNKL1,FOXA2) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 4 39 -1.38629436111989 0.693147180559945 -0.894866552311383 -2.35647469869196 1.46160814638057 0.82010773107943 0.859325359838063 1.70645616302482 1.78221481275002 1.70087863653414 0.0023066831873163 NA NA NA 0.0312200717394672 36.5877871588157 a74 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 11 Paclitaxel Microtubules 3 9 -2.27886856637673 NA -0.795631249992704 -3.86039522964307 3.06476397965036 1.01163933450522 1.17259842619121 2.68315822231799 3.02950258567132 2.6136517934833 0.00241992118380606 NA NA NA 0.0121053849047699 37.865226199041 a75 gain_cnaBRCA30_(CRNKL1,FOXA2) 1262 UNC1215 LMBL3 5 41 0 NA 3.48795592603372 2.66844279567646 0.819513130357255 0.696506973756265 0.520533417477448 1.5206844229469 1.17660434315197 1.57437179408901 0.00247835225810287 NA NA NA 0.0561296754385771 38.2624543954308 a76 gain_cnaBRCA30_(CRNKL1,FOXA2) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 4 42 1.63315443905142 NA 4.14821435431644 1.72596455663266 2.42224979768378 1.33814232259779 1.4526440437425 1.6761520555233 1.81015857340299 1.66747649440894 0.00252758710587851 NA NA NA 0.0298284239065412 38.5091198670622 a77 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 106 XMD8-85 MAP2K5 (ERK5) 4 9 2.07944154167984 NA 4.54415039899455 2.63734650644533 1.90680389254923 0.229870323463856 0.950342462595019 2.32736523710508 8.29512859170376 2.00643869720656 0.00259461383428156 NA NA NA 0.000227069733651202 39.0169267365535 a78 gain_cnaBRCA62 1164 XMD8-92 MAP2K5 (ERK5) 4 22 2.30258509299405 NA 5.56160828412881 3.57955820540439 1.98205007872442 0.832419127951691 1.1237003821851 1.81581357038915 2.38107224133784 1.76385993112347 0.00272730782833308 NA NA NA 0.00826064706858979 39.8999694518686 a79 gain_cnaBRCA63 1164 XMD8-92 MAP2K5 (ERK5) 4 22 2.30258509299405 NA 5.56160828412881 3.57955820540439 1.98205007872442 0.832419127951691 1.1237003821851 1.81581357038915 2.38107224133784 1.76385993112347 0.00272730782833308 NA NA NA 0.00826064706858979 39.8999694518686 a80 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 190 Bleomycin DNA damage 7 41 4.15888308335967 NA 4.84729314895933 1.60566115758773 3.24163199137161 1.73521129810126 2.60105136219894 1.29398996870911 1.86814827388383 1.24627757778344 0.00275671263161714 NA NA NA 0.00141353034255011 39.8999694518686 a81 gain_cnaBRCA30_(CRNKL1,FOXA2) 1017 Olaparib PARP1, PARP2 5 40 1.6094379124341 NA 5.15349450646009 3.9391735467375 1.21432095972258 0.825181260922816 0.805330406981379 1.50436642974858 1.47158087226143 1.50785435294095 0.00279667734542054 NA NA NA 0.0265196169688275 39.9786752871907 a82 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 172 Embelin XIAP 7 41 3.46573590279973 NA 3.96662051148194 2.8268449036552 1.13977560782674 1.16433438963698 0.834269940373699 1.28884916254152 0.978907449587663 1.36619522371404 0.00285590392394155 NA NA NA 0.0415824873281204 40.3274530918527 a83 gain_cnaBRCA30_(CRNKL1,FOXA2) 1199 Tamoxifen ER 5 42 1.6094379124341 NA 5.02721676897249 3.73130753816487 1.29590923080763 0.699145546117374 0.884228905113937 1.49062324647415 1.85356144797648 1.46558116717598 0.00289310809862122 NA NA NA 0.0100598640744049 40.36060081197 a84 gain_cnaBRCA48 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 5 42 2.32630161961136 NA 3.26936478995435 1.19640907204458 2.07295571790977 1.2369177407106 1.41453886525432 1.48103876702368 1.67590426564573 1.46546395353872 0.00306155015272297 NA NA NA 0.0158140916200808 41.6194496151008 a85 loss_cnaBRCA33 333 T0901317 LXR 6 42 2.32630161961136 NA 3.90159198267408 4.85455680936622 -0.952964826692143 0.212445670390636 0.73749066455299 1.36182375333557 4.48568721094609 1.29217205382492 0.00311689007779283 NA NA NA 3.64928414986175e-07 41.6194496151008 a86 gain_cnaBRCA63 1495 AZD-2281 PARP1, PARP2 5 40 2.30258509299405 NA 5.35593369987332 3.82903599659057 1.52689770328275 1.09906115577872 1.02026062926237 1.48553188782642 1.38927455970446 1.49657612916679 0.00312238251601983 NA NA NA 0.0326018382377793 41.6194496151008 a87 ASH1L_mut 136 Mitomycin C DNA crosslinker 3 45 2.77258872223978 NA -2.49443318567985 0.0230365742806846 -2.51746975996053 0.56881178594527 1.37864361050635 1.8599063626589 4.42583965762404 1.82604825552843 0.00312711988644423 NA NA NA 0.00331003647342206 41.6194496151008 a88 BRCA2_mut 167 OSU-03012 PDPK1 (PDK1) 6 42 2.77258872223978 NA 0.96013711272596 2.43195644399264 -1.47181933126668 1.27043465321327 1.05958398106323 1.35715326167548 1.158516360951 1.38905396605733 0.00321144406385045 NA NA NA 0.0350623887787251 42.256035017414 a89 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 7 41 2.07944154167984 NA 4.36571300383425 3.01772133200832 1.34799167182594 1.08095163315334 1.06161506960852 1.26672236708618 1.24704161637056 1.26975559260196 0.00332250018497565 NA NA NA 0.0154058351688223 43.2261007211607 a90 gain_cnaBRCA30_(CRNKL1,FOXA2) 1161 ZG-10 IRAK1 3 23 2.30258509299405 NA 4.06401935541007 1.70298336746151 2.36103598794856 1.48403456903376 1.15511855705162 1.9907263223089 1.59095754048762 2.04397719483876 0.00346018090508779 NA NA NA 0.100393242273863 44.4605643395185 a91 loss_cnaBRCA57 304 SB52334 ALK5 5 44 2.99573227355399 NA 5.82529795685443 4.12877740588506 1.69652055096937 0.44607406880755 1.21643102642085 1.44906158126248 3.80322612229966 1.39467056834378 0.00354645307370542 NA NA NA 3.16726670365855e-05 44.4605643395185 a92 loss_cnaBRCA36_(FAT1,IRF2) 155 AP-24534 ABL 9 38 -0.669430653942629 NA 0.487487303257039 1.67222429035905 -1.18473698710201 1.10454546938428 1.02498993017367 1.13963239749318 1.07260137309008 1.15585231837475 0.0035806356234821 NA NA NA 0.0130646280393769 44.4605643395185 a93 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 158 PF-562271 FAK 7 38 0.940007258491471 NA 3.59114146590815 2.10153339443581 1.48960807147234 0.867207076788707 1.21886905154431 1.26653439974036 1.71770746727344 1.22212313913869 0.00360798322563753 NA NA NA 0.00254475987929587 44.4605643395185 a94 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 140 Vinorelbine Microtubules 7 40 -2.74887219562247 NA -1.98966565256111 -3.88159362178315 1.89192796922204 1.84522992954102 1.45093492613062 1.25337217472366 1.02530743672288 1.30393716158413 0.00373156937985047 NA NA NA 0.0351324208148771 44.4605643395185 a95 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 207 AS601245 JNK 7 41 2.07944154167984 NA 3.52242428387577 2.05172351814862 1.47070076572715 1.49861261105069 1.12383665890435 1.24689212653105 0.981374876257067 1.30864281216895 0.00380072487147013 NA NA NA 0.0412940840601722 44.4605643395185 a96 loss_cnaBRCA57 179 5-Fluorouracil DNA antimetabolite 5 44 3.46573590279973 NA 5.96434714638697 3.8229686814252 2.14137846496176 0.5620946704333 1.54816719935833 1.4372877422625 3.80964022183496 1.38317002572416 0.00380079377190529 NA NA NA 3.03556327445545e-05 44.4605643395185 a97 loss_cnaBRCA33 253 XMD14-99 EPHB3, CAMK1 6 42 2.32630161961136 NA 4.10627959636739 5.05121930363091 -0.944939707263524 1.10277601738243 0.646640443837679 1.32987272662341 0.856873646478507 1.4613062270827 0.00381988698962028 NA NA NA 0.0905998806865004 44.4605643395185 a98 gain_cnaBRCA19 344 THZ-2-49 CDK9 4 45 2.99573227355399 NA -0.19164715449597 1.96100140869714 -2.15264856319311 0.384684815191105 1.39925447855592 1.58592581258153 5.59587609956404 1.53842535163062 0.00386292976702669 NA NA NA 4.01086027199848e-06 44.4605643395185 a99 loss_cnaBRCA33 1248 FK866 NAMPT 4 40 0 NA -4.25589713403398 -0.290186743999323 -3.96571039003465 1.72790788179117 2.5235219488001 1.60218547003221 2.29509364001729 1.57149827522614 0.00389722707881235 NA NA NA 0.0115079440006155 44.4605643395185 a100 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 15 30 0.693147180559945 NA 1.46935046029271 0.203678153387201 1.26567230690551 1.37495891884933 1.28107575023077 0.964409988993388 0.92051645293135 0.987976165092126 0.00391200007335227 NA NA NA 0.00616338335053191 44.4605643395185 a101 gain_cnaBRCA27_(CLTC,PPM1D) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 10 36 0 NA 2.25938063734321 0.207058064332057 2.05232257301116 0.935835756005775 2.06174031813304 1.08766228018548 2.19303714336652 0.995432138063629 0.00394484726839389 NA NA NA 7.08601356706945e-05 44.4605643395185 a102 gain_cnaBRCA30_(CRNKL1,FOXA2) 165 DMOG Prolyl-4-Hydroxylase 5 41 8.29404964010203 NA 9.37657948895342 7.34966363750595 2.02691585144748 1.09143723744497 1.43405719831364 1.44124624124491 1.8571071078649 1.41341353317775 0.00394713300605419 NA NA NA 0.00973173676672607 44.4605643395185 a103 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 15 28 1.6094379124341 NA 3.49593202971136 2.06988213052665 1.42604989918471 1.1294347285387 1.60421575400763 0.977038109244388 1.26262267588475 0.888938969476002 0.00396175004701741 NA NA NA 0.0016493750486111 44.4605643395185 a104 loss_cnaBRCA22_(SYNCRIP,ZNF292) 286 KIN001-236 TIE2 19 30 2.32630161961136 NA 4.92427229873228 4.29679739602097 0.62747490271131 0.670178945133732 0.72870113223526 0.887691966639205 0.936279641829243 0.861086767885974 0.00399334889999993 NA NA NA 0.00363347151195337 44.4605643395185 a105 loss_cnaBRCA18 163 JQ1 BRD4 15 32 0.940007258491471 NA -0.5429216097774 0.718497223191348 -1.26141883296875 1.22451567182847 1.39049704603165 0.940612123958698 1.03013694474418 0.907171170603146 0.00431878292012943 NA NA NA 0.00360978285633684 47.1080037389277 a106 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 5 43 2.32630161961136 NA 4.14427869517329 5.05316618351252 -0.908887488339227 0.836795385665982 0.619372914640404 1.41745113163439 1.08615260541365 1.46743176341011 0.00434956004635098 NA NA NA 0.0705844416636019 47.1080037389277 a107 loss_cnaBRCA23 1149 TW 37 BCL2, BCL2L1 3 40 1.6094379124341 NA 1.76802978551511 -0.285665294394646 2.05369507990975 2.2455713827047 1.04994750759701 1.80496610374963 0.91455346097088 1.95599786184549 0.00439281378919355 NA NA NA 0.252835079395661 47.1080037389277 a108 gain_cnaBRCA31 208 SB-715992 KIF11 16 33 -2.05572501506252 NA -0.272041410368004 -1.70916370693627 1.43712229656826 1.51644640348655 1.60481656962734 0.911213922561604 0.947690794256948 0.895505644549755 0.00441503387643051 NA NA NA 0.00460357536192166 47.1080037389277 a109 gain_cnaBRCA31 1502 Bicalutamide ANDR (androgen receptor) 14 31 2.30258509299405 NA 4.91463204563023 4.39738039818966 0.51725164744057 0.628875698999993 0.48844489450932 0.967180070975586 0.822502202363801 1.05897646439766 0.00443455601307809 NA NA NA 0.0128065668297041 47.1080037389277 a110 gain_cnaBRCA30_(CRNKL1,FOXA2) 1021 Axitinib PDGFR, KIT, VEGFR 5 40 0.693147180559945 NA 3.81607769979245 2.29313613072667 1.52294156906578 0.97856356047035 1.08276845017088 1.41866703752885 1.55630316781239 1.40652562311492 0.0045910189074813 NA NA NA 0.0210565515221422 47.124136757402 a111 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 59 WZ-1-84 BMX 3 9 2.32630161961136 NA 2.07446264820024 4.05770849161557 -1.98324584341533 1.12856024848025 0.722380609612597 2.41895830792028 1.75732385230299 2.74543061791057 0.00462452847824715 NA NA NA 0.0777326693478932 47.124136757402 a112 gain_cnaBRCA27_(CLTC,PPM1D) 59 WZ-1-84 BMX 3 9 2.32630161961136 NA 2.07446264820024 4.05770849161557 -1.98324584341533 1.12856024848025 0.722380609612597 2.41895830792028 1.75732385230299 2.74543061791057 0.00462452847824715 NA NA NA 0.0777326693478932 47.124136757402 a113 loss_cnaBRCA24 175 PAC-1 CASP3 agonist 3 45 0.940007258491471 NA 0.52462784855409 2.52649873067704 -2.00187088212295 0.706766199409347 1.14357046628641 1.77454871335589 2.83243721020606 1.75054440556143 0.00464302227972926 NA NA NA 0.0241486620383819 47.124136757402 a114 gain_cnaBRCA30_(CRNKL1,FOXA2) 1043 JNK Inhibitor VIII JNK 4 39 2.30258509299405 NA 5.76790424948945 4.69778522545205 1.0701190240374 0.987559023750375 0.651422216115436 1.5698688888397 1.0836000667317 1.64274259852348 0.00469943399909357 NA NA NA 0.116555992549233 47.124136757402 a115 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 282 EKB-569 EGFR 13 34 0.916290731874155 2.99573227355399 0.21059914828701 2.1009229799742 -1.89032383168719 1.94585153121745 1.9505476694714 0.969746705378754 0.971463547634839 0.969124652154476 0.00471330968552721 NA NA NA 0.00699322100884533 47.124136757402 a116 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 235 QL-XII-47 BTK, BMX 15 34 2.32630161961136 NA 0.821212489759343 2.09933800881825 -1.2781255190589 1.32422291548285 1.41818869715521 0.918944288863524 0.965189096273011 0.901237981675313 0.00474708062647658 NA NA NA 0.00493850418371568 47.124136757402 a117 gain_cnaBRCA58_(CCND1) 153 Midostaurin KIT 9 38 -0.669430653942629 NA 1.80601083060395 0.329435619958273 1.47657521064568 0.758938759403716 1.43648945542791 1.10086318473802 1.94557886568581 1.02790535988016 0.00476818594923248 NA NA NA 0.00025752214698433 47.124136757402 a118 gain_cnaBRCA62 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 9 37 1.63315443905142 NA 3.2372419872742 1.62022137595594 1.61702061131827 1.63277319454385 1.42459811825486 1.1040316540271 0.990352252671578 1.13507142161547 0.00480235610793111 NA NA NA 0.0193926624860534 47.124136757402 a119 gain_cnaBRCA64_(SDHC) 229 LY317615 PRKCB (PKCbeta) 8 41 2.99573227355399 2.32630161961136 1.93426099470991 3.63649957489261 -1.7022385801827 1.05732371383104 1.55740503679861 1.13970781056804 1.60995025261935 1.09299670924515 0.00495821875207926 NA NA NA 0.00194470182610877 47.6594429000114 a120 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 94 TGX221 PI3Kbeta 5 9 2.30258509299405 NA 4.91912272985034 3.13030493514629 1.78881779470405 0.306298048133475 1.12577720085468 1.91102865615095 5.84012142945338 1.58896253481239 0.00502100035510653 NA NA NA 0.00120618972586139 47.6594429000114 a121 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 229 LY317615 PRKCB (PKCbeta) 15 34 2.99573227355399 2.32630161961136 2.41454930735577 3.77506855641 -1.36051924905422 1.29454014764312 1.57167079191055 0.910347852109137 1.05096721143119 0.865651544876236 0.00511963323920521 NA NA NA 0.00333972672012047 47.6594429000114 a122 gain_cnaBRCA63 1219 PFI-1 BRD2, BRD3, BRD4 6 41 2.30258509299405 NA 4.20599994220763 3.02123439710469 1.18476554510295 1.28430839473324 0.864825238509856 1.28650324791145 0.922493032017464 1.36994792976251 0.00512056856681044 NA NA NA 0.0737671553046275 47.6594429000114 a123 gain_cnaBRCA16 1003 Camptothecin TOP1 15 30 -2.30258509299405 NA -1.62107047715371 -2.98338692746724 1.36231645031353 1.34128956402668 1.51453394766601 0.932846247722884 1.01567661961353 0.899495486656438 0.00512563929429558 NA NA NA 0.00434693859562301 47.6594429000114 a124 gain_cnaBRCA14_(RAD21) 1268 XAV 939 TNKS1 (tankyrase-1) 21 26 1.6094379124341 NA 4.07523739232121 3.32722388432051 0.748013508000701 0.906491755089364 0.833867273036155 0.862863909081032 0.825174088789104 0.897041450346341 0.00515250640036363 NA NA NA 0.00573366569502378 47.6594429000114 a125 gain_cnaBRCA15 64 CMK RSK 6 6 1.38629436111989 NA 1.35346657565916 3.05484637620688 -1.70137980054772 0.962552326087608 0.665092646361578 2.05654167048103 1.76757123164738 2.5581094752065 0.00516373187168905 NA NA NA 0.00622322134434838 47.6594429000114 a126 gain_cnaBRCA30_(CRNKL1,FOXA2) 1013 Nilotinib ABL 4 36 0.693147180559945 NA 4.4281140991652 3.0667733027656 1.36134079639959 0.673927595850159 0.885765339161185 1.56311253650356 2.02001046519287 1.53690908439562 0.00519465203062961 NA NA NA 0.0187165412606099 47.6594429000114 a127 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 63 BMS-509744 ITK 3 9 2.32630161961136 NA 4.92040275903653 3.15475288396592 1.76564987507061 0.0719211827531552 0.832233878016359 2.36978611505545 24.5497891925748 2.1215789475899 0.0052273505901213 NA NA NA 0.00019588353220939 47.6594429000114 a128 gain_cnaBRCA30_(CRNKL1,FOXA2) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 5 43 2.07944154167984 NA 4.54529265959644 3.0595372637488 1.48575539584764 1.16982571693236 1.06452362957306 1.38326869394279 1.27006559553481 1.3956997802327 0.00529589310497833 NA NA NA 0.0439636790219286 47.9071455176126 a129 gain_cnaBRCA31 1378 Bleomycin (50 uM) DNA damage 15 33 3.91202300542815 NA 4.90504278870258 3.31620616974704 1.58883661895554 1.63545830263344 1.79091357771935 0.910472763206598 0.971493199427446 0.88716543261616 0.00534979503817878 NA NA NA 0.00507886345397811 47.9495601462172 a130 gain_cnaBRCA48 1261 rTRAIL TR10A (DR4), TR10B (DR5) 5 42 -2.30258509299405 NA -1.32525250528142 0.000423553043053024 -1.32567605832448 1.03335802886408 0.950450934973872 1.38363514346263 1.28288165504625 1.39478642141682 0.00538340341912794 NA NA NA 0.0425000944550223 47.9495601462172 a131 PTEN_mut 238 CAL-101 PI3Kdelta 9 40 2.99573227355399 2.32630161961136 3.94935499873397 4.89212629408908 -0.942771295355116 0.988520403863759 0.851731980025654 1.07557963390554 0.953719611320286 1.10688728081658 0.00542778057021656 NA NA NA 0.0229096527581038 47.975779559189 a132 gain_cnaBRCA63 186 Bexarotene Retinioic acid X family agonist 6 41 2.07944154167984 NA 4.77449951019237 3.43317218691732 1.34132732327505 1.00157679081515 1.06034485854623 1.27263445590622 1.33921566032235 1.26499158501514 0.00557748733080366 NA NA NA 0.0196819332499667 48.4132829731133 a133 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1026 17-AAG HSP90 16 27 0 NA 0.0535081450809483 -1.45900060300025 1.5125087480812 1.59240083174524 1.66478948379515 0.923006127783963 0.949829162311801 0.908528533369394 0.00558184443413823 NA NA NA 0.00568008140479424 48.4132829731133 a134 gain_cnaBRCA30_(CRNKL1,FOXA2) 1175 AG-014699 PARP1, PARP2 4 39 1.6094379124341 NA 5.17273525164157 3.72709222772338 1.44564302391819 0.63087941502056 0.961909679540324 1.53523593686378 2.29147280684548 1.50288852962685 0.00560271173538059 NA NA NA 0.0110508121282634 48.4132829731133 a135 loss_cnaBRCA28_(GPS2) 157 JNK-9L JNK 4 43 1.63315443905142 NA 1.41305007465676 -0.0704074023442878 1.48345747700105 1.17367898089262 0.960561160445966 1.51959721250881 1.26393801128895 1.54436545853293 0.00564597288216189 NA NA NA 0.0817900705080456 48.4257185204093 a136 loss_cnaBRCA42 206 Ruxolitinib JAK1, JAK2, TYK2 3 46 1.65632149833295 0.0237165266173161 3.38744705164971 4.43435697846229 -1.04690992681258 1.44000738695215 0.540210466398809 1.72660501365303 0.727017053036385 1.93796675912551 0.00569538536401039 NA NA NA 0.334744565658201 48.4903434778502 a137 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1016 Temsirolimus MTOR 5 39 -1.6094379124341 NA -0.065554790899635 -1.96701610888653 1.90146131798689 1.65691847862738 1.34630373070724 1.37896574036251 1.14758893845043 1.41235686614937 0.00586679702568491 NA NA NA 0.0600762996931043 49.5213887880219 a138 gain_cnaBRCA27_(CLTC,PPM1D) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 10 33 1.6094379124341 NA 3.75157961266015 2.20848133253986 1.54309828012029 1.02637402939147 1.57571151177084 1.04774284776839 1.5034463421051 0.979302536405348 0.00593278305237341 NA NA NA 0.00138941817663714 49.5213887880219 a139 PIK3CA_mut 235 QL-XII-47 BTK, BMX 17 32 2.32630161961136 NA 0.919075000890581 2.12723139472096 -1.20815639383038 1.69919317016682 1.21181262500741 0.864851833950602 0.711017684770805 0.996982841157465 0.00594479060500479 NA NA NA 0.0154170928171048 49.5213887880219 a140 gain_cnaBRCA30_(CRNKL1,FOXA2) 1194 SB-505124 TGFR1 (ALK5) 5 42 2.30258509299405 NA 5.42516498263606 4.26564600669849 1.15951897593756 0.867693975614458 0.848237270388441 1.36416438141663 1.3363224921741 1.36697480341388 0.00601179913244169 NA NA NA 0.0369853871736424 49.7218729675302 a141 gain_cnaBRCA30_(CRNKL1,FOXA2) 1502 Bicalutamide ANDR (androgen receptor) 4 41 2.30258509299405 NA 5.29990663391786 4.48595157187881 0.813955062039045 1.04073050970761 0.479977322251184 1.51181069658378 0.782099740948045 1.69581983211507 0.0060773433009694 NA NA NA 0.215725764623774 49.8710088350976 a142 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 15 28 1.6094379124341 NA 3.65815776844924 2.44463816218003 1.21351960626921 1.1997167730592 1.36639287445039 0.925035873703158 1.01150507646468 0.888119097340381 0.00611597137454345 NA NA NA 0.00506036467210604 49.8710088350976 a143 ASH1L_mut 177 GSK-650394 SGK3 3 44 2.77258872223978 NA 1.49562143201301 4.18617635981678 -2.69055492780377 0.646737615513489 1.60141762879731 1.71225420128911 4.1601955155609 1.68010822375199 0.0062415000544529 NA NA NA 0.00379654816251099 50.5386916996574 a144 gain_cnaBRCA16 1030 KU-55933 ATM 14 28 2.30258509299405 NA 4.7532904780626 3.95680379354053 0.796486684522063 0.65805824899612 0.924371301994924 0.940302272147202 1.21035893970954 0.861652328239888 0.00648339623165265 NA NA NA 0.00282166126954827 51.3229304732427 a145 loss_cnaBRCA33 179 5-Fluorouracil DNA antimetabolite 6 43 3.46573590279973 NA 2.40106622500968 4.27037117126943 -1.86930494625975 1.50344716809619 1.50566208702858 1.24171110769761 1.2433459491808 1.24151691296738 0.00648435954857004 NA NA NA 0.0267211901211821 51.3229304732427 a146 MLL3_mut 230 GSK429286A ROCK2 3 46 2.99573227355399 2.32630161961136 4.07597889634173 5.49221171795073 -1.41623282160899 0.856896783064514 0.833539418511638 1.69700854233588 1.65274610618111 1.69905920482778 0.00650791580762942 NA NA NA 0.0953432441202525 51.3229304732427 a147 gain_cnaBRCA14_(RAD21) 94 TGX221 PI3Kbeta 6 8 2.30258509299405 NA 2.80065463698461 4.49555378045758 -1.69489914347297 1.25197561957453 0.666884867619615 1.77427212774249 1.35377967188289 2.54151687310399 0.00651564969303625 NA NA NA 0.0192248643563955 51.3229304732427 a148 ASH1L_mut 201 Epothilone B Microtubules 3 45 -3.44201937618241 NA -6.90274720680732 -4.05795863930412 -2.8447885675032 0.342061507876007 1.71278311068778 1.69670712446026 8.31659950623383 1.66091582159568 0.00660078771854567 NA NA NA 9.2647161060461e-07 51.5313046887673 a149 ASH1L_mut 190 Bleomycin DNA damage 3 45 4.15888308335967 NA -1.97426910524051 2.34857704043408 -4.32284614567459 2.2401093618523 2.56249727471259 1.69568044360525 1.92974781467818 1.68696614366524 0.00663111183921438 NA NA NA 0.0681821785145835 51.5313046887673 a150 gain_cnaBRCA30_(CRNKL1,FOXA2) 1241 CHIR-99021 GSK3B 5 41 2.30258509299405 NA 5.3196132331735 4.09878878264712 1.22082445052638 0.372478027981589 0.942455204685121 1.34810348261205 3.27757440389673 1.29536602318862 0.00670091378938294 NA NA NA 0.000139854327213057 51.7265871781767 a151 gain_cnaBRCA31 256 JW-7-24-1 LCK 16 32 2.32630161961136 NA 2.46348385795605 1.52461176398149 0.938872093974568 1.10602034265042 1.07016774977905 0.867727662532088 0.848874164217176 0.877313013934882 0.00680538792318014 NA NA NA 0.00891253122592248 52.0435950591586 a152 loss_cnaBRCA29_(MAP2K4) 1058 GDC0941 PI3K (class 1) 5 38 1.38629436111989 0.693147180559945 2.87615106519453 1.14466724117056 1.73148382402397 0.817277818502407 1.31776120876076 1.35526953533638 2.11859882260939 1.3139587146083 0.00683187360652224 NA NA NA 0.00447759924076884 52.0435950591586 a153 gain_cnaBRCA31 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 14 32 1.38629436111989 NA 3.72602214899444 2.47911609802039 1.24690605097405 0.862440078081194 1.5374248391825 0.908174368866077 1.4457886207564 0.811035453048272 0.00691157281595125 NA NA NA 0.00113897774284687 52.253315992554 a154 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 60 BI-2536 PLK1, PLK2, PLK3 3 9 -1.36257783450257 NA 0.385102350836358 -2.12550870579716 2.51061105663352 0.941150528822227 1.15212725950309 2.25544065097431 2.66759777500773 2.17910915302562 0.00696547790714968 NA NA NA 0.0176348129485377 52.253315992554 a155 gain_cnaBRCA63 1268 XAV 939 TNKS1 (tankyrase-1) 6 41 1.6094379124341 NA 4.60149503224218 3.52387404969818 1.077620982544 1.05063913723917 0.847357401200754 1.23539748879492 1.02568136322785 1.27174316412053 0.00699910577384018 NA NA NA 0.0533077271450493 52.253315992554 a156 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 8 35 0.693147180559945 NA 0.287838158248652 2.00060047614051 -1.71276231789186 2.14027399789096 1.38575093570741 1.11149652434365 0.800253761705104 1.23598135405012 0.00705933452826678 NA NA NA 0.0610128016621416 52.253315992554 a157 loss_cnaBRCA29_(MAP2K4) 1053 MK-2206 AKT1, AKT2 4 38 1.38629436111989 0.693147180559945 3.43279970537019 1.17925582626324 2.25354387910695 1.00346330011185 1.54838330131941 1.48814450907169 2.24576611706253 1.45541732282094 0.00722677848306136 NA NA NA 0.0116762647098137 52.253315992554 a158 gain_cnaBRCA30_(CRNKL1,FOXA2) 1192 GSK269962A ROCK1, ROCK2 5 41 1.6094379124341 NA 4.28205742721188 2.47110049309924 1.81095693411264 1.28664796987567 1.36496164281212 1.33351875199999 1.40749993511251 1.32674565886092 0.00726761040640087 NA NA NA 0.0306166885772294 52.253315992554 a159 gain_cnaBRCA31 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 13 30 1.6094379124341 NA 3.53542986183992 2.14783639654993 1.38759346528999 1.17195817071665 1.58942394199643 0.93789104593223 1.18399572609445 0.873016587095747 0.00727884969539485 NA NA NA 0.0033178191328667 52.253315992554 a160 ASH1L_mut 155 AP-24534 ABL 3 44 -0.669430653942629 NA -0.210956870298508 1.55829044031484 -1.76924731061334 1.24121839389048 1.04518187675061 1.67753854932934 1.42541177227305 1.6927650105394 0.00728231293650886 NA NA NA 0.126084523197156 52.253315992554 a161 gain_cnaBRCA31 1022 AZD7762 CHEK1, CHEK2 14 31 0.693147180559945 NA 1.84408294662993 0.480536116129349 1.36354683050058 1.35116485817769 1.56427701075439 0.907193933098808 1.00916392418582 0.871678622856567 0.00728602571024243 NA NA NA 0.00578769691268702 52.253315992554 a162 POLR2B_mut 1028 VX-702 p38 3 42 0.693147180559945 NA 2.43195067397277 3.49789434307856 -1.06594366910579 0.369333687691146 0.643508219433027 1.6829102600371 2.8861262988747 1.65645696032439 0.00731068070713684 NA NA NA 0.0207750219906828 52.253315992554 a163 gain_cnaBRCA16 1495 AZD-2281 PARP1, PARP2 16 29 2.30258509299405 NA 4.58945855257782 3.67275074212911 0.916707810448706 1.15726129991633 0.98263767640396 0.875668403511111 0.792135544941304 0.932905212634906 0.00739146140663272 NA NA NA 0.012386371787287 52.506583820491 a164 gain_cnaBRCA30_(CRNKL1,FOXA2) 1219 PFI-1 BRD2, BRD3, BRD4 5 42 2.30258509299405 NA 4.27168635736675 3.04162328923105 1.2300630681357 1.57849979719067 0.837882169336375 1.32554561503454 0.779260833815055 1.46806211320852 0.00746494298870934 NA NA NA 0.157106361817949 52.7052285769911 a165 ASH1L_mut 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 3 43 1.63315443905142 NA -0.375310240810441 2.09789068647137 -2.47320092728181 1.67050828792673 1.46858210045906 1.67293660274115 1.48050802570475 1.68407399661804 0.00753163987429843 NA NA NA 0.117381670130209 52.8538533966676 a166 MLL3_mut 238 CAL-101 PI3Kdelta 3 46 2.99573227355399 2.32630161961136 3.34542601300938 4.80854279811176 -1.46311678510238 0.428852572648056 0.897442636256404 1.65776231520885 3.41170107962279 1.63031788996078 0.00775167894576411 NA NA NA 0.0108410198923838 54.0702954897606 a167 gain_cnaBRCA30_(CRNKL1,FOXA2) 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 3 23 2.30258509299405 NA 4.38592296555049 2.47053647051543 1.91538649503506 1.34138632542355 1.04759472672477 1.78150958272342 1.42791562634296 1.82836591877793 0.00781979330556721 NA NA NA 0.122358439341361 54.2187944222531 a168 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 87 GW843682X PLK1 3 9 -1.36257783450257 NA 0.372095509795554 -2.67696815768945 3.04906366748501 0.353758979351536 1.53521375886145 2.2059166305783 8.61904247087706 1.98608412013339 0.00789430243311655 NA NA NA 0.000272358211537585 54.4095999244384 a169 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 223 ZSTK474 PI3K 15 34 1.63315443905142 2.32630161961136 0.106384227127263 1.26790578524662 -1.16152155811936 0.693843569606237 1.54907213994801 0.859033665191426 1.6740395227393 0.749817602528401 0.00797243943074926 NA NA NA 0.000709024062478566 54.6230036500862 a170 gain_cnaBRCA27_(CLTC,PPM1D) 1022 AZD7762 CHEK1, CHEK2 10 35 0.693147180559945 NA 2.07097020184171 0.57154510955462 1.49942509228708 1.3816400589195 1.53782561550445 0.995319524597271 1.08525015803298 0.975029338287641 0.00812019939324452 NA NA NA 0.00943813228273966 55.3081110437519 a171 MLL3_mut 225 Genentech Cpd 10 AURKA, AURKB 3 46 2.32630161961136 NA 0.692991030016617 3.16969860450957 -2.47670757449296 1.27268047384705 1.51807984536291 1.64188819928746 1.94605608036587 1.63147385301126 0.00831453302224322 NA NA NA 0.0664548307519197 55.6647206703807 a172 TP53_mut 150 Bicalutamide ANDR (androgen receptor) 38 10 0.0237165266173161 NA 2.88129804779642 2.3114885869466 0.569809460849817 0.588110533174773 0.55623141754281 0.979036008155055 0.968881577029131 1.02441078097852 0.00838808693763444 NA NA NA 0.0123786153656294 55.6647206703807 a173 BRCA2_mut 154 CHIR-99021 GSK3B 6 41 0.940007258491471 NA 2.38781711856852 3.40533243106422 -1.0175153124957 1.23352135200826 0.782381883749304 1.20488021164786 0.824886663566152 1.30053536978591 0.00840760762924168 NA NA NA 0.100607535180358 55.6647206703807 a174 gain_cnaBRCA62 173 FH535 unknown 9 39 3.46573590279973 NA 2.56177530958706 1.34481870726116 1.21695660232589 1.70577807655497 1.05661851491986 1.01827217482029 0.71343196342615 1.15174642990067 0.008412194505874 NA NA NA 0.0689314934385464 55.6647206703807 a175 gain_cnaBRCA64_(SDHC) 1161 ZG-10 IRAK1 6 20 2.30258509299405 NA 3.23689953041154 1.59696391676879 1.63993561364275 1.33802875101474 1.19624336220914 1.33639523475168 1.2256355570828 1.37090467161651 0.00841292522438607 NA NA NA 0.0286339651565061 55.6647206703807 a176 gain_cnaBRCA30_(CRNKL1,FOXA2) 172 Embelin XIAP 5 43 3.46573590279973 NA 4.04395603790285 2.87086521955169 1.17309081835116 1.46556581255541 0.830752165679337 1.29791093502596 0.800435441589426 1.4120827688627 0.00856012449421408 NA NA NA 0.148619207506068 56.3168644991505 a177 gain_cnaBRCA30_(CRNKL1,FOXA2) 1046 681640 WEE1, CHEK1 4 32 0.693147180559945 NA 3.91064955938995 2.47418804912732 1.43646151026262 0.710913756436711 0.993705974693792 1.47773669225031 2.02058477172048 1.44555990086028 0.00865414842650925 NA NA NA 0.0174152563377307 56.3429564041999 a178 BRCA2_mut 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 6 42 2.77258872223978 NA -1.81380144854721 -0.239773737680053 -1.57402771086716 1.61131654610409 1.2742835731081 1.19688070591612 0.976858156563286 1.23522561546324 0.00866140965536539 NA NA NA 0.0622530213221627 56.3429564041999 a179 gain_cnaBRCA30_(CRNKL1,FOXA2) 1164 XMD8-92 MAP2K5 (ERK5) 3 23 2.30258509299405 NA 5.65181236618833 3.65396854594987 1.99784382023846 0.991100047260424 1.15473312933112 1.74943626037362 2.01578420439073 1.73013466877469 0.00883858031996093 NA NA NA 0.054579173268011 56.981731343324 a180 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 167 OSU-03012 PDPK1 (PDK1) 7 41 2.77258872223978 NA 3.30370020631762 2.06773394828837 1.23596625802925 1.56232257277598 1.02097172235286 1.11680000832699 0.791108238187422 1.21057834508965 0.00892637244350613 NA NA NA 0.0836243394714111 56.981731343324 a181 gain_cnaBRCA64_(SDHC) 1219 PFI-1 BRD2, BRD3, BRD4 9 38 2.30258509299405 NA 3.93515990848447 2.99184659889941 0.943313309585053 1.39036880074143 0.798156730695358 1.01281359733613 0.678462656154267 1.18186475576449 0.00895980928321507 NA NA NA 0.0806159861843374 56.981731343324 a182 gain_cnaBRCA30_(CRNKL1,FOXA2) 1243 piperlongumine Increases ROS levels 5 42 2.30258509299405 NA 2.62991516700378 1.60076288763975 1.02915227936403 1.06056922359772 0.766109097446058 1.29176465877509 0.970377280865167 1.34334950830746 0.00899637518469516 NA NA NA 0.0951681398608822 56.981731343324 a183 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 223 ZSTK474 PI3K 7 42 1.63315443905142 2.32630161961136 -0.378586754780259 1.12749208068466 -1.50607883546492 0.62250678687592 1.43165206906515 1.11106832322714 2.41937737421828 1.05198662999759 0.00908419590609508 NA NA NA 0.000166606160497061 56.981731343324 a184 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1019 Bosutinib SRC, ABL, TEC 17 28 0.693147180559945 NA 3.11682953548176 2.38681543127712 0.730014104204639 0.890617893458232 0.856392272245313 0.839787014582186 0.81967149949124 0.852429579135117 0.0091125545511756 NA NA NA 0.010746735536777 56.981731343324 a185 gain_cnaBRCA62 219 AT-7519 CDK9 10 39 2.32630161961136 NA 0.370293613871765 2.00577150067258 -1.63547788680082 2.16142778525383 1.56690219453432 0.963775589635439 0.756665523576009 1.04376513895105 0.00914461814283495 NA NA NA 0.0451287686929769 56.981731343324 a186 gain_cnaBRCA31 306 TG101348 JAK2 16 32 2.32630161961136 NA 3.89120311683633 2.89173183906752 0.999471277768808 1.23201030666601 1.18413627803994 0.832922398512464 0.8112523672578 0.84405088865548 0.0091740282016159 NA NA NA 0.0118902698147009 56.981731343324 a187 gain_cnaBRCA16 1239 YK 4-279 RNA helicase A 15 27 2.30258509299405 NA 2.69264161112774 1.63628136293916 1.05636024818858 1.48638544396926 1.00995910688626 0.881439193122885 0.710690657308694 1.04594358423618 0.009202507782366 NA NA NA 0.0227125040659527 56.981731343324 a188 gain_cnaBRCA13_(FGFR1,WHSC1L1) 192 LFM-A13 BTK 10 38 2.77258872223978 NA 5.39290874878784 4.63824943359732 0.754659315190517 0.844882069733565 0.766991944158512 0.964000315157788 0.893212605906644 0.98392078422476 0.00936522261673883 NA NA NA 0.0235139659419414 57.3836815690755 a189 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 153 Midostaurin KIT 14 33 -0.669430653942629 NA 1.43866748413088 0.261554735030836 1.17711274910005 1.23746839778542 1.40640375730038 0.865678268060128 0.95122651310257 0.83696644223956 0.00938671147451241 NA NA NA 0.0079413290407657 57.3836815690755 a190 POLR2B_mut 206 Ruxolitinib JAK1, JAK2, TYK2 3 46 1.65632149833295 0.0237165266173161 3.44287930772327 4.43074183132706 -0.987862523603791 1.58790840279737 0.528623854939094 1.61350008884166 0.622115558972737 1.8687437473241 0.00941609767520887 NA NA NA 0.393951981875345 57.3836815690755 a191 loss_cnaBRCA29_(MAP2K4) 1527 GDC0941 (rescreen) PI3K 7 38 1.38629436111989 NA 1.99632084926175 0.793559655698168 1.20276119356359 1.3801572946702 1.01915251248683 1.11696121742592 0.871466751078539 1.18015819892229 0.00948682587161801 NA NA NA 0.0625930210560754 57.4726872479277 a192 CDH1_mut 261 TL-1-85 MAP3K7 (TAK1) 4 45 2.32630161961136 NA 2.55420302531312 4.15552677177645 -1.60132374646333 1.13433886211489 1.13600667824737 1.40973970463983 1.41168023061273 1.40960768728389 0.00955934080958919 NA NA NA 0.0610491407694908 57.4726872479277 a193 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 346 THZ-2-102-1 CDK7 7 41 0.916290731874155 2.99573227355399 0.914121613298688 -1.71918092560178 2.63330253890047 2.3018949983912 2.39335670113569 1.10567419626735 1.14397161501323 1.10025494221188 0.00957960846260475 NA NA NA 0.0228605429449358 57.4726872479277 a194 loss_cnaBRCA17 165 DMOG Prolyl-4-Hydroxylase 10 36 8.29404964010203 NA 6.48712789064984 7.87077299100035 -1.38364510035051 1.31948972717944 1.46074879362573 0.965566308410028 1.04862135100378 0.947216322469902 0.00977377456095118 NA NA NA 0.0114090183829637 57.77264796394 a195 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 163 JQ1 BRD4 5 42 0.940007258491471 NA -1.23866063315135 0.500985480029021 -1.73964611318037 1.40293864269369 1.35956760727435 1.2758880230667 1.24000156545705 1.27955837125893 0.00981205053769849 NA NA NA 0.0471246828211883 57.77264796394 a196 gain_cnaBRCA58_(CCND1) 133 Doxorubicin DNA intercalating 9 39 0.0237165266173161 NA 0.358136900127622 -1.35113311053277 1.70927001066039 1.44698883821847 1.77081212128947 0.994407487043808 1.18125998315567 0.965246391816953 0.00994783146053447 NA NA NA 0.00848900125683413 57.77264796394 a197 loss_cnaBRCA23 1170 CCT018159 HSP90 3 40 2.30258509299405 NA 5.00673227371883 3.21803562049702 1.78869665322181 0.689108249028366 1.12429766958653 1.6157396077675 2.59566861337656 1.59094579808177 0.0100516848268711 NA NA NA 0.02843334843288 57.77264796394 a198 ASH1L_mut 1028 VX-702 p38 3 42 0.693147180559945 NA 2.46913117283496 3.49523859315983 -1.02610742032487 0.590490409282648 0.63987467095767 1.60916998188561 1.73772072195284 1.60360687318525 0.0100627769053562 NA NA NA 0.0843231063819433 57.77264796394 a199 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1066 AZD6482 PI3Kbeta 5 38 1.6094379124341 NA 0.45083840291044 2.16670727417284 -1.7158688712624 1.40883545747786 1.3288411544269 1.28351041749974 1.21793418965632 1.29125205487966 0.0100812369869988 NA NA NA 0.049778953408576 57.77264796394 a200 gain_cnaBRCA30_(CRNKL1,FOXA2) 207 AS601245 JNK 5 43 2.07944154167984 NA 3.63223148543342 2.10735992567574 1.52487155975769 1.75102147352281 1.1365013416353 1.26811591550455 0.870846864424715 1.34172438156875 0.0100820339229093 NA NA NA 0.123536285766637 57.77264796394 a201 loss_cnaBRCA17 1042 BIRB 0796 p38, JNK2 6 37 2.30258509299405 NA 5.24375134368039 4.22435407529975 1.01939726838064 0.405344775783605 0.903735454679722 1.1872955399171 2.51488937142451 1.12798193664086 0.0100877474710443 NA NA NA 0.000360709570206417 57.77264796394 a202 gain_cnaBRCA31 1033 Vismodegib SMO 14 31 2.30258509299405 NA 5.19499763868404 4.56322221593897 0.631775422745074 0.450658719530984 0.821804441167252 0.865702933204984 1.40189326282776 0.768766133519223 0.0101707085488037 NA NA NA 0.00191281319092136 57.77264796394 a203 loss_cnaBRCA57 1069 EHT 1864 Rac GTPases 4 42 2.30258509299405 NA 4.59058996390702 3.46340566691085 1.12718429699617 0.796432691204565 0.80277605735816 1.4048621088667 1.41529134783677 1.40410801575921 0.0101940488077038 NA NA NA 0.0602912761549085 57.77264796394 a204 gain_cnaBRCA62 229 LY317615 PRKCB (PKCbeta) 10 39 2.99573227355399 2.32630161961136 2.21556570522151 3.65166444810414 -1.43609874288262 1.28459349525906 1.56420282247093 0.948131773578539 1.11794022636944 0.918102641327584 0.0102533573430558 NA NA NA 0.00806873129481422 57.77264796394 a205 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1378 Bleomycin (50 uM) DNA damage 15 33 3.91202300542815 NA 4.82560944892752 3.35231223328115 1.47329721564636 1.79699183826705 1.75465485950295 0.833479141492249 0.819868618361204 0.839650719722574 0.0102731144515474 NA NA NA 0.0133149383410419 57.77264796394 a206 gain_cnaBRCA27_(CLTC,PPM1D) 1378 Bleomycin (50 uM) DNA damage 10 38 3.91202300542815 NA 5.14383502491588 3.46242355744821 1.68141146746767 1.90469292416408 1.73269557815182 0.95120503940139 0.882772989880034 0.970402122951768 0.0102782325594366 NA NA NA 0.0249130747740893 57.77264796394 a207 MLL3_mut 235 QL-XII-47 BTK, BMX 3 46 2.32630161961136 NA -0.398207431111704 1.84544134651186 -2.24364877762356 1.35468057468929 1.41481615555962 1.58863832934766 1.65621979051274 1.58582354944633 0.0104895682413851 NA NA NA 0.0938977383327569 57.8980296364877 a208 loss_cnaBRCA18 276 CAY10603 HDAC6 16 33 2.99573227355399 NA 0.666308064563732 1.42243995427976 -0.75613188971603 0.742617564129859 1.00758982059806 0.8119521517755 1.01819823047413 0.750436213485392 0.0105090218631496 NA NA NA 0.00519649743628766 57.8980296364877 a209 gain_cnaBRCA31 1239 YK 4-279 RNA helicase A 13 29 2.30258509299405 NA 2.75707829685491 1.6802483830055 1.07682991384941 1.55898268898046 1.01133030222992 0.895779474967619 0.690726023746702 1.06476579558139 0.0105372808929988 NA NA NA 0.0357306375352312 57.8980296364877 a210 gain_cnaBRCA14_(RAD21) 64 CMK RSK 6 6 1.38629436111989 NA 1.40333225519556 3.00498069667047 -1.60164844147491 1.05386185318474 0.675188640664669 1.80974076472383 1.51978974913531 2.37214956682064 0.0106078240678707 NA NA NA 0.0128823313843869 57.8980296364877 a211 POLR2B_mut 1262 UNC1215 LMBL3 3 43 0 NA 1.93013815588932 2.81524464616827 -0.885106490278945 0.688897418030676 0.548278128276883 1.59351519766164 1.28481609469399 1.61433849834689 0.010626909751974 NA NA NA 0.150710013415128 57.8980296364877 a212 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 5 9 1.38629436111989 NA 2.59588771816327 1.54541474707324 1.05047297109004 0.218635150422511 0.748101317840552 1.68418250207987 4.80468474104006 1.40418543055412 0.0106733331467695 NA NA NA 0.00276812579687549 57.8980296364877 a213 gain_cnaBRCA14_(RAD21) 17 Cyclopamine SMO 6 7 2.77258872223978 NA 4.12178015784188 5.18752045146079 -1.06574029361891 0.83587455546745 0.363380554072264 1.707405382301 1.27500028161871 2.93284899721677 0.0106799456299694 NA NA NA 0.024605209122503 57.8980296364877 a214 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 154 CHIR-99021 GSK3B 7 40 0.940007258491471 NA 4.06344648236692 3.13753517521189 0.925911307155029 0.800482721866801 0.855745386702855 1.09112382992717 1.15669118378435 1.08199392195676 0.0107005599293621 NA NA NA 0.0218772298276983 57.8980296364877 a215 gain_cnaBRCA63 1239 YK 4-279 RNA helicase A 5 37 2.30258509299405 NA 3.36419725981715 1.83103336938345 1.5331638904337 1.8326327938652 1.11085181640678 1.27478615424236 0.836590884745715 1.38016958498835 0.0107609057682876 NA NA NA 0.135274563286454 57.9537339027917 a216 gain_cnaBRCA62 223 ZSTK474 PI3K 10 39 1.63315443905142 2.32630161961136 -0.105181297995381 1.17324033551918 -1.27842163351456 0.775073810926748 1.46498267839019 0.939853337566503 1.64941921077937 0.872653071174441 0.0108888357347321 NA NA NA 0.000794472676509021 58.371217116881 a217 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1069 EHT 1864 Rac GTPases 6 40 2.30258509299405 NA 2.75016509338828 3.68311018263885 -0.932945089250568 0.704008560316073 0.815652990771884 1.16074398928268 1.32518997898507 1.14380146925923 0.0111034391034271 NA NA NA 0.0204569489785858 59.0856325906131 a218 loss_cnaBRCA33 345 KIN001-270 CDK9 6 43 2.99573227355399 NA 4.45167172473526 5.19911004819173 -0.74743832345647 0.585819653686774 0.655975836014103 1.15190222298696 1.27588468354138 1.13942965947971 0.0111241626260935 NA NA NA 0.0240016051551105 59.0856325906131 a219 TP53_mut 6 PHA-665752 MET 9 5 0.693147180559945 NA 3.21739581793584 2.22898764620002 0.988408171735816 0.463234918015929 0.790671812387107 1.66727647949677 2.13370826182371 1.25008651661898 0.011291791536157 NA NA NA 0.0457682423032274 59.2365074306807 a220 loss_cnaBRCA33 329 QL-XI-92 DDR1 6 42 2.32630161961136 NA 3.35854789968393 4.38116184083676 -1.02261394115282 0.931129008256904 0.883816463593967 1.15019196860988 1.09825161936173 1.15704332661382 0.0114155878023566 NA NA NA 0.0423941757464635 59.2365074306807 a221 gain_cnaBRCA48 152 CP466722 ATM 5 44 2.77258872223978 NA 3.84359758765898 2.60361268942931 1.23998489822966 1.25708852995348 0.970581543112095 1.24225589952928 0.986394250431627 1.27756900698291 0.0114405335243727 NA NA NA 0.0912564140927514 59.2365074306807 a222 gain_cnaBRCA30_(CRNKL1,FOXA2) 1038 NU-7441 PRKDC (DNAPK) 4 39 0.693147180559945 NA 4.00249953737631 2.77905634678025 1.22344319059606 0.936582852435438 0.876027766862318 1.38932934106374 1.3062839954999 1.39658037892804 0.0114908247173314 NA NA NA 0.0742814441370646 59.2365074306807 a223 loss_cnaBRCA18 274 PXD101, Belinostat HDAC 16 32 2.99573227355399 NA -0.0835016239106091 1.04900583090411 -1.13250745481471 0.822478417582807 1.61295758907853 0.806088378282676 1.37694489071586 0.702130956500666 0.0114958873477679 NA NA NA 0.00234480309073831 59.2365074306807 a224 ASH1L_mut 194 AUY922 HSP90 3 44 -1.36257783450257 NA -4.77749716003048 -2.2312186599117 -2.54627850011878 0.150717390439859 1.65752740061291 1.57120815677519 16.8943908376308 1.53619089444749 0.0115540043398308 NA NA NA 4.39173512768876e-12 59.2365074306807 a225 gain_cnaBRCA30_(CRNKL1,FOXA2) 1239 YK 4-279 RNA helicase A 4 38 2.30258509299405 NA 3.53001247409207 1.85392555447119 1.67608691962089 2.26089257052593 1.07439351931985 1.39137718480272 0.741338594089409 1.56003074244336 0.0115614028835905 NA NA NA 0.2350463898652 59.2365074306807 a226 gain_cnaBRCA16 1243 piperlongumine Increases ROS levels 16 31 2.30258509299405 NA 2.13827793510404 1.48932806949109 0.648949865612958 1.06235429802154 0.630401765598567 0.810468059671404 0.610860112131628 1.02942266507896 0.011561836669258 NA NA NA 0.035681463829929 59.2365074306807 a227 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 104 Bortezomib Proteasome 5 9 -3.91202300542815 NA -3.10135784953233 -5.38880150488926 2.28744365535693 1.46013452964011 1.3398035824993 1.65627248941643 1.56659787774537 1.7072977600865 0.0117134472592665 NA NA NA 0.0207941132079619 59.7489012401087 a228 loss_cnaBRCA20 1011 ABT-263 BCL2, BCL2L1, BCL2L2 3 40 0.693147180559945 NA -0.605799868172984 1.85352803838565 -2.45932790655864 2.12204695847701 1.52393630772731 1.57806306837436 1.1589413216019 1.61379966740625 0.0117848609768895 NA NA NA 0.178316337448046 59.8045420788666 a229 gain_cnaBRCA14_(RAD21) 1239 YK 4-279 RNA helicase A 19 23 2.30258509299405 NA 2.55178159255827 1.56892916120288 0.982852431355395 1.51015116635508 0.881905599144068 0.815086246206503 0.650830495153424 1.11446444189639 0.0120867200948212 NA NA NA 0.0183598595648267 59.8045420788666 a230 loss_cnaBRCA57 176 IPA-3 PAK1, PAK2, PAK3 5 42 3.46573590279973 NA 6.06297825291191 4.31039435441934 1.75258389849257 0.597998537995133 1.47309296319472 1.23651558087418 2.93074947033872 1.18973068386106 0.0121371487377702 NA NA NA 0.000375797900619982 59.8045420788666 a231 gain_cnaBRCA47_(EGFR) 1008 Methotrexate Dihydrofolate reductase (DHFR) 7 38 -1.6094379124341 NA -0.245091897817351 0.853549911444875 -1.09864180926223 1.29194926389269 0.968881456349226 1.0769715746187 0.850375351391105 1.133927997138 0.0121500955130036 NA NA NA 0.0678889318653596 59.8045420788666 a232 gain_cnaBRCA16 1021 Axitinib PDGFR, KIT, VEGFR 15 30 0.693147180559945 NA 3.06719257626043 2.1599315028041 0.907261073456331 1.08893586481312 1.09905165208613 0.827967916826749 0.833163001396815 0.825494481295983 0.0121547647699921 NA NA NA 0.0137609993891183 59.8045420788666 a233 loss_cnaBRCA33 221 TAK-715 p38a 6 43 2.99573227355399 2.32630161961136 3.53667725820418 4.61407952166651 -1.07740226346233 0.749387032570763 0.968749578176961 1.13670484945651 1.43771137827981 1.11215765945399 0.0121604683466816 NA NA NA 0.0141836629160898 59.8045420788666 a234 gain_cnaBRCA30_(CRNKL1,FOXA2) 1061 SB590885 BRAF 4 38 1.6094379124341 NA 5.2776296052321 3.87867823232878 1.39895137290332 1.00707788500776 1.01403811720624 1.38029290767037 1.38911934591091 1.37958460255671 0.0121878284438843 NA NA NA 0.0628518399166745 59.8045420788666 a235 ASH1L_mut 158 PF-562271 FAK 3 42 0.940007258491471 NA 0.575212517555202 2.45882432612505 -1.88361180856985 0.128083074729835 1.23594731721657 1.56034278072139 14.7061726347759 1.52402273327626 0.0123805799505174 NA NA NA 4.05201366268583e-11 59.8045420788666 a236 TP53_mut 277 ABT-869 VEGFR and PDGFR family 37 11 0.0237165266173161 NA 2.78271085304925 2.38285948523307 0.399851367816178 0.446139005511188 0.451121317700644 0.894068363959341 0.896248395403193 0.886349973116351 0.012383036447251 NA NA NA 0.0196431684730053 59.8045420788666 a237 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 175 PAC-1 CASP3 agonist 6 42 0.940007258491471 NA 1.25801883706545 2.56471936675563 -1.30670052969018 1.01230460466789 1.16580594216427 1.13614884747878 1.29081753028169 1.12085595246182 0.0123891396263893 NA NA NA 0.0228593402074919 59.8045420788666 a238 ASH1L_mut 258 STF-62247 stimulates autophagy 3 46 2.32630161961136 NA 3.31340465405774 4.71676279133805 -1.40335813728031 1.15617427211469 0.8927103157632 1.54984220643818 1.21379464249236 1.57201962663615 0.0123908000629762 NA NA NA 0.165804345991466 59.8045420788666 a239 gain_cnaBRCA31 229 LY317615 PRKCB (PKCbeta) 16 33 2.99573227355399 2.32630161961136 2.54743086947835 3.75186898838251 -1.20443811890416 1.71233740586772 1.42114640036821 0.79231427168921 0.703388312827178 0.847511641722555 0.0123931731371752 NA NA NA 0.0221989841999885 59.8045420788666 a240 loss_cnaBRCA18 302 PI-103 PI3Ka, PRKDC (DNAPK) 15 33 2.32630161961136 NA 0.156819027644937 1.57007594656829 -1.41325691892335 1.43608246462244 1.86289229958936 0.810313860855261 0.984105685946738 0.758635869199135 0.0124229878943639 NA NA NA 0.00696151945599643 59.8045420788666 a241 gain_cnaBRCA27_(CLTC,PPM1D) 1377 Afatinib (rescreen) ERBB2, EGFR 10 37 2.30258509299405 NA 1.47075917496855 3.20325660433625 -1.7324974293677 2.19702315677732 1.77610144953439 0.927516009985373 0.788565848304028 0.975449589223568 0.0124901329752032 NA NA NA 0.0396881340610093 59.8045420788666 a242 loss_cnaBRCA28_(GPS2) 170 Shikonin unknown 4 43 2.77258872223978 NA 1.39083013366351 -0.12543591163841 1.51626604530192 1.96936120239852 1.02707617593243 1.35993801524079 0.769927854501875 1.47629365847707 0.0125164298883072 NA NA NA 0.221331731454464 59.8045420788666 a243 TP53_mut 1025 SB 216763 GSK3A, GSK3B 29 10 2.30258509299405 NA 5.0690446627517 4.3674996776732 0.701544985078491 0.690193355520331 0.839076703325668 0.962059891652842 1.0164470281659 0.836091601992915 0.0125710327411244 NA NA NA 0.0326755065943248 59.8045420788666 a244 TP53_mut 1047 Nutlin-3a MDM2 34 9 2.07944154167984 1.38629436111989 4.39908910444403 3.48106520838017 0.918023896063856 0.741145956824679 1.50028924787337 0.977888569390384 1.23865466391665 0.611897937257856 0.0126271668589175 NA NA NA 0.108712495376586 59.8045420788666 a245 PIK3CA_mut 1261 rTRAIL TR10A (DR4), TR10B (DR5) 16 31 -2.30258509299405 NA 0.373387533953661 -0.405892704576047 0.779280238529708 0.738483292501501 1.07350141839695 0.799501068055384 1.05524423699555 0.725923808925564 0.0126540399078697 NA NA NA 0.00566955123845505 59.8045420788666 a246 gain_cnaBRCA31 226 GSK1070916 AURKB 16 33 0.940007258491471 2.32630161961136 3.37948485086322 1.9309600041649 1.44852484669832 0.732062017404359 2.16747419505514 0.789104255422973 1.97869143905908 0.668300849903068 0.0127290170300975 NA NA NA 0.00123930736379916 59.8756578081604 a247 PIK3CA_mut 326 GSK690693 AKT 16 32 2.32630161961136 NA 1.97903536011147 3.41984969570832 -1.44081433559685 2.38049575455424 1.46757940829381 0.793223527587877 0.60525809921751 0.98176243646804 0.0127902123878992 NA NA NA 0.0376796360626582 59.8756578081604 a248 gain_cnaBRCA62 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 9 36 -0.669430653942629 NA -1.7219771600542 -3.9272450727667 2.20526791271249 2.67093204469199 2.17901479383425 0.967821500647459 0.82565481854736 1.01204815999989 0.0128242189622798 NA NA NA 0.0428951899496314 59.8756578081604 a249 ASH1L_mut 176 IPA-3 PAK1, PAK2, PAK3 3 44 3.46573590279973 NA 2.4437955539628 4.63681971564281 -2.19302416168001 1.43048001604758 1.41852203216575 1.54541097838769 1.5330687161498 1.54599231591192 0.0128904376560329 NA NA NA 0.10882615215961 59.9431235418494 a250 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 258 STF-62247 stimulates autophagy 6 43 2.32630161961136 NA 3.73658028891198 4.75562373558725 -1.01904344667527 0.878423725505214 0.909683642799815 1.12426403083849 1.16008187972062 1.120217401666 0.0130737228365322 NA NA NA 0.0348039444760286 60.3391683176572 a251 gain_cnaBRCA31 1243 piperlongumine Increases ROS levels 15 32 2.30258509299405 NA 2.15209290833327 1.50313198409029 0.648960924242978 0.897059290285081 0.756228866476661 0.808477688401744 0.723431473561509 0.858154129009312 0.0130935570981106 NA NA NA 0.0232260765208866 60.3391683176572 a252 ASH1L_mut 184 BMS-754807 IGF1R 3 45 0.940007258491471 NA -0.652317381645075 1.77881471043487 -2.43113209207995 1.20963821095462 1.59572047895367 1.53781899087983 2.00980100501402 1.52353255106061 0.0131721807630466 NA NA NA 0.0599438234156561 60.3391683176572 a253 gain_cnaBRCA31 1375 Temozolomide DNA akylating agent 14 32 3.40119738166216 NA 6.27767191667856 5.7349495686144 0.542722348064157 0.626011933935703 0.667646311511693 0.827799557273885 0.866952079734474 0.812889008306388 0.0131840483499156 NA NA NA 0.0133995443176658 60.3391683176572 a254 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 111 Salubrinal GADD34-PP1C 4 9 2.77258872223978 NA 4.28842715162939 2.76959553240108 1.51883161922831 1.38185798114573 0.545911296430092 1.76856892680209 1.09912280418934 2.78219488983007 0.0133739589402641 NA NA NA 0.112242578306017 60.9254047190144 a255 gain_cnaBRCA48 225 Genentech Cpd 10 AURKA, AURKB 5 44 2.32630161961136 NA 4.67488126763345 2.82978869453007 1.84509257310338 0.666884294817462 1.57861172012069 1.21194304456295 2.7667356803003 1.16880709143748 0.013467889184252 NA NA NA 0.000625788026121577 60.9254047190144 a256 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 134 Etoposide TOP2 7 40 2.77258872223978 NA 4.29932469536038 2.15821267218954 2.14111202317084 1.25201824005516 2.12627081381132 1.05392577785372 1.71012845873276 1.00697992431778 0.0134699918888226 NA NA NA 0.00270539777657909 60.9254047190144 a257 gain_cnaBRCA63 1004 Vinblastine Microtubules 6 39 -2.30258509299405 NA -2.27810231922816 -3.63670774586907 1.35860542664091 1.13231996964075 1.21352537515689 1.12806855602109 1.19984232643353 1.11955254867684 0.0136364018327652 NA NA NA 0.0306679517635365 61.1357498332412 a258 loss_cnaBRCA18 165 DMOG Prolyl-4-Hydroxylase 15 31 8.29404964010203 NA 6.78440857263845 7.9500960642882 -1.16568749164975 1.17284200530077 1.55285837161401 0.807910713285077 0.993899848727551 0.750672123716062 0.0136777733881522 NA NA NA 0.00755599587177306 61.1357498332412 a259 loss_cnaBRCA20 1006 Cytarabine DNA synthesis 3 42 0.693147180559945 NA 3.26506878213106 1.06163788141275 2.20343090071831 0.854210613928994 1.45697632383203 1.53595463866911 2.57949370423237 1.51233130194114 0.0137131022713349 NA NA NA 0.0284068945696262 61.1357498332412 a260 loss_cnaBRCA33 277 ABT-869 VEGFR and PDGFR family 6 42 0.0237165266173161 NA 2.25289655901905 2.75367563205409 -0.500779073035042 0.37674150846838 0.45612202487989 1.11737323246829 1.32923785083021 1.0979059236767 0.0138094438725799 NA NA NA 0.020175424551429 61.1357498332412 a261 gain_cnaBRCA27_(CLTC,PPM1D) 1003 Camptothecin TOP1 10 35 -2.30258509299405 NA -1.46183260849416 -2.83426682561089 1.37243421711673 1.76699123169652 1.40917260796274 0.920363817288076 0.776706863337984 0.973929105179583 0.0138288599414494 NA NA NA 0.0424961168637488 61.1357498332412 a262 BRCA2_mut 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 6 40 1.63315443905142 NA 0.475421699322785 2.15577096499752 -1.68034926567474 1.64633443761764 1.47660076031926 1.12258407051809 1.0206609466946 1.13798483031488 0.0138332899700399 NA NA NA 0.0543695839996329 61.1357498332412 a263 loss_cnaBRCA60 1527 GDC0941 (rescreen) PI3K 3 42 1.38629436111989 NA 2.52992648849658 0.869993652282689 1.65993283621389 0.236081929344156 1.11075183670752 1.52875464981096 7.0311727832166 1.49442276965686 0.0141308557163572 NA NA NA 6.91341140505511e-06 61.9850695151976 a264 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1059 AZD8055 MTORC1/2 5 38 0.693147180559945 NA 1.14718937845474 -0.00335329856196715 1.15054267701671 1.0926501081208 0.925930579171245 1.21944928545576 1.05298362986068 1.24257984658688 0.014132531610685 NA NA NA 0.0765914551342519 61.9850695151976 a265 loss_cnaBRCA17 55 A-770041 SRC family 3 9 1.63315443905142 NA 4.03968004988491 2.26002514330003 1.77965490658488 0.30893587669849 0.995310850007413 1.97544032145713 5.76059642409795 1.78803929101308 0.0142110853653489 NA NA NA 0.000818914567599003 62.0943990359905 a266 gain_cnaBRCA63 202 GSK-1904529A IGF1R 6 42 0.0237165266173161 NA 2.9536357339231 2.08053709504258 0.873098638880521 0.974978339957176 0.759313599050525 1.11133782286349 0.895505677509584 1.14985249832517 0.0142966123196186 NA NA NA 0.0808002843670528 62.2332609206255 a267 CDH1_mut 265 Tubastatin A HDAC6 4 45 2.99573227355399 NA 3.50335400493872 4.79739553672821 -1.29404153178949 1.02554342916178 0.974626260485823 1.32321105572123 1.26181056305647 1.32773103317004 0.014591969281478 NA NA NA 0.0812708373569664 62.8917494570597 a268 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 269 NSC-207895 MDM4 6 43 2.99573227355399 NA 3.51533010258775 4.75584178976111 -1.24051168717336 1.05527412769703 1.13015414933472 1.10520609849793 1.17553501466068 1.09764821719551 0.0145945829206673 NA NA NA 0.0331309586012389 62.8917494570597 a269 gain_cnaBRCA48 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 5 43 0.246860077931526 2.32630161961136 1.41054829389766 -0.459777471975126 1.87032576587279 2.25714604975004 1.47692947561597 1.19866606356814 0.828624167266407 1.26636091753315 0.0146415054890367 NA NA NA 0.138166502848523 62.8917494570597 a270 gain_cnaBRCA31 330 XMD13-2 RIPK 16 32 2.32630161961136 NA 4.31541567200922 3.42382403048432 0.891591641524897 1.11686455132403 1.16296855301997 0.776554371128236 0.798298809347943 0.766651548066053 0.0146651458272788 NA NA NA 0.0151091340035578 62.8917494570597 a271 loss_cnaBRCA33 1262 UNC1215 LMBL3 5 41 0 NA 2.15862375859071 2.83055647463293 -0.671932716042214 0.44081843609657 0.5696999822747 1.20157012140391 1.52428451494033 1.1794501262916 0.0148174963173497 NA NA NA 0.0220313883668995 63.1681106120155 a272 ASH1L_mut 133 Doxorubicin DNA intercalating 3 45 0.0237165266173161 NA -3.48173428153137 -0.867239030334115 -2.61449525119726 0.367171344059784 1.76956081252747 1.50921254906626 7.12064079480984 1.47748256668442 0.0148563472316446 NA NA NA 6.21916959784098e-06 63.1681106120155 a273 gain_cnaBRCA58_(CCND1) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 9 38 2.99573227355399 NA 4.86920141381592 3.60571889970891 1.26348251410702 1.4675096993025 1.3182032040781 0.938723846373118 0.860970469024868 0.958488425910515 0.0148932500190692 NA NA NA 0.0368822948658857 63.1681106120155 a274 CDH1_mut 287 KIN001-244 PDPK1 (PDK1) 4 45 2.99573227355399 NA 2.39964736043294 3.57396903576156 -1.17432167532862 0.80922225427558 0.89653994070817 1.31765320924064 1.45117323346462 1.3098375454428 0.0149859699900072 NA NA NA 0.0558920974629273 63.3293965380633 a275 gain_cnaBRCA48 223 ZSTK474 PI3K 5 44 1.63315443905142 2.32630161961136 2.37597790298522 0.746015240690181 1.62996266229504 1.72501903306145 1.3306608563947 1.19092367400382 0.944895465531348 1.2249271889693 0.0150605853165677 NA NA NA 0.101748578865329 63.4132790474682 a276 loss_cnaBRCA20 206 Ruxolitinib JAK1, JAK2, TYK2 3 46 1.65632149833295 0.0237165266173161 3.49974046451823 4.42703349501434 -0.927293030496114 1.61004694460429 0.53250020020685 1.50072017588581 0.575941610649135 1.74139470771261 0.0152485049309534 NA NA NA 0.423691187412999 63.9718980418512 a277 gain_cnaBRCA30_(CRNKL1,FOXA2) 1009 ATRA Retinoic acid and retinoid X receptor agonist 5 40 2.30258509299405 NA 5.26327632642893 3.96130768973043 1.3019686366985 0.571591867648371 1.12883011460707 1.19546613477695 2.27779419265538 1.15337872355726 0.0155193113786765 NA NA NA 0.00261366458579891 64.7000161804694 a278 TP53_mut 34 Imatinib ABL, KIT, PDGFR 9 5 0.693147180559945 NA 2.98971008021363 2.39524517095173 0.594464909261903 0.346224856987054 0.435370758566702 1.57148760140603 1.71699084356653 1.36542222362145 0.015533815094715 NA NA NA 0.0346197742911227 64.7000161804694 a279 PTEN_mut 1066 AZD6482 PI3Kbeta 8 35 1.6094379124341 NA 0.881068180132042 2.21544351405896 -1.33437533392692 1.19569625680489 1.37927616204346 0.988644377006605 1.11598186105609 0.967446092847701 0.0156163237908551 NA NA NA 0.0175275170282131 64.8105423563839 a280 gain_cnaBRCA30_(CRNKL1,FOXA2) 1143 HG-5-88-01 EGFR, ADCK4 3 23 2.30258509299405 NA 5.7719942901657 4.37260958089401 1.39938470927168 0.841091189458399 0.879911804277948 1.59611842210711 1.66377287838764 1.59036928754469 0.015698125162619 NA NA NA 0.0862057394675489 64.9173540207019 a281 loss_cnaBRCA17 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 10 38 0.246860077931526 2.32630161961136 -1.36672322509646 0.0249879585663814 -1.39171118366284 1.23620133045184 1.63224053014594 0.89059685029658 1.12579654250506 0.85263854068028 0.0158171349995696 NA NA NA 0.00853206029560946 64.9765428509998 a282 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 17 Cyclopamine SMO 4 9 2.77258872223978 NA 5.45946476314525 4.35616278385509 1.10330197929016 0.110888924512296 0.753940823835381 1.70904726513059 9.94961385136179 1.46338007494744 0.0159664436086163 NA NA NA 0.00216905497657349 64.9765428509998 a283 gain_cnaBRCA30_(CRNKL1,FOXA2) 1129 PF-4708671 RPS6KB1 (p70S6KA) 4 39 2.30258509299405 NA 5.09491966250376 3.67707433471495 1.41784532778881 1.66151405090852 1.01420706039593 1.31908363307768 0.853345373163433 1.39798408348223 0.0160171693738055 NA NA NA 0.185917947132606 64.9765428509998 a284 gain_cnaBRCA19 346 THZ-2-102-1 CDK7 4 44 0.916290731874155 2.99573227355399 -4.21468708925211 -1.07338223408122 -3.14130485517088 1.03077643808178 2.47316004071416 1.3058301771752 3.0475132522593 1.27015834133556 0.0160286929115689 NA NA NA 0.00180095472655446 64.9765428509998 a285 gain_cnaBRCA31 230 GSK429286A ROCK2 16 33 2.99573227355399 2.32630161961136 5.84066505797582 5.19451620567108 0.646148852304743 0.597607580693042 0.944173982955372 0.76100041960262 1.08122599709229 0.68435358733591 0.016043750788683 NA NA NA 0.00569336514499622 64.9765428509998 a286 gain_cnaBRCA19 211 TL-2-105 CRAF 4 45 2.32630161961136 1.63315443905142 2.67457568489721 4.01715178555279 -1.34257610065558 0.662817381898456 1.05051935927354 1.30329315464997 2.02555958446676 1.27801176513683 0.0160491331335918 NA NA NA 0.0176990306722643 64.9765428509998 a287 gain_cnaBRCA16 1164 XMD8-92 MAP2K5 (ERK5) 10 16 2.30258509299405 NA 4.6345507306112 3.41570039683124 1.21885033377996 1.14712410488253 1.18058975674803 1.04340001792393 1.06252699999254 1.0324080204942 0.016122875515789 NA NA NA 0.0170333028249711 65.0448222445333 a288 gain_cnaBRCA14_(RAD21) 88 MS-275 HDAC 6 8 1.6094379124341 NA -0.0890250367651627 2.06032036709527 -2.14934540386043 0.477718157585805 1.81973639792628 1.50974889212359 4.49919135316596 1.18113008362626 0.0161783477039689 NA NA NA 0.0121731873839112 65.0448222445333 a289 loss_cnaBRCA36_(FAT1,IRF2) 310 YM201636 FYV1 9 40 1.63315443905142 NA 3.13618878546142 2.25232519092549 0.88386359453593 0.97898161947539 0.95983291879258 0.917709492833436 0.902839825541943 0.920851511998343 0.0164706931683783 NA NA NA 0.0306900933467465 65.9047403208738 a290 loss_cnaBRCA38 206 Ruxolitinib JAK1, JAK2, TYK2 4 45 1.65632149833295 0.0237165266173161 3.63329350401725 4.43576862551434 -0.802475121497091 1.26769068363898 0.547297387825114 1.29669132632548 0.633021234480904 1.46625059674781 0.0165604968637454 NA NA NA 0.295533919865436 65.9047403208738 a291 gain_cnaBRCA30_(CRNKL1,FOXA2) 1001 AICAR AAPK1 (AMPK) agonist 5 40 7.60090245954208 NA 9.10651576115518 7.56747923751779 1.53903652363739 1.3963255883053 1.29088401301277 1.18291602693309 1.10220462657659 1.1922345525416 0.0165629842243495 NA NA NA 0.0672734584827308 65.9047403208738 a292 loss_cnaBRCA17 1033 Vismodegib SMO 8 37 2.30258509299405 NA 4.17111498913648 4.88705231682683 -0.715937327690358 0.774594281413025 0.729898264239322 0.970948098569239 0.924273964925658 0.98087276373576 0.0167097386210823 NA NA NA 0.0379627389482887 66.260980648463 a293 gain_cnaBRCA48 228 KIN001-102 AKT1 5 44 2.32630161961136 NA 3.34324231162552 1.78466510556586 1.55857720605966 1.87069566364734 1.27125870963043 1.16938995700561 0.833153802805565 1.22601103477416 0.016868046259103 NA NA NA 0.136567314721165 66.66044629152 a294 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 230 GSK429286A ROCK2 6 43 2.99573227355399 2.32630161961136 4.60214586986806 5.51760001152442 -0.91545414165636 0.841437757306948 0.851190225692547 1.07680465431412 1.08796418238505 1.0754988885258 0.0171609649862117 NA NA NA 0.043889570603631 67.5305563481647 a295 gain_cnaBRCA30_(CRNKL1,FOXA2) 1218 JQ1 BRD2, BRD3, BRD4 5 41 0 NA 3.15103073485154 2.37346371800193 0.777567016849612 0.85200405959674 0.64098808664705 1.17288471800914 0.912632995220282 1.21307561411476 0.017204865811131 NA NA NA 0.110810242700518 67.5305563481647 a296 gain_cnaBRCA30_(CRNKL1,FOXA2) 1264 SGC0946 Q8TEK3 (DOT1L) 5 41 -0.693147180559945 NA 2.54835007982849 1.87783117350314 0.670518906325355 0.591639652477744 0.571482415561766 1.16948760250478 1.13332313599548 1.17329752948957 0.0175095879369993 NA NA NA 0.0619766378352254 68.2902639505635 a297 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1001 AICAR AAPK1 (AMPK) agonist 6 39 7.60090245954208 NA 8.96166817882439 7.55030100598824 1.41136717283616 1.595005270538 1.2590373630927 1.08353056373741 0.88486677687284 1.12098910978247 0.0175206360504359 NA NA NA 0.0838501116579323 68.2902639505635 a298 ASH1L_mut 300 CX-5461 RNA Pol I 3 46 2.32630161961136 NA 1.68382141582496 4.05770511131495 -2.37388369548999 2.02401697736953 1.59924408173029 1.465730728532 1.17285760052031 1.48437860274686 0.0176361659949783 NA NA NA 0.174830954769688 68.2902639505635 a299 ARID1A_mut 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 5 42 2.77258872223978 NA 4.00164780841318 5.13105072988139 -1.12940292146821 1.55205149719182 0.892490667987617 1.16497859636174 0.727683922544889 1.26545067862141 0.0176902552280323 NA NA NA 0.180437938575375 68.2902639505635 a300 gain_cnaBRCA62 186 Bexarotene Retinioic acid X family agonist 9 38 2.07944154167984 NA 4.39945441161244 3.4161043952698 0.983350016342643 1.04547360773298 1.08584853746026 0.911537946695083 0.940578517782917 0.905605139592164 0.0178479569810441 NA NA NA 0.02639654311558 68.2902639505635 a301 loss_cnaBRCA33 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 38 1.6094379124341 NA 1.00231704850044 2.77326565415565 -1.77094860565521 2.36146408796758 1.38566746476997 1.17366327482831 0.7499367086202 1.27804733147083 0.0178882762160138 NA NA NA 0.170259722431307 68.2902639505635 a302 ARID1A_mut 1059 AZD8055 MTORC1/2 4 39 0.693147180559945 NA -0.982468135076313 0.244574207364723 -1.22704234244104 0.548930012856076 0.97306142865745 1.29369289435418 2.23533476709854 1.26101220981907 0.0180183379514804 NA NA NA 0.0106923733250147 68.2902639505635 a303 gain_cnaBRCA30_(CRNKL1,FOXA2) 1033 Vismodegib SMO 5 40 2.30258509299405 NA 5.52548597422637 4.66406064411382 0.861425330112554 0.850679294480059 0.726034843010523 1.16642482653262 1.01263229950726 1.18647932451923 0.018031326493368 NA NA NA 0.0851606031627731 68.2902639505635 a304 gain_cnaBRCA30_(CRNKL1,FOXA2) 230 GSK429286A ROCK2 5 44 2.99573227355399 2.32630161961136 6.28872507348957 5.30513750789343 0.983587565596144 0.870414977551809 0.849194347395322 1.15577360917867 1.13002141617858 1.15825967119663 0.0181101408520814 NA NA NA 0.0625551567875166 68.2902639505635 a305 loss_cnaBRCA18 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 15 33 0.246860077931526 2.32630161961136 -1.08700597075489 0.108709082905491 -1.19571505366038 1.16373913756032 1.7135378000531 0.763173789752768 1.02747687610394 0.69780488858975 0.0181156724390911 NA NA NA 0.00745166958589224 68.2902639505635 a306 gain_cnaBRCA48 211 TL-2-105 CRAF 5 44 2.32630161961136 1.63315443905142 4.97781470924137 3.78593317143767 1.1918815378037 0.434093394395926 1.07146475486045 1.15419557499009 2.74567996931235 1.11238520203021 0.0182593120662228 NA NA NA 0.000635184491285513 68.2902639505635 a307 ARID1A_mut 1054 PD-0332991 CDK4, CDK6 4 38 1.38629436111989 0.693147180559945 1.27092146704478 3.05258718792319 -1.78166572087841 1.21927648507568 1.38983048329032 1.29315038602171 1.46124832446664 1.28193023703182 0.0183081811810607 NA NA NA 0.0537506744920769 68.2902639505635 a308 gain_cnaBRCA62 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 4 22 2.30258509299405 NA 5.72725894907861 4.4964341022628 1.23082484681581 0.717559017247559 0.917650988807005 1.3750865777536 1.71529423675429 1.34127774265895 0.0183901573685951 NA NA NA 0.0297935383656021 68.2902639505635 a309 gain_cnaBRCA63 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 4 22 2.30258509299405 NA 5.72725894907861 4.4964341022628 1.23082484681581 0.717559017247559 0.917650988807005 1.3750865777536 1.71529423675429 1.34127774265895 0.0183901573685951 NA NA NA 0.0297935383656021 68.2902639505635 a310 POLR2B_mut 333 T0901317 LXR 3 45 2.32630161961136 NA 3.74596677526433 4.8014008347474 -1.05543405948307 0.235131400315023 0.739309721610367 1.45633458790231 4.48869890652217 1.42759391447487 0.0184935999402562 NA NA NA 0.00137137398055283 68.2902639505635 a311 loss_cnaBRCA36_(FAT1,IRF2) 228 KIN001-102 AKT1 9 40 2.32630161961136 NA 2.9248404330322 1.72294780764339 1.2018926253888 1.318892965795 1.33846333398544 0.900191293761468 0.911288979894082 0.897964549996316 0.0185139485487772 NA NA NA 0.0298492658542103 68.2902639505635 a312 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 185 OSI-906 IGF1R 7 41 0.940007258491471 NA 3.80549575837317 2.7377815974641 1.06771416090907 0.393255359753037 1.13651648337615 0.99853428175802 2.71506575671236 0.939462098901818 0.0185251724332765 NA NA NA 8.60135058476099e-05 68.2902639505635 a313 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 304 SB52334 ALK5 6 43 2.99573227355399 NA 3.17447932474041 4.45920510918075 -1.28472578444034 1.13649658087417 1.21691502778022 1.06297422259295 1.13042644039646 1.05572349351607 0.0185530748943059 NA NA NA 0.0383349567520025 68.2902639505635 a314 ASH1L_mut 269 NSC-207895 MDM4 3 46 2.99573227355399 NA 3.06677439059434 4.70419248703199 -1.63741809643764 1.3117304274509 1.11875758832691 1.45207247979353 1.24828856765917 1.46360401352574 0.0186565530119171 NA NA NA 0.157633391357443 68.2902639505635 a315 gain_cnaBRCA31 255 CP724714 ERBB2 16 32 2.32630161961136 NA 3.01563526404911 4.19673589580483 -1.18110063175572 2.32087338664749 1.05257604308995 0.746532202278192 0.508903518197442 1.12210480136757 0.0186835790475726 NA NA NA 0.0682892485468646 68.2902639505635 a316 gain_cnaBRCA16 202 GSK-1904529A IGF1R 16 32 0.0237165266173161 NA 2.58250848333129 1.99325739568833 0.58925108764296 0.954099207806358 0.696433594245513 0.746126702977783 0.617599388849459 0.846098023575859 0.0187440880311854 NA NA NA 0.0383842495263243 68.2902639505635 a317 gain_cnaBRCA63 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 6 40 1.63315443905142 NA 3.33447349855701 1.72691319511239 1.60756030344462 1.9398913246583 1.44131777786873 1.06721904235527 0.828685753171137 1.11534064737737 0.0188904661730436 NA NA NA 0.100137232927119 68.2902639505635 a318 BRCA2_mut 178 BAY 61-3606 SYK 6 42 2.07944154167984 NA 1.67994947809517 3.29801044216966 -1.61806096407449 0.485021372757533 1.60495167621251 1.0619762866946 3.33606116133645 1.00816802652459 0.0189069865381641 NA NA NA 2.75564533254536e-05 68.2902639505635 a319 gain_cnaBRCA27_(CLTC,PPM1D) 200 LAQ824 HDAC 9 39 0.0237165266173161 NA -3.66240920042888 -2.45878853514409 -1.20362066528479 0.464004388374512 1.4566593394807 0.8995576150239 2.59398552134664 0.826288365894719 0.0189412564627518 NA NA NA 0.000102517075855185 68.2902639505635 a320 gain_cnaBRCA30_(CRNKL1,FOXA2) 153 Midostaurin KIT 5 42 -0.669430653942629 NA 2.02994291829572 0.44340324862789 1.58653966966783 0.605650757279544 1.43228069091408 1.15048699172473 2.61956193499077 1.10770163958246 0.0190635000317581 NA NA NA 0.000920535462013331 68.2902639505635 a321 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 178 BAY 61-3606 SYK 7 41 2.07944154167984 NA 4.38868501330595 2.87500830113549 1.51367671217046 1.23602123272135 1.56257775991796 0.993254241790442 1.22463649660596 0.968704886885076 0.0191180911422114 NA NA NA 0.0172601624939175 68.2902639505635 a322 gain_cnaBRCA31 1026 17-AAG HSP90 13 30 0 NA -1.84560382795603 -0.484801206542775 -1.36080262141325 1.24246888709891 1.83602800631274 0.808030249188823 1.09524080284267 0.741166592630647 0.0194008934107487 NA NA NA 0.00783270771595132 68.2902639505635 a323 gain_cnaBRCA62 202 GSK-1904529A IGF1R 9 39 0.0237165266173161 NA 2.76451069679678 2.05701990061939 0.707490796177393 0.859787041317046 0.774932012378346 0.895168044363276 0.822867480176996 0.912971441205572 0.0194967644933345 NA NA NA 0.0442699678439547 68.2902639505635 a324 loss_cnaBRCA28_(GPS2) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 4 44 2.07944154167984 NA 4.49046335856909 3.09828891374783 1.39217444482126 0.996321025246163 1.10886406005218 1.26345980503273 1.39731513191473 1.25549604769023 0.0195603600333526 NA NA NA 0.0616367776546714 68.2902639505635 a325 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 163 JQ1 BRD4 7 40 0.940007258491471 NA 1.48281588718718 0.111709394628798 1.37110649255838 1.66510766816464 1.33344843881262 0.991920093667036 0.823434135084895 1.02824110228011 0.0195708794861911 NA NA NA 0.0754983853521063 68.2902639505635 a326 loss_cnaBRCA33 1264 SGC0946 Q8TEK3 (DOT1L) 5 41 -0.693147180559945 NA 1.36287931827823 2.02240077857024 -0.659521460292008 0.446585100103883 0.585902481486265 1.14772299631146 1.47681026558789 1.12565056665914 0.0195806996596486 NA NA NA 0.0248018921064002 68.2902639505635 a327 gain_cnaBRCA13_(FGFR1,WHSC1L1) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 10 37 0.940007258491471 NA 2.69526954786304 1.67065577040655 1.02461377745649 1.21905867041011 1.18025618039245 0.862383806920889 0.840495869744968 0.868128288144861 0.0196382514891748 NA NA NA 0.0325347335242093 68.2902639505635 a328 gain_cnaBRCA62 204 Tipifarnib Farnesyl-transferase (FNTA) 9 39 2.77258872223978 NA 2.66374271855751 1.37910740648836 1.28463531206916 2.14465343753586 1.2374730042495 0.893976733430345 0.598994359454719 1.03811178721289 0.0196500418764145 NA NA NA 0.116410519771325 68.2902639505635 a329 TP53_mut 156 AZD6482 PI3Kbeta 37 10 1.63315443905142 NA 1.79909634216496 2.99389960314552 -1.19480326098056 1.5018522978698 0.761660094239814 0.862168679910092 0.795553106437466 1.56868302542889 0.0196670143968122 NA NA NA 0.00164151635904266 68.2902639505635 a330 gain_cnaBRCA10_(MDM2,NUP107) 140 Vinorelbine Microtubules 4 43 -2.74887219562247 NA -1.79547755234662 -3.76766265650855 1.97218510416192 1.37947700253503 1.5729386545903 1.26358341187822 1.42966145904403 1.25382200914607 0.0197534646593926 NA NA NA 0.0576690916429094 68.2902639505635 a331 gain_cnaBRCA62 1059 AZD8055 MTORC1/2 7 36 0.693147180559945 NA 0.927558986389765 -0.0245664266058171 0.952125412995582 0.697442573278243 0.987279001814544 1.00181432015243 1.36516675275533 0.96439346045611 0.0197886203138899 NA NA NA 0.0104761836958048 68.2902639505635 a332 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 173 FH535 unknown 7 41 3.46573590279973 NA 2.59763010383984 1.39806089372171 1.19956921011813 2.01331151719827 1.04412145944805 0.987141508428968 0.59581897777422 1.14887899225083 0.0198258749852278 NA NA NA 0.169951999331071 68.2902639505635 a333 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 163 JQ1 BRD4 9 38 0.940007258491471 NA 1.31671805204141 0.0788848559760383 1.23783319606537 1.66932852135866 1.31249421729871 0.89524302066077 0.741515633518262 0.943115161766581 0.0198640413700295 NA NA NA 0.0632262365202487 68.2902639505635 a334 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1527 GDC0941 (rescreen) PI3K 13 32 1.38629436111989 NA 0.362157108898099 1.23192095142773 -0.869763842529631 0.699411235266461 1.21213814832511 0.795387949658601 1.24356572882086 0.71754514428198 0.0198989594626395 NA NA NA 0.00466194518770327 68.2902639505635 a335 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 165 DMOG Prolyl-4-Hydroxylase 7 39 8.29404964010203 NA 8.79202499514769 7.35063927221736 1.44138572293033 1.56744650484026 1.43511846054947 0.991411312395486 0.919575703846571 1.00436706972501 0.0199477322419114 NA NA NA 0.0533819683792717 68.2902639505635 a336 loss_cnaBRCA18 305 TPCA-1 IKK 16 33 2.99573227355399 NA 3.52964843075364 4.49283687955185 -0.963188448798211 1.4146774613287 1.2618714020553 0.733816796218023 0.680853745908667 0.763301590977808 0.0199763257713762 NA NA NA 0.0285701805183599 68.2902639505635 a337 TP53_mut 206 Ruxolitinib JAK1, JAK2, TYK2 38 11 1.65632149833295 0.0237165266173161 4.48524359043688 3.97304597523756 0.512197615199311 0.537507194991869 0.862463431450151 0.82472384326936 0.952913039995787 0.593877486884399 0.0199784584640031 NA NA NA 0.085775256837348 68.2902639505635 a338 loss_cnaBRCA57 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 5 42 2.32630161961136 NA 2.89876273368491 1.24052836445761 1.6582343692273 1.12881771815472 1.48138536078357 1.14084578363517 1.46900101102064 1.11938082630315 0.020029729734006 NA NA NA 0.0253533033073054 68.2902639505635 a339 gain_cnaBRCA63 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 5 38 -1.38629436111989 0.693147180559945 -1.30691613112971 -2.34072102112061 1.0338048899909 1.09203497182043 0.875124518557915 1.15046884292304 0.946677456920215 1.18132319237778 0.020118412926984 NA NA NA 0.10137170060149 68.2902639505635 a340 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 14 32 1.38629436111989 NA 3.61286507086782 2.52862231970078 1.08424275116704 1.0076803771543 1.53912327300969 0.772685460699738 1.07597882795828 0.704454782914722 0.0201342129813202 NA NA NA 0.00744223021646501 68.2902639505635 a341 gain_cnaBRCA31 1133 JNJ-26854165 MDM2 13 30 2.30258509299405 NA 3.42976261386198 2.76907215320808 0.660690460653899 0.927483194721766 0.775741484331183 0.802729840418322 0.712347635422223 0.851688963396773 0.020158700333387 NA NA NA 0.0360937875389119 68.2902639505635 a342 ASH1L_mut 151 QS11 ARFGAP 3 45 2.32630161961136 NA 1.86867040621057 3.88656852519193 -2.01789811898136 1.09752059100039 1.41856310355473 1.43507249630883 1.83859704822672 1.42249443392738 0.0201703690051755 NA NA NA 0.0726824732910191 68.2902639505635 a343 gain_cnaBRCA48 256 JW-7-24-1 LCK 5 43 2.32630161961136 NA 2.96222480684365 1.70679521256945 1.25542959427421 1.28390491609438 1.08673198261731 1.1358530423358 0.977821315688393 1.15523387031511 0.0203059779074667 NA NA NA 0.0933360396218761 68.5489557406871 a344 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 16 27 0.693147180559945 NA 3.33918255846988 2.65315121798783 0.686031340482051 0.841608444494343 0.935260544780457 0.76046058875101 0.81514312857713 0.733518958231142 0.0205058563416056 NA NA NA 0.0182939872678563 68.6326618013977 a345 gain_cnaBRCA30_(CRNKL1,FOXA2) 1005 Cisplatin DNA crosslinker 5 40 1.79175946922805 2.30258509299405 4.80536395503779 3.5281735011547 1.27719045388309 1.23065995411319 1.10724508343778 1.14106205916641 1.03780938805588 1.15348487248881 0.0205207435609456 NA NA NA 0.0796866619821357 68.6326618013977 a346 gain_cnaBRCA58_(CCND1) 279 BIX02189 MAP2K5 (MEK5) 10 39 2.99573227355399 NA 5.60626849426192 4.8789169548743 0.727351539387626 0.833059322344378 0.861167685810713 0.849852015602447 0.873108936997101 0.844610813169201 0.0205282876870829 NA NA NA 0.0278806054946267 68.6326618013977 a347 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 201 Epothilone B Microtubules 7 41 -3.44201937618241 NA -2.79946059776335 -4.48097941962839 1.68151882186503 1.86669915468815 1.69012644487333 0.98094106789045 0.900797976814826 0.994907112994763 0.0205678673849944 NA NA NA 0.0570501588671789 68.6326618013977 a348 loss_cnaBRCA17 140 Vinorelbine Microtubules 10 37 -2.74887219562247 NA -4.6505620381295 -3.31583200156646 -1.33473003656304 0.656627300583862 1.71554580327766 0.854349089576009 2.03270566937473 0.778020635772564 0.0207386595272625 NA NA NA 0.000475308379372826 68.9367607293507 a349 gain_cnaBRCA62 172 Embelin XIAP 9 39 3.46573590279973 NA 3.65459154046738 2.84040155810335 0.814189982364027 1.28945635985179 0.820665490517092 0.885445526009456 0.631421122664134 0.992109442607383 0.0207798216645876 NA NA NA 0.10157905267616 68.9367607293507 a350 gain_cnaBRCA15 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 20 23 1.6094379124341 NA 3.16180553406609 2.05041606169978 1.11138947236631 1.32120589610837 1.66278722621182 0.734024068334203 0.841193242960788 0.668389469708815 0.0209806294027157 NA NA NA 0.0191381006993156 68.9367607293507 a351 loss_cnaBRCA17 219 AT-7519 CDK9 11 38 2.32630161961136 NA 0.578803407668357 1.98845229422622 -1.40964888655787 1.46349744390185 1.78781522295001 0.817695552404634 0.963205567889194 0.78847571519827 0.0209980667616654 NA NA NA 0.0149217659834366 68.9367607293507 a352 loss_cnaBRCA7_(FAS,PTEN) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 4 39 0.693147180559945 NA -0.121666108223978 1.86693298368726 -1.98859909191124 2.06086954182458 1.53357009768934 1.26009162186417 0.964932059770577 1.29671222391953 0.0210151967940834 NA NA NA 0.147438938495032 68.9367607293507 a353 loss_cnaBRCA17 163 JQ1 BRD4 10 37 0.940007258491471 NA -0.612920823195746 0.566953925065395 -1.17987474826114 1.36888601674875 1.38801063453758 0.85238326089212 0.861923296625873 0.850047340346368 0.0210162160268251 NA NA NA 0.029764768297582 68.9367607293507 a354 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 83 JW-7-52-1 MTOR 3 9 0.182321556793955 NA 0.318747934456813 -2.79946974014365 3.11821767460047 2.17497021720983 1.57452087845108 1.82187128845404 1.43368293042683 1.98042319874982 0.0210915471107231 NA NA NA 0.114223503803969 68.937713135052 a355 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 225 Genentech Cpd 10 AURKA, AURKB 6 43 2.32630161961136 NA 1.61725121746467 3.21352561843494 -1.59627440097026 1.36846119081101 1.55410806579863 1.03962985069149 1.16647400137394 1.02713217703426 0.0211355800699054 NA NA NA 0.0341797848382946 68.937713135052 a356 loss_cnaBRCA33 341 EX-527 SIRT1 6 43 2.99573227355399 NA 5.07406839801207 5.72096507704058 -0.646896679028511 0.597146016398883 0.625848498865824 1.03859429562916 1.08331406601295 1.03363143029157 0.0212572911412424 NA NA NA 0.0446318959934724 69.1399365518106 a357 gain_cnaBRCA30_(CRNKL1,FOXA2) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 38 1.38629436111989 0.693147180559945 4.55537329863376 3.31533047318828 1.24004282544548 0.617511429413903 1.00901259517199 1.25884728200008 2.00812935012787 1.22896664657998 0.0214034960380673 NA NA NA 0.0170271115474464 69.1452284394092 a358 loss_cnaBRCA17 156 AZD6482 PI3Kbeta 10 37 1.63315443905142 NA 1.12491878759722 2.30422629231315 -1.17930750471593 1.24513507764957 1.42163508206504 0.84956463151642 0.947132183394996 0.829543051936293 0.0214200171775407 NA NA NA 0.0203507357646128 69.1452284394092 a359 ASH1L_mut 341 EX-527 SIRT1 3 46 2.99573227355399 NA 4.81268295459606 5.69582303993542 -0.883140085339359 0.555388400961709 0.625809266751284 1.41761763217972 1.59013058934993 1.41119688099848 0.0214714284778433 NA NA NA 0.100058235168781 69.1452284394092 a360 CDH1_mut 258 STF-62247 stimulates autophagy 4 45 2.32630161961136 NA 3.5882840281531 4.72351480558025 -1.13523077742715 1.04242021305378 0.905636622136883 1.24071833357887 1.08903373439151 1.25351686281031 0.0215251813910058 NA NA NA 0.114478140662065 69.1452284394092 a361 gain_cnaBRCA27_(CLTC,PPM1D) 165 DMOG Prolyl-4-Hydroxylase 9 37 8.29404964010203 NA 8.60732043403899 7.31765466692324 1.28966576711575 1.83628297605497 1.35727449618174 0.885677405163895 0.702324088352896 0.950187873376984 0.021557498459821 NA NA NA 0.0752932561344395 69.1452284394092 a362 ASH1L_mut 1020 Lenalidomide TNFA 3 42 1.6094379124341 NA 3.36028403253685 4.31861533005181 -0.958331297514957 0.339503378375921 0.685134489701354 1.4239561469971 2.82274451022938 1.39874916811251 0.0216754358837105 NA NA NA 0.0187638466555272 69.3314563805204 a363 gain_cnaBRCA48 203 BMS-345541 IKBKB 5 44 2.77258872223978 NA 4.49751563575665 3.42265220335568 1.07486343240097 1.01955754273879 0.954072414541342 1.11985988137976 1.05424499093364 1.12660571254196 0.0217920911645211 NA NA NA 0.0763116898690375 69.5125684831928 a364 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1022 AZD7762 CHEK1, CHEK2 15 30 0.693147180559945 NA 1.67591138289657 0.519170336979339 1.15674104591723 1.61940319731157 1.49687925992918 0.752184150647941 0.714300828748258 0.772768436895811 0.0218898526434161 NA NA NA 0.0286568795316939 69.6325834500316 a365 gain_cnaBRCA8_(CHD4,WNK1) 186 Bexarotene Retinioic acid X family agonist 3 44 2.07944154167984 NA 2.16824982082497 3.70232516505203 -1.53407534422706 2.05630418687248 1.01545747632416 1.41628556546191 0.746035218923664 1.5107233734496 0.0219503000610253 NA NA NA 0.324943067611469 69.6335683305786 a366 loss_cnaBRCA18 346 THZ-2-102-1 CDK7 15 33 0.916290731874155 2.99573227355399 -2.5617898737345 -0.777597531835298 -1.7841923418992 1.91398296047498 2.61166228427604 0.737054564507136 0.932188205822076 0.683163498068352 0.0222016706294976 NA NA NA 0.0116408958164151 70.2385639942494 a367 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 62 BMS-536924 IGF1R 3 9 1.63315443905142 NA 4.27678955470873 2.79378743427897 1.48300212042976 0.0359128527892497 0.922343420983233 1.79730522999449 41.2944671684141 1.60786328247331 0.022468728874693 NA NA NA 0.00130047933948232 70.8897579400736 a368 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 155 AP-24534 ABL 7 40 -0.669430653942629 NA 2.33384021373967 1.28987568166949 1.04396453207018 0.715841965554687 1.12407906745041 0.967877714531475 1.45837291232463 0.928728736527453 0.0225424111532087 NA NA NA 0.0073214050629603 70.9289616149466 a369 MLL3_mut 192 LFM-A13 BTK 3 45 2.77258872223978 NA 3.74560166197462 4.86546135508117 -1.11985969310655 0.557701539361133 0.805522349886676 1.40623566131223 2.00799103834175 1.39022795986244 0.0226632029455048 NA NA NA 0.0579927907435689 71.1157796493225 a370 gain_cnaBRCA64_(SDHC) 1192 GSK269962A ROCK1, ROCK2 9 37 1.6094379124341 NA 3.6454282098119 2.43017712067084 1.21525108914106 1.24969539045381 1.41987093483094 0.873979605648793 0.97243784239274 0.855888418679234 0.0232405191932184 NA NA NA 0.0238434321626008 72.4598466989832 a371 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 185 OSI-906 IGF1R 6 42 0.940007258491471 NA 1.93067068369211 3.0310355167259 -1.10036483303378 1.32694406400324 1.03888308899448 1.02460225736727 0.829247338214174 1.05918061877281 0.0232491427690018 NA NA NA 0.100115786753661 72.4598466989832 a372 POLR2B_mut 221 TAK-715 p38a 3 46 2.99573227355399 2.32630161961136 3.22326213586372 4.56425427333248 -1.34099213746876 0.709902621070646 0.96911666232841 1.39757451377537 1.88898040050385 1.38372622161596 0.0232792667518972 NA NA NA 0.067778195866413 72.4598466989832 a373 gain_cnaBRCA62 167 OSU-03012 PDPK1 (PDK1) 9 39 2.77258872223978 NA 3.04256471367162 2.0646131000257 0.977951613645921 1.42284444480281 1.05487344997992 0.867341293407841 0.687321525004409 0.927079559794154 0.023373083672379 NA NA NA 0.0803974969315239 72.5568192607175 a374 loss_cnaBRCA33 1028 VX-702 p38 5 40 0.693147180559945 NA 2.78389866357903 3.50719802783307 -0.723299364254044 0.498567326063966 0.662416892169819 1.11461565786237 1.45075564811731 1.09190960074221 0.0234430285565867 NA NA NA 0.0264362115357112 72.5793656836143 a375 CDH1_mut 269 NSC-207895 MDM4 4 45 2.99573227355399 NA 3.33407720583231 4.71681930559834 -1.38274209976602 1.42265257545692 1.1100743487579 1.22084949849051 0.971946435567322 1.24563017000908 0.0235864567186027 NA NA NA 0.145392099045658 72.7591334216986 a376 gain_cnaBRCA16 1133 JNJ-26854165 MDM2 15 28 2.30258509299405 NA 3.37331071419485 2.75212206655448 0.621188647640368 0.876352480826442 0.79843148468848 0.752166694959909 0.708834243333866 0.778011212674978 0.0236267675676299 NA NA NA 0.0306130792645316 72.7591334216986 a377 loss_cnaBRCA33 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 6 42 0.246860077931526 2.32630161961136 -1.67160124968306 -0.0640019601748504 -1.60759928950821 1.07058684644999 1.62573964384458 1.02075952658029 1.5016056799492 0.988841783858166 0.0237428364450202 NA NA NA 0.0114535196215782 72.7905973710608 a378 gain_cnaBRCA15 1268 XAV 939 TNKS1 (tankyrase-1) 22 25 1.6094379124341 NA 3.98646400874682 3.37542392154594 0.611040087200884 0.952349002514946 0.839204783748481 0.68365092617692 0.64161361600344 0.72811797434179 0.0238547361793805 NA NA NA 0.0252709085974996 72.7905973710608 a379 gain_cnaBRCA61_(NOTCH2) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 3 45 2.77258872223978 NA 1.3153650661265 -0.553320019382779 1.86868508550928 1.26593686633582 1.34450276798784 1.3933114968239 1.47612818237775 1.38987076114832 0.023867620679854 NA NA NA 0.115654161182927 72.7905973710608 a380 gain_cnaBRCA30_(CRNKL1,FOXA2) 166 FTI-277 Farnesyl transferase (FNTA) 5 42 0.0237165266173161 NA 3.0110275009662 2.15312129888616 0.857906202080037 1.03078986067236 0.746057144850441 1.10610363120641 0.832280404388576 1.14992022796326 0.0238884420079481 NA NA NA 0.137101160835835 72.7905973710608 a381 gain_cnaBRCA30_(CRNKL1,FOXA2) 178 BAY 61-3606 SYK 5 43 2.07944154167984 NA 4.60732868199374 2.91998818673787 1.68734049525588 1.16251323918843 1.56123857021468 1.10233586137409 1.45145916482968 1.08077043921856 0.0240769221676152 NA NA NA 0.0264763137016956 73.1723574222615 a382 loss_cnaBRCA18 140 Vinorelbine Microtubules 15 32 -2.74887219562247 NA -4.37832156623981 -3.23489315455177 -1.14342841168804 0.873734686480268 1.79440272625596 0.729669283601087 1.30866775622037 0.637219502042227 0.0242446567392993 NA NA NA 0.0052066938020008 73.3339404909906 a383 gain_cnaBRCA30_(CRNKL1,FOXA2) 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 3 23 2.30258509299405 NA 5.86666712177449 4.53176455133794 1.33490257043655 0.805253806427191 0.912786682810108 1.47614919326181 1.65774139753445 1.46244746508233 0.0242567572398734 NA NA NA 0.0848988679629792 73.3339404909906 a384 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 7 41 2.77258872223978 NA 0.654810110998137 -0.622853084166646 1.27766319516478 1.25304794746535 1.35446806972929 0.952290198047267 1.01964429832811 0.943295175219702 0.0243312328994289 NA NA NA 0.037192687673039 73.3675379537727 a385 gain_cnaBRCA13_(FGFR1,WHSC1L1) 299 OSI-027 MTORC1/2 11 37 2.99573227355399 NA 0.104035374066658 1.61530134971697 -1.51126597565032 1.45553593007264 1.99611058109841 0.798859105874693 1.03828833382004 0.757105337730688 0.0244688887189742 NA NA NA 0.0113749717850634 73.5909772667538 a386 CDH1_mut 345 KIN001-270 CDK9 4 45 2.99573227355399 NA 4.37457736223173 5.17274339937176 -0.798166037140034 0.519395075524865 0.6670946806139 1.21180765974323 1.53672238099959 1.19648088994731 0.024581717699556 NA NA NA 0.0463021315530868 73.6659888667753 a387 MLL3_mut 152 CP466722 ATM 3 46 2.77258872223978 NA 1.41475939523507 2.81592756711912 -1.40116817188405 0.176802791725107 1.03429977431318 1.38358129952385 7.92503420456493 1.35470219242239 0.0246210706377425 NA NA NA 6.58404759133114e-07 73.6659888667753 a388 loss_cnaBRCA57 294 MPS-1-IN-1 MPS1 5 44 2.99573227355399 NA 5.85656930040335 4.63151183960769 1.22505746079566 0.396632299061701 1.16334670489201 1.09503139417455 3.0886477568613 1.05304588532735 0.0247171424113556 NA NA NA 0.000213010118376558 73.7096870238489 a389 gain_cnaBRCA30_(CRNKL1,FOXA2) 136 Mitomycin C DNA crosslinker 5 43 2.77258872223978 NA 1.25054129816284 -0.295333958260999 1.54587525642384 1.17972793063586 1.42953267637585 1.0967006207341 1.31036590410352 1.08138504419706 0.0247692146457152 NA NA NA 0.0386567991642759 73.7096870238489 a390 CDH1_mut 275 I-BET BRD2, BRD3, BRD4 4 45 2.99573227355399 NA 2.59789269873618 4.16703424694028 -1.5691415482041 1.72925197148052 1.26237394008877 1.209632751303 0.907410587978489 1.24300850831392 0.0248266499173513 NA NA NA 0.166121998303053 73.7096870238489 a391 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 235 QL-XII-47 BTK, BMX 7 42 2.32630161961136 NA 0.545443412299833 1.90184704190742 -1.35640362960759 1.10768341404999 1.47766747126657 0.94473254643778 1.22454088632438 0.917935635711708 0.0250819123129437 NA NA NA 0.0174588687473637 74.2771004275128 a392 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 135 Gemcitabine DNA replication 7 40 0.0237165266173161 NA 1.84902302887399 -0.646966912491216 2.4959899413652 1.33157480324283 2.77917826013338 0.94812082950314 1.8744646829353 0.898103578733886 0.0252811423717374 NA NA NA 0.00162993541365001 74.5695830382882 a393 loss_cnaBRCA33 254 AC220 FLT3 6 42 0.0237165266173161 NA 1.48020977908865 2.32998362836047 -0.849773849271811 1.49886883713335 0.722616169009331 1.00877128710381 0.566943436423055 1.17596849574624 0.0253439248497442 NA NA NA 0.226625179991407 74.5695830382882 a394 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 341 EX-527 SIRT1 6 43 2.99573227355399 NA 5.09016316205205 5.71871929601175 -0.628556133959691 0.703600535711207 0.614926309096973 1.00575728227542 0.893342318627344 1.02216497271475 0.0254582363515142 NA NA NA 0.081842212563571 74.5695830382882 a395 gain_cnaBRCA16 1175 AG-014699 PARP1, PARP2 15 28 1.6094379124341 NA 4.33171877857502 3.60970557889831 0.722013199676715 0.912381875909834 1.00351663508441 0.741776117795773 0.791349783177924 0.719483040374293 0.0255003551500561 NA NA NA 0.0232029590896681 74.5695830382882 a396 ASH1L_mut 1025 SB 216763 GSK3A, GSK3B 3 36 2.30258509299405 NA 3.93169216922981 4.9689504302456 -1.0372582610158 0.79748745711094 0.738396138857938 1.39846756321247 1.30065777432221 1.40474496876446 0.0255344762460698 NA NA NA 0.144905454087154 74.5695830382882 a397 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 155 AP-24534 ABL 14 33 -0.669430653942629 NA 2.00443677949179 1.20817557121431 0.796261208277486 0.711232973308748 1.19944635511678 0.736398556553 1.11955046821462 0.663857291224965 0.0256037964001146 NA NA NA 0.00745276279018687 74.5695830382882 a398 loss_cnaBRCA36_(FAT1,IRF2) 156 AZD6482 PI3Kbeta 9 38 1.63315443905142 NA 3.01688021584634 1.8250957565511 1.19178445929524 1.14924671978878 1.44032696935153 0.855532854097485 1.03701358357088 0.827440216461272 0.0256630167581565 NA NA NA 0.018274862964579 74.5695830382882 a399 TP53_mut 52 GNF-2 ABL [T315I] 9 3 0.246860077931526 NA 2.68362009174435 1.89649091110991 0.787129180634432 0.422665981402111 0.55005099133488 1.74517978695191 1.86229603343824 1.43101129356063 0.0256958836102228 NA NA NA 0.113428812172351 74.5695830382882 a400 gain_cnaBRCA16 1264 SGC0946 Q8TEK3 (DOT1L) 16 30 -0.693147180559945 NA 2.21984793962335 1.80717538262658 0.412672556996768 0.516416090377552 0.607145826703636 0.714191268228371 0.79910863485114 0.679692651825152 0.025818495671223 NA NA NA 0.0205467947984827 74.7380903442728 a401 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 281 CH5424802 ALK 9 39 1.63315443905142 NA 4.27811919496314 3.4130366486052 0.865082546357939 0.340409602395087 1.10700311446774 0.85136437841085 2.54129889483524 0.781463516273736 0.0258987283996577 NA NA NA 0.000179290378968116 74.7833855709817 a402 ASH1L_mut 165 DMOG Prolyl-4-Hydroxylase 3 43 8.29404964010203 NA 5.69113088472933 7.70106311461216 -2.00993222988283 1.17332311225486 1.47400011980054 1.37508793437358 1.71302534561022 1.36359027579645 0.0260808428012994 NA NA NA 0.0840302487055177 75.1219101483198 a403 gain_cnaBRCA27_(CLTC,PPM1D) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 9 39 2.07944154167984 NA 2.45089233860026 3.39047524594304 -0.939582907342772 1.05772666964703 1.11862881650186 0.847786630693793 0.888304071652381 0.839941626285839 0.0264966668563858 NA NA NA 0.0342822721142029 75.7729786191176 a404 ASH1L_mut 153 Midostaurin KIT 3 44 -0.669430653942629 NA -1.16613008708552 0.733432756706966 -1.89956284379249 1.02961496868386 1.40239147346318 1.36860917161115 1.84492543481634 1.35451682339565 0.0265369048386547 NA NA NA 0.0707551849605243 75.7729786191176 a405 gain_cnaBRCA30_(CRNKL1,FOXA2) 134 Etoposide TOP2 5 42 2.77258872223978 NA 4.47272278751015 2.2395277575608 2.23319502994935 1.02046000928442 2.1332904184161 1.08466783688869 2.18841993770568 1.04683122873041 0.026589669485537 NA NA NA 0.0032556811304757 75.7729786191176 a406 POLR2B_mut 293 MP470 PDGFR 3 45 2.99573227355399 NA 1.49096066377192 3.66762680958469 -2.17666614581277 1.818250796427 1.58290794335158 1.36565448927517 1.19712096378018 1.37510595922842 0.02663944931914 NA NA NA 0.168320126144673 75.7729786191176 a407 NF1_mut 1007 Docetaxel Microtubules 4 41 -4.38202663467388 NA -2.97837366362486 -4.74424609376152 1.76587243013666 1.59972195565976 1.45823912937646 1.20245789136112 1.10386209546544 1.21096217661622 0.0266413481380029 NA NA NA 0.11069526067727 75.7729786191176 a408 gain_cnaBRCA63 167 OSU-03012 PDPK1 (PDK1) 6 42 2.77258872223978 NA 3.23621537300277 2.10680240681024 1.12941296619253 1.63251846351288 1.05289319408516 0.999139249272879 0.69182247639775 1.07267572108665 0.0266995209228776 NA NA NA 0.154216405373011 75.7729786191176 a409 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1030 KU-55933 ATM 15 27 2.30258509299405 NA 4.63852802176894 3.99106120686952 0.647466814899416 0.823983010165142 0.900284315145331 0.740523512360971 0.785776899416472 0.719180378917184 0.0267732525390986 NA NA NA 0.0246945054317978 75.7964526039664 a410 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1053 MK-2206 AKT1, AKT2 14 28 1.38629436111989 0.693147180559945 0.611879177887715 1.78487899032342 -1.17299981243571 1.14487224049336 1.72375176602872 0.752227614444183 1.0245683063555 0.680492304955335 0.0268636256740859 NA NA NA 0.0125848598307274 75.8668101659124 a411 MLL3_mut 258 STF-62247 stimulates autophagy 3 46 2.32630161961136 NA 3.45808305261904 4.70732724360579 -1.24924419098675 0.977347797739884 0.916227896010816 1.3594825044325 1.27819819502906 1.36346447911689 0.0270946490268543 NA NA NA 0.15062336662533 76.3330756890379 a412 gain_cnaBRCA47_(EGFR) 197 Bryostatin 1 PRKC 7 41 -4.8283137373023 NA -3.54173784778507 -2.68132739936224 -0.860410448422829 0.88892198912967 0.928026121815719 0.93216926919643 0.967925711079826 0.927140333872719 0.0273311848984317 NA NA NA 0.0451348322232896 76.8125703735293 a413 gain_cnaBRCA31 231 FMK RSK 16 33 2.99573227355399 2.32630161961136 5.85406005277593 5.46082710080584 0.393232951970098 0.585178910167205 0.55885576084641 0.69305649421675 0.671987566772934 0.703639435289225 0.0275083271137667 NA NA NA 0.0331679454612306 76.9007068249333 a414 loss_cnaBRCA57 269 NSC-207895 MDM4 5 44 2.99573227355399 NA 5.69862895779027 4.4795461996887 1.21908275810157 0.568109870192009 1.17484788818788 1.07323188812635 2.14585738087871 1.03765157205322 0.02756959080924 NA NA NA 0.00370858182409321 76.9007068249333 a415 gain_cnaBRCA62 71 Pyrimethamine Dihydrofolate reductase (DHFR) 5 9 2.99573227355399 NA 3.81696930843997 4.98766036154654 -1.17069105310657 1.32786235555557 0.413616152858096 1.397456144846 0.881635847426945 2.83038040225719 0.0276391989843432 NA NA NA 0.120196127999124 76.9007068249333 a416 gain_cnaBRCA48 1005 Cisplatin DNA crosslinker 5 40 1.79175946922805 2.30258509299405 2.58769261696305 3.80538241841404 -1.21768980145099 0.832835732672983 1.152000200707 1.08130206718792 1.46210081253696 1.05702221293336 0.0276533254833804 NA NA NA 0.0255203883908633 76.9007068249333 a417 gain_cnaBRCA14_(RAD21) 83 JW-7-52-1 MTOR 6 6 0.182321556793955 NA -3.32354881366721 -0.716281829319866 -2.60726698434734 1.65063448273226 1.8522854965112 1.48616444949458 1.57955441475546 1.40759455778181 0.0276946150323838 NA NA NA 0.0279633370645832 76.9007068249333 a418 loss_cnaBRCA18 261 TL-1-85 MAP3K7 (TAK1) 16 33 2.32630161961136 NA 3.48541056843923 4.28633174958075 -0.800921181141525 1.07665277478458 1.19585715687377 0.690958076694401 0.743899240218623 0.669746529957897 0.0279570396598893 NA NA NA 0.0247276523050721 77.3694998313411 a419 POLR2B_mut 1248 FK866 NAMPT 3 41 0 NA -3.9259267036278 -0.411055565493303 -3.5148711381345 2.18403864935869 2.60013435034161 1.36138154524004 1.6093447518278 1.35180366263486 0.0279970812931444 NA NA NA 0.0956974943249091 77.3694998313411 a420 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 89 Parthenolide NFKB1 5 9 1.6094379124341 NA 4.30165976850211 2.66553556819944 1.63612420030267 0.252050922346395 1.42850318614534 1.39195935314248 6.49124464640576 1.14534165283704 0.0281434518161409 NA NA NA 0.00879341612520082 77.5888163283561 a421 gain_cnaBRCA31 1032 Afatinib ERBB2, EGFR 14 31 -0.693147180559945 NA -0.587024614410688 0.68676035579132 -1.27378497020201 2.44432638435896 1.33316064555003 0.729809600590268 0.521119020091937 0.955462475174158 0.0285111329121542 NA NA NA 0.085152098891417 78.4157738693191 a422 gain_cnaBRCA47_(EGFR) 263 FR-180204 ERK 7 42 2.99573227355399 NA 4.80350962583797 5.45028076662502 -0.646771140787052 0.995880365606534 0.647288831087646 0.921979974623396 0.64944662343367 0.999200217467489 0.0286042015330279 NA NA NA 0.14152366798489 78.4853197987986 a423 loss_cnaBRCA33 1371 PLX4720 (rescreen) BRAF 5 42 2.30258509299405 NA 3.8342926329839 4.81105861887278 -0.976765985888879 2.20625239461915 0.663868547883774 1.06942648395283 0.44272631194469 1.47132438944808 0.0286729246294584 NA NA NA 0.379430158593794 78.4878946299052 a424 loss_cnaBRCA57 295 NVP-BHG712 EPHB4 5 44 2.32630161961136 NA 5.0105889471157 3.75899453698847 1.25159441012723 0.494932047583772 1.22029556444076 1.06418131466837 2.52882070627157 1.02564857776961 0.0288375261873312 NA NA NA 0.00117046159926749 78.7522914441292 a425 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 255 CP724714 ERBB2 7 41 2.32630161961136 NA 2.54650138175738 4.01756593215216 -1.47106455039479 1.75736704297156 1.56965805510679 0.922069290643526 0.837084407766823 0.937187908926252 0.0289579078085386 NA NA NA 0.0726072425225115 78.8949681211926 a426 ASH1L_mut 134 Etoposide TOP2 3 44 2.77258872223978 NA -0.119182549438542 2.65412107735045 -2.773303626789 0.812728707911646 2.10268128358467 1.34459756081144 3.41233624429874 1.31893675396256 0.029156438005113 NA NA NA 0.00710288071598438 79.0939862770081 a427 gain_cnaBRCA30_(CRNKL1,FOXA2) 229 LY317615 PRKCB (PKCbeta) 5 44 2.99573227355399 2.32630161961136 1.8858623131425 3.52593770369463 -1.64007539055213 0.779804173234898 1.59747618068679 1.06165481932715 2.10318878360003 1.02666656966805 0.0292006046387042 NA NA NA 0.00418269267417201 79.0939862770081 a428 PIK3CA_mut 1011 ABT-263 BCL2, BCL2L1, BCL2L2 15 28 0.693147180559945 NA 2.4298544211391 1.28128234335074 1.14857207778837 0.938274781862367 1.83835274051298 0.722649437381133 1.2241318854468 0.624783292388091 0.0293004901248877 NA NA NA 0.00973566325271758 79.0939862770081 a429 gain_cnaBRCA63 173 FH535 unknown 6 42 3.46573590279973 NA 2.6247364942751 1.42274972390043 1.20198677037467 2.15068696693974 1.05714315401214 0.981796012236914 0.558885039455555 1.13701419321764 0.0293041887147737 NA NA NA 0.232537892864436 79.0939862770081 a430 gain_cnaBRCA30_(CRNKL1,FOXA2) 202 GSK-1904529A IGF1R 5 43 0.0237165266173161 NA 2.94694477064505 2.10161973353725 0.845325037107794 1.03295175232883 0.770361431793687 1.06111448177677 0.818358684422555 1.09730965520894 0.0295667967613894 NA NA NA 0.142357461632619 79.6171952790995 a431 gain_cnaBRCA61_(NOTCH2) 176 IPA-3 PAK1, PAK2, PAK3 3 44 3.46573590279973 NA 6.30342185778652 4.37366337674574 1.92975848104078 0.328221499756558 1.47419835039559 1.33757760355348 5.87943959329929 1.30902227676686 0.0299645528450879 NA NA NA 5.06458812342594e-05 80.5010573998313 a432 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1072 BMS-708163 g-secretase 8 38 1.6094379124341 NA 4.34049083163012 3.54609375570792 0.794397075922199 0.836650069093645 0.92548985296253 0.871111176261059 0.949497412679092 0.858353090938061 0.0302335820848363 NA NA NA 0.0356851638016651 80.6218558481969 a433 gain_cnaBRCA15 1375 Temozolomide DNA akylating agent 21 25 3.40119738166216 NA 6.14015237089556 5.69850372961416 0.441648641281404 0.696922363156333 0.640356307001209 0.662476199725911 0.63371282746789 0.689692029972573 0.0303276208517545 NA NA NA 0.0318880892797273 80.6218558481969 a434 loss_cnaBRCA38 165 DMOG Prolyl-4-Hydroxylase 4 42 8.29404964010203 NA 6.00322052666249 7.71919582085383 -1.71597529419135 1.24772890979993 1.48085583600738 1.17040436073034 1.37527894137397 1.15877268567742 0.0304214695793767 NA NA NA 0.0634428276097997 80.6218558481969 a435 PIK3CA_mut 176 IPA-3 PAK1, PAK2, PAK3 16 31 3.46573590279973 NA 3.84304746552771 4.83428047424931 -0.991233008721597 1.87708516406221 1.16767263428455 0.6867261852263 0.52807034422267 0.848896325577539 0.0307180357325386 NA NA NA 0.0673172505195387 80.6218558481969 a436 gain_cnaBRCA48 286 KIN001-236 TIE2 5 44 2.32630161961136 NA 5.23383886026087 4.46127048307359 0.772568377187278 0.25553393306443 0.764362579573994 1.05125065859599 3.02334945469839 1.01073547794276 0.0307389001322124 NA NA NA 0.000260064808431877 80.6218558481969 a437 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 133 Doxorubicin DNA intercalating 7 41 0.0237165266173161 NA 0.3369226061232 -1.2641321329876 1.6010547391108 1.12680405854909 1.83254560595479 0.9114270106356 1.42088123215706 0.873677977731214 0.0307645641280128 NA NA NA 0.00864228289610223 80.6218558481969 a438 TP53_mut 1373 Dabrafenib BRAF 36 10 2.30258509299405 NA 4.48527744549771 3.24011120126926 1.24516624422844 1.00676891322718 2.82646724882273 0.797077794077878 1.23679448964816 0.44053800543667 0.030909052477193 NA NA NA 0.201985239233207 80.6218558481969 a439 loss_cnaBRCA33 271 VNLG/124 HDAC, RAR 6 43 1.63315443905142 NA 3.48835323413137 4.24396385514221 -0.755610621010846 0.644352745334743 0.793752460045986 0.969699262612805 1.17266610017826 0.951947438332436 0.0309115569034513 NA NA NA 0.0336754692626791 80.6218558481969 a440 gain_cnaBRCA16 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 14 29 -1.38629436111989 0.693147180559945 -1.77566141936189 -2.43526619266087 0.659604773298979 1.03849197622105 0.83880744378856 0.727322157591832 0.635156350171528 0.786360180972889 0.0309350281316801 NA NA NA 0.0504316050301551 80.6218558481969 a441 gain_cnaBRCA30_(CRNKL1,FOXA2) 1371 PLX4720 (rescreen) BRAF 5 42 2.30258509299405 NA 5.56848133446289 4.60460758298243 0.963873751480464 0.832028687267593 0.922383958055288 1.05374345429381 1.15846216149813 1.04498104402493 0.0309669772355176 NA NA NA 0.0578257645046173 80.6218558481969 a442 gain_cnaBRCA31 35 NVP-TAE684 ALK 4 10 0.693147180559945 NA 2.83077719112622 1.3499395834695 1.48083760765673 0.666034241485037 1.11956605605789 1.44448142676017 2.22336558005628 1.32268891115806 0.031065723666601 NA NA NA 0.0129706565533621 80.6218558481969 a443 gain_cnaBRCA62 1054 PD-0332991 CDK4, CDK6 7 35 1.38629436111989 0.693147180559945 3.95766645639863 2.66795239469914 1.28971406169949 0.953905951333933 1.45779512070558 0.92527368454189 1.3520348205145 0.884701864741638 0.0310861444841816 NA NA NA 0.011670937680234 80.6218558481969 a444 gain_cnaBRCA30_(CRNKL1,FOXA2) 1050 ZM-447439 AURKB 4 35 1.38629436111989 0.693147180559945 4.21229656859169 2.73656722589821 1.47572934269349 1.51840768031323 1.22067366458568 1.18298319945486 0.97189270169462 1.20894665421849 0.0310878061516979 NA NA NA 0.145053475399796 80.6218558481969 a445 loss_cnaBRCA18 303 PIK-93 PI4K, PI3K 16 33 2.99573227355399 NA 2.17029527843531 3.09273055541657 -0.922435276981257 1.182704200743 1.43934154144224 0.676918678924641 0.779937431863155 0.640873100943759 0.0311301965862426 NA NA NA 0.0227793975095214 80.6218558481969 a446 gain_cnaBRCA31 1248 FK866 NAMPT 14 30 0 NA 0.622466683397318 -1.24485306212238 1.86731974551969 1.99593909106101 2.81272356760531 0.721639330239364 0.935559483694995 0.663883136980108 0.0311802400279862 NA NA NA 0.0163992073041367 80.6218558481969 a447 gain_cnaBRCA16 1017 Olaparib PARP1, PARP2 15 30 1.6094379124341 NA 4.47270047468448 3.87479690938445 0.597903565300033 0.909342516768673 0.818315137562294 0.704224480571534 0.657511943271573 0.730651967506244 0.031238238589725 NA NA NA 0.0413164131609468 80.6218558481969 a448 loss_cnaBRCA36_(FAT1,IRF2) 223 ZSTK474 PI3K 9 40 1.63315443905142 2.32630161961136 1.83932218449253 0.703766511121531 1.135555673371 1.60570283648136 1.33847818229744 0.818358184052786 0.707201636299897 0.848393114202185 0.0314112976256172 NA NA NA 0.0750275474957277 80.6218558481969 a449 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1494 SN-38 TOP1 15 33 -2.99573227355399 NA -2.53769687706424 -3.65201197940511 1.11431510234087 2.03215337287695 1.38901718461024 0.691199333411123 0.548342028320098 0.802232769102528 0.0314121097916338 NA NA NA 0.0679452959901681 80.6218558481969 a450 gain_cnaBRCA47_(EGFR) 1192 GSK269962A ROCK1, ROCK2 7 39 1.6094379124341 NA 3.74988269650519 2.47374944814338 1.27613324836181 1.02636193706651 1.44892623082887 0.91227921277935 1.2433559763617 0.880744113267785 0.0314406467229817 NA NA NA 0.0167876997572943 80.6218558481969 a451 gain_cnaBRCA16 229 LY317615 PRKCB (PKCbeta) 16 33 2.99573227355399 2.32630161961136 2.6547402767603 3.69984018485187 -1.04509990809156 1.44062186417796 1.59434540778203 0.675589455985621 0.725450539158595 0.655504072699938 0.0314465613929791 NA NA NA 0.0280661637489649 80.6218558481969 a452 gain_cnaBRCA30_(CRNKL1,FOXA2) 271 VNLG/124 HDAC, RAR 5 44 1.63315443905142 NA 4.88366467097021 4.06823276866028 0.815431902309934 0.866444653803843 0.770920141007641 1.04608836591959 0.941124050716968 1.05773848539501 0.0315284954260331 NA NA NA 0.102922319187732 80.6218558481969 a453 BRCA2_mut 170 Shikonin unknown 6 41 2.77258872223978 NA -0.957192852294795 0.144213010926127 -1.10140586322092 1.44539693807151 1.09039763290935 0.970113709477202 0.762009268326282 1.01009561097652 0.0315413254160404 NA NA NA 0.124237640708105 80.6218558481969 a454 loss_cnaBRCA17 306 TG101348 JAK2 10 38 2.32630161961136 NA 2.45850548590117 3.42656878580343 -0.968063299902255 0.960627281245661 1.28574672608695 0.78773299645987 1.00774079479291 0.752919124941867 0.0316484768993426 NA NA NA 0.0168444208532709 80.6554021334237 a455 loss_cnaBRCA38 190 Bleomycin DNA damage 4 44 4.15888308335967 NA -0.70525749572881 2.33145885197108 -3.03671634769989 1.07242825127817 2.70336403165008 1.1555087068859 2.83162658581644 1.12331018395859 0.0319259219531372 NA NA NA 0.00249459901188045 80.6554021334237 a456 PTEN_mut 1502 Bicalutamide ANDR (androgen receptor) 8 37 2.30258509299405 NA 4.1623436140637 4.64391600189711 -0.481572387833414 0.301888823316437 0.594315513651823 0.864166471967933 1.59519780342658 0.810297521722681 0.0320090459264363 NA NA NA 0.00322292913534535 80.6554021334237 a457 gain_cnaBRCA62 179 5-Fluorouracil DNA antimetabolite 10 39 3.46573590279973 NA 3.07418193298596 4.28950098422523 -1.21531905123927 1.31493405217857 1.60261233492567 0.783238359121627 0.924243348345681 0.758336264331599 0.0320355454612381 NA NA NA 0.0238457946647615 80.6554021334237 a458 loss_cnaBRCA33 38 AZD-0530 SRC, ABL1 5 9 0.693147180559945 NA 3.06615165380578 2.31999794562009 0.746153708185695 0.354507825723246 0.627716952313875 1.35200808153406 2.10475948355565 1.18867860017997 0.0320858649539775 NA NA NA 0.0148904871711388 80.6554021334237 a459 gain_cnaBRCA62 292 Masitinib KIT 10 38 2.99573227355399 NA 3.36140548749707 4.18109630083601 -0.819690813338937 0.962650560180116 1.06259259230659 0.78530094274668 0.851493623174716 0.771406481913843 0.0321523319048661 NA NA NA 0.0330109893744001 80.6554021334237 a460 gain_cnaBRCA16 1194 SB-505124 TGFR1 (ALK5) 16 31 2.30258509299405 NA 4.78342154036136 4.18542621124952 0.597995329111832 0.856813519538994 0.889435418618958 0.68054857340681 0.697929380752047 0.672331365036429 0.03217419469665 NA NA NA 0.0324409087024443 80.6554021334237 a461 gain_cnaBRCA30_(CRNKL1,FOXA2) 1170 CCT018159 HSP90 4 39 2.30258509299405 NA 4.54134218062331 3.21990392098831 1.32143825963501 1.63197424571078 1.08641243619301 1.16399956535242 0.80971759395595 1.21633204445411 0.032221616912244 NA NA NA 0.203709967785863 80.6554021334237 a462 loss_cnaBRCA33 1061 SB590885 BRAF 5 37 1.6094379124341 NA 3.04822669350723 4.14213939951042 -1.09391270600319 2.00080850811714 0.864220360754115 1.05628584932684 0.546735333024255 1.26577983542143 0.0323794316440372 NA NA NA 0.29078480896642 80.6554021334237 a463 loss_cnaBRCA29_(MAP2K4) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 5 38 0.693147180559945 NA 0.199144871834379 1.87705256767724 -1.67790769584287 2.22874868563042 1.5080747554635 1.05343018649796 0.752847419119511 1.11261573059564 0.0324220246753366 NA NA NA 0.169525932431526 80.6554021334237 a464 ARID1A_mut 268 YM155 BIRC5 (Survivin) 5 44 1.63315443905142 NA -2.16416271992188 -3.75823882948305 1.59407610956117 1.39784632711672 1.54487660697056 1.03990024543997 1.14038008230075 1.03184688173063 0.032498614806505 NA NA NA 0.0606851918858453 80.6554021334237 a465 loss_cnaBRCA33 300 CX-5461 RNA Pol I 6 43 2.32630161961136 NA 2.53209347258796 4.10496136121941 -1.57286788863145 2.29903580260752 1.54072984718191 0.960136325090437 0.684142407372491 1.02085897245927 0.0325215480224694 NA NA NA 0.15826409283287 80.6554021334237 a466 CDH1_mut 276 CAY10603 HDAC6 4 45 2.99573227355399 NA 0.171492880297755 1.26478835562357 -1.09329547532582 0.907224013842492 0.954183370340706 1.14931875460238 1.20509979745271 1.14579179359984 0.0325466783100193 NA NA NA 0.0899741890045714 80.6554021334237 a467 loss_cnaBRCA18 273 CUDC-101 HDAC, EGFR 16 33 1.63315443905142 NA -0.706431715222482 0.302943345155125 -1.00937506037761 0.944533537238886 1.70490407958203 0.670869199975077 1.0686492544545 0.592042140356109 0.0325931348167053 NA NA NA 0.0106805816659805 80.6554021334237 a468 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1025 SB 216763 GSK3A, GSK3B 5 34 2.30258509299405 NA 5.58001673982529 4.78756494992367 0.792451789901623 0.843335882311105 0.733447675424408 1.06211383294326 0.939663313898091 1.08044761263041 0.0328118579469282 NA NA NA 0.103613225942044 80.6554021334237 a469 gain_cnaBRCA30_(CRNKL1,FOXA2) 279 BIX02189 MAP2K5 (MEK5) 5 44 2.99573227355399 NA 5.83148694902917 4.93597753267207 0.895509416357104 0.783089167090901 0.870502959716496 1.03717976936754 1.14355995969633 1.02872644643133 0.0329333940798622 NA NA NA 0.0601706470151488 80.6554021334237 a470 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 186 Bexarotene Retinioic acid X family agonist 7 40 2.07944154167984 NA 4.44211737160183 3.45780587808878 0.984311493513051 1.18826701262831 1.07610463961911 0.901610691460058 0.828358847845036 0.914698680103687 0.0329350142689185 NA NA NA 0.0753709339023101 80.6554021334237 a471 gain_cnaBRCA30_(CRNKL1,FOXA2) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 4 39 0.693147180559945 NA 3.86573572960489 2.81023233084026 1.05550339876464 1.01996762895831 0.90222770806536 1.15816455091961 1.03484009570246 1.16988581632895 0.0330483929890688 NA NA NA 0.127328092739825 80.6554021334237 a472 gain_cnaBRCA27_(CLTC,PPM1D) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 10 36 2.30258509299405 NA 1.99923211466557 1.25038124879072 0.748850865874858 0.932633106599552 0.956953266581193 0.786583899332989 0.802942615457028 0.782536506249881 0.0330672293470936 NA NA NA 0.0414990576570174 80.6554021334237 a473 gain_cnaBRCA30_(CRNKL1,FOXA2) 346 THZ-2-102-1 CDK7 5 43 0.916290731874155 2.99573227355399 0.933204486252743 -1.59892067646154 2.53212516271428 2.61017913903217 2.42216343765663 1.03814422628657 0.970096314405902 1.04539814421608 0.0330861184825312 NA NA NA 0.0953581896410125 80.6554021334237 a474 MLL3_mut 211 TL-2-105 CRAF 3 46 2.32630161961136 1.63315443905142 2.62514582065771 3.99118903538024 -1.36604321472253 2.34116726703046 0.946101316268673 1.30827920338673 0.583488089022883 1.44386567403802 0.0330969901360744 NA NA NA 0.418715953312085 80.6554021334237 a475 gain_cnaBRCA16 1004 Vinblastine Microtubules 15 30 -2.30258509299405 NA -2.88633961956252 -3.74017072369416 0.853831104131646 1.06945042156114 1.29544293060481 0.696184079562735 0.798383063784532 0.659103603840747 0.0331136090642269 NA NA NA 0.0249185665167226 80.6554021334237 a476 loss_cnaBRCA57 263 FR-180204 ERK 5 44 2.99573227355399 NA 6.01195789903573 5.28355841099859 0.728399488037147 0.369981654309377 0.726718681484789 1.03548650998957 1.9687448811396 1.00231287098458 0.0332065938570476 NA NA NA 0.00613004349945482 80.6554021334237 a477 gain_cnaBRCA10_(MDM2,NUP107) 1069 EHT 1864 Rac GTPases 3 43 2.30258509299405 NA 4.56968189619828 3.49107795761137 1.07860393858691 0.734980754934584 0.825525171673202 1.31276751472791 1.46752677719148 1.30656698983601 0.0332262084961077 NA NA NA 0.115577633124955 80.6554021334237 a478 loss_cnaBRCA18 156 AZD6482 PI3Kbeta 15 32 1.63315443905142 NA 1.39846695014619 2.36026738873019 -0.961800438584 1.22819179529378 1.47116051250751 0.686953263786669 0.783102803869441 0.65376988466382 0.0333390654656431 NA NA NA 0.0252766607685682 80.7600500055819 a479 gain_cnaBRCA27_(CLTC,PPM1D) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 10 36 1.38629436111989 NA 3.7285076242389 2.61697080500516 1.11153681923374 0.958123415319242 1.51331495418831 0.78412278382517 1.16011862507648 0.734504615947536 0.033592302262504 NA NA NA 0.00973294879107167 81.2036049890467 a480 gain_cnaBRCA58_(CCND1) 309 Y-39983 ROCK 10 39 2.99573227355399 NA 5.57678340503917 4.770416189358 0.806367215681168 0.588822366904372 1.12026263893722 0.775545613498224 1.36945751555006 0.719801935415927 0.0336784216147433 NA NA NA 0.00420052172739488 81.2421758077318 a481 loss_cnaBRCA57 203 BMS-345541 IKBKB 5 44 2.77258872223978 NA 4.42786869425409 3.43056662852642 0.997302065727668 0.963945901798035 0.96814078444471 1.03050016327328 1.03460377171314 1.03012090984235 0.0340227781784481 NA NA NA 0.0803684337760185 81.6702553482754 a482 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 211 TL-2-105 CRAF 15 34 2.32630161961136 1.63315443905142 3.41715695468568 4.12390525791703 -0.706748303231358 1.28392648906403 0.924745684234229 0.676489044431387 0.550458542020244 0.764262342912806 0.0341066809483843 NA NA NA 0.0683353039521608 81.6702553482754 a483 gain_cnaBRCA30_(CRNKL1,FOXA2) 1378 Bleomycin (50 uM) DNA damage 5 43 3.91202300542815 NA 5.4833799235633 3.61845455382266 1.86492536974064 1.34368036915435 1.84722896339495 1.03090656495333 1.38792335778064 1.00957997448955 0.0342692945595368 NA NA NA 0.031178810243413 81.6702553482754 a484 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 14 32 2.30258509299405 NA 1.87681403352764 1.2103328010542 0.666481232473441 0.883279722427329 0.980454877028723 0.699515030530211 0.75455285064384 0.679767369298236 0.0344133631284537 NA NA NA 0.0308734271492899 81.6702553482754 a485 loss_cnaBRCA57 276 CAY10603 HDAC6 5 44 2.99573227355399 NA 2.05437926319109 1.07567161837037 0.978707644820715 1.08118954884517 0.939371727983278 1.02776930081369 0.905213748936143 1.04187470802628 0.0344772354659437 NA NA NA 0.113224018189677 81.6702553482754 a486 BRCA2_mut 157 JNK-9L JNK 6 41 1.63315443905142 NA -0.784664978195061 0.178845655292513 -0.963510633487574 0.537107246303356 1.05637353436821 0.952158511460803 1.79388872542484 0.912092741952144 0.03465885806801 NA NA NA 0.00440225687825262 81.6702553482754 a487 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 292 Masitinib KIT 14 34 2.99573227355399 NA 3.49853489240857 4.2210654650888 -0.722530572680229 1.01059054602514 1.05862142118516 0.691237403903907 0.714958768931778 0.682520264771646 0.0346680465259175 NA NA NA 0.0355660366092632 81.6702553482754 a488 gain_cnaBRCA63 224 AS605240 PI3Kgamma 7 42 2.99573227355399 2.32630161961136 2.11523237759252 3.46276081127908 -1.34752843368656 2.91322874966316 1.1828693010852 0.887763199848505 0.462554968895721 1.13920314987488 0.0347298752081796 NA NA NA 0.270451382365858 81.6702553482754 a489 gain_cnaBRCA63 1007 Docetaxel Microtubules 6 39 -4.38202663467388 NA -3.36499506106335 -4.77532343929081 1.41032837822746 2.16265223512287 1.36084355543197 0.955106570954265 0.652129064175376 1.03636334433739 0.0349388270774449 NA NA NA 0.175176883661464 81.6702553482754 a490 loss_cnaBRCA33 1033 Vismodegib SMO 5 40 2.30258509299405 NA 4.07250003700999 4.84568388626587 -0.773183849255878 0.60647487160251 0.761617362369663 1.03291816745456 1.27488192085002 1.01518674265805 0.0349702163632242 NA NA NA 0.042262751517073 81.6702553482754 a491 gain_cnaBRCA16 1038 NU-7441 PRKDC (DNAPK) 14 29 0.693147180559945 NA 3.32461120635003 2.68443582017361 0.640175386176417 0.929112485491244 0.889065360624854 0.709763618217508 0.689018171828722 0.720054356550893 0.0349796316489137 NA NA NA 0.0417826835791726 81.6702553482754 a492 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1129 PF-4708671 RPS6KB1 (p70S6KA) 13 30 2.30258509299405 NA 3.25679900342375 4.04823968864631 -0.791440685222562 1.04359449999791 1.11281317765814 0.724094214263428 0.758379509689011 0.711207146996689 0.0349992496274384 NA NA NA 0.0346401476775563 81.6702553482754 a493 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 310 YM201636 FYV1 15 34 1.63315443905142 NA 1.95863058644956 2.61586023263027 -0.657229646180707 0.857457742302626 1.02317954215558 0.672866861558553 0.766486339508435 0.64234048776629 0.0350319637014493 NA NA NA 0.0265291558969139 81.6702553482754 a494 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 221 TAK-715 p38a 6 43 2.99573227355399 2.32630161961136 5.28472960061248 4.37016524133047 0.914564359282009 0.49522454092716 1.00836435534428 0.945962230897109 1.84676703939139 0.906978072395031 0.0350442105201042 NA NA NA 0.00365126026063085 81.6702553482754 a495 gain_cnaBRCA30_(CRNKL1,FOXA2) 1072 BMS-708163 g-secretase 5 41 1.6094379124341 NA 4.52393978685448 3.58184854721145 0.942091239643029 1.47273169099258 0.838614898908169 1.03004347016069 0.639689663368406 1.12338958068785 0.03508965157021 NA NA NA 0.22823614520579 81.6702553482754 a496 loss_cnaBRCA7_(FAS,PTEN) 298 OSI-930 KIT, VEGFR, PDGFR 4 44 2.32630161961136 NA 4.78505768326039 3.83412271582239 0.950934967437994 0.733363331477068 0.845422301460526 1.13399500187125 1.29667645847893 1.12480468730856 0.0350921324232684 NA NA NA 0.0744311100359528 81.6702553482754 a497 gain_cnaBRCA47_(EGFR) 208 SB-715992 KIF11 7 42 -2.05572501506252 NA -2.48554842115907 -1.03229109396837 -1.45325732719071 1.53049068357177 1.65600779904976 0.885852093624839 0.949536866045584 0.877566716789982 0.0351038350394811 NA NA NA 0.0487043598842336 81.6702553482754 a498 gain_cnaBRCA15 1243 piperlongumine Increases ROS levels 22 25 2.30258509299405 NA 1.9866834929006 1.46698321088301 0.519700282017586 0.987101699283244 0.634858766905558 0.635074412123518 0.52649112284474 0.818607711051578 0.0351254747071778 NA NA NA 0.0416712537781927 81.6702553482754 a499 gain_cnaBRCA47_(EGFR) 288 KIN001-055 JAK3, MNK1 7 42 2.32630161961136 NA 3.71575257262416 4.44288272579206 -0.727130153167906 1.07498765421846 0.777497971549519 0.885129256867112 0.676407910653213 0.935218071011514 0.0352461996299338 NA NA NA 0.129296829356296 81.6851111796178 a500 loss_cnaBRCA57 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 5 38 1.6094379124341 NA 4.11515582419946 2.70385410386268 1.41130172033677 0.716180528086203 1.41508851331756 1.03560965217056 1.97059493380543 0.997323988609083 0.0352999933157755 NA NA NA 0.00601306187664531 81.6851111796178 a501 gain_cnaBRCA63 207 AS601245 JNK 6 42 2.07944154167984 NA 3.28615571530753 2.12049285569949 1.16566285960804 1.83425010832971 1.13666376894767 0.946326737183073 0.635498318530568 1.02551246151465 0.0353435017713002 NA NA NA 0.184221201139194 81.6851111796178 a502 loss_cnaBRCA42 179 5-Fluorouracil DNA antimetabolite 3 46 3.46573590279973 NA 2.15798457060257 4.16431313049644 -2.00632855989387 2.17586963899163 1.52103452579566 1.29063409200745 0.922081233149457 1.31905523896268 0.0354225010511793 NA NA NA 0.249079436566047 81.7046094963357 a503 loss_cnaBRCA33 1003 Camptothecin TOP1 5 40 -2.30258509299405 NA -3.92009034146522 -2.35543033184992 -1.5646600096153 1.81927863191596 1.48623283743624 1.02918201539029 0.860044185737228 1.05276910198966 0.0356007404895073 NA NA NA 0.127750135683353 81.8309052117296 a504 gain_cnaBRCA47_(EGFR) 269 NSC-207895 MDM4 7 42 2.99573227355399 NA 3.73991264781494 4.74794735810833 -1.00803471029339 1.15036663406976 1.13994227195355 0.88325053760584 0.876272555582706 0.88428575296703 0.0356185993839811 NA NA NA 0.0634681247084704 81.8309052117296 a505 PTEN_mut 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 4 22 2.30258509299405 NA 3.74830126717066 4.85624458988243 -1.10794332271177 1.21577681887388 0.866486953067371 1.20763393764048 0.911304859174742 1.27866128715458 0.0359861458198392 NA NA NA 0.164581996663878 82.0608635609439 a506 PIK3CA_mut 1069 EHT 1864 Rac GTPases 16 30 2.30258509299405 NA 3.2020605948843 3.75308094492449 -0.551020350040189 0.910006795888918 0.774054700584579 0.669584189230806 0.605512346203896 0.711862287799621 0.0360196945363946 NA NA NA 0.0495163273665418 82.0608635609439 a507 gain_cnaBRCA16 119 Lapatinib ERBB2, EGFR 3 10 0.693147180559945 NA -0.837220049822965 2.12606728300547 -2.96328733282843 3.38787302080945 1.33996838042114 1.57144221049606 0.874674851928314 2.21146064050937 0.0360399105096084 NA NA NA 0.26640507607338 82.0608635609439 a508 TP53_mut 1028 VX-702 p38 35 10 0.693147180559945 NA 3.53971962745991 3.03172274701212 0.507996880447781 0.569857809198257 0.905799958552845 0.776045853599752 0.891444974953473 0.560826787030752 0.0360402423516769 NA NA NA 0.120623047492917 82.0608635609439 a509 gain_cnaBRCA62 330 XMD13-2 RIPK 10 38 2.32630161961136 NA 3.01137582652824 3.90777003848325 -0.896394211955006 1.61833864817984 1.02910458702547 0.767448830837896 0.553897796955654 0.871042868972093 0.0360730456451511 NA NA NA 0.1240948005808 82.0608635609439 a510 gain_cnaBRCA64_(SDHC) 1495 AZD-2281 PARP1, PARP2 8 37 2.30258509299405 NA 4.74691945866484 3.83691223496407 0.910007223700764 1.21111651246052 1.05508247235026 0.841027969379874 0.751378760291182 0.862498664842442 0.036639100814899 NA NA NA 0.0788956459642554 83.1851271246501 a511 loss_cnaBRCA22_(SYNCRIP,ZNF292) 238 CAL-101 PI3Kdelta 19 30 2.99573227355399 2.32630161961136 4.36841853338 4.94097648726497 -0.572557953884971 1.00875592429473 0.840973929514777 0.629947597534523 0.567588194622277 0.680827233509276 0.0368541934632551 NA NA NA 0.0471164924645944 83.4298907956273 a512 MACF1_mut 1133 JNJ-26854165 MDM2 3 40 2.30258509299405 NA 1.96745054177241 3.04391817377827 -1.07646763200586 0.483788947426424 0.847792269687668 1.29114460571531 2.22507694260537 1.26973041686549 0.0369268644173975 NA NA NA 0.0398171517137598 83.4298907956273 a513 gain_cnaBRCA30_(CRNKL1,FOXA2) 1203 QL-XII-61 BTK 3 20 2.30258509299405 NA 5.88064800328942 3.97689549328673 1.90375251000268 0.540450152284211 1.44082943649567 1.37891767856032 3.52253117508891 1.32128929475019 0.0370082227556696 NA NA NA 0.00314412892891026 83.4298907956273 a514 loss_cnaBRCA34 206 Ruxolitinib JAK1, JAK2, TYK2 5 44 1.65632149833295 0.0237165266173161 3.7988445305105 4.4351940798105 -0.636349549299999 1.18245189878812 0.548896424169405 1.01296556903586 0.538161044818978 1.15932536864843 0.0370351186362833 NA NA NA 0.297351439096906 83.4298907956273 a515 loss_cnaBRCA22_(SYNCRIP,ZNF292) 59 WZ-1-84 BMX 3 9 2.32630161961136 NA 2.36827691942693 3.95977040120667 -1.59149348177974 1.38611972872981 0.868204966747375 1.60170529501525 1.14816451190557 1.8330849773206 0.0371529031856508 NA NA NA 0.174389516240976 83.5327118420681 a516 MLL3_mut 228 KIN001-102 AKT1 3 46 2.32630161961136 NA 0.323343726336121 2.04937923965255 -1.72603551331642 1.17286480349409 1.36018854436702 1.2759495875448 1.47164064278712 1.2689678357199 0.0374663205983199 NA NA NA 0.115012845700276 83.5578576012136 a517 gain_cnaBRCA62 205 BMS-708163 g-secretase 10 38 2.32630161961136 0.940007258491471 4.50328416970274 5.00001513549249 -0.496730965789749 0.750398426584686 0.626247775466536 0.76139044297098 0.661956299736045 0.793185996420825 0.0374962046199624 NA NA NA 0.0773761389064447 83.5578576012136 a518 gain_cnaBRCA27_(CLTC,PPM1D) 1032 Afatinib ERBB2, EGFR 10 35 -0.693147180559945 NA -0.759850785024644 0.590563836515078 -1.35041462153972 2.00800381094931 1.68179691043791 0.769424532101191 0.672515965445951 0.802959390137125 0.0375744350487109 NA NA NA 0.0745392385641751 83.5578576012136 a519 MLL3_mut 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 3 45 2.07944154167984 NA 1.87903379864103 3.30332142762795 -1.42428762898692 0.614185938994562 1.13314286772975 1.27668877851401 2.31898442891498 1.2569356164598 0.0375998855391468 NA NA NA 0.0360179112531575 83.5578576012136 a520 loss_cnaBRCA7_(FAS,PTEN) 190 Bleomycin DNA damage 4 44 4.15888308335967 NA -0.622285654619963 2.32391595732482 -2.94620161194478 1.03110708638626 2.71300927587595 1.11757968531258 2.85731875073266 1.08595338694282 0.0376910629020557 NA NA NA 0.00223381139142987 83.5578576012136 a521 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 306 TG101348 JAK2 5 43 2.32630161961136 NA 2.10835486032059 3.35471847483579 -1.2463636145152 1.22489822192609 1.23376245909896 1.01084305912105 1.01752422544573 1.01021359932239 0.0377465195974759 NA NA NA 0.0841258534534673 83.5578576012136 a522 BRCA2_mut 190 Bleomycin DNA damage 6 42 4.15888308335967 NA -0.075221208069485 2.3860592083864 -2.46128041645589 3.68577037166451 2.47812934242528 0.933601337554591 0.667779098605203 0.993200949732149 0.037763868849659 NA NA NA 0.166900326430097 83.5578576012136 a523 gain_cnaBRCA12_(TERT) 165 DMOG Prolyl-4-Hydroxylase 9 37 8.29404964010203 NA 6.62726095497605 7.79929075642504 -1.17202980144899 1.04816177325322 1.5510002013886 0.795997566272899 1.1181764412294 0.755660637825632 0.0377943559784626 NA NA NA 0.0145140323393326 83.5578576012136 a524 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 37 Crizotinib MET, ALK 5 9 0.693147180559945 NA 3.21048090498924 2.34218780296969 0.868293102019557 0.363281535740627 0.776521796238177 1.30019274492265 2.39013827182093 1.1181825239497 0.0379985517932058 NA NA NA 0.0150110869261019 83.5578576012136 a525 loss_cnaBRCA57 152 CP466722 ATM 5 44 2.77258872223978 NA 3.65343191334277 2.62522242514706 1.0282094881957 1.45687727346087 0.970435183755245 1.00716142374248 0.705762597115097 1.05953442889085 0.0380826387217858 NA NA NA 0.191856456201899 83.5578576012136 a526 BRCA1_mut 298 OSI-930 KIT, VEGFR, PDGFR 4 44 2.32630161961136 NA 4.77097855969827 3.83540263614622 0.935575923552051 0.669012236473901 0.850591397624426 1.11385158566847 1.39844366447332 1.09991228005006 0.0383043616493993 NA NA NA 0.0602233642331648 83.5578576012136 a527 loss_cnaBRCA57 224 AS605240 PI3Kgamma 5 44 2.99573227355399 2.32630161961136 4.64322348035368 3.11423780261593 1.52898567773776 1.29065765771445 1.54033640081266 1.00545919826366 1.18465626310647 0.992631010298197 0.0383947442517854 NA NA NA 0.0538825431287686 83.5578576012136 a528 ASH1L_mut 178 BAY 61-3606 SYK 3 45 2.07944154167984 NA 1.25549857335329 3.21843643821416 -1.96293786486087 0.184854241421471 1.57845417896708 1.2711354241015 10.6188413626135 1.24358241817661 0.038400028226442 NA NA NA 9.41151787078472e-09 83.5578576012136 a529 gain_cnaBRCA47_(EGFR) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 36 -1.38629436111989 0.693147180559945 -1.61282352453139 -0.0838069428600872 -1.5290165816713 0.712665567719888 1.71118187811093 0.943619526734702 2.14548962504707 0.893544164550917 0.0385126419796203 NA NA NA 0.00158672893047525 83.5578576012136 a530 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1043 JNK Inhibitor VIII JNK 16 27 2.30258509299405 NA 5.09958642144333 4.61821696472202 0.481369456721303 0.751337975110376 0.690877181779294 0.674572879438988 0.640682985111444 0.69675112945774 0.0385134922778246 NA NA NA 0.0451714648236265 83.5578576012136 a531 gain_cnaBRCA63 301 PHA-793887 CDK-pan 7 41 2.32630161961136 NA 1.74802864237797 3.12275012191198 -1.37472147953401 2.08432356413668 1.48750127036381 0.871069515122058 0.659552817608439 0.924181717974454 0.0385555675048374 NA NA NA 0.137602725600105 83.5578576012136 a532 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 173 FH535 unknown 15 33 3.46573590279973 NA 1.01194647278934 1.82802152356451 -0.816075050775174 1.03123700302292 1.30833558383137 0.663139177610434 0.791355477337382 0.623750558236255 0.0385924861189934 NA NA NA 0.0259294169768163 83.5578576012136 a533 loss_cnaBRCA18 309 Y-39983 ROCK 16 33 2.99573227355399 NA 4.47989899074677 5.15562671464865 -0.675727723901878 1.08123624735627 1.02361168477264 0.648274172934451 0.624958445070725 0.660140690023451 0.0386081918165146 NA NA NA 0.0459777482646672 83.5578576012136 a534 gain_cnaBRCA58_(CCND1) 304 SB52334 ALK5 10 39 2.99573227355399 NA 5.03742637999107 4.11329312418728 0.924133255803785 1.10334368429003 1.25228258222036 0.754293041098305 0.83757515356463 0.737959042890505 0.0386095928302706 NA NA NA 0.0359441076667898 83.5578576012136 a535 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 8 35 0.693147180559945 NA 0.592488138915526 1.93096619484523 -1.3384780559297 2.29689078264233 1.41278129417137 0.837217947851044 0.582734741261803 0.947406411347446 0.0386634638729456 NA NA NA 0.15132900484468 83.5578576012136 a536 gain_cnaBRCA62 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 9 39 2.77258872223978 NA 0.42883263670334 -0.636225625748092 1.06505826245143 1.29622029361563 1.365247533413 0.786894456930975 0.821664548608939 0.780120993728423 0.0387366859585097 NA NA NA 0.047412123874358 83.5578576012136 a537 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 326 GSK690693 AKT 14 34 2.32630161961136 NA 2.05187832547892 3.30510174905132 -1.2532234235724 2.03431581596319 1.77983446010771 0.675484750955546 0.616041724563318 0.704123586581508 0.038801376161709 NA NA NA 0.0570692923640429 83.5578576012136 a538 MLL3_mut 226 GSK1070916 AURKB 3 46 0.940007258491471 2.32630161961136 0.177591728798084 2.5491448383665 -2.37155310956842 2.62443525565949 1.83404406689399 1.26517967307829 0.903643214079775 1.29307313405218 0.0390304486951011 NA NA NA 0.255899207446941 83.5578576012136 a539 TP53_mut 1017 Olaparib PARP1, PARP2 35 10 1.6094379124341 NA 4.21875668709752 3.56779303533875 0.650963651758772 0.767878066119988 1.11691936570903 0.763292019497958 0.847743516165304 0.582820633023526 0.0390463786311942 NA NA NA 0.110268284010811 83.5578576012136 a540 loss_cnaBRCA33 298 OSI-930 KIT, VEGFR, PDGFR 6 42 2.32630161961136 NA 3.23186679184809 4.01072451138425 -0.778857719536157 0.385432411086234 0.879791796755565 0.926917921053967 2.02073748116087 0.885275041672785 0.0390924684028313 NA NA NA 0.00210275073555655 83.5578576012136 a541 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 329 QL-XI-92 DDR1 6 42 2.32630161961136 NA 4.99151859781264 4.14788031253266 0.843638285279981 0.586590555187147 0.942163169511414 0.926802928259888 1.43820639084587 0.89542694151107 0.0391156822496498 NA NA NA 0.0143088649067037 83.5578576012136 a542 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1031 Elesclomol HSP70 5 39 -1.6094379124341 NA -1.444468529957 -3.17413170398276 1.72966317402576 1.33158808107524 1.74524721544534 1.01139992642102 1.29894762397473 0.991070582275302 0.0391450727010753 NA NA NA 0.0395520639307802 83.5578576012136 a543 loss_cnaBRCA22_(SYNCRIP,ZNF292) 119 Lapatinib ERBB2, EGFR 3 10 0.693147180559945 NA -0.807119384791509 2.11703708349603 -2.92415646828754 3.43999463614671 1.33247998871042 1.54025876223684 0.850046810411023 2.1945218637899 0.0391846590184463 NA NA NA 0.276549893529537 83.5578576012136 a544 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 281 CH5424802 ALK 5 43 1.63315443905142 NA 2.6554190975618 3.6821955014526 -1.0267764038908 1.84177781053894 0.908635307761383 1.00260691675028 0.557492004744236 1.13002036693961 0.0392614013128808 NA NA NA 0.282924309927424 83.5666964986609 a545 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 170 Shikonin unknown 7 40 2.77258872223978 NA 0.847319905667747 -0.144041575136795 0.991361480804542 2.01376538832945 0.93599612481999 0.869489211223204 0.492292442083803 1.05915126624611 0.0393555419019434 NA NA NA 0.245066402925886 83.5666964986609 a546 gain_cnaBRCA30_(CRNKL1,FOXA2) 1036 PLX4720 BRAF 4 39 2.30258509299405 NA 5.76227923485321 4.47706044278429 1.28521879206892 0.806051379113379 1.17358090735324 1.11692507789291 1.59446261785769 1.09512585286298 0.0394472835683669 NA NA NA 0.039438619479782 83.5666964986609 a547 ARID1A_mut 1047 Nutlin-3a MDM2 4 39 2.07944154167984 1.38629436111989 3.23256227606362 4.30688121339139 -1.07431893732777 1.00420962124729 0.958598560155028 1.1167448730912 1.06981541960671 1.12071828811638 0.0394774876800825 NA NA NA 0.118258616130432 83.5666964986609 a548 BRCA2_mut 344 THZ-2-49 CDK9 6 43 2.99573227355399 NA 2.93352705289655 1.62505377804671 1.30847327484984 2.13225394372248 1.3081004107503 0.922292230247598 0.613657336032645 1.00028504241454 0.0396423690723804 NA NA NA 0.197234954000631 83.7625896877906 a549 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 64 CMK RSK 3 9 1.38629436111989 NA 3.38309219746549 1.81117790208886 1.57191429537663 0.803515421553056 1.04148475224506 1.57437239437166 1.95629636123024 1.50930130468848 0.0398471465396547 NA NA NA 0.0469165408822394 83.940935517796 a550 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1022 AZD7762 CHEK1, CHEK2 6 39 0.693147180559945 NA 2.15818793813773 0.711914185230831 1.44627375290689 1.56571792345525 1.55546208281117 0.92908889781996 0.923712842039412 0.929803284110311 0.0399366562831242 NA NA NA 0.075285824896249 83.940935517796 a551 gain_cnaBRCA14_(RAD21) 53 CGP-60474 CDK1,CDK2,CDK5,CDK7,CDK9 6 6 -1.36257783450257 NA -2.55158805499129 -0.848846379069654 -1.70274167592163 0.708588606972288 1.61907202013766 1.36252212531391 2.40300459133437 1.05167753796206 0.0399561471748537 NA NA NA 0.0511319341436614 83.940935517796 a552 POLR2B_mut 266 Zibotentan, ZD4054 Endothelin A Receptor 3 46 2.99573227355399 NA 5.1824009263619 5.77853754481654 -0.596136618454638 0.172007351642874 0.483227788037238 1.257237084889 3.46576243841224 1.23365549997861 0.0402203527324672 NA NA NA 0.0059108003084567 83.940935517796 a553 CDH1_mut 179 5-Fluorouracil DNA antimetabolite 4 45 3.46573590279973 NA 2.4664497898903 4.18147907900184 -1.71502928911154 1.705810908417 1.54758506252141 1.10067265401565 1.00540410466896 1.10819710699283 0.0402477333011011 NA NA NA 0.135385951756833 83.940935517796 a554 gain_cnaBRCA19 291 KIN001-266 MAP3K8 (COT) 4 45 2.99573227355399 NA 2.63029213797704 3.88070927749375 -1.25041713951671 0.0784581112277637 1.1740089232107 1.10062658162437 15.9373851849015 1.06508316486816 0.0402557257217774 NA NA NA 9.21386496682102e-09 83.940935517796 a555 gain_cnaBRCA30_(CRNKL1,FOXA2) 1166 QL-VIII-58 MTOR, ATR 3 23 2.30258509299405 NA -0.294156655492346 -1.67879278020285 1.38463612471051 1.31771370859549 1.01206959726475 1.33013616064069 1.05078676474145 1.36812342595081 0.0403933099295748 NA NA NA 0.204003003756914 83.940935517796 a556 gain_cnaBRCA31 1495 AZD-2281 PARP1, PARP2 14 31 2.30258509299405 NA 4.50651839747806 3.7693500257515 0.737168371726554 1.0453415699182 1.10065688722967 0.67989953902552 0.705193778703587 0.669753108602253 0.0405827668533449 NA NA NA 0.0405433325027116 83.940935517796 a557 loss_cnaBRCA29_(MAP2K4) 163 JQ1 BRD4 7 40 0.940007258491471 NA -0.713860764514759 0.496127808676637 -1.2099885731914 1.15791451856573 1.43592798286543 0.863014903242507 1.04497227886059 0.842652687063619 0.0407752635748258 NA NA NA 0.0350481652308305 83.940935517796 a558 gain_cnaBRCA10_(MDM2,NUP107) 133 Doxorubicin DNA intercalating 4 44 0.0237165266173161 NA 0.747763003427721 -1.19231843689409 1.94008144032182 1.03469266727661 1.80606936798727 1.0985351439808 1.87503159312829 1.0742009552401 0.0409168748593898 NA NA NA 0.0219172891610717 83.940935517796 a559 gain_cnaBRCA16 1024 CEP-701 FLT3, JAK2, NTRK1, RET 15 30 0.693147180559945 NA 1.23735096190774 0.319677902579686 0.917673059328058 1.3876710250194 1.37339070553427 0.665918380972784 0.661304475471937 0.668180624515781 0.0410965902852215 NA NA NA 0.0450663644876011 83.940935517796 a560 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1005 Cisplatin DNA crosslinker 8 37 1.79175946922805 2.30258509299405 4.43636318369445 3.50440146896814 0.931961714726315 1.21672704572542 1.11859905326523 0.821002001086192 0.765957918006723 0.83315081664506 0.0411131005126509 NA NA NA 0.0751591448196935 83.940935517796 a561 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 286 KIN001-236 TIE2 15 34 2.32630161961136 NA 4.20646185852359 4.68729904937319 -0.480837190849598 0.462629551410705 0.828671014238077 0.65079067136706 1.03935684476569 0.580251007441963 0.0411636997969698 NA NA NA 0.0129524013016099 83.940935517796 a562 POLR2B_mut 1059 AZD8055 MTORC1/2 3 40 0.693147180559945 NA -1.00262694753573 0.215410059738154 -1.21803700727389 1.43990784895846 0.934516541645558 1.26178546269273 0.845913166009156 1.30338731632197 0.0412007399400827 NA NA NA 0.278808360760924 83.940935517796 a563 gain_cnaBRCA13_(FGFR1,WHSC1L1) 263 FR-180204 ERK 11 38 2.99573227355399 NA 5.75134437396436 5.24398872277654 0.507355651187818 0.601389474045578 0.732014693281139 0.718381353621087 0.843639061014504 0.6930949007508 0.041290206017944 NA NA NA 0.0300333778980468 83.940935517796 a564 gain_cnaBRCA30_(CRNKL1,FOXA2) 1529 MLN4924 NEDD8-activating enzyme 4 33 0 NA 1.98534537931225 0.17332071393003 1.81202466538222 1.69352401296377 1.60839170800369 1.12139640624883 1.06997282088198 1.1266065700073 0.0413415484726795 NA NA NA 0.117915062636154 83.940935517796 a565 ASH1L_mut 1047 Nutlin-3a MDM2 3 40 2.07944154167984 1.38629436111989 3.07773256806324 4.29163546805822 -1.21390289999498 1.21745076197096 0.948068102960535 1.26059710457208 0.997085827134211 1.28039630929922 0.0413825318140927 NA NA NA 0.222587150875315 83.940935517796 a566 loss_cnaBRCA36_(FAT1,IRF2) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 9 38 0.940007258491471 NA 2.64706466936274 1.70903623577389 0.938028433588848 0.699396073001381 1.28895362436972 0.778185060174467 1.34119774159355 0.727744129698641 0.0414432959293772 NA NA NA 0.00649019553064976 83.940935517796 a567 gain_cnaBRCA61_(NOTCH2) 167 OSU-03012 PDPK1 (PDK1) 3 45 2.77258872223978 NA 3.58441396373188 2.15888336517447 1.42553059855741 1.06121015770783 1.14322680129519 1.25070286484284 1.34330659031431 1.24693595089128 0.041474067941553 NA NA NA 0.13650847761179 83.940935517796 a568 loss_cnaBRCA60 206 Ruxolitinib JAK1, JAK2, TYK2 3 46 1.65632149833295 0.0237165266173161 3.63230250573735 4.41838814450005 -0.7860856387627 1.65239053966952 0.540886948605517 1.24870487358996 0.475726300708499 1.45332705991398 0.0415338494212649 NA NA NA 0.496848837579771 83.940935517796 a569 gain_cnaBRCA47_(EGFR) 185 OSI-906 IGF1R 7 41 0.940007258491471 NA 2.09857328006241 3.02920738644399 -0.930634106381577 1.6343968363072 0.977305791716386 0.857092584561782 0.569405229934411 0.952244542362895 0.0416321220180801 NA NA NA 0.188533878901102 83.940935517796 a570 NF1_mut 1004 Vinblastine Microtubules 4 41 -2.30258509299405 NA -2.22156658180362 -3.57594999212312 1.35438341031951 1.31088474710528 1.22606029996441 1.09918748245087 1.03318267552528 1.10466296833755 0.0417810883708985 NA NA NA 0.127650493606561 83.940935517796 a571 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 15 32 -2.30258509299405 NA 0.304545995271428 -0.349270725864697 0.653816721136125 0.736480939718425 1.09547259373643 0.65530723966975 0.887757830346697 0.596835306400585 0.041905919386284 NA NA NA 0.0208056408261018 83.940935517796 a572 gain_cnaBRCA31 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 16 30 1.63315443905142 NA 2.58385707013225 1.59138852245739 0.99246854767486 1.51577781005285 1.53774896543599 0.648547529423351 0.654758593965863 0.645403489114668 0.0419612099017976 NA NA NA 0.0435134476704183 83.940935517796 a573 gain_cnaBRCA30_(CRNKL1,FOXA2) 1052 RO-3306 CDK1 4 39 1.6094379124341 NA 4.6765323728958 3.4076365388839 1.2688958340119 0.493615245167362 1.18765401351538 1.1022873548985 2.5706171890653 1.06840529276371 0.041967983448827 NA NA NA 0.00419323537898466 83.940935517796 a574 PTEN_mut 1529 MLN4924 NEDD8-activating enzyme 6 31 0 NA -0.90590614758599 0.616012966530837 -1.52191911411683 0.785724082302733 1.71628381431234 0.94149965997809 1.93696381261029 0.88675258801914 0.0419926003327526 NA NA NA 0.00345007895033417 83.940935517796 a575 gain_cnaBRCA63 1030 KU-55933 ATM 5 37 2.30258509299405 NA 5.00081913738057 4.11709397905699 0.883725158323585 0.869437264872217 0.884391215313726 1.00092641726251 1.0164334955823 0.999246875162702 0.0420173188586207 NA NA NA 0.0845533624609383 83.940935517796 a576 loss_cnaBRCA33 196 Phenformin AAPK1 (AMPK) agonist 5 43 8.29404964010203 NA 5.65817833505141 7.38152875253871 -1.7233504174873 1.64374445828612 1.75358002795703 0.987987603868932 1.04842964415781 0.982761202803534 0.0420819459866259 NA NA NA 0.0775156674442263 83.940935517796 a577 BRCA1_mut 1019 Bosutinib SRC, ABL, TEC 4 41 0.693147180559945 NA 1.76577793253288 2.75009323045897 -0.984315297926083 0.783030822573662 0.904984793931188 1.0973236465207 1.2570581764468 1.08765948834376 0.0421127292266747 NA NA NA 0.0801803558844417 83.940935517796 a578 loss_cnaBRCA33 262 VX-11e ERK 6 43 1.63315443905142 NA 2.75259843038611 3.91972545821516 -1.16712702782905 2.57164848508442 1.02608435352963 0.91015449346597 0.453843919415268 1.13745719230027 0.0421991489439501 NA NA NA 0.319599800131084 83.940935517796 a579 gain_cnaBRCA30_(CRNKL1,FOXA2) 1047 Nutlin-3a MDM2 4 39 2.07944154167984 1.38629436111989 5.16868664324948 4.10830435521848 1.060382288031 0.360308179968804 0.995548022367981 1.10069348998712 2.94298699552924 1.06512419713195 0.042250812912296 NA NA NA 0.00165693643974135 83.940935517796 a580 ASH1L_mut 179 5-Fluorouracil DNA antimetabolite 3 46 3.46573590279973 NA 2.22066910972873 4.16022500837951 -1.93955589865078 1.72992418268577 1.55159524470129 1.243624621138 1.12117971299733 1.25003985754299 0.0423336100771764 NA NA NA 0.186402822632522 83.940935517796 a581 gain_cnaBRCA30_(CRNKL1,FOXA2) 266 Zibotentan, ZD4054 Endothelin A Receptor 5 44 2.99573227355399 NA 6.16177511533676 5.69434214236279 0.467432972973967 0.615410692711761 0.459322868343422 0.984878750206622 0.759546394805489 1.01765665328137 0.0423494066498733 NA NA NA 0.16662440899003 83.940935517796 a582 loss_cnaBRCA17 275 I-BET BRD2, BRD3, BRD4 11 38 2.99573227355399 NA 3.3131123963014 4.24904935652479 -0.935936960223388 1.02165535237134 1.37765191755608 0.714436587106614 0.916098523881862 0.679371144696492 0.042368632789461 NA NA NA 0.0223891426393547 83.940935517796 a583 MLL3_mut 219 AT-7519 CDK9 3 46 2.32630161961136 NA -0.364892722082351 1.80484136589555 -2.1697340879779 0.551426849576212 1.78116878198364 1.24228454710445 3.93476322316443 1.21815187304234 0.0425467999424162 NA NA NA 0.00244055660175487 83.940935517796 a584 ASH1L_mut 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 39 1.38629436111989 0.693147180559945 2.26809789708124 3.52307070472938 -1.25497280764815 1.08104157925178 0.995440252024935 1.25510536922124 1.16089226514003 1.26072137940501 0.0425649602726627 NA NA NA 0.175426610305599 83.940935517796 a585 PTEN_mut 1495 AZD-2281 PARP1, PARP2 8 37 2.30258509299405 NA 3.27176021320631 4.15586558533349 -0.884105372127179 1.07054886881271 1.08814237700518 0.814620107465997 0.825843077212991 0.812490525881771 0.0426362396960002 NA NA NA 0.0598701081360261 83.940935517796 a586 ASH1L_mut 1018 ABT-888 PARP1, PARP2 3 42 1.6094379124341 NA 3.65973940948681 4.45617167648873 -0.796432267001915 0.695400610368448 0.635269191440227 1.24795157153868 1.14528554494644 1.25369257274434 0.0427354593167826 NA NA NA 0.179714363091168 83.940935517796 a587 loss_cnaBRCA17 179 5-Fluorouracil DNA antimetabolite 11 38 3.46573590279973 NA 3.17923242957716 4.29107371024461 -1.11184128066744 1.63220128682455 1.53982118978298 0.712748574142926 0.681191278087112 0.722058696194552 0.0428375663996201 NA NA NA 0.0615921508258995 83.940935517796 a588 BRCA1_mut 184 BMS-754807 IGF1R 4 44 0.940007258491471 NA 3.23876373807833 1.48033306528002 1.75843067279832 0.305187654953127 1.67033396033369 1.08758063828699 5.76180144989282 1.05274197529159 0.0428798010437569 NA NA NA 2.1461404849001e-06 83.940935517796 a589 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 194 AUY922 HSP90 7 40 -1.36257783450257 NA -1.18642242184915 -2.60502888908155 1.4186064672324 2.33804655107524 1.53259274924067 0.853201880292929 0.606748598132061 0.925625198171695 0.0430126255489072 NA NA NA 0.165939974348775 83.940935517796 a590 gain_cnaBRCA16 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 15 31 1.63315443905142 NA 2.61273925761261 1.60942838489188 1.00331087272073 1.59359217266774 1.50097933135 0.655306946389505 0.629590738414049 0.66843750061391 0.0430477358642654 NA NA NA 0.0515387856857209 83.940935517796 a591 gain_cnaBRCA31 1013 Nilotinib ABL 12 28 0.693147180559945 NA 3.66556615960392 3.00462504932055 0.660941110283368 0.64166572748355 1.00546603513568 0.722220766650274 1.03003960157793 0.65734802289386 0.0430600142522768 NA NA NA 0.0181417010900436 83.940935517796 a592 gain_cnaBRCA15 1003 Camptothecin TOP1 21 24 -2.30258509299405 NA -2.02270735177805 -2.97253377474933 0.949826422971279 1.44965041508181 1.58981014692383 0.622338507611611 0.655210672234849 0.597446446551575 0.0432573368016246 NA NA NA 0.0420292196501352 83.940935517796 a593 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 177 GSK-650394 SGK3 6 41 2.77258872223978 NA 2.71990523055904 4.20388274986885 -1.48397751930982 1.32403728667719 1.66696591662732 0.909063684436696 1.12079737802098 0.890226671408056 0.0432739840021063 NA NA NA 0.0402566677091865 83.940935517796 a594 gain_cnaBRCA31 158 PF-562271 FAK 14 31 0.940007258491471 NA 2.90532241763698 2.074895013 0.830427404636972 1.39306014333891 1.16502462480644 0.670563745195958 0.596117410011164 0.712798156326473 0.0432835196622621 NA NA NA 0.0649960712756588 83.940935517796 a595 gain_cnaBRCA63 1038 NU-7441 PRKDC (DNAPK) 5 38 0.693147180559945 NA 3.68715193033289 2.78835357953344 0.898798350799453 1.17976760075297 0.871269234786002 0.99204816330761 0.761843561584338 1.03159656615238 0.0433054575653652 NA NA NA 0.165950044021577 83.940935517796 a596 loss_cnaBRCA18 279 BIX02189 MAP2K5 (MEK5) 16 33 2.99573227355399 NA 4.65771720639242 5.20657487516479 -0.548857668772365 0.924409683170514 0.839898174107417 0.632496023700276 0.593738554198079 0.653481202475111 0.0433664034694679 NA NA NA 0.0547214422332436 83.940935517796 a597 loss_cnaBRCA17 346 THZ-2-102-1 CDK7 10 38 0.916290731874155 2.99573227355399 -2.76811070509218 -0.95806472646475 -1.81004597862743 1.84480916300274 2.57751613005533 0.738356263397215 0.981156216549396 0.702244287638492 0.0433670780214195 NA NA NA 0.0205669610859324 83.940935517796 a598 gain_cnaBRCA14_(RAD21) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 20 26 1.63315443905142 NA 2.47198151714543 1.5247591712665 0.947222345878933 1.42476310247959 1.60755424703642 0.618573662574275 0.664827959279988 0.589231963789196 0.0434052726164562 NA NA NA 0.0404045918001483 83.940935517796 a599 loss_cnaBRCA33 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 6 43 3.68887945411394 NA 2.54466888295089 3.5871036959893 -1.04243481303841 0.479722899458972 1.20779295424737 0.904566082220843 2.17299364740366 0.863090655871556 0.04342397476048 NA NA NA 0.00130303174187675 83.940935517796 a600 gain_cnaBRCA47_(EGFR) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 7 38 2.30258509299405 NA 2.27314979989309 3.34334119527853 -1.07019139538543 0.550392538743117 1.33079682011022 0.855149238768374 1.9444147949922 0.804173393874506 0.0436068821265944 NA NA NA 0.00173196946179403 83.9466957715991 a601 loss_cnaBRCA18 1011 ABT-263 BCL2, BCL2L1, BCL2L2 12 31 0.693147180559945 NA 0.864299095087577 1.99845589644697 -1.1341568013594 2.07156815618697 1.39193613908649 0.707602139843785 0.547487080245037 0.814805197962409 0.0436958183869742 NA NA NA 0.100558299859888 83.9466957715991 a602 gain_cnaBRCA31 308 XL-880 MET 16 33 1.63315443905142 NA 2.50554962061715 1.52878597261248 0.976763648004676 1.65823601489486 1.49216118915353 0.631350560639487 0.589037772205549 0.65459660464616 0.0437309583005638 NA NA NA 0.0559930739011754 83.9466957715991 a603 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 229 LY317615 PRKCB (PKCbeta) 7 42 2.99573227355399 2.32630161961136 2.23134709975 3.54645573404825 -1.31510863429825 1.29558485897683 1.59108748544838 0.844919042036635 1.01506946857718 0.826547029202259 0.0440095790929693 NA NA NA 0.0389847136608192 83.9466957715991 a604 loss_cnaBRCA33 1030 KU-55933 ATM 5 37 2.30258509299405 NA 3.45084267701639 4.32655025748458 -0.875707580468192 0.92447841477289 0.879148896178416 0.99085876846905 0.947245026465352 0.996085628128315 0.0440185924200617 NA NA NA 0.101681810847755 83.9466957715991 a605 gain_cnaBRCA63 1054 PD-0332991 CDK4, CDK6 5 37 1.38629436111989 0.693147180559945 4.10843087983945 2.71729309756927 1.39113778227018 1.08305684151726 1.43567448611428 0.990554918832555 1.28445500637004 0.968978550308681 0.0440802694158877 NA NA NA 0.0411260444694845 83.9466957715991 a606 loss_cnaBRCA57 258 STF-62247 stimulates autophagy 5 44 2.32630161961136 NA 5.44360312833374 4.53848378913761 0.905119339196134 0.198664794674164 0.967444752800907 0.976212227035733 4.55601275847915 0.935577289117202 0.044118396384108 NA NA NA 7.88392242583846e-06 83.9466957715991 a607 CDH1_mut 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 39 1.6094379124341 NA 4.0883445600354 2.41134107334039 1.67700348669501 0.81255196437225 1.58133068912171 1.09026373918456 2.06387229398997 1.06050144870485 0.0441431492496026 NA NA NA 0.0138354797137742 83.9466957715991 a608 TP53_mut 346 THZ-2-102-1 CDK7 37 11 0.916290731874155 2.99573227355399 -1.7345393871964 0.0082173336076835 -1.74275672080408 2.28298393827957 2.98319137144248 0.710670845845355 0.763367928955909 0.584192062730926 0.0441523804570294 NA NA NA 0.0959339938947393 83.9466957715991 a609 gain_cnaBRCA19 304 SB52334 ALK5 4 45 2.99573227355399 NA 3.08492228310305 4.41006681135117 -1.32514452824812 1.37137905831978 1.21779407255853 1.07895737908167 0.966286104639581 1.08815156692629 0.0441721470126464 NA NA NA 0.146792707677401 83.9466957715991 a610 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 140 Vinorelbine Microtubules 5 42 -2.74887219562247 NA -4.9870730492339 -3.43466759983535 -1.55240544939855 1.08100111295463 1.62611595698271 0.979268854797849 1.43608126836749 0.95467081712861 0.0442244446158351 NA NA NA 0.027182006833781 83.9466957715991 a611 gain_cnaBRCA63 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 6 42 2.77258872223978 NA 0.634832885719275 -0.589578642575266 1.22441152829454 1.44850673970848 1.34529970300423 0.902360659035289 0.845292254933491 0.910140339405613 0.0443324846090876 NA NA NA 0.0962893877971087 83.9827100883788 a612 NF1_mut 294 MPS-1-IN-1 MPS1 5 44 2.99573227355399 NA 5.74650834306747 4.64401876657768 1.10248957648979 0.53229198468087 1.17108515438526 0.974915816836037 2.07121205695175 0.941425627642357 0.0443884779118126 NA NA NA 0.00446636727130019 83.9827100883788 a613 loss_cnaBRCA36_(FAT1,IRF2) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 9 37 1.63315443905142 NA 0.99064461727541 2.16669100649618 -1.17604638922077 1.48888776948913 1.54174133704912 0.767520432317434 0.789882497069811 0.762803954826636 0.0448400291217332 NA NA NA 0.0555502012039672 84.2933747183766 a614 gain_cnaBRCA30_(CRNKL1,FOXA2) 173 FH535 unknown 5 43 3.46573590279973 NA 2.65013197322405 1.44774994193834 1.2023820312857 2.54379706996174 1.02553931648624 0.974311344606555 0.472672150417953 1.17243874706372 0.0448792559024741 NA NA NA 0.352140650192576 84.2933747183766 a615 gain_cnaBRCA58_(CCND1) 345 KIN001-270 CDK9 10 39 2.99573227355399 NA 5.49463582209981 5.00834369742713 0.486292124672685 0.456717736380702 0.7065619732934 0.730152225951139 1.06475419265814 0.688251198130574 0.0449689796862609 NA NA NA 0.0147724776176179 84.2933747183766 a616 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1006 Cytarabine DNA synthesis 17 28 0.693147180559945 NA 1.78875747912062 0.856254293595653 0.93250318552497 1.63586768423331 1.36181508279499 0.634455271810302 0.570035825337557 0.684750225861134 0.0451374686384283 NA NA NA 0.0581599857217506 84.2933747183766 a617 loss_cnaBRCA57 300 CX-5461 RNA Pol I 5 44 2.32630161961136 NA 5.34957749031422 3.74904572537253 1.60053176494168 0.316978802660242 1.72027548997405 0.971172235041528 5.04933374569288 0.930392704116143 0.0451764766719384 NA NA NA 3.88285795604115e-06 84.2933747183766 a618 CDH1_mut 294 MPS-1-IN-1 MPS1 4 45 2.99573227355399 NA 3.6411909035295 4.85565786290305 -1.21446695937355 0.723578766548476 1.15378567435702 1.07358612950779 1.67841707844282 1.0525932037164 0.045192820676577 NA NA NA 0.0332979157368343 84.2933747183766 a619 BRCA2_mut 140 Vinorelbine Microtubules 6 41 -2.74887219562247 NA -4.84475488340107 -3.4176311009475 -1.42712378245357 0.836010664007061 1.65606384523495 0.899811342467215 1.70706408888765 0.861756499642141 0.0453507264052832 NA NA NA 0.00603242483973522 84.2933747183766 a620 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 32 VX-680 AURKA, AURKB, AURKC, FLT3, ABL1, JAK2 3 9 0.693147180559945 NA 3.26054303718249 0.501340643205537 2.75920239397696 0.0962102061979296 2.02523208414801 1.52279445207757 28.6788949220268 1.36241293804 0.0454605528467603 NA NA NA 0.00346761493699487 84.2933747183766 a621 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 86 A-443654 AKT1, AKT2, AKT3 3 9 0.0237165266173161 NA -0.075962947442431 -1.67485182241979 1.59888887497735 0.742021709901679 1.11488978068523 1.52137019965132 2.15477371300796 1.43412281884461 0.0456259971293215 NA NA NA 0.0342281821896543 84.2933747183766 a622 loss_cnaBRCA24 1066 AZD6482 PI3Kbeta 3 40 1.6094379124341 NA 3.55234328126785 1.84830096473291 1.70404231653493 1.24619853054705 1.3874373102537 1.23402384532969 1.36739233337637 1.22819409853072 0.0456356013079182 NA NA NA 0.130856328656879 84.2933747183766 a623 loss_cnaBRCA36_(FAT1,IRF2) 165 DMOG Prolyl-4-Hydroxylase 9 37 8.29404964010203 NA 6.66136763066771 7.79099453801356 -1.12962690734585 1.76987586729668 1.40473045415515 0.764373687574122 0.638252053841067 0.804159192252466 0.0456848820115698 NA NA NA 0.103245297681733 84.2933747183766 a624 loss_cnaBRCA57 345 KIN001-270 CDK9 5 44 2.99573227355399 NA 5.68709197230586 5.04173414907106 0.645357823234797 0.481833203739044 0.68082794558472 0.968699835606583 1.33938013865959 0.947901488797642 0.0457035492390767 NA NA NA 0.0354382487108958 84.2933747183766 a625 loss_cnaBRCA18 257 NPK76-II-72-1 PLK3 16 33 2.32630161961136 NA 2.83491269605544 3.79122580058992 -0.956313104534486 1.62013441091844 1.48498599924447 0.625279695137285 0.590267756853804 0.64398796017002 0.0457079839994052 NA NA NA 0.0565629435695241 84.2933747183766 a626 loss_cnaBRCA18 260 NG-25 MAP3K7 (TAK1) 16 33 2.32630161961136 NA 2.68615773684992 3.46152433453006 -0.77536659768014 1.04898497279554 1.32060228139489 0.625096580726786 0.739158918181444 0.587131045132797 0.0457688053264819 NA NA NA 0.0324280563683617 84.2933747183766 a627 gain_cnaBRCA63 273 CUDC-101 HDAC, EGFR 7 42 1.63315443905142 NA 1.05952701834996 -0.207677766235483 1.26720478458544 2.64291204215981 1.26712883372034 0.836964363760297 0.479472931513025 1.0000599393393 0.0459524690075879 NA NA NA 0.256367194726395 84.2933747183766 a628 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 6 37 -1.38629436111989 0.693147180559945 -1.5079263335963 -2.33606544477443 0.82813911117813 1.29348152093091 0.848569978372665 0.90557404550621 0.640240388267876 0.975923179330814 0.0460227590638539 NA NA NA 0.182637388342523 84.2933747183766 a629 gain_cnaBRCA48 282 EKB-569 EGFR 5 42 0.916290731874155 2.99573227355399 3.34609759751279 1.36758767284024 1.97850992467255 0.662626585406133 2.12618336765966 0.970295250108369 2.98585955989057 0.930545292925673 0.0461168589849984 NA NA NA 0.0003206714096388 84.2933747183766 a630 gain_cnaBRCA15 156 AZD6482 PI3Kbeta 22 25 1.63315443905142 NA 2.50250527591378 1.65801778485823 0.844487491055556 1.28566952451405 1.50834009828919 0.599431618050399 0.656846471782671 0.559878698453619 0.0461612839263324 NA NA NA 0.0440443587504778 84.2933747183766 a631 gain_cnaBRCA10_(MDM2,NUP107) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 4 43 0.940007258491471 NA 3.073061156099 1.7784817292855 1.2945794268135 0.542497847136771 1.24184603122345 1.07177243896562 2.38633099402351 1.04246371471518 0.0461873022066149 NA NA NA 0.00665837517653353 84.2933747183766 a632 BRCA2_mut 176 IPA-3 PAK1, PAK2, PAK3 6 41 3.46573590279973 NA 3.35977837719851 4.66323863138978 -1.30346025419127 1.76696998177886 1.41085857888002 0.8960104443963 0.737681040217239 0.923877328106117 0.0462287058393215 NA NA NA 0.13495242467045 84.2933747183766 a633 gain_cnaBRCA63 204 Tipifarnib Farnesyl-transferase (FNTA) 6 42 2.77258872223978 NA 2.76243914303746 1.45676758242473 1.30567156061273 2.62351418873959 1.24636756611112 0.894061968833325 0.497680388471621 1.04758146482153 0.0462367265615121 NA NA NA 0.280817685351461 84.2933747183766 a634 gain_cnaBRCA64_(SDHC) 172 Embelin XIAP 8 40 3.46573590279973 NA 3.61024296315067 2.86962602312579 0.740616940024878 1.37162975822554 0.830746240611655 0.79338056087639 0.539953974885323 0.89150802473639 0.0462421856882846 NA NA NA 0.178419923748053 84.2933747183766 a635 gain_cnaBRCA31 211 TL-2-105 CRAF 16 33 2.32630161961136 1.63315443905142 3.46656884737561 4.12136459186226 -0.654795744486644 0.939039691115112 1.09901141921848 0.623255054048227 0.697303586506628 0.595804313800743 0.0463843894769414 NA NA NA 0.0376425175228451 84.2933747183766 a636 gain_cnaBRCA47_(EGFR) 281 CH5424802 ALK 7 41 1.63315443905142 NA 2.84077758371319 3.7006355844946 -0.859858000781408 1.07780194015439 1.01951115313339 0.837006152465806 0.797788507096435 0.843402250322324 0.0464285924395428 NA NA NA 0.0851250852126972 84.2933747183766 a637 loss_cnaBRCA33 1001 AICAR AAPK1 (AMPK) agonist 5 40 7.60090245954208 NA 6.5898473192012 7.88206279276204 -1.29221547356084 1.1940851698307 1.34154767710322 0.9726722982681 1.0821803219816 0.963227394460627 0.0464351138529244 NA NA NA 0.0709156960392672 84.2933747183766 a638 gain_cnaBRCA14_(RAD21) 1375 Temozolomide DNA akylating agent 20 26 3.40119738166216 NA 6.131667180603 5.72201728527311 0.409649895329892 0.74005724388645 0.615743194424624 0.60937106601434 0.553538119806238 0.665293419463102 0.0464726130610716 NA NA NA 0.0529755841420721 84.2933747183766 a639 gain_cnaBRCA16 1192 GSK269962A ROCK1, ROCK2 16 30 1.6094379124341 NA 3.25088339607 2.35704243386694 0.893840962203061 1.63703356996945 1.27613432512225 0.634115255437318 0.546012603895313 0.700428587027807 0.0465182368469148 NA NA NA 0.069323406384007 84.2933747183766 a640 gain_cnaBRCA30_(CRNKL1,FOXA2) 1004 Vinblastine Microtubules 5 40 -2.30258509299405 NA -2.38968464146452 -3.5887948199235 1.19911017845898 1.31146539749288 1.22682763260629 0.970982154926844 0.914328491435086 0.977407214012268 0.0467993028351003 NA NA NA 0.110889688123682 84.5443711659381 a641 loss_cnaBRCA57 286 KIN001-236 TIE2 5 44 2.32630161961136 NA 5.18091853735572 4.46728415613099 0.713634381224733 0.495812949341376 0.759342994343518 0.963622285731004 1.43932178893815 0.939805050603907 0.0468027825523502 NA NA NA 0.0269463551601592 84.5443711659381 a642 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 283 GSK2126458 PI3K, MTOR 7 41 -2.05572501506252 0.0237165266173161 -4.17983663904188 -2.86337372973285 -1.31646290930904 1.13565847652188 1.63244847991362 0.835026279293529 1.15920669508046 0.806434583086322 0.0469264273963459 NA NA NA 0.0234747971426456 84.6356857978643 a643 gain_cnaBRCA30_(CRNKL1,FOXA2) 163 JQ1 BRD4 5 42 0.940007258491471 NA 1.52869822588703 0.171537996810167 1.35716022907686 1.54881738441583 1.39122136117585 0.965300795947769 0.876255808291271 0.975517100980829 0.0472003549230497 NA NA NA 0.122581193334023 84.7855610772872 a644 gain_cnaBRCA62 1495 AZD-2281 PARP1, PARP2 7 38 2.30258509299405 NA 4.7699144231363 3.85662387897461 0.913290544161689 1.39558452904842 1.02895300975561 0.839763990901312 0.654414351228455 0.88759208195388 0.047346725096202 NA NA NA 0.141296558484511 84.7855610772872 a645 TP53_mut 253 XMD14-99 EPHB3, CAMK1 37 11 2.32630161961136 NA 5.05272665531003 4.53072746220287 0.521999193107168 0.662604996005455 0.989757158667121 0.699702259568354 0.787798456477183 0.527401280744592 0.0473798394010226 NA NA NA 0.124716085489781 84.7855610772872 a646 gain_cnaBRCA58_(CCND1) 269 NSC-207895 MDM4 10 39 2.99573227355399 NA 5.26219162089003 4.43516054785523 0.827031073034792 0.871749171472795 1.20341206551093 0.720819768656593 0.948703021578498 0.68723847527959 0.0476615931316406 NA NA NA 0.0237728283968007 84.7855610772872 a647 gain_cnaBRCA31 1261 rTRAIL TR10A (DR4), TR10B (DR5) 15 32 -2.30258509299405 NA 0.293154790137606 -0.343931098458218 0.637085888595823 0.984361537930625 1.00724075156395 0.636971960050364 0.647207214063989 0.632506069285438 0.0477044380931029 NA NA NA 0.0495055738455069 84.7855610772872 a648 gain_cnaBRCA12_(TERT) 305 TPCA-1 IKK 9 40 2.99573227355399 NA 3.36161134520705 4.36208724526014 -1.00047590005309 1.57342993691866 1.27913537342994 0.750082262322137 0.635856657216261 0.782150131123624 0.0477101477076096 NA NA NA 0.103996474091528 84.7855610772872 a649 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 6 41 -2.30258509299405 NA 0.635590836661912 -0.254195568745618 0.889786405407531 0.81676029144764 1.02080676392427 0.889614974937893 1.08940948124505 0.871650185767717 0.0477394111290165 NA NA NA 0.0446668638999679 84.7855610772872 a650 ASH1L_mut 157 JNK-9L JNK 3 44 1.63315443905142 NA -1.10163670088113 0.134763456828774 -1.2364001577099 0.419447746311917 1.03758730193447 1.21440108951634 2.94768578108051 1.19161072557921 0.0477494822888272 NA NA NA 0.0128653086093771 84.7855610772872 a651 gain_cnaBRCA58_(CCND1) 230 GSK429286A ROCK2 10 39 2.99573227355399 2.32630161961136 5.90203033301745 5.27818903550216 0.623841297515291 0.498569262758971 0.932569615184328 0.719990353537126 1.25126305232515 0.668948770534396 0.0479075317088919 NA NA NA 0.00779703600836445 84.7855610772872 a652 BRCA1_mut 1009 ATRA Retinoic acid and retinoid X receptor agonist 4 41 2.30258509299405 NA 5.18854936274449 4.00035345781424 1.18819590493025 0.49156099444492 1.14746054184408 1.06631647318965 2.41718915527866 1.03550044781558 0.047977731358946 NA NA NA 0.00603380988098414 84.7855610772872 a653 gain_cnaBRCA31 222 BX-912 PDPK1 (PDK1) 16 33 2.32630161961136 NA 4.49112370278438 3.58931148391123 0.901812218873151 1.1768190480464 1.57596929543637 0.617475995143519 0.76631341102969 0.572227023384646 0.0483631407270436 NA NA NA 0.0307793906347155 84.7855610772872 a654 CDH1_mut 304 SB52334 ALK5 4 45 2.99573227355399 NA 3.10759038832514 4.40805186866476 -1.30046148033962 0.916667572007488 1.24874718167089 1.05708658655226 1.41868385012424 1.04141294525248 0.0484574921971052 NA NA NA 0.0573273743282025 84.7855610772872 a655 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1006 Cytarabine DNA synthesis 6 39 0.693147180559945 NA 2.34445023161514 1.03377681989841 1.31067341171673 1.88157298792565 1.40911648387116 0.890484257358336 0.69658387961962 0.930138442576455 0.0485071228245557 NA NA NA 0.153608901026574 84.7855610772872 a656 gain_cnaBRCA30_(CRNKL1,FOXA2) 155 AP-24534 ABL 5 42 -0.669430653942629 NA 2.3833773323685 1.33369100240749 1.04968632996101 0.736897291242223 1.12348301563334 0.958913399419777 1.42446761907823 0.934314373563772 0.0486182290029875 NA NA NA 0.0280287900592637 84.7855610772872 a657 gain_cnaBRCA31 1009 ATRA Retinoic acid and retinoid X receptor agonist 14 31 2.30258509299405 NA 3.6041739790206 4.33258882306688 -0.728414844046283 1.32346304654988 1.01076455915367 0.653526002916036 0.550385479930986 0.720657286060955 0.0486192291545801 NA NA NA 0.0817576808960477 84.7855610772872 a658 gain_cnaBRCA48 302 PI-103 PI3Ka, PRKDC (DNAPK) 5 43 2.32630161961136 NA 2.66300069453156 0.949995073924876 1.71300562060668 1.56488147830584 1.80990990668386 0.957021058612445 1.09465518274343 0.946459055382086 0.0486465124786132 NA NA NA 0.0685531417710332 84.7855610772872 a659 PIK3CA_mut 223 ZSTK474 PI3K 17 32 1.63315443905142 2.32630161961136 0.357488979288434 1.20710148304346 -0.849612503755024 1.45922021184487 1.36649270487127 0.607408481397712 0.582237346261036 0.621746827280034 0.0486893817875713 NA NA NA 0.0563368633622967 84.7855610772872 a660 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1021 Axitinib PDGFR, KIT, VEGFR 6 39 0.693147180559945 NA 3.33118904786519 2.32868460104713 1.00250444681806 1.20201599320165 1.11699073388246 0.889370350064371 0.834019224775726 0.897504711908873 0.0487765315292129 NA NA NA 0.100306574438839 84.7855610772872 a661 gain_cnaBRCA63 1494 SN-38 TOP1 6 42 -2.99573227355399 NA -2.04734114770074 -3.48328099024114 1.4359398425404 2.01745114710433 1.57095769927673 0.883415218800786 0.711759412167885 0.91405379228321 0.0487836260973884 NA NA NA 0.146305365666671 84.7855610772872 a662 loss_cnaBRCA28_(GPS2) 1527 GDC0941 (rescreen) PI3K 4 41 1.38629436111989 NA 2.05792936893082 0.875555985015595 1.18237338391522 0.96347370233377 1.12395815597691 1.06184125675464 1.22719839789215 1.05197277819256 0.0488803955846054 NA NA NA 0.085058748997908 84.7855610772872 a663 MLL3_mut 1024 CEP-701 FLT3, JAK2, NTRK1, RET 3 42 0.693147180559945 NA 2.18887136384667 0.513904462249208 1.67496690159746 1.61549513037221 1.37046227707659 1.21126693784836 1.03681333982824 1.22219117564507 0.0489084327009776 NA NA NA 0.209881265031995 84.7855610772872 a664 gain_cnaBRCA63 229 LY317615 PRKCB (PKCbeta) 7 42 2.99573227355399 2.32630161961136 2.25537163810769 3.54245164432197 -1.28708000621428 1.41001275831222 1.58016651172038 0.825327007284869 0.912814439888403 0.814521758730978 0.0489290064020212 NA NA NA 0.0566309623051019 84.7855610772872 a665 loss_cnaBRCA57 330 XMD13-2 RIPK 5 43 2.32630161961136 NA 4.72652082192029 3.60410268879173 1.12241813312856 0.802012577048793 1.20417557326022 0.955506958766466 1.39950190963187 0.932105050171125 0.0489891103150854 NA NA NA 0.0300287895080999 84.7855610772872 a666 gain_cnaBRCA27_(CLTC,PPM1D) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 10 35 0.693147180559945 NA 1.40693570233703 0.40232127093247 1.00461443140456 1.39317323307335 1.38013022820089 0.726470445598679 0.721097999556288 0.727912780168693 0.0489946032181793 NA NA NA 0.0628705241213343 84.7855610772872 a667 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 15 30 2.30258509299405 NA 3.71251278035755 2.90904407714908 0.803468703208467 0.996815845747331 1.36139869061352 0.64052772170452 0.806035243757679 0.590178842353949 0.0490482895998963 NA NA NA 0.0308214466542106 84.7855610772872 a668 gain_cnaBRCA31 156 AZD6482 PI3Kbeta 16 31 1.63315443905142 NA 2.63243321854612 1.75440739338132 0.878025825164794 1.1037998264411 1.54108325852646 0.622507287901824 0.795457477100488 0.569745872136941 0.0491181823897419 NA NA NA 0.0302502478977183 84.7855610772872 a669 loss_cnaBRCA18 272 AR-42 HDAC 16 33 1.63315443905142 NA -0.470697310282304 0.43901876847359 -0.909716078755894 0.977997114665006 1.66211459911997 0.615263858170413 0.930182783890421 0.547324522170468 0.0491397218540061 NA NA NA 0.0205158320828552 84.7855610772872 a670 gain_cnaBRCA10_(MDM2,NUP107) 167 OSU-03012 PDPK1 (PDK1) 4 44 2.77258872223978 NA 3.35401749990805 2.14743007555488 1.20658742435317 1.00423317023901 1.15245652996722 1.05528521353383 1.20150126495623 1.04697000969528 0.0491525189204961 NA NA NA 0.0899423167344604 84.7855610772872 a671 loss_cnaBRCA28_(GPS2) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 3 40 0.693147180559945 NA -0.131675695935795 1.81796872546786 -1.94964442140366 2.90072576594387 1.51083132699161 1.21339268937551 0.672122971531319 1.2904447945793 0.0491962813275835 NA NA NA 0.364251069836116 84.7855610772872 a672 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 5 41 1.63315443905142 NA 0.625934970481101 2.0964315595959 -1.4704965891148 1.58369652165594 1.53010156878727 0.957946305112404 0.928521701605576 0.961045082961577 0.0492537878609733 NA NA NA 0.106800719364668 84.7855610772872 a673 gain_cnaBRCA30_(CRNKL1,FOXA2) 177 GSK-650394 SGK3 5 42 2.77258872223978 NA 5.41243313041847 3.8480109160925 1.56442221432597 1.65893504131423 1.63423146727084 0.955989758333216 0.943028012167745 0.957283130117764 0.049279456434074 NA NA NA 0.102727115347058 84.7855610772872 a674 gain_cnaBRCA48 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 5 40 -0.669430653942629 NA -5.4823086791008 -3.23667684161462 -2.24563183748618 1.43525112254203 2.41585201830102 0.958844816664203 1.56462642823707 0.929540311440703 0.0494884499009704 NA NA NA 0.0189808341807469 84.9026733702447 a675 gain_cnaBRCA61_(NOTCH2) 200 LAQ824 HDAC 3 45 0.0237165266173161 NA -1.14840926645994 -2.78687128611332 1.63846201965339 1.63075635129344 1.34905296889651 1.20252982667229 1.00472521131304 1.21452756669266 0.0495858128559524 NA NA NA 0.220149422375701 84.9026733702447 a676 loss_cnaBRCA57 299 OSI-027 MTORC1/2 5 43 2.99573227355399 NA 2.90414788568635 1.0788325494379 1.82531533624845 1.58110217717464 1.94611321696359 0.952106321142728 1.15445754398378 0.93792864687307 0.04976620983905 NA NA NA 0.0584012818403913 84.9026733702447 a677 gain_cnaBRCA31 165 DMOG Prolyl-4-Hydroxylase 15 31 8.29404964010203 NA 8.20300266149451 7.26367956968043 0.939323091814079 1.74486652917612 1.3390525253376 0.634552421144593 0.538335211380095 0.701483380255946 0.0497676665547565 NA NA NA 0.0792413642358025 84.9026733702447 a678 gain_cnaBRCA10_(MDM2,NUP107) 136 Mitomycin C DNA crosslinker 4 44 2.77258872223978 NA 1.24321049329604 -0.259533992899839 1.50274448619588 0.799281034572307 1.46195106237003 1.05224097983905 1.88012028460051 1.02790341268997 0.0497829238773794 NA NA NA 0.021210428289466 84.9026733702447 a679 loss_cnaBRCA36_(FAT1,IRF2) 1019 Bosutinib SRC, ABL, TEC 8 37 0.693147180559945 NA 2.08015822454632 2.78853157790753 -0.708373353361204 1.00984259821716 0.877040030889552 0.787085500408197 0.701469075093301 0.807686454907566 0.0497874732001003 NA NA NA 0.0974795995148732 84.9026733702447 a680 loss_cnaBRCA38 1011 ABT-263 BCL2, BCL2L1, BCL2L2 3 40 0.693147180559945 NA -0.126447096519321 1.81757658051163 -1.94402367703095 2.90869939634464 1.5105634160312 1.20954562651763 0.668348086940165 1.28695270678447 0.0498863388125853 NA NA NA 0.366408130480302 84.9072081986513 a681 loss_cnaBRCA17 1133 JNJ-26854165 MDM2 9 34 2.30258509299405 NA 3.47098018888888 2.83588990813083 0.63509028075805 0.802925322458533 0.847553389074079 0.756932228311819 0.790970546069493 0.749321858593312 0.0500348311555531 NA NA NA 0.0571073349672536 84.9072081986513 a682 gain_cnaBRCA64_(SDHC) 301 PHA-793887 CDK-pan 8 40 2.32630161961136 NA 1.89235009641708 3.1282538680925 -1.23590377167542 1.72456222347914 1.55967414453537 0.779321203199376 0.716647827981584 0.792411527757677 0.0500761195005121 NA NA NA 0.0914342117979274 84.9072081986513 a683 gain_cnaBRCA58_(CCND1) 134 Etoposide TOP2 9 38 2.77258872223978 NA 3.73466598058392 2.17925752446971 1.5554084561142 1.19926333178777 2.22957008951091 0.746367338583564 1.29696991051624 0.69762707323339 0.0500834469295093 NA NA NA 0.0083282874409066 84.9072081986513 a684 gain_cnaBRCA62 1038 NU-7441 PRKDC (DNAPK) 7 36 0.693147180559945 NA 3.52689264522602 2.76958186548202 0.757310779744002 1.02095995923806 0.888156212338608 0.833304930966811 0.741763448107389 0.852677456086158 0.0502433227658071 NA NA NA 0.104894933038797 84.96644390448 a685 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 152 CP466722 ATM 15 34 2.77258872223978 NA 2.28683868511002 2.92571664695689 -0.638877961846876 0.540427452579373 1.17285640815243 0.622640033273008 1.18217155475284 0.544719675320939 0.0503287447246686 NA NA NA 0.0121274949304693 84.96644390448 a686 loss_cnaBRCA38 275 I-BET BRD2, BRD3, BRD4 4 45 2.99573227355399 NA 2.77453681092503 4.15133254807905 -1.37679573715402 0.496122573751921 1.3520348693263 1.04765855998192 2.77511205898578 1.01831377902262 0.050413253866823 NA NA NA 0.00256671959102226 84.96644390448 a687 gain_cnaBRCA19 225 Genentech Cpd 10 AURKA, AURKB 4 45 2.32630161961136 NA 1.51735197829881 3.15146002187322 -1.63410804357442 1.57069467591787 1.55950129931762 1.04735868069664 1.04037281632695 1.04784012959107 0.0504765658140741 NA NA NA 0.125730711514565 84.96644390448 a688 loss_cnaBRCA33 203 BMS-345541 IKBKB 6 43 2.77258872223978 NA 2.78443919662175 3.63668930108611 -0.852250104464353 0.679481263392717 1.00419710801594 0.874274924839578 1.25426579124343 0.84868806896706 0.0506161778651155 NA NA NA 0.0262906376196135 84.96644390448 a689 loss_cnaBRCA60 157 JNK-9L JNK 3 44 1.63315443905142 NA 1.19877177738614 -0.0220825757803575 1.2208543531665 1.3382049145017 1.00198444647367 1.19775524487073 0.912307479920664 1.21843643128703 0.0507494016522178 NA NA NA 0.252294106591283 84.96644390448 a690 loss_cnaBRCA33 1038 NU-7441 PRKDC (DNAPK) 5 38 0.693147180559945 NA 2.12375208417161 2.99406408560729 -0.870312001435675 0.970461813631982 0.902099241742956 0.95744408804032 0.896801903187213 0.964763034002928 0.0507569581777474 NA NA NA 0.116367832805456 84.96644390448 a691 gain_cnaBRCA13_(FGFR1,WHSC1L1) 156 AZD6482 PI3Kbeta 10 37 1.63315443905142 NA 2.84810712559718 1.83849971447532 1.00960741112186 1.53704300449258 1.37812937561798 0.715351611544352 0.656850464281677 0.732592620826423 0.0507670712479761 NA NA NA 0.0820061036743384 84.96644390448 a692 gain_cnaBRCA64_(SDHC) 1030 KU-55933 ATM 7 35 2.30258509299405 NA 4.83790541181912 4.09917814369364 0.738727268125483 0.774335354305527 0.904889780292988 0.833276559197968 0.95401464496997 0.81637265025393 0.0509279601359107 NA NA NA 0.0503201349156987 84.96644390448 a693 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 35 NVP-TAE684 ALK 5 9 0.693147180559945 NA 2.59967119641657 1.31379429079077 1.2858769056258 0.818709833313391 1.16625100600646 1.20954980385338 1.57061373065686 1.10257303016524 0.0509283784362617 NA NA NA 0.0346162960215379 84.96644390448 a694 ARID1A_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 5 38 2.30258509299405 NA 2.87783051097249 3.93148487234304 -1.05365436137055 1.2383896859872 1.08581151518075 0.956452170310071 0.850826176358707 0.970384221054378 0.0509860569249416 NA NA NA 0.1314382385743 84.96644390448 a695 ARID1A_mut 219 AT-7519 CDK9 5 44 2.32630161961136 NA 3.15918333822864 1.50300245395012 1.65618088427852 0.721442501946966 1.81873235584405 0.945144670281006 2.29565194704909 0.910623753383385 0.0509989450847341 NA NA NA 0.00230340744833384 84.96644390448 a696 MLL3_mut 1149 TW 37 BCL2, BCL2L1 3 40 1.6094379124341 NA 1.20031713213001 -0.243086845390764 1.44340397752078 3.00938518584398 1.0243400178036 1.20289344438152 0.479634173887242 1.40910630497063 0.0510994210792575 NA NA NA 0.493832827222994 84.9843217800748 a697 gain_cnaBRCA31 329 QL-XI-92 DDR1 16 32 2.32630161961136 NA 4.62719309935684 4.06640609761056 0.560787001746274 0.900256713683882 0.921781636494566 0.613003705359869 0.622918988797666 0.608372937303118 0.0511947254550849 NA NA NA 0.0523608891404891 84.9843217800748 a698 ASH1L_mut 1033 Vismodegib SMO 3 42 2.30258509299405 NA 3.9163652403904 4.8200180932027 -0.903652852812299 0.863531137006094 0.748539299423896 1.19803910884313 1.04646238460527 1.20722165624141 0.0513172031543765 NA NA NA 0.206854701673449 84.9843217800748 a699 PTEN_mut 1038 NU-7441 PRKDC (DNAPK) 6 37 0.693147180559945 NA 2.20206371312513 3.00488684851849 -0.802823135393362 1.16878354792354 0.86708604656808 0.882947123123397 0.686887779024317 0.925886350692564 0.0514608629346611 NA NA NA 0.158680019169094 84.9843217800748 a700 gain_cnaBRCA30_(CRNKL1,FOXA2) 135 Gemcitabine DNA replication 5 42 0.0237165266173161 NA 1.98178485816388 -0.543915228294051 2.52570008645793 1.54137539169372 2.75405108477218 0.946427911165917 1.63860153734685 0.917085416615233 0.0514967572770294 NA NA NA 0.0154188284574348 84.9843217800748 a701 gain_cnaBRCA15 17 Cyclopamine SMO 6 7 2.77258872223978 NA 4.23093930590777 5.09395546740431 -0.863016161496539 0.969248511715051 0.376771152104631 1.21509370759956 0.890397200579098 2.29055795985377 0.0515000345123319 NA NA NA 0.0838099378503039 84.9843217800748 a702 loss_cnaBRCA33 1373 Dabrafenib BRAF 5 41 2.30258509299405 NA 2.88135975810706 4.37717807951402 -1.49581832140696 3.99370770544142 1.0693386065986 0.948030636820457 0.374543765275789 1.39882569672194 0.0515469588406298 NA NA NA 0.450498252292366 84.9843217800748 a703 gain_cnaBRCA58_(CCND1) 179 5-Fluorouracil DNA antimetabolite 10 39 3.46573590279973 NA 4.92344300987379 3.81533147733092 1.10811153254287 1.77577556580915 1.51102544893021 0.707971297508578 0.624015530947991 0.733350674753627 0.0515968375605774 NA NA NA 0.0939305315248811 84.9843217800748 a704 ARID1A_mut 170 Shikonin unknown 5 42 2.77258872223978 NA -0.964839810632555 0.118899413984886 -1.08373922461744 1.44668898967189 1.11239766413352 0.945615327907479 0.749116936918996 0.974237235082295 0.0516891064592385 NA NA NA 0.171669873906625 84.9997443088028 a705 gain_cnaBRCA47_(EGFR) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 6 40 0 NA -0.859407589741957 0.880108555695948 -1.73951614543791 1.13950903669596 2.07143614028538 0.875156276572859 1.52654879375216 0.839763346601772 0.051808957735456 NA NA NA 0.0110694661945647 84.9997443088028 a706 PIK3CA_mut 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 14 28 -1.38629436111989 0.693147180559945 0.410941053774327 -0.658827351535431 1.06976840530976 1.2448168361018 1.78701509127665 0.656019401887753 0.859378162541396 0.598634231200317 0.0518552847864836 NA NA NA 0.0302960171054315 84.9997443088028 a707 loss_cnaBRCA36_(FAT1,IRF2) 304 SB52334 ALK5 9 40 2.99573227355399 NA 5.041836446584 4.13540419059897 0.906432255985035 0.802033971301728 1.30249477975454 0.735887203538516 1.13016691115199 0.695920068221583 0.0518998352416647 NA NA NA 0.0146501938636187 84.9997443088028 a708 TP53_mut 56 WH-4-023 SRC family, ABL 9 3 1.63315443905142 NA 3.57363665529636 2.17222726723228 1.40140938806408 0.911605618726422 1.1058654492984 1.46955468466707 1.53729788329075 1.26725126366248 0.0520579158004737 NA NA NA 0.142699389945838 85.0205471631272 a709 gain_cnaBRCA58_(CCND1) 266 Zibotentan, ZD4054 Endothelin A Receptor 10 39 2.99573227355399 NA 6.00992506028383 5.67335074968739 0.336574310596442 0.321754168173748 0.50613549267306 0.706517257726229 1.04606045201158 0.664988556362422 0.0520593902225211 NA NA NA 0.0168247012600894 85.0205471631272 a710 gain_cnaBRCA14_(RAD21) 63 BMS-509744 ITK 6 6 2.32630161961136 NA 3.01184122074129 4.18048948472585 -1.16864826398456 0.941797066137353 0.89816981736677 1.26993578227467 1.24087057180758 1.30114399458531 0.0524771790955452 NA NA NA 0.0525355865748003 85.5821488376504 a711 gain_cnaBRCA19 235 QL-XII-47 BTK, BMX 4 45 2.32630161961136 NA 0.321427524660967 1.83133265661259 -1.50990513195163 1.48468004363736 1.45333986725219 1.03747845621563 1.01699025215727 1.03892087871118 0.0526013191097575 NA NA NA 0.131971479593797 85.6111814565898 a712 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1020 Lenalidomide TNFA 17 28 1.6094379124341 NA 4.51594230344879 4.09613131432704 0.419810989121753 0.714468616759922 0.667114697940066 0.612757900297656 0.58758492573904 0.629293568884116 0.0526428544754227 NA NA NA 0.0588436596912225 85.6111814565898 a713 gain_cnaBRCA16 260 NG-25 MAP3K7 (TAK1) 16 33 2.32630161961136 NA 3.71530848115381 2.96254215547364 0.752766325680174 1.48164305697966 1.11462420237774 0.605320775696143 0.508061858849252 0.675354369727802 0.0527650487798462 NA NA NA 0.0846610879777695 85.664495586039 a714 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 133 Doxorubicin DNA intercalating 9 39 0.0237165266173161 NA 0.0290605813866793 -1.27519242159255 1.30425300297923 1.34859224427772 1.85163646262297 0.735028712129752 0.967121832795176 0.704378548007022 0.0528236029436323 NA NA NA 0.0278113247200064 85.664495586039 a715 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1054 PD-0332991 CDK4, CDK6 14 28 1.38629436111989 0.693147180559945 3.49643541161384 2.57613940166666 0.920296009947177 1.14833161223444 1.51987770394575 0.652735653290045 0.801420077739085 0.605506619090471 0.0529844353815916 NA NA NA 0.0356576104189742 85.7693040840107 a716 loss_cnaBRCA17 302 PI-103 PI3Ka, PRKDC (DNAPK) 10 38 2.32630161961136 NA 0.127073975939765 1.39194873400078 -1.26487475806102 1.0961201550188 1.92453770289331 0.70551712954139 1.15395629965341 0.657235634386082 0.0531166898954589 NA NA NA 0.0118338861750235 85.7693040840107 a717 gain_cnaBRCA27_(CLTC,PPM1D) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 10 33 1.6094379124341 NA 3.6258452389315 2.63829644480195 0.987548794129558 1.12578319269774 1.43671848451382 0.718476946340357 0.877210461601463 0.687364159906206 0.0532444294488396 NA NA NA 0.0351878971254396 85.7693040840107 a718 gain_cnaBRCA31 1017 Olaparib PARP1, PARP2 14 31 1.6094379124341 NA 4.45216235743548 3.90335939992593 0.548802957509543 0.754675907015149 0.899302822307354 0.639516559693927 0.727203495445001 0.610253792044676 0.0534261363039657 NA NA NA 0.0421189035807964 85.7693040840107 a719 loss_cnaBRCA33 258 STF-62247 stimulates autophagy 6 43 2.32630161961136 NA 3.92595261700064 4.72919968980744 -0.803247072806793 0.870184002995778 0.937303763082598 0.863341187673605 0.923077268763225 0.856976259398639 0.0534543572449758 NA NA NA 0.0757245513291553 85.7693040840107 a720 gain_cnaBRCA27_(CLTC,PPM1D) 1268 XAV 939 TNKS1 (tankyrase-1) 10 37 1.6094379124341 NA 4.16655113211138 3.52492688945851 0.641624242652871 0.936014053094998 0.900492417545265 0.706861978124687 0.685485693864632 0.712525980398517 0.0534572624788247 NA NA NA 0.0731879528761403 85.7693040840107 a721 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 282 EKB-569 EGFR 6 41 0.916290731874155 2.99573227355399 3.12429659497839 1.35179001651179 1.7725065784666 0.60363682741075 2.15828294648076 0.866847720011588 2.936379123967 0.821257741649121 0.0534705095561913 NA NA NA 0.000208827896445323 85.7693040840107 a722 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 164 JQ12 HDAC 7 40 1.63315443905142 NA 2.67476536506092 1.38592878740075 1.28883657766016 1.17300837102799 1.64067161235405 0.812478369619559 1.09874456951289 0.785554262020131 0.0534808166064908 NA NA NA 0.0297204877035283 85.7693040840107 a723 loss_cnaBRCA33 275 I-BET BRD2, BRD3, BRD4 6 43 2.99573227355399 NA 3.04369550165313 4.17781253249624 -1.13411703084311 0.879880778569694 1.35831077221566 0.861981369455101 1.28894397794062 0.834946651415535 0.0538167556677611 NA NA NA 0.0235898486118116 86.1886879497933 a724 MLL3_mut 1031 Elesclomol HSP70 3 41 -1.6094379124341 NA -1.07542041271277 -3.11676141138962 2.04134099867685 1.83531453828345 1.71544052106709 1.18590355958626 1.11225675822636 1.18998063389982 0.0539570110071972 NA NA NA 0.187777590708312 86.2529587939082 a725 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 52 GNF-2 ABL [T315I] 3 9 0.246860077931526 NA 3.01250372505524 2.31161582042924 0.700887904626001 0.211977360105149 0.528341123916259 1.4541920271823 3.30642812175004 1.32658215099889 0.0541275036900651 NA NA NA 0.00956767423253677 86.2529587939082 a726 gain_cnaBRCA30_(CRNKL1,FOXA2) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 5 43 2.77258872223978 NA 0.702545942937827 -0.568977567175225 1.27152351011305 1.48678106911456 1.3494336770527 0.933620969113473 0.855219061183164 0.942264545294428 0.0541797018487336 NA NA NA 0.12972901981955 86.2529587939082 a727 TP53_mut 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 35 10 2.30258509299405 NA 1.53310079114989 0.778105299963991 0.754995491185899 0.908616904634688 1.51271100023059 0.709695935736746 0.830928290388177 0.499100945964439 0.0542138510773149 NA NA NA 0.161259968194031 86.2529587939082 a728 ASH1L_mut 1259 BMN-673 PARP1 3 43 2.30258509299405 NA 1.64537724459071 3.42136321230398 -1.77598596771327 3.52286961314881 1.33357930914834 1.18092043118869 0.504130485296576 1.33174379321127 0.0542597334898649 NA NA NA 0.474972857930724 86.2529587939082 a729 ASH1L_mut 140 Vinorelbine Microtubules 3 44 -2.74887219562247 NA -5.35648818514496 -3.48004408826862 -1.87644409687635 0.572774839762051 1.62331502694084 1.17910115218297 3.27605887447131 1.15593342372524 0.0543038319032378 NA NA NA 0.00694651080164948 86.2529587939082 a730 PTEN_mut 1375 Temozolomide DNA akylating agent 8 38 3.40119738166216 NA 5.47229637638258 5.99019531626579 -0.51789893988321 0.539805840240493 0.696888965481353 0.767996659275196 0.959417074206676 0.743158473639324 0.0546431373699129 NA NA NA 0.0369842326040835 86.4882434776709 a731 loss_cnaBRCA57 308 XL-880 MET 5 44 1.63315443905142 NA 3.14502011915132 1.70030978250749 1.44471033664383 1.73097634732001 1.5357752179028 0.930065024989933 0.834621650885413 0.940704290447316 0.0546606890031396 NA NA NA 0.136957517890195 86.4882434776709 a732 loss_cnaBRCA17 274 PXD101, Belinostat HDAC 11 37 2.99573227355399 NA -0.0837437502728642 0.896036266469274 -0.979780016742138 0.903894585844967 1.56496759521952 0.677028726036614 1.08395385046613 0.626070482056662 0.054705871866526 NA NA NA 0.0139799430444852 86.4882434776709 a733 loss_cnaBRCA60 150 Bicalutamide ANDR (androgen receptor) 3 45 0.0237165266173161 NA 2.09791902882843 2.80689899109432 -0.708979962265898 0.811990292189959 0.591990426865732 1.17531330280091 0.873138471093985 1.1976206541372 0.0547507405381577 NA NA NA 0.267515548311855 86.4882434776709 a734 loss_cnaBRCA57 1248 FK866 NAMPT 5 39 0 NA 1.52523492387102 -0.929672638858049 2.45490756272907 0.91348169862206 2.73600491475973 0.937816709890367 2.68741844136798 0.897259924309987 0.0549498990575923 NA NA NA 0.000817304163681033 86.6317532326502 a735 loss_cnaBRCA57 223 ZSTK474 PI3K 5 44 1.63315443905142 2.32630161961136 2.08142015567808 0.779487711975083 1.30193244370299 1.09795543432248 1.4267959530242 0.928747069755211 1.1857789514985 0.912486779166602 0.0549912243077968 NA NA NA 0.053681373357909 86.6317532326502 a736 loss_cnaBRCA33 1050 ZM-447439 AURKB 5 34 1.38629436111989 0.693147180559945 1.84332218665726 3.04154200727993 -1.19821982062267 1.10305184151763 1.28240591500918 0.947776089144604 1.08627697767505 0.934353005237108 0.0553202014151051 NA NA NA 0.0705128473203936 86.9136266015685 a737 gain_cnaBRCA63 190 Bleomycin DNA damage 6 42 4.15888308335967 NA 4.07199665824702 1.79359951319833 2.27839714504869 2.24540644151337 2.70073220829765 0.858145102041175 1.0146925309046 0.843622014077741 0.0553202718761171 NA NA NA 0.0568662451364487 86.9136266015685 a738 gain_cnaBRCA61_(NOTCH2) 175 PAC-1 CASP3 agonist 3 45 0.940007258491471 NA 3.70143927637454 2.31471130215568 1.38672797421887 0.199768546656473 1.20908446895929 1.17197387878412 6.94167323849794 1.14692398241827 0.0554153320494283 NA NA NA 3.60446804538074e-06 86.9450040379851 a739 loss_cnaBRCA18 219 AT-7519 CDK9 16 33 2.32630161961136 NA 0.966311335499932 2.01415282718029 -1.04784149168036 1.6917695820805 1.78421483478665 0.596979006375628 0.619376008872169 0.587284373636346 0.0559822652905127 NA NA NA 0.05460164895053 87.3741842958262 a740 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 328 SNX-2112 HSP90 6 42 0.940007258491471 NA -1.06106012592503 0.628425682857167 -1.68948580878219 1.48138899090015 2.0264526074641 0.85564872284593 1.14047412203029 0.833715924349405 0.0560051924651402 NA NA NA 0.0381598907231544 87.3741842958262 a741 gain_cnaBRCA27_(CLTC,PPM1D) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 9 34 1.6094379124341 NA 3.79170395118724 2.72201906260457 1.06968488858267 0.726860945498641 1.57757151866778 0.737063032990787 1.47164996992491 0.678057936470604 0.0560691625838392 NA NA NA 0.0062597025452872 87.3741842958262 a742 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 15 27 -1.38629436111989 0.693147180559945 0.362973325365941 -0.671799665579281 1.03477299094522 1.39153865233954 1.74987326409916 0.633499833835386 0.743617857258578 0.591341677237365 0.0561222916301054 NA NA NA 0.042905360063919 87.3741842958262 a743 loss_cnaBRCA18 287 KIN001-244 PDPK1 (PDK1) 16 33 2.99573227355399 NA 3.11117153697449 3.65601368058819 -0.544842143613699 0.833311875293681 0.948386282839108 0.596605312365942 0.653827408161778 0.574493909783942 0.05613025407428 NA NA NA 0.0482730863097478 87.3741842958262 a744 gain_cnaBRCA62 228 KIN001-102 AKT1 10 39 2.32630161961136 NA 1.19101464215148 2.13670076362848 -0.945686121477001 1.10921479550039 1.41612338729431 0.693972080775488 0.852572581355069 0.667799239785072 0.0562009622854191 NA NA NA 0.0366279892608869 87.3741842958262 a745 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 136 Mitomycin C DNA crosslinker 7 41 2.77258872223978 NA 0.845065602027228 -0.301514949478032 1.14658055150526 1.17372800936072 1.46606947850261 0.801060572419515 0.976870742080826 0.782077908528823 0.0562170889544784 NA NA NA 0.0457450124542743 87.3741842958262 a746 gain_cnaBRCA19 268 YM155 BIRC5 (Survivin) 4 45 1.63315443905142 NA -5.04715694519191 -3.46654876257991 -1.580608182612 0.601220978622707 1.59251510727047 1.02085307449188 2.62899705567975 0.992523195162094 0.0563508748941674 NA NA NA 0.0035953918536743 87.4647158712553 a747 gain_cnaBRCA62 1203 QL-XII-61 BTK 3 20 2.30258509299405 NA 5.7508272751159 3.99636860251276 1.75445867260314 0.765218267108512 1.45605070574964 1.24875240900938 2.29275586850875 1.2049433894542 0.0566693418644875 NA NA NA 0.0269258915079794 87.7238381616177 a748 gain_cnaBRCA63 1203 QL-XII-61 BTK 3 20 2.30258509299405 NA 5.7508272751159 3.99636860251276 1.75445867260314 0.765218267108512 1.45605070574964 1.24875240900938 2.29275586850875 1.2049433894542 0.0566693418644875 NA NA NA 0.0269258915079794 87.7238381616177 a749 gain_cnaBRCA31 295 NVP-BHG712 EPHB4 16 33 2.32630161961136 NA 4.36377259311393 3.65540432949237 0.708368263621557 1.13818476798527 1.21457676489029 0.594903041123454 0.622366669759126 0.583222307636965 0.056808641676607 NA NA NA 0.0543544268404672 87.7736535405851 a750 gain_cnaBRCA30_(CRNKL1,FOXA2) 170 Shikonin unknown 5 42 2.77258872223978 NA 0.952095291788905 -0.109307145827193 1.0614024376161 0.982814685043441 1.16301331972483 0.924452657547117 1.07996192341101 0.912631368544624 0.0569218915330811 NA NA NA 0.071391223186174 87.7736535405851 a751 gain_cnaBRCA27_(CLTC,PPM1D) 1243 piperlongumine Increases ROS levels 10 37 2.30258509299405 NA 2.16302580550143 1.58787456921281 0.575151236288623 1.16026696540936 0.718318497691365 0.696435047782564 0.495705948230373 0.800691111445866 0.0569289349762323 NA NA NA 0.163937810716445 87.7736535405851 a752 loss_cnaBRCA28_(GPS2) 1031 Elesclomol HSP70 3 41 -1.6094379124341 NA -1.09909605856272 -3.11502904705914 2.01593298849642 0.286172299277266 1.7647279729323 1.16978930703059 7.0444728353782 1.14234772691154 0.0571570087752051 NA NA NA 3.46545778137909e-06 88.0081123149069 a753 gain_cnaBRCA31 301 PHA-793887 CDK-pan 16 32 2.32630161961136 NA 3.55469351830587 2.60605810006696 0.94863541823891 1.34956488395824 1.69395224692052 0.596674841836601 0.702919459090092 0.560013081811166 0.0574419239411365 NA NA NA 0.0423631258789864 88.1725323213064 a754 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1164 XMD8-92 MAP2K5 (ERK5) 5 21 2.30258509299405 NA 2.90326507331732 4.1181137280393 -1.21484865472198 1.32615702047877 1.20202108040654 0.992859803543471 0.916066978466393 1.0106716716741 0.0574890303583103 NA NA NA 0.112966131355577 88.1725323213064 a755 ARID1A_mut 1199 Tamoxifen ER 5 42 1.6094379124341 NA 3.10909910198451 3.95965487947296 -0.850555777488445 1.3906006126842 0.863170988616536 0.922163047620006 0.611646341681573 0.985385038081145 0.0575144543467797 NA NA NA 0.246415223778633 88.1725323213064 a756 TP53_mut 41 S-Trityl-L-cysteine KIF11 9 3 1.63315443905142 NA 1.72511306395274 -0.278755801429595 2.00386886538233 1.5545741779483 0.396115784167178 1.42960647399571 1.28901463423701 5.0587958003123 0.0576050724557904 NA NA NA 0.00544726528388911 88.1725323213064 a757 gain_cnaBRCA48 254 AC220 FLT3 5 43 0.0237165266173161 NA 2.92875872023181 2.14178552243052 0.786973197801285 0.41874161039755 0.885838839714394 0.919997935532555 1.87937663289334 0.888393195826699 0.05764453490563 NA NA NA 0.00775467924288674 88.1725323213064 a758 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 260 NG-25 MAP3K7 (TAK1) 6 43 2.32630161961136 NA 2.28193017594001 3.33761036682444 -1.05568019088443 0.713402404091625 1.29448195296758 0.847515750697652 1.47978221664199 0.815523297535589 0.0578047222796661 NA NA NA 0.0128079630060511 88.300907556234 a759 gain_cnaBRCA30_(CRNKL1,FOXA2) 206 Ruxolitinib JAK1, JAK2, TYK2 5 44 1.65632149833295 0.0237165266173161 4.89189747249431 4.31098351822143 0.580913954272877 0.860212555197222 0.607917352945477 0.917260021244399 0.675314433349197 0.955580477277439 0.0579456138010202 NA NA NA 0.208536730187969 88.3033482603438 a760 loss_cnaBRCA24 150 Bicalutamide ANDR (androgen receptor) 3 45 0.0237165266173161 NA 2.10617651063428 2.80634849230727 -0.700171981672989 0.822235020902237 0.592017756023474 1.1595034139133 0.851547263098441 1.18268746933534 0.057958843317956 NA NA NA 0.276329430826381 88.3033482603438 a761 loss_cnaBRCA23 1066 AZD6482 PI3Kbeta 3 40 1.6094379124341 NA 3.47268646100522 1.85427522625261 1.61841123475261 1.28547711283303 1.39292531415202 1.16610571226491 1.25899653801369 1.16187940466705 0.0582803593922228 NA NA NA 0.15162527796994 88.6765152959984 a762 gain_cnaBRCA14_(RAD21) 1495 AZD-2281 PARP1, PARP2 20 25 2.30258509299405 NA 4.35238140384398 3.7157392114444 0.636642192399581 1.24493355160485 0.953919966004618 0.582945995244044 0.511386484506649 0.667395814206597 0.0585625661535017 NA NA NA 0.0675651970199785 88.8466003163395 a763 gain_cnaBRCA14_(RAD21) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 19 24 1.6094379124341 NA 3.08310530742076 2.15902830247593 0.924077004944829 1.40696240503391 1.64870707410333 0.597244724205548 0.656788697152543 0.560485861593939 0.0586657545756495 NA NA NA 0.0542918378263587 88.8466003163395 a764 loss_cnaBRCA17 1373 Dabrafenib BRAF 9 37 2.30258509299405 NA 5.13244330264218 3.99132730613055 1.14111599651163 0.30798414605739 1.74263780913476 0.721432510476054 3.70511278297744 0.654821093935869 0.058673426717216 NA NA NA 0.000527879268427725 88.8466003163395 a765 loss_cnaBRCA33 301 PHA-793887 CDK-pan 6 42 2.32630161961136 NA 1.74479484102861 3.09048062973488 -1.34568578870627 1.52329337137434 1.59850105136015 0.84607795736383 0.883405530408219 0.841842291915442 0.0586990666223333 NA NA NA 0.0861561320017607 88.8466003163395 a766 BRCA2_mut 1495 AZD-2281 PARP1, PARP2 5 40 2.30258509299405 NA 3.10483607291499 4.11042319996036 -1.00558712704538 1.01874447519859 1.09946751438405 0.920690190492524 0.987084741587781 0.914612859306473 0.0588330610168355 NA NA NA 0.0916171806854222 88.9331610331512 a767 gain_cnaBRCA63 1059 AZD8055 MTORC1/2 5 38 0.693147180559945 NA 0.924223929860666 0.0259842604635686 0.898239669397098 0.853254362586372 0.984601148032506 0.923575166030682 1.05272203551866 0.912287855028423 0.0591040929867621 NA NA NA 0.0769842134286927 88.9585084703157 a768 loss_cnaBRCA33 293 MP470 PDGFR 6 42 2.99573227355399 NA 2.33629381034152 3.70234108477566 -1.36604727443414 1.38347975932675 1.64403289840428 0.844413959023763 0.987399537452509 0.830912371498187 0.0591785988002327 NA NA NA 0.0621639296558739 88.9585084703157 a769 loss_cnaBRCA36_(FAT1,IRF2) 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 3 11 1.38629436111989 NA 2.67670754591316 1.71436806152146 0.962339484391703 0.411833483553503 0.754535354468342 1.35728820586438 2.33671987058498 1.27540675025067 0.0592182406589409 NA NA NA 0.0250980916064336 88.9585084703157 a770 loss_cnaBRCA33 1261 rTRAIL TR10A (DR4), TR10B (DR5) 5 42 -2.30258509299405 NA -0.962301092400554 -0.0427849484903837 -0.91951614391017 0.778000061725794 1.02365072955124 0.915623558188978 1.18189726344039 0.898271370659093 0.0592361784341638 NA NA NA 0.0542880668405044 88.9585084703157 a771 gain_cnaBRCA30_(CRNKL1,FOXA2) 1230 IOX2 EGLN1 5 42 -2.30258509299405 NA 0.767396445398795 0.18780393456053 0.579592510838265 0.219213732587671 0.659689440008592 0.915526178500295 2.64396077744111 0.878583884608971 0.0592621472042899 NA NA NA 0.000884856933022799 88.9585084703157 a772 loss_cnaBRCA38 257 NPK76-II-72-1 PLK3 4 45 2.32630161961136 NA 2.05642067812114 3.60540826319711 -1.54898758507597 2.28396386702932 1.47193072739501 1.00803699411015 0.678201440678084 1.05235087239284 0.0593959718130378 NA NA NA 0.269155958693187 88.9585084703157 a773 loss_cnaBRCA57 175 PAC-1 CASP3 agonist 5 43 0.940007258491471 NA 3.37057446524092 2.28868497906801 1.0818894861729 0.957169033558598 1.20419660319484 0.913170018144298 1.13030138694585 0.89843260087477 0.0594515763831467 NA NA NA 0.0623672473046733 88.9585084703157 a774 gain_cnaBRCA9_(KRAS) 1019 Bosutinib SRC, ABL, TEC 4 41 0.693147180559945 NA 1.82847744163144 2.74397620518106 -0.915498763549622 0.99134508078904 0.896207081617949 1.01365068418252 0.923491507942875 1.0215259199881 0.0595724658508494 NA NA NA 0.160378343131777 88.9585084703157 a775 gain_cnaBRCA31 258 STF-62247 stimulates autophagy 16 33 2.32630161961136 NA 5.0000603618553 4.45182838103148 0.548231980823825 0.761793766359708 1.00215864829053 0.588102676079066 0.719659315989937 0.547051089923726 0.0595893980782137 NA NA NA 0.040328497750083 88.9585084703157 a776 gain_cnaBRCA8_(CHD4,WNK1) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 3 42 -0.669430653942629 NA -6.022827713223 -3.30500318858143 -2.71782452464157 1.15666485443148 2.39364839966263 1.15622919933049 2.34970788143938 1.13543180570072 0.0596181039579972 NA NA NA 0.0309006473576496 88.9585084703157 a777 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 5 Sunitinib PDGFRA, PDGFRB, KDR, KIT, FLT3 3 9 2.07944154167984 NA 4.52596480435936 2.83188338687556 1.6940814174838 0.338685709065353 1.33010807579724 1.41257269521552 5.00192766372941 1.27364193053892 0.0601389818969226 NA NA NA 0.00583964849357065 89.157604891963 a778 gain_cnaBRCA16 1023 GW 441756 NTRK1 15 30 0.693147180559945 NA 2.87130110474546 2.10327963396934 0.76802147077612 1.11347741947557 1.32337379691991 0.610081423749417 0.689750377818929 0.580351124197602 0.0603163741705226 NA NA NA 0.048924784950514 89.157604891963 a779 gain_cnaBRCA63 257 NPK76-II-72-1 PLK3 7 42 2.32630161961136 NA 4.51424194500447 3.30641335574579 1.20782858925868 1.52932531869888 1.5381876063075 0.785804913221935 0.789778717772273 0.785228397567274 0.0603164400583809 NA NA NA 0.0885998342901522 89.157604891963 a780 loss_cnaBRCA23 175 PAC-1 CASP3 agonist 3 45 0.940007258491471 NA 1.1256313032745 2.48643183369568 -1.36080053042119 1.69582029089627 1.15651814346555 1.14827694359492 0.802443830709197 1.17663569578208 0.0603336963061205 NA NA NA 0.297732716322168 89.157604891963 a781 gain_cnaBRCA16 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 10 16 2.30258509299405 NA 5.14270917635317 4.40021839266028 0.74249078369289 0.736586657503385 1.03538298459659 0.794450386103056 1.00801552149956 0.717117042426751 0.0603870568893931 NA NA NA 0.043660637647083 89.157604891963 a782 gain_cnaBRCA14_(RAD21) 3 Rapamycin MTOR 6 8 -2.30258509299405 NA -4.24025606985195 -1.61871918301354 -2.62153688683842 3.4273666344284 1.00606130400541 1.1193602531305 0.764883704154872 2.60574268824509 0.060403780235621 NA NA NA 0.122350994460706 89.157604891963 a783 gain_cnaBRCA30_(CRNKL1,FOXA2) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 4 39 0.693147180559945 NA 3.16545189879768 1.52979267527478 1.6356592235229 0.448530735366905 1.67134082340054 1.01367042478325 3.64670488452683 0.978650913459389 0.0604498442865906 NA NA NA 0.000283928360728502 89.157604891963 a784 MLL3_mut 1016 Temsirolimus MTOR 3 41 -1.6094379124341 NA -0.194016594969218 -1.8648622540528 1.67084565908359 1.89614643840773 1.42202669425637 1.1537969308448 0.881179652182699 1.17497489029721 0.0604931492054798 NA NA NA 0.264049772704121 89.157604891963 a785 gain_cnaBRCA10_(MDM2,NUP107) 204 Tipifarnib Farnesyl-transferase (FNTA) 4 44 2.77258872223978 NA 2.97173119396103 1.49708973964135 1.47464145431968 1.33259690605431 1.47659317398392 1.00477546108426 1.10659228429845 0.998678227897418 0.0605548084710091 NA NA NA 0.109289235887831 89.157604891963 a786 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 158 PF-562271 FAK 14 31 0.940007258491471 NA 2.86622858782586 2.09255029097922 0.773678296846639 1.31590535002662 1.21536751549701 0.620621751517959 0.587943727739225 0.636579706945889 0.0605562036236507 NA NA NA 0.0741528340143418 89.157604891963 a787 loss_cnaBRCA7_(FAS,PTEN) 192 LFM-A13 BTK 4 44 2.77258872223978 NA 5.54237863161648 4.72756935086615 0.814809280750331 0.134519758162123 0.838196496591599 1.00453474699951 6.05717176333551 0.972098170373691 0.0606141651578381 NA NA NA 2.40782260564476e-06 89.157604891963 a788 loss_cnaBRCA29_(MAP2K4) 291 KIN001-266 MAP3K8 (COT) 7 42 2.99573227355399 NA 3.00927212163227 3.90686145685002 -0.89758933521775 0.308186274300791 1.21978894584266 0.784207315328015 2.91248965338962 0.735856262902653 0.0608209439169492 NA NA NA 0.000230973233649761 89.157604891963 a789 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 221 TAK-715 p38a 15 34 2.99573227355399 2.32630161961136 4.07881963935393 4.66009377619342 -0.581274136839492 0.894300646067466 1.0093846458611 0.595248413843669 0.649976201398876 0.575869802679245 0.0608903365069212 NA NA NA 0.0529960436508252 89.157604891963 a790 gain_cnaBRCA14_(RAD21) 45 Z-LLNle-CHO g-secretase 6 6 0.940007258491471 NA 0.174183484405173 1.77552781801271 -1.60134433360754 0.852918048265096 1.65034310395856 1.2190481376145 1.87748909389923 0.970309949347205 0.0608931229342822 NA NA NA 0.0700431514455996 89.157604891963 a791 gain_cnaBRCA64_(SDHC) 235 QL-XII-47 BTK, BMX 8 41 2.32630161961136 NA 0.801892376052875 1.88489123506799 -1.08299885901511 1.26222300541903 1.49097870778321 0.742195207589336 0.858009127044536 0.726367756535782 0.0609065251485817 NA NA NA 0.0541016929723821 89.157604891963 a792 loss_cnaBRCA38 272 AR-42 HDAC 4 45 1.63315443905142 NA -1.22331987286952 0.263327597479771 -1.48664747034929 0.68163730065436 1.52372232053033 1.00157132699734 2.18099489115712 0.975668237131202 0.0609849831881579 NA NA NA 0.0104377746984985 89.1597374161213 a793 loss_cnaBRCA36_(FAT1,IRF2) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 9 39 2.77258872223978 NA -1.22282346779603 -0.255074217017469 -0.967749250778558 1.76949853644275 1.2635290645634 0.708941274476425 0.546905934561572 0.765909766478506 0.061449287068494 NA NA NA 0.151830080200078 89.4420818779083 a794 gain_cnaBRCA64_(SDHC) 1164 XMD8-92 MAP2K5 (ERK5) 6 20 2.30258509299405 NA 4.74577421933773 3.62610341696927 1.11967080236846 1.44392685967017 1.16260362611598 0.912865435201295 0.775434569188787 0.963071830516345 0.0615642916055926 NA NA NA 0.125403704450224 89.4420818779083 a795 gain_cnaBRCA30_(CRNKL1,FOXA2) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 4 39 1.6094379124341 NA 4.12971218970402 2.73854836689649 1.39116382280753 1.45041543755041 1.37277830570965 1.00910809726985 0.95914852172082 1.01339292515143 0.0615668767943826 NA NA NA 0.148754131942127 89.4420818779083 a796 loss_cnaBRCA57 1192 GSK269962A ROCK1, ROCK2 5 41 1.6094379124341 NA 3.81553573197828 2.52799338276187 1.28754234921641 1.02562055668305 1.45057453302136 0.908500126987044 1.25537884437538 0.887608543998508 0.061630173838642 NA NA NA 0.0445144125615648 89.4420818779083 a797 ASH1L_mut 1248 FK866 NAMPT 3 41 0 NA -3.45854031801082 -0.445254569318936 -3.01328574869188 3.0883012444045 2.59829896778971 1.14848350205518 0.975709786780505 1.15971479265729 0.0616379713072136 NA NA NA 0.229150737143027 89.4420818779083 a798 gain_cnaBRCA64_(SDHC) 1050 ZM-447439 AURKB 6 33 1.38629436111989 0.693147180559945 3.80505606753815 2.72117281138106 1.08388325615708 1.54749467501846 1.21780754314158 0.855214684115703 0.700411622511175 0.890028364712697 0.0616889464663315 NA NA NA 0.15354488383721 89.4420818779083 a799 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 157 JNK-9L JNK 7 40 1.63315443905142 NA 0.739302161962786 -0.0637608283979204 0.803062990360706 0.993073369492363 1.02755964538797 0.78498582959815 0.808664309235494 0.781524453558602 0.0617330858472058 NA NA NA 0.0834250818588903 89.4420818779083 a800 PTEN_mut 136 Mitomycin C DNA crosslinker 8 40 2.77258872223978 NA -1.01957606814527 0.0427488707688361 -1.06232493891411 1.27558372662207 1.46048242657921 0.740872020298359 0.832814747274406 0.727379473782731 0.0619948582882052 NA NA NA 0.0599082269663305 89.4420818779083 a801 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 221 TAK-715 p38a 6 43 2.99573227355399 2.32630161961136 3.76793770031717 4.58181062276703 -0.813872922449856 0.608086541777479 1.0118265252754 0.833169317912759 1.33841627224778 0.804360136959578 0.0620075898562028 NA NA NA 0.0203299150728984 89.4420818779083 a802 MLL3_mut 222 BX-912 PDPK1 (PDK1) 3 46 2.32630161961136 NA 2.317586063546 3.9859239135431 -1.6683378499971 1.04036227769303 1.48332281877026 1.13708937231646 1.60361240095766 1.12473011868059 0.0624770846337245 NA NA NA 0.0937080585368261 89.4420818779083 a803 loss_cnaBRCA33 266 Zibotentan, ZD4054 Endothelin A Receptor 6 43 2.99573227355399 NA 5.39330088397598 5.79070057062304 -0.397399686647057 0.321350991312135 0.493290254309343 0.831470465849295 1.2366530597102 0.805610253142862 0.0625221535613037 NA NA NA 0.0281846184532798 89.4420818779083 a804 gain_cnaBRCA16 1033 Vismodegib SMO 15 30 2.30258509299405 NA 5.06495295988383 4.6071853745809 0.457767585302931 0.776308618194122 0.747821930944235 0.604541626618721 0.589672167195319 0.612134475282013 0.0625896765159014 NA NA NA 0.0698130844072991 89.4420818779083 a805 gain_cnaBRCA16 1067 CCT007093 PPM1D 16 30 1.88706964903238 NA 4.45377445214936 3.88929583550994 0.564478616639418 0.723473974559001 1.0545580057812 0.591277478177766 0.780233479695659 0.535275075951143 0.0626653937008263 NA NA NA 0.0386234670746447 89.4420818779083 a806 gain_cnaBRCA63 1050 ZM-447439 AURKB 5 34 1.38629436111989 0.693147180559945 3.90401632766367 2.73849875124958 1.16551757641409 1.75949445631403 1.19457358724538 0.91929384477097 0.662416168594095 0.975676667271464 0.0626817418964946 NA NA NA 0.216602843606671 89.4420818779083 a807 gain_cnaBRCA16 1143 HG-5-88-01 EGFR, ADCK4 10 16 2.30258509299405 NA 4.98057941129995 4.25501306987875 0.725566341421199 0.936405928565429 0.913376372207724 0.786880151382568 0.77484167847246 0.794378268913867 0.0626991708212257 NA NA NA 0.0674195642105828 89.4420818779083 a808 gain_cnaBRCA14_(RAD21) 110 Roscovitine CDKs 6 7 2.77258872223978 NA 3.52425596886248 4.55639653603083 -1.03214056716835 0.931148454018393 0.865764918716691 1.15184447829298 1.10845973347657 1.19217185272219 0.0627334618901169 NA NA NA 0.0655725589215205 89.4420818779083 a809 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1069 EHT 1864 Rac GTPases 14 32 2.30258509299405 NA 3.2074107911756 3.71630146216954 -0.508890670993941 0.896141908862935 0.803290323863525 0.61179214290142 0.567868398923162 0.633507781528312 0.0627637071534299 NA NA NA 0.0808467382001226 89.4420818779083 a810 PTEN_mut 326 GSK690693 AKT 9 39 2.32630161961136 NA 1.86720056903349 3.18705002315765 -1.31984945412417 1.53747006745177 1.93488327806414 0.705108510940193 0.858455382036614 0.682133888430046 0.0628130086358732 NA NA NA 0.0441379578718691 89.4420818779083 a811 gain_cnaBRCA47_(EGFR) 156 AZD6482 PI3Kbeta 7 40 1.63315443905142 NA 1.11120243584411 2.21817859101625 -1.10697615517214 1.27064053408888 1.43823348970398 0.781192675358844 0.871195373887469 0.769677637947354 0.062953118165832 NA NA NA 0.0671785828222756 89.4420818779083 a812 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1170 CCT018159 HSP90 8 35 2.30258509299405 NA 4.04411679054275 3.18253392333415 0.861582867208599 1.36127428858762 1.10308317467048 0.748375396701087 0.632923779161752 0.781067907654361 0.0631859806544675 NA NA NA 0.128609785763911 89.4420818779083 a813 loss_cnaBRCA33 1091 BMS-536924 IGF1R 5 42 1.38629436111989 NA 2.16914158375674 3.12498800912754 -0.955846425370801 0.587453538253915 1.0963441296247 0.900858668461599 1.62710131632173 0.871848901765916 0.0632866997761462 NA NA NA 0.0159085153230393 89.4420818779083 a814 loss_cnaBRCA33 133 Doxorubicin DNA intercalating 6 42 0.0237165266173161 NA -2.32435325979403 -0.845829515496788 -1.47852374429724 1.9334312793998 1.76072643848924 0.830486471570283 0.764714919040836 0.839723714017643 0.0633254688781703 NA NA NA 0.124982145723877 89.4420818779083 a815 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 177 GSK-650394 SGK3 7 40 2.77258872223978 NA 5.10580731264171 3.82344932348713 1.28235798915457 1.53398300666766 1.66045592869195 0.779949540111881 0.835966228817814 0.772292698045151 0.0633574174081492 NA NA NA 0.075994351483981 89.4420818779083 a816 POLR2B_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 3 40 2.30258509299405 NA 2.63307113382727 3.89715910756041 -1.26408797373314 1.68777734178936 1.06825918538179 1.14236239295148 0.748966076528182 1.18331580110061 0.0633632139991081 NA NA NA 0.323155957723193 89.4420818779083 a817 loss_cnaBRCA42 271 VNLG/124 HDAC, RAR 3 46 1.63315443905142 NA 3.3118961165649 4.2061929744828 -0.894296857917903 0.95798692725954 0.78111156248789 1.13281592184807 0.933516765699683 1.14490285493856 0.0634326759630711 NA NA NA 0.244256365967769 89.4420818779083 a818 loss_cnaBRCA24 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 3 43 2.30258509299405 NA 2.43754736787073 1.34170706975603 1.0958402981147 0.274616671185855 0.985007190533026 1.13659911427853 3.99043617192874 1.11252010000221 0.0635467256610313 NA NA NA 0.00157747214931314 89.4420818779083 a819 gain_cnaBRCA58_(CCND1) 275 I-BET BRD2, BRD3, BRD4 10 39 2.99573227355399 NA 4.7463078289066 3.85756496456901 0.888742864337591 1.85470788117014 1.15721420705574 0.673478520448586 0.479182125315 0.768002033606888 0.0635753293596966 NA NA NA 0.17671058291437 89.4420818779083 a820 TP53_mut 1069 EHT 1864 Rac GTPases 36 10 2.30258509299405 NA 3.68445423091005 3.11850455531218 0.565949675597871 0.845766050967539 0.776222628746432 0.680216300110843 0.669156293221318 0.729107416659389 0.0636076412962225 NA NA NA 0.0634305113144485 89.4420818779083 a821 gain_cnaBRCA16 1006 Cytarabine DNA synthesis 15 30 0.693147180559945 NA 1.8024286312402 0.911585596570862 0.890843034669341 1.45679627444913 1.49066110097209 0.602034690600141 0.611508314713531 0.597616073893927 0.0636422886132577 NA NA NA 0.0650083134033385 89.4420818779083 a822 gain_cnaBRCA12_(TERT) 293 MP470 PDGFR 9 39 2.99573227355399 NA 4.45645626141308 3.31815338640793 1.13830287500516 0.666001526039706 1.75589326717507 0.702696293385135 1.70915955969941 0.648275664748401 0.0636844755481382 NA NA NA 0.00308980682183048 89.4420818779083 a823 loss_cnaBRCA18 265 Tubastatin A HDAC6 16 33 2.99573227355399 NA 4.30036635091491 4.88152586539048 -0.581159514475572 0.81188417223939 1.08361826319438 0.57832009232808 0.715815795340093 0.536313879356721 0.0637935351088627 NA NA NA 0.0425627344774962 89.4420818779083 a824 loss_cnaBRCA57 221 TAK-715 p38a 5 44 2.99573227355399 2.32630161961136 5.26824910250385 4.3928235788265 0.875425523677352 0.711937609001074 0.998458875821762 0.89571369202732 1.22963798036414 0.876776745518788 0.0638552216665602 NA NA NA 0.0476979897538049 89.4420818779083 a825 loss_cnaBRCA18 256 JW-7-24-1 LCK 15 33 2.32630161961136 NA 1.37860913112077 2.04618730933009 -0.667578178209324 0.526380900780365 1.30838348743218 0.591172666049967 1.2682416425437 0.510231277467056 0.0639224523878611 NA NA NA 0.0154157345787485 89.4420818779083 a826 loss_cnaBRCA24 230 GSK429286A ROCK2 3 46 2.99573227355399 2.32630161961136 4.48129851303935 5.46577782990523 -0.984479316865883 0.868252096203445 0.871084206408 1.13033311824105 1.13386344953345 1.13017697901501 0.063993562155893 NA NA NA 0.182065678609091 89.4420818779083 a827 loss_cnaBRCA33 231 FMK RSK 6 43 2.99573227355399 2.32630161961136 5.17149540061399 5.64751820389125 -0.476022803277251 0.593204303856644 0.574133405806791 0.826152765502619 0.802460130822465 0.829115321391774 0.0641564470094636 NA NA NA 0.111103429081566 89.4420818779083 a828 gain_cnaBRCA8_(CHD4,WNK1) 1529 MLN4924 NEDD8-activating enzyme 3 34 0 NA -1.35852340876581 0.521662803036395 -1.8801862118022 1.54011763953489 1.63864476110209 1.15124617659506 1.22080688094061 1.14740318123475 0.0641601464691623 NA NA NA 0.158818858861448 89.4420818779083 a829 loss_cnaBRCA33 330 XMD13-2 RIPK 6 42 2.32630161961136 NA 2.86610433950333 3.84315223072919 -0.977047891225862 0.671069211972442 1.22826512163644 0.82764939153202 1.4559569621054 0.795469865597199 0.0641999529824617 NA NA NA 0.0140767150984021 89.4420818779083 a830 gain_cnaBRCA30_(CRNKL1,FOXA2) 1030 KU-55933 ATM 4 38 2.30258509299405 NA 5.02860191280453 4.13742540159982 0.891176511204707 0.708721496913138 0.904043525016727 1.00033164441858 1.25744247223523 0.985767262907191 0.0642538713523147 NA NA NA 0.0791111942793439 89.4420818779083 a831 loss_cnaBRCA57 1039 SL 0101-1 RSK, AURKB, PIM3 5 38 2.30258509299405 NA 5.39401885932937 4.55077697755404 0.843241881775335 0.306054983375633 0.97618333598748 0.904516477150383 2.75519735857525 0.863815075190087 0.0643017249868509 NA NA NA 0.000763690245687661 89.4420818779083 a832 TP53_mut 5 Sunitinib PDGFRA, PDGFRB, KDR, KIT, FLT3 9 3 2.07944154167984 NA 3.67320158215144 2.00201021853172 1.67119136361972 1.28746195915982 0.80491302773955 1.38516539605366 1.29805106219241 2.07623843325403 0.0644408443043642 NA NA NA 0.0396383004875456 89.4420818779083 a833 loss_cnaBRCA22_(SYNCRIP,ZNF292) 272 AR-42 HDAC 19 30 1.63315443905142 NA 0.646919280874014 -0.177833464716489 0.824752745590503 1.87423719522077 1.18214162215483 0.555093226638481 0.440047155020502 0.6976767674309 0.0644920334398803 NA NA NA 0.0978759708322735 89.4420818779083 a834 loss_cnaBRCA57 170 Shikonin unknown 5 42 2.77258872223978 NA 0.925550642875547 -0.106147068575603 1.03169771145115 0.779475564080596 1.18082001788022 0.896483937674421 1.32357928714296 0.873712924771742 0.0645313751740049 NA NA NA 0.0369517090969159 89.4420818779083 a835 gain_cnaBRCA27_(CLTC,PPM1D) 1069 EHT 1864 Rac GTPases 10 36 2.30258509299405 NA 3.12004863256247 3.68402532056275 -0.56397668800028 0.999973596153692 0.783341264387177 0.677650909195304 0.563991579547266 0.719962950555771 0.0645745870970415 NA NA NA 0.124661275562733 89.4420818779083 a836 gain_cnaBRCA47_(EGFR) 301 PHA-793887 CDK-pan 7 41 2.32630161961136 NA 1.86837149926665 3.10220378049196 -1.23383228122531 1.70458106922351 1.57588622247564 0.774406327225224 0.723833147922592 0.782945027139723 0.0645768895845335 NA NA NA 0.112107369297302 89.4420818779083 a837 gain_cnaBRCA16 1028 VX-702 p38 15 30 0.693147180559945 NA 3.69138054185185 3.29455687678134 0.396823665070508 0.742134840473361 0.61998618831881 0.599219954203127 0.534705613359157 0.640052427855785 0.0648421421528462 NA NA NA 0.0872014502916258 89.7021701299649 a838 gain_cnaBRCA31 346 THZ-2-102-1 CDK7 16 32 0.916290731874155 2.99573227355399 -0.38273132890162 -1.81137079356739 1.42863946466577 2.60149346100696 2.40357596753312 0.578429910652162 0.549161274506061 0.594380824223348 0.065185845983039 NA NA NA 0.0765228125522598 90.070037068927 a839 gain_cnaBRCA62 194 AUY922 HSP90 9 38 -1.36257783450257 NA -1.44500084611031 -2.6184501289793 1.17344928286899 2.21972790168074 1.53301764720621 0.70023485444151 0.52864555244833 0.765450603264413 0.0653608993490733 NA NA NA 0.164028454904114 90.1159540379495 a840 ASH1L_mut 1054 PD-0332991 CDK4, CDK6 3 39 1.38629436111989 0.693147180559945 1.390479589932 2.99770667280678 -1.60722708287477 1.21033832116043 1.42618736596252 1.13490592766074 1.3279155544987 1.12693964428024 0.0654437921886159 NA NA NA 0.13665288345772 90.1159540379495 a841 gain_cnaBRCA19 306 TG101348 JAK2 4 44 2.32630161961136 NA 2.09968685172611 3.32718002983267 -1.22749317810655 0.434521697213088 1.28316045894756 0.985490509950741 2.82492953972007 0.956617054045868 0.0654706149802257 NA NA NA 0.00211437398390635 90.1159540379495 a842 gain_cnaBRCA48 306 TG101348 JAK2 5 43 2.32630161961136 NA 4.21958554956232 3.10922653422629 1.11035901533604 1.19725400711402 1.25009191314149 0.891434837687754 0.92742142330562 0.888221900856628 0.0655303854391169 NA NA NA 0.107363772345981 90.1159540379495 a843 gain_cnaBRCA31 106 XMD8-85 MAP2K5 (ERK5) 4 9 2.07944154167984 NA 4.13541909480028 2.819004863865 1.31641423093528 1.1127420220738 1.05705153804749 1.22739533361094 1.18303632362324 1.24536428315205 0.0658192128795246 NA NA NA 0.0963877729918872 90.405772945672 a844 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 291 KIN001-266 MAP3K8 (COT) 6 43 2.99573227355399 NA 2.95352725762527 3.89376563938082 -0.940238381755555 0.340954989297168 1.20683691578306 0.820276120980529 2.75766130800352 0.779093156216124 0.066004725128721 NA NA NA 0.000349621777605732 90.4647509157373 a845 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 265 Tubastatin A HDAC6 6 43 2.99573227355399 NA 3.9679890222841 4.79275072183302 -0.824761699548924 0.665180040776558 1.03863566747267 0.820233141220817 1.23990746713636 0.794081818464635 0.0660184079141532 NA NA NA 0.0280092547385572 90.4647509157373 a846 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 106 XMD8-85 MAP2K5 (ERK5) 4 9 2.07944154167984 NA 4.13355729482434 2.81983233052098 1.31372496430336 1.11637800704231 1.05677195176594 1.22394097491892 1.17677431480748 1.2431489708901 0.0664735074473675 NA NA NA 0.0976689010814544 90.8258219695696 a847 gain_cnaBRCA64_(SDHC) 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 6 20 2.30258509299405 NA 3.49212693716568 2.45136730477562 1.04075963239007 1.32826932502713 1.11586704192092 0.894646031183985 0.783545635497383 0.932691434813278 0.0665544837727194 NA NA NA 0.123249473768041 90.8258219695696 a848 loss_cnaBRCA57 266 Zibotentan, ZD4054 Endothelin A Receptor 5 44 2.99573227355399 NA 6.12284106568115 5.69876646618729 0.424074599493854 0.245535742290134 0.494607019665459 0.886288041655369 1.72713999004166 0.857397049845125 0.0665977437575665 NA NA NA 0.0119750364666353 90.8258219695696 a849 gain_cnaBRCA64_(SDHC) 1268 XAV 939 TNKS1 (tankyrase-1) 9 38 1.6094379124341 NA 4.17480918906753 3.5398558823545 0.634953306713038 1.15587384740782 0.849417729967569 0.696632534374673 0.549327513670277 0.747515956297828 0.0667058212688671 NA NA NA 0.151349387088701 90.8258219695696 a850 gain_cnaBRCA61_(NOTCH2) 164 JQ12 HDAC 3 44 1.63315443905142 NA 3.24961748632297 1.4639012861929 1.78571620013007 2.0376226810663 1.56912354292213 1.12106525134962 0.876372361145685 1.13803416447668 0.0667656102740897 NA NA NA 0.265985434623162 90.8258219695696 a851 loss_cnaBRCA33 1036 PLX4720 BRAF 5 38 2.30258509299405 NA 3.67562036951745 4.71779927264245 -1.042178903125 2.52243283077273 0.900884098873684 0.895916687003691 0.413164184358374 1.15684015782715 0.0667722783245989 NA NA NA 0.409812949427072 90.8258219695696 a852 gain_cnaBRCA14_(RAD21) 1021 Axitinib PDGFR, KIT, VEGFR 20 25 0.693147180559945 NA 2.81767377365782 2.17809433019491 0.639579443462906 1.12073632507978 1.14476355567625 0.563898790706567 0.570677891980862 0.558700039227824 0.0669409690187449 NA NA NA 0.0666036506176091 90.8258219695696 a853 loss_cnaBRCA18 1001 AICAR AAPK1 (AMPK) agonist 14 31 7.60090245954208 NA 7.18067742397817 7.9903956248643 -0.809718200886126 1.22398578132252 1.38462855026882 0.605126416394099 0.661542162696712 0.584790917917245 0.0669985053889131 NA NA NA 0.0586432023364521 90.8258219695696 a854 MACF1_mut 1199 Tamoxifen ER 3 44 1.6094379124341 NA 2.9000846010977 3.93524424192031 -1.03515964082261 0.323196569589434 0.943727616801257 1.11905480976258 3.20287941836016 1.09688391268156 0.0672377522702779 NA NA NA 0.00720008340069643 90.8258219695696 a855 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 156 AZD6482 PI3Kbeta 5 42 1.63315443905142 NA 0.928496975687618 2.18721609078859 -1.25871911510097 1.15159008192357 1.44218455824807 0.887192778388481 1.09302705438245 0.872786432154033 0.0672442336330164 NA NA NA 0.0690545724386794 90.8258219695696 a856 loss_cnaBRCA33 91 KIN001-135 IKKE 5 9 1.6094379124341 NA 3.44357955690834 3.84780436203126 -0.404224805122917 0.385708692745326 0.347300118616417 1.12110935532328 1.04800543188643 1.16390632612876 0.0674634762143838 NA NA NA 0.0892662207281897 90.8258219695696 a857 NF1_mut 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 5 44 1.63315443905142 NA 4.34728944912427 3.48908501740598 0.858204431718294 0.305257044334461 1.01176819102912 0.883066592854102 2.81141565001194 0.848222388613907 0.0675577454512183 NA NA NA 0.000567701990326275 90.8258219695696 a858 gain_cnaBRCA14_(RAD21) 1199 Tamoxifen ER 21 26 1.6094379124341 NA 4.15036960684199 3.64204764246558 0.508321964376404 0.843810428886793 0.985354108051561 0.549464028521398 0.60241251704724 0.515877449764288 0.0676041725439292 NA NA NA 0.0632931363587199 90.8258219695696 a859 loss_cnaBRCA57 277 ABT-869 VEGFR and PDGFR family 5 43 0.0237165266173161 NA 3.05692865405512 2.64853750302582 0.408391151029293 0.356714846557244 0.470566306152832 0.884381157956431 1.14486726574683 0.867871638256766 0.0676136371570406 NA NA NA 0.0600373329805499 90.8258219695696 a860 gain_cnaBRCA27_(CLTC,PPM1D) 196 Phenformin AAPK1 (AMPK) agonist 9 39 8.29404964010203 NA 6.2129039602884 7.43026903568784 -1.21736507539944 2.4863265688959 1.56416033044424 0.691840905060862 0.489623965986106 0.778286631942448 0.0677349327456881 NA NA NA 0.191522730028598 90.8258219695696 a861 gain_cnaBRCA64_(SDHC) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 9 36 2.30258509299405 NA 2.47169336029424 3.35316038269965 -0.881467022405417 1.86167014598449 1.07961076559105 0.698277611507184 0.4734818487081 0.816467425575221 0.0677813664802884 NA NA NA 0.204300579245867 90.8258219695696 a862 loss_cnaBRCA33 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 40 2.30258509299405 NA 2.17961040232701 3.30152405020501 -1.12191364787801 2.63292834200166 1.02271590677973 0.888753126303163 0.426108690457212 1.09699442478666 0.0677840961168004 NA NA NA 0.396815047531169 90.8258219695696 a863 MLL3_mut 223 ZSTK474 PI3K 3 46 1.63315443905142 2.32630161961136 -0.559176690220619 1.00830630817295 -1.56748299839357 0.0256564963258851 1.43796479144854 1.11402307420356 61.0949748743409 1.09007049944148 0.0677841834264027 NA NA NA 2.69180428030059e-09 90.8258219695696 a864 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 346 THZ-2-102-1 CDK7 15 33 0.916290731874155 2.99573227355399 -0.345716563163934 -1.78490358209465 1.43918701893071 2.51608627428529 2.45197803809643 0.582274240918513 0.571994304662514 0.586949392111199 0.0678751092249694 NA NA NA 0.0752639454208424 90.8258219695696 a865 PTEN_mut 1021 Axitinib PDGFR, KIT, VEGFR 7 38 0.693147180559945 NA 1.7245243685565 2.59826745126668 -0.87374308271018 0.72631384484692 1.1875911800775 0.770128416555472 1.20298282747775 0.735727157095562 0.0679621145666458 NA NA NA 0.0219452078516488 90.8258219695696 a866 gain_cnaBRCA64_(SDHC) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 8 35 1.6094379124341 NA 2.07482453786462 3.14501106818068 -1.07018653031605 2.39088216981103 1.1760528692818 0.734501824326382 0.447611573597807 0.909981649863756 0.0680273882546087 NA NA NA 0.253687777632592 90.8258219695696 a867 gain_cnaBRCA16 1005 Cisplatin DNA crosslinker 15 30 1.79175946922805 2.30258509299405 4.12246855069145 3.4438910520335 0.678577498657955 1.18564455590987 1.12704069440182 0.591894561957985 0.572327933591538 0.602087841218647 0.0680556667935327 NA NA NA 0.0768950243898979 90.8258219695696 a868 loss_cnaBRCA18 255 CP724714 ERBB2 15 33 2.32630161961136 NA 4.45110268780601 3.50845977495303 0.942642912852977 0.626642133455791 1.89869387539263 0.581550006055492 1.50427630465017 0.496469138637764 0.0682057607337841 NA NA NA 0.0139692046865118 90.8258219695696 a869 gain_cnaBRCA19 229 LY317615 PRKCB (PKCbeta) 4 45 2.99573227355399 2.32630161961136 1.95553023858964 3.4832988794204 -1.52776864083076 2.08254085428204 1.52745443475199 0.973867242830365 0.73360800470705 1.00020570569676 0.0682111743577392 NA NA NA 0.239446390749095 90.8258219695696 a870 gain_cnaBRCA27_(CLTC,PPM1D) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 10 33 0.693147180559945 NA 2.52077436465497 1.4277569177078 1.09301744694717 1.06059337152424 1.74253555307948 0.675679018140622 1.03057163687185 0.627256898727575 0.0683777647423698 NA NA NA 0.0232624415886859 90.8258219695696 a871 gain_cnaBRCA10_(MDM2,NUP107) 156 AZD6482 PI3Kbeta 4 43 1.63315443905142 NA 3.32065310204901 1.93541740193867 1.38523570011034 0.296655242204109 1.46688213620084 0.976060249663011 4.66951364087898 0.944340152439272 0.0683952847410875 NA NA NA 2.94541363394675e-05 90.8258219695696 a872 loss_cnaBRCA33 136 Mitomycin C DNA crosslinker 6 42 2.77258872223978 NA -1.15799668446057 0.0119363426751113 -1.16993302713568 1.41733613537343 1.43875450620999 0.814465961456968 0.825445000615494 0.813156811732637 0.0683997899278562 NA NA NA 0.103801460155409 90.8258219695696 a873 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1050 ZM-447439 AURKB 13 26 1.38629436111989 0.693147180559945 3.42750149968282 2.6181353724972 0.809366127185618 1.20004995678356 1.30287538868158 0.637076044784127 0.674443695123266 0.621215301337945 0.0686317496369824 NA NA NA 0.0647370069921875 90.9144113610493 a874 loss_cnaBRCA23 1527 GDC0941 (rescreen) PI3K 3 42 1.38629436111989 NA 2.14812118262229 0.897265459845138 1.25085572277715 0.890640593365696 1.1309784984547 1.11589571305523 1.40444499396801 1.1059942558468 0.0686931611596993 NA NA NA 0.122732654961077 90.9144113610493 a875 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 7 40 2.32630161961136 NA 0.449603565569989 1.58621950041635 -1.13661593484636 1.56681420208311 1.4757159128997 0.763760050922391 0.725431217903954 0.770213240170988 0.0688282874278278 NA NA NA 0.112075700720209 90.9144113610493 a876 gain_cnaBRCA63 179 5-Fluorouracil DNA antimetabolite 7 42 3.46573590279973 NA 3.01641153382457 4.21232088042552 -1.19590934660094 1.42041398486643 1.59441441519131 0.760140784068591 0.841944221433024 0.750061800248747 0.0688680402112884 NA NA NA 0.0744956502527054 90.9144113610493 a877 gain_cnaBRCA9_(KRAS) 1091 BMS-536924 IGF1R 4 43 1.38629436111989 NA 3.97043211702235 2.93519711241979 1.03523500460256 0.264054092885303 1.09774926959247 0.97414097654605 3.92054140608316 0.943052328321642 0.068920588032476 NA NA NA 0.00014323462181229 90.9144113610493 a878 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 167 OSU-03012 PDPK1 (PDK1) 6 42 2.77258872223978 NA 1.42974578492262 2.36486949082169 -0.935123705899068 0.852939134193168 1.18162630673618 0.812827800802709 1.09635455615909 0.791387006677273 0.0689376052983861 NA NA NA 0.0444443737698281 90.9144113610493 a879 gain_cnaBRCA64_(SDHC) 223 ZSTK474 PI3K 8 41 1.63315443905142 2.32630161961136 0.0652923916397086 1.07761514566284 -1.01232275402313 0.92953794289442 1.47530767070069 0.719234829187263 1.08906017420971 0.686177381252503 0.0690285100550825 NA NA NA 0.0235053245741897 90.9307301396815 a880 gain_cnaBRCA12_(TERT) 291 KIN001-266 MAP3K8 (COT) 9 40 2.99573227355399 NA 3.13594299299677 3.9232399775539 -0.787296984557131 0.741887728685436 1.21370464867799 0.686287711628552 1.06120771932993 0.648672628398252 0.0691212631771198 NA NA NA 0.020996250399197 90.9494439008943 a881 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 202 GSK-1904529A IGF1R 7 41 0.0237165266173161 NA 2.71540699467193 2.09991520567374 0.615491788998187 0.959203616239386 0.784351963046229 0.760519976020838 0.641669587747446 0.784713773913141 0.0693373146342654 NA NA NA 0.149289197171732 91.1301664188603 a882 gain_cnaBRCA19 305 TPCA-1 IKK 4 45 2.99573227355399 NA 2.98318565812556 4.28456109521704 -1.30137543709149 1.17632081108646 1.3534316085093 0.969132719204548 1.1063099664874 0.961537641731931 0.0695161532426396 NA NA NA 0.109225944743544 91.1597015437334 a883 gain_cnaBRCA14_(RAD21) 111 Salubrinal GADD34-PP1C 6 7 2.77258872223978 NA 2.64552896076465 3.74384209050563 -1.09831312974097 0.54803733532256 1.23166360108501 1.11864911806288 2.00408450109432 0.891731418200092 0.0695172436852203 NA NA NA 0.0639865168460712 91.1597015437334 a884 gain_cnaBRCA16 1007 Docetaxel Microtubules 15 30 -4.38202663467388 NA -4.00040306239529 -4.88071795209308 0.880314889697791 1.67566845848636 1.40246859046777 0.588091311830954 0.52535147107381 0.627689558027232 0.0697768981005054 NA NA NA 0.0926662061527619 91.3966858716914 a885 loss_cnaBRCA22_(SYNCRIP,ZNF292) 277 ABT-869 VEGFR and PDGFR family 18 30 0.0237165266173161 NA 2.85080752570457 2.59524068125679 0.255566844447779 0.58590230024317 0.370723001838081 0.553090711396227 0.43619361852942 0.689374123484795 0.0699938296702412 NA NA NA 0.108908396659353 91.5772377120591 a886 gain_cnaBRCA63 203 BMS-345541 IKBKB 7 42 2.77258872223978 NA 2.89672518874167 3.63826663822003 -0.741541449478365 1.40604625079466 0.901557233393309 0.756272785929332 0.527394777418785 0.822511785177885 0.0702421710705627 NA NA NA 0.219984757691894 91.7813442500737 a887 loss_cnaBRCA17 1001 AICAR AAPK1 (AMPK) agonist 8 37 7.60090245954208 NA 6.94192541313257 7.91071202706559 -0.968786613933025 1.48630807320483 1.30891920407206 0.723299832908609 0.651807408839605 0.740142409798189 0.0704519370930893 NA NA NA 0.120428176363509 91.7813442500737 a888 gain_cnaBRCA14_(RAD21) 11 Paclitaxel Microtubules 6 6 -2.27886856637673 NA -4.00412487716901 -2.18428359229194 -1.81984128487708 1.4194513460617 1.68349626540361 1.16875192285495 1.28207373216861 1.08098920221886 0.0704680296210397 NA NA NA 0.071273171086003 91.7813442500737 a889 loss_cnaBRCA18 290 KIN001-260 IKK 16 33 2.99573227355399 NA 4.65936265672198 5.23060016993987 -0.571237513217891 1.34251110132414 0.814561149145057 0.563688132414699 0.425499284627495 0.701282541915297 0.0705521677402389 NA NA NA 0.132211497163244 91.7813442500737 a890 gain_cnaBRCA62 1219 PFI-1 BRD2, BRD3, BRD4 8 39 2.30258509299405 NA 3.750632268463 3.05388594325215 0.696746325210849 1.3827957819176 0.872135103867273 0.71873738825365 0.503867841023229 0.79889723750517 0.0706194699274173 NA NA NA 0.207010408805394 91.7813442500737 a891 gain_cnaBRCA31 1005 Cisplatin DNA crosslinker 14 31 1.79175946922805 2.30258509299405 4.14188178304518 3.45701338254014 0.684868400505039 1.38834807482731 1.02535045675778 0.596954235149964 0.493297331499687 0.667935919851865 0.07062542337578 NA NA NA 0.114133311516287 91.7813442500737 a892 loss_cnaBRCA33 1218 JQ1 BRD2, BRD3, BRD4 5 41 0 NA 1.92522776219017 2.52295188539965 -0.597724123209484 0.858739579886522 0.661263900858441 0.876962492009946 0.696048181788092 0.903911618997391 0.0708439426110269 NA NA NA 0.198146691596609 91.7944673750821 a893 gain_cnaBRCA58_(CCND1) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 9 39 2.77258872223978 NA 0.323885296835583 -0.612007008855533 0.935892305691116 0.772446800473256 1.4634699691126 0.683837258718887 1.21159451384577 0.639502227885555 0.0708597008039031 NA NA NA 0.0130231882484051 91.7944673750821 a894 loss_cnaBRCA23 1241 CHIR-99021 GSK3B 3 43 2.30258509299405 NA 5.21216380711125 4.16306778681548 1.04909602029577 0.217291328116608 0.97033356893142 1.10529437543641 4.82806207403169 1.08117049011413 0.0708972029411807 NA NA NA 0.000254126953832685 91.7944673750821 a895 gain_cnaBRCA27_(CLTC,PPM1D) 164 JQ12 HDAC 9 38 1.63315443905142 NA 0.693873615116998 1.78725385566852 -1.09338024055152 1.59349409121643 1.59491693203114 0.685649258336395 0.686152679560213 0.685540556121055 0.0709526282932019 NA NA NA 0.0887859425788215 91.7944673750821 a896 MLL3_mut 1377 Afatinib (rescreen) ERBB2, EGFR 3 44 2.30258509299405 NA 0.841547437985351 2.97053281354934 -2.12898537556399 1.3099649226705 1.95574821461749 1.10216656835527 1.62522319393394 1.08857845792812 0.0713171154075701 NA NA NA 0.0896062085882169 92.1470116180913 a897 gain_cnaBRCA64_(SDHC) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 7 36 -1.38629436111989 0.693147180559945 -1.63031503942026 -2.33527150506361 0.704956465643354 1.44904726665653 0.798532203910558 0.76390627341817 0.486496529040036 0.882815323152973 0.071633652001876 NA NA NA 0.252780438288366 92.1470116180913 a898 loss_cnaBRCA36_(FAT1,IRF2) 283 GSK2126458 PI3K, MTOR 9 39 -2.05572501506252 0.0237165266173161 -2.17525957989664 -3.25845751726334 1.0831979373667 1.4699289920129 1.61270260519774 0.681773551076842 0.736904941158678 0.671666266226366 0.0716849321708399 NA NA NA 0.0725916755187138 92.1470116180913 a899 gain_cnaBRCA62 283 GSK2126458 PI3K, MTOR 10 38 -2.05572501506252 0.0237165266173161 -3.87934102506252 -2.83852024057144 -1.04082078449108 0.936879992446489 1.71022599894793 0.655090594857634 1.11094354974234 0.608586692712752 0.071748374710897 NA NA NA 0.0162873882014174 92.1470116180913 a900 gain_cnaBRCA12_(TERT) 1009 ATRA Retinoic acid and retinoid X receptor agonist 10 35 2.30258509299405 NA 4.68420725388366 3.94076047664357 0.743446777240087 0.915223228539493 1.17196672289685 0.661961381867723 0.812311962871042 0.634358265226548 0.0717655982162533 NA NA NA 0.0479130268752771 92.1470116180913 a901 gain_cnaBRCA13_(FGFR1,WHSC1L1) 91 KIN001-135 IKKE 4 10 1.6094379124341 NA 4.0055997227941 3.58257381516466 0.423025907629446 0.23873432645934 0.394822049625414 1.16805471327182 1.77195258806443 1.07143435385838 0.0718067970716381 NA NA NA 0.0357390821667425 92.1470116180913 a902 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 261 TL-1-85 MAP3K7 (TAK1) 6 43 2.32630161961136 NA 3.19461512602427 4.14064711802435 -0.946031992000073 0.767684158146123 1.21893097371019 0.802291133631663 1.23231928386362 0.776116131597291 0.0719448682467299 NA NA NA 0.0289058917008677 92.1470116180913 a903 gain_cnaBRCA31 140 Vinorelbine Microtubules 16 31 -2.74887219562247 NA -3.00161318726876 -3.90856753041787 0.90695434314911 1.69752574436147 1.54867627453599 0.566905887166441 0.534280169924765 0.58563197361621 0.0721256803825009 NA NA NA 0.0846758964021694 92.1470116180913 a904 gain_cnaBRCA48 178 BAY 61-3606 SYK 5 43 2.07944154167984 NA 1.87862504704061 3.23727930708125 -1.35865426004064 1.47764471074302 1.57003196703618 0.869697247149569 0.919472895048944 0.865367259117299 0.0721313451399477 NA NA NA 0.109807559327904 92.1470116180913 a905 POLR2B_mut 255 CP724714 ERBB2 3 45 2.32630161961136 NA 2.13371602131704 3.91432366281309 -1.78060764149605 3.43737042177314 1.48839412050641 1.09740300489623 0.518014477059921 1.19632805381563 0.0721657256621908 NA NA NA 0.464662866482371 92.1470116180913 a906 gain_cnaBRCA12_(TERT) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 10 35 2.30258509299405 NA 1.91505307759236 1.20825856897035 0.706794508622009 0.918111419520765 1.10648081537982 0.660677411971172 0.769835222168287 0.638777011582788 0.0722976915424568 NA NA NA 0.0562684748122168 92.1470116180913 a907 gain_cnaBRCA31 37 Crizotinib MET, ALK 4 10 0.693147180559945 NA 3.23482750339499 2.41927847380934 0.815549029585649 0.428124365830485 0.769193197803015 1.16558604746729 1.90493486163449 1.06026552485778 0.0723324749612533 NA NA NA 0.0302870028026094 92.1470116180913 a908 gain_cnaBRCA27_(CLTC,PPM1D) 228 KIN001-102 AKT1 9 40 2.32630161961136 NA 1.18583533985976 2.11422395360719 -0.928388613747434 1.79458013268871 1.26389903447372 0.678232676459478 0.517329149496649 0.734543336473085 0.0723325772491405 NA NA NA 0.172200882885354 92.1470116180913 a909 gain_cnaBRCA16 341 EX-527 SIRT1 16 33 2.99573227355399 NA 5.88191235316506 5.52531245606595 0.356599897099111 0.604459880253876 0.651592190143095 0.559873851070885 0.589947999442638 0.547274664266308 0.072410542659619 NA NA NA 0.0682454880784185 92.1470116180913 a910 loss_cnaBRCA29_(MAP2K4) 1061 SB590885 BRAF 4 38 1.6094379124341 NA 3.08740585121572 4.1092281011726 -1.02182224995688 2.38977319646193 0.85834017508198 0.969950297210851 0.427581266485747 1.19046303507731 0.0724188449541956 NA NA NA 0.456543785824244 92.1470116180913 a911 loss_cnaBRCA33 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 5 38 1.6094379124341 NA 1.79693191819017 3.0088835651797 -1.21195164698952 1.31817738974392 1.39015433442016 0.876132591087716 0.919414683045785 0.871810860838723 0.0727650034022084 NA NA NA 0.110210911714005 92.3957820572735 a912 NF1_mut 1031 Elesclomol HSP70 4 40 -1.6094379124341 NA -1.45860796484924 -3.12947618114289 1.67086821629365 2.0823838714273 1.70168920293798 0.964894231069539 0.802382422962396 0.981888004818319 0.0728451044303489 NA NA NA 0.207153204666423 92.3957820572735 a913 gain_cnaBRCA31 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 16 31 2.77258872223978 NA 5.38229238062367 4.81921585829372 0.563076522329951 0.996807020738916 0.995699778410643 0.565298713866468 0.56488017300736 0.565508333474519 0.0729081061964038 NA NA NA 0.076195635489919 92.3957820572735 a914 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 9 36 -0.669430653942629 NA -2.19285139422998 -3.80952651422275 1.61667511999277 2.65508026226974 2.28695678205551 0.685090752762032 0.608898775290029 0.706911093676072 0.0729335389933051 NA NA NA 0.121167382221422 92.3957820572735 a915 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1019 Bosutinib SRC, ABL, TEC 5 40 0.693147180559945 NA 3.36491272063708 2.57480926439409 0.790103456242988 0.852747611913075 0.912127824821184 0.871340118726567 0.926538456637188 0.866220100672713 0.0731357757846138 NA NA NA 0.107995958723997 92.511984337673 a916 MLL3_mut 304 SB52334 ALK5 3 46 2.99573227355399 NA 3.03133607931593 4.38475407402754 -1.35341799471161 1.85901233232803 1.20439045527448 1.09207309753805 0.728030670467225 1.1237368984323 0.0731850571321431 NA NA NA 0.333830729453105 92.511984337673 a917 gain_cnaBRCA14_(RAD21) 1175 AG-014699 PARP1, PARP2 20 23 1.6094379124341 NA 4.16044663154312 3.60167848943112 0.558768142112 0.903616258118389 1.06775523039021 0.561540562368239 0.618368845283427 0.523311079363945 0.0735191227469403 NA NA NA 0.0702943318096596 92.6452135733775 a918 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1007 Docetaxel Microtubules 15 30 -4.38202663467388 NA -4.00782351624758 -4.87700772516694 0.869184208919365 1.61506071803291 1.43872032061737 0.580069615586645 0.538174323240308 0.604137021256773 0.0735287920967129 NA NA NA 0.0898304269430733 92.6452135733775 a919 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 333 T0901317 LXR 5 43 2.32630161961136 NA 4.15911507007351 4.80245029160601 -0.643335221532492 0.958626144401712 0.719843039013016 0.865097036022252 0.671101268507552 0.893715972324433 0.0735981773050205 NA NA NA 0.211460386084667 92.6452135733775 a920 loss_cnaBRCA17 276 CAY10603 HDAC6 11 38 2.99573227355399 NA 0.706601617315671 1.3112849929942 -0.604683375678527 0.827190009406087 0.999445285187863 0.626372934605204 0.731009041214948 0.605018988673168 0.0736780994520376 NA NA NA 0.0560650418776866 92.6452135733775 a921 POLR2B_mut 1192 GSK269962A ROCK1, ROCK2 3 43 1.6094379124341 NA 1.21367057969528 2.76940454916378 -1.55573396946849 0.125562955503446 1.45523028889714 1.09402773709212 12.3900712852032 1.06906376354186 0.0737135777827394 NA NA NA 4.6505006496579e-08 92.6452135733775 a922 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 184 BMS-754807 IGF1R 15 33 0.940007258491471 NA 2.26639792430606 1.33617396848616 0.930223955819897 1.79605854648712 1.55626317116282 0.569649399385249 0.517925185478672 0.597729209979857 0.0738378569278114 NA NA NA 0.0961233614957567 92.6452135733775 a923 gain_cnaBRCA63 1003 Camptothecin TOP1 6 39 -2.30258509299405 NA -1.45591759726205 -2.69441434353207 1.23849674627002 2.20468781310138 1.43258195829966 0.802993198356342 0.561756063108001 0.864520692233205 0.0740193242141686 NA NA NA 0.233488917674858 92.6452135733775 a924 gain_cnaBRCA62 38 AZD-0530 SRC, ABL1 5 9 0.693147180559945 NA 2.17501530652796 2.81507369410777 -0.640058387579817 0.624973507482099 0.566269725252011 1.09133560234117 1.02413683126904 1.13030656423486 0.0740713714897877 NA NA NA 0.0958084065412268 92.6452135733775 a925 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 230 GSK429286A ROCK2 7 42 2.99573227355399 2.32630161961136 5.96358898854329 5.31248935226085 0.651099636282439 0.838838689218459 0.878153071603182 0.745619787105869 0.776191709623056 0.741442075803222 0.0741472461285489 NA NA NA 0.0941162421485586 92.6452135733775 a926 gain_cnaBRCA31 1021 Axitinib PDGFR, KIT, VEGFR 14 31 0.693147180559945 NA 2.92351429752627 2.25408495363424 0.669429343892034 1.07694105622203 1.16135324282799 0.589029894727721 0.621602584490954 0.576421814832081 0.0743001885356638 NA NA NA 0.0704715693480839 92.6452135733775 a927 PTEN_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 7 36 2.30258509299405 NA 3.10586794373683 3.94568061382612 -0.839812670089281 1.21960032831774 1.09027613674874 0.756490496083226 0.688596625131841 0.770275200733683 0.0743224865796502 NA NA NA 0.12864815112386 92.6452135733775 a928 loss_cnaBRCA23 152 CP466722 ATM 3 46 2.77258872223978 NA 1.67535827725527 2.79893198785693 -1.12357371060166 0.904614110202964 1.03858472991916 1.08742995673211 1.24204751830542 1.08183153307975 0.0743729436763428 NA NA NA 0.155328875095208 92.6452135733775 a929 gain_cnaBRCA19 222 BX-912 PDPK1 (PDK1) 4 45 2.32630161961136 NA 2.59719834690642 3.99814366279989 -1.40094531589347 1.02374408430904 1.49742769626075 0.951887810511365 1.36845266054847 0.935567920502464 0.0744495980445722 NA NA NA 0.0626636862295074 92.6452135733775 a930 CDH1_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 41 1.38629436111989 NA 3.96856794424952 2.72324842686164 1.24531951738788 0.913385557916431 1.48186674074462 0.865109384490518 1.36341056259817 0.840372135460794 0.0745969682824171 NA NA NA 0.0332156052153727 92.6452135733775 a931 MLL3_mut 1007 Docetaxel Microtubules 3 42 -4.38202663467388 NA -3.05966798644927 -4.696394774747 1.63672678829773 2.15805665918914 1.45907597194288 1.09200126678313 0.758426235626598 1.12175570002589 0.0746049783146319 NA NA NA 0.318421362608557 92.6452135733775 a932 gain_cnaBRCA31 253 XMD14-99 EPHB3, CAMK1 16 32 2.32630161961136 NA 5.21314993085691 4.79307779490601 0.420072135950899 0.721025457997606 0.766892432315193 0.558425993443474 0.582603750382825 0.54775887497381 0.0746811307377319 NA NA NA 0.071787906401602 92.6452135733775 a933 gain_cnaBRCA63 34 Imatinib ABL, KIT, PDGFR 3 11 0.693147180559945 NA 2.35325048526801 2.89307864735248 -0.539828162084472 0.468109125961428 0.415679914904205 1.27057958891993 1.15321007890146 1.29866308842196 0.0748338624150441 NA NA NA 0.169977525855425 92.6452135733775 a934 gain_cnaBRCA62 275 I-BET BRD2, BRD3, BRD4 10 39 2.99573227355399 NA 3.35876090105204 4.21334622812146 -0.854585327069424 1.39515039624339 1.30588668731921 0.645727444091357 0.612539930727538 0.654410015331237 0.0748635766564122 NA NA NA 0.103008206157916 92.6452135733775 a935 loss_cnaBRCA38 265 Tubastatin A HDAC6 4 45 2.99573227355399 NA 3.8121327811034 4.76994853440247 -0.957815753299069 0.522632245085606 1.03256660391041 0.950443422748063 1.83267634614122 0.927606751633986 0.0748758947635629 NA NA NA 0.0226350077662027 92.6452135733775 a936 loss_cnaBRCA7_(FAS,PTEN) 286 KIN001-236 TIE2 4 45 2.32630161961136 NA 5.19174239338108 4.4821805774004 0.709561815980678 0.323606606600013 0.767227304763796 0.950102938404468 2.19266789215374 0.924839107751943 0.0749766844820323 NA NA NA 0.0098113392916253 92.6452135733775 a937 PIK3CA_mut 45 Z-LLNle-CHO g-secretase 4 8 0.940007258491471 NA 2.05923636231503 0.432665295655899 1.62657106665913 1.98963416672097 0.927145951036715 1.21598967797059 0.817522685258169 1.75438512657077 0.0751562260488898 NA NA NA 0.201713213269689 92.6452135733775 a938 loss_cnaBRCA57 262 VX-11e ERK 5 44 1.63315443905142 NA 4.775135586157 3.66336607624508 1.11176950991193 0.269350769911007 1.35216568105835 0.858024111618698 4.127589872044 0.822213967922731 0.0754285024759451 NA NA NA 4.28142611577119e-05 92.6452135733775 a939 gain_cnaBRCA58_(CCND1) 201 Epothilone B Microtubules 9 39 -3.44201937618241 NA -3.27624022914467 -4.4571850853027 1.18094485615803 1.18971893796231 1.85353808701829 0.672439916212215 0.992625080156064 0.637130072712864 0.075519487245233 NA NA NA 0.0281607926817118 92.6452135733775 a940 gain_cnaBRCA31 29 AZ628 BRAF 4 10 1.38629436111989 NA 4.0018725138155 1.87977359392525 2.12209891989026 0.522488941271537 2.10802247872732 1.1506890559268 4.061519301683 1.00667755742882 0.0755806948947264 NA NA NA 0.0126730212316221 92.6452135733775 a941 PIK3CA_mut 283 GSK2126458 PI3K, MTOR 16 32 -2.05572501506252 0.0237165266173161 -3.64532549854924 -2.760374106736 -0.884951391813237 1.84754233116996 1.44959963525993 0.556453347338863 0.478988425262678 0.610479866500903 0.0756777748290116 NA NA NA 0.10656212071573 92.6452135733775 a942 loss_cnaBRCA57 301 PHA-793887 CDK-pan 5 43 2.32630161961136 NA 4.15133091226669 2.77935583566752 1.37197507659917 1.18624697983207 1.63162699531224 0.858646719660934 1.15656781422819 0.84086318781249 0.0756973018409349 NA NA NA 0.0582592984903637 92.6452135733775 a943 gain_cnaBRCA31 190 Bleomycin DNA damage 16 32 4.15888308335967 NA 3.06839119732228 1.58340313583299 1.48498806148929 2.79631307392872 2.60707536409335 0.556121715117278 0.531052146962547 0.569599207580143 0.0758464220011164 NA NA NA 0.0869153261117388 92.6452135733775 a944 gain_cnaBRCA12_(TERT) 1067 CCT007093 PPM1D 10 36 1.88706964903238 NA 4.57287048314483 3.95029337411777 0.622577109027061 0.504999462127989 1.04332125399051 0.649776973067886 1.23282727154524 0.596726182511685 0.0759136380767655 NA NA NA 0.0128637433397582 92.6452135733775 a945 gain_cnaBRCA8_(CHD4,WNK1) 256 JW-7-24-1 LCK 4 44 2.32630161961136 NA 0.853076755108997 1.92706843532428 -1.07399168021529 1.15725841465756 1.13103799558366 0.948113894518527 0.928048279115849 0.949562865623327 0.0759690102713989 NA NA NA 0.158819928647304 92.6452135733775 a946 loss_cnaBRCA23 173 FH535 unknown 3 45 3.46573590279973 NA 0.308453592007458 1.65730103540992 -1.34884744340246 0.271350911105298 1.27268192445184 1.0825483423401 4.97086019688744 1.05984646869517 0.0759707466551272 NA NA NA 0.000186207451314878 92.6452135733775 a947 gain_cnaBRCA10_(MDM2,NUP107) 298 OSI-930 KIT, VEGFR, PDGFR 5 43 2.32630161961136 NA 4.56678916596268 3.83738800928869 0.729401156673992 0.39178397460543 0.88190686331794 0.857540111650659 1.86174321552733 0.827072774929786 0.076062449374643 NA NA NA 0.00822305122028037 92.6452135733775 a948 loss_cnaBRCA33 219 AT-7519 CDK9 6 43 2.32630161961136 NA 0.448184672506068 1.84276550302121 -1.39458083051514 1.33328214603748 1.80939036359089 0.79019512190948 1.04597577839007 0.770746246126501 0.0761892548183043 NA NA NA 0.0523003518076613 92.6452135733775 a949 gain_cnaBRCA30_(CRNKL1,FOXA2) 1067 CCT007093 PPM1D 5 41 1.88706964903238 NA 4.81946073281686 3.99614543013667 0.82331530268019 0.641346984654715 0.984386279425566 0.859151639858608 1.28372834421829 0.836374215984229 0.0765459517174795 NA NA NA 0.041331749019664 92.6452135733775 a950 loss_cnaBRCA33 1010 Gefitinib EGFR 5 40 -0.693147180559945 NA 0.625763534459566 1.49666459970609 -0.87090106524652 0.896732748335468 1.02321462251477 0.860475655079847 0.971193554448751 0.851142122173837 0.0766529001290677 NA NA NA 0.0959947893367917 92.6452135733775 a951 CDH1_mut 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 5 41 0 NA 2.18560751561039 0.466338027105713 1.71926948850467 1.19404970682956 2.06607634084632 0.858538182358522 1.43986425244362 0.832142285604224 0.0767490519597552 NA NA NA 0.0269284036957998 92.6452135733775 a952 CDH1_mut 193 GW-2580 CSF1R (cFMS) 4 44 2.99573227355399 NA 4.83414872533486 5.52059251681816 -0.686443791483295 0.658232095093809 0.730499084025524 0.94550792907792 1.04285980066874 0.93969151569711 0.0767511531066145 NA NA NA 0.124674005965424 92.6452135733775 a953 loss_cnaBRCA29_(MAP2K4) 1031 Elesclomol HSP70 6 38 -1.6094379124341 NA -1.78467169311836 -3.16593286701059 1.38126117389223 0.791659715203695 1.82382982946947 0.796811664342979 1.74476627693103 0.757341036742459 0.076852514828336 NA NA NA 0.00639110023470281 92.6452135733775 a954 gain_cnaBRCA16 1025 SB 216763 GSK3A, GSK3B 13 26 2.30258509299405 NA 5.20273113568527 4.73237643202395 0.470354703661326 0.733640438824821 0.7735195920759 0.618224899508316 0.641124287552581 0.608070834248725 0.0768557531130949 NA NA NA 0.0755476066139256 92.6452135733775 a955 gain_cnaBRCA31 71 Pyrimethamine Dihydrofolate reductase (DHFR) 4 10 2.99573227355399 NA 5.3076089982452 4.27433538031379 1.03327361793141 0.24161800989673 1.03285776306101 1.14477156214671 4.27647598940595 1.00040262549722 0.0769078311902392 NA NA NA 0.0127971135831763 92.6452135733775 a956 POLR2B_mut 1047 Nutlin-3a MDM2 3 40 2.07944154167984 1.38629436111989 3.22153900349593 4.28084998540077 -1.05931098190484 1.10357286646126 0.968263406027949 1.08613917126264 0.959892195702176 1.09403182575121 0.0769321939266124 NA NA NA 0.234157950818982 92.6452135733775 a957 gain_cnaBRCA10_(MDM2,NUP107) 277 ABT-869 VEGFR and PDGFR family 5 43 0.0237165266173161 NA 3.04554302844288 2.64986141298073 0.395681615462149 0.343136859928351 0.472681204918592 0.854866051496259 1.15313060667621 0.837100378320091 0.0769509386849382 NA NA NA 0.0588182438472891 92.6452135733775 a958 loss_cnaBRCA29_(MAP2K4) 157 JNK-9L JNK 7 40 1.63315443905142 NA 0.704185491890222 -0.0576154111352217 0.761800903025443 1.23227944524127 0.991890662242577 0.741630015913168 0.618204666130977 0.768029110489939 0.0769514213855203 NA NA NA 0.162624105177282 92.6452135733775 a959 CDH1_mut 274 PXD101, Belinostat HDAC 4 44 2.99573227355399 NA -0.589480208653727 0.786138214567649 -1.37561842322138 1.67809759744094 1.43941101934929 0.944682181257539 0.819748759141996 0.955681459103493 0.0770003995789649 NA NA NA 0.19963448744905 92.6452135733775 a960 gain_cnaBRCA47_(EGFR) 158 PF-562271 FAK 7 38 0.940007258491471 NA 1.54518922894276 2.47841933282417 -0.933230103881408 0.977321059417786 1.29153537891823 0.745133803505795 0.954885904574036 0.722574169561712 0.0770318930631764 NA NA NA 0.0518834236709891 92.6452135733775 a961 loss_cnaBRCA17 1529 MLN4924 NEDD8-activating enzyme 9 28 0 NA 1.2355369848413 0.090754721906011 1.14478226293529 1.52567396613363 1.67279218335779 0.697898015593448 0.750345282377989 0.684354144121697 0.0771117491500311 NA NA NA 0.0755636313752671 92.6452135733775 a962 POLR2B_mut 203 BMS-345541 IKBKB 3 46 2.77258872223978 NA 2.53955610753305 3.597078408779 -1.05752230124595 0.893627416340039 0.985893093294899 1.0767492940738 1.18340404726744 1.0726541330274 0.0771672800951682 NA NA NA 0.168905561270009 92.6452135733775 a963 gain_cnaBRCA62 1006 Cytarabine DNA synthesis 8 37 0.693147180559945 NA 2.07057661392001 1.02214552579375 1.04843108812626 1.94421036521834 1.37838080974552 0.705892817872105 0.539258048862688 0.760625134007651 0.077222589710615 NA NA NA 0.182979496870036 92.6452135733775 a964 POLR2B_mut 1025 SB 216763 GSK3A, GSK3B 3 36 2.30258509299405 NA 4.12200777385484 4.95309079652685 -0.831083022672011 0.914923871911683 0.751142646423712 1.09224042251043 0.908363032364112 1.10642502676277 0.0772306004545254 NA NA NA 0.252842379426056 92.6452135733775 a965 loss_cnaBRCA57 133 Doxorubicin DNA intercalating 5 43 0.0237165266173161 NA 0.335214506699644 -1.18946585449134 1.52468036119098 0.962312408481902 1.84621387243931 0.853304159897918 1.58439229064524 0.825841677365635 0.0774739265754433 NA NA NA 0.01797360207837 92.6452135733775 a966 ASH1L_mut 294 MPS-1-IN-1 MPS1 3 46 2.99573227355399 NA 3.60333856617891 4.83172503796127 -1.22838647178236 1.3135757827259 1.13394040679676 1.07549407510748 0.935147014687839 1.08329014859996 0.0775014038147553 NA NA NA 0.243370009806238 92.6452135733775 a967 gain_cnaBRCA58_(CCND1) 295 NVP-BHG712 EPHB4 10 39 2.32630161961136 NA 4.49632742109261 3.73039564492679 0.76593177616582 1.01432328717607 1.23667983746913 0.639714845146878 0.755116032382749 0.61934524438702 0.0775204460694426 NA NA NA 0.0584944947367193 92.6452135733775 a968 gain_cnaBRCA10_(MDM2,NUP107) 151 QS11 ARFGAP 4 44 2.32630161961136 NA 5.00643489370057 3.64717852903332 1.35925636466725 0.542006306109614 1.48439737427556 0.942725791834782 2.5078238930902 0.915695748472086 0.0775936430064716 NA NA NA 0.00451829512912582 92.6452135733775 a969 gain_cnaBRCA47_(EGFR) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 36 1.38629436111989 0.693147180559945 2.74018357474005 3.54897082575693 -0.808787251016878 1.35994944198587 0.952702710338301 0.798718975518824 0.594718616771401 0.848939802774026 0.0776045999467698 NA NA NA 0.212115549164646 92.6452135733775 a970 gain_cnaBRCA31 279 BIX02189 MAP2K5 (MEK5) 16 33 2.99573227355399 NA 5.3518365364636 4.87003216967573 0.481804366787866 0.777847419197288 0.919590837724527 0.549473991148663 0.619407296208647 0.52393341366913 0.0776887292679267 NA NA NA 0.0640365680196361 92.6452135733775 a971 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 330 XMD13-2 RIPK 5 43 2.32630161961136 NA 2.81619639857929 3.82623343569185 -1.01003703711255 1.30543817177707 1.17241380277928 0.852658239384355 0.773714955598092 0.86150217160374 0.077691080732144 NA NA NA 0.161649946075325 92.6452135733775 a972 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 14 33 0.940007258491471 NA 1.39602735178747 2.09765381995903 -0.701626468171562 1.19146334503541 1.2310328645225 0.575229302127444 0.588877929896123 0.56994942084159 0.0780091575569872 NA NA NA 0.0793537143514797 92.6689257893903 a973 gain_cnaBRCA27_(CLTC,PPM1D) 308 XL-880 MET 9 40 1.63315443905142 NA 2.6956311049739 1.65695127703303 1.03867982794087 1.61574073598466 1.55221074252222 0.664454563318056 0.642850554428762 0.669161602536716 0.0781176346383586 NA NA NA 0.105695789037219 92.6689257893903 a974 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 288 KIN001-055 JAK3, MNK1 6 43 2.32630161961136 NA 3.76505266460381 4.41909363962821 -0.654040975024393 1.13833635027165 0.789200033708473 0.78485758091891 0.574558630995412 0.828739162555577 0.0781281351815157 NA NA NA 0.224518183256674 92.6689257893903 a975 TP53_mut 1036 PLX4720 BRAF 34 9 2.30258509299405 NA 4.76194874687762 3.97202409046235 0.789924656415263 0.824343244310507 2.04369418286684 0.676879322028057 0.958247261522678 0.386518033391463 0.0783162101355788 NA NA NA 0.286532322102129 92.6689257893903 a976 gain_cnaBRCA16 1199 Tamoxifen ER 16 31 1.6094379124341 NA 4.2084173712045 3.69407491962951 0.514342451574981 0.885934632871106 0.947806152448454 0.554462859048587 0.580564787165073 0.542666293362084 0.078372802600238 NA NA NA 0.0747812260131857 92.6689257893903 a977 loss_cnaBRCA36_(FAT1,IRF2) 1219 PFI-1 BRD2, BRD3, BRD4 9 38 2.30258509299405 NA 2.64830717442619 3.29662750959743 -0.648320335171233 0.68792573383423 1.02227337414813 0.667489076729656 0.9424277989395 0.634194679785617 0.0784764222496602 NA NA NA 0.0346037005693093 92.6689257893903 a978 loss_cnaBRCA33 184 BMS-754807 IGF1R 6 42 0.940007258491471 NA 0.503569389615861 1.78734032111759 -1.28377093150173 1.17187457252743 1.68254236756165 0.785286370123157 1.09548492782207 0.762994713388515 0.078530190568516 NA NA NA 0.0450012407150234 92.6689257893903 a979 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1166 QL-VIII-58 MTOR, ATR 5 21 2.30258509299405 NA -2.30580339592955 -1.33169937769023 -0.97410401823932 0.638290692516033 1.13210722852487 0.913953644945716 1.52611346156336 0.860434412655922 0.0786748681435764 NA NA NA 0.0255723629747777 92.6689257893903 a980 gain_cnaBRCA9_(KRAS) 310 YM201636 FYV1 4 45 1.63315443905142 NA 1.5612906785967 2.49052319981746 -0.929232521220765 0.9797196146101 0.991843718769137 0.937601296118005 0.948467814018986 0.936873928459141 0.0787573434101355 NA NA NA 0.152124785162978 92.6689257893903 a981 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 51 Dasatinib ABL, SRC, KIT, PDGFR 3 9 0.246860077931526 NA 2.9429954184362 1.63948224648225 1.30351317195395 0.107354417895835 1.11556420408352 1.30488938878693 12.1421474542272 1.1684788443215 0.0787840360937401 NA NA NA 0.00794194771662749 92.6689257893903 a982 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1069 EHT 1864 Rac GTPases 5 41 2.30258509299405 NA 4.1959316582443 3.48404242865029 0.711889229594006 0.744332320902166 0.843963316922196 0.852156695447419 0.956413163318184 0.843507312841696 0.0788888734578879 NA NA NA 0.0998272783980177 92.6689257893903 a983 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1038 NU-7441 PRKDC (DNAPK) 15 28 0.693147180559945 NA 3.23722672403161 2.70838552905217 0.528841194979439 0.803663908717362 0.970873009167588 0.576575357127802 0.658037755886616 0.544706866897927 0.0789066872428672 NA NA NA 0.0647606060421233 92.6689257893903 a984 loss_cnaBRCA17 1011 ABT-263 BCL2, BCL2L1, BCL2L2 6 37 0.693147180559945 NA 0.575178938792008 1.86142292697717 -1.28624398818516 2.35779168084719 1.49183581924978 0.792813811608667 0.545529106168953 0.862188701724554 0.0789950394771527 NA NA NA 0.245605073922638 92.6689257893903 a985 gain_cnaBRCA14_(RAD21) 104 Bortezomib Proteasome 6 8 -3.91202300542815 NA -5.51399343278862 -3.86525527436665 -1.64873815842197 1.28096013801644 1.78015550914026 1.03609270296099 1.2871112140734 0.926176477255205 0.0791502860721712 NA NA NA 0.0668929129411834 92.6689257893903 a986 gain_cnaBRCA48 255 CP724714 ERBB2 5 43 2.32630161961136 NA 5.03732627340961 3.65951352380214 1.37781274960746 0.300158256715799 1.69844960794156 0.847709147999463 4.59028768584576 0.811217914953218 0.0793719787599113 NA NA NA 3.07083164728768e-05 92.6689257893903 a987 gain_cnaBRCA27_(CLTC,PPM1D) 194 AUY922 HSP90 9 38 -1.36257783450257 NA -3.29853317429561 -2.17945563019857 -1.11907754409703 1.23166663085699 1.76408484098649 0.665405847346902 0.908588018917414 0.634367190339461 0.0793809541529239 NA NA NA 0.0392067681697494 92.6689257893903 a988 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 134 Etoposide TOP2 5 42 2.77258872223978 NA 0.882937896366072 2.66688310174462 -1.78394520537855 2.02810599929778 2.10900565108794 0.848713400907319 0.8796114236614 0.845870282262303 0.079534088902901 NA NA NA 0.122332884321428 92.6689257893903 a989 loss_cnaBRCA28_(GPS2) 1058 GDC0941 PI3K (class 1) 3 40 1.38629436111989 0.693147180559945 2.69388262033973 1.24491156573587 1.44897105460386 0.423991591520831 1.37701417995942 1.07628611968011 3.41745233533168 1.05225572524356 0.079547123615659 NA NA NA 0.00409281324796317 92.6689257893903 a990 gain_cnaBRCA16 1059 AZD8055 MTORC1/2 14 29 0.693147180559945 NA 0.516506369454314 -0.0559506077738432 0.572456977228157 0.680692881744055 1.08937880751268 0.58506208190217 0.840991572824181 0.525489364471129 0.0795827424164248 NA NA NA 0.0420329400350681 92.6689257893903 a991 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 291 KIN001-266 MAP3K8 (COT) 6 43 2.99573227355399 NA 2.99062954794124 3.8885885756158 -0.897959027674562 0.909220724994237 1.17542466720957 0.780808287261338 0.987613901652158 0.7639443451585 0.0796265660204736 NA NA NA 0.0629774326084592 92.6689257893903 a992 PIK3CA_mut 1066 AZD6482 PI3Kbeta 15 28 1.6094379124341 NA 1.44419934761943 2.24735993638674 -0.803160588767304 1.48207123004991 1.35033195044611 0.575035883271235 0.54191767067785 0.594787517618882 0.0796797697881045 NA NA NA 0.0923631602045412 92.6689257893903 a993 gain_cnaBRCA58_(CCND1) 205 BMS-708163 g-secretase 10 38 2.32630161961136 0.940007258491471 5.23007221401626 4.80875512383104 0.42131709018522 0.622422820747568 0.670622541181134 0.63694195363837 0.676898526437692 0.628247731493152 0.0796897056825961 NA NA NA 0.0806296613046862 92.6689257893903 a994 gain_cnaBRCA63 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 6 39 -0.669430653942629 NA -1.87371193392953 -3.73426526811568 1.86055333418615 3.33062013752754 2.20528089212305 0.787095303373642 0.558620694453411 0.843680884748871 0.0797083332672941 NA NA NA 0.236044713200345 92.6689257893903 a995 gain_cnaBRCA63 1243 piperlongumine Increases ROS levels 6 41 2.30258509299405 NA 2.27829605177455 1.62711806842051 0.651177983354038 1.16762406766291 0.778770411191398 0.783597356216842 0.557694896318317 0.836161690269969 0.0797418210441615 NA NA NA 0.236483483589468 92.6689257893903 a996 loss_cnaBRCA57 178 BAY 61-3606 SYK 5 43 2.07944154167984 NA 4.28248588071933 2.9577606054907 1.32472527522862 1.36407301411964 1.58286038142512 0.846442762392659 0.97115422819473 0.836918587876914 0.0798069657514696 NA NA NA 0.0958700345976714 92.6689257893903 a997 loss_cnaBRCA17 1149 TW 37 BCL2, BCL2L1 9 34 1.6094379124341 NA 0.501854556459682 -0.312918041981696 0.814772598441378 1.53242329296583 1.11922408250704 0.672826123782244 0.531688993622957 0.727979866745095 0.0800514947890968 NA NA NA 0.165194083444415 92.6689257893903 a998 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 293 MP470 PDGFR 6 42 2.99573227355399 NA 4.64340512879966 3.37275375356736 1.27065137523231 1.36130874660387 1.65604155177626 0.781172857109194 0.933404254106401 0.767282302711196 0.080055056214816 NA NA NA 0.0747628001636248 92.6689257893903 a999 gain_cnaBRCA47_(EGFR) 201 Epothilone B Microtubules 7 41 -3.44201937618241 NA -5.33459428823989 -4.0481517163763 -1.28644257186359 1.31014500358482 1.81576849150971 0.731729975224147 0.981908543209815 0.708483806101286 0.0801596988326464 NA NA NA 0.0468233629434127 92.6689257893903 a1000 gain_cnaBRCA15 1024 CEP-701 FLT3, JAK2, NTRK1, RET 21 24 0.693147180559945 NA 1.0242865051423 0.276691037417433 0.747595467724869 1.34592674393615 1.4384454913512 0.535459198258142 0.555450340141493 0.519724572269066 0.0801730851959949 NA NA NA 0.0788940677482139 92.6689257893903 a1001 gain_cnaBRCA31 201 Epothilone B Microtubules 16 32 -3.44201937618241 NA -3.59386320813658 -4.55670528309132 0.962842074954739 2.04944331175824 1.59821126969171 0.547653252691364 0.469806639408194 0.602449809492625 0.0802614043288685 NA NA NA 0.112655964904951 92.6689257893903 a1002 gain_cnaBRCA31 294 MPS-1-IN-1 MPS1 16 33 2.99573227355399 NA 5.17567066274006 4.55329202548225 0.622378637257808 0.945167608781009 1.22459780397392 0.544577559408639 0.658484941163499 0.508231057771081 0.080283662128949 NA NA NA 0.0579518833197834 92.6689257893903 a1003 loss_cnaBRCA28_(GPS2) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 39 -1.38629436111989 0.693147180559945 1.34065169642415 -0.428614004600614 1.76926570102476 0.158645008593384 1.68801863603254 1.07511047639553 11.1523565519763 1.04813161611959 0.0803083842632734 NA NA NA 3.10913686502736e-07 92.6689257893903 a1004 gain_cnaBRCA27_(CLTC,PPM1D) 1050 ZM-447439 AURKB 9 30 1.38629436111989 0.693147180559945 3.55806528078308 2.68688172179187 0.871183558991205 1.34337596972693 1.25539159615235 0.68331882338823 0.648503158180126 0.693953633002877 0.0803520178707556 NA NA NA 0.107879300817856 92.6689257893903 a1005 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 158 PF-562271 FAK 9 36 0.940007258491471 NA 3.00228176867498 2.16599231477342 0.836289453901565 0.835326360377291 1.33073225182494 0.667175475062054 1.00115295478505 0.628443064151105 0.0804613555700333 NA NA NA 0.0294367604831338 92.7026901637229 a1006 TP53_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 34 9 2.30258509299405 NA 3.9652450656393 3.2185828302402 0.746662235399098 1.09972283734879 1.16109773494045 0.671480300584951 0.678954923950795 0.643065792766701 0.0806347960127283 NA NA NA 0.108283292842369 92.8101692874136 a1007 TP53_mut 62 BMS-536924 IGF1R 9 3 1.63315443905142 NA 3.46365760833105 2.2671790325525 1.19647857577855 0.948321717215086 0.818904179875443 1.29504490423287 1.26168003332479 1.46107274230855 0.0807368395974478 NA NA NA 0.103414935878289 92.8353391955162 a1008 gain_cnaBRCA31 204 Tipifarnib Farnesyl-transferase (FNTA) 16 32 2.77258872223978 NA 2.15726714206715 1.35133122021841 0.805935921848738 2.09356838989576 1.05312373622833 0.546266695402075 0.384958010322685 0.765281318921864 0.0810044393856622 NA NA NA 0.163243138156016 92.9605650832816 a1009 gain_cnaBRCA63 1072 BMS-708163 g-secretase 6 40 1.6094379124341 NA 4.31605958888734 3.58947829591545 0.726581292971892 1.38380643428763 0.853846607218798 0.78176227262496 0.525059918041158 0.850950612005776 0.0810459261276751 NA NA NA 0.260816695272728 92.9605650832816 a1010 loss_cnaBRCA36_(FAT1,IRF2) 303 PIK-93 PI4K, PI3K 9 40 2.99573227355399 NA 3.53535458608845 2.62416603772289 0.911188548365555 1.77295618641942 1.29296138399614 0.65721070174232 0.513937431361883 0.704729901174121 0.0813119827006444 NA NA NA 0.175764106754637 92.9605650832816 a1011 loss_cnaBRCA24 1170 CCT018159 HSP90 3 40 2.30258509299405 NA 4.49431679055713 3.25646678173414 1.23785000882299 1.09109513763045 1.16044947097915 1.06972850790865 1.13450236018029 1.06669875748966 0.0813286768385433 NA NA NA 0.18043338086368 92.9605650832816 a1012 gain_cnaBRCA64_(SDHC) 1239 YK 4-279 RNA helicase A 8 34 2.30258509299405 NA 2.72823550090677 1.84539226350057 0.882843237406199 1.89242878678131 1.07442785811154 0.702552216547888 0.466513320645349 0.821686845460171 0.0813729393184382 NA NA NA 0.23866094146855 92.9605650832816 a1013 CDH1_mut 286 KIN001-236 TIE2 4 45 2.32630161961136 NA 3.9022235290262 4.59680447645417 -0.694580947427961 0.871527610585373 0.738746103905822 0.928675826916513 0.796969526830523 0.940216054955342 0.0815534077244132 NA NA NA 0.209505346124006 92.9605650832816 a1014 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 197 Bryostatin 1 PRKC 7 41 -4.8283137373023 NA -2.22102575590158 -2.90681482968381 0.685789073782228 1.08961470179617 0.917621979141525 0.728138570007783 0.629386766397095 0.747354672589483 0.0816043350183423 NA NA NA 0.156805614613568 92.9605650832816 a1015 gain_cnaBRCA61_(NOTCH2) 263 FR-180204 ERK 3 46 2.99573227355399 NA 4.64633125386145 5.4042905612507 -0.757959307389248 1.57114874913331 0.651218291542688 1.06023125003272 0.4824236456334 1.16390973231679 0.0816623720395333 NA NA NA 0.491742378090433 92.9605650832816 a1016 gain_cnaBRCA8_(CHD4,WNK1) 1527 GDC0941 (rescreen) PI3K 3 42 1.38629436111989 NA 2.09892934783233 0.900779162330135 1.1981501855022 2.14213945742049 1.05013330893338 1.06531971207627 0.559324081983429 1.14095055866684 0.081709159111487 NA NA NA 0.435209294070279 92.9605650832816 a1017 loss_cnaBRCA17 200 LAQ824 HDAC 11 37 0.0237165266173161 NA -3.33214659041659 -2.49191413999721 -0.840232450419375 0.864316347893126 1.48595222275213 0.611107582253825 0.972135321132757 0.56545051553756 0.0817675726214018 NA NA NA 0.0256422966467939 92.9605650832816 a1018 ASH1L_mut 1495 AZD-2281 PARP1, PARP2 3 42 2.30258509299405 NA 2.90603147194114 4.07673842731348 -1.17070695537234 1.41514106229579 1.08140750340824 1.06507382093151 0.827272267453745 1.0825770596955 0.0817771854013919 NA NA NA 0.286343636443472 92.9605650832816 a1019 BRCA2_mut 1016 Temsirolimus MTOR 5 39 -1.6094379124341 NA -0.657291478398914 -1.891152431002 1.23386095260309 1.04574901374994 1.49349342672471 0.846971161447948 1.17988249224219 0.82615760506492 0.0818091508937421 NA NA NA 0.055008910964586 92.9605650832816 a1020 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 15 33 2.07944154167984 NA 2.78356265685287 3.41009472079963 -0.626532063946755 1.19884259890691 1.10095427926509 0.553648112206781 0.522614115079007 0.569080910757693 0.0820252363172151 NA NA NA 0.0975356411583981 93.1147265997092 a1021 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 272 AR-42 HDAC 15 34 1.63315443905142 NA -0.428162635340318 0.393497115447541 -0.821659750787858 1.12086268749301 1.6241858877304 0.550665580374079 0.733060133017395 0.505890216751007 0.0821168705778931 NA NA NA 0.0477495373990621 93.1274480334402 a1022 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 18 29 2.99573227355399 NA 3.39019432298174 4.1316080379176 -0.741413714935858 1.20889827926497 1.49031211417069 0.533119162657658 0.613297022299221 0.497488886982865 0.0823804015368773 NA NA NA 0.0690115421695627 93.2792020019881 a1023 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1006 Cytarabine DNA synthesis 8 37 0.693147180559945 NA 2.05637838793779 1.02521541249261 1.03116297544518 1.99618316673786 1.36626285675968 0.693403642894647 0.516567313374502 0.754732495539518 0.0824118003696639 NA NA NA 0.19929622922267 93.2792020019881 a1024 gain_cnaBRCA10_(MDM2,NUP107) 1054 PD-0332991 CDK4, CDK6 3 39 1.38629436111989 0.693147180559945 1.47359537196769 2.99131315111172 -1.51771777914404 0.812656887612111 1.44805320566896 1.06653392685373 1.86759972416361 1.04810912555032 0.0826580659014964 NA NA NA 0.0603894066935156 93.3550039571623 a1025 loss_cnaBRCA18 200 LAQ824 HDAC 16 32 0.0237165266173161 NA -3.18239895573858 -2.43550163695819 -0.746897318780385 0.808076051159987 1.57808908692253 0.543112583445396 0.924290873004119 0.473292239943772 0.0827161806972543 NA NA NA 0.0353381166632229 93.3550039571623 a1026 loss_cnaBRCA20 1042 BIRB 0796 p38, JNK2 3 40 2.30258509299405 NA 5.25566042294689 4.29991568948331 0.955744733463585 0.259674006788746 0.918542388304543 1.06466794527942 3.68055603748248 1.04050150067403 0.0827263634764198 NA NA NA 0.00237760626700083 93.3550039571623 a1027 gain_cnaBRCA31 119 Lapatinib ERBB2, EGFR 4 9 0.693147180559945 NA -0.156399949529462 2.15273471985596 -2.30913466938542 2.09891675370542 1.9810615320039 1.14660531612922 1.10015543270541 1.16560471852162 0.0828115126515299 NA NA NA 0.116100166774828 93.3550039571623 a1028 loss_cnaBRCA23 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 3 43 2.30258509299405 NA 2.37303247591001 1.34620810873003 1.02682436717998 0.316098159989914 0.989370506098911 1.05970735812234 3.24843512917868 1.03785625390103 0.0828818931409991 NA NA NA 0.00587775700795706 93.3550039571623 a1029 loss_cnaBRCA57 328 SNX-2112 HSP90 5 43 0.940007258491471 NA 1.90878315106286 0.243804701607827 1.66497844945503 1.65739080297257 2.01730709403519 0.837262602693805 1.00457806720591 0.825347045265481 0.0830204193975286 NA NA NA 0.0877622165505571 93.4201590091335 a1030 PIK3CA_mut 346 THZ-2-102-1 CDK7 16 32 0.916290731874155 2.99573227355399 -0.438325731216138 -1.78357359241013 1.34524786119399 2.74187056184429 2.34389125626179 0.54228722619193 0.490631425098756 0.573937829922831 0.0831690691419839 NA NA NA 0.10490648731503 93.4535463206038 a1031 loss_cnaBRCA22_(SYNCRIP,ZNF292) 253 XMD14-99 EPHB3, CAMK1 18 30 2.32630161961136 NA 5.18180635027717 4.78387913419046 0.397927216086709 0.630798774964165 0.817195419560229 0.52796566973517 0.630830673552457 0.486942543438205 0.0832115089874277 NA NA NA 0.0656292920906931 93.4535463206038 a1032 PIK3CA_mut 1166 QL-VIII-58 MTOR, ATR 10 16 2.30258509299405 NA -1.99764017146385 -1.21989388728151 -0.777746284182335 0.963939618333991 1.12575881314764 0.728258331675526 0.806841289007853 0.690864042190123 0.0833825043849842 NA NA NA 0.07449123906355 93.4642130599418 a1033 loss_cnaBRCA33 1375 Temozolomide DNA akylating agent 5 41 3.40119738166216 NA 5.39189738268697 5.96210502721283 -0.570207644525854 0.53432009674585 0.692649764340673 0.838809922348844 1.0671648848669 0.823226504766994 0.0835268233961089 NA NA NA 0.0743682797836023 93.4642130599418 a1034 gain_cnaBRCA62 208 SB-715992 KIF11 10 39 -2.05572501506252 NA -2.07099368813227 -1.02679815419134 -1.04419553394093 2.47405878243875 1.40858303395083 0.626687316087205 0.422057689717315 0.741309180057456 0.0835497538713472 NA NA NA 0.227174846507241 93.4642130599418 a1035 gain_cnaBRCA19 186 Bexarotene Retinioic acid X family agonist 4 43 2.07944154167984 NA 2.66423184983154 3.69186347268461 -1.02763162285307 1.95536745713813 1.02435705256345 0.924987183460513 0.525543993842011 1.00319670790709 0.083586376521387 NA NA NA 0.372212784442077 93.4642130599418 a1036 gain_cnaBRCA12_(TERT) 1129 PF-4708671 RPS6KB1 (p70S6KA) 10 33 2.30258509299405 NA 4.35547648076873 3.64335796655184 0.712118514216886 0.63671286383246 1.21349181739687 0.639938069000451 1.1184296009516 0.586834211823936 0.0836909528277761 NA NA NA 0.0208835619784793 93.4642130599418 a1037 gain_cnaBRCA63 1006 Cytarabine DNA synthesis 6 39 0.693147180559945 NA 2.20948452140563 1.05454077531526 1.15494374609037 2.27796924688591 1.3495190156319 0.776403555210163 0.507005855179665 0.855818801152333 0.0837377726429038 NA NA NA 0.275374299740466 93.4642130599418 a1038 NF1_mut 287 KIN001-244 PDPK1 (PDK1) 5 44 2.99573227355399 NA 4.16655062900295 3.3998737024088 0.766676926594144 0.594765998084488 0.944294770619483 0.833585824105507 1.28903960391703 0.811904238430955 0.0838404643176861 NA NA NA 0.0406999029826435 93.4642130599418 a1039 ARID1A_mut 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 5 44 3.68887945411394 NA 4.3320748073291 3.36029768610454 0.971777121224563 1.31412804683394 1.15126553626813 0.833419399216091 0.73948434748487 0.844094685900711 0.0839003351404764 NA NA NA 0.177008185975986 93.4642130599418 a1040 PTEN_mut 1166 QL-VIII-58 MTOR, ATR 4 22 2.30258509299405 NA -2.40478414047046 -1.35798033405731 -1.04680380641315 0.616095393260231 1.11797924373793 0.979953397413932 1.6990937083196 0.93633563617263 0.0839834257381716 NA NA NA 0.0300212928726317 93.4642130599418 a1041 loss_cnaBRCA33 286 KIN001-236 TIE2 6 43 2.32630161961136 NA 4.03493421396981 4.61059279704008 -0.575658583070275 1.10812616377251 0.693149904312513 0.769272168526105 0.51948830547462 0.83049651956777 0.0840281939678724 NA NA NA 0.26505805266588 93.4642130599418 a1042 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 271 VNLG/124 HDAC, RAR 7 42 1.63315443905142 NA 4.64129986751595 4.06979681198314 0.571503055532807 0.973329698303564 0.7634972676005 0.720339147190756 0.587162866322574 0.748533203437534 0.0841520926449003 NA NA NA 0.180919581408257 93.4908221002011 a1043 BRCA1_mut 293 MP470 PDGFR 4 44 2.99573227355399 NA 4.90713054733297 3.40653559621125 1.50059495112172 0.432350556041267 1.68002154286845 0.921705727165953 3.47078297958402 0.893199826806755 0.0842136000090766 NA NA NA 0.000422775238423399 93.4908221002011 a1044 BRCA2_mut 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 40 2.30258509299405 NA 4.12026160002523 3.05894265049274 1.06131894953249 1.30753867508677 1.26359832298222 0.837167352434751 0.811692204409987 0.839917978861886 0.0846817000456955 NA NA NA 0.146748789777654 93.603589787924 a1045 TP53_mut 1053 MK-2206 AKT1, AKT2 33 9 1.38629436111989 0.693147180559945 1.16626825118347 2.22845199226992 -1.06218374108644 1.68402498947525 1.19262589639335 0.664745242956547 0.630741080283744 0.890626091801812 0.0847387775877047 NA NA NA 0.0455572641342966 93.603589787924 a1046 gain_cnaBRCA58_(CCND1) 163 JQ1 BRD4 9 38 0.940007258491471 NA 1.06671552437827 0.138095980948887 0.928619543429387 1.85573395166299 1.30855357797276 0.653354488095634 0.500405536363237 0.709653436482156 0.0847871441361172 NA NA NA 0.18614574432254 93.603589787924 a1047 gain_cnaBRCA12_(TERT) 261 TL-1-85 MAP3K7 (TAK1) 9 40 2.32630161961136 NA 3.3979310316256 4.16585343866405 -0.767922407038449 1.75851779207118 1.02520430218589 0.649359426245574 0.436687311610304 0.749043293518301 0.0848970130545102 NA NA NA 0.237579179069055 93.603589787924 a1048 loss_cnaBRCA17 301 PHA-793887 CDK-pan 10 38 2.32630161961136 NA 2.12911641790179 3.13099450831629 -1.0018780904145 1.80701660608604 1.54690973680603 0.625732449673267 0.554437677573171 0.647664221496927 0.0849540385495445 NA NA NA 0.133008352516335 93.603589787924 a1049 MLL3_mut 221 TAK-715 p38a 3 46 2.99573227355399 2.32630161961136 3.51530743351658 4.54520784087686 -1.02990040736028 0.856711171174658 0.987484561816457 1.04848536690879 1.20215592140366 1.04295342649792 0.0849905211847097 NA NA NA 0.16400654649274 93.603589787924 a1050 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 222 BX-912 PDPK1 (PDK1) 7 42 2.32630161961136 NA 4.79192742000962 3.73242300651318 1.05950441349644 1.52885283021915 1.46716073864187 0.718220435713507 0.693006149810097 0.722146105461636 0.0850395593180531 NA NA NA 0.126383226807266 93.603589787924 a1051 loss_cnaBRCA17 1192 GSK269962A ROCK1, ROCK2 9 37 1.6094379124341 NA 3.41865952949969 2.48533706993597 0.933322459563718 1.13959718185366 1.48199117487625 0.654565166221961 0.818993302568177 0.62977599015841 0.0851615527816484 NA NA NA 0.0559003908884911 93.603589787924 a1052 BRCA2_mut 151 QS11 ARFGAP 6 42 2.32630161961136 NA 2.7903270699603 3.89903886744063 -1.10871179748033 1.28012904391563 1.463009947836 0.76767103284942 0.866093776053251 0.757829295091448 0.0852357605423283 NA NA NA 0.0924394506894921 93.603589787924 a1053 gain_cnaBRCA13_(FGFR1,WHSC1L1) 281 CH5424802 ALK 11 37 1.63315443905142 NA 4.05861145417531 3.4315344879552 0.627076966220109 0.890980985037562 1.07618277747769 0.603693346117882 0.703805105553035 0.582686305099422 0.0854181432462124 NA NA NA 0.0657440022619311 93.603589787924 a1054 MLL3_mut 207 AS601245 JNK 3 45 2.07944154167984 NA 1.03630679360717 2.34819364112005 -1.31188684751288 1.24309919668614 1.25224397273786 1.04796037219506 1.05533560878337 1.04762879764126 0.0854891463515033 NA NA NA 0.203255604397215 93.603589787924 a1055 NF1_mut 1016 Temsirolimus MTOR 4 40 -1.6094379124341 NA -0.527490350632574 -1.87328601996356 1.34579566933099 1.6634186955981 1.44110300484363 0.92297441065983 0.809054072130102 0.933865008127586 0.0856822182817504 NA NA NA 0.204363467405225 93.603589787924 a1056 gain_cnaBRCA31 1218 JQ1 BRD2, BRD3, BRD4 14 32 0 NA 2.72599595110895 2.34072571240035 0.385270238708603 0.663588090449192 0.692414745393821 0.563240629452849 0.580586427414344 0.556415416152749 0.0857477015957303 NA NA NA 0.0855151117811185 93.603589787924 a1057 MLL3_mut 175 PAC-1 CASP3 agonist 3 45 0.940007258491471 NA 1.23105160751433 2.47940381341303 -1.2483522058987 1.32956391783149 1.1860247873378 1.04672659570049 0.938918534984577 1.05255153115375 0.0858462975627746 NA NA NA 0.241773015962024 93.603589787924 a1058 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 293 MP470 PDGFR 14 34 2.99573227355399 NA 2.8887101363183 3.79629842688737 -0.907588290569079 1.9044883948508 1.50618048633233 0.557263988608874 0.476552281979214 0.602576051678327 0.0859411597664416 NA NA NA 0.127477769448734 93.603589787924 a1059 loss_cnaBRCA33 306 TG101348 JAK2 6 42 2.32630161961136 NA 2.38624836032534 3.34469472756166 -0.958446367236327 0.62745657438659 1.3075709264276 0.765730134797343 1.52751027937402 0.73299761249272 0.0860030254867325 NA NA NA 0.0118902607038732 93.603589787924 a1060 gain_cnaBRCA16 1022 AZD7762 CHEK1, CHEK2 15 30 0.693147180559945 NA 1.48996367047733 0.61214419318896 0.877819477288372 1.71926357918732 1.50843603206134 0.55552259189088 0.510578766347921 0.581940141067032 0.0860856049642894 NA NA NA 0.10531437353228 93.603589787924 a1061 loss_cnaBRCA38 328 SNX-2112 HSP90 4 44 0.940007258491471 NA -1.25332160810752 0.569109189929112 -1.82243079803663 1.82816579361729 2.0006997837893 0.91583872893564 0.996862978401261 0.910896683651844 0.0861434798525769 NA NA NA 0.137305273939874 93.603589787924 a1062 gain_cnaBRCA16 1219 PFI-1 BRD2, BRD3, BRD4 16 31 2.30258509299405 NA 3.51857244071708 2.99385325429241 0.524719186424665 1.25260778492659 0.797287209194078 0.539263311156879 0.41890142528167 0.658130696659572 0.0866153774557596 NA NA NA 0.142149856131807 93.603589787924 a1063 gain_cnaBRCA8_(CHD4,WNK1) 1019 Bosutinib SRC, ABL, TEC 3 42 0.693147180559945 NA 1.77291944212383 2.72614704410899 -0.953227601985165 1.05053797181035 0.902285280024778 1.04782913498943 0.90737091620068 1.05645921870629 0.0866679314816341 NA NA NA 0.253381384000093 93.603589787924 a1064 BRCA1_mut 1378 Bleomycin (50 uM) DNA damage 4 44 3.91202300542815 NA 2.27107578201784 3.95286687054817 -1.68179108853033 0.703291077181975 1.89405545457937 0.913998010776754 2.39131583365044 0.887931282299137 0.0867565150438293 NA NA NA 0.00591021691186865 93.603589787924 a1065 gain_cnaBRCA14_(RAD21) 276 CAY10603 HDAC6 21 28 2.99573227355399 NA 0.896571950415869 1.38476559162566 -0.488193641209796 1.05697441873407 0.8968391157121 0.504215386244248 0.461878388499222 0.544349184437796 0.0872302988820663 NA NA NA 0.0960311657425985 93.603589787924 a1066 gain_cnaBRCA63 223 ZSTK474 PI3K 7 42 1.63315443905142 2.32630161961136 0.0485564421269565 1.05630154786679 -1.00774510573984 0.864750980727364 1.47655990875943 0.713053252779942 1.16535873124098 0.682495237586751 0.0872367384194285 NA NA NA 0.0253902388800642 93.603589787924 a1067 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1005 Cisplatin DNA crosslinker 6 39 1.79175946922805 2.30258509299405 4.43582902132139 3.55227655624227 0.883552465079117 1.50849627945107 1.09645786832598 0.766994885982812 0.585717364447616 0.805824364622496 0.0874235657366531 NA NA NA 0.218160693621829 93.603589787924 a1068 gain_cnaBRCA62 238 CAL-101 PI3Kdelta 10 39 2.99573227355399 2.32630161961136 4.26451689797427 4.83548917365196 -0.570972275677689 0.670604518707802 0.973298181666275 0.618570198145895 0.851429210137003 0.586636537941735 0.0875010856449141 NA NA NA 0.0422843383752755 93.603589787924 a1069 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 203 BMS-345541 IKBKB 15 34 2.77258872223978 NA 3.16292050606561 3.69530786868967 -0.532387362624061 0.813100279057175 1.048523084139 0.540877469476907 0.654762243153313 0.507749777451234 0.0875274620481914 NA NA NA 0.0624397360298615 93.603589787924 a1070 gain_cnaBRCA27_(CLTC,PPM1D) 176 IPA-3 PAK1, PAK2, PAK3 8 39 3.46573590279973 NA 3.66883076521467 4.66668738534499 -0.997856620130324 1.76249361901482 1.41207124257276 0.677859317186533 0.566161834213104 0.706661668367563 0.0875479627452645 NA NA NA 0.166743404082161 93.603589787924 a1071 loss_cnaBRCA57 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 5 44 1.63315443905142 NA 4.29854501310341 3.49462415786289 0.803920855240513 0.558494849932907 1.00635397366826 0.823461622358039 1.43944184147283 0.798845015049864 0.0875481574184592 NA NA NA 0.0269507905570501 93.603589787924 a1072 loss_cnaBRCA57 281 CH5424802 ALK 5 43 1.63315443905142 NA 4.34298311420201 3.48596712742467 0.857015986777335 0.359604444248629 1.08188206370921 0.824689324773378 2.38321856274056 0.792152874629486 0.0875966755978448 NA NA NA 0.00200469968010243 93.603589787924 a1073 gain_cnaBRCA19 310 YM201636 FYV1 4 45 1.63315443905142 NA 1.58471536232891 2.48844100570793 -0.903725643379018 0.691181170464394 1.01021237132754 0.910173220997764 1.30750906129549 0.894589760558383 0.0876149080045186 NA NA NA 0.0709867235946343 93.603589787924 a1074 loss_cnaBRCA18 179 5-Fluorouracil DNA antimetabolite 16 33 3.46573590279973 NA 3.47619270090574 4.31555377273188 -0.839361071826133 1.5215614815215 1.60659016476027 0.531257795944131 0.551644532291133 0.52244878017872 0.0877125609920865 NA NA NA 0.085152440570777 93.603589787924 a1075 loss_cnaBRCA23 235 QL-XII-47 BTK, BMX 3 46 2.32630161961136 NA 0.275559722098941 1.80150001043291 -1.52594028833397 1.31596568973842 1.47499888767143 1.03905664504392 1.15955932607733 1.03453656886681 0.0877433559886534 NA NA NA 0.174393274395421 93.603589787924 a1076 gain_cnaBRCA10_(MDM2,NUP107) 341 EX-527 SIRT1 5 44 2.99573227355399 NA 6.11390424948434 5.5880997148499 0.525804534634442 0.231537868353437 0.66440056970577 0.822753243529391 2.27092241270795 0.791396875031722 0.0878126140338766 NA NA NA 0.00266614350147143 93.603589787924 a1077 gain_cnaBRCA62 253 XMD14-99 EPHB3, CAMK1 10 38 2.32630161961136 NA 4.56297854496988 5.03050270739484 -0.467524162424954 1.25298669423811 0.570728775583753 0.619701991575894 0.373127795031564 0.819170475409727 0.087904326432572 NA NA NA 0.277296280522003 93.603589787924 a1078 loss_cnaBRCA17 265 Tubastatin A HDAC6 11 38 2.99573227355399 NA 4.22420017481306 4.82710561183108 -0.602905437018013 0.825932306073842 1.05496977227424 0.596584616983184 0.729969553902049 0.571490722163828 0.0879690133253522 NA NA NA 0.0595109705261546 93.603589787924 a1079 gain_cnaBRCA62 1003 Camptothecin TOP1 8 37 -2.30258509299405 NA -1.66357413373852 -2.71646140301121 1.05288726927269 1.90256238278831 1.46852444009904 0.680379522862267 0.553404860096953 0.716969524321759 0.0881318305619345 NA NA NA 0.17518257883064 93.603589787924 a1080 gain_cnaBRCA30_(CRNKL1,FOXA2) 345 KIN001-270 CDK9 5 44 2.99573227355399 NA 5.60499259905376 5.05106362330426 0.553928975749508 0.869047384181874 0.652929547249124 0.821821668718757 0.63739789778089 0.848374802585182 0.0881614075845448 NA NA NA 0.231355066251136 93.603589787924 a1081 ARID1A_mut 1011 ABT-263 BCL2, BCL2L1, BCL2L2 4 39 0.693147180559945 NA 3.03378158372576 1.54329732297446 1.49048426075129 0.657716384314776 1.67882080912649 0.916658888451321 2.26615042029721 0.887816169926322 0.0883068677495093 NA NA NA 0.00787156541127183 93.603589787924 a1082 gain_cnaBRCA30_(CRNKL1,FOXA2) 1494 SN-38 TOP1 5 43 -2.99573227355399 NA -2.09294756592261 -3.44458396852835 1.35163640260574 2.26410759986575 1.57110863227903 0.822656587033534 0.596984172786615 0.860307412763099 0.0883559113217196 NA NA NA 0.257038376235276 93.603589787924 a1083 loss_cnaBRCA38 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 4 44 2.32630161961136 NA 4.39261686306713 5.00993345260537 -0.617316589538238 0.437919986175861 0.69283012303895 0.90898365983844 1.40965612218104 0.891007144479388 0.0884449755230718 NA NA NA 0.0568670404850531 93.603589787924 a1084 gain_cnaBRCA27_(CLTC,PPM1D) 1006 Cytarabine DNA synthesis 10 35 0.693147180559945 NA 1.93243580629695 1.00170398007884 0.93073182621811 1.16374343933821 1.5639444208695 0.625026379900593 0.799774069400893 0.595118224022728 0.0884609521582081 NA NA NA 0.0537498104603912 93.603589787924 a1085 loss_cnaBRCA57 1011 ABT-263 BCL2, BCL2L1, BCL2L2 5 38 0.693147180559945 NA 0.489963835910461 1.83878691450934 -1.34882307859888 1.83020920692705 1.6025358596196 0.829457090796654 0.736977539777308 0.84168043448279 0.0887312018166603 NA NA NA 0.17895388168508 93.603589787924 a1086 gain_cnaBRCA10_(MDM2,NUP107) 1023 GW 441756 NTRK1 3 42 0.693147180559945 NA 3.59116144764608 2.2712957439839 1.31986570366218 0.195749307320504 1.29812324528132 1.04067563729496 6.74263281811334 1.01674914801803 0.0887672966038779 NA NA NA 7.42406693954306e-06 93.603589787924 a1087 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1 Erlotinib EGFR 4 8 0.693147180559945 NA 3.31662413012887 2.73154682678046 0.585077303348412 0.161636544670217 0.596505381429794 1.15430856315983 3.61970929619989 0.980841617800683 0.0887932660816161 NA NA NA 0.029800847977992 93.603589787924 a1088 loss_cnaBRCA57 255 CP724714 ERBB2 5 43 2.32630161961136 NA 5.00074885538058 3.66376671194505 1.33698214343553 0.555359646836036 1.69580637143935 0.82091249878216 2.40741679928045 0.788404953509368 0.0890116950035973 NA NA NA 0.00189435343831598 93.603589787924 a1089 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 201 Epothilone B Microtubules 9 39 -3.44201937618241 NA -3.31634804986131 -4.44792943436809 1.13158138450678 2.01413342296316 1.70338104846772 0.642444747094977 0.561820469093856 0.664314884520229 0.0890307718940054 NA NA NA 0.147216275781963 93.603589787924 a1090 loss_cnaBRCA17 134 Etoposide TOP2 10 37 2.77258872223978 NA 1.45012139868639 2.75466393968217 -1.30454254099578 1.67175524152151 2.20155357546762 0.619357984703289 0.78034302426262 0.592555437002568 0.0890903369091532 NA NA NA 0.056385046336684 93.603589787924 a1091 PTEN_mut 229 LY317615 PRKCB (PKCbeta) 9 40 2.99573227355399 2.32630161961136 4.1826809199081 3.17316105622759 1.00951986368051 1.38910989053351 1.61179738255292 0.640510886359811 0.726738662333463 0.626331742815919 0.0890945871880483 NA NA NA 0.0778831044702966 93.603589787924 a1092 CDH1_mut 260 NG-25 MAP3K7 (TAK1) 4 45 2.32630161961136 NA 2.16439688098891 3.30113865122523 -1.13674177023632 1.20032740448185 1.25880762050895 0.905657577492107 0.947026424617059 0.903030575694106 0.0891499045950784 NA NA NA 0.152559563581955 93.603589787924 a1093 ARID1A_mut 283 GSK2126458 PI3K, MTOR 5 43 -2.05572501506252 0.0237165266173161 -4.22765420665279 -2.91904438044363 -1.30860982620916 1.76053983993011 1.57833388681477 0.820442781076533 0.743300319895694 0.829108363661924 0.089189001252402 NA NA NA 0.175511871961703 93.603589787924 a1094 CDH1_mut 302 PI-103 PI3Ka, PRKDC (DNAPK) 4 44 2.32630161961136 NA -0.375687913518512 1.2651714387614 -1.64085935227991 0.795244401109169 1.85993302762464 0.906706382411612 2.06333971039761 0.882214213043727 0.0892207788420151 NA NA NA 0.0129441274339826 93.603589787924 a1095 gain_cnaBRCA19 256 JW-7-24-1 LCK 4 44 2.32630161961136 NA 0.893757984915218 1.92337014170554 -1.02961215679032 1.1409208535376 1.13570557351594 0.906311687052125 0.902439598327829 0.906583696338502 0.0893558142295198 NA NA NA 0.16764766280546 93.603589787924 a1096 loss_cnaBRCA18 1016 Temsirolimus MTOR 13 31 -1.6094379124341 NA -1.16018643898536 -1.99867672562139 0.838490286636027 1.66476269737128 1.36851034866798 0.574582414668725 0.503669554802034 0.612702919968535 0.0893756308096385 NA NA NA 0.125296581011895 93.603589787924 a1097 loss_cnaBRCA17 255 CP724714 ERBB2 10 38 2.32630161961136 NA 4.5982911440061 3.59375793290735 1.00453321109875 0.48373244530154 1.80035741592432 0.616742005080156 2.07662979991463 0.557963214533718 0.0893833841630851 NA NA NA 0.00382656040363739 93.603589787924 a1098 loss_cnaBRCA33 230 GSK429286A ROCK2 6 43 2.99573227355399 2.32630161961136 4.82438914202639 5.48658932238605 -0.662200180359665 0.853435676237468 0.878745117118478 0.755860883884584 0.775922777542063 0.753574805093777 0.0893989613863049 NA NA NA 0.122127186020848 93.603589787924 a1099 gain_cnaBRCA31 1371 PLX4720 (rescreen) BRAF 15 32 2.30258509299405 NA 5.05223289720448 4.54538849060966 0.506844406594823 0.679384703112107 1.02732335572165 0.54319253018572 0.746034469532629 0.493364045285224 0.0894243881623388 NA NA NA 0.0515746648802815 93.603589787924 a1100 PTEN_mut 171 AKT inhibitor VIII AKT1, AKT2, AKT3 8 39 0.940007258491471 NA 1.20507187586149 2.02888164043027 -0.82380976456878 0.911403037848711 1.27184074212523 0.673723747495483 0.903891835288714 0.647730283582677 0.0894352838732873 NA NA NA 0.0494514425411142 93.603589787924 a1101 gain_cnaBRCA16 1502 Bicalutamide ANDR (androgen receptor) 15 30 2.30258509299405 NA 4.76649938303144 4.4542050079077 0.312294375123733 0.784253040468987 0.4272203446239 0.549202600376247 0.398206138846435 0.730991346862609 0.0895946046917383 NA NA NA 0.167017438945186 93.603589787924 a1102 loss_cnaBRCA38 303 PIK-93 PI4K, PI3K 4 45 2.99573227355399 NA 1.63827282405677 2.89403869972188 -1.25576587566511 1.85065151870091 1.35157740727093 0.904207988646418 0.67855339753354 0.929111324967118 0.0896473773639737 NA NA NA 0.26936161800224 93.603589787924 a1103 gain_cnaBRCA27_(CLTC,PPM1D) 221 TAK-715 p38a 9 40 2.99573227355399 2.32630161961136 3.96905671305888 4.59759931408388 -0.628542601024999 1.02127160143617 0.975196766107978 0.639287889334006 0.615450973219176 0.644529004678225 0.0896881067556196 NA NA NA 0.119475765671036 93.603589787924 a1104 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1218 JQ1 BRD2, BRD3, BRD4 6 40 0 NA 2.91021203337804 2.39014734780171 0.520064685576325 0.728272726483611 0.678794047586041 0.759665731532484 0.714107046253679 0.766159761456075 0.089705788250087 NA NA NA 0.148103769725494 93.603589787924 a1105 gain_cnaBRCA47_(EGFR) 1022 AZD7762 CHEK1, CHEK2 7 38 0.693147180559945 NA -0.048678356761798 1.08038235132004 -1.12906070808183 0.9223407329403 1.6638784152017 0.713953002131794 1.22412538854544 0.678571641873826 0.0897577353952311 NA NA NA 0.0221587829686432 93.603589787924 a1106 gain_cnaBRCA58_(CCND1) 260 NG-25 MAP3K7 (TAK1) 10 39 2.32630161961136 NA 3.8218099996031 3.05104427777077 0.770765721832339 1.5520598746108 1.17409540445752 0.614003212888792 0.496608239437682 0.656476227490615 0.089791851333518 NA NA NA 0.168703554430541 93.603589787924 a1107 gain_cnaBRCA10_(MDM2,NUP107) 208 SB-715992 KIF11 5 44 -2.05572501506252 NA -0.0154875278221319 -1.3790369830835 1.36354945526137 1.16325213437674 1.70772958601522 0.81731717328669 1.17218736589032 0.798457476188047 0.089864250338992 NA NA NA 0.0559986665471251 93.603589787924 a1108 BRCA2_mut 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 6 41 2.77258872223978 NA 4.35025026545958 5.10758214888602 -0.757331883426438 1.72511108596294 0.86762339544629 0.757408843882276 0.439004705023795 0.872880892102822 0.0899798975950534 NA NA NA 0.336106338692665 93.603589787924 a1109 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 150 Bicalutamide ANDR (androgen receptor) 6 42 0.0237165266173161 NA 2.36008584402984 2.82008801479883 -0.460002170768987 0.687466240393342 0.598337626131875 0.755764515763263 0.669126923971992 0.768800340608366 0.0900338643309177 NA NA NA 0.169434494307654 93.603589787924 a1110 gain_cnaBRCA10_(MDM2,NUP107) 219 AT-7519 CDK9 5 44 2.32630161961136 NA 2.97032235139657 1.52446392972649 1.44585842167008 1.20469766721253 1.81364889626579 0.816869870469749 1.2001836319776 0.797209660947619 0.0900348267724149 NA NA NA 0.051914265421431 93.603589787924 a1111 gain_cnaBRCA64_(SDHC) 1054 PD-0332991 CDK4, CDK6 7 35 1.38629436111989 0.693147180559945 3.73699021531604 2.71208764291566 1.02490257240038 0.998053403039593 1.48832798977433 0.718938948519418 1.02690153580862 0.688626821132207 0.0901900078891131 NA NA NA 0.0430088329727995 93.603589787924 a1112 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 71 Pyrimethamine Dihydrofolate reductase (DHFR) 4 10 2.99573227355399 NA 5.28015554365557 4.28531676214964 0.994838781505924 0.275485138854253 1.04197103809248 1.08984528751095 3.61122485823908 0.954766250823206 0.090284542893144 NA NA NA 0.0172233605145171 93.603589787924 a1113 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 56 WH-4-023 SRC family, ABL 3 9 1.63315443905142 NA 4.1605987395197 2.91084616453389 1.24975257498581 0.146323991147084 1.11556622607035 1.2498322256595 8.54099567124005 1.12028541719853 0.0903003636881861 NA NA NA 0.00993350389982424 93.603589787924 a1114 gain_cnaBRCA30_(CRNKL1,FOXA2) 330 XMD13-2 RIPK 5 43 2.32630161961136 NA 4.59013383562462 3.61996164068658 0.970172194938044 1.50563969921976 1.15298508635949 0.816770884108854 0.644358803398183 0.841443836885462 0.0905851962027001 NA NA NA 0.22737255024441 93.603589787924 a1115 loss_cnaBRCA60 163 JQ1 BRD4 3 44 0.940007258491471 NA -1.05878502658216 0.409646410800196 -1.46843143738236 1.32256556229568 1.42752087759678 1.03191159317877 1.1102900901438 1.02865846687612 0.0906034279156898 NA NA NA 0.187126531263236 93.603589787924 a1116 gain_cnaBRCA15 94 TGX221 PI3Kbeta 6 8 2.30258509299405 NA 3.10908668227621 4.26422974648888 -1.15514306421267 1.53898090183684 0.791230303232688 0.993433984459748 0.750589603050925 1.45993279010316 0.0907023033098486 NA NA NA 0.137031773984398 93.603589787924 a1117 TP53_mut 171 AKT inhibitor VIII AKT1, AKT2, AKT3 37 10 0.940007258491471 NA 1.72831899638824 2.48191561173078 -0.753596615342543 1.2682258867396 1.02277929078679 0.616144910736601 0.594213241680403 0.736812548055041 0.0907082853383092 NA NA NA 0.0665235818004697 93.603589787924 a1118 gain_cnaBRCA47_(EGFR) 219 AT-7519 CDK9 7 42 2.32630161961136 NA 0.602178859621355 1.85030411065712 -1.24812525103576 1.35536862176514 1.82304321438823 0.705062636993661 0.920875126510081 0.684638324086357 0.0907274375449582 NA NA NA 0.058384122308967 93.603589787924 a1119 gain_cnaBRCA64_(SDHC) 1009 ATRA Retinoic acid and retinoid X receptor agonist 9 36 2.30258509299405 NA 4.6879134906076 3.96048521683037 0.727428273777234 0.710989371203351 1.20336249183385 0.644798490603736 1.02312116501272 0.604496383021443 0.0907712003903084 NA NA NA 0.0290104291139355 93.603589787924 a1120 PTEN_mut 1194 SB-505124 TGFR1 (ALK5) 8 39 2.30258509299405 NA 3.89040253592972 4.49127530530972 -0.600872769380009 1.21094045721977 0.824895915130256 0.670662025566976 0.496203397778591 0.728422529871696 0.090854254414233 NA NA NA 0.215092417176966 93.603589787924 a1121 loss_cnaBRCA17 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 6 37 0.693147180559945 NA 3.51849880270443 2.80948678391792 0.709012018786506 0.257025143684759 0.988401302408426 0.761958055399183 2.75853174760251 0.717332137319997 0.0909173356095692 NA NA NA 0.000884368234348262 93.603589787924 a1122 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 71 Pyrimethamine Dihydrofolate reductase (DHFR) 5 9 2.99573227355399 NA 5.17099509632009 4.23542381272425 0.935571283595842 0.461773268770708 1.07006736150303 1.02418657101026 2.02604036843977 0.874310643660534 0.0912130723455889 NA NA NA 0.0430678587548371 93.603589787924 a1123 gain_cnaBRCA61_(NOTCH2) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 3 42 -0.669430653942629 NA -1.20344357655779 -3.64924491262894 2.44580133607115 2.87522038277287 2.34253653692952 1.03199723313317 0.850648301857269 1.0440824710794 0.091370954026491 NA NA NA 0.276165853496307 93.603589787924 a1124 PTEN_mut 150 Bicalutamide ANDR (androgen receptor) 8 40 0.0237165266173161 NA 2.42384886941967 2.83033551825931 -0.406486648839636 0.726487151395174 0.585207752853565 0.667657245183373 0.559523520903299 0.694602296120554 0.0914445331569305 NA NA NA 0.171037075293008 93.603589787924 a1125 CDH1_mut 257 NPK76-II-72-1 PLK3 4 45 2.32630161961136 NA 2.20059839986482 3.59259246570878 -1.39199406584397 1.50756457844225 1.55107615877894 0.899026208187743 0.923339594037359 0.897437600317314 0.091444566718731 NA NA NA 0.16039423619943 93.603589787924 a1126 loss_cnaBRCA33 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 6 42 2.32630161961136 NA 4.51115524201108 5.02239542654377 -0.511240184532688 0.36393715734817 0.708464031093593 0.75234350331791 1.40474852377768 0.721617699833726 0.0914532937985349 NA NA NA 0.0175525530397865 93.603589787924 a1127 loss_cnaBRCA28_(GPS2) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 3 42 0.693147180559945 NA 1.9733034945897 0.529302167196134 1.44400132739357 1.09691604467249 1.41279077204928 1.03166495156752 1.31641918668872 1.0220914207268 0.0914718938673467 NA NA NA 0.137854319818329 93.603589787924 a1128 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 166 FTI-277 Farnesyl transferase (FNTA) 7 40 0.0237165266173161 NA 2.72240560542551 2.16073482050178 0.56167078492373 0.920997906799515 0.774438492332459 0.706023428984044 0.609850229601007 0.725261967844711 0.0917085467211571 NA NA NA 0.168661122967044 93.603589787924 a1129 gain_cnaBRCA61_(NOTCH2) 151 QS11 ARFGAP 3 45 2.32630161961136 NA 5.15277158622168 3.66762844652452 1.48514313969716 0.308597234377823 1.47717204038448 1.026974029002 4.81256140448383 1.00539618886274 0.0917357460221584 NA NA NA 0.000234415231375369 93.603589787924 a1130 loss_cnaBRCA18 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 15 31 2.30258509299405 NA 1.76779525284414 1.24158442936966 0.526210823474483 0.83521794591177 1.02799476785938 0.542028361082424 0.630028157381175 0.51188083823639 0.0918497090487986 NA NA NA 0.0725964817438614 93.603589787924 a1131 POLR2B_mut 271 VNLG/124 HDAC, RAR 3 46 1.63315443905142 NA 3.38656893396357 4.20132300813071 -0.814754074167142 0.830543567187711 0.792952554325201 1.02537876663799 0.980988964764325 1.02749410380611 0.091868384002361 NA NA NA 0.226921939841177 93.603589787924 a1132 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1017 Olaparib PARP1, PARP2 6 39 1.6094379124341 NA 4.64223807268586 3.98669194783809 0.655546124847775 0.941939706079426 0.856863720923939 0.755947071033207 0.695953382808664 0.765052958644244 0.0919234502329056 NA NA NA 0.156831490013394 93.603589787924 a1133 gain_cnaBRCA8_(CHD4,WNK1) 292 Masitinib KIT 4 44 2.99573227355399 NA 3.13365422907502 4.0900249406918 -0.956370711616776 0.776923083079402 1.08125361307893 0.898791880543383 1.2309721933169 0.884501748755743 0.0919611679494712 NA NA NA 0.0834494983844588 93.603589787924 a1134 PIK3CA_mut 1022 AZD7762 CHEK1, CHEK2 16 29 0.693147180559945 NA 1.45202269285726 0.60280750921078 0.849215183646479 1.69075614006803 1.52078384966413 0.536746975098628 0.502269466022646 0.558406234938665 0.0919746515536303 NA NA NA 0.10581674599397 93.603589787924 a1135 gain_cnaBRCA64_(SDHC) 154 CHIR-99021 GSK3B 8 39 0.940007258491471 NA 3.76576689014334 3.17485634009993 0.59091055004341 0.835819941420153 0.893008470073018 0.668182211580885 0.706983072262413 0.661707665544419 0.092017208420911 NA NA NA 0.100471685682062 93.603589787924 a1136 gain_cnaBRCA58_(CCND1) 135 Gemcitabine DNA replication 9 38 0.0237165266173161 NA 1.11593092876544 -0.604707727800518 1.72063865656595 1.28147350146608 2.91455904492726 0.637867281849953 1.34270326666719 0.590359855485066 0.0921832678302073 NA NA NA 0.0112897436953648 93.603589787924 a1137 CDH1_mut 310 YM201636 FYV1 4 45 1.63315443905142 NA 1.59641615878624 2.48740093491172 -0.890984776125489 0.824055665134863 1.00434586046235 0.896529214347164 1.08121916251819 0.887129435387251 0.0923212099848234 NA NA NA 0.114824523923102 93.603589787924 a1138 loss_cnaBRCA57 253 XMD14-99 EPHB3, CAMK1 5 43 2.32630161961136 NA 5.48240419236955 4.8692294736943 0.613174718675243 0.20356217637536 0.7877395981695 0.812043335368272 3.01222324104344 0.778397734606842 0.0924094825744614 NA NA NA 0.000464317622179686 93.603589787924 a1139 gain_cnaBRCA15 276 CAY10603 HDAC6 22 27 2.99573227355399 NA 0.912156554270327 1.39014827149277 -0.477991717222438 1.05734602335818 0.891698100848856 0.493173504417597 0.452067446855585 0.536046579854115 0.0925452719271376 NA NA NA 0.0991306458681415 93.603589787924 a1140 PTEN_mut 1143 HG-5-88-01 EGFR, ADCK4 4 22 2.30258509299405 NA 3.78100552829276 4.6709991417222 -0.889993613429439 0.695214463416568 0.963978279084308 0.952252816170585 1.28017131441087 0.923250692199053 0.0925629310942704 NA NA NA 0.0749794304432103 93.603589787924 a1141 gain_cnaBRCA13_(FGFR1,WHSC1L1) 59 WZ-1-84 BMX 3 9 2.32630161961136 NA 4.56181324879944 3.22859162474917 1.33322162405027 0.256707562439588 1.1958617856044 1.23933613950245 5.19354245500274 1.11486263722061 0.0926663238218037 NA NA NA 0.011087229296252 93.603589787924 a1142 gain_cnaBRCA63 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 5 38 0.693147180559945 NA 3.58215645495081 2.81976898806409 0.762387466886719 1.0966445884913 0.911141364812082 0.819007056834927 0.695200135839424 0.83673894779649 0.0926816591962446 NA NA NA 0.199741915710301 93.603589787924 a1143 gain_cnaBRCA31 135 Gemcitabine DNA replication 16 31 0.0237165266173161 NA 0.66541275754554 -0.760713529621271 1.42612628716681 3.01234761553164 2.52590342721516 0.52862274932945 0.473426864752831 0.564600479892113 0.0928063968644058 NA NA NA 0.116779356732979 93.603589787924 a1144 gain_cnaBRCA9_(KRAS) 268 YM155 BIRC5 (Survivin) 4 45 1.63315443905142 NA -4.87920748810939 -3.48147760320947 -1.39772988489992 0.679999508608164 1.60458600713563 0.894828926899463 2.0554866102195 0.871084428434617 0.0929221239005793 NA NA NA 0.013170334084987 93.603589787924 a1145 BRCA2_mut 1175 AG-014699 PARP1, PARP2 5 38 1.6094379124341 NA 3.13858762011186 3.95669999440049 -0.81811237428863 1.49743836864312 0.930119226224368 0.818324044749646 0.546341266138351 0.879577962934486 0.0929448803811787 NA NA NA 0.293441521485968 93.603589787924 a1146 gain_cnaBRCA64_(SDHC) 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 6 20 2.30258509299405 NA 5.28013092971015 4.50749002339176 0.772640906318388 0.864613227607817 0.969612863264889 0.814423466448517 0.893626053415936 0.796855049670798 0.0929545375652757 NA NA NA 0.0945150328875584 93.603589787924 a1147 gain_cnaBRCA62 221 TAK-715 p38a 10 39 2.99573227355399 2.32630161961136 4.00621672543517 4.60418758273163 -0.597970857296462 1.29817377154593 0.893287475352117 0.607815248655741 0.460624663972657 0.66940472557365 0.0929749748906452 NA NA NA 0.195674850204098 93.603589787924 a1148 gain_cnaBRCA15 211 TL-2-105 CRAF 22 27 2.32630161961136 1.63315443905142 3.6189318794615 4.14272710153005 -0.523795222068554 1.19214752454278 0.947181774244385 0.492459975312445 0.439371144330014 0.553003907287397 0.0930039974607675 NA NA NA 0.101864718265173 93.603589787924 a1149 TP53_mut 1058 GDC0941 PI3K (class 1) 34 9 1.38629436111989 0.693147180559945 1.16389315911918 2.033971453378 -0.870078294258822 1.36974834689139 1.26821629383756 0.644246300726138 0.635210326213162 0.686064592046842 0.0932282614743041 NA NA NA 0.0945670578013551 93.603589787924 a1150 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1028 VX-702 p38 6 39 0.693147180559945 NA 3.86184215939822 3.35990670448278 0.501935454915439 0.813279466599868 0.645129320994257 0.75268076603269 0.617174631266561 0.778038508840163 0.0932901780313443 NA NA NA 0.198926247731879 93.603589787924 a1151 PTEN_mut 1042 BIRB 0796 p38, JNK2 6 37 2.30258509299405 NA 3.78124630738734 4.46151705415808 -0.680270746770737 1.03543409703995 0.87938280689272 0.755971039306242 0.656990868579141 0.773577492576252 0.0933965603258675 NA NA NA 0.176886526337942 93.603589787924 a1152 loss_cnaBRCA17 133 Doxorubicin DNA intercalating 11 37 0.0237165266173161 NA -1.84368390471841 -0.78893070966829 -1.05475319505012 1.36055312687966 1.89538735940583 0.588345730733011 0.775238521901112 0.556484240446117 0.0934080457388132 NA NA NA 0.0523216509087299 93.603589787924 a1153 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1052 RO-3306 CDK1 16 27 1.6094379124341 NA 3.92377273979083 3.28976261745933 0.634010122331492 0.992497732864997 1.26122538328318 0.541846504617988 0.638802590008265 0.502693753816672 0.0934428496990216 NA NA NA 0.0757134089270454 93.603589787924 a1154 loss_cnaBRCA17 190 Bleomycin DNA damage 11 37 4.15888308335967 NA 0.863029470061141 2.43972527927404 -1.5766958092129 2.56805418533449 2.71050759026509 0.588279027346278 0.613965164059627 0.581697618141957 0.0934440793635597 NA NA NA 0.0953325208511057 93.603589787924 a1155 loss_cnaBRCA23 221 TAK-715 p38a 3 46 2.99573227355399 2.32630161961136 3.53989151323234 4.54360453133018 -1.00371301809784 0.614506606701454 0.997143855197564 1.02013982914186 1.63336407965663 1.0065879791226 0.0934903921635015 NA NA NA 0.087162192118702 93.603589787924 a1156 loss_cnaBRCA18 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 15 31 1.63315443905142 NA 1.37202981012654 2.20977166593353 -0.837741855806994 1.30618777631081 1.65667586175743 0.539171879706542 0.641364029736297 0.505676381931648 0.093519468935358 NA NA NA 0.0710365339120997 93.603589787924 a1157 loss_cnaBRCA24 1149 TW 37 BCL2, BCL2L1 3 40 1.6094379124341 NA 1.01900878625819 -0.229488719450377 1.24849750570856 2.63545839510672 1.09318794587537 1.02779590378815 0.473730683066999 1.14207031866677 0.0935308346011124 NA NA NA 0.498677762155858 93.603589787924 a1158 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 38 AZD-0530 SRC, ABL1 3 11 0.693147180559945 NA 2.03088044396584 2.73800894979202 -0.70712850582618 0.823980103167764 0.539253200931806 1.18600732295067 0.85818638472901 1.31131072491418 0.0936374848164923 NA NA NA 0.271489440940394 93.6139510087884 a1159 gain_cnaBRCA27_(CLTC,PPM1D) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 10 35 2.30258509299405 NA 3.78402800390361 3.00339239945141 0.780635604452201 0.898343490590449 1.35160564925907 0.614580775007728 0.868972294705577 0.577561661480278 0.0937327237572675 NA NA NA 0.0435882027495808 93.6139510087884 a1160 gain_cnaBRCA63 177 GSK-650394 SGK3 6 41 2.77258872223978 NA 5.09544500658424 3.85624278264565 1.23920222393858 1.58213222964234 1.6650038822187 0.748310191002452 0.783248201838804 0.744263864590681 0.0937837319027503 NA NA NA 0.120048421185029 93.6139510087884 a1161 loss_cnaBRCA17 291 KIN001-266 MAP3K8 (COT) 11 38 2.99573227355399 NA 3.25511404349604 3.93017977791238 -0.675065734416344 1.01118155946346 1.1888532018197 0.585311083773204 0.667600915086445 0.567829344601219 0.0939483533287073 NA NA NA 0.0769668888820695 93.6975007056935 a1162 loss_cnaBRCA33 346 THZ-2-102-1 CDK7 5 43 0.916290731874155 2.99573227355399 -3.13389232597134 -1.12600244248199 -2.00788988348935 1.63648305424762 2.55235275101236 0.807632816745642 1.22695427751465 0.7866819673311 0.0941388059015255 NA NA NA 0.0483950265624432 93.6987162188381 a1163 gain_cnaBRCA12_(TERT) 269 NSC-207895 MDM4 9 40 2.99573227355399 NA 4.00645809813672 4.7383763673006 -0.731918269163879 1.47048046047935 1.08699513574192 0.630286293695548 0.497740900906147 0.673340887274819 0.0941583655014419 NA NA NA 0.188964598753783 93.6987162188381 a1164 NF1_mut 305 TPCA-1 IKK 5 44 2.99573227355399 NA 5.15515606019024 4.06732299127995 1.08783306891029 0.978102871872203 1.37950794305255 0.805802019249859 1.11218676500566 0.788566006008744 0.094341865742832 NA NA NA 0.0659175622365461 93.6987162188381 a1165 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 222 BX-912 PDPK1 (PDK1) 6 43 2.32630161961136 NA 2.91914351254576 4.01838132879875 -1.09923781625298 1.02211315735675 1.52306753683664 0.743799637128106 1.07545608658017 0.721726246320015 0.0944698998012972 NA NA NA 0.0485552779842255 93.6987162188381 a1166 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 6 37 0.693147180559945 NA 2.73737663563786 1.51079627343459 1.22658036220327 0.679303133796212 1.719038326596 0.753341575089171 1.80564508123002 0.713527059418223 0.0945030637806242 NA NA NA 0.00618761012002796 93.6987162188381 a1167 loss_cnaBRCA17 203 BMS-345541 IKBKB 11 38 2.77258872223978 NA 3.08575416726533 3.66160471806617 -0.575850550800835 0.65863635407543 1.05675842366584 0.584256324233139 0.874307267185688 0.544921656553483 0.0945246035335023 NA NA NA 0.0371170246012774 93.6987162188381 a1168 gain_cnaBRCA64_(SDHC) 253 XMD14-99 EPHB3, CAMK1 8 40 2.32630161961136 NA 4.51704650262918 5.01631290774173 -0.499266405112548 1.3479535098449 0.589037151544738 0.66091051895039 0.370388445496163 0.847597479723023 0.0946653341679002 NA NA NA 0.335708814446759 93.6987162188381 a1169 gain_cnaBRCA30_(CRNKL1,FOXA2) 1007 Docetaxel Microtubules 5 40 -4.38202663467388 NA -3.5025297978875 -4.72287338773211 1.22034358984461 2.33152212479836 1.39355160474767 0.810504419248781 0.523410683889673 0.875707498514615 0.0947175862721061 NA NA NA 0.311055621536342 93.6987162188381 a1170 gain_cnaBRCA47_(EGFR) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 6 37 1.6094379124341 NA 1.99578866387566 3.09997977583748 -1.10419111196183 1.08901049327236 1.51174115172248 0.752826972105122 1.01393982774569 0.730410170222401 0.0947208833493922 NA NA NA 0.0600621375411776 93.6987162188381 a1171 MLL3_mut 310 YM201636 FYV1 3 46 1.63315443905142 NA 1.46680343177417 2.4764847045837 -1.00968127280952 0.664758268822552 1.0064430102499 1.01547142580136 1.51886982105226 1.00321753196817 0.0949556709457533 NA NA NA 0.102988139289286 93.6987162188381 a1172 loss_cnaBRCA17 1241 CHIR-99021 GSK3B 9 37 2.30258509299405 NA 4.71826735014519 4.11308108386737 0.605186266277824 0.705867964646681 1.00122918649596 0.634134032588649 0.857364686582352 0.604443292744807 0.0950251400858064 NA NA NA 0.0503575512077023 93.6987162188381 a1173 TP53_mut 1527 GDC0941 (rescreen) PI3K 36 9 1.38629436111989 NA 0.837245172713437 1.55429851596432 -0.717053343250887 0.979964498282252 1.62394289309827 0.635705475482508 0.731713592183989 0.441550836730991 0.0952641788276467 NA NA NA 0.234913685492792 93.6987162188381 a1174 gain_cnaBRCA31 134 Etoposide TOP2 16 31 2.77258872223978 NA 3.20652354577451 2.10062590395846 1.10589764181605 2.08603777342792 2.12019260199352 0.524403164644523 0.530142673302968 0.521602443464913 0.0953611424090285 NA NA NA 0.096813390062958 93.6987162188381 a1175 gain_cnaBRCA9_(KRAS) 309 Y-39983 ROCK 4 45 2.99573227355399 NA 5.79866070264969 4.85820939166123 0.940451310988467 0.151869028522486 1.09406520416136 0.8878316151235 6.19251548612639 0.85959347524388 0.0954293062777258 NA NA NA 6.27013357811925e-06 93.6987162188381 a1176 loss_cnaBRCA18 291 KIN001-266 MAP3K8 (COT) 16 33 2.99573227355399 NA 3.37605412033124 3.97382485193415 -0.597770731602916 1.02288795115596 1.21014271506846 0.518139248487713 0.584395124536738 0.493967136404319 0.095580007426472 NA NA NA 0.0798665592670092 93.6987162188381 a1177 loss_cnaBRCA60 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 3 45 2.07944154167984 NA 4.29353640355593 3.14235458730029 1.15118181625564 1.1208487963846 1.1353478657702 1.01450619820377 1.02706254400136 1.01394634275786 0.0956230231442168 NA NA NA 0.211661180600711 93.6987162188381 a1178 gain_cnaBRCA19 226 GSK1070916 AURKB 4 45 0.940007258491471 2.32630161961136 0.852557126291926 2.54184909435746 -1.68929196806553 2.46034429520772 1.86071522282033 0.886935940671641 0.686607956193753 0.907872385493268 0.0957542324136226 NA NA NA 0.264885544271512 93.6987162188381 a1179 gain_cnaBRCA62 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 10 39 3.68887945411394 NA 2.89919437144376 3.60311611566173 -0.703921744217974 0.745878234553767 1.24804659822558 0.602306237381578 0.943748874290595 0.564018799633587 0.0958869661514552 NA NA NA 0.0321251382376084 93.6987162188381 a1180 loss_cnaBRCA18 190 Bleomycin DNA damage 16 32 4.15888308335967 NA 1.14794163706603 2.54362791596111 -1.39568627889508 2.5672364517028 2.73493557634122 0.520505830640233 0.543653187056202 0.510317789921116 0.0958906910826131 NA NA NA 0.0920512821704304 93.6987162188381 a1181 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1529 MLN4924 NEDD8-activating enzyme 7 30 0 NA 1.32928819080988 0.145198258042362 1.18408993276751 1.89203761083818 1.59376997117256 0.718179477452329 0.625827904257653 0.742949079343213 0.0959378100599195 NA NA NA 0.163163933838471 93.6987162188381 a1182 PTEN_mut 1005 Cisplatin DNA crosslinker 7 38 1.79175946922805 2.30258509299405 2.9878302689489 3.79576178786143 -0.807931518912536 1.17166003665377 1.15110283795346 0.700118051665705 0.689561386099644 0.701876055095959 0.0959415900184639 NA NA NA 0.12997412510462 93.6987162188381 a1183 loss_cnaBRCA57 303 PIK-93 PI4K, PI3K 5 44 2.99573227355399 NA 3.79216855462102 2.67781795478652 1.1143505998345 0.912022192144359 1.42684107240027 0.801421587902536 1.22184592593567 0.780991395180341 0.0960929561389003 NA NA NA 0.0490429450022445 93.6987162188381 a1184 gain_cnaBRCA13_(FGFR1,WHSC1L1) 202 GSK-1904529A IGF1R 10 38 0.0237165266173161 NA 2.57877964478624 2.08727831440696 0.491501330379276 0.859751868590103 0.802509935762892 0.603790527675338 0.57167811822879 0.612455134168574 0.096100413960956 NA NA NA 0.126213370703763 93.6987162188381 a1185 loss_cnaBRCA29_(MAP2K4) 170 Shikonin unknown 7 40 2.77258872223978 NA 0.690553050290142 -0.116607375445714 0.807160425735856 1.96774334096538 0.977182298645739 0.696284567184037 0.4101959889443 0.82600803028717 0.0961319406956621 NA NA NA 0.325692574276636 93.6987162188381 a1186 gain_cnaBRCA30_(CRNKL1,FOXA2) 1059 AZD8055 MTORC1/2 4 39 0.693147180559945 NA 0.926800548533485 0.0487517782765384 0.878048770256947 0.889371691841707 0.989105937605649 0.89400516827124 0.987268628303974 0.887719643441287 0.0961731039818319 NA NA NA 0.14005180210821 93.6987162188381 a1187 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 3 Rapamycin MTOR 5 9 -2.30258509299405 NA -1.17577698102826 -3.61248944200875 2.43671246098048 0.914365474095637 2.89293827917562 1.0067613543217 2.66492177363821 0.842296732882548 0.0962152696940522 NA NA NA 0.0412519741314231 93.6987162188381 a1188 loss_cnaBRCA20 1053 MK-2206 AKT1, AKT2 3 39 1.38629436111989 0.693147180559945 2.91218098105072 1.27708659682902 1.63509438422171 1.3556487362826 1.61395149210733 1.02064173830526 1.20613425916317 1.01310007904065 0.0962336473978031 NA NA NA 0.161429829364594 93.6987162188381 a1189 loss_cnaBRCA57 283 GSK2126458 PI3K, MTOR 5 43 -2.05572501506252 0.0237165266173161 -1.90789164947783 -3.18878421267327 1.28089256319544 2.04960814347356 1.5472225910031 0.801964431799931 0.624945098541939 0.827865732211818 0.0964005915127258 NA NA NA 0.239353702940161 93.6987162188381 a1190 gain_cnaBRCA63 292 Masitinib KIT 7 41 2.99573227355399 NA 3.37912639515529 4.11809340343054 -0.738967008275252 1.1440816918877 1.05258770726289 0.693886863426627 0.645904058700547 0.702047917884994 0.0965083080215044 NA NA NA 0.149643649182924 93.6987162188381 a1191 loss_cnaBRCA57 238 CAL-101 PI3Kdelta 5 44 2.99573227355399 2.32630161961136 5.38346091292943 4.64345323153459 0.74000768139484 0.601488794875433 0.949101153056422 0.800337955388224 1.23029337819684 0.779693164434338 0.0965302595455649 NA NA NA 0.047938465598405 93.6987162188381 a1192 PTEN_mut 163 JQ1 BRD4 8 39 0.940007258491471 NA -0.462866719281012 0.475667198710519 -0.938533917991531 1.09550144231872 1.47730395972337 0.658782653209995 0.856716277803381 0.635301836033305 0.096538033007122 NA NA NA 0.0593658477482839 93.6987162188381 a1193 loss_cnaBRCA57 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 5 42 2.77258872223978 NA 5.72923126828456 4.92538603227765 0.803845236006912 0.211897355190501 1.04678505605314 0.802902654748268 3.79355955285159 0.767918142658412 0.0965729441849578 NA NA NA 0.00014254110948496 93.6987162188381 a1194 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1042 BIRB 0796 p38, JNK2 5 38 2.30258509299405 NA 5.01025283906011 4.28190380665454 0.72834903240557 0.583128061794237 0.928307292353865 0.808849773593087 1.24903787028273 0.784599063698757 0.0966606906076594 NA NA NA 0.0460480954839204 93.6987162188381 a1195 gain_cnaBRCA27_(CLTC,PPM1D) 346 THZ-2-102-1 CDK7 9 39 0.916290731874155 2.99573227355399 -0.0678792238960286 -1.62760650362867 1.55972727973264 2.52045052234641 2.48028521118517 0.62707215584104 0.618828763311971 0.628849969632059 0.0967008946208753 NA NA NA 0.119421613306142 93.6987162188381 a1196 gain_cnaBRCA19 279 BIX02189 MAP2K5 (MEK5) 4 45 2.99573227355399 NA 4.31286902746935 5.09086600161865 -0.777996974149303 0.41516792982758 0.903241922485469 0.883874814151875 1.87393321654784 0.861338424160466 0.0968716324862677 NA NA NA 0.0200327537711962 93.7856716186032 a1197 gain_cnaBRCA9_(KRAS) 300 CX-5461 RNA Pol I 4 45 2.32630161961136 NA 2.55717995518432 4.03282621216056 -1.47564625697624 1.61462807068792 1.67423800002145 0.883357798490459 0.913923326223068 0.88138380383036 0.097061416553429 NA NA NA 0.16362756655072 93.7915623005284 a1198 BRCA1_mut 276 CAY10603 HDAC6 4 45 2.99573227355399 NA 1.962208755673 1.10561361114578 0.856595144527224 0.911686528487043 0.973881657009285 0.883059640681287 0.939572010511942 0.879568003321637 0.0971710025729322 NA NA NA 0.15497586784136 93.7915623005284 a1199 BRCA1_mut 269 NSC-207895 MDM4 4 45 2.99573227355399 NA 5.54536724854018 4.52026019069097 1.02510705784921 0.799259654124416 1.18262395972971 0.882238151348791 1.28257075477206 0.866807280044874 0.0974734640396836 NA NA NA 0.0746581009779334 93.7915623005284 a1200 gain_cnaBRCA48 224 AS605240 PI3Kgamma 5 44 2.99573227355399 2.32630161961136 4.37795177576283 3.14438231450125 1.23356946126158 1.36126067884854 1.56218810883845 0.797856294621633 0.906196351976485 0.789642075933348 0.0975379340300402 NA NA NA 0.11434842633121 93.7915623005284 a1201 gain_cnaBRCA63 194 AUY922 HSP90 6 41 -1.36257783450257 NA -1.30463898206238 -2.55312874692273 1.24848976486035 2.72575563101875 1.50901805987574 0.739587245826023 0.458034370598998 0.827352434047846 0.0975547116585479 NA NA NA 0.318429579479006 93.7915623005284 a1202 gain_cnaBRCA62 1030 KU-55933 ATM 7 35 2.30258509299405 NA 4.7482747060231 4.11710428485284 0.63117042117026 0.919004527231154 0.89491565965954 0.702416405611285 0.686797945459417 0.70528481020254 0.0975620472902258 NA NA NA 0.132316772292934 93.7915623005284 a1203 loss_cnaBRCA33 1 Erlotinib EGFR 3 9 0.693147180559945 NA 2.45975991856346 3.08217681989653 -0.622416901333064 0.987036075706506 0.287622644109359 1.21825051959595 0.630591846288443 2.16400521336009 0.0975936180400359 NA NA NA 0.38886714654585 93.7915623005284 a1204 PTEN_mut 1133 JNJ-26854165 MDM2 7 36 2.30258509299405 NA 2.47025860493903 3.06575745394097 -0.595498849001936 0.444466247395618 0.901897995850007 0.700202861274946 1.33980668384001 0.660272948539706 0.0976436584114618 NA NA NA 0.0168322027457402 93.7915623005284 a1205 gain_cnaBRCA47_(EGFR) 1047 Nutlin-3a MDM2 6 37 2.07944154167984 1.38629436111989 4.83577249830769 4.10497247126142 0.730800027046273 0.374185838428112 1.03647058498424 0.745738545268274 1.95304031311349 0.705085158839687 0.0977639174890323 NA NA NA 0.00442070570649252 93.7915623005284 a1206 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 200 LAQ824 HDAC 6 42 0.0237165266173161 NA -3.57449243692753 -2.55732097745034 -1.01717145947719 0.817221919506302 1.43285044955705 0.737449847787111 1.24466982003087 0.709893666705862 0.0978509734577604 NA NA NA 0.029048967746338 93.7915623005284 a1207 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 226 GSK1070916 AURKB 7 42 0.940007258491471 2.32630161961136 3.52971147135194 2.2163204155188 1.31339105583314 0.994661271710931 2.00424121199576 0.689306272541831 1.32044052903955 0.655305882332049 0.0979505215571686 NA NA NA 0.0159613557342097 93.7915623005284 a1208 loss_cnaBRCA29_(MAP2K4) 152 CP466722 ATM 7 42 2.77258872223978 NA 2.11695704011598 2.83233921410411 -0.715382173988129 0.654139616487132 1.08305837795562 0.689048918947851 1.09362306754922 0.660520419350322 0.0980723261539403 NA NA NA 0.0331481837104584 93.7915623005284 a1209 gain_cnaBRCA12_(TERT) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 9 34 1.6094379124341 NA 2.20946236101302 3.14084771882716 -0.931385357814144 0.707420145481393 1.59849010750492 0.634572921009843 1.31659433755642 0.582665700238797 0.0980784820172945 NA NA NA 0.0150534665370182 93.7915623005284 a1210 gain_cnaBRCA14_(RAD21) 1243 piperlongumine Increases ROS levels 21 26 2.30258509299405 NA 1.93893551739602 1.52553735579123 0.413398161604789 1.00234296629344 0.669815344209323 0.495601109592755 0.412431847687319 0.61718228042802 0.0981005203408899 NA NA NA 0.114543294061633 93.7915623005284 a1211 TP53_mut 32 VX-680 AURKA, AURKB, AURKC, FLT3, ABL1, JAK2 9 3 0.693147180559945 NA 1.77962893919554 -0.57432185078751 2.35395078998305 2.1318617807128 0.753196849831057 1.21568375811207 1.10417608274585 3.12527965366696 0.0982096528477928 NA NA NA 0.0185384280199955 93.7915623005284 a1212 gain_cnaBRCA14_(RAD21) 54 CGP-082996 CDK4 6 6 1.63315443905142 NA 2.32701097767766 3.29116452691857 -0.964153549240913 1.0889514273707 0.701963584404444 1.05242636997544 0.885396285827813 1.37350935384905 0.0983171709524952 NA NA NA 0.103415483850545 93.7915623005284 a1213 gain_cnaBRCA31 38 AZD-0530 SRC, ABL1 4 10 0.693147180559945 NA 2.1334252522097 2.76770387707709 -0.634278624867393 0.703342418552529 0.558862275763174 1.06020135113392 0.901806301079823 1.13494621550762 0.098351667029622 NA NA NA 0.172900067717866 93.7915623005284 a1214 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 228 KIN001-102 AKT1 7 42 2.32630161961136 NA 1.13174048332697 2.0790307814223 -0.94729029809533 1.30502788243851 1.38629141224302 0.688345388842936 0.725877439741186 0.68332696122139 0.0984059420474959 NA NA NA 0.114203735698449 93.7915623005284 a1215 gain_cnaBRCA47_(EGFR) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 40 1.38629436111989 NA 1.92865088872806 2.99810299725516 -1.06945210852709 1.22966465823889 1.4724640865907 0.739119826301409 0.86971037295546 0.726300979607099 0.0984362979771656 NA NA NA 0.09263825074607 93.7915623005284 a1216 BRCA2_mut 306 TG101348 JAK2 6 42 2.32630161961136 NA 2.41688845910046 3.34031757059379 -0.923429111493329 0.855681163130843 1.29495205142905 0.735989391514213 1.07917428977238 0.713099076119669 0.0984977457098562 NA NA NA 0.0483959946519881 93.7915623005284 a1217 gain_cnaBRCA62 190 Bleomycin DNA damage 9 39 4.15888308335967 NA 3.43655535662468 1.76497849472282 1.67157686190186 2.11280320276735 2.78799476692128 0.623070672587544 0.791165433539872 0.599562410135994 0.0987846490422447 NA NA NA 0.0631436646642341 93.9874651816065 a1218 gain_cnaBRCA62 1004 Vinblastine Microtubules 8 37 -2.30258509299405 NA -2.77821173427366 -3.6020141116236 0.823802377349948 1.40335785567673 1.22155990296525 0.657488261568167 0.587022315097736 0.67438557482955 0.0989871657668998 NA NA NA 0.15663418297686 94.0286710810016 a1219 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 231 FMK RSK 6 43 2.99573227355399 2.32630161961136 5.21552768630337 5.64137416402761 -0.42584647772424 0.6154743614085 0.576279250258278 0.733491234681711 0.691899621536955 0.738958547498253 0.0989903705395465 NA NA NA 0.158511656567869 94.0286710810016 a1220 loss_cnaBRCA36_(FAT1,IRF2) 9 MG-132 Proteasome 3 11 0 NA 1.65878605527485 -0.0334999970690516 1.6922860523439 0.767202363254702 1.55523588212287 1.1639888005653 2.20578837265922 1.08812179026757 0.0991907340631287 NA NA NA 0.0334359008652486 94.1252685164518 a1221 CDH1_mut 341 EX-527 SIRT1 4 45 2.99573227355399 NA 5.12568448915921 5.68762601653735 -0.56194152737814 0.249861295986333 0.658680672304807 0.877442634780247 2.24901389853064 0.853131951499102 0.0992546444931235 NA NA NA 0.00822944769686539 94.1252685164518 a1222 MLL3_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 3 40 2.30258509299405 NA 2.76050153091863 3.88760182777855 -1.12710029685992 1.30844487630051 1.10584911955679 1.00941737079835 0.8614044942013 1.01921706761556 0.0993401957175555 NA NA NA 0.27147059625192 94.1293065641223 a1223 gain_cnaBRCA15 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 21 25 1.38629436111989 NA 3.25039811082991 2.52950659580586 0.720891515024054 1.18404268275889 1.63446214662113 0.498125025496262 0.608839128454669 0.441057332844526 0.0994928786511298 NA NA NA 0.0907600455588744 94.1898830820459 a1224 gain_cnaBRCA10_(MDM2,NUP107) 176 IPA-3 PAK1, PAK2, PAK3 4 43 3.46573590279973 NA 5.68349407748756 4.38645297302841 1.29704110445915 1.36947372780208 1.4827704207589 0.879059074832552 0.94710915450771 0.874741690487261 0.0995668165579274 NA NA NA 0.152521979568512 94.1898830820459 a1225 PIK3CA_mut 34 Imatinib ABL, KIT, PDGFR 4 10 0.693147180559945 NA 3.10407828499565 2.64673034366987 0.457347941325788 0.362410116659915 0.454778581572682 1.05492640919456 1.26196240199046 1.00564969384491 0.0998534629079656 NA NA NA 0.0883517325058156 94.2770400172774 a1226 gain_cnaBRCA19 228 KIN001-102 AKT1 4 45 2.32630161961136 NA 0.836572115992998 2.04211528309008 -1.20554316709708 1.42296431860632 1.37331249873226 0.875780802357746 0.847205478966483 0.87783601198558 0.0998781131206198 NA NA NA 0.18848264354348 94.2770400172774 a1227 gain_cnaBRCA12_(TERT) 279 BIX02189 MAP2K5 (MEK5) 9 40 2.99573227355399 NA 4.58218367263868 5.12751982822422 -0.545336155585533 1.17652657616203 0.806689265926791 0.619223366969096 0.463513673753537 0.676017617463902 0.0999032110728037 NA NA NA 0.216198736504593 94.2770400172774 a1228 loss_cnaBRCA38 276 CAY10603 HDAC6 4 45 2.99573227355399 NA 0.395317662650354 1.24489281941445 -0.849575156764101 0.784011894929421 0.981940245954419 0.875387430567604 1.08362534071066 0.865200464350391 0.100026165060944 NA NA NA 0.114158834197685 94.3104603987027 a1229 loss_cnaBRCA24 1527 GDC0941 (rescreen) PI3K 3 42 1.38629436111989 NA 2.03874943441434 0.905077727574277 1.13367170684006 0.825942424104138 1.14175865931288 1.00411112255378 1.37257958152435 0.992917108701687 0.100170527643518 NA NA NA 0.126363327333434 94.3104603987027 a1230 loss_cnaBRCA18 206 Ruxolitinib JAK1, JAK2, TYK2 16 33 1.65632149833295 0.0237165266173161 4.15030448344198 4.47690577058008 -0.3266012871381 0.747119526951459 0.582129825277007 0.510770823674836 0.437147304221537 0.561045445460017 0.100249098318413 NA NA NA 0.137303911294643 94.3104603987027 a1231 loss_cnaBRCA7_(FAS,PTEN) 1053 MK-2206 AKT1, AKT2 4 38 1.38629436111989 0.693147180559945 2.6764888257352 1.25886749780377 1.41762132793143 1.81300190693762 1.58517812245949 0.884141063210159 0.781919380507421 0.894297812874123 0.100366556551752 NA NA NA 0.216722505747131 94.3104603987027 a1232 gain_cnaBRCA31 184 BMS-754807 IGF1R 16 32 0.940007258491471 NA 2.18882075432124 1.3458930548592 0.842927699462044 1.93898291009871 1.47685291948136 0.513384879195712 0.434726729705489 0.570759408972196 0.100383741139498 NA NA NA 0.138856269406262 94.3104603987027 a1233 gain_cnaBRCA31 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 16 32 2.32630161961136 NA 5.19141661587573 4.84202729727791 0.349389318597822 0.767285571100438 0.634497008013929 0.513317104561508 0.455357603162965 0.550655581011269 0.100427323319458 NA NA NA 0.128164168488598 94.3104603987027 a1234 gain_cnaBRCA48 326 GSK690693 AKT 5 43 2.32630161961136 NA 4.27843731099158 2.78389696440679 1.49454034658479 1.30507976857732 1.93399700659084 0.79174855769264 1.14517164587878 0.77277283340748 0.100590228216492 NA NA NA 0.0605043943436022 94.3537903421723 a1235 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1375 Temozolomide DNA akylating agent 14 32 3.40119738166216 NA 6.15510414757236 5.78857296759837 0.366531179973991 0.574789564415362 0.722409379542913 0.537335221073187 0.637678904882003 0.507373229575044 0.100655070522699 NA NA NA 0.0761592299604096 94.3537903421723 a1236 ARID1A_mut 171 AKT inhibitor VIII AKT1, AKT2, AKT3 5 42 0.940007258491471 NA 1.0205502798407 1.99200494248736 -0.971454662646659 1.57798084401062 1.1853888488096 0.792771936311208 0.615631467475608 0.819524043626883 0.100723162618065 NA NA NA 0.245458249028164 94.3537903421723 a1237 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 255 CP724714 ERBB2 6 42 2.32630161961136 NA 4.8468404179389 3.65392072340254 1.19291969453636 0.395269589460794 1.7233684391035 0.730855377134168 3.01799006638401 0.692202356425256 0.10079941156686 NA NA NA 0.000481409143806179 94.3537903421723 a1238 gain_cnaBRCA58_(CCND1) 1219 PFI-1 BRD2, BRD3, BRD4 9 38 2.30258509299405 NA 3.66213368136222 3.0565107053231 0.605622976039121 1.10982125714982 0.944235479032927 0.620687753584187 0.545694157628994 0.641389769275977 0.101006165205547 NA NA NA 0.158810550850805 94.470952093298 a1239 gain_cnaBRCA30_(CRNKL1,FOXA2) 164 JQ12 HDAC 5 42 1.63315443905142 NA 2.71294516198756 1.44275674384569 1.27018841814187 1.46502597629443 1.61802362057749 0.791387493825505 0.867007437884909 0.785024644874175 0.101301570240198 NA NA NA 0.127172325441232 94.5239548489631 a1240 loss_cnaBRCA24 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 43 1.38629436111989 NA 4.21074792481891 2.76427398716553 1.44647393765338 0.145077341359252 1.48144014079314 0.999146229775182 9.97036424917322 0.976397154244087 0.101386410889 NA NA NA 5.17035075569598e-07 94.5239548489631 a1241 PIK3CA_mut 309 Y-39983 ROCK 17 32 2.99573227355399 NA 5.28217499061301 4.75053408109165 0.531640909521355 0.984676297739886 1.09741554168119 0.501366984726054 0.539914396986728 0.484448132297186 0.10145958130784 NA NA NA 0.0925822951167415 94.5239548489631 a1242 gain_cnaBRCA48 221 TAK-715 p38a 5 44 2.99573227355399 2.32630161961136 5.17964770095902 4.40289191991114 0.776755781047878 0.755725147830418 1.00397387143597 0.788356903913464 1.02782841523514 0.773681271143933 0.101475614900994 NA NA NA 0.0828178307938405 94.5239548489631 a1243 loss_cnaBRCA29_(MAP2K4) 225 Genentech Cpd 10 AURKA, AURKB 7 42 2.32630161961136 NA 2.09493428819145 3.17191830667024 -1.07698401847879 1.03207588467576 1.64442919215883 0.681837931461733 1.04351243398845 0.654928788429562 0.101536340919691 NA NA NA 0.0394339174734905 94.5239548489631 a1244 gain_cnaBRCA15 1031 Elesclomol HSP70 21 23 -1.6094379124341 NA -2.51725106938465 -3.39787854991456 0.880627480529909 1.99672541496017 1.47469403026143 0.505268162613739 0.441035844954914 0.597159453051962 0.101552638252103 NA NA NA 0.107230259617414 94.5239548489631 a1245 loss_cnaBRCA36_(FAT1,IRF2) 1001 AICAR AAPK1 (AMPK) agonist 8 37 7.60090245954208 NA 7.015281838321 7.8948511783762 -0.879569340055202 1.37290727200293 1.34404109600655 0.652121038123617 0.640661869881425 0.654421462757801 0.101686347993311 NA NA NA 0.129762647754702 94.5596154475865 a1246 MLL3_mut 286 KIN001-236 TIE2 3 46 2.32630161961136 NA 3.83923026372679 4.58581314707309 -0.746582883346298 0.5957451567753 0.756954856835967 0.994382718849763 1.25319169590478 0.986297764792707 0.101813245349341 NA NA NA 0.15142684255492 94.5596154475865 a1247 loss_cnaBRCA38 273 CUDC-101 HDAC, EGFR 4 45 1.63315443905142 NA -1.25432750239479 0.0824785101364119 -1.3368060125312 0.63624355982898 1.5782318549694 0.870617173781179 2.10109162109323 0.847027645730237 0.101835944782054 NA NA NA 0.0116916933769417 94.5596154475865 a1248 gain_cnaBRCA63 140 Vinorelbine Microtubules 6 41 -2.74887219562247 NA -2.57522913398305 -3.74975682037453 1.17452768639147 2.19278549591028 1.52146776536148 0.729546547488672 0.535632732240369 0.77197014168251 0.102049520039296 NA NA NA 0.253876671608718 94.6208113233631 a1249 loss_cnaBRCA20 1054 PD-0332991 CDK4, CDK6 3 39 1.38629436111989 0.693147180559945 4.21326206112339 2.78056955963821 1.43269250148518 0.056829949842237 1.4662321313616 1.00246976788328 25.2101665664392 0.977125293356328 0.102098627164926 NA NA NA 4.4170135859754e-07 94.6208113233631 a1250 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1003 Camptothecin TOP1 6 39 -2.30258509299405 NA -1.54428458372731 -2.68081942253741 1.1365348388101 1.24240523736852 1.58804493138676 0.73239079227348 0.91478593668628 0.715681789820407 0.102162810104593 NA NA NA 0.0812091504906439 94.6208113233631 a1251 PIK3CA_mut 53 CGP-60474 CDK1,CDK2,CDK5,CDK7,CDK9 4 8 -1.36257783450257 NA -0.705038572390706 -2.19780653935035 1.49276796695965 2.14114002894845 0.812379456306395 1.10128652382765 0.697183718382383 1.83752550039453 0.102319639982484 NA NA NA 0.259935480552969 94.6208113233631 a1252 loss_cnaBRCA23 1378 Bleomycin (50 uM) DNA damage 3 45 3.91202300542815 NA 5.53207425978177 3.6980938367299 1.83398042305187 0.672319523875136 1.88143494205565 0.993805331106478 2.72784049536612 0.974777486086264 0.102377415070732 NA NA NA 0.0144791281236059 94.6208113233631 a1253 loss_cnaBRCA34 1066 AZD6482 PI3Kbeta 4 39 1.6094379124341 NA 3.08391094039756 1.85265191465461 1.23125902574295 0.795434387392228 1.44081297928551 0.877160014776192 1.54790771590795 0.854558532887123 0.102392155270899 NA NA NA 0.0413338095615119 94.6208113233631 a1254 ASH1L_mut 276 CAY10603 HDAC6 3 46 2.99573227355399 NA 2.07993893299488 1.11655718967972 0.963381743315153 1.04338340305306 0.967578911500857 0.992230643961262 0.923324772558376 0.995662195469728 0.102535386393975 NA NA NA 0.247262819220787 94.6776107700029 a1255 loss_cnaBRCA18 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 15 31 1.38629436111989 NA 3.37005588477765 2.61113506293258 0.75892082184507 1.18949698059864 1.55407705575669 0.52409292409174 0.638018283546319 0.48834182258456 0.102756125654129 NA NA NA 0.0758831631505116 94.7366196396259 a1256 NF1_mut 1066 AZD6482 PI3Kbeta 5 38 1.6094379124341 NA 2.95188581081222 1.8376220889226 1.11426372188962 1.53643021898071 1.38871230668913 0.793743540354189 0.725228980870237 0.802371892668086 0.102839573303475 NA NA NA 0.185135715459261 94.7366196396259 a1257 gain_cnaBRCA30_(CRNKL1,FOXA2) 176 IPA-3 PAK1, PAK2, PAK3 5 42 3.46573590279973 NA 5.53553908809158 4.37318473118367 1.16235435690791 1.55448337991633 1.46854927330786 0.787294703767229 0.747743187174171 0.791498370558416 0.103027507179214 NA NA NA 0.174084148799413 94.7366196396259 a1258 gain_cnaBRCA16 152 CP466722 ATM 16 33 2.77258872223978 NA 2.37618295431429 2.90175815164109 -0.525575197326795 0.58549107818608 1.19390570525421 0.505759163463429 0.897665595443554 0.440214997728727 0.103530816538055 NA NA NA 0.0442175444977059 94.7366196396259 a1259 loss_cnaBRCA60 192 LFM-A13 BTK 3 45 2.77258872223978 NA 5.55570143437744 4.74478803692098 0.810913397456462 0.106571782201101 0.837028470436792 0.990209015691631 7.60908169787637 0.968800257216219 0.103589914497088 NA NA NA 2.37885004705133e-06 94.7366196396259 a1260 BRCA1_mut 1261 rTRAIL TR10A (DR4), TR10B (DR5) 4 43 -2.30258509299405 NA -0.946678914283478 -0.0656222707317436 -0.881056643551735 1.35455279073323 0.985804194115436 0.868407717306536 0.650440979177202 0.893744060748604 0.103612686650392 NA NA NA 0.286196050585496 94.7366196396259 a1261 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1026 17-AAG HSP90 8 35 0 NA -1.82189322362233 -0.684621147735226 -1.13727207588711 1.37155188122145 1.8108238286267 0.652226048598777 0.829186333712944 0.628041258298217 0.103669351773075 NA NA NA 0.06845033455957 94.7366196396259 a1262 loss_cnaBRCA57 282 EKB-569 EGFR 5 42 0.916290731874155 2.99573227355399 3.03125160832937 1.40506933821921 1.62618227011016 1.01607859369893 2.14503471892256 0.785682309870506 1.60044929614176 0.758114661625141 0.103714060178061 NA NA NA 0.0175689235569213 94.7366196396259 a1263 gain_cnaBRCA30_(CRNKL1,FOXA2) 192 LFM-A13 BTK 5 43 2.77258872223978 NA 5.3708840507625 4.7285615281573 0.642322522605201 1.21108988286766 0.771274948901065 0.78432385642061 0.530367342417466 0.832806152359027 0.103728309626999 NA NA NA 0.305675678960215 94.7366196396259 a1264 gain_cnaBRCA14_(RAD21) 1192 GSK269962A ROCK1, ROCK2 21 25 1.6094379124341 NA 3.05043864300031 2.34664783400487 0.703790808995445 1.60504802894391 1.26796107474683 0.491796991101918 0.43848582491237 0.555057109411634 0.103733572688999 NA NA NA 0.111921655381292 94.7366196396259 a1265 CDH1_mut 177 GSK-650394 SGK3 4 43 2.77258872223978 NA 2.69699216025901 4.1369919880684 -1.43999982780939 1.37760446902641 1.67730556845871 0.867987042503294 1.04529265125503 0.858519672794396 0.103775211136119 NA NA NA 0.123784659794014 94.7366196396259 a1266 gain_cnaBRCA62 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 7 36 0.693147180559945 NA 3.44523536710025 2.80403767365244 0.641197693447812 0.925687088932278 0.934184937902078 0.687282614668544 0.692672179523854 0.686371260585474 0.103778358152332 NA NA NA 0.13014604682982 94.7366196396259 a1267 loss_cnaBRCA57 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 5 43 2.77258872223978 NA 0.531187709429859 -0.549052191185926 1.08023990061579 0.910572143793325 1.41439258240018 0.783967251001792 1.18633093267673 0.76374827898394 0.10388103079359 NA NA NA 0.0542155690982075 94.7366196396259 a1268 gain_cnaBRCA63 1023 GW 441756 NTRK1 6 39 0.693147180559945 NA 3.16251706698876 2.23571290226486 0.926804164723904 1.36817063266116 1.2588462541576 0.728596010117194 0.67740393091264 0.736233008330401 0.103897111223305 NA NA NA 0.166720729675812 94.7366196396259 a1269 CDH1_mut 291 KIN001-266 MAP3K8 (COT) 4 45 2.99573227355399 NA 2.86067668538611 3.86023065105739 -0.99955396567128 0.446711683857119 1.18837468472915 0.865153990488846 2.23758187169106 0.841110113262884 0.103941571800809 NA NA NA 0.00841498825542989 94.7366196396259 a1270 loss_cnaBRCA7_(FAS,PTEN) 1527 GDC0941 (rescreen) PI3K 4 41 1.38629436111989 NA 1.87630724508239 0.893275216610563 0.983032028471826 0.659631444503823 1.15741007612876 0.870078006417333 1.49027466271149 0.84933771421778 0.103985608938089 NA NA NA 0.0471010312050336 94.7366196396259 a1271 MLL3_mut 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 44 2.99573227355399 NA 2.55308367581775 3.93592908831429 -1.38284541249654 0.344916508595852 1.42673652151847 0.990176026455926 4.00921781948355 0.969236710240505 0.103990192211732 NA NA NA 0.00115123038904176 94.7366196396259 a1272 gain_cnaBRCA13_(FGFR1,WHSC1L1) 266 Zibotentan, ZD4054 Endothelin A Receptor 11 38 2.99573227355399 NA 5.95424310189327 5.68061199262686 0.273631109266413 0.543491808645098 0.46427481633034 0.567439716026301 0.503468690629512 0.589373146338653 0.10411337209784 NA NA NA 0.150709141156175 94.7742716604473 a1273 gain_cnaBRCA62 1011 ABT-263 BCL2, BCL2L1, BCL2L2 7 36 0.693147180559945 NA 2.61924575062145 1.49969449101547 1.11955125960598 1.40422518169073 1.66717426334226 0.686275628810324 0.797273310722153 0.671526237072283 0.104269546614713 NA NA NA 0.0923748554697514 94.8418759035163 a1274 gain_cnaBRCA62 156 AZD6482 PI3Kbeta 9 38 1.63315443905142 NA 2.76371991434823 1.88505477532697 0.878665139021268 1.46632032421473 1.42222540168729 0.614380743185488 0.599231371557118 0.617810044722055 0.104415054560945 NA NA NA 0.130330314747717 94.8435471272159 a1275 loss_cnaBRCA18 175 PAC-1 CASP3 agonist 16 32 0.940007258491471 NA 1.99675889821373 2.60369325170967 -0.606934353495936 1.18161859055319 1.20400721051475 0.507151065073325 0.513646584734072 0.504095281320162 0.104458007753808 NA NA NA 0.105717761105452 94.8435471272159 a1276 gain_cnaBRCA27_(CLTC,PPM1D) 1203 QL-XII-61 BTK 6 17 2.30258509299405 NA 3.36807324531781 4.52773025904095 -1.15965701372314 2.30370744009853 1.03027133675039 0.805566371071752 0.503387276325997 1.12558407902606 0.104578285101512 NA NA NA 0.280451190958561 94.8435471272159 a1277 loss_cnaBRCA33 1054 PD-0332991 CDK4, CDK6 5 37 1.38629436111989 0.693147180559945 3.87957912868639 2.74821900988725 1.13136011879914 0.392942924159933 1.50150504599922 0.79123713660238 2.87919707733091 0.753484060419021 0.104611815217532 NA NA NA 0.000994022045489006 94.8435471272159 a1278 gain_cnaBRCA58_(CCND1) 302 PI-103 PI3Ka, PRKDC (DNAPK) 10 38 2.32630161961136 NA 1.97335643297441 0.906084929517985 1.06727150345642 1.86993427761542 1.80115593239581 0.588087451537618 0.570753483816247 0.592548087736516 0.10479853841689 NA NA NA 0.128367155556843 94.8435471272159 a1279 gain_cnaBRCA19 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 4 43 2.99573227355399 NA 2.74219776676205 3.9504962754938 -1.20829850873176 0.427362840531373 1.44129170643938 0.865056625188133 2.82733638523505 0.838344176500382 0.104913172975235 NA NA NA 0.00203045159111898 94.8435471272159 a1280 POLR2B_mut 167 OSU-03012 PDPK1 (PDK1) 3 45 2.77258872223978 NA 1.17633825845334 2.31942174552637 -1.14308348707303 2.04465403150553 1.10204506906375 0.986199671998842 0.559059610799464 1.03723842078813 0.104955536771374 NA NA NA 0.43544558206999 94.8435471272159 a1281 gain_cnaBRCA14_(RAD21) 1502 Bicalutamide ANDR (androgen receptor) 19 26 2.30258509299405 NA 4.72302022617217 4.43793294943967 0.285087276732508 0.707063504002597 0.446672241868328 0.499865162802478 0.403198970274473 0.638247130692637 0.104964067566217 NA NA NA 0.133116379991198 94.8435471272159 a1282 gain_cnaBRCA63 154 CHIR-99021 GSK3B 6 41 0.940007258491471 NA 3.83411602655846 3.19367893233398 0.640437094224484 0.944300228331685 0.879011140370305 0.722430852234056 0.678213427265561 0.728588142756285 0.10533699176929 NA NA NA 0.166008918901079 94.8435471272159 a1283 gain_cnaBRCA19 190 Bleomycin DNA damage 4 44 4.15888308335967 NA -0.0453902057769413 2.27147091652091 -2.31686112229785 2.94464662921839 2.66684943089524 0.862619839566115 0.786804467235113 0.868763378785915 0.105388316710946 NA NA NA 0.21431626154767 94.8435471272159 a1284 BRCA1_mut 173 FH535 unknown 4 44 3.46573590279973 NA 0.582065961875587 1.66308280731742 -1.08101684544183 1.12338233693792 1.26179203422025 0.862583622828838 0.962287557759219 0.856731391643211 0.105402526069467 NA NA NA 0.147684239333324 94.8435471272159 a1285 gain_cnaBRCA62 300 CX-5461 RNA Pol I 10 39 2.32630161961136 NA 3.1333082728844 4.11212350356714 -0.978815230682734 1.99296659603329 1.58763812835358 0.585109960781558 0.491134790031565 0.616522879617276 0.105464661034306 NA NA NA 0.175160633792491 94.8435471272159 a1286 gain_cnaBRCA31 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 15 30 -0.669430653942629 NA -2.65792135372487 -3.90032655847386 1.242405204749 3.06056661025587 1.96253832909711 0.522808521107311 0.405939606276084 0.633060351652128 0.105560524686612 NA NA NA 0.167666094187856 94.8435471272159 a1287 gain_cnaBRCA63 290 KIN001-260 IKK 7 42 2.99573227355399 NA 5.63309385770639 4.94590359789578 0.687190259810617 1.19599920436194 0.992258703734617 0.673362438758783 0.574574178063293 0.692551506199142 0.105735691093575 NA NA NA 0.19062522064242 94.8435471272159 a1288 loss_cnaBRCA7_(FAS,PTEN) 176 IPA-3 PAK1, PAK2, PAK3 4 43 3.46573590279973 NA 5.66271540097745 4.38838587316889 1.27432952780857 0.789608043670409 1.51430631665846 0.862725974996012 1.61387607183557 0.841526918160498 0.105825520733584 NA NA NA 0.035811834809326 94.8435471272159 a1289 gain_cnaBRCA16 1091 BMS-536924 IGF1R 16 31 1.38629436111989 NA 3.38216625839447 2.83808206992996 0.54408418846451 1.10778932059791 1.0521633806403 0.508002586483798 0.491144099647803 0.517109983559209 0.105849195798604 NA NA NA 0.115431923879945 94.8435471272159 a1290 gain_cnaBRCA12_(TERT) 1042 BIRB 0796 p38, JNK2 9 34 2.30258509299405 NA 3.92468626399937 4.48357154329937 -0.558885279299998 0.955305720710329 0.888741730318309 0.619527351981642 0.585032903272507 0.628850047470854 0.106036151438944 NA NA NA 0.139526603676844 94.8435471272159 a1291 gain_cnaBRCA63 346 THZ-2-102-1 CDK7 7 41 0.916290731874155 2.99573227355399 0.0992887811001011 -1.58006312498251 1.67935190608261 3.51121866714149 2.29970260759709 0.674069182550484 0.478281777719583 0.730247424399511 0.106114561178657 NA NA NA 0.261961551011497 94.8435471272159 a1292 ASH1L_mut 1262 UNC1215 LMBL3 3 43 0 NA 2.22256536815316 2.79484274763823 -0.572277379485075 0.791457754733412 0.569052234328298 0.984967471312234 0.723067499260066 1.00566757313691 0.106178871913234 NA NA NA 0.336284174826779 94.8435471272159 a1293 gain_cnaBRCA15 1495 AZD-2281 PARP1, PARP2 21 24 2.30258509299405 NA 4.28914760754262 3.74454202519144 0.544605582351178 1.16281490244549 1.05140268441453 0.49302483122095 0.468351051578225 0.517980018906305 0.106234761096335 NA NA NA 0.108976391301992 94.8435471272159 a1294 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 55 A-770041 SRC family 3 9 1.63315443905142 NA 1.74941988793275 3.02344519728408 -1.27402530935133 0.823874103141365 1.13096005406096 1.18340778615892 1.54638348807612 1.12649894642756 0.106267268166046 NA NA NA 0.0918680916462451 94.8435471272159 a1295 gain_cnaBRCA27_(CLTC,PPM1D) 55 A-770041 SRC family 3 9 1.63315443905142 NA 1.74941988793275 3.02344519728408 -1.27402530935133 0.823874103141365 1.13096005406096 1.18340778615892 1.54638348807612 1.12649894642756 0.106267268166046 NA NA NA 0.0918680916462451 94.8435471272159 a1296 gain_cnaBRCA47_(EGFR) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 37 1.6094379124341 NA 1.58814327758871 2.72613028202391 -1.1379870044352 1.2476684256552 1.60500448280504 0.726777145046865 0.912090889723041 0.709024190665409 0.10630385321001 NA NA NA 0.0827265240343966 94.8435471272159 a1297 loss_cnaBRCA22_(SYNCRIP,ZNF292) 290 KIN001-260 IKK 19 30 2.99573227355399 NA 5.3456358472835 4.85308423390603 0.492551613377475 0.831812465034682 1.1219895863638 0.482585064562694 0.592142621181973 0.438998382305632 0.106448614526461 NA NA NA 0.0852092219176838 94.8435471272159 a1298 gain_cnaBRCA27_(CLTC,PPM1D) 1026 17-AAG HSP90 10 33 0 NA -1.69393582525466 -0.654470536580757 -1.0394652886739 1.46159830436432 1.81624972013742 0.595823350475908 0.711183972757815 0.572314080574371 0.10646244548612 NA NA NA 0.0796261758667836 94.8435471272159 a1299 BRCA1_mut 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 4 41 -0.669430653942629 NA -5.35647602324305 -3.30372470651504 -2.05275131672801 1.29188434803842 2.43878038696589 0.863664939556221 1.58895904253727 0.841712245882811 0.106482319892697 NA NA NA 0.0377358281454646 94.8435471272159 a1300 loss_cnaBRCA17 273 CUDC-101 HDAC, EGFR 11 38 1.63315443905142 NA -0.698137727911414 0.167729946146972 -0.865867674058387 1.00117999092705 1.65182736069609 0.563481096445555 0.864847162253646 0.524187753914855 0.106482952988497 NA NA NA 0.0409662847387355 94.8435471272159 a1301 loss_cnaBRCA38 274 PXD101, Belinostat HDAC 4 44 2.99573227355399 NA -0.482435218324347 0.776406851810432 -1.25884207013478 0.510466044168161 1.50878209499661 0.859532194819869 2.46606426522679 0.834343192638169 0.10660538055994 NA NA NA 0.00482721740242221 94.8796081094193 a1302 gain_cnaBRCA16 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 16 30 2.30258509299405 NA 1.73682078802591 1.2405637831569 0.496257004869007 0.920495390963902 0.999811334713517 0.509766801481443 0.539119489071367 0.496350649006398 0.106745669387426 NA NA NA 0.100538774165205 94.8981292317917 a1303 gain_cnaBRCA14_(RAD21) 155 AP-24534 ABL 21 26 -0.669430653942629 NA 1.74196127828173 1.20579699688619 0.536164281395537 0.97347696006772 1.20918569890742 0.482761477688845 0.550772440837468 0.443409380279634 0.106848899109825 NA NA NA 0.0990937802568114 94.8981292317917 a1304 gain_cnaBRCA58_(CCND1) 1031 Elesclomol HSP70 8 36 -1.6094379124341 NA -2.05833054474189 -3.18185652075493 1.12352597601304 2.08634192543833 1.66787216312207 0.644001424999065 0.538514786245787 0.67362835165372 0.10689339109308 NA NA NA 0.187480554656282 94.8981292317917 a1305 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1016 Temsirolimus MTOR 8 36 -1.6094379124341 NA -2.52238763912895 -1.5795083635567 -0.942879275572259 1.62706983794763 1.42959272769437 0.643886594328816 0.579495270320787 0.659543978719676 0.106954019040926 NA NA NA 0.162314081576365 94.8981292317917 a1306 loss_cnaBRCA22_(SYNCRIP,ZNF292) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 17 30 2.77258872223978 NA 5.33043526919117 4.82983233736114 0.500602931830022 0.889752652246821 1.06036721134 0.499088353074643 0.562631570207618 0.472103368037385 0.107136431316434 NA NA NA 0.0922500599320862 94.9183735876656 a1307 gain_cnaBRCA31 312 AV-951 VEGFR 16 32 -2.05572501506252 NA 0.842994093056582 0.526916726096984 0.316077366959598 0.653828974263794 0.615602154155181 0.503049163578395 0.483425145414362 0.513444218520264 0.107212180240554 NA NA NA 0.118494103993599 94.9183735876656 a1308 loss_cnaBRCA29_(MAP2K4) 298 OSI-930 KIT, VEGFR, PDGFR 7 41 2.32630161961136 NA 4.40441334279523 3.82953016657708 0.574883176218151 0.914384689991816 0.846614805839292 0.671781810771448 0.628710413144927 0.679037470468332 0.107272103172888 NA NA NA 0.159555652396907 94.9183735876656 a1309 gain_cnaBRCA30_(CRNKL1,FOXA2) 231 FMK RSK 5 44 2.99573227355399 2.32630161961136 5.99357862386987 5.5432809557195 0.450297668150363 0.977554743993381 0.529680642585733 0.774520880237557 0.460636778571463 0.850130497410953 0.10744375587784 NA NA NA 0.364854316350706 94.9183735876656 a1310 gain_cnaBRCA19 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 4 45 1.63315443905142 NA 2.80661252077278 3.64510528729763 -0.838492766524844 0.81742580992928 0.989837990545676 0.855832018203261 1.02577231638598 0.847101015048534 0.1076168030179 NA NA NA 0.129045470794009 94.9183735876656 a1311 gain_cnaBRCA47_(EGFR) 309 Y-39983 ROCK 7 42 2.99573227355399 NA 4.32572427462563 5.03652370268987 -0.71079942806424 0.904237214375835 1.08254402980316 0.669649104945007 0.786076282599009 0.656600940465661 0.107619817062762 NA NA NA 0.0940422973007507 94.9183735876656 a1312 gain_cnaBRCA14_(RAD21) 1004 Vinblastine Microtubules 20 25 -2.30258509299405 NA -3.11196760330314 -3.73043455752799 0.618466954224845 1.18801324209933 1.30548944436006 0.492826646769729 0.520589276540351 0.473743358781435 0.107727471339552 NA NA NA 0.10424015564533 94.9183735876656 a1313 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 226 GSK1070916 AURKB 6 43 0.940007258491471 2.32630161961136 1.20767959454238 2.57086884148835 -1.36318924694597 1.98892312265309 1.89873933123349 0.714259151288784 0.685390617374674 0.717944387900992 0.107899978637909 NA NA NA 0.16224243064962 94.9183735876656 a1314 gain_cnaBRCA16 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 16 31 2.32630161961136 NA 0.91737077907357 1.67477653259571 -0.757405753522137 1.67584273994296 1.40447959282657 0.504803516892017 0.451955147980004 0.539278575061263 0.108001440296271 NA NA NA 0.133466599080107 94.9183735876656 a1315 loss_cnaBRCA7_(FAS,PTEN) 294 MPS-1-IN-1 MPS1 4 45 2.99573227355399 NA 5.65828686812451 4.67636044382794 0.981926424296569 0.158228973516322 1.18653004973938 0.85479045539564 6.20573086252929 0.827561362236254 0.1080339621879 NA NA NA 9.58197244977168e-06 94.9183735876656 a1316 NF1_mut 1046 681640 WEE1, CHEK1 4 32 0.693147180559945 NA 1.8274411261042 2.73458910328804 -0.907147977183846 1.63311558668178 0.959446676914965 0.875076357973381 0.555470772908991 0.945490769847386 0.10814033401564 NA NA NA 0.350441840806712 94.9183735876656 a1317 BRCA1_mut 263 FR-180204 ERK 4 45 2.99573227355399 NA 5.92161086708837 5.30777591357251 0.61383495351586 0.245640828925348 0.739681790366595 0.854481337927988 2.49891256352342 0.82986354606842 0.108158021591076 NA NA NA 0.00445480577270841 94.9183735876656 a1318 loss_cnaBRCA28_(GPS2) 154 CHIR-99021 GSK3B 4 43 0.940007258491471 NA 3.97058732785508 3.2107716993866 0.759815628468481 0.424654069999597 0.911017134055447 0.856680863192239 1.78925785044095 0.834030008948477 0.108222259058107 NA NA NA 0.0239876003076631 94.9183735876656 a1319 gain_cnaBRCA9_(KRAS) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 4 39 -1.38629436111989 0.693147180559945 -1.4929852249565 -2.29512919380528 0.802143968848776 1.01611870306153 0.923336781680269 0.862112998888978 0.789419549538797 0.868744736226202 0.108224423159168 NA NA NA 0.213360844677879 94.9183735876656 a1320 gain_cnaBRCA47_(EGFR) 1007 Docetaxel Microtubules 7 38 -4.38202663467388 NA -5.44707806813066 -4.42889573741598 -1.01818233071468 0.502462186734622 1.61460769164288 0.674540811697489 2.02638598007064 0.630606639609566 0.108302411126694 NA NA NA 0.00356601232808506 94.9183735876656 a1321 TP53_mut 29 AZ628 BRAF 9 5 1.38629436111989 NA 3.13930387943282 1.31029821592381 1.82900566350902 1.06518601405853 2.90902898205371 0.967033625394825 1.71707630345258 0.628734080957068 0.108555301690748 NA NA NA 0.237703725542367 94.9183735876656 a1322 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1006 Cytarabine DNA synthesis 7 38 0.693147180559945 NA 2.05917431930573 1.05183624027865 1.00733807902708 1.73102820728583 1.4529624890687 0.673863016011206 0.581930482003258 0.693299439321897 0.108646951974254 NA NA NA 0.187251230143396 94.9183735876656 a1323 loss_cnaBRCA29_(MAP2K4) 178 BAY 61-3606 SYK 7 41 2.07944154167984 NA 3.99505904577896 2.94221273461571 1.05284631116325 1.53220760932473 1.57970132435914 0.669073769257035 0.687143377147998 0.666484413811816 0.108655861387715 NA NA NA 0.131435747126904 94.9183735876656 a1324 TP53_mut 298 OSI-930 KIT, VEGFR, PDGFR 37 11 2.32630161961136 NA 4.02357173307232 3.5426796459592 0.480892087113123 0.868830368606952 0.807890354324081 0.561821527311583 0.553493644431613 0.595244248850402 0.108671191580399 NA NA NA 0.106274636021137 94.9183735876656 a1325 BRCA1_mut 299 OSI-027 MTORC1/2 4 44 2.99573227355399 NA 2.79157245659222 1.13055111881574 1.66102133777648 2.24211831324166 1.92169080705235 0.854347525751787 0.74082680114011 0.86435410508327 0.108674895950227 NA NA NA 0.236315734634549 94.9183735876656 a1326 loss_cnaBRCA33 1069 EHT 1864 Rac GTPases 5 41 2.30258509299405 NA 2.98049526015709 3.63226637963654 -0.651771119479449 0.562920718412004 0.863205007275043 0.775592876255888 1.15783821444358 0.755059474848221 0.108698301560795 NA NA NA 0.0588540151764492 94.9183735876656 a1327 loss_cnaBRCA36_(FAT1,IRF2) 1377 Afatinib (rescreen) ERBB2, EGFR 9 38 2.30258509299405 NA 3.788875899027 2.60863692154958 1.18023897747742 1.24019839578483 2.06773106785315 0.606339288487394 0.951653365694394 0.570789400917029 0.108897761657322 NA NA NA 0.0383055108529479 94.9513113697837 a1328 loss_cnaBRCA57 134 Etoposide TOP2 5 42 2.77258872223978 NA 3.93843541444542 2.30313339721136 1.63530201723406 1.30221053850833 2.17695714793956 0.773590834497116 1.2557892666936 0.751187049677037 0.108983127042895 NA NA NA 0.0451229625589134 94.9513113697837 a1329 gain_cnaBRCA30_(CRNKL1,FOXA2) 223 ZSTK474 PI3K 5 44 1.63315443905142 2.32630161961136 -0.0698763883484783 1.02395322834174 -1.09382961669022 0.950874518285538 1.45459126637369 0.771007457077028 1.1503406555288 0.751984177257675 0.109004118410216 NA NA NA 0.0597722690513443 94.9513113697837 a1330 loss_cnaBRCA36_(FAT1,IRF2) 255 CP724714 ERBB2 9 39 2.32630161961136 NA 4.60524967975406 3.61790937878855 0.98734030096551 0.498890818366192 1.78371678172608 0.604061320208268 1.97907090011985 0.553529748153222 0.109194934851904 NA NA NA 0.00458447805609897 94.9513113697837 a1331 NF1_mut 230 GSK429286A ROCK2 5 44 2.99573227355399 2.32630161961136 4.79734737966479 5.47461224582806 -0.677264866163274 1.11847564383696 0.853438827377737 0.770397031376376 0.60552491231718 0.793571659077461 0.109277094421573 NA NA NA 0.252083196716428 94.9513113697837 a1332 loss_cnaBRCA57 310 YM201636 FYV1 5 44 1.63315443905142 NA 3.10388609498032 2.33634718707434 0.767538907905981 0.991304365068583 0.997216124572129 0.770069076736998 0.774271691876267 0.769681605615137 0.109423982537947 NA NA NA 0.162400966105229 94.9513113697837 a1333 loss_cnaBRCA33 305 TPCA-1 IKK 6 43 2.99573227355399 NA 3.33407008330176 4.29612956784788 -0.962059484546114 1.37130063109058 1.351322249638 0.710814008650457 0.701567156562161 0.711939350368747 0.109563237672714 NA NA NA 0.154608498658764 94.9513113697837 a1334 gain_cnaBRCA31 333 T0901317 LXR 16 32 2.32630161961136 NA 4.98475994665176 4.61077433571868 0.373985610933085 0.809576893040621 0.717744804861093 0.499361021272402 0.461951933346892 0.521056520925238 0.109738999186831 NA NA NA 0.12905324030147 94.9513113697837 a1335 loss_cnaBRCA22_(SYNCRIP,ZNF292) 166 FTI-277 Farnesyl transferase (FNTA) 17 30 0.0237165266173161 NA 2.49664998488531 2.10143941049999 0.395210574385321 0.780792260280912 0.807513410354187 0.49517994873834 0.506166101394412 0.489416732053992 0.109834506342134 NA NA NA 0.108736916243056 94.9513113697837 a1336 loss_cnaBRCA42 300 CX-5461 RNA Pol I 3 46 2.32630161961136 NA 2.38686807022696 4.0118542425496 -1.62498617232264 2.1727938602817 1.64841049943668 0.970677540575465 0.747878665356666 0.98578974889929 0.110002028798849 NA NA NA 0.323549649266528 94.9513113697837 a1337 gain_cnaBRCA64_(SDHC) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 7 40 2.32630161961136 NA 0.563777898446974 1.56623899216288 -1.00246109371591 1.03811051042502 1.5599536029323 0.667909094165578 0.965659323982259 0.642622377890949 0.110034783755147 NA NA NA 0.0525735970731539 94.9513113697837 a1338 gain_cnaBRCA19 287 KIN001-244 PDPK1 (PDK1) 4 45 2.99573227355399 NA 2.75696492557058 3.542207474416 -0.785242548845412 0.654209579316814 0.939629864158635 0.849784207306807 1.20029203740097 0.835693477610501 0.110057499007116 NA NA NA 0.0888623381659573 94.9513113697837 a1339 gain_cnaBRCA64_(SDHC) 211 TL-2-105 CRAF 8 41 2.32630161961136 1.63315443905142 3.34601965791654 4.01712136161297 -0.671101703696436 1.04370430416761 1.07071758920056 0.629115958574349 0.642999842979148 0.626777509275349 0.110278578085835 NA NA NA 0.128322335641998 94.9513113697837 a1340 gain_cnaBRCA14_(RAD21) 1032 Afatinib ERBB2, EGFR 20 25 -0.693147180559945 NA -0.196541672033821 0.680082394738309 -0.87662406677213 2.06182247884231 1.54555453081039 0.489158301971227 0.425169516661951 0.56719064212667 0.110294284775122 NA NA NA 0.123416269565526 94.9513113697837 a1341 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1032 Afatinib ERBB2, EGFR 8 37 -0.693147180559945 NA 1.2272541251325 0.087924146668144 1.13932997846435 1.48768107095799 1.84547955047703 0.635748549292192 0.765842895164811 0.617362559324947 0.110296829166297 NA NA NA 0.0847848194100847 94.9513113697837 a1342 loss_cnaBRCA42 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 3 45 2.32630161961136 NA 4.33794256456887 4.9998602594044 -0.661917694835527 0.520054793373193 0.688212926081688 0.970888764615918 1.27278452822669 0.961792011963692 0.110306970604387 NA NA NA 0.146522175565336 94.9513113697837 a1343 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 309 Y-39983 ROCK 15 34 2.99573227355399 NA 5.30663277471754 4.77101687689973 0.535615897817817 1.00346657570052 1.08574897074646 0.504390945217024 0.533765559100865 0.493314672404963 0.110370535185981 NA NA NA 0.103982278413962 94.9513113697837 a1344 BRCA1_mut 1005 Cisplatin DNA crosslinker 4 41 1.79175946922805 2.30258509299405 2.76991521355283 3.75790485285769 -0.987989639304863 1.13818027554394 1.15842378354409 0.853906699605489 0.868043191868443 0.852874097838528 0.11037553217948 NA NA NA 0.180495297564577 94.9513113697837 a1345 gain_cnaBRCA12_(TERT) 155 AP-24534 ABL 9 38 -0.669430653942629 NA 0.902986773178319 1.57381652116717 -0.670829747988849 1.42793421164087 1.03008056376388 0.603660644559253 0.469790374458488 0.651240079259098 0.110425458768848 NA NA NA 0.212944978160776 94.9513113697837 a1346 gain_cnaBRCA9_(KRAS) 164 JQ12 HDAC 4 43 1.63315443905142 NA 2.8295840427988 1.46144588093631 1.36813816186249 2.04306213879331 1.57177203376022 0.851099011656641 0.669650783441442 0.870443125641718 0.110474580384925 NA NA NA 0.274891373322025 94.9513113697837 a1347 gain_cnaBRCA9_(KRAS) 276 CAY10603 HDAC6 4 45 2.99573227355399 NA 0.417871888940203 1.2428879992998 -0.825016110359598 0.890327128823032 0.977498496374635 0.848635389043291 0.926643796028352 0.844007549289777 0.110526188241209 NA NA NA 0.159297370561356 94.9513113697837 a1348 loss_cnaBRCA28_(GPS2) 197 Bryostatin 1 PRKC 4 44 -4.8283137373023 NA -2.06985729232286 -2.87379907134217 0.803941779019312 0.268618239787205 0.976830314269117 0.848999728193761 2.99287859103009 0.823010677776556 0.110843799559231 NA NA NA 0.00137515149095302 94.9513113697837 a1349 gain_cnaBRCA13_(FGFR1,WHSC1L1) 207 AS601245 JNK 10 38 2.07944154167984 NA 2.84136672740886 2.11484123571408 0.72652549169477 1.46066952407503 1.20300713209696 0.577717021274528 0.497392106647013 0.603924509099429 0.110889300328814 NA NA NA 0.172176522969589 94.9513113697837 a1350 gain_cnaBRCA64_(SDHC) 202 GSK-1904529A IGF1R 8 40 0.0237165266173161 NA 2.61770541238234 2.10406822740671 0.513637184975633 0.993566318658369 0.779953957257026 0.629399378575123 0.516963161220287 0.65854808504596 0.110973784521073 NA NA NA 0.2017091778785 94.9513113697837 a1351 gain_cnaBRCA15 202 GSK-1904529A IGF1R 22 26 0.0237165266173161 NA 2.397725597428 2.01363112507351 0.38409447235449 0.925470253367384 0.711319629886932 0.470654738397524 0.415026275514461 0.539974515275986 0.111054449732141 NA NA NA 0.120012878421959 94.9513113697837 a1352 loss_cnaBRCA33 192 LFM-A13 BTK 6 42 2.77258872223978 NA 4.28678039292654 4.86814008588136 -0.581359692954821 0.821579903374284 0.819725347862236 0.709038241851484 0.707611871428619 0.70921278019638 0.111078867165559 NA NA NA 0.152110856091813 94.9513113697837 a1353 gain_cnaBRCA27_(CLTC,PPM1D) 1005 Cisplatin DNA crosslinker 10 35 1.79175946922805 2.30258509299405 4.19504551280668 3.52009441980886 0.674951092997829 1.18664146750898 1.14923656538971 0.583279628010667 0.568791089371499 0.587303879222594 0.111110288538882 NA NA NA 0.132199283200476 94.9513113697837 a1354 gain_cnaBRCA27_(CLTC,PPM1D) 298 OSI-930 KIT, VEGFR, PDGFR 9 39 2.32630161961136 NA 3.49564897128527 4.00976383301691 -0.514114861731635 0.946202286577243 0.836152422426969 0.600385382019703 0.543345613326908 0.614857827283923 0.111308019798275 NA NA NA 0.161478462644709 94.9513113697837 a1355 gain_cnaBRCA8_(CHD4,WNK1) 326 GSK690693 AKT 4 44 2.32630161961136 NA 1.47018807716328 3.07315917535902 -1.60297109819574 3.27973675811548 1.75353936704847 0.847683812539175 0.488749926111996 0.914134651504195 0.111382872394201 NA NA NA 0.402472688259772 94.9513113697837 a1356 ASH1L_mut 207 AS601245 JNK 3 45 2.07944154167984 NA 1.12519979463715 2.34226744105138 -1.21706764641424 0.741872893035133 1.27619211710453 0.967700831068096 1.64053392143093 0.953671183281997 0.111448759079571 NA NA NA 0.0845715673793853 94.9513113697837 a1357 gain_cnaBRCA16 86 A-443654 AKT1, AKT2, AKT3 3 9 0.0237165266173161 NA -2.26535691833316 -0.945053832122877 -1.32030308621028 1.20214273083784 1.11716908237052 1.16359786163938 1.09829145270469 1.18182923878338 0.111507914108176 NA NA NA 0.18522927886274 94.9513113697837 a1358 gain_cnaBRCA63 1264 SGC0946 Q8TEK3 (DOT1L) 6 40 -0.693147180559945 NA 2.31808933829947 1.89560731207436 0.422482026225108 0.793471964462423 0.563601560434154 0.710987593608451 0.532447326618956 0.749611171941506 0.111517101758745 NA NA NA 0.256978767077169 94.9513113697837 a1359 BRCA1_mut 258 STF-62247 stimulates autophagy 4 45 2.32630161961136 NA 5.36321579964588 4.56574309255867 0.797472707087216 0.197956361900834 0.972674009651161 0.846172168349941 4.02852779991334 0.819876648470561 0.111536605494974 NA NA NA 0.0001512647904411 94.9513113697837 a1360 PIK3CA_mut 1006 Cytarabine DNA synthesis 16 29 0.693147180559945 NA 1.6961091758079 0.939525881131123 0.756583294676772 1.71225407969189 1.36549512908366 0.505867148582422 0.441863917072936 0.554072496168106 0.111602288517261 NA NA NA 0.140557694789779 94.9513113697837 a1361 gain_cnaBRCA30_(CRNKL1,FOXA2) 157 JNK-9L JNK 5 42 1.63315443905142 NA 0.765318522347249 -0.0286169193788943 0.793935441726143 0.75359298436097 1.05749897400796 0.767749010462313 1.05353348319635 0.750767103552924 0.111606127277205 NA NA NA 0.0777730172284681 94.9513113697837 a1362 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 36 -1.38629436111989 0.693147180559945 0.715840162466456 -0.471917557359728 1.18775771982618 1.31334305346192 1.70015288045759 0.716921218717911 0.904377357229931 0.698618185151976 0.111841103894229 NA NA NA 0.0854328023995072 95.0813613796826 a1363 TP53_mut 87 GW843682X PLK1 9 3 -1.36257783450257 NA -1.40571018820221 -3.44167839866618 2.03596821046397 1.92662783079682 0.707578189750256 1.16205482393887 1.05675220606666 2.87737558895445 0.111925847848566 NA NA NA 0.0242136369799816 95.0835944415661 a1364 gain_cnaBRCA64_(SDHC) 262 VX-11e ERK 8 41 1.63315443905142 NA 3.09348538291756 3.91014395663971 -0.816658573722148 2.55125450854121 0.927795944596841 0.625978424602557 0.3201007860988 0.880213562559831 0.112017392829753 NA NA NA 0.399631439271741 95.0915976228526 a1365 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 175 PAC-1 CASP3 agonist 9 39 0.940007258491471 NA 2.98422281354096 2.26688002831437 0.717342785226584 0.856942558558265 1.25837791097559 0.598652207321188 0.837095529989144 0.570053541920842 0.112315823015113 NA NA NA 0.0558398584883837 95.2196311050057 a1366 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 5 40 2.30258509299405 NA 2.1022109272131 1.27321315134551 0.828997775867592 0.514706976101453 1.12071318771374 0.768445810752318 1.61062082769243 0.739705559777297 0.112538473041698 NA NA NA 0.0174818665240461 95.2196311050057 a1367 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1058 GDC0941 PI3K (class 1) 4 39 1.38629436111989 0.693147180559945 2.39258097892836 1.23866119422412 1.15391978470424 1.66094366972673 1.32845713381529 0.851253578491951 0.69473745903381 0.868616499043686 0.112600760025452 NA NA NA 0.260899681120762 95.2196311050057 a1368 gain_cnaBRCA31 309 Y-39983 ROCK 16 33 2.99573227355399 NA 5.28729250299931 4.76416319355651 0.523129309442798 0.913222016154151 1.1253716093564 0.492460109371351 0.57283913461247 0.464850281536758 0.112668088958078 NA NA NA 0.090579546051172 95.2196311050057 a1369 gain_cnaBRCA63 1020 Lenalidomide TNFA 6 39 1.6094379124341 NA 4.68255741609654 4.18890644777455 0.493650968321995 1.10813497154071 0.62071291236921 0.710108799147897 0.44547909866579 0.795296760361839 0.112695591584373 NA NA NA 0.331114703754764 95.2196311050057 a1370 gain_cnaBRCA61_(NOTCH2) 163 JQ1 BRD4 3 44 0.940007258491471 NA 1.6069520908813 0.227891607336778 1.37906048354452 2.25121579468541 1.37843199120457 0.965329594306911 0.612584758333767 1.00045594729661 0.112703857408679 NA NA NA 0.40006549466302 95.2196311050057 a1371 MLL3_mut 231 FMK RSK 3 46 2.99573227355399 2.32630161961136 5.0631662805244 5.62353818107466 -0.560371900550259 0.748503705267168 0.573335252215909 0.963062575233778 0.748656147734422 0.977389578583303 0.112743858921291 NA NA NA 0.323147133168299 95.2196311050057 a1372 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1007 Docetaxel Microtubules 8 37 -4.38202663467388 NA -3.80359734291203 -4.75672447987637 0.953127136964341 2.25349466042072 1.31842728232521 0.630951423037311 0.422955134398409 0.722927346651523 0.112929789163628 NA NA NA 0.281412170808281 95.241107920937 a1373 gain_cnaBRCA31 1529 MLN4924 NEDD8-activating enzyme 11 26 0 NA 1.04932155889892 0.0814779972712259 0.967843561627695 2.08872336269357 1.44542383155554 0.584820997935794 0.463366082322929 0.669591534675418 0.112933794952454 NA NA NA 0.1825308568006 95.241107920937 a1374 loss_cnaBRCA38 306 TG101348 JAK2 4 44 2.32630161961136 NA 2.25218903368277 3.31331619510934 -1.06112716142657 1.20142115687494 1.26152178437774 0.843711401728544 0.883226631522543 0.841148503789003 0.113023167171665 NA NA NA 0.174710448639426 95.2471071820021 a1375 loss_cnaBRCA17 330 XMD13-2 RIPK 10 38 2.32630161961136 NA 3.17946141448682 3.86353698902046 -0.684075574533644 0.765849603424023 1.27485105126412 0.573656105020849 0.893224428758888 0.536592548482686 0.11335170495439 NA NA NA 0.0420935726855448 95.3412832877206 a1376 BRCA1_mut 185 OSI-906 IGF1R 4 44 0.940007258491471 NA 3.74767472363458 2.81583674795687 0.931837975677711 0.282866895777327 1.14106365942481 0.842842070570097 3.29426309542865 0.816639779893993 0.113384742497227 NA NA NA 0.000701290499303215 95.3412832877206 a1377 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 9 17 2.30258509299405 NA 5.1087206064915 4.46188826986309 0.646832336628405 0.920395961132359 0.972007311176007 0.67723088960272 0.702776157158067 0.665460361451211 0.113454813618169 NA NA NA 0.112626781185203 95.3412832877206 a1378 ASH1L_mut 204 Tipifarnib Farnesyl-transferase (FNTA) 3 45 2.77258872223978 NA 0.28153243928364 1.7092061333825 -1.42767369409886 0.416052536677433 1.5148968761763 0.961956078432556 3.43147455727627 0.942423023342953 0.113530604264442 NA NA NA 0.00361027606965433 95.3412832877206 a1379 MLL3_mut 177 GSK-650394 SGK3 3 44 2.77258872223978 NA 2.51639015012115 4.11657849267304 -1.60018834255189 1.89148137093189 1.65019982719001 0.963001485510517 0.845997410888334 0.969693679629526 0.113549961690391 NA NA NA 0.277953274104061 95.3412832877206 a1380 loss_cnaBRCA28_(GPS2) 1170 CCT018159 HSP90 4 39 2.30258509299405 NA 4.2394928859629 3.25086282300476 0.988630062958147 0.635192828555966 1.19670463423052 0.848731064696912 1.55642510197365 0.826127044785642 0.113637771016182 NA NA NA 0.0403854241527452 95.3412832877206 a1381 gain_cnaBRCA19 276 CAY10603 HDAC6 4 45 2.99573227355399 NA 0.424388023833139 1.24230878730932 -0.817920763476179 0.681548033510424 0.98936954299209 0.840931666415556 1.20009261748339 0.826709058581479 0.113711298229849 NA NA NA 0.0888507681743319 95.3412832877206 a1382 loss_cnaBRCA17 221 TAK-715 p38a 11 38 2.99573227355399 2.32630161961136 4.05980148883407 4.60441227904501 -0.544610790210942 0.658984602223595 1.05859463006595 0.551665314621521 0.826439325552184 0.51446585382453 0.113819146372421 NA NA NA 0.0479422967777722 95.3563193625843 a1383 BRCA2_mut 153 Midostaurin KIT 6 41 -0.669430653942629 NA -0.2642447903069 0.74044194574857 -1.00468673605547 1.54896816175266 1.41016595878606 0.704422615916365 0.64861677655057 0.712459927000617 0.114046056901601 NA NA NA 0.182050231780505 95.3563193625843 a1384 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1377 Afatinib (rescreen) ERBB2, EGFR 18 29 2.30258509299405 NA 3.41566108614808 2.47400643308488 0.941654653063209 2.03914335010618 1.89075507754226 0.483360445320139 0.461789335710103 0.498031005838809 0.114203652850033 NA NA NA 0.122874396089903 95.3563193625843 a1385 loss_cnaBRCA36_(FAT1,IRF2) 1036 PLX4720 BRAF 9 34 2.30258509299405 NA 4.03421805652559 4.74548563821382 -0.711267581688233 1.09847870663388 1.19373882138859 0.604944017822181 0.64750238433643 0.595831825977536 0.114248629504774 NA NA NA 0.112970198917162 95.3563193625843 a1386 gain_cnaBRCA27_(CLTC,PPM1D) 1033 Vismodegib SMO 10 35 2.30258509299405 NA 5.1041356444125 4.66138569118742 0.442749953225078 0.565092512738489 0.810808415643373 0.578055159463881 0.783499946016755 0.54605988872693 0.114252706840838 NA NA NA 0.0627891539512095 95.3563193625843 a1387 loss_cnaBRCA28_(GPS2) 178 BAY 61-3606 SYK 4 44 2.07944154167984 NA 4.30956884534578 2.98540591041622 1.32416293492956 0.617281256481713 1.62079338451984 0.840760034321414 2.14515331710673 0.816984414902361 0.114254537252243 NA NA NA 0.0103892249602815 95.3563193625843 a1388 gain_cnaBRCA13_(FGFR1,WHSC1L1) 185 OSI-906 IGF1R 10 38 0.940007258491471 NA 3.39429748501408 2.76169844617104 0.632599038843039 0.664106165776674 1.18861242469866 0.572102091272582 0.952557093191888 0.532216411084055 0.114305701075453 NA NA NA 0.0354106004456711 95.3563193625843 a1389 gain_cnaBRCA12_(TERT) 186 Bexarotene Retinioic acid X family agonist 9 38 2.07944154167984 NA 4.14348045648992 3.47672980569355 0.666750650796366 0.418607251768732 1.21665458606336 0.59677888414337 1.59278332608706 0.548019674962737 0.114430615994765 NA NA NA 0.00882786798714671 95.3918000434402 a1390 loss_cnaBRCA17 256 JW-7-24-1 LCK 10 38 2.32630161961136 NA 1.32114868518579 1.97346924533807 -0.652320560152275 0.59144472578859 1.23832633155452 0.571712078503305 1.10292734334983 0.526775974579651 0.114546148558771 NA NA NA 0.0237162693583347 95.4065594601669 a1391 ASH1L_mut 164 JQ12 HDAC 3 44 1.63315443905142 NA 0.132278608149423 1.67644711879564 -1.54416851064622 1.35989162825887 1.61919125453372 0.959972669494378 1.1355085056471 0.953666533414484 0.114658455770239 NA NA NA 0.179345212375425 95.4065594601669 a1392 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 345 KIN001-270 CDK9 6 43 2.99573227355399 NA 4.69140707593941 5.16565860383767 -0.474251527898251 0.561132354619368 0.689576296789288 0.700445528469653 0.845168744938883 0.687743372425063 0.114695509775069 NA NA NA 0.10026990957525 95.4065594601669 a1393 BRCA2_mut 155 AP-24534 ABL 6 41 -0.669430653942629 NA 0.763841124248376 1.54509419554798 -0.781253071299599 1.69003889849692 1.01698304514032 0.702522421415832 0.462269283857565 0.76820658420299 0.114998264363032 NA NA NA 0.31541969414497 95.5073553751306 a1394 loss_cnaBRCA57 235 QL-XII-47 BTK, BMX 5 44 2.32630161961136 NA 2.71198321089722 1.59399462708465 1.11798858381257 2.31329946120651 1.37169985225031 0.7577429603012 0.483287443999784 0.815038787077568 0.115062554206374 NA NA NA 0.34483213433041 95.5073553751306 a1395 gain_cnaBRCA48 268 YM155 BIRC5 (Survivin) 5 44 1.63315443905142 NA -2.52901131905492 -3.71677876139975 1.18776744234483 1.80728287061703 1.54356316085597 0.757632580212134 0.657211696993127 0.769497143016916 0.115114093831003 NA NA NA 0.220700373624189 95.5073553751306 a1396 gain_cnaBRCA16 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 14 29 1.6094379124341 NA 3.12135670363853 2.2998857327406 0.821470970897924 1.54645859411029 1.57825898299655 0.523815206083597 0.531194934042534 0.520491870946455 0.115167957401794 NA NA NA 0.116892316273487 95.5073553751306 a1397 loss_cnaBRCA42 133 Doxorubicin DNA intercalating 3 45 0.0237165266173161 NA -2.64507848380209 -0.923016083516067 -1.72206240028602 1.31298624712927 1.81837579106669 0.957043498724962 1.31156164358246 0.947033285829128 0.115335872661951 NA NA NA 0.138065817954437 95.5073553751306 a1398 gain_cnaBRCA47_(EGFR) 1199 Tamoxifen ER 7 40 1.6094379124341 NA 4.39213561269567 3.77765127897293 0.614484333722738 0.289811241676349 0.996940234782148 0.657825484407941 2.12029157381332 0.616370282073144 0.115354806757735 NA NA NA 0.00295920847073438 95.5073553751306 a1399 gain_cnaBRCA13_(FGFR1,WHSC1L1) 64 CMK RSK 3 9 1.38629436111989 NA 1.26101165083204 2.51853808430001 -1.25752643346797 1.30721032690641 1.03396502592202 1.14938414655233 0.961992425843192 1.21621757210461 0.115411959218922 NA NA NA 0.230219593080663 95.5073553751306 a1400 loss_cnaBRCA42 221 TAK-715 p38a 3 46 2.99573227355399 2.32630161961136 3.59629405927901 4.53992610441409 -0.943632045135085 0.695716796235754 0.998443374404437 0.955621451448614 1.35634506776421 0.945103216993105 0.115476550241975 NA NA NA 0.129353330543533 95.5073553751306 a1401 loss_cnaBRCA36_(FAT1,IRF2) 176 IPA-3 PAK1, PAK2, PAK3 9 38 3.46573590279973 NA 3.7858443875857 4.66523301741844 -0.879388629832735 1.6580908663121 1.43793380223012 0.594394696435411 0.530362145826579 0.611564057030216 0.115845468545327 NA NA NA 0.170604864782885 95.7440885286468 a1402 gain_cnaBRCA31 257 NPK76-II-72-1 PLK3 16 33 2.32630161961136 NA 3.98964983131226 3.23135325016238 0.75829658114988 1.38611125785948 1.62766462546585 0.487758401991879 0.547067615857106 0.465880113928782 0.11605144250482 NA NA NA 0.0992565987784129 95.8430044471837 a1403 loss_cnaBRCA57 135 Gemcitabine DNA replication 5 42 0.0237165266173161 NA 1.55870109927698 -0.493548114140849 2.05224921341783 1.85174758743793 2.77817473133079 0.757654631476313 1.10827697432419 0.738704153584599 0.116259710098595 NA NA NA 0.0673225669403548 95.8430044471837 a1404 loss_cnaBRCA20 1023 GW 441756 NTRK1 3 42 0.693147180559945 NA 3.49897096977902 2.27788077811726 1.22109019166175 0.215859455774209 1.30455377985183 0.95793983749958 5.65687607838233 0.936021351147701 0.116269253043884 NA NA NA 5.12680320346407e-05 95.8430044471837 a1405 gain_cnaBRCA58_(CCND1) 258 STF-62247 stimulates autophagy 10 39 2.32630161961136 NA 5.05656202630335 4.52168415642795 0.534877869875394 0.479400127859163 1.02259242422686 0.567139993005274 1.11572325244045 0.523060661514085 0.116296244276961 NA NA NA 0.022553437856721 95.8430044471837 a1406 loss_cnaBRCA57 288 KIN001-055 JAK3, MNK1 5 44 2.32630161961136 NA 4.90771770281594 4.27438077221719 0.633336930598754 0.486365635518457 0.864592841550685 0.754810590589066 1.30218272909769 0.732526225249375 0.116438137563165 NA NA NA 0.0397853201078585 95.8916923786549 a1407 loss_cnaBRCA20 1028 VX-702 p38 3 42 0.693147180559945 NA 2.82862349310543 3.46956057028337 -0.640937077177941 0.701205227840354 0.668067339290115 0.957129639429355 0.914050625594973 0.959389928953864 0.116569536144151 NA NA NA 0.250297959850586 95.8977906616825 a1408 loss_cnaBRCA17 261 TL-1-85 MAP3K7 (TAK1) 11 38 2.32630161961136 NA 3.52019601827015 4.1708779113216 -0.650681893051448 1.01435579561872 1.23202083963489 0.547228002021252 0.641473037234 0.528141953543805 0.116678190478963 NA NA NA 0.0905756278523296 95.8977906616825 a1409 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 177 GSK-650394 SGK3 9 38 2.77258872223978 NA 4.81144417667408 3.82567438257659 0.985769794097483 0.890187835945774 1.78607444655628 0.592953807340648 1.10737279739411 0.55191976795712 0.116707405810335 NA NA NA 0.0252574472240026 95.8977906616825 a1410 gain_cnaBRCA62 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 4 22 2.30258509299405 NA 3.57868051170008 2.53024480325937 1.04843570844071 1.67302298031968 1.09894694321956 0.884008749569259 0.626671432953287 0.954036693863613 0.116937726271465 NA NA NA 0.30293613785688 95.8977906616825 a1411 gain_cnaBRCA63 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 4 22 2.30258509299405 NA 3.57868051170008 2.53024480325937 1.04843570844071 1.67302298031968 1.09894694321956 0.884008749569259 0.626671432953287 0.954036693863613 0.116937726271465 NA NA NA 0.30293613785688 95.8977906616825 a1412 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 5 21 2.30258509299405 NA 3.46638955513479 2.50705523537297 0.959334319761819 1.68809811969129 1.05743630008708 0.808836372874855 0.56829298520708 0.907226581575473 0.117131958690538 NA NA NA 0.280932864691799 95.8977906616825 a1413 gain_cnaBRCA64_(SDHC) 1004 Vinblastine Microtubules 9 36 -2.30258509299405 NA -2.85640164027101 -3.6053500344951 0.74894839422408 1.37489479492635 1.22833310294458 0.595871858751588 0.544731420169643 0.609727436660859 0.117167718886129 NA NA NA 0.162804353546733 95.8977906616825 a1414 POLR2B_mut 329 QL-XI-92 DDR1 3 45 2.32630161961136 NA 3.42519369359651 4.30854452516573 -0.883350831569224 0.592536407306358 0.940922100224149 0.951377090947869 1.49079587461114 0.938813990402383 0.11744703798392 NA NA NA 0.105514235888221 95.8977906616825 a1415 loss_cnaBRCA36_(FAT1,IRF2) 206 Ruxolitinib JAK1, JAK2, TYK2 9 40 1.65632149833295 0.0237165266173161 4.06230400965836 4.43955065193223 -0.377246642273865 0.924153236254867 0.565870581540513 0.588387590655087 0.408207889638149 0.666665938432171 0.117451671299654 NA NA NA 0.268530564794096 95.8977906616825 a1416 gain_cnaBRCA64_(SDHC) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 8 40 2.07944154167984 NA 3.80033038844005 3.09709806329151 0.703232325148543 1.28834165990178 1.10987132474749 0.617501232997236 0.545843037631924 0.633616086358965 0.117699379560184 NA NA NA 0.182848007830766 95.8977906616825 a1417 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1006 Cytarabine DNA synthesis 15 30 0.693147180559945 NA 1.71232868337392 0.956635570504004 0.755693112869913 1.45323527007992 1.51782982812249 0.504769594698201 0.520007412721515 0.497877363369966 0.117763503108795 NA NA NA 0.115957943188042 95.8977906616825 a1418 gain_cnaBRCA31 281 CH5424802 ALK 16 32 1.63315443905142 NA 3.9149342958549 3.40539229114352 0.509542004711374 0.909247711793093 1.10419147126472 0.487773731516154 0.560399545803118 0.461461637742733 0.117995383225161 NA NA NA 0.0976740311288419 95.8977906616825 a1419 loss_cnaBRCA22_(SYNCRIP,ZNF292) 254 AC220 FLT3 18 30 0.0237165266173161 NA 2.48086576316821 2.06949957762146 0.411366185546747 0.798399996550963 0.903880763009435 0.474801556779061 0.51523821057593 0.455111119056367 0.118114381615942 NA NA NA 0.108208854512422 95.8977906616825 a1420 gain_cnaBRCA30_(CRNKL1,FOXA2) 1008 Methotrexate Dihydrofolate reductase (DHFR) 5 40 -1.6094379124341 NA 1.40009871845895 0.592968993947226 0.807129724511725 1.31758906091161 1.0382815326253 0.756198689408504 0.612580772303384 0.777370779648652 0.118214650671147 NA NA NA 0.24831918898158 95.8977906616825 a1421 gain_cnaBRCA30_(CRNKL1,FOXA2) 286 KIN001-236 TIE2 5 44 2.32630161961136 NA 5.04746960703974 4.48244880730326 0.565020799736478 0.893936992207438 0.738223528274577 0.750627944092621 0.632058863948842 0.76537901881437 0.118423271799577 NA NA NA 0.235697564961104 95.8977906616825 a1422 gain_cnaBRCA31 1018 ABT-888 PARP1, PARP2 14 31 1.6094379124341 NA 4.63306975408082 4.29920813173728 0.333861622343543 0.623717849275884 0.662247316076745 0.512970767687825 0.535276684371219 0.504134353192083 0.11847281653254 NA NA NA 0.114807596702576 95.8977906616825 a1423 PIK3CA_mut 71 Pyrimethamine Dihydrofolate reductase (DHFR) 4 10 2.99573227355399 NA 5.23042834084222 4.30520764327499 0.925220697567231 0.335548951557249 1.05636412256828 0.994759099654769 2.75733449105824 0.87585395774119 0.11849474117236 NA NA NA 0.0294440255264474 95.8977906616825 a1424 gain_cnaBRCA31 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 14 31 2.30258509299405 NA 3.62755786287095 2.9733291593433 0.654228703527656 0.89769249850434 1.40844297217182 0.512806857748395 0.728789317742631 0.464504929524293 0.118587221315112 NA NA NA 0.0683321974172778 95.8977906616825 a1425 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 300 CX-5461 RNA Pol I 6 43 2.32630161961136 NA 2.89338377592274 4.05454876075409 -1.16116498483135 1.73226997060483 1.66941923644141 0.692729303341787 0.67031409915045 0.69555026052445 0.118640304652386 NA NA NA 0.17049910822818 95.8977906616825 a1426 gain_cnaBRCA19 134 Etoposide TOP2 4 43 2.77258872223978 NA 0.866778074769719 2.62689924316338 -1.76012116839366 2.5105237758314 2.08618363537541 0.831374980876386 0.701097191485777 0.843703851639566 0.118741540461938 NA NA NA 0.257293375495028 95.8977906616825 a1427 BRCA1_mut 192 LFM-A13 BTK 4 44 2.77258872223978 NA 5.42005001368248 4.73869013431469 0.681359879367791 0.458803931957511 0.840342338199174 0.830033021597348 1.48507855296866 0.810812270660934 0.118822191105573 NA NA NA 0.047556136551921 95.8977906616825 a1428 gain_cnaBRCA15 86 A-443654 AKT1, AKT2, AKT3 6 6 0.0237165266173161 NA -1.83685641371356 -0.713402793637335 -1.12345362007622 1.06061899146147 1.21540294253348 0.984933114969041 1.0592433561162 0.924346634980502 0.118827369358667 NA NA NA 0.119385265360101 95.8977906616825 a1429 gain_cnaBRCA31 260 NG-25 MAP3K7 (TAK1) 16 33 2.32630161961136 NA 3.61919734811489 3.00914149270462 0.610055855410271 1.48951474313102 1.13882183388267 0.483640442881537 0.409566845997046 0.535690340016019 0.119082003232749 NA NA NA 0.161182590120487 95.8977906616825 a1430 gain_cnaBRCA16 1248 FK866 NAMPT 16 28 0 NA 0.192186350009371 -1.13235856772353 1.3245449177329 2.61203492156865 2.68259036360763 0.498397582216922 0.507093112268747 0.493755936687855 0.119259364704797 NA NA NA 0.118917655184097 95.8977906616825 a1431 gain_cnaBRCA47_(EGFR) 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 3 23 2.30258509299405 NA 1.65049431245215 2.82733151222391 -1.17683719977176 1.08873180274125 1.19530732137249 0.991612319072967 1.08092479415838 0.984547805179076 0.119295663685691 NA NA NA 0.191274964012502 95.8977906616825 a1432 gain_cnaBRCA10_(MDM2,NUP107) 1058 GDC0941 PI3K (class 1) 3 40 1.38629436111989 0.693147180559945 2.54786121150317 1.25586317139861 1.29199804010456 1.59216895467824 1.3439399435777 0.952026883471544 0.811470438679453 0.961351023368748 0.119427546954918 NA NA NA 0.292969905574859 95.8977906616825 a1433 gain_cnaBRCA63 1049 PD-173074 FGFR1, FGFR3 5 38 0.693147180559945 NA 3.68517480860066 2.83942046112271 0.845754347477956 1.08091599452956 1.12251667707963 0.75613280864214 0.782442254308623 0.753444794849994 0.119646526819611 NA NA NA 0.160200138736479 95.8977906616825 a1434 gain_cnaBRCA30_(CRNKL1,FOXA2) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 41 1.38629436111989 NA 3.83104432497861 2.74001959994345 1.09102472503516 1.77781246545104 1.41543542888572 0.751332114236873 0.613689433636839 0.770805013616239 0.119878661850605 NA NA NA 0.247557635842685 95.8977906616825 a1435 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 6 39 2.30258509299405 NA 2.01613121404916 1.26519983091259 0.75093138313657 1.23975589583595 1.0573149004354 0.695233818590174 0.605709063904251 0.710224912963337 0.120208364788152 NA NA NA 0.207727795630338 95.8977906616825 a1436 loss_cnaBRCA33 1259 BMN-673 PARP1 4 42 2.30258509299405 NA 4.46112275143847 3.19548235374023 1.26564039769824 0.719429502594019 1.56919857403206 0.82918706378706 1.75922782306644 0.806552095217738 0.120212032682973 NA NA NA 0.0254894651451492 95.8977906616825 a1437 gain_cnaBRCA64_(SDHC) 1375 Temozolomide DNA akylating agent 9 37 3.40119738166216 NA 6.22429222461363 5.82127467588211 0.403017548731517 0.958238678599978 0.606903467609105 0.588920180121926 0.420581591759937 0.664055439193986 0.120235788116362 NA NA NA 0.257255155059931 95.8977906616825 a1438 gain_cnaBRCA63 1375 Temozolomide DNA akylating agent 6 40 3.40119738166216 NA 6.31291498246071 5.83820757835991 0.474707404100799 1.20635673186119 0.584617161825638 0.693677583371033 0.393504998615468 0.811997038572023 0.12024847142488 NA NA NA 0.384206425935841 95.8977906616825 a1439 gain_cnaBRCA64_(SDHC) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 8 38 1.63315443905142 NA 2.73131242939402 1.76928603580751 0.962026393586508 2.12082996732445 1.43051365610593 0.616330554493699 0.453608449714693 0.672504166234445 0.12025909476807 NA NA NA 0.253619885561463 95.8977906616825 a1440 loss_cnaBRCA33 226 GSK1070916 AURKB 6 43 0.940007258491471 2.32630161961136 1.24685321133642 2.56540275542406 -1.31854954408765 2.68159658910417 1.79863346981456 0.689601321769765 0.4917031702103 0.733084069776368 0.120270399923106 NA NA NA 0.289644889138585 95.8977906616825 a1441 CDH1_mut 299 OSI-027 MTORC1/2 4 44 2.99573227355399 NA -0.206778265946353 1.40312845722833 -1.60990672317469 1.93019802038438 1.94883290986502 0.826600785551604 0.834062985337684 0.826087611218652 0.120314511491503 NA NA NA 0.194003400425358 95.8977906616825 a1442 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 333 T0901317 LXR 6 42 2.32630161961136 NA 5.18862843033804 4.67069445969994 0.517933970638092 0.45728125280837 0.778352390434576 0.690449743421898 1.13263766545693 0.665423498409139 0.12049739719259 NA NA NA 0.04233378182404 95.8977906616825 a1443 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 302 PI-103 PI3Ka, PRKDC (DNAPK) 7 41 2.32630161961136 NA 0.123412495448234 1.30002205325097 -1.17660955780274 1.65581395979156 1.84250912570613 0.646757266688636 0.710592848215181 0.638590898349993 0.120622343229078 NA NA NA 0.122762379647925 95.8977906616825 a1444 gain_cnaBRCA31 1264 SGC0946 Q8TEK3 (DOT1L) 14 32 -0.693147180559945 NA 2.16058550807148 1.85889473124282 0.301690776828656 0.50941514836409 0.627526882472999 0.50697922705958 0.592229692810453 0.480761518358756 0.120775660511139 NA NA NA 0.0959990629278268 95.8977906616825 a1445 BRCA2_mut 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 6 42 2.07944154167984 NA 2.52660606567072 3.31254593440849 -0.78593986873777 1.12554836979214 1.14102228275004 0.689813940336306 0.698272850666484 0.688803260566947 0.120830638946551 NA NA NA 0.157125783412711 95.8977906616825 a1446 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1018 ABT-888 PARP1, PARP2 6 39 1.6094379124341 NA 4.79465154318503 4.34283383030453 0.451817712880502 0.858337720744891 0.618661940930747 0.693950866350006 0.526386877752968 0.730314381713484 0.12087492376397 NA NA NA 0.262323119980423 95.8977906616825 a1447 gain_cnaBRCA47_(EGFR) 1072 BMS-708163 g-secretase 7 39 1.6094379124341 NA 3.16891083347179 3.77674650091383 -0.60783566744204 0.757177299283385 0.961488443908832 0.64921890409824 0.802765307435013 0.632181979193579 0.120906100263652 NA NA NA 0.0914093804908991 95.8977906616825 a1448 gain_cnaBRCA16 201 Epothilone B Microtubules 16 32 -3.44201937618241 NA -3.66497471757358 -4.52114952837282 0.856174810799237 1.81082547330864 1.75121377835546 0.483476156189924 0.472809126787289 0.488903651502365 0.121182752541325 NA NA NA 0.129261096247379 95.8977906616825 a1449 loss_cnaBRCA36_(FAT1,IRF2) 1164 XMD8-92 MAP2K5 (ERK5) 3 23 2.30258509299405 NA 2.78917936597712 4.02735545902089 -1.23817609304377 0.887028033650229 1.28363581738875 0.986295819824139 1.39587030631775 0.964585185510443 0.121190244896848 NA NA NA 0.115359897641196 95.8977906616825 a1450 ASH1L_mut 1013 Nilotinib ABL 3 37 0.693147180559945 NA 2.37928229518682 3.26968779488276 -0.890405499695942 0.255360558275065 0.959803800467776 0.951247781094974 3.48685601923235 0.927695326130182 0.121340696900656 NA NA NA 0.0028638918737903 95.8977906616825 a1451 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 303 PIK-93 PI4K, PI3K 15 34 2.99573227355399 NA 2.31791309938081 3.00047459685293 -0.682561497472117 1.08245109153889 1.50948759316015 0.4889363759352 0.630570288863342 0.45218092587509 0.121413304063833 NA NA NA 0.0814023825334435 95.8977906616825 a1452 PTEN_mut 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 6 37 1.6094379124341 NA 2.03124428588828 3.00364241493107 -0.972398129042796 1.83742580298339 1.32478216835407 0.695859838354923 0.52921763015624 0.734006051916384 0.121536026786895 NA NA NA 0.260541120185865 95.8977906616825 a1453 ARID1A_mut 178 BAY 61-3606 SYK 5 43 2.07944154167984 NA 2.04312889481067 3.21815095268939 -1.17502205787871 1.10995063391211 1.61407342797817 0.745265685798103 1.05862551178268 0.727985503949826 0.121583401637599 NA NA NA 0.0769110548748396 95.8977906616825 a1454 ASH1L_mut 154 CHIR-99021 GSK3B 3 44 0.940007258491471 NA 2.49207459282144 3.32884792287681 -0.83677333005537 1.00373314881837 0.883048113624494 0.941506567360789 0.833661148922352 0.947596531995083 0.12160840731549 NA NA NA 0.283196249978051 95.8977906616825 a1455 loss_cnaBRCA17 1170 CCT018159 HSP90 9 34 2.30258509299405 NA 3.88922933608836 3.19819287106594 0.691036465022425 1.20973241741629 1.15562256689122 0.592463705591455 0.571230840038428 0.597977648430148 0.121682515561908 NA NA NA 0.149660309342165 95.8977906616825 a1456 gain_cnaBRCA30_(CRNKL1,FOXA2) 344 THZ-2-49 CDK9 5 44 2.99573227355399 NA 2.75169574402491 1.67545445575598 1.07624128826893 1.58414226861317 1.43361683984423 0.743755073125512 0.679384238141136 0.750717526717856 0.121744623971308 NA NA NA 0.208597385992859 95.8977906616825 a1457 gain_cnaBRCA31 32 VX-680 AURKA, AURKB, AURKC, FLT3, ABL1, JAK2 3 9 0.693147180559945 NA 2.85742450874899 0.635713486016705 2.22171102273229 0.677928312745335 2.17760058983521 1.12710825850756 3.27720642575799 1.02025643871653 0.121780215910281 NA NA NA 0.0226158404726839 95.8977906616825 a1458 loss_cnaBRCA33 222 BX-912 PDPK1 (PDK1) 6 43 2.32630161961136 NA 2.98948550163314 4.00856616753074 -1.0190806658976 2.01811883242767 1.40731471038438 0.686577917666257 0.504965639050955 0.724131324982213 0.121863150557188 NA NA NA 0.278731281298066 95.8977906616825 a1459 gain_cnaBRCA47_(EGFR) 294 MPS-1-IN-1 MPS1 7 42 2.99573227355399 NA 4.12208380113174 4.86225668659126 -0.740172885459519 1.13490561568916 1.15343971015576 0.643018973646501 0.652188935561887 0.641709210236544 0.121948758691097 NA NA NA 0.148693488691069 95.8977906616825 a1460 gain_cnaBRCA64_(SDHC) 1038 NU-7441 PRKDC (DNAPK) 7 36 0.693147180559945 NA 3.39813282119656 2.7946184979322 0.603514323264357 1.09964420890828 0.891774143919652 0.65236592556565 0.5488269008969 0.676756920324809 0.121958499445116 NA NA NA 0.210550757891987 95.8977906616825 a1461 loss_cnaBRCA18 269 NSC-207895 MDM4 16 33 2.99573227355399 NA 4.2270455726247 4.78668025494725 -0.559634682322541 1.09453672945828 1.19856835929492 0.479806689996808 0.511298220754565 0.466919285815083 0.121960645922651 NA NA NA 0.113569162586268 95.8977906616825 a1462 gain_cnaBRCA10_(MDM2,NUP107) 330 XMD13-2 RIPK 5 43 2.32630161961136 NA 4.51638631328079 3.62853693398237 0.887849379298416 0.544718221139482 1.23827633546584 0.743550474158472 1.6299241421393 0.717004237155517 0.122421205009728 NA NA NA 0.0165136605598211 95.8977906616825 a1463 gain_cnaBRCA30_(CRNKL1,FOXA2) 184 BMS-754807 IGF1R 5 43 0.940007258491471 NA 2.72400190076946 1.49929535629737 1.22470654447209 1.52513659155371 1.65878047299789 0.74333225795063 0.803014334096095 0.738317435253321 0.122528127076243 NA NA NA 0.151198480473723 95.8977906616825 a1464 gain_cnaBRCA10_(MDM2,NUP107) 221 TAK-715 p38a 5 44 2.99573227355399 2.32630161961136 5.14068970599156 4.40731896479381 0.733370741197751 0.324482916516988 1.02865813286953 0.741936098015962 2.26012126946399 0.712939233904614 0.122636123675135 NA NA NA 0.00318177045504062 95.8977906616825 a1465 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 6 43 1.63315443905142 NA 2.9863399430256 3.65902670589141 -0.672686762865808 1.01669530469201 0.97768691056972 0.685079575938843 0.661640473563108 0.688039039485369 0.122658771957425 NA NA NA 0.175262156597988 95.8977906616825 a1466 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 192 LFM-A13 BTK 7 41 2.77258872223978 NA 5.24652535324526 4.71846069492341 0.528064658321855 1.1725891724008 0.754688626624664 0.642926328790231 0.450340725252201 0.69971196026051 0.122779973718054 NA NA NA 0.288013516845389 95.8977906616825 a1467 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 294 MPS-1-IN-1 MPS1 15 34 2.99573227355399 NA 5.14560293123066 4.58486245518516 0.560740476045503 1.00121671718722 1.20925500927591 0.487081882368174 0.560059042582536 0.463707383260102 0.122796380244112 NA NA NA 0.10032370427605 95.8977906616825 a1468 gain_cnaBRCA9_(KRAS) 274 PXD101, Belinostat HDAC 4 44 2.99573227355399 NA -0.432941774336558 0.771907447811542 -1.2048492221481 1.54073081869363 1.46298615680778 0.820640260529936 0.781998521435224 0.823554766079992 0.122942101324157 NA NA NA 0.216718301029804 95.8977906616825 a1469 ASH1L_mut 1239 YK 4-279 RNA helicase A 3 39 2.30258509299405 NA 0.903103926447836 2.0989720304341 -1.19586810398626 0.532416916572323 1.29432856069447 0.943738535243586 2.24611214776046 0.923929317718696 0.123100620979368 NA NA NA 0.0300772502926017 95.8977906616825 a1470 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1264 SGC0946 Q8TEK3 (DOT1L) 14 32 -0.693147180559945 NA 2.15924831490087 1.85947975325497 0.299768561645897 0.573340585776927 0.604257639362901 0.503567101474886 0.522845528613126 0.496093954164912 0.123228171413522 NA NA NA 0.12055199366394 95.8977906616825 a1471 gain_cnaBRCA47_(EGFR) 346 THZ-2-102-1 CDK7 7 41 0.916290731874155 2.99573227355399 -2.70508759427154 -1.10126715845565 -1.60382043581589 2.04276985897885 2.55911362106896 0.642086805949005 0.785120471974073 0.626709350695403 0.123256938719838 NA NA NA 0.096285607363667 95.8977906616825 a1472 gain_cnaBRCA31 127 GSK269962A ROCK1, ROCK2 4 10 0.916290731874155 NA 3.1879223894723 2.18013579390142 1.00778659557088 0.364611164428853 1.16809909355322 0.980433207945749 2.76400366716563 0.862757792667494 0.123364658552933 NA NA NA 0.0310706944615867 95.8977906616825 a1473 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 235 QL-XII-47 BTK, BMX 6 43 2.32630161961136 NA 0.821796845849636 1.83174182723518 -1.00994498138554 1.58832579979011 1.4633609362152 0.68370831782401 0.635855050342319 0.690154394853289 0.123390577506073 NA NA NA 0.189354524149014 95.8977906616825 a1474 BRCA2_mut 136 Mitomycin C DNA crosslinker 6 42 2.77258872223978 NA -1.0040958349747 -0.0100494929657278 -0.994046342008967 1.49618529615592 1.44593780585827 0.684848411273181 0.664387188246621 0.68747517215578 0.123458899988257 NA NA NA 0.174095289948536 95.8977906616825 a1475 loss_cnaBRCA57 341 EX-527 SIRT1 5 44 2.99573227355399 NA 6.06902109225517 5.59320007362594 0.475821018629224 0.155584902129345 0.670366128856807 0.740220158592505 3.05827244235853 0.709792750777331 0.123481942505464 NA NA NA 0.000600246654674416 95.8977906616825 a1476 TP53_mut 333 T0901317 LXR 37 11 2.32630161961136 NA 4.82806340187645 4.42387200181793 0.404191400058518 0.787239784698165 0.599740133769 0.538581076049085 0.513428574006189 0.673944225673913 0.123666457220138 NA NA NA 0.0832035442138461 95.8977906616825 a1477 loss_cnaBRCA57 1047 Nutlin-3a MDM2 5 38 2.07944154167984 1.38629436111989 4.85744318695095 4.1213526445201 0.736090542430852 0.804107202695239 1.00203364682265 0.747697015833613 0.915413442341512 0.734596632323601 0.123707579903215 NA NA NA 0.113314092603098 95.8977906616825 a1478 loss_cnaBRCA33 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 5 40 2.30258509299405 NA 0.649995976452596 1.45474002019058 -0.80474404373798 1.12186736483578 1.07638258884779 0.744654525074606 0.717325478004058 0.747637551996655 0.123775746106788 NA NA NA 0.189617880033436 95.8977906616825 a1479 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 54 CGP-082996 CDK4 3 9 1.63315443905142 NA 3.59356563551106 2.54759512456047 1.04597051095059 0.605025829018556 0.999242332969986 1.12011170853326 1.72880307051901 1.04676360922552 0.123844908235984 NA NA NA 0.073043313931291 95.8977906616825 a1480 loss_cnaBRCA57 1230 IOX2 EGLN1 5 42 -2.30258509299405 NA -0.175862099224611 0.300096618444269 -0.475958717668881 1.28330005458392 0.53956500713812 0.741840786806535 0.370886540500616 0.882115614193348 0.123865599312035 NA NA NA 0.45612839759875 95.8977906616825 a1481 gain_cnaBRCA63 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 5 38 1.6094379124341 NA 3.79072968721232 2.74654175346625 1.04418793374607 1.98759075436996 1.31851994011307 0.746935061873387 0.525353587729412 0.791939432980075 0.124079819876798 NA NA NA 0.310804745113893 95.8977906616825 a1482 gain_cnaBRCA16 1020 Lenalidomide TNFA 15 30 1.6094379124341 NA 4.48493601937937 4.13962185563653 0.345314163742835 0.771546335278194 0.657094723309874 0.495837448568211 0.44756114824695 0.525516567844954 0.124217225308395 NA NA NA 0.150347221116752 95.8977906616825 a1483 PIK3CA_mut 163 JQ1 BRD4 16 31 0.940007258491471 NA 0.770877611794721 0.0810982324756975 0.689779379319023 1.4404108868967 1.42638812148647 0.481999968498633 0.478876816048731 0.483584635155396 0.124399174565935 NA NA NA 0.128998351953408 95.8977906616825 a1484 loss_cnaBRCA60 271 VNLG/124 HDAC, RAR 3 46 1.63315443905142 NA 3.45258048822486 4.19701790676584 -0.744437418540984 0.951945876906419 0.79121279893364 0.93204771560168 0.782016537494984 0.940881415902653 0.124490238768231 NA NA NA 0.306771844719169 95.8977906616825 a1485 gain_cnaBRCA48 303 PIK-93 PI4K, PI3K 5 44 2.99573227355399 NA 3.71724813862761 2.68633163842213 1.03091650020548 1.48350794910073 1.38824148648766 0.738160397938639 0.694918083068176 0.742606030895797 0.124503437914189 NA NA NA 0.200447717588011 95.8977906616825 a1486 gain_cnaBRCA8_(CHD4,WNK1) 1017 Olaparib PARP1, PARP2 3 42 1.6094379124341 NA 3.31219171771236 4.12851998211104 -0.816328264398678 0.773942923628332 0.876623482640509 0.936032011970561 1.05476546070302 0.931218796397954 0.124613313641087 NA NA NA 0.201904621290867 95.8977906616825 a1487 ASH1L_mut 288 KIN001-055 JAK3, MNK1 3 46 2.32630161961136 NA 3.60434537618902 4.38691970354497 -0.782574327355948 1.27022643634719 0.815663259377423 0.93160035458759 0.616090411097417 0.959433097370684 0.124666621410967 NA NA NA 0.397866222540063 95.8977906616825 a1488 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 186 Bexarotene Retinioic acid X family agonist 6 41 2.07944154167984 NA 2.93685469538566 3.70209581835244 -0.765241122966789 1.84294462677846 0.991950799280466 0.683900221136409 0.415227409357633 0.77145068437051 0.12467591334939 NA NA NA 0.361440447020007 95.8977906616825 a1489 loss_cnaBRCA34 326 GSK690693 AKT 5 43 2.32630161961136 NA 4.19374958836704 2.7937443740143 1.40000521435274 0.41878154040843 1.97864521324744 0.738910016130494 3.34304423491862 0.707557476691332 0.12471122852042 NA NA NA 0.000420203271916841 95.8977906616825 a1490 CDH1_mut 157 JNK-9L JNK 4 43 1.63315443905142 NA 0.831053888026339 -0.0162682221926203 0.84732211021896 1.50730570503409 0.993971592437336 0.817770708469474 0.562143503729255 0.852461093119599 0.124730461524187 NA NA NA 0.345286860664484 95.8977906616825 a1491 loss_cnaBRCA60 1377 Afatinib (rescreen) ERBB2, EGFR 3 44 2.30258509299405 NA 4.53964082923417 2.71839008232783 1.82125074690634 0.0781234206077413 1.99596569997309 0.933411668822941 23.312480850664 0.912465954164892 0.124760547788338 NA NA NA 3.41389307811975e-07 95.8977906616825 a1492 gain_cnaBRCA10_(MDM2,NUP107) 1053 MK-2206 AKT1, AKT2 3 39 1.38629436111989 0.693147180559945 2.79848627880457 1.28583234315565 1.51265393564892 0.475533834904937 1.64861063496444 0.939314170613756 3.18095963865813 0.917532559579506 0.124815383003183 NA NA NA 0.00524633671870864 95.8977906616825 a1493 gain_cnaBRCA61_(NOTCH2) 207 AS601245 JNK 3 45 2.07944154167984 NA 3.36748059733889 2.1927820542046 1.17469854313429 1.51458425775819 1.24735309010455 0.932188881256717 0.775591412043996 0.941753022823573 0.124829665752473 NA NA NA 0.309824967418182 95.8977906616825 a1494 MLL3_mut 178 BAY 61-3606 SYK 3 45 2.07944154167984 NA 1.7173622051211 3.18764552942964 -1.47028332430854 0.419809363807437 1.61033365107753 0.932111696290807 3.50226424435579 0.913030242723124 0.124860100640261 NA NA NA 0.00298201107702154 95.8977906616825 a1495 gain_cnaBRCA31 1001 AICAR AAPK1 (AMPK) agonist 14 31 7.60090245954208 NA 8.20839186212768 7.52626652376452 0.682125338363158 1.63138550805864 1.21420873775954 0.503801498300372 0.418126393175388 0.561785891626686 0.125011722466411 NA NA NA 0.177231863554428 95.8977906616825 a1496 gain_cnaBRCA27_(CLTC,PPM1D) 186 Bexarotene Retinioic acid X family agonist 8 39 2.07944154167984 NA 3.04117112490874 3.71994071091011 -0.678769586001373 1.69147632344034 0.977642277063759 0.606584747622129 0.40128825724312 0.69429238273122 0.125091719319101 NA NA NA 0.304199093228459 95.8977906616825 a1497 gain_cnaBRCA48 292 Masitinib KIT 5 43 2.99573227355399 NA 4.71757565580164 3.92808920994723 0.789486445854408 0.935569219000917 1.08170121754673 0.737984842397807 0.843856798428544 0.729856297698305 0.125171893260066 NA NA NA 0.135929986163629 95.8977906616825 a1498 loss_cnaBRCA7_(FAS,PTEN) 206 Ruxolitinib JAK1, JAK2, TYK2 4 45 1.65632149833295 0.0237165266173161 3.89024774897885 4.41292824818442 -0.522680499205575 1.45086046717601 0.544552842458384 0.81433445939345 0.360255524931997 0.959834305236447 0.125285188586276 NA NA NA 0.524502253932568 95.8977906616825 a1499 CDH1_mut 1241 CHIR-99021 GSK3B 5 41 2.30258509299405 NA 4.86424775198498 4.15432115840182 0.709926593583158 0.654450800384053 0.984461725127326 0.740151293798819 1.08476694224616 0.721131736727844 0.125336129941023 NA NA NA 0.0721168867632574 95.8977906616825 a1500 gain_cnaBRCA62 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 9 39 2.07944154167984 NA 3.74884378291604 3.09094798956247 0.657895793353572 1.16357567663305 1.1350877649071 0.577054335973071 0.56540868511215 0.579599052772291 0.125508001363296 NA NA NA 0.150966334135764 95.8977906616825 a1501 BRCA1_mut 1042 BIRB 0796 p38, JNK2 4 39 2.30258509299405 NA 3.69257103214388 4.43572627486147 -0.743155242717587 0.335383725138984 0.93538673204162 0.821099279983612 2.21583573385865 0.794489826785912 0.125515206559573 NA NA NA 0.00884179738736413 95.8977906616825 a1502 loss_cnaBRCA34 1194 SB-505124 TGFR1 (ALK5) 5 42 2.30258509299405 NA 3.79442962287979 4.45978116857424 -0.665351545694444 0.740749372902063 0.915260584779073 0.738362247317276 0.898214119423105 0.726953128714755 0.125591396864452 NA NA NA 0.117969243542152 95.8977906616825 a1503 loss_cnaBRCA57 1375 Temozolomide DNA akylating agent 5 41 3.40119738166216 NA 6.35142609617106 5.84508933044648 0.506336765724588 0.180045504708432 0.716053487537019 0.739301858041041 2.81227107860624 0.707121429526466 0.125758807179364 NA NA NA 0.00113683981406831 95.8977906616825 a1504 gain_cnaBRCA14_(RAD21) 341 EX-527 SIRT1 21 28 2.99573227355399 NA 5.80708350219337 5.51775554124131 0.289327960952066 0.58345793217652 0.683784476604679 0.449959786995782 0.495884870178664 0.423127419313055 0.125774779122966 NA NA NA 0.117562423909319 95.8977906616825 a1505 PIK3CA_mut 1067 CCT007093 PPM1D 16 30 1.88706964903238 NA 3.78107199312633 4.24807048032222 -0.466998487195895 1.06372022343625 0.91309619494436 0.482893163030475 0.439023793011381 0.511445004131631 0.125951464878002 NA NA NA 0.148383580255027 95.8977906616825 a1506 gain_cnaBRCA47_(EGFR) 1005 Cisplatin DNA crosslinker 7 38 1.79175946922805 2.30258509299405 3.04148788978492 3.78587748928638 -0.744389599501453 0.92460915931841 1.19364040468798 0.641796276996489 0.805085686205176 0.623629693312903 0.12599945206813 NA NA NA 0.0917546591829942 95.8977906616825 a1507 loss_cnaBRCA18 1054 PD-0332991 CDK4, CDK6 12 30 1.38629436111989 0.693147180559945 3.43004368802475 2.66404915843211 0.765994529592638 1.42779697007494 1.43796215946689 0.53372941380918 0.536487011561898 0.532694497243672 0.126024739464713 NA NA NA 0.132340806304279 95.8977906616825 a1508 loss_cnaBRCA7_(FAS,PTEN) 1377 Afatinib (rescreen) ERBB2, EGFR 4 43 2.30258509299405 NA 4.28949542966159 2.69930475329024 1.59019067637134 0.880402909152406 2.00627225396017 0.814844014216464 1.80620788486748 0.792609613791187 0.126050172841079 NA NA NA 0.0228455917632627 95.8977906616825 a1509 gain_cnaBRCA16 204 Tipifarnib Farnesyl-transferase (FNTA) 16 32 2.77258872223978 NA 2.09277430912931 1.38357763668733 0.709196672441985 1.78029469019852 1.32163501011576 0.476986862573509 0.398359146014699 0.536605543144523 0.126127093784134 NA NA NA 0.171364020911859 95.8977906616825 a1510 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1149 TW 37 BCL2, BCL2L1 8 35 1.6094379124341 NA 0.466126054870707 -0.281472310234462 0.747598365105168 1.29630796460912 1.20594526650708 0.611859619549037 0.576713547641123 0.619927276857702 0.126130927932451 NA NA NA 0.167075303444452 95.8977906616825 a1511 ASH1L_mut 1017 Olaparib PARP1, PARP2 3 42 1.6094379124341 NA 3.31522409090796 4.12830338402564 -0.813079293117674 1.15879153500643 0.855889503257737 0.932095419974524 0.701661402033943 0.949981615644174 0.126162710641573 NA NA NA 0.347695648002805 95.8977906616825 a1512 gain_cnaBRCA15 1133 JNJ-26854165 MDM2 21 22 2.30258509299405 NA 3.17706649539087 2.77003100787454 0.407035487516326 0.851291507911608 0.857993622496183 0.476214800350568 0.478138785285039 0.474403861338883 0.126221589858307 NA NA NA 0.126164933511748 95.8977906616825 a1513 loss_cnaBRCA17 175 PAC-1 CASP3 agonist 11 37 0.940007258491471 NA 1.90638492318856 2.54854303435284 -0.642158111164277 1.30975302188934 1.16857208269292 0.534830213346744 0.490289467122552 0.549523748406221 0.126236182546773 NA NA NA 0.164225911350189 95.8977906616825 a1514 gain_cnaBRCA10_(MDM2,NUP107) 1042 BIRB 0796 p38, JNK2 3 40 2.30258509299405 NA 5.1533265642318 4.30759072888694 0.845735835344865 0.557474858445643 0.919468167954758 0.934334199232665 1.51708336713687 0.919809803993648 0.12624788569302 NA NA NA 0.0995186185625182 95.8977906616825 a1515 BRCA1_mut 283 GSK2126458 PI3K, MTOR 4 44 -2.05572501506252 0.0237165266173161 -1.85904661211227 -3.16411347599752 1.30506686388525 2.6808216763774 1.50109033998429 0.813283748033065 0.486815992046435 0.869412605705604 0.126248696669809 NA NA NA 0.40433151836084 95.8977906616825 a1516 POLR2B_mut 1017 Olaparib PARP1, PARP2 3 42 1.6094379124341 NA 3.31544998613174 4.12828724865251 -0.812837262520772 0.986105759076843 0.866395798706207 0.931802272373937 0.824290148433694 0.938182368537089 0.126278708794418 NA NA NA 0.287213184802275 95.8977906616825 a1517 loss_cnaBRCA18 1175 AG-014699 PARP1, PARP2 14 29 1.6094379124341 NA 4.20606689919666 3.69526211375947 0.510804785437187 0.722088943811666 1.11313990797751 0.507885925975461 0.707398707340427 0.458886418298739 0.126301890938849 NA NA NA 0.0789664290583215 95.8977906616825 a1518 gain_cnaBRCA10_(MDM2,NUP107) 193 GW-2580 CSF1R (cFMS) 5 43 2.99573227355399 NA 5.94606525351638 5.40726370636643 0.538801547149947 0.425772749475519 0.75511178579806 0.735689227475312 1.26546743025161 0.713538786287782 0.126320849384654 NA NA NA 0.0443033416106211 95.8977906616825 a1519 BRCA1_mut 1022 AZD7762 CHEK1, CHEK2 4 41 0.693147180559945 NA -0.279237608319145 1.0202617386855 -1.29949934700464 1.13649774817256 1.6205289343361 0.816502631137713 1.14342448024572 0.801898268812472 0.126388737745996 NA NA NA 0.100161130111409 95.8977906616825 a1520 gain_cnaBRCA30_(CRNKL1,FOXA2) 156 AZD6482 PI3Kbeta 5 42 1.63315443905142 NA 2.99791685328108 1.94085658155127 1.05706027172981 1.22854741045362 1.4535881282071 0.736620028870916 0.860414716384054 0.727207557090895 0.126463008917163 NA NA NA 0.130333590636416 95.8977906616825 a1521 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 206 Ruxolitinib JAK1, JAK2, TYK2 7 42 1.65632149833295 0.0237165266173161 4.71959226543151 4.31203848348081 0.407553781950703 0.827814445968762 0.61003725341206 0.634853124298036 0.492325042085679 0.668080153582709 0.12663898682479 NA NA NA 0.25169819470794 95.8977906616825 a1522 gain_cnaBRCA14_(RAD21) 86 A-443654 AKT1, AKT2, AKT3 6 6 0.0237165266173161 NA -1.82656505748415 -0.723694149866742 -1.10287090761741 1.07672881038045 1.21254538274681 0.961820225072609 1.024279184308 0.909550210087026 0.126698018512416 NA NA NA 0.127124503098666 95.8977906616825 a1523 gain_cnaBRCA48 275 I-BET BRD2, BRD3, BRD4 5 44 2.99573227355399 NA 4.91870017310793 3.93896843276631 0.97973174034162 1.44124653592661 1.32520500441829 0.733621258808011 0.679780811900947 0.739305795763788 0.126778543917182 NA NA NA 0.208580124472939 95.8977906616825 a1524 loss_cnaBRCA29_(MAP2K4) 200 LAQ824 HDAC 7 41 0.0237165266173161 NA -3.43690994182671 -2.5560016117486 -0.880908330078113 0.729889469538861 1.45868366532206 0.635788508320361 1.20690647946279 0.603906351336032 0.126883063898475 NA NA NA 0.0256496896685092 95.8977906616825 a1525 gain_cnaBRCA63 38 AZD-0530 SRC, ABL1 3 11 0.693147180559945 NA 2.07545730068327 2.72585162523272 -0.650394324549456 0.721158168296126 0.583714884398636 1.068355499588 0.901874724772426 1.11423289337485 0.12688582903811 NA NA NA 0.253212680095685 95.8977906616825 a1526 MLL3_mut 204 Tipifarnib Farnesyl-transferase (FNTA) 3 45 2.77258872223978 NA 0.328358629909172 1.7060843873408 -1.37772575743163 0.868218525516246 1.50913011607447 0.926501435678509 1.58684215660156 0.912927084786665 0.127088337132857 NA NA NA 0.0905886220898578 95.8977906616825 a1527 gain_cnaBRCA13_(FGFR1,WHSC1L1) 37 Crizotinib MET, ALK 4 10 0.693147180559945 NA 2.14849634348107 2.85381093777491 -0.705314594293843 0.814899427110357 0.696149423349516 0.969296720800161 0.865523487720315 1.01316552256874 0.127271286053784 NA NA NA 0.18980994400173 95.8977906616825 a1528 gain_cnaBRCA15 229 LY317615 PRKCB (PKCbeta) 22 27 2.99573227355399 2.32630161961136 2.96900384532175 3.67601799745177 -0.707014152130021 1.55887626808606 1.60708292510078 0.445861794676473 0.453540904178412 0.439936322567602 0.127281983855938 NA NA NA 0.126321893065912 95.8977906616825 a1529 PIK3CA_mut 303 PIK-93 PI4K, PI3K 17 32 2.99573227355399 NA 2.36690614350403 3.01710713575448 -0.650200992250443 1.55945671419233 1.30558491550925 0.465360744399865 0.416940711680601 0.49801509233647 0.127713184594798 NA NA NA 0.153348386906931 95.8977906616825 a1530 POLR2B_mut 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 39 -1.38629436111989 0.693147180559945 1.13512329311733 -0.412804127423166 1.5479274205405 0.929444893853227 1.6908841961797 0.931856216968476 1.66543216362533 0.91545442558267 0.127749586536722 NA NA NA 0.0784925561913322 95.8977906616825 a1531 ARID1A_mut 229 LY317615 PRKCB (PKCbeta) 5 44 2.99573227355399 2.32630161961136 4.4004486040687 3.24018926154393 1.16025934252477 1.5274605065767 1.5911494049279 0.731642310550868 0.759600223723692 0.729195724129591 0.127780832072858 NA NA NA 0.169465018484972 95.8977906616825 a1532 BRCA1_mut 1218 JQ1 BRD2, BRD3, BRD4 4 42 0 NA 1.94711927728774 2.5066354524568 -0.55951617516906 0.909080546278822 0.670094761851136 0.812037558422062 0.61547480854073 0.834980672917659 0.127860233795073 NA NA NA 0.30865993201418 95.8977906616825 a1533 loss_cnaBRCA57 305 TPCA-1 IKK 5 44 2.99573227355399 NA 5.06960204504163 4.07704503845593 0.992557006585701 0.880757819692339 1.39304372522629 0.731437408931989 1.12693521918706 0.71250958502718 0.127884972043989 NA NA NA 0.0641552937360092 95.8977906616825 a1534 ASH1L_mut 228 KIN001-102 AKT1 3 46 2.32630161961136 NA 3.14150151475892 1.86558634040758 1.27591517435133 0.68300967996119 1.40537720595562 0.923004779893353 1.86807773269602 0.907880936836277 0.128094848468732 NA NA NA 0.0586002931976165 95.8977906616825 a1535 gain_cnaBRCA10_(MDM2,NUP107) 1067 CCT007093 PPM1D 3 43 1.88706964903238 NA 4.92303730912461 4.0272128923794 0.89582441674521 0.493236345320539 0.984278140630429 0.926030997547038 1.81621736768616 0.910133406164477 0.128125651159735 NA NA NA 0.0627567640181197 95.8977906616825 a1536 loss_cnaBRCA7_(FAS,PTEN) 1502 Bicalutamide ANDR (androgen receptor) 4 41 2.30258509299405 NA 4.98208752075266 4.51695831462663 0.465129206126029 0.382957068943884 0.58417870847991 0.812538089213138 1.21457271283374 0.796210473566113 0.128190676520159 NA NA NA 0.0858425532653224 95.8977906616825 a1537 gain_cnaBRCA30_(CRNKL1,FOXA2) 302 PI-103 PI3Ka, PRKDC (DNAPK) 5 43 2.32630161961136 NA -0.0655981586052223 1.26727401033613 -1.33287216894135 1.09320941573136 1.87580871392776 0.731882347376429 1.21922858489986 0.710558682793645 0.128244875422953 NA NA NA 0.050219881547067 95.8977906616825 a1538 gain_cnaBRCA61_(NOTCH2) 286 KIN001-236 TIE2 3 46 2.32630161961136 NA 5.19276426650243 4.49753919037033 0.695225076132107 0.351020061756119 0.766754596684976 0.922355653837504 1.9805850202805 0.906711324767894 0.128356786656143 NA NA NA 0.0489074037542466 95.8977906616825 a1539 gain_cnaBRCA63 163 JQ1 BRD4 6 41 0.940007258491471 NA 1.16135238311566 0.192194456018736 0.969157927096926 1.95236688130391 1.35282630935951 0.676837008867636 0.49640154029332 0.716394943232415 0.128514114854679 NA NA NA 0.286423079516905 95.8977906616825 a1540 loss_cnaBRCA34 271 VNLG/124 HDAC, RAR 5 44 1.63315443905142 NA 3.6275246689408 4.21097595070908 -0.583451281768282 0.763504866108195 0.802377505826319 0.730096387284927 0.764174935442523 0.727153088828707 0.128568220728734 NA NA NA 0.167482425616417 95.8977906616825 a1541 PIK3CA_mut 228 KIN001-102 AKT1 17 32 2.32630161961136 NA 1.52457044077889 2.16636808468076 -0.641797643901869 1.56554461909162 1.27771018064787 0.464249585425592 0.409951678205288 0.502302989850518 0.128603042391368 NA NA NA 0.157609429725864 95.8977906616825 a1542 gain_cnaBRCA10_(MDM2,NUP107) 170 Shikonin unknown 4 43 2.77258872223978 NA 0.86604246439861 -0.0766184540323723 0.942660918430982 1.0408851800294 1.17363571001294 0.808973044664959 0.905633912862851 0.803197201984072 0.128731404420186 NA NA NA 0.166702434373831 95.8977906616825 a1543 loss_cnaBRCA42 291 KIN001-266 MAP3K8 (COT) 3 46 2.99573227355399 NA 2.77592069888679 3.84402878135797 -1.06810808247118 0.331236758835411 1.18297839652828 0.921140176135235 3.22460612833708 0.902897369559566 0.128848417084313 NA NA NA 0.00517251071432077 95.8977906616825 a1544 gain_cnaBRCA62 207 AS601245 JNK 9 39 2.07944154167984 NA 2.85184341981489 2.13105239622794 0.720791023586943 1.69409640800219 1.14901856959985 0.571667607837944 0.425472257766579 0.627310160738273 0.128985667488614 NA NA NA 0.253427635754157 95.8977906616825 a1545 loss_cnaBRCA36_(FAT1,IRF2) 185 OSI-906 IGF1R 9 39 0.940007258491471 NA 2.37887856940376 3.01224637641042 -0.633367807006666 1.55114456337642 0.989805646377354 0.571606139307846 0.408322874579785 0.639891082986609 0.129025793306231 NA NA NA 0.269900978733295 95.8977906616825 a1546 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1067 CCT007093 PPM1D 14 32 1.88706964903238 NA 3.7523160652821 4.23146379330433 -0.479147728022229 1.16113786951194 0.873696875019426 0.495216719701166 0.412653605229177 0.548414148799119 0.129399951201235 NA NA NA 0.182336876652538 95.8977906616825 a1547 gain_cnaBRCA15 1004 Vinblastine Microtubules 21 24 -2.30258509299405 NA -3.14544522752482 -3.72691109276005 0.581465865235228 1.19517084190039 1.31238247002787 0.461765483098922 0.486512760226534 0.443061286259699 0.129587230544852 NA NA NA 0.1272358011657 95.8977906616825 a1548 loss_cnaBRCA33 1039 SL 0101-1 RSK, AURKB, PIM3 5 38 2.30258509299405 NA 4.03412745187761 4.7297100574819 -0.695582605604287 0.723896469717502 0.966200857949725 0.73583305004246 0.960886859796035 0.719915118974651 0.12960696128429 NA NA NA 0.100827499568268 95.8977906616825 a1549 gain_cnaBRCA10_(MDM2,NUP107) 293 MP470 PDGFR 5 43 2.99573227355399 NA 4.60299304123983 3.40700286549832 1.19599017574151 0.770003722830079 1.7001754108571 0.729100046122824 1.55322648486134 0.703451048700077 0.129665899713596 NA NA NA 0.0204954062304851 95.8977906616825 a1550 CDH1_mut 281 CH5424802 ALK 4 44 1.63315443905142 NA 2.80264387704993 3.64547560322889 -0.842831726178965 1.12772429817176 1.04042516039215 0.805504159693296 0.747373917140338 0.810083952469289 0.129822888028915 NA NA NA 0.233346489361787 95.8977906616825 a1551 loss_cnaBRCA18 1042 BIRB 0796 p38, JNK2 12 31 2.30258509299405 NA 4.70970637596113 4.23377846247224 0.475927913488889 0.898579983218264 0.90825189174183 0.525499820839024 0.529644463906656 0.524004318423343 0.129874951819215 NA NA NA 0.135869781376898 95.8977906616825 a1552 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1020 Lenalidomide TNFA 7 38 1.6094379124341 NA 3.88110916296778 4.32355083734242 -0.442441674374647 0.403528656548179 0.73362635583211 0.634766231880311 1.09643185730434 0.603088576163286 0.130087972852036 NA NA NA 0.0375225327626211 95.8977906616825 a1553 gain_cnaBRCA63 1021 Axitinib PDGFR, KIT, VEGFR 6 39 0.693147180559945 NA 3.13577878608075 2.35874771824474 0.777031067836015 1.52654352580566 1.08906489279516 0.676544974868933 0.509013372170913 0.713484635283498 0.130217178113154 NA NA NA 0.276528828761288 95.8977906616825 a1554 PIK3CA_mut 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 15 28 0.693147180559945 NA 3.20989412978708 2.74691399551369 0.462980134273386 0.835684034070195 0.985535479761936 0.494074790398547 0.554013377542279 0.469775207266229 0.130241817087282 NA NA NA 0.113801546837864 95.8977906616825 a1555 BRCA2_mut 1149 TW 37 BCL2, BCL2L1 5 38 1.6094379124341 NA 0.650797507221983 -0.246750261982906 0.897547769204889 1.13127470643448 1.23211402511664 0.734105002800433 0.793395064965039 0.72846161224398 0.130484837668673 NA NA NA 0.156207502422486 95.8977906616825 a1556 loss_cnaBRCA17 1175 AG-014699 PARP1, PARP2 9 34 1.6094379124341 NA 4.32180821106607 3.73974305847598 0.58206515259009 0.455555553205873 1.09910374005329 0.578372500440517 1.27770400008063 0.529581632177748 0.130542220036779 NA NA NA 0.0219960137523514 95.8977906616825 a1557 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 9 38 0.940007258491471 NA 2.45684676377341 1.75408784499242 0.702758918780991 1.26683364276933 1.22314522357923 0.570872811779926 0.554736545553639 0.574550679047368 0.130578357630353 NA NA NA 0.15830790834068 95.8977906616825 a1558 gain_cnaBRCA16 1218 JQ1 BRD2, BRD3, BRD4 16 30 0 NA 2.67226751306824 2.34369619677483 0.328571316293408 0.728705039313696 0.668013965529291 0.476670646118866 0.450897549168674 0.491862944860845 0.130774298650158 NA NA NA 0.144939526132929 95.8977906616825 a1559 loss_cnaBRCA18 1023 GW 441756 NTRK1 14 31 0.693147180559945 NA 2.79579908832112 2.16215220496021 0.633646883360916 1.01990250856991 1.37416041550124 0.496020050196637 0.621281816680112 0.461115657395637 0.130786687462111 NA NA NA 0.0941149604898199 95.8977906616825 a1560 loss_cnaBRCA20 219 AT-7519 CDK9 3 46 2.32630161961136 NA 0.139829743744369 1.77192468334164 -1.63209493959727 0.61363929179229 1.8158373806927 0.916245314688355 2.65969758036569 0.898811180423363 0.130843569132834 NA NA NA 0.0150727540328941 95.8977906616825 a1561 CDH1_mut 196 Phenformin AAPK1 (AMPK) agonist 4 44 8.29404964010203 NA 5.8912707489563 7.32117147814992 -1.42990072919362 1.08276712799308 1.81881732232942 0.803262931755775 1.32059857768674 0.786170612979593 0.130867500921753 NA NA NA 0.0681644002697723 95.8977906616825 a1562 loss_cnaBRCA60 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 3 43 2.30258509299405 NA 2.25222046701974 1.35463685353633 0.897583613483406 0.1070793247578 0.999836258526931 0.918605745901329 8.38241757233368 0.897730609215778 0.13113291836645 NA NA NA 3.61831407406114e-06 95.8977906616825 a1563 loss_cnaBRCA22_(SYNCRIP,ZNF292) 55 A-770041 SRC family 3 9 1.63315443905142 NA 1.80443177769886 3.00510790069538 -1.20067612299652 0.919062289532676 1.13518529598836 1.09613009682793 1.30641430583235 1.05769175062397 0.131162956195316 NA NA NA 0.134606378718639 95.8977906616825 a1564 CDH1_mut 279 BIX02189 MAP2K5 (MEK5) 4 45 2.99573227355399 NA 4.3761367093896 5.08524220767019 -0.709105498280591 0.680293995170479 0.896993187856237 0.801476889341661 1.04235154699975 0.790536102035862 0.131210705503775 NA NA NA 0.124488551149481 95.8977906616825 a1565 loss_cnaBRCA7_(FAS,PTEN) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 4 44 2.77258872223978 NA 0.581221918093449 -0.529049848777712 1.11027176687116 0.820436409480796 1.41442235307325 0.802521168015932 1.35326974039802 0.78496480521449 0.131214708555134 NA NA NA 0.0634409577940957 95.8977906616825 a1566 gain_cnaBRCA63 306 TG101348 JAK2 7 41 2.32630161961136 NA 3.90156184774209 3.10935940939871 0.79220243834338 1.55415987000721 1.21084434077139 0.628264967199012 0.509730339607665 0.654256217474407 0.131326461590882 NA NA NA 0.238495966284348 95.8977906616825 a1567 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1053 MK-2206 AKT1, AKT2 16 26 1.38629436111989 0.693147180559945 1.88208177211478 1.09344661021721 0.788635161897577 1.68851276372159 1.56436331063036 0.489215567336749 0.467059046778761 0.504125324685478 0.131519767059573 NA NA NA 0.141182448901984 95.8977906616825 a1568 PTEN_mut 1161 ZG-10 IRAK1 4 22 2.30258509299405 NA 1.00241516504023 2.15231885716746 -1.14990369212723 0.54710565634983 1.43393823268913 0.848511006829884 2.10179455975495 0.80191996134364 0.131606726036791 NA NA NA 0.0155184360026742 95.8977906616825 a1569 gain_cnaBRCA16 1161 ZG-10 IRAK1 10 16 2.30258509299405 NA 2.50013968352942 1.64745491765943 0.85268476586999 1.49593459043309 1.26328846639694 0.62918593009768 0.570001369928298 0.674972334942594 0.131657422190843 NA NA NA 0.152392566652562 95.8977906616825 a1570 NF1_mut 300 CX-5461 RNA Pol I 5 44 2.32630161961136 NA 5.00395705594785 3.78832077473235 1.2156362812155 0.299666754008659 1.75314522308531 0.723954177837449 4.05662711980513 0.69340307078277 0.131735163982868 NA NA NA 0.000196850604276882 95.8977906616825 a1571 gain_cnaBRCA19 177 GSK-650394 SGK3 4 43 2.77258872223978 NA 2.79138243097628 4.12821149776912 -1.33682906679284 1.73578759818911 1.66092197377599 0.802409890367129 0.77015705619023 0.804871684461884 0.131782771782025 NA NA NA 0.222405406431478 95.8977906616825 a1572 gain_cnaBRCA19 292 Masitinib KIT 4 44 2.99573227355399 NA 3.22413277472449 4.08179961836002 -0.857666843635532 0.868845354765088 1.08343103533242 0.8009978581285 0.987134061236273 0.791621077544991 0.131930058173885 NA NA NA 0.140096835823817 95.8977906616825 a1573 gain_cnaBRCA14_(RAD21) 1219 PFI-1 BRD2, BRD3, BRD4 21 26 2.30258509299405 NA 3.41657224194421 2.97533049437344 0.441241747570774 1.18678756350107 0.77665826038932 0.45008400970322 0.371795055105811 0.568128570923317 0.13201749208579 NA NA NA 0.151389680782326 95.8977906616825 a1574 PTEN_mut 193 GW-2580 CSF1R (cFMS) 9 39 2.99573227355399 NA 5.12574097233987 5.54130761257127 -0.415566640231401 0.579501297124725 0.761304157960015 0.566991413072933 0.71711080250086 0.54586151393807 0.132066929875023 NA NA NA 0.0886975080080529 95.8977906616825 a1575 gain_cnaBRCA61_(NOTCH2) 298 OSI-930 KIT, VEGFR, PDGFR 3 45 2.32630161961136 NA 4.6492690848096 3.86430717721774 0.78496190759186 0.148018865116017 0.87757590112462 0.913978232703043 5.3031207000311 0.894466115792293 0.132177501743536 NA NA NA 8.98376965996674e-05 95.8977906616825 a1576 gain_cnaBRCA15 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 21 25 1.63315443905142 NA 2.32240245484808 1.61251668976111 0.709885765086968 1.48566004995389 1.62560548653852 0.454022517394795 0.477825169431595 0.436690064696176 0.132230470717823 NA NA NA 0.129292720876879 95.8977906616825 a1577 gain_cnaBRCA10_(MDM2,NUP107) 1091 BMS-536924 IGF1R 3 44 1.38629436111989 NA 2.10243782953171 3.08608842758057 -0.983650598048861 1.70459771382022 1.03670647891343 0.914822623736694 0.57705732565156 0.948822659119309 0.132248450791359 NA NA NA 0.423282800662613 95.8977906616825 a1578 loss_cnaBRCA42 299 OSI-027 MTORC1/2 3 45 2.99573227355399 NA -0.402183675520063 1.38037977957381 -1.78256345509387 0.784968413459384 1.98759182327816 0.91376874624364 2.2708728460016 0.896845838374335 0.13226399972825 NA NA NA 0.0296973320804567 95.8977906616825 a1579 loss_cnaBRCA42 275 I-BET BRD2, BRD3, BRD4 3 46 2.99573227355399 NA 2.89415804446601 4.11360082117085 -1.21944277670485 0.557823088406053 1.36074585493047 0.912454577219338 2.18607440611563 0.896157627294155 0.13240560951947 NA NA NA 0.0345726723306335 95.8977906616825 a1580 CDH1_mut 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 5 41 2.30258509299405 NA 2.04566376320304 1.33604212895381 0.709621634249224 0.895552646996873 0.985092919434941 0.726110179433026 0.792384050930845 0.720360100300253 0.132471491470184 NA NA NA 0.156179486456419 95.8977906616825 a1581 CDH1_mut 1069 EHT 1864 Rac GTPases 5 41 2.30258509299405 NA 3.0156650299395 3.62797738332161 -0.612312353382114 0.664197653308084 0.859216035948612 0.726045454872857 0.921882741278064 0.712640741983003 0.132505121422608 NA NA NA 0.11126682711199 95.8977906616825 a1582 gain_cnaBRCA31 1049 PD-173074 FGFR1, FGFR3 13 30 0.693147180559945 NA 3.33621162860762 2.76510334645891 0.571108282148716 0.849330607674881 1.21543487831731 0.509585665982379 0.672421642394563 0.469879787339475 0.132546198761495 NA NA NA 0.0870813720816792 95.8977906616825 a1583 loss_cnaBRCA18 1241 CHIR-99021 GSK3B 15 31 2.30258509299405 NA 4.54332175171755 4.08059935414955 0.462722397567992 0.755626747329224 1.04191952460357 0.481936577680431 0.6123690025578 0.44410569784077 0.132613189215151 NA NA NA 0.0953378760226027 95.8977906616825 a1584 BRCA2_mut 282 EKB-569 EGFR 6 41 0.916290731874155 2.99573227355399 0.3643748758381 1.75568099980062 -1.39130612396252 2.29613544799984 2.05000371148691 0.669286098313349 0.605933820312945 0.678684685382045 0.132721713928856 NA NA NA 0.208038759185432 95.8977906616825 a1585 gain_cnaBRCA30_(CRNKL1,FOXA2) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 5 42 0.940007258491471 NA 2.68574541096914 1.79376742687683 0.891977984092314 1.1191896876401 1.24177772330129 0.724375407624811 0.796985527960964 0.718307284270628 0.132726944356353 NA NA NA 0.154166855186016 95.8977906616825 a1586 NF1_mut 330 XMD13-2 RIPK 4 44 2.32630161961136 NA 4.59712045299039 3.6413758617201 0.955744591270291 0.309803749146371 1.23401630300277 0.799305635921855 3.08500008119248 0.774499160946776 0.132728385149406 NA NA NA 0.00119935307405138 95.8977906616825 a1587 ASH1L_mut 172 Embelin XIAP 3 45 3.46573590279973 NA 2.17942847378089 3.04730442686432 -0.867875953083429 0.523741508183578 0.966186944520913 0.912363627991581 1.6570692594012 0.898248478728688 0.132845351101115 NA NA NA 0.0808956828215527 95.8977906616825 a1588 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 175 PAC-1 CASP3 agonist 7 41 0.940007258491471 NA 3.04355593562933 2.29174231406644 0.75181362156289 1.04170733408869 1.22393578707004 0.625606851716092 0.721712900505394 0.614259039980065 0.13292581761571 NA NA NA 0.119650339775181 95.8977906616825 a1589 gain_cnaBRCA27_(CLTC,PPM1D) 1038 NU-7441 PRKDC (DNAPK) 10 33 0.693147180559945 NA 3.2863263034666 2.77363432240209 0.51269198106451 0.753748516949773 0.969753870843622 0.553267885428158 0.680189704570489 0.528682582744942 0.133029686930097 NA NA NA 0.0953582562582236 95.8977906616825 a1590 loss_cnaBRCA22_(SYNCRIP,ZNF292) 341 EX-527 SIRT1 19 30 2.99573227355399 NA 5.81834212791455 5.5299136090147 0.288428518899846 0.649631078338198 0.639855642021764 0.4481369088743 0.443988178086656 0.450771236444041 0.133104640219842 NA NA NA 0.136000901607224 95.8977906616825 a1591 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 133 Doxorubicin DNA intercalating 6 42 0.0237165266173161 NA -2.08372398268636 -0.880205126512169 -1.20351885617419 2.01956635162748 1.77569134862888 0.667213990192509 0.595929346517548 0.677774804221188 0.133167192871752 NA NA NA 0.214087378065342 95.8977906616825 a1592 gain_cnaBRCA15 110 Roscovitine CDKs 6 7 2.77258872223978 NA 3.61903054318805 4.47516118660891 -0.85613064342086 1.09082527442174 0.812069607912397 0.90215661074006 0.7848467243067 1.0542577078112 0.133182545762921 NA NA NA 0.147322573863714 95.8977906616825 a1593 gain_cnaBRCA9_(KRAS) 176 IPA-3 PAK1, PAK2, PAK3 4 43 3.46573590279973 NA 3.41213596358589 4.59774209990299 -1.1856061363171 0.675753049470207 1.52448605130759 0.799414830539993 1.75449616875073 0.777708746695435 0.133194367830618 NA NA NA 0.0256748723414459 95.8977906616825 a1594 gain_cnaBRCA30_(CRNKL1,FOXA2) 341 EX-527 SIRT1 5 44 2.99573227355399 NA 6.05853162604448 5.59439205842261 0.464139567621869 0.672283017557811 0.640894530328853 0.721132981406072 0.690393116440661 0.724205849258397 0.133210548132899 NA NA NA 0.203167866134794 95.8977906616825 a1595 gain_cnaBRCA64_(SDHC) 283 GSK2126458 PI3K, MTOR 8 40 -2.05572501506252 0.0237165266173161 -3.84767774841858 -2.89689393512478 -0.950783813293802 1.05435194269527 1.68620328538381 0.591958120694749 0.901770817496942 0.563860728736147 0.133253884474683 NA NA NA 0.0553218336140489 95.8977906616825 a1596 gain_cnaBRCA19 1039 SL 0101-1 RSK, AURKB, PIM3 3 40 2.30258509299405 NA 3.84228183351176 4.70931934857913 -0.867037515067371 1.33610443282636 0.921354130456514 0.916709571636888 0.648929450247583 0.941046972500975 0.133351287340557 NA NA NA 0.377796808912098 95.8977906616825 a1597 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1164 XMD8-92 MAP2K5 (ERK5) 9 17 2.30258509299405 NA 4.41184156555349 3.60530232737826 0.80653923817523 1.25185825705103 1.26310352882115 0.640432622803864 0.644273609757685 0.638537712682956 0.133374436092286 NA NA NA 0.13814701340583 95.8977906616825 a1598 gain_cnaBRCA16 276 CAY10603 HDAC6 16 33 2.99573227355399 NA 0.869966189315206 1.32369662106693 -0.45373043175172 1.14524901510314 0.884382688222475 0.465245840718587 0.396184956955286 0.513047618179496 0.133408819513393 NA NA NA 0.175573556780779 95.8977906616825 a1599 loss_cnaBRCA23 225 Genentech Cpd 10 AURKA, AURKB 3 46 2.32630161961136 NA 1.66254336309424 3.10646693061321 -1.44392356751897 0.887520354424065 1.61088868772613 0.909937166613637 1.62691881974467 0.896352167918664 0.133451165433038 NA NA NA 0.0849940661104248 95.8977906616825 a1600 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 273 CUDC-101 HDAC, EGFR 7 42 1.63315443905142 NA 0.797524004345841 -0.164010597234797 0.961534601580638 2.98186304461777 1.19428160732839 0.623360330665178 0.322461020909796 0.805115473335971 0.13348444460136 NA NA NA 0.430486522532698 95.8977906616825 a1601 gain_cnaBRCA10_(MDM2,NUP107) 333 T0901317 LXR 5 43 2.32630161961136 NA 5.22126037533997 4.67894502355177 0.542315351788202 0.39882988101812 0.776736030713178 0.721684827764616 1.35976609978118 0.698197753605253 0.133514843117492 NA NA NA 0.0345772615139123 95.8977906616825 a1602 loss_cnaBRCA57 265 Tubastatin A HDAC6 5 44 2.99573227355399 NA 5.35022842735648 4.61693347808505 0.733294949271427 0.895357263666147 1.02844569187551 0.720472864447702 0.818997040654881 0.713012806669612 0.133557664302413 NA NA NA 0.145284122118974 95.8977906616825 a1603 gain_cnaBRCA62 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 9 38 2.32630161961136 NA 0.727424495242808 1.58024169785418 -0.852817202611369 1.35167992469798 1.53736388207664 0.566269324219498 0.630931322592455 0.554726966435168 0.133630604122846 NA NA NA 0.120966332997414 95.8977906616825 a1604 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 298 OSI-930 KIT, VEGFR, PDGFR 6 42 2.32630161961136 NA 4.41413406088355 3.84182918723632 0.572304873647229 0.885844721172915 0.855680704821072 0.666237179083952 0.646055521885891 0.668829939044729 0.133722321597575 NA NA NA 0.184600723482326 95.8977906616825 a1605 loss_cnaBRCA57 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 5 43 0.246860077931526 2.32630161961136 0.784575938772598 -0.386989988821048 1.17156592759365 1.49999883294515 1.63674339911426 0.720826424995828 0.781044559410323 0.715790836992319 0.133966243327947 NA NA NA 0.160616142039792 95.8977906616825 a1606 loss_cnaBRCA18 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 7 19 2.30258509299405 NA 4.20450841366273 4.86310669212931 -0.65859827846658 1.4198764797241 0.746874063144404 0.685750501735779 0.463841952360922 0.881806332507819 0.133995142097236 NA NA NA 0.279321623208624 95.8977906616825 a1607 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1066 AZD6482 PI3Kbeta 5 38 1.6094379124341 NA 2.87369356954146 1.84791054172139 1.02578302782008 2.00536621505788 1.3310073519186 0.726960287253262 0.511519053286967 0.77068171437329 0.13416535283495 NA NA NA 0.322266968155898 95.8977906616825 a1608 NF1_mut 309 Y-39983 ROCK 5 44 2.99573227355399 NA 5.62304021385382 4.85679237195647 0.766247841897353 0.534523848388252 1.10186170723546 0.719208024809653 1.43351478929858 0.695411989422743 0.134224785836591 NA NA NA 0.0282695974942276 95.8977906616825 a1609 gain_cnaBRCA9_(KRAS) 177 GSK-650394 SGK3 4 43 2.77258872223978 NA 2.79912969882522 4.12749082169015 -1.32836112286493 2.01714860709885 1.63865942408951 0.79706365960909 0.658534090245057 0.810638930418994 0.134310947379462 NA NA NA 0.281851774086338 95.8977906616825 a1610 loss_cnaBRCA22_(SYNCRIP,ZNF292) 300 CX-5461 RNA Pol I 19 30 2.32630161961136 NA 4.3717417038581 3.62142689982195 0.750314804036152 1.06131637082423 1.96812048838494 0.446693894217752 0.706966202220594 0.38123418178115 0.134328444580754 NA NA NA 0.090569443903057 95.8977906616825 a1611 loss_cnaBRCA33 328 SNX-2112 HSP90 6 42 0.940007258491471 NA -0.749858228351396 0.583968268918077 -1.33382649726947 2.76170791863018 1.89253664922147 0.665135938403706 0.482971601837987 0.704782387077243 0.134350380264714 NA NA NA 0.297981147287629 95.8977906616825 a1612 gain_cnaBRCA30_(CRNKL1,FOXA2) 197 Bryostatin 1 PRKC 5 43 -4.8283137373023 NA -2.19407375004917 -2.87805161763026 0.683977867581098 1.16756412401908 0.92670067084937 0.719921754437591 0.585816105094647 0.73807852858701 0.134443292605358 NA NA NA 0.266287438477315 95.8977906616825 a1613 gain_cnaBRCA62 1143 HG-5-88-01 EGFR, ADCK4 4 22 2.30258509299405 NA 5.20827791400363 4.41149507159295 0.796782842410686 1.11656818004063 0.919530966359372 0.841903228442169 0.713599811147847 0.866510070417015 0.134498379896359 NA NA NA 0.253232488353629 95.8977906616825 a1614 gain_cnaBRCA63 1143 HG-5-88-01 EGFR, ADCK4 4 22 2.30258509299405 NA 5.20827791400363 4.41149507159295 0.796782842410686 1.11656818004063 0.919530966359372 0.841903228442169 0.713599811147847 0.866510070417015 0.134498379896359 NA NA NA 0.253232488353629 95.8977906616825 a1615 POLR2B_mut 1023 GW 441756 NTRK1 3 42 0.693147180559945 NA 3.44651883459347 2.28162735920195 1.16489147539153 0.597057794917252 1.30226788328029 0.911406714428568 1.95105312301127 0.894509870317368 0.134562445897288 NA NA NA 0.0497200816257195 95.8977906616825 a1616 loss_cnaBRCA29_(MAP2K4) 1170 CCT018159 HSP90 7 36 2.30258509299405 NA 3.95973715209796 3.22287393267643 0.736863219421526 0.893940880359539 1.20947851336629 0.630532665103709 0.824286298580688 0.609240438154328 0.134583848271761 NA NA NA 0.0883943745418231 95.8977906616825 a1617 gain_cnaBRCA10_(MDM2,NUP107) 253 XMD14-99 EPHB3, CAMK1 5 43 2.32630161961136 NA 5.42304687308264 4.87613148756487 0.546915385517763 0.294437682384485 0.790203252439493 0.719586728547905 1.85749113730486 0.692119886661237 0.134620301689573 NA NA NA 0.00929779960516925 95.8977906616825 a1618 TP53_mut 293 MP470 PDGFR 37 11 2.99573227355399 NA 3.72825236004401 2.87006828190894 0.858184078135074 1.64685406311412 1.62179790345463 0.522824034445382 0.521105116328457 0.529155991820582 0.134751384536246 NA NA NA 0.143488656109736 95.8977906616825 a1619 loss_cnaBRCA42 312 AV-951 VEGFR 3 45 -2.05572501506252 NA 0.095437219840071 0.668065090321969 -0.572627870481898 0.115349383129391 0.644507323052332 0.907781386197191 4.9642907048715 0.888473800064801 0.134755407484571 NA NA NA 0.000164621406146901 95.8977906616825 a1620 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1058 GDC0941 PI3K (class 1) 5 38 1.38629436111989 0.693147180559945 2.2183439416673 1.23122081005572 0.987123131611579 0.826448819923542 1.40589105103174 0.72568198208173 1.19441531987777 0.702133448311773 0.134832554705029 NA NA NA 0.0547443151440094 95.8977906616825 a1621 loss_cnaBRCA24 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 3 40 1.6094379124341 NA 4.20018820594735 2.85183547678497 1.34835272916238 0.470326288584009 1.51048762176997 0.912996254087914 2.86684534096916 0.892660561880277 0.134888069808363 NA NA NA 0.00945357191527452 95.8977906616825 a1622 loss_cnaBRCA22_(SYNCRIP,ZNF292) 176 IPA-3 PAK1, PAK2, PAK3 18 29 3.46573590279973 NA 4.91495545618325 4.23731917030598 0.677636285877272 1.47771046301295 1.48688126686488 0.456805712944945 0.458571758702728 0.455743374389324 0.134915356820412 NA NA NA 0.136006193346891 95.8977906616825 a1623 CDH1_mut 333 T0901317 LXR 4 44 2.32630161961136 NA 4.18796625791829 4.78520620131256 -0.597239943394274 0.652027611150655 0.758052877537667 0.794630820319234 0.915973393121043 0.787860532017567 0.134953875778192 NA NA NA 0.163086015002567 95.8977906616825 a1624 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 346 THZ-2-102-1 CDK7 6 42 0.916290731874155 2.99573227355399 -2.78872409203926 -1.12750528819873 -1.66121880384053 1.66499773296457 2.58527993487068 0.664035376998416 0.997730369808186 0.642568250127862 0.134980402836437 NA NA NA 0.0646154183879203 95.8977906616825 a1625 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 35 NVP-TAE684 ALK 3 11 0.693147180559945 NA 2.7066654294023 1.5184098464539 1.1882555829484 0.756954450318203 1.20012077021427 1.04388156474741 1.56978479015334 0.990113338956913 0.134987912591951 NA NA NA 0.088327592999022 95.8977906616825 a1626 gain_cnaBRCA30_(CRNKL1,FOXA2) 1373 Dabrafenib BRAF 5 41 2.30258509299405 NA 5.24726713318759 4.08865278987005 1.15861434331754 0.822862664335441 1.66447260569535 0.721298991803172 1.40802881639217 0.696084957693562 0.134990009841678 NA NA NA 0.0307216868251043 95.8977906616825 a1627 loss_cnaBRCA18 1133 JNJ-26854165 MDM2 14 29 2.30258509299405 NA 3.2552270334763 2.83054827957862 0.424678753897684 0.917593549260254 0.825587692148452 0.496217517889741 0.462817937462673 0.514395694044965 0.134996915029511 NA NA NA 0.155267688890303 95.8977906616825 a1628 gain_cnaBRCA62 256 JW-7-24-1 LCK 10 38 2.32630161961136 NA 1.34776216742021 1.96646569738164 -0.618703529961432 0.603762023569319 1.24056979214797 0.540724188369625 1.02474734383554 0.498725290489449 0.135001354911123 NA NA NA 0.0331392073372916 95.8977906616825 a1629 loss_cnaBRCA33 158 PF-562271 FAK 6 39 0.940007258491471 NA 1.60051396773312 2.44597885752613 -0.845464889793008 0.831448934993645 1.31212799811502 0.668008613087505 1.01685726472122 0.644346352648206 0.135006438597367 NA NA NA 0.0620180412714446 95.8977906616825 a1630 gain_cnaBRCA30_(CRNKL1,FOXA2) 150 Bicalutamide ANDR (androgen receptor) 5 43 0.0237165266173161 NA 3.15727778307362 2.71669355279911 0.440584230274507 0.976823616390111 0.566233916101337 0.718787717614859 0.451037651917859 0.778095797065707 0.135043205783637 NA NA NA 0.374614256148745 95.8977906616825 a1631 CDH1_mut 151 QS11 ARFGAP 4 44 2.32630161961136 NA 2.70033011249209 3.85682441823409 -1.156494305742 0.621968322140924 1.49680955449982 0.794367438894149 1.85941030205709 0.772639580142484 0.135080142127303 NA NA NA 0.0201514291799562 95.8977906616825 a1632 gain_cnaBRCA30_(CRNKL1,FOXA2) 1025 SB 216763 GSK3A, GSK3B 4 35 2.30258509299405 NA 5.44640091078584 4.8254768100968 0.620924100689044 1.12854209658667 0.730221062195587 0.806154327227385 0.550200211907966 0.850323460709398 0.135168472621165 NA NA NA 0.354755179269438 95.9017000294405 a1633 gain_cnaBRCA16 59 WZ-1-84 BMX 3 9 2.32630161961136 NA 2.66022526048879 3.86245428751939 -1.2022290270306 1.75440349157074 0.877774134676618 1.08314360177319 0.685263699489237 1.3696336899623 0.135285360359206 NA NA NA 0.357232570092682 95.9121203276434 a1634 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1038 NU-7441 PRKDC (DNAPK) 6 37 0.693147180559945 NA 3.42704068672057 2.80624193388139 0.620798752839181 1.31747706300994 0.858868369697046 0.669668562965609 0.471202702702762 0.722810124045153 0.135783716745517 NA NA NA 0.309029439009371 95.9121203276434 a1635 gain_cnaBRCA58_(CCND1) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 9 38 -2.30258509299405 NA 0.323174347892165 -0.25044848499022 0.573622832882385 0.574292738048713 1.09208985128212 0.562682325484736 0.998833512733237 0.52525241600675 0.136048219846836 NA NA NA 0.0378247894143326 95.9121203276434 a1636 gain_cnaBRCA62 45 Z-LLNle-CHO g-secretase 4 8 0.940007258491471 NA 0.0448266426310397 1.43987015549789 -1.39504351286685 0.827471619232918 1.59035338529542 0.992449973373884 1.68591100944354 0.877190897171393 0.136157117500605 NA NA NA 0.0739437553522216 95.9121203276434 a1637 TP53_mut 1061 SB590885 BRAF 33 9 1.6094379124341 NA 4.14266460343532 3.53248437067293 0.610180232762389 0.850991569610435 1.67199859810019 0.57187124191487 0.717022652811609 0.364940636586483 0.136194176749891 NA NA NA 0.3171246001219 95.9121203276434 a1638 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1026 17-AAG HSP90 15 28 0 NA -1.45100788451636 -0.598991703284505 -0.852016181231859 1.46422116753366 1.88535541940168 0.486042644150082 0.581890359273389 0.451912765340685 0.136430792974716 NA NA NA 0.109841147608497 95.9121203276434 a1639 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 219 AT-7519 CDK9 15 34 2.32630161961136 NA 1.09115805917549 1.92825452286224 -0.837096463686746 1.59483601051023 1.85643556748757 0.469611028730911 0.524879334408143 0.450915980251144 0.136458123282664 NA NA NA 0.117912919794929 95.9121203276434 a1640 gain_cnaBRCA14_(RAD21) 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 6 8 1.38629436111989 NA 1.5504608885099 2.19817574792701 -0.647714859417116 0.901244765106171 0.622871057132228 0.861898429942487 0.718689178006834 1.03988594750135 0.136489039324262 NA NA NA 0.167364179870476 95.9121203276434 a1641 gain_cnaBRCA30_(CRNKL1,FOXA2) 309 Y-39983 ROCK 5 44 2.99573227355399 NA 5.61893439711688 4.85725894204022 0.761675455076668 0.736449082148496 1.09130887258343 0.714706259456617 1.03425406255457 0.697946726368652 0.136620777947233 NA NA NA 0.0824394973556432 95.9121203276434 a1642 gain_cnaBRCA48 1241 CHIR-99021 GSK3B 5 41 2.30258509299405 NA 3.61676580559644 4.30645310308335 -0.689687297486907 1.06860545371033 0.949188986052839 0.717931718571048 0.645408738175748 0.726606932466569 0.136775340159339 NA NA NA 0.228833524606202 95.9121203276434 a1643 gain_cnaBRCA16 1001 AICAR AAPK1 (AMPK) agonist 15 30 7.60090245954208 NA 8.17198124461877 7.5217343212402 0.650246923378567 1.41342180126637 1.327665475897 0.479468909352308 0.46005157327839 0.489767140280006 0.136782963670042 NA NA NA 0.149516682882894 95.9121203276434 a1644 PIK3CA_mut 17 Cyclopamine SMO 4 9 2.77258872223978 NA 5.20675872626287 4.46847657802504 0.738282148237832 0.349148265373051 0.871787485548828 0.964449723494549 2.114523317047 0.846860227378752 0.136809119568739 NA NA NA 0.05207008185421 95.9121203276434 a1645 loss_cnaBRCA7_(FAS,PTEN) 164 JQ12 HDAC 4 43 1.63315443905142 NA 2.74676110663621 1.46915034011423 1.27761076652199 1.28440085373376 1.6345189661148 0.791804579088807 0.994713420508845 0.781643280382867 0.136835583044501 NA NA NA 0.137872894221138 95.9121203276434 a1646 gain_cnaBRCA30_(CRNKL1,FOXA2) 175 PAC-1 CASP3 agonist 5 43 0.940007258491471 NA 3.17190710932707 2.31178583440683 0.860121274920232 0.992928398060253 1.22040090036763 0.715378505758868 0.866247029091456 0.704785840997932 0.136859574419901 NA NA NA 0.128619577036575 95.9121203276434 a1647 gain_cnaBRCA58_(CCND1) 1375 Temozolomide DNA akylating agent 9 37 3.40119738166216 NA 6.21083431901672 5.82454822048677 0.386286098529957 0.444593738638216 0.728773875755892 0.563165992532338 0.868851863980689 0.530049321717655 0.136864811807919 NA NA NA 0.0562168082812717 95.9121203276434 a1648 ASH1L_mut 185 OSI-906 IGF1R 3 45 0.940007258491471 NA 1.95476132875087 2.95607181818639 -1.00131048943552 1.86896280274576 1.06178556721191 0.902762380193234 0.535757313074644 0.943043982095948 0.136872614948834 NA NA NA 0.451982894453568 95.9121203276434 a1649 loss_cnaBRCA36_(FAT1,IRF2) 1241 CHIR-99021 GSK3B 9 37 2.30258509299405 NA 3.79642670175451 4.33731259293537 -0.540885891180865 0.845347752967888 0.984478460289484 0.563022899064295 0.639838326040256 0.549413636761355 0.136962093270759 NA NA NA 0.118520764161169 95.9121203276434 a1650 loss_cnaBRCA17 1019 Bosutinib SRC, ABL, TEC 8 37 0.693147180559945 NA 3.10836028180651 2.566217619581 0.542142662225507 0.698203712806861 0.954296966608283 0.590896674508434 0.776482067169237 0.568106869450047 0.136967329314267 NA NA NA 0.0859905340656295 95.9121203276434 a1651 gain_cnaBRCA15 104 Bortezomib Proteasome 6 8 -3.91202300542815 NA -5.38442934259194 -3.96242834201416 -1.42200100057778 1.32147714288686 1.8532830247711 0.86044881035525 1.07606931245993 0.767287554880296 0.137090489065356 NA NA NA 0.119712198641857 95.9121203276434 a1652 gain_cnaBRCA62 152 CP466722 ATM 10 39 2.77258872223978 NA 2.28462025379194 2.84437804449398 -0.559757790702041 0.513508495121251 1.1339798927678 0.536109841726888 1.09006529788737 0.493622324586193 0.137108805716903 NA NA NA 0.0279930900129569 95.9121203276434 a1653 gain_cnaBRCA27_(CLTC,PPM1D) 1030 KU-55933 ATM 10 32 2.30258509299405 NA 4.60109405490313 4.10392601134312 0.497168043560008 0.889143029628485 0.909139431074164 0.549552013420265 0.55915418216543 0.546855659942717 0.137154160088743 NA NA NA 0.145086449515218 95.9121203276434 a1654 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 190 Bleomycin DNA damage 9 39 4.15888308335967 NA 3.30478499345174 1.79538704007042 1.50939795338132 2.68802469797016 2.70015044321683 0.559441245570256 0.561526817265157 0.559005131426341 0.137165947420554 NA NA NA 0.15506972499537 95.9121203276434 a1655 gain_cnaBRCA19 290 KIN001-260 IKK 4 45 2.99573227355399 NA 4.30134744957283 5.11009374038391 -0.808746290811082 0.445841795303605 1.05296664381181 0.789009148432788 1.81397594243122 0.768064492416749 0.137168702487934 NA NA NA 0.022392184461683 95.9121203276434 a1656 BRCA1_mut 275 I-BET BRD2, BRD3, BRD4 4 45 2.99573227355399 NA 5.00778758551784 3.95282136811524 1.0549662174026 0.94080336432814 1.36006273816785 0.78891627725525 1.12134613608231 0.775674671319756 0.137213878323238 NA NA NA 0.10504975624115 95.9121203276434 a1657 loss_cnaBRCA17 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 10 36 1.63315443905142 NA 1.2742168338931 2.12058890158074 -0.846372067687631 1.36789350373118 1.6113085999386 0.540950045844368 0.618741199792961 0.525269999626316 0.137350032976735 NA NA NA 0.115168445542029 95.9121203276434 a1658 POLR2B_mut 175 PAC-1 CASP3 agonist 3 45 0.940007258491471 NA 1.38516633207115 2.46912949844257 -1.08396316637142 1.50506821342154 1.186823139391 0.901490158118466 0.72020866343805 0.913331675457254 0.137413476411488 NA NA NA 0.337729361760884 95.9121203276434 a1659 gain_cnaBRCA19 185 OSI-906 IGF1R 4 44 0.940007258491471 NA 2.09070227968539 2.9664706064977 -0.875768326812314 0.884138249692554 1.12326033947173 0.789522589376508 0.990533241963968 0.779666383684645 0.137419645585595 NA NA NA 0.139097842201115 95.9121203276434 a1660 PTEN_mut 341 EX-527 SIRT1 9 40 2.99573227355399 NA 5.34875711153484 5.7076773674251 -0.35892025589026 0.699617974824458 0.631947766260367 0.557356873145341 0.513023205243285 0.567958738131502 0.137552145791094 NA NA NA 0.184523213839383 95.9467648262095 a1661 MACF1_mut 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 42 2.30258509299405 NA 4.25602860346305 3.09978400498682 1.15624459847623 1.6448137420272 1.25873767344171 0.903823841688995 0.702963848691571 0.918574714074262 0.137751027070857 NA NA NA 0.346972177203016 95.9503733227613 a1662 loss_cnaBRCA18 1149 TW 37 BCL2, BCL2L1 14 29 1.6094379124341 NA 0.264194195615834 -0.338663488202144 0.602857683817979 1.40065337047201 1.13252708873036 0.492563404545108 0.430411761058926 0.532311933036252 0.137816458922343 NA NA NA 0.174580472340734 95.9503733227613 a1663 PTEN_mut 140 Vinorelbine Microtubules 8 39 -2.74887219562247 NA -4.38720388961664 -3.43830188005951 -0.948902009557131 0.885600198401886 1.7197713448899 0.586285024246569 1.07147899387272 0.551760565366253 0.1378920551797 NA NA NA 0.0341170308832599 95.9503733227613 a1664 TP53_mut 35 NVP-TAE684 ALK 9 5 0.693147180559945 NA 2.13401563344704 1.12327277963529 1.01074285381175 1.12061748970914 1.17760810154663 0.88667021634015 0.901951703497056 0.858301545721604 0.137896525308124 NA NA NA 0.156011762980471 95.9503733227613 a1665 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 326 GSK690693 AKT 7 41 2.32630161961136 NA 1.9389610584466 3.11041533208107 -1.17145427363446 2.33697299879027 1.82303589617742 0.617211147744203 0.501269922348638 0.64258431558632 0.138079871425769 NA NA NA 0.245678731768424 95.9503733227613 a1666 gain_cnaBRCA16 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 16 31 2.77258872223978 NA 5.31943693604942 4.85165737807398 0.467779557975434 0.976044722266554 1.02296422531574 0.464266367290713 0.479260373325071 0.457278511211918 0.138492503489064 NA NA NA 0.135566860752873 95.9503733227613 a1667 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 266 Zibotentan, ZD4054 Endothelin A Receptor 7 42 2.99573227355399 NA 5.99755499231399 5.69945344986782 0.298101542446163 0.694047250507431 0.445698918927412 0.615221839158031 0.429511884426047 0.668840622641746 0.13850836718639 NA NA NA 0.308800281288053 95.9503733227613 a1668 gain_cnaBRCA63 1043 JNK Inhibitor VIII JNK 5 38 2.30258509299405 NA 5.2624031016841 4.73613750742546 0.526265594258639 1.30712498934127 0.63983967436886 0.718727372225023 0.402613061910669 0.822496033522381 0.138509164298623 NA NA NA 0.422654826589591 95.9503733227613 a1669 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 186 Bexarotene Retinioic acid X family agonist 6 41 2.07944154167984 NA 2.95990548066005 3.69872253270253 -0.738817052042478 0.755488527219693 1.15860998369787 0.659069316281785 0.977932854601289 0.637675371728143 0.138589504858957 NA NA NA 0.0691341579087568 95.9503733227613 a1670 ASH1L_mut 1053 MK-2206 AKT1, AKT2 3 39 1.38629436111989 0.693147180559945 2.75031745712706 1.28953763713084 1.46077981999622 0.948108148478384 1.64128459086627 0.905228981399292 1.54073121546379 0.890022259470078 0.138682265045252 NA NA NA 0.0948158521813028 95.9503733227613 a1671 loss_cnaBRCA57 298 OSI-930 KIT, VEGFR, PDGFR 5 43 2.32630161961136 NA 4.4615291906156 3.84962754130579 0.611901649309807 0.834292280529406 0.861914257266195 0.711888044915139 0.733437985212474 0.709933318948252 0.138739345869682 NA NA NA 0.18203482948507 95.9503733227613 a1672 loss_cnaBRCA57 292 Masitinib KIT 5 43 2.99573227355399 NA 4.69368360890438 3.93086735493528 0.762816253969096 1.10215995383907 1.06872005391701 0.711801913193939 0.692110297885561 0.713766202078145 0.138785990114372 NA NA NA 0.202638429217774 95.9503733227613 a1673 loss_cnaBRCA38 1072 BMS-708163 g-secretase 3 43 1.6094379124341 NA 2.89474917910833 3.7393312054097 -0.844582026301367 1.04536998911294 0.933198349240529 0.899843261435916 0.807926413707407 0.905040206070573 0.138984349745653 NA NA NA 0.294514949839785 95.9503733227613 a1674 BRCA1_mut 1032 Afatinib ERBB2, EGFR 4 41 -0.693147180559945 NA 1.58500539036869 0.164175728446501 1.42082966192218 0.750954538761459 1.8546587646625 0.78945701977879 1.8920315259903 0.766086834405218 0.139095333686277 NA NA NA 0.0186816212443642 95.9503733227613 a1675 gain_cnaBRCA63 172 Embelin XIAP 6 42 3.46573590279973 NA 3.54018910992143 2.91490118977877 0.625287920142664 1.1800197110898 0.920324217561004 0.656822038366461 0.529896165518439 0.679421347620049 0.139168281405102 NA NA NA 0.260287002235701 95.9503733227613 a1676 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 282 EKB-569 EGFR 5 42 0.916290731874155 2.99573227355399 0.254269406215644 1.73566245751847 -1.48139305130282 2.39313989946471 2.04748331956512 0.712025029022484 0.61901648609602 0.723518984085041 0.139294076721141 NA NA NA 0.244862919136489 95.9503733227613 a1677 gain_cnaBRCA14_(RAD21) 1003 Camptothecin TOP1 20 25 -2.30258509299405 NA -2.13754377585272 -2.84267157857074 0.705127802718027 1.60563874121489 1.52422803015244 0.451795341119558 0.439157193095937 0.462613066266409 0.13938257769447 NA NA NA 0.142241211763164 95.9503733227613 a1678 loss_cnaBRCA23 1259 BMN-673 PARP1 3 43 2.30258509299405 NA 4.59144736167982 3.21582343669312 1.3756239249867 1.15398382964497 1.54604384304348 0.898863600755444 1.19206516560108 0.889770320018032 0.139404378000174 NA NA NA 0.163600503949214 95.9503733227613 a1679 gain_cnaBRCA27_(CLTC,PPM1D) 292 Masitinib KIT 9 39 2.99573227355399 NA 3.52610791980675 4.12207033406355 -0.595962414256794 1.15784350926859 1.05274362809256 0.55605829808037 0.514717584445643 0.566104033644546 0.139500943457101 NA NA NA 0.184112840519135 95.9503733227613 a1680 ASH1L_mut 260 NG-25 MAP3K7 (TAK1) 3 46 2.32630161961136 NA 2.14552341784337 3.27765775164263 -1.13213433379926 0.606870352931247 1.28620934348812 0.895140090359034 1.86552915022283 0.880210005883632 0.13973072892783 NA NA NA 0.05798111618444 95.9503733227613 a1681 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 5 42 2.32630161961136 NA 0.459127880222457 1.5309610851079 -1.07183320488544 1.39512858888714 1.51769250646399 0.711141241826623 0.768268397209478 0.706225536675188 0.13977376313049 NA NA NA 0.166468327963497 95.9503733227613 a1682 gain_cnaBRCA19 308 XL-880 MET 4 45 1.63315443905142 NA 0.711508247748218 1.94872662300208 -1.23721837525386 0.545096873486882 1.62551947079316 0.783642957338926 2.26972201718862 0.761121842883964 0.139798492049793 NA NA NA 0.00769014333622387 95.9503733227613 a1683 loss_cnaBRCA23 1133 JNJ-26854165 MDM2 3 40 2.30258509299405 NA 3.68630749818302 2.91500390204748 0.771303596135546 0.81465709748914 0.858527192424741 0.900593390922927 0.946783129383868 0.898403222333763 0.140124154224166 NA NA NA 0.237490307544256 95.9503733227613 a1684 ARID1A_mut 190 Bleomycin DNA damage 5 43 4.15888308335967 NA 0.363410577249164 2.27781643296666 -1.91440585571749 2.96468754283695 2.672350555663 0.709294440813606 0.645736128362983 0.716375271822277 0.140149375986562 NA NA NA 0.228494710656389 95.9503733227613 a1685 loss_cnaBRCA28_(GPS2) 1129 PF-4708671 RPS6KB1 (p70S6KA) 4 39 2.30258509299405 NA 3.00376393861964 3.89155184485691 -0.887787906237272 1.1190347456022 1.12444498021688 0.789811763051088 0.793351510957344 0.789534323027561 0.140153914642856 NA NA NA 0.212075921318633 95.9503733227613 a1686 gain_cnaBRCA30_(CRNKL1,FOXA2) 1039 SL 0101-1 RSK, AURKB, PIM3 4 39 2.30258509299405 NA 5.32693084406492 4.57927938634463 0.747651457720289 0.777007483483498 0.958836372328022 0.789730904513077 0.962219120938708 0.779748744725877 0.140193440935174 NA NA NA 0.147948891533154 95.9503733227613 a1687 loss_cnaBRCA38 1028 VX-702 p38 3 42 0.693147180559945 NA 2.86363459874307 3.46705977702354 -0.603425178280471 0.782158064269346 0.666066123687784 0.898073516247458 0.771487511087879 0.905953863768823 0.14020899666247 NA NA NA 0.311670865734599 95.9503733227613 a1688 gain_cnaBRCA19 176 IPA-3 PAK1, PAK2, PAK3 4 43 3.46573590279973 NA 3.43091018103999 4.59599566107005 -1.16508548003006 0.838653771535747 1.52007878833147 0.78487883723996 1.38923298215967 0.766463876065873 0.140217869641954 NA NA NA 0.058478072507521 95.9503733227613 a1689 gain_cnaBRCA12_(TERT) 1019 Bosutinib SRC, ABL, TEC 10 35 0.693147180559945 NA 2.27794767209597 2.77249878451399 -0.494551112418019 0.857648897363089 0.933178913037758 0.538794352815447 0.576635863391834 0.52996387456733 0.140244698069335 NA NA NA 0.134965524476345 95.9503733227613 a1690 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1377 Afatinib (rescreen) ERBB2, EGFR 9 38 2.30258509299405 NA 3.71440322875987 2.62627518556021 1.08812804319966 1.80388277653254 1.98635282724859 0.556542048677481 0.603214386963262 0.547801995835197 0.140267608610724 NA NA NA 0.134674150219548 95.9503733227613 a1691 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 151 QS11 ARFGAP 6 42 2.32630161961136 NA 2.92558317632333 3.87971656653163 -0.954133390208295 1.65848873931266 1.43025773055321 0.654952196217391 0.575302905344853 0.667105913728739 0.140270561888995 NA NA NA 0.227978300663053 95.9503733227613 a1692 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 256 JW-7-24-1 LCK 5 43 2.32630161961136 NA 1.11053558325325 1.92210791298693 -0.811572329733683 1.08579863784352 1.15045198219516 0.708812339777898 0.747442759133985 0.705437812524027 0.140412724134656 NA NA NA 0.175597741902301 95.9503733227613 a1693 NF1_mut 1043 JNK Inhibitor VIII JNK 4 39 2.30258509299405 NA 5.32157617001197 4.74356246437282 0.578013705639147 0.394323255040987 0.752663900497644 0.789190878211712 1.46583722428206 0.767957258554553 0.140457651442741 NA NA NA 0.0492657241028275 95.9503733227613 a1694 CDH1_mut 298 OSI-930 KIT, VEGFR, PDGFR 4 44 2.32630161961136 NA 3.29636028629943 3.96945884281885 -0.673098556519421 0.66984562330607 0.871454471628727 0.782901811016877 1.00485624314047 0.772385223133248 0.140668768895984 NA NA NA 0.134908592222218 95.9503733227613 a1695 POLR2B_mut 1008 Methotrexate Dihydrofolate reductase (DHFR) 3 42 -1.6094379124341 NA -0.213609730006002 0.746668631909567 -0.960278361915569 0.195765904463575 1.09571251119783 0.896819322115845 4.90523804207305 0.876396273750488 0.140749712897968 NA NA NA 0.00020146105967033 95.9503733227613 a1696 loss_cnaBRCA34 1005 Cisplatin DNA crosslinker 5 40 1.79175946922805 2.30258509299405 4.40526128427902 3.57818633499954 0.827074949279475 1.05112687302591 1.17300743471407 0.711640447054855 0.786845975023502 0.705089264401026 0.140851917783448 NA NA NA 0.15901217688943 95.9503733227613 a1697 TP53_mut 71 Pyrimethamine Dihydrofolate reductase (DHFR) 9 5 2.99573227355399 NA 4.86506338398322 4.03764386805394 0.827419515929278 0.905592566161443 1.00813912714993 0.879282002490993 0.913677460313617 0.820739413485956 0.140913735840428 NA NA NA 0.167615065580137 95.9503733227613 a1698 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 329 QL-XI-92 DDR1 5 43 2.32630161961136 NA 3.66292863333109 4.32198701271144 -0.65905837938035 1.35375365173655 0.880683893990788 0.707593560829799 0.486837748164099 0.748348395919732 0.141080236377417 NA NA NA 0.342674141906344 95.9503733227613 a1699 CDH1_mut 271 VNLG/124 HDAC, RAR 4 45 1.63315443905142 NA 3.57741728984207 4.202464355923 -0.625047066080929 0.702428769336177 0.806628592746697 0.780935008678219 0.889836939155586 0.774888308821965 0.141140687324794 NA NA NA 0.172445113362647 95.9503733227613 a1700 gain_cnaBRCA30_(CRNKL1,FOXA2) 208 SB-715992 KIF11 5 44 -2.05572501506252 NA -0.173795500855504 -1.36104744069335 1.18725193983784 2.28898520753621 1.6130031542993 0.706214568151767 0.518680477238979 0.736050600194638 0.141232967137874 NA NA NA 0.316129873659551 95.9503733227613 a1701 BRCA2_mut 194 AUY922 HSP90 6 41 -1.36257783450257 NA -3.36382773604146 -2.25178405121847 -1.11204368482299 1.79354643169081 1.68697884092738 0.654470665217273 0.620025032624691 0.659192431964154 0.141297202632472 NA NA NA 0.200175245011704 95.9503733227613 a1702 gain_cnaBRCA58_(CCND1) 305 TPCA-1 IKK 10 39 2.99573227355399 NA 4.75194050339584 4.03124581752079 0.72069468587505 1.50686748764889 1.32188898919235 0.530210872640674 0.478273432655662 0.545200611978304 0.141382520356982 NA NA NA 0.190583176974235 95.9503733227613 a1703 gain_cnaBRCA31 1114 Cetuximab EGFR 14 31 4.18661983833127 NA 6.56907628771879 6.1532019178363 0.415874369882489 0.627325457837957 0.94663329569657 0.482086885766336 0.662932397667675 0.439319398306682 0.141660497676612 NA NA NA 0.0899519736504246 95.9503733227613 a1704 loss_cnaBRCA23 150 Bicalutamide ANDR (androgen receptor) 3 45 0.0237165266173161 NA 2.24991514235095 2.79676591685949 -0.546850774508538 0.914558279749501 0.596169290913202 0.89142320581245 0.597939777723429 0.917274309233341 0.141753487206337 NA NA NA 0.409515196346818 95.9503733227613 a1705 gain_cnaBRCA30_(CRNKL1,FOXA2) 1003 Camptothecin TOP1 5 40 -2.30258509299405 NA -1.54401625772821 -2.65243959231705 1.10842333458884 1.50241971431166 1.56710523188421 0.709981166099232 0.737758779407835 0.707306256170254 0.141757396104273 NA NA NA 0.180642448025824 95.9503733227613 a1706 gain_cnaBRCA13_(FGFR1,WHSC1L1) 154 CHIR-99021 GSK3B 10 37 0.940007258491471 NA 3.6491563226107 3.17443159889019 0.474724723720508 0.820396966895207 0.907991248083867 0.532703390749958 0.578652460792369 0.522829624979667 0.141987685651352 NA NA NA 0.132887901299303 95.9503733227613 a1707 gain_cnaBRCA27_(CLTC,PPM1D) 71 Pyrimethamine Dihydrofolate reductase (DHFR) 3 11 2.99573227355399 NA 5.32672488340558 4.36305592235473 0.963668961050857 0.317530899544922 1.02157252661007 1.02351327855382 3.03488247106648 0.943319182876468 0.142071079184478 NA NA NA 0.0206933902246947 95.9503733227613 a1708 loss_cnaBRCA17 201 Epothilone B Microtubules 11 37 -3.44201937618241 NA -4.93738162719246 -4.02716709432406 -0.910214532868403 1.43818470796975 1.85865808654777 0.512583062239161 0.632891260645742 0.489715961992244 0.142371636932748 NA NA NA 0.100934247345365 95.9503733227613 a1709 ASH1L_mut 262 VX-11e ERK 3 46 1.63315443905142 NA 2.68372440685456 3.84810026228271 -1.16437585542815 1.36271023517638 1.30747095098657 0.888925413213253 0.854455940354366 0.890555812769341 0.142437138548752 NA NA NA 0.274115978340032 95.9503733227613 a1710 loss_cnaBRCA42 190 Bleomycin DNA damage 3 45 4.15888308335967 NA -0.173453877015749 2.22852269188576 -2.40197656890151 1.55713220120095 2.74043215082726 0.889690027798005 1.54256431602209 0.87649554402448 0.142511545542359 NA NA NA 0.0959084274239217 95.9503733227613 a1711 gain_cnaBRCA62 185 OSI-906 IGF1R 9 39 0.940007258491471 NA 3.39082633209044 2.77871996963658 0.612106362453859 0.994816701692805 1.13269509766287 0.551473381449831 0.6152956232161 0.540398173980657 0.142715876822799 NA NA NA 0.128887708594449 95.9503733227613 a1712 loss_cnaBRCA7_(FAS,PTEN) 1114 Cetuximab EGFR 4 41 4.18661983833127 NA 5.66798969662734 6.34254557791413 -0.674555881286786 1.16218091431804 0.836019345624366 0.781835244573433 0.580422439377791 0.80686635401123 0.142854533871141 NA NA NA 0.332700951398678 95.9503733227613 a1713 POLR2B_mut 205 BMS-708163 g-secretase 3 45 2.32630161961136 0.940007258491471 4.33990301867961 4.93363795088229 -0.593734932202681 0.762080328488571 0.663652859361271 0.888513701780908 0.779097570173779 0.894646838068502 0.143027876279269 NA NA NA 0.308038562481236 95.9503733227613 a1714 MLL3_mut 274 PXD101, Belinostat HDAC 3 45 2.99573227355399 NA -0.553808573955978 0.75319080729399 -1.30699938124997 0.890408493952406 1.49307750128546 0.887898595250653 1.46786490709266 0.875372765395442 0.143298457833309 NA NA NA 0.107575023001575 95.9503733227613 a1715 gain_cnaBRCA9_(KRAS) 295 NVP-BHG712 EPHB4 4 45 2.32630161961136 NA 4.74905137993909 3.81005552985144 0.938995850087653 0.743911914673285 1.23533302463918 0.776065646198186 1.26224063839607 0.76011555698668 0.143579885721613 NA NA NA 0.0773544226490902 95.9503733227613 a1716 gain_cnaBRCA10_(MDM2,NUP107) 201 Epothilone B Microtubules 4 44 -3.44201937618241 NA -2.97082470494004 -4.3507518538488 1.37992714890876 1.23995303993643 1.80747867512949 0.776984779478763 1.1128866210768 0.763454179513294 0.143623889106581 NA NA NA 0.106957585651275 95.9503733227613 a1717 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1026 17-AAG HSP90 5 38 0 NA 0.203564741948746 -1.04091341235409 1.24447815430283 1.78147888164374 1.75176425652554 0.709231499319562 0.698564640381578 0.710414172264901 0.143658049319653 NA NA NA 0.200367129003931 95.9503733227613 a1718 PTEN_mut 185 OSI-906 IGF1R 8 40 0.940007258491471 NA 3.42634928139415 2.78691803883718 0.639431242556966 0.42584324280772 1.1920226889011 0.576020467707664 1.50156484423938 0.536425395683068 0.143764403501264 NA NA NA 0.0123799067414308 95.9503733227613 a1719 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 172 Embelin XIAP 6 42 3.46573590279973 NA 2.45210430083422 3.07034187679123 -0.618237575957008 0.633272464570248 0.984389795364542 0.649057927594542 0.976258420420281 0.628041431217864 0.143790699298173 NA NA NA 0.0695611533009377 95.9503733227613 a1720 PTEN_mut 1046 681640 WEE1, CHEK1 4 32 0.693147180559945 NA 1.89787972960842 2.72578427785002 -0.827904548241597 1.0435822389093 1.04356000954265 0.793344881537775 0.793329473589819 0.793346372677157 0.143893397579571 NA NA NA 0.212813079912693 95.9503733227613 a1721 CDH1_mut 273 CUDC-101 HDAC, EGFR 4 45 1.63315443905142 NA -1.12586238770408 0.0710593888305713 -1.19692177653465 1.53123485180441 1.54536149261682 0.774975684570183 0.781670933837611 0.774525431268421 0.14413042287404 NA NA NA 0.217103815932639 95.9503733227613 a1722 gain_cnaBRCA31 262 VX-11e ERK 16 33 1.63315443905142 NA 4.17597027794953 3.58328063146594 0.592689646483597 0.976103648505356 1.4402903174448 0.45238735926498 0.607199499142478 0.41150706861314 0.14421791019022 NA NA NA 0.0977308943263847 95.9503733227613 a1723 CDH1_mut 253 XMD14-99 EPHB3, CAMK1 4 44 2.32630161961136 NA 4.39220918206269 4.98227390005573 -0.590064717993033 0.770012059806551 0.760306757750658 0.775438293752907 0.766305813627483 0.776087693523493 0.144404296309378 NA NA NA 0.224366269292447 95.9503733227613 a1724 CDH1_mut 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 4 44 2.32630161961136 NA 4.47193237158225 5.00272295183126 -0.530790580249016 0.78469211029013 0.677425553256426 0.774952044137049 0.676431651712114 0.783540829981204 0.144650366209509 NA NA NA 0.271492370504945 95.9503733227613 a1725 gain_cnaBRCA14_(RAD21) 1 Erlotinib EGFR 6 6 0.693147180559945 NA 2.6855489805342 3.16759620859232 -0.482047228058118 0.673119661469233 0.3223017304038 0.913459458250834 0.716138980409431 1.49563959043651 0.144695269637944 NA NA NA 0.15656785960897 95.9503733227613 a1726 PIK3CA_mut 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 10 16 2.30258509299405 NA 5.04575046565316 4.46081758684778 0.584932878805372 0.842275252368588 1.0284458329571 0.607495583305717 0.694467606830978 0.568754192064261 0.144858638193897 NA NA NA 0.128316160672309 95.9503733227613 a1727 gain_cnaBRCA15 63 BMS-509744 ITK 6 6 2.32630161961136 NA 3.13861550110989 4.05371520435725 -0.915099703247353 1.14371553319418 0.838214944129708 0.912663970068747 0.800111283521394 1.09172439558146 0.145009385758104 NA NA NA 0.147766687663958 95.9503733227613 a1728 loss_cnaBRCA38 1194 SB-505124 TGFR1 (ALK5) 3 44 2.30258509299405 NA 3.64061981967928 4.44002494853362 -0.799405128854334 0.848722978855194 0.905835994348786 0.884910181321957 0.941891699377124 0.882505369450498 0.145048244275672 NA NA NA 0.239486722215957 95.9503733227613 a1729 MACF1_mut 1219 PFI-1 BRD2, BRD3, BRD4 3 44 2.30258509299405 NA 2.35930028736529 3.22792520619186 -0.86862491882657 0.190518032420881 1.00370675612697 0.884573402438075 4.559279286003 0.865417028952119 0.145197753590008 NA NA NA 0.000357008511996876 95.9503733227613 a1730 gain_cnaBRCA12_(TERT) 300 CX-5461 RNA Pol I 9 40 2.32630161961136 NA 3.16229013741442 4.08113220328082 -0.918842065866398 1.76208171530261 1.66497180722342 0.54631286928578 0.521452585250055 0.551866441149356 0.14533460008107 NA NA NA 0.180144728383357 95.9503733227613 a1731 gain_cnaBRCA63 305 TPCA-1 IKK 7 42 2.99573227355399 NA 4.88295248617653 4.06088867890556 0.822063807270969 1.36070432072268 1.35976021304846 0.604511677075836 0.60414580504482 0.604565275099478 0.145347574073061 NA NA NA 0.176546959290491 95.9503733227613 a1732 loss_cnaBRCA18 1043 JNK Inhibitor VIII JNK 12 31 2.30258509299405 NA 5.06383084698968 4.6941700202165 0.369660826773177 0.574657029725512 0.78296351706771 0.504373488675899 0.643272086917212 0.472130333936375 0.145587092522423 NA NA NA 0.100529082721032 95.9503733227613 a1733 gain_cnaBRCA13_(FGFR1,WHSC1L1) 197 Bryostatin 1 PRKC 10 38 -4.8283137373023 NA -2.41061472049858 -2.91106423956214 0.500449519063562 0.952419687883278 0.951103919147167 0.526035078683885 0.525450623743189 0.526177538530493 0.14566812740208 NA NA NA 0.16115684595808 95.9503733227613 a1734 MLL3_mut 345 KIN001-270 CDK9 3 46 2.99573227355399 NA 4.54506884150317 5.14427295426406 -0.599204112760888 0.903392136080644 0.668112046332505 0.881461375946758 0.663282409519888 0.896861710621929 0.145742343970531 NA NA NA 0.369327998373623 95.9503733227613 a1735 ASH1L_mut 135 Gemcitabine DNA replication 3 44 0.0237165266173161 NA -2.52388293579654 -0.121906056594117 -2.40197687920242 1.50326747271687 2.76295835024794 0.883277414568742 1.597837326222 0.869349651610518 0.145774231526544 NA NA NA 0.0875309994922603 95.9503733227613 a1736 loss_cnaBRCA18 55 A-770041 SRC family 5 7 1.63315443905142 NA 3.30013672719037 2.2797975433433 1.02033918384707 1.07339515923898 1.12523635855675 0.923557866158888 0.950571814177426 0.906777652613159 0.145811180829418 NA NA NA 0.145958647624345 95.9503733227613 a1737 CDH1_mut 186 Bexarotene Retinioic acid X family agonist 4 43 2.07944154167984 NA 2.81078451105473 3.67823066698942 -0.867446155934694 1.11775576764825 1.12232832140885 0.773108334829768 0.776060550114447 0.772898749312318 0.146118277510813 NA NA NA 0.219848960559266 95.9503733227613 a1738 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1005 Cisplatin DNA crosslinker 6 39 1.79175946922805 2.30258509299405 4.32426011942271 3.56944100268822 0.754819116734486 1.15030322205562 1.16464270654442 0.64903631645856 0.656191430452227 0.648112174225593 0.146155110863976 NA NA NA 0.180874133973737 95.9503733227613 a1739 gain_cnaBRCA48 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 5 42 2.77258872223978 NA 5.64131160134962 4.93585265929372 0.705458942055905 0.503133902172771 1.04480867384139 0.699505779859983 1.40212961004893 0.675203948548958 0.14621227694887 NA NA NA 0.0314476773122608 95.9503733227613 a1740 MACF1_mut 1375 Temozolomide DNA akylating agent 3 43 3.40119738166216 NA 5.33318223831955 5.93968014684191 -0.606497908522363 0.351523470767933 0.698686364916297 0.883175326796283 1.72534114776865 0.868054593558616 0.146269281147172 NA NA NA 0.0712003975344891 95.9503733227613 a1741 PIK3CA_mut 1053 MK-2206 AKT1, AKT2 14 28 1.38629436111989 0.693147180559945 0.871616159309391 1.65501049961259 -0.783394340303196 1.38331445745303 1.7159704208676 0.484957150345895 0.566316889180491 0.456531377683719 0.146290526226393 NA NA NA 0.121096171478075 95.9503733227613 a1742 loss_cnaBRCA33 134 Etoposide TOP2 6 41 2.77258872223978 NA 1.279541196141 2.65235445312825 -1.37281325698725 2.27013870854374 2.10597155750267 0.646078778529647 0.604726597463239 0.651866950480174 0.146346506431703 NA NA NA 0.209750269910259 95.9503733227613 a1743 loss_cnaBRCA38 1003 Camptothecin TOP1 3 42 -2.30258509299405 NA -3.81818105216665 -2.43721718630531 -1.38096386586134 0.631469125734664 1.5936548746708 0.884043395099642 2.18690638953203 0.866538852175634 0.146352759118849 NA NA NA 0.0326703811104778 95.9503733227613 a1744 gain_cnaBRCA63 184 BMS-754807 IGF1R 6 42 0.940007258491471 NA 2.55913966774756 1.49368742424164 1.06545224350592 2.17020390268928 1.57788870340695 0.64471791210665 0.490945685880316 0.675239160534843 0.146427064054587 NA NA NA 0.291871860029947 95.9503733227613 a1745 loss_cnaBRCA57 275 I-BET BRD2, BRD3, BRD4 5 44 2.99573227355399 NA 4.87666252908439 3.94374543776899 0.9329170913154 1.61470975819209 1.31004055689689 0.696897393079855 0.577761474829966 0.712128404272624 0.146434703193296 NA NA NA 0.272186297173189 95.9503733227613 a1746 loss_cnaBRCA18 1373 Dabrafenib BRAF 15 31 2.30258509299405 NA 4.71860551193831 3.97071023779146 0.747895274146848 0.997121611486725 1.82515532341129 0.464933179043073 0.750054221602643 0.409770754605696 0.146473181851652 NA NA NA 0.0797689610887641 95.9503733227613 a1747 PIK3CA_mut 224 AS605240 PI3Kgamma 17 32 2.99573227355399 2.32630161961136 2.81977905036941 3.50957302689341 -0.689793976524008 1.10291737831594 1.74538493153281 0.443104317609074 0.625426700209643 0.395210227876912 0.1465026365366 NA NA NA 0.0980365439692531 95.9503733227613 a1748 gain_cnaBRCA64_(SDHC) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 9 37 0 NA -0.24207150654818 0.870987574278913 -1.11305908082709 3.25801890147147 1.6307530141191 0.549313679128076 0.341636778204198 0.682543016134389 0.146540778911691 NA NA NA 0.345722777302227 95.9503733227613 a1749 gain_cnaBRCA27_(CLTC,PPM1D) 1021 Axitinib PDGFR, KIT, VEGFR 10 35 0.693147180559945 NA 2.93684162726091 2.32678335586915 0.610058271391764 0.904189652306203 1.20792715099636 0.530021866984024 0.674701673300247 0.5050455823338 0.146653017737638 NA NA NA 0.0985245065091903 95.9503733227613 a1750 TP53_mut 1262 UNC1215 LMBL3 36 10 0 NA 2.82460637717207 2.51601046747089 0.308595909701178 0.542849055109515 0.723604359429466 0.52806686594053 0.568474618858684 0.426470495485259 0.146724492721181 NA NA NA 0.233750405922887 95.9503733227613 a1751 loss_cnaBRCA17 260 NG-25 MAP3K7 (TAK1) 11 38 2.32630161961136 NA 2.71254363568181 3.35186439043661 -0.639320754754799 0.967552511176354 1.33500779534745 0.505076040129155 0.660760782872147 0.478889154792096 0.146830474118948 NA NA NA 0.0922249550122461 95.9503733227613 a1752 loss_cnaBRCA33 291 KIN001-266 MAP3K8 (COT) 6 43 2.99573227355399 NA 3.12317266274346 3.87009418750386 -0.746921524760408 0.935830451545369 1.18613815387163 0.642747975677242 0.798137657870601 0.629708708317333 0.146916308997986 NA NA NA 0.117991824972577 95.9503733227613 a1753 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 15 28 -1.38629436111989 0.693147180559945 -1.93223136241166 -2.37494675078775 0.442715388376087 1.17633049723215 0.782725722850762 0.473023267255067 0.376352895226108 0.565607307197821 0.146960047741951 NA NA NA 0.204313364626625 95.9503733227613 a1754 BRCA2_mut 302 PI-103 PI3Ka, PRKDC (DNAPK) 6 42 2.32630161961136 NA 0.100402648406909 1.27529466097586 -1.17489201256895 1.70950241275148 1.83902539982827 0.643638174505235 0.687271339195092 0.638866658763201 0.14708885470898 NA NA NA 0.164307920259671 95.9503733227613 a1755 loss_cnaBRCA7_(FAS,PTEN) 151 QS11 ARFGAP 4 44 2.32630161961136 NA 4.78973717195108 3.66687832191964 1.12285885003144 0.867586525560936 1.49045332188346 0.770154608209616 1.29423269835301 0.75336733700087 0.147095964057096 NA NA NA 0.0720760208610017 95.9503733227613 a1756 gain_cnaBRCA31 1007 Docetaxel Microtubules 14 31 -4.38202663467388 NA -4.09016648154723 -4.81178237926002 0.721615897712786 1.95522977337434 1.28296693178897 0.475391509289435 0.369069613985788 0.56245868839859 0.147135649035519 NA NA NA 0.222300001764341 95.9503733227613 a1757 ASH1L_mut 274 PXD101, Belinostat HDAC 3 45 2.99573227355399 NA 1.88541854798311 0.590575665831384 1.29484288215173 1.08106912423314 1.4880243899941 0.879247914349343 1.19774291312799 0.870175845811816 0.147146947089685 NA NA NA 0.16220058574087 95.9503733227613 a1758 gain_cnaBRCA12_(TERT) 1066 AZD6482 PI3Kbeta 8 35 1.6094379124341 NA 1.30132878467357 2.11938394730661 -0.818055162633041 1.27970684238428 1.43959375751055 0.578712925648977 0.639252003301697 0.56825417473863 0.14738205328525 NA NA NA 0.13853886131481 95.9503733227613 a1759 gain_cnaBRCA15 91 KIN001-135 IKKE 6 8 1.6094379124341 NA 3.88530051610341 3.56704174327532 0.318258772828087 0.366087134919617 0.390577653013245 0.836279997216367 0.869352518760234 0.814841223948095 0.147462489649156 NA NA NA 0.145363957460253 95.9503733227613 a1760 BRCA1_mut 265 Tubastatin A HDAC6 4 45 2.99573227355399 NA 5.4111632900788 4.62781248916021 0.783350800918596 0.169874680366734 1.05271604479492 0.768391324019461 4.61134525302688 0.744123550497609 0.147491765319586 NA NA NA 0.000112364569578386 95.9503733227613 a1761 gain_cnaBRCA63 219 AT-7519 CDK9 7 42 2.32630161961136 NA 0.752692792572195 1.82521845516531 -1.07252566259312 2.38774986629792 1.6785739385611 0.600899754849013 0.449178399182998 0.63895050313512 0.147713333141559 NA NA NA 0.290777511564163 95.9503733227613 a1762 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 166 FTI-277 Farnesyl transferase (FNTA) 14 33 0.0237165266173161 NA 1.97974686991527 2.35665987512837 -0.3769130052131 1.01329720485482 0.698543304869544 0.469814972314516 0.371966885339531 0.53956999170365 0.147715269423577 NA NA NA 0.219976332380469 95.9503733227613 a1763 gain_cnaBRCA47_(EGFR) 226 GSK1070916 AURKB 7 42 0.940007258491471 2.32630161961136 1.41594517997244 2.56861479741539 -1.15266961744295 2.42891514986443 1.8320501818598 0.600782882202926 0.474561500226668 0.629169238297184 0.147790387484344 NA NA NA 0.268231614323803 95.9503733227613 a1764 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1149 TW 37 BCL2, BCL2L1 5 38 1.6094379124341 NA 0.617669301444679 -0.242391287538524 0.860060588983202 1.31270720282761 1.21574518382737 0.701779405276619 0.655180825648407 0.707434913519942 0.147804409370403 NA NA NA 0.224183315594553 95.9503733227613 a1765 TP53_mut 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 37 10 2.77258872223978 NA 5.1235427217767 4.59412889913463 0.529413822642062 0.945151175962746 1.23050172376237 0.524847698455213 0.560136659728315 0.430242243808753 0.147818863289948 NA NA NA 0.230350073816362 95.9503733227613 a1766 ASH1L_mut 197 Bryostatin 1 PRKC 3 45 -4.8283137373023 NA -3.58966708254165 -2.75461304579383 -0.835054036747821 0.920296403090823 0.95300621072274 0.877519463222492 0.907375095614071 0.876231473994838 0.147925592909155 NA NA NA 0.252544440607332 95.9503733227613 a1767 gain_cnaBRCA48 219 AT-7519 CDK9 5 44 2.32630161961136 NA 2.78454856496057 1.54557458727604 1.23897397768453 2.40182047185567 1.71630306235249 0.694132437960852 0.515847871313749 0.721885315514326 0.148007140948902 NA NA NA 0.318646298935396 95.9503733227613 a1768 PTEN_mut 197 Bryostatin 1 PRKC 8 40 -4.8283137373023 NA -3.25867288523197 -2.71643013066228 -0.542242754569688 1.08423218471379 0.92580816453022 0.569810739433394 0.500116822037364 0.585696665188556 0.148033261824956 NA NA NA 0.218412952932228 95.9503733227613 a1769 gain_cnaBRCA27_(CLTC,PPM1D) 269 NSC-207895 MDM4 9 40 2.99573227355399 NA 5.12171199665892 4.4874442401331 0.634267756525818 1.18752328485573 1.16660513912591 0.542020208806821 0.534109743037901 0.543686749915271 0.148451902191161 NA NA NA 0.172597799292174 95.9503733227613 a1770 gain_cnaBRCA27_(CLTC,PPM1D) 1495 AZD-2281 PARP1, PARP2 10 35 2.30258509299405 NA 4.45472665300154 3.86839548094211 0.58633117205943 1.04439942263744 1.12849617157427 0.527550828466847 0.561405109339068 0.519568596534527 0.148499375752277 NA NA NA 0.144312528444276 95.9503733227613 a1771 gain_cnaBRCA27_(CLTC,PPM1D) 1067 CCT007093 PPM1D 10 36 1.88706964903238 NA 3.68679458898785 4.19642556693915 -0.509630977951307 1.18845787979844 0.905259122005372 0.525427143965671 0.428817029710586 0.562966962235463 0.148706414982004 NA NA NA 0.232068988859031 95.9503733227613 a1772 gain_cnaBRCA62 1268 XAV 939 TNKS1 (tankyrase-1) 8 39 1.6094379124341 NA 4.0989786708763 3.57169171446329 0.527286956413016 1.61429625376883 0.729646516616235 0.57026856708817 0.326635805033916 0.722660828778201 0.148710802591057 NA NA NA 0.393214542411061 95.9503733227613 a1773 gain_cnaBRCA9_(KRAS) 1008 Methotrexate Dihydrofolate reductase (DHFR) 4 41 -1.6094379124341 NA -0.0695416228719198 0.75603463028467 -0.82557625315659 0.461965458763174 1.10406572264227 0.770253611948672 1.7870951983443 0.747760061947044 0.148720788376961 NA NA NA 0.0237935764048675 95.9503733227613 a1774 MLL3_mut 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 42 2.30258509299405 NA 4.22745409375767 3.10182504139435 1.12562905236332 1.16272772837022 1.28655149732302 0.878671646096632 0.968093410777347 0.874919546326336 0.148760751325253 NA NA NA 0.229819542556169 95.9503733227613 a1775 loss_cnaBRCA17 1047 Nutlin-3a MDM2 6 37 2.07944154167984 1.38629436111989 4.75734651385625 4.11769019846976 0.639656315386484 0.703692379294176 1.02120302910053 0.64745119657087 0.908999918441746 0.626375262468512 0.148891643505106 NA NA NA 0.0872555382329496 95.9503733227613 a1776 loss_cnaBRCA23 230 GSK429286A ROCK2 3 46 2.99573227355399 2.32630161961136 4.6801292840417 5.45281060570942 -0.772681321667724 0.957610643417353 0.880243226353569 0.874396890357941 0.806884642499705 0.877804336954204 0.14892616143877 NA NA NA 0.294999281076065 95.9503733227613 a1777 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 292 Masitinib KIT 7 41 2.99573227355399 NA 3.46018058904966 4.10425488252174 -0.644074293472086 1.11286774906674 1.06682981408572 0.600285398168544 0.578751872369571 0.60372730961223 0.148953143627485 NA NA NA 0.192362118881142 95.9503733227613 a1778 TP53_mut 312 AV-951 VEGFR 37 11 -2.05572501506252 NA 0.705267816726591 0.386757409556815 0.318510407169776 0.653697300941386 0.54610034027516 0.504078106314938 0.487244488712269 0.583245209130048 0.148956517289171 NA NA NA 0.121429055273437 95.9503733227613 a1779 loss_cnaBRCA18 104 Bortezomib Proteasome 6 8 -3.91202300542815 NA -3.78114322633613 -5.16489292920602 1.38374970286989 1.88841730382118 1.47897078429571 0.832641920608173 0.732756314014864 0.935616658262008 0.149081036077897 NA NA NA 0.170659684309727 95.9503733227613 a1780 ASH1L_mut 290 KIN001-260 IKK 3 46 2.99573227355399 NA 4.20187774654079 5.09899945382489 -0.897121707284099 0.884949471201088 1.03226407331483 0.874024590973148 1.01375472439855 0.869081594986877 0.149095457632249 NA NA NA 0.214631554218615 95.9503733227613 a1781 gain_cnaBRCA8_(CHD4,WNK1) 1203 QL-XII-61 BTK 3 20 2.30258509299405 NA 3.04875716811937 4.40167911856224 -1.35292195044287 1.82573312213552 1.41497713844477 0.927238543233276 0.741029416643537 0.956144034899312 0.149111736858737 NA NA NA 0.326771709323165 95.9503733227613 a1782 loss_cnaBRCA24 304 SB52334 ALK5 3 46 2.99573227355399 NA 3.27288468628352 4.36900090400792 -1.0961162177244 1.0598468796427 1.26240849359161 0.873778591832474 1.03422130005603 0.868273798290045 0.149207404312512 NA NA NA 0.208037599455002 95.9503733227613 a1783 loss_cnaBRCA42 265 Tubastatin A HDAC6 3 46 2.99573227355399 NA 3.85537579714103 4.7463062561109 -0.890930458969867 0.38597635379793 1.03889478542141 0.873749301138514 2.30825139986761 0.857575253502189 0.149220738021059 NA NA NA 0.0270776300163514 95.9503733227613 a1784 loss_cnaBRCA33 151 QS11 ARFGAP 6 42 2.32630161961136 NA 2.94362997402636 3.87713845257405 -0.933508478547689 1.58066687909314 1.44269315511606 0.640124735694746 0.59057888217615 0.647059615717516 0.149258662757228 NA NA NA 0.218595163679796 95.9503733227613 a1785 ARID1A_mut 1028 VX-702 p38 5 40 0.693147180559945 NA 3.01037622241627 3.47888833297842 -0.468512110562148 0.854186906509382 0.651199654656476 0.696495004588344 0.548488986417169 0.719460010784711 0.149289548231498 NA NA NA 0.293893301159127 95.9503733227613 a1786 gain_cnaBRCA61_(NOTCH2) 170 Shikonin unknown 3 44 2.77258872223978 NA 0.961038588886563 -0.061671350737665 1.02270993962423 0.432818215897759 1.1914594053069 0.875420110348542 2.36290872717292 0.858367423236542 0.149308154058722 NA NA NA 0.0241727168125669 95.9503733227613 a1787 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 110 Roscovitine CDKs 3 10 2.77258872223978 NA 4.83122021877125 3.85466509090769 0.976555127863556 0.56266054869291 1.0241710642549 1.02047571187032 1.73560262956439 0.953507828864524 0.149366252159218 NA NA NA 0.0736704396293368 95.9503733227613 a1788 gain_cnaBRCA16 224 AS605240 PI3Kgamma 16 33 2.99573227355399 2.32630161961136 2.801985807937 3.49729720575385 -0.695311397816853 1.06830009420297 1.73974043099892 0.446505453470833 0.650857752039802 0.399663872510926 0.14938806763701 NA NA NA 0.0920764162868664 95.9503733227613 a1789 loss_cnaBRCA24 1199 Tamoxifen ER 3 44 1.6094379124341 NA 4.63797091175886 3.81675199346614 0.821218918292718 0.327843444186783 0.95729878435888 0.875189573796809 2.50491181951116 0.857850163094799 0.149412852527179 NA NA NA 0.0186877682325316 95.9503733227613 a1790 gain_cnaBRCA27_(CLTC,PPM1D) 173 FH535 unknown 9 39 3.46573590279973 NA 1.01770315678037 1.70114305021655 -0.683439893436184 1.01302039267134 1.30693157065156 0.542090750845709 0.674655612444239 0.522934718835708 0.149477838202204 NA NA NA 0.106110535587011 95.9503733227613 a1791 gain_cnaBRCA31 261 TL-1-85 MAP3K7 (TAK1) 16 33 2.32630161961136 NA 4.38365694054828 3.85081835704303 0.532838583505252 1.32201430254958 1.12898097194303 0.44626988960047 0.403050543763136 0.471964184292858 0.149598129109951 NA NA NA 0.177622437653823 95.9503733227613 a1792 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1047 Nutlin-3a MDM2 8 35 2.07944154167984 1.38629436111989 3.74419945446455 4.31271487973721 -0.568515425272659 0.852323772043554 1.01374833428801 0.575387405306171 0.667018149581315 0.560805286720345 0.149662385062276 NA NA NA 0.126935146952926 95.9503733227613 a1793 loss_cnaBRCA33 1009 ATRA Retinoic acid and retinoid X receptor agonist 5 40 2.30258509299405 NA 3.40178928656557 4.19399356971335 -0.792204283147774 0.930069276288314 1.15788702322509 0.69575876621687 0.851769113704383 0.684180984204513 0.149709679975113 NA NA NA 0.134721323649066 95.9503733227613 a1794 NF1_mut 344 THZ-2-49 CDK9 5 44 2.99573227355399 NA 2.68604186366811 1.68291512397834 1.00312673968976 1.87675373735111 1.40603237677054 0.690836350226646 0.534500994843149 0.713444979121892 0.149898998546902 NA NA NA 0.30401512993158 95.9503733227613 a1795 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 178 BAY 61-3606 SYK 9 39 2.07944154167984 NA 3.79188599149566 2.93510670554451 0.856779285951152 1.32321621522383 1.631571159641 0.541488506522751 0.647497571518364 0.525125294651366 0.149920352756742 NA NA NA 0.11650027398661 95.9503733227613 a1796 gain_cnaBRCA48 1377 Afatinib (rescreen) ERBB2, EGFR 5 42 2.30258509299405 NA 4.04675382772229 2.69034088027418 1.35641294744811 0.835129158362639 2.03400549056924 0.692965838905825 1.62419541200969 0.666867888871091 0.149932864526101 NA NA NA 0.0177479936913129 95.9503733227613 a1797 gain_cnaBRCA58_(CCND1) 287 KIN001-244 PDPK1 (PDK1) 10 39 2.99573227355399 NA 3.86165125146293 3.37976111631725 0.48189013514568 0.862118774737367 0.943946587757044 0.518810988480852 0.558960260774371 0.510505722882819 0.149940340357703 NA NA NA 0.142902402508576 95.9503733227613 a1798 loss_cnaBRCA7_(FAS,PTEN) 205 BMS-708163 g-secretase 4 44 2.32630161961136 0.940007258491471 4.42782200062159 4.93913929189217 -0.511317291270586 0.514949139857996 0.678198587617241 0.76456636943091 0.99294717030033 0.753934467877661 0.149985733304981 NA NA NA 0.138433984407338 95.9503733227613 a1799 gain_cnaBRCA27_(CLTC,PPM1D) 193 GW-2580 CSF1R (cFMS) 9 39 2.99573227355399 NA 5.14041828246092 5.53792054100488 -0.397502258543956 1.03746205884596 0.653080748074735 0.54116990946558 0.383148718697361 0.608657137292414 0.150154867204041 NA NA NA 0.298287820847179 95.9503733227613 a1800 ASH1L_mut 344 THZ-2-49 CDK9 3 46 2.99573227355399 NA 2.97338209001178 1.70778975007288 1.2655923399389 2.75834401987196 1.36533835251713 0.87156143815783 0.45882323989364 0.92694410700883 0.150219352952666 NA NA NA 0.510815139077213 95.9503733227613 a1801 gain_cnaBRCA16 255 CP724714 ERBB2 16 32 2.32630161961136 NA 3.31239268212611 4.04835718676633 -0.735964504640219 2.2497003549809 1.24857832403047 0.447813232194219 0.327138902303488 0.589442000133791 0.150389251215603 NA NA NA 0.237534415610917 95.9503733227613 a1802 ARID1A_mut 282 EKB-569 EGFR 5 42 0.916290731874155 2.99573227355399 0.289693843136722 1.73144526264691 -1.44175141951019 2.80858299751218 1.99849565333505 0.69205231458876 0.51333765845171 0.721418341393048 0.150458460863547 NA NA NA 0.320979751294269 95.9503733227613 a1803 gain_cnaBRCA27_(CLTC,PPM1D) 344 THZ-2-49 CDK9 9 40 2.99573227355399 NA 2.42444666695515 1.64146136926978 0.782985297685364 1.16438552987286 1.50438751865445 0.539191248589728 0.672445060160494 0.520467823600185 0.150534926435072 NA NA NA 0.10638629642994 95.9503733227613 a1804 BRCA1_mut 302 PI-103 PI3Ka, PRKDC (DNAPK) 4 44 2.32630161961136 NA 2.40642747239519 1.01225185822379 1.3941756141714 1.4517361225951 1.84939918243885 0.763469072833474 0.960350570928271 0.753853266190412 0.1505583821753 NA NA NA 0.14844449179257 95.9503733227613 a1805 NF1_mut 254 AC220 FLT3 4 44 0.0237165266173161 NA 1.61508194036013 2.27909643873252 -0.664014498372387 1.09260247803815 0.852291784219644 0.763243870227356 0.607736584640259 0.77909292412147 0.150676121849822 NA NA NA 0.314050899446279 95.9503733227613 a1806 gain_cnaBRCA62 255 CP724714 ERBB2 10 38 2.32630161961136 NA 3.12728819951042 3.98086397093253 -0.853575771422109 2.04790107621957 1.52907926063464 0.519356415407506 0.416805177424787 0.558228597690766 0.150733441310785 NA NA NA 0.242402234354929 95.9503733227613 a1807 gain_cnaBRCA31 1003 Camptothecin TOP1 14 31 -2.30258509299405 NA -2.02207184230657 -2.75834384480745 0.736272002500883 1.57006273054482 1.55982871059791 0.471084504298103 0.468944321890496 0.472021060709069 0.150745346353441 NA NA NA 0.156930067880441 95.9503733227613 a1808 loss_cnaBRCA29_(MAP2K4) 186 Bexarotene Retinioic acid X family agonist 7 40 2.07944154167984 NA 3.03220771754669 3.70454006754843 -0.67233235000174 0.963044853015433 1.14520429362525 0.598892851251438 0.698131917632466 0.587085076212393 0.150752760855358 NA NA NA 0.131651782507706 95.9503733227613 a1809 loss_cnaBRCA36_(FAT1,IRF2) 1032 Afatinib ERBB2, EGFR 8 37 -0.693147180559945 NA 1.13547503193106 0.107768274927913 1.02770675700315 1.20561887841644 1.89676235639262 0.570187298334477 0.852430876292373 0.541821569549548 0.150910856634834 NA NA NA 0.0698766271134278 95.9503733227613 a1810 loss_cnaBRCA33 135 Gemcitabine DNA replication 6 41 0.0237165266173161 NA -1.79122772442188 -0.0533694866097432 -1.73785823781214 2.72100147708417 2.72101007634827 0.638681518734772 0.638683312908169 0.63868129446416 0.150914732294172 NA NA NA 0.190195264817325 95.9503733227613 a1811 TP53_mut 11 Paclitaxel Microtubules 9 3 -2.27886856637673 NA -2.66419284126479 -4.38423841512754 1.72004557386276 1.75338697348492 1.21012316048547 1.03677940962151 0.98098457435446 1.42138059168517 0.150958845769042 NA NA NA 0.115943030144227 95.9503733227613 a1812 loss_cnaBRCA29_(MAP2K4) 1259 BMN-673 PARP1 7 39 2.30258509299405 NA 4.08449820614817 3.16572467743093 0.918773528717236 1.09463769379909 1.59077521659334 0.599484145186839 0.839340298549843 0.577563391190364 0.15127673474491 NA NA NA 0.0848572009578592 95.9503733227613 a1813 loss_cnaBRCA17 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 9 37 2.30258509299405 NA 1.84078877166313 1.30916073400414 0.531628037658989 0.635311896620165 1.04074714260893 0.542702796251971 0.836798492972081 0.510813833537235 0.151345576111384 NA NA NA 0.0650192336291083 95.9503733227613 a1814 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 127 GSK269962A ROCK1, ROCK2 3 11 0.916290731874155 NA 3.28525076953746 2.245208653481 1.04004211605646 0.377591141901655 1.12897705499996 0.998049258146297 2.75441343994066 0.921225202452407 0.151377156441655 NA NA NA 0.0262505614393691 95.9503733227613 a1815 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 279 BIX02189 MAP2K5 (MEK5) 7 42 2.99573227355399 NA 5.47984430331451 4.95194133475036 0.527902968564146 1.00573169290252 0.868089073052434 0.595255691175393 0.524894434857302 0.608120738932813 0.151470802894142 NA NA NA 0.22863395447518 95.9503733227613 a1816 gain_cnaBRCA58_(CCND1) 194 AUY922 HSP90 9 38 -1.36257783450257 NA -1.64996222364753 -2.56990664482575 0.919944421178218 1.52067747020788 1.73777377446043 0.540760506674377 0.604956961092125 0.529381001542538 0.15158995782556 NA NA NA 0.135965727806696 95.9503733227613 a1817 gain_cnaBRCA47_(EGFR) 184 BMS-754807 IGF1R 7 41 0.940007258491471 NA 0.784701302007162 1.7706536758679 -0.985952373860739 1.52548257762096 1.67192078658624 0.596261942140748 0.64632162197379 0.589712372602219 0.151634717232491 NA NA NA 0.155050697804251 95.9503733227613 a1818 gain_cnaBRCA31 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 14 31 2.30258509299405 NA 1.01411595814403 1.52393410567321 -0.509818147529187 1.0287615981248 1.10804208922634 0.470014993027342 0.495564908778157 0.460107203946695 0.151652447264197 NA NA NA 0.144697137681334 95.9503733227613 a1819 gain_cnaBRCA30_(CRNKL1,FOXA2) 333 T0901317 LXR 5 43 2.32630161961136 NA 5.20001769171223 4.68141510304336 0.518602588668871 1.01584977734932 0.723097403624032 0.688637071123656 0.510511101377678 0.717196032055611 0.151789937240593 NA NA NA 0.323213913556994 95.9503733227613 a1820 loss_cnaBRCA29_(MAP2K4) 238 CAL-101 PI3Kdelta 7 42 2.99573227355399 2.32630161961136 5.19389712973117 4.63980873438216 0.554088395349007 0.667541303697424 0.964291288626964 0.594715739174746 0.830043612702291 0.574606866082927 0.151834173701714 NA NA NA 0.0858715217039741 95.9503733227613 a1821 loss_cnaBRCA33 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 5 41 2.30258509299405 NA 0.810003127140266 1.48673245042488 -0.676729323284617 1.79737504789055 0.855940578973344 0.690785380685883 0.376509801935241 0.790626522341444 0.151864817507492 NA NA NA 0.450627529404079 95.9503733227613 a1822 gain_cnaBRCA64_(SDHC) 1059 AZD8055 MTORC1/2 7 36 0.693147180559945 NA 0.630777329038429 0.0331411178791648 0.597636211159264 0.95223168180079 0.99732306739055 0.603153552084549 0.627616390613111 0.599240337158702 0.151872931231904 NA NA NA 0.166848208088257 95.9503733227613 a1823 gain_cnaBRCA63 185 OSI-906 IGF1R 6 42 0.940007258491471 NA 3.51158116803118 2.80519116182032 0.706390006210862 1.09438475261195 1.11314701539842 0.635744211212952 0.645467697283734 0.634588240761735 0.151999207884011 NA NA NA 0.18625557569389 95.9503733227613 a1824 gain_cnaBRCA27_(CLTC,PPM1D) 1494 SN-38 TOP1 10 38 -2.99573227355399 NA -2.62406122788484 -3.4826641104601 0.858602882575265 2.64996669799639 1.30821525718151 0.517708491095849 0.324005159470285 0.656316212383185 0.152004371831338 NA NA NA 0.343612536449942 95.9503733227613 a1825 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 194 AUY922 HSP90 6 41 -1.36257783450257 NA -3.33891882020968 -2.25542925841337 -1.08348956179631 0.900288269169441 1.77620018354968 0.636861984902647 1.20349181356754 0.610004194251906 0.152055437530082 NA NA NA 0.0367780363414064 95.9503733227613 a1826 gain_cnaBRCA15 1264 SGC0946 Q8TEK3 (DOT1L) 21 25 -0.693147180559945 NA 2.09076313647691 1.83307210587024 0.257691030606668 0.554924593259691 0.630831564571756 0.431264019668392 0.464371256449388 0.408494192552973 0.152230852523178 NA NA NA 0.147736713974751 95.9503733227613 a1827 BRCA1_mut 262 VX-11e ERK 4 45 1.63315443905142 NA 4.69120883748823 3.69553222079146 0.995676616696774 0.166833928973509 1.35456794879591 0.759303898321295 5.96807030094505 0.735051067450578 0.152232147334538 NA NA NA 4.37569360043763e-05 95.9503733227613 a1828 loss_cnaBRCA57 222 BX-912 PDPK1 (PDK1) 5 44 2.32630161961136 NA 4.80251470212217 3.77937919779568 1.02313550432649 0.619756659727661 1.54602483269331 0.686766912620783 1.65086649456269 0.661784650990434 0.152260938625379 NA NA NA 0.0163285289000097 95.9503733227613 a1829 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 5 21 2.30258509299405 NA 5.25889134720795 4.54933949095506 0.709551856252888 0.899524821834538 0.976884810784916 0.735727188933165 0.788807422574278 0.726341374560601 0.152276456246853 NA NA NA 0.166617205102273 95.9503733227613 a1830 TP53_mut 127 GSK269962A ROCK1, ROCK2 9 5 0.916290731874155 NA 2.78550692302013 1.89669703794445 0.888809885075678 0.690856671820007 1.51848934949793 0.852581046699128 1.28653296889235 0.585325070188705 0.152299254182671 NA NA NA 0.270790713703604 95.9503733227613 a1831 PIK3CA_mut 1013 Nilotinib ABL 14 26 0.693147180559945 NA 3.49888472134396 3.04353496913104 0.455349752212915 0.837323882060296 0.989813465846455 0.484191783935032 0.543815555687357 0.460035923863205 0.152338490046806 NA NA NA 0.134472827677888 95.9503733227613 a1832 gain_cnaBRCA64_(SDHC) 1199 Tamoxifen ER 9 38 1.6094379124341 NA 4.2787155272633 3.77217265006361 0.506542877199684 1.04458213510712 0.914135835292904 0.539649187633403 0.484923932906186 0.554122109256749 0.152413645014052 NA NA NA 0.207554046570459 95.9503733227613 a1833 PIK3CA_mut 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 16 32 0.246860077931526 2.32630161961136 0.218693076593644 -0.506774345341887 0.725467421935531 1.49458550486171 1.69003026573128 0.445378874321537 0.485397068000238 0.429262976318131 0.152569760723515 NA NA NA 0.138745681637854 95.9503733227613 a1834 gain_cnaBRCA13_(FGFR1,WHSC1L1) 255 CP724714 ERBB2 11 37 2.32630161961136 NA 4.4358773913596 3.61489355636715 0.820983834992449 0.777062653116687 1.81252468829172 0.49941954668956 1.05652205996466 0.452950428921448 0.152663863391421 NA NA NA 0.036389703041041 95.9503733227613 a1835 gain_cnaBRCA63 153 Midostaurin KIT 6 41 -0.669430653942629 NA 1.40734451415156 0.495819120705869 0.911525393445688 1.37314478205395 1.440884842244 0.63586680075317 0.663823221963694 0.632615020105356 0.152682204229746 NA NA NA 0.176802450191341 95.9503733227613 a1836 ASH1L_mut 263 FR-180204 ERK 3 46 2.99573227355399 NA 4.77059772968645 5.39618622587081 -0.625588496184357 0.565374200958278 0.72873320044573 0.865825041195904 1.10650343635069 0.858460264746708 0.152862617925584 NA NA NA 0.186261793650783 95.9503733227613 a1837 gain_cnaBRCA47_(EGFR) 262 VX-11e ERK 7 42 1.63315443905142 NA 3.11003907741986 3.8879407558007 -0.777901678380842 1.58614785401531 1.26619161372867 0.59318820620269 0.490434530684889 0.614363315904523 0.152865866775789 NA NA NA 0.255402626992587 95.9503733227613 a1838 loss_cnaBRCA29_(MAP2K4) 1143 HG-5-88-01 EGFR, ADCK4 3 23 2.30258509299405 NA 5.29572641384491 4.43473147780542 0.860994936039487 0.310819733444456 0.988218664553784 0.905936353341901 2.77007809799614 0.871259536904473 0.152990725804435 NA NA NA 0.0112816607730189 95.9503733227613 a1839 loss_cnaBRCA57 1091 BMS-536924 IGF1R 5 42 1.38629436111989 NA 3.68571618807265 2.94444341337565 0.741272774697001 0.502864325918019 1.1183261636144 0.687673247189676 1.47410093834703 0.662841305886316 0.152998143028586 NA NA NA 0.0262893227586459 95.9503733227613 a1840 gain_cnaBRCA63 1005 Cisplatin DNA crosslinker 6 39 1.79175946922805 2.30258509299405 4.31360099977466 3.57108086724946 0.742520132525199 1.66506606085256 1.08084329376945 0.637935969109791 0.445940344339858 0.686982226568346 0.153008857993963 NA NA NA 0.332828551163041 95.9503733227613 a1841 PIK3CA_mut 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 16 27 1.6094379124341 NA 3.372729616457 2.69297443799736 0.679755178459646 1.25603252050742 1.59555836841591 0.459169213851716 0.541192339657762 0.426029653264592 0.153174993392265 NA NA NA 0.130066688936433 95.9503733227613 a1842 loss_cnaBRCA18 221 TAK-715 p38a 16 33 2.99573227355399 2.32630161961136 4.18664605439757 4.62542867001588 -0.438782615618313 0.665519355004513 1.1126752552978 0.442272365152109 0.659308572047973 0.394349216924822 0.153198450396317 NA NA NA 0.0926380086013523 95.9503733227613 a1843 gain_cnaBRCA15 1007 Docetaxel Microtubules 21 24 -4.38202663467388 NA -4.23531402982233 -4.89524957801888 0.659935548196549 1.72352577829202 1.31565303539257 0.434440843291629 0.38289856555005 0.501603029403293 0.153229714726292 NA NA NA 0.161640446171098 95.9503733227613 a1844 BRCA2_mut 207 AS601245 JNK 6 42 2.07944154167984 NA 1.56510827759962 2.36635677537205 -0.80124849777243 0.973940078711322 1.29553457095681 0.633625097541248 0.822687673796739 0.618469406941932 0.153339094631978 NA NA NA 0.110507398235004 95.9503733227613 a1845 gain_cnaBRCA47_(EGFR) 1069 EHT 1864 Rac GTPases 7 39 2.30258509299405 NA 3.98895062137194 3.48468573118667 0.504264890185275 0.85479819656462 0.844056544967593 0.596389574746696 0.589922735227898 0.597430223356228 0.153349546506635 NA NA NA 0.186774617399699 95.9503733227613 a1846 PIK3CA_mut 1243 piperlongumine Increases ROS levels 16 31 2.30258509299405 NA 1.46235441583321 1.83819182137281 -0.375837405539594 0.842174566836414 0.839958759846517 0.447053996304646 0.446270191881249 0.447447450406101 0.153359708524734 NA NA NA 0.157025904637752 95.9503733227613 a1847 POLR2B_mut 257 NPK76-II-72-1 PLK3 3 46 2.32630161961136 NA 4.7466827360364 3.39628274670098 1.35039998933542 0.57879766637602 1.5915552841125 0.864591019453203 2.33311235995572 0.848478216757918 0.153435986803944 NA NA NA 0.0256920885390081 95.9503733227613 a1848 gain_cnaBRCA62 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 10 38 0.246860077931526 2.32630161961136 -0.930214777663592 -0.089882685494899 -0.840332092168693 1.77899084406634 1.59042118924095 0.515846960196424 0.47236448403967 0.528370784955245 0.15345016167672 NA NA NA 0.1975623947064 95.9503733227613 a1849 loss_cnaBRCA33 150 Bicalutamide ANDR (androgen receptor) 6 42 0.0237165266173161 NA 2.42214338275173 2.81122265212427 -0.389079269372544 0.549263798056762 0.621741682182184 0.633392777159784 0.708365034704755 0.625789263487943 0.153486550222175 NA NA NA 0.15487067460896 95.9503733227613 a1850 PIK3CA_mut 290 KIN001-260 IKK 17 32 2.99573227355399 NA 5.33603915786689 4.88896695099469 0.447072206872202 0.854112090113802 1.10559302785183 0.435352546188929 0.523435052666956 0.404373214745088 0.153537644013245 NA NA NA 0.124232758592889 95.9503733227613 a1851 gain_cnaBRCA58_(CCND1) 1527 GDC0941 (rescreen) PI3K 9 36 1.38629436111989 NA 0.487785801200025 1.10387335140451 -0.616087550204487 0.531255145400959 1.2354335765098 0.541419616879527 1.15968298008578 0.498681241888361 0.153543459331141 NA NA NA 0.0303601056424955 95.9503733227613 a1852 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1375 Temozolomide DNA akylating agent 6 40 3.40119738166216 NA 6.27995640167672 5.84315136547751 0.436805036199204 0.844063676212663 0.66455749926921 0.635518235658679 0.517502468722692 0.657287046913988 0.153699015175563 NA NA NA 0.271136525718786 95.9503733227613 a1853 PTEN_mut 1006 Cytarabine DNA synthesis 7 38 0.693147180559945 NA 0.450137640389541 1.34823773376321 -0.898100093373672 1.21316873363348 1.54647949759792 0.596977969849939 0.740292812100289 0.58073844158209 0.153920351614336 NA NA NA 0.116543211834403 95.9503733227613 a1854 loss_cnaBRCA23 1114 Cetuximab EGFR 3 42 4.18661983833127 NA 6.98192116352494 6.23263247596223 0.749288687562712 0.321783439464994 0.881909511834284 0.867284951547458 2.32854956367083 0.849620825615392 0.153968524805505 NA NA NA 0.0250641468304214 95.9503733227613 a1855 CDH1_mut 1010 Gefitinib EGFR 4 41 -0.693147180559945 NA 2.11003167178512 1.33061646276587 0.779415209019251 0.774110090525592 1.04172396665506 0.760166039338429 1.00685318349236 0.748197443821825 0.15398398162487 NA NA NA 0.134483561242334 95.9503733227613 a1856 NF1_mut 153 Midostaurin KIT 4 43 -0.669430653942629 NA -0.381821799373323 0.704649726310308 -1.08647152568363 1.17922998493096 1.45021234417799 0.757787783187944 0.921339806116992 0.749180994111221 0.154090440114327 NA NA NA 0.161427039912677 95.9503733227613 a1857 ASH1L_mut 298 OSI-930 KIT, VEGFR, PDGFR 3 45 2.32630161961136 NA 3.21585543476912 3.95986808722043 -0.74401265245131 0.399994433925278 0.876279014260619 0.864059287667725 1.86005751417605 0.849059078607615 0.154100959040726 NA NA NA 0.0572243753771822 95.9503733227613 a1858 PIK3CA_mut 1030 KU-55933 ATM 15 27 2.30258509299405 NA 4.49491019181282 4.07084889017848 0.424061301634332 0.881340128812974 0.920123158361961 0.467677973928157 0.481155104335798 0.460874501180105 0.154223871298567 NA NA NA 0.151738588673727 95.9503733227613 a1859 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 166 FTI-277 Farnesyl transferase (FNTA) 5 42 0.0237165266173161 NA 1.75271886562813 2.30291994595022 -0.550201080322088 0.432246065763893 0.830212376001279 0.685296498838825 1.27288857875372 0.662723293733747 0.154390605895516 NA NA NA 0.0445759205638856 95.9503733227613 a1860 CDH1_mut 163 JQ1 BRD4 4 43 0.940007258491471 NA -0.679206966763814 0.408486392151568 -1.08769335891538 1.19846548538747 1.45194361252463 0.757216020272324 0.907571700793475 0.749129201391028 0.154394449897557 NA NA NA 0.166247991533075 95.9503733227613 a1861 gain_cnaBRCA63 1192 GSK269962A ROCK1, ROCK2 6 40 1.6094379124341 NA 3.46270382939597 2.54872960941881 0.913974219977157 1.67189323363405 1.40901528956437 0.634129883117933 0.546670206918973 0.648661676524271 0.154579169983421 NA NA NA 0.249294629719839 95.9503733227613 a1862 gain_cnaBRCA63 206 Ruxolitinib JAK1, JAK2, TYK2 7 42 1.65632149833295 0.0237165266173161 4.696287318688 4.31592264127139 0.38036467741661 0.881914859382682 0.601451858934285 0.590544031452042 0.431294102111916 0.632410843472294 0.154664739569598 NA NA NA 0.308207001299273 95.9503733227613 a1863 ARID1A_mut 299 OSI-027 MTORC1/2 5 43 2.99573227355399 NA 0.0712657803131378 1.40823744541152 -1.33697166509839 2.27182176903286 1.92317272241496 0.683537794291653 0.588502004568584 0.695190634473814 0.154777409352407 NA NA NA 0.265290937893221 95.9503733227613 a1864 loss_cnaBRCA60 1170 CCT018159 HSP90 3 40 2.30258509299405 NA 4.2884612322164 3.2719059486097 1.0165552836067 0.768646538120466 1.18873627999121 0.867557838884425 1.32252632802125 0.855156270332911 0.154863286618086 NA NA NA 0.132684333561016 95.9503733227613 a1865 gain_cnaBRCA16 1377 Afatinib (rescreen) ERBB2, EGFR 16 31 2.30258509299405 NA 2.25931689526071 3.13158115438566 -0.872264259124947 2.39080594196609 1.70162735902879 0.445376387410808 0.364841095554429 0.51260592073625 0.154873471719317 NA NA NA 0.206652262125449 95.9503733227613 a1866 gain_cnaBRCA10_(MDM2,NUP107) 1129 PF-4708671 RPS6KB1 (p70S6KA) 3 40 2.30258509299405 NA 4.7176106410906 3.74081864451566 0.976791996574943 0.863032204454149 1.13803817679652 0.867347990297081 1.13181407545822 0.858312151991711 0.154960675185133 NA NA NA 0.178282749647461 95.9503733227613 a1867 gain_cnaBRCA12_(TERT) 294 MPS-1-IN-1 MPS1 9 40 2.99573227355399 NA 4.25346731563178 4.86970404010173 -0.616236724469954 0.904166552944122 1.2007735685568 0.533226300748271 0.681552223385594 0.513199774384278 0.155002360121452 NA NA NA 0.103981310944136 95.9503733227613 a1868 gain_cnaBRCA27_(CLTC,PPM1D) 163 JQ1 BRD4 9 38 0.940007258491471 NA -0.306668569718862 0.463371161129787 -0.770039730848649 1.1301845090699 1.49455888806816 0.536033332424819 0.681339838467933 0.515228765488115 0.155118022288701 NA NA NA 0.105642099501804 95.9503733227613 a1869 gain_cnaBRCA16 88 MS-275 HDAC 3 11 1.6094379124341 NA -0.161822422921771 1.49398908953968 -1.65581151246145 0.397088330112035 1.82707730514513 0.988104445866296 4.16988208138546 0.906262426772315 0.155151452213267 NA NA NA 0.0168406376281599 95.9503733227613 a1870 loss_cnaBRCA36_(FAT1,IRF2) 91 KIN001-135 IKKE 3 11 1.6094379124341 NA 3.99979757004968 3.62261312115218 0.377184448897507 0.292043024375133 0.39740484653179 0.98773336657179 1.29153726477305 0.949118895225489 0.155293832851849 NA NA NA 0.137128643703694 95.9503733227613 a1871 gain_cnaBRCA58_(CCND1) 178 BAY 61-3606 SYK 9 39 2.07944154167984 NA 3.78294294852757 2.93717048469099 0.845772463836579 1.2462699361727 1.64537359530976 0.534214406908586 0.678643076662791 0.514030653127961 0.155347038795421 NA NA NA 0.105835689342396 95.9503733227613 a1872 gain_cnaBRCA31 238 CAL-101 PI3Kdelta 16 33 2.99573227355399 2.32630161961136 4.99503104210351 4.58511363874282 0.409917403360693 0.794614534620183 0.989919502931766 0.439804233066482 0.515869500872683 0.414091653055297 0.155455086780958 NA NA NA 0.127709800159611 95.9503733227613 a1873 TP53_mut 158 PF-562271 FAK 36 9 0.940007258491471 NA 2.46999360321271 1.78627661491782 0.68371698829489 1.30989309458498 1.0710926316979 0.538838197837701 0.521963961121207 0.638336002004851 0.155467669278484 NA NA NA 0.123630269719912 95.9503733227613 a1874 loss_cnaBRCA18 119 Lapatinib ERBB2, EGFR 5 8 0.693147180559945 NA 2.57143572989846 0.736479253886688 1.83495647601177 0.875587259772032 2.56214763194072 0.869242001781984 2.09568658695367 0.716179057419056 0.155543097251871 NA NA NA 0.0948702103830917 95.9503733227613 a1875 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 94 TGX221 PI3Kbeta 4 10 2.30258509299405 NA 4.54149917946626 3.46023613477032 1.08126304469594 1.11071000561167 1.23639983836432 0.896416666613408 0.97348816453714 0.874525385029477 0.155605435382592 NA NA NA 0.160874796224203 95.9503733227613 a1876 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1033 Vismodegib SMO 6 39 2.30258509299405 NA 5.18273300102727 4.69470404178259 0.488028959244676 0.661961746492634 0.783398662295992 0.633587938071229 0.73724646753452 0.622963738301973 0.155761510183591 NA NA NA 0.143431809213754 95.9503733227613 a1877 loss_cnaBRCA18 230 GSK429286A ROCK2 16 33 2.99573227355399 2.32630161961136 5.14379611277886 5.53239205788778 -0.388595945108928 0.692713066139932 0.961083465982296 0.439425821690511 0.560976779713911 0.404331110526135 0.155803363003842 NA NA NA 0.114466187998092 95.9503733227613 a1878 gain_cnaBRCA14_(RAD21) 38 AZD-0530 SRC, ABL1 6 8 0.693147180559945 NA 2.29804377654074 2.80280964004566 -0.504765863504927 0.478130482665209 0.699782189508105 0.817860595477151 1.05570734727317 0.721318534642529 0.155815217228298 NA NA NA 0.135313685645913 95.9503733227613 a1879 PIK3CA_mut 171 AKT inhibitor VIII AKT1, AKT2, AKT3 16 31 0.940007258491471 NA 1.52682614171738 2.07541099084498 -0.548584849127597 1.37476281431349 1.15847923280299 0.444273704400604 0.399039633175954 0.47353878567186 0.155874831460511 NA NA NA 0.183705900848631 95.9503733227613 a1880 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1005 Cisplatin DNA crosslinker 7 38 1.79175946922805 2.30258509299405 4.25419052620468 3.56248489836695 0.691705627837733 1.09240480491392 1.17557711368974 0.594081212104199 0.633195336313296 0.588396643472161 0.155880758189491 NA NA NA 0.163495489974406 95.9503733227613 a1881 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1133 JNJ-26854165 MDM2 5 38 2.30258509299405 NA 3.49030329123145 2.90019900316555 0.590104288065905 0.842167069945294 0.859880433052724 0.68763227740526 0.700697413999145 0.686263188907478 0.155936218241028 NA NA NA 0.199916603400522 95.9503733227613 a1882 gain_cnaBRCA31 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 14 32 2.30258509299405 NA 1.72849401660041 1.27522280845987 0.453271208140542 0.779660608279342 1.05288007170428 0.462467096879052 0.581369897782678 0.430506018987366 0.156032882156035 NA NA NA 0.114201907636043 95.9503733227613 a1883 gain_cnaBRCA8_(CHD4,WNK1) 329 QL-XI-92 DDR1 4 44 2.32630161961136 NA 3.60939505637997 4.31187510199381 -0.702480045613836 1.55412595749266 0.873328142736626 0.752929700326412 0.452009724325806 0.804371245168595 0.156146613787591 NA NA NA 0.435125627697685 95.9503733227613 a1884 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 8 34 -1.38629436111989 0.693147180559945 0.464338556178076 -0.482608809987532 0.946947366165608 0.96316540699102 1.78161358844229 0.567837474983561 0.983161728289143 0.531511082037461 0.156231991029559 NA NA NA 0.0516042295857786 95.9503733227613 a1885 loss_cnaBRCA23 1175 AG-014699 PARP1, PARP2 3 40 1.6094379124341 NA 4.67372432484336 3.8006591228312 0.873065202012158 0.417294547975247 1.03106542278172 0.864576976355272 2.0922037113793 0.846760237247317 0.15625120142623 NA NA NA 0.0374205483964261 95.9503733227613 a1886 gain_cnaBRCA9_(KRAS) 211 TL-2-105 CRAF 4 45 2.32630161961136 1.63315443905142 3.16684544449073 3.97339447358892 -0.806549029098192 1.31776613770971 1.05419352817441 0.751709172708981 0.61205778932822 0.765086302981701 0.156285002233982 NA NA NA 0.311241889704656 95.9503733227613 a1887 gain_cnaBRCA31 345 KIN001-270 CDK9 16 33 2.99573227355399 NA 5.30851790949564 5.01016593541594 0.298351974079699 0.826631929467704 0.600032958985144 0.438367096642584 0.360924812415385 0.497225976693533 0.1567810225684 NA NA NA 0.210425931625836 96.0954678439081 a1888 BRCA2_mut 308 XL-880 MET 6 43 1.63315443905142 NA 0.977368469976427 1.96917488851692 -0.991806418540496 0.520641104194314 1.6636269171013 0.627015164103062 1.90497141034476 0.596171177771407 0.15684364283728 NA NA NA 0.0063135623314924 96.0954678439081 a1889 gain_cnaBRCA16 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 10 16 2.30258509299405 NA 3.12566714830448 2.42021476471635 0.705452383588134 1.41777861791354 1.04324526220179 0.589103208194004 0.497575837775226 0.676209525360566 0.156880157030311 NA NA NA 0.19378344054801 96.0954678439081 a1890 gain_cnaBRCA27_(CLTC,PPM1D) 282 EKB-569 EGFR 8 39 0.916290731874155 2.99573227355399 0.611895746846119 1.77625651979705 -1.16436077295093 2.4265151836625 2.01558333675874 0.558491235304532 0.479848954084633 0.577679300932969 0.157085363019041 NA NA NA 0.235534810904331 96.0954678439081 a1891 gain_cnaBRCA31 136 Mitomycin C DNA crosslinker 16 32 2.77258872223978 NA 0.293584499254373 -0.34825017820246 0.641834677456833 1.63508455333368 1.36315611106993 0.44039283458779 0.392539135757983 0.47084458797097 0.157113369234758 NA NA NA 0.187944334173647 96.0954678439081 a1892 loss_cnaBRCA38 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 4 43 2.32630161961136 NA 0.377726139141364 1.5136069864902 -1.13588084734884 0.665446768247058 1.55308807491471 0.752123798968827 1.70694471977227 0.731369241510154 0.157122830269122 NA NA NA 0.028543389848189 96.0954678439081 a1893 gain_cnaBRCA63 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 6 42 2.07944154167984 NA 3.84265536961793 3.12453889098746 0.718116478630469 1.42873233922186 1.10478642201576 0.627478267152021 0.502624920649296 0.65000480121779 0.157278162552731 NA NA NA 0.282847486050216 96.0954678439081 a1894 loss_cnaBRCA18 1019 Bosutinib SRC, ABL, TEC 14 31 0.693147180559945 NA 2.95625869507874 2.52997782089828 0.426280874180462 0.754061195901233 0.982952630334187 0.463459678387678 0.565313367797666 0.433673873008035 0.157306631157849 NA NA NA 0.12132161805796 96.0954678439081 a1895 gain_cnaBRCA31 1091 BMS-536924 IGF1R 15 32 1.38629436111989 NA 3.35372329302534 2.86841734083626 0.485305952189077 1.18586251930486 1.0262729082477 0.450000409966188 0.409243014505222 0.472881967641246 0.15732845098699 NA NA NA 0.185240241344874 96.0954678439081 a1896 loss_cnaBRCA23 206 Ruxolitinib JAK1, JAK2, TYK2 3 46 1.65632149833295 0.0237165266173161 3.85239181034296 4.40403449419969 -0.551642683856726 1.83712388849267 0.532481420007576 0.856223575461982 0.300275167783779 1.03598484966645 0.157368417445634 NA NA NA 0.65517591854518 96.0954678439081 a1897 loss_cnaBRCA34 1028 VX-702 p38 5 40 0.693147180559945 NA 3.0183538529793 3.47789112915804 -0.459537276178738 0.586555763105308 0.681584639787994 0.682503974215654 0.78345027887184 0.67421894413829 0.157434236548833 NA NA NA 0.161248974052202 96.0954678439081 a1898 gain_cnaBRCA14_(RAD21) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 21 27 0.246860077931526 2.32630161961136 -0.648099975451552 0.0330522095940926 -0.681152185045644 1.65236314202998 1.61216830340731 0.41794474169622 0.41222910855348 0.42250687078144 0.157641677567165 NA NA NA 0.159456679095616 96.1713901238253 a1899 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 40 1.38629436111989 NA 3.65664374877079 2.73890406824875 0.917739680522043 0.938813096163234 1.51305720934158 0.62892153258355 0.977553129875036 0.606546583206462 0.15791636955491 NA NA NA 0.071228362683429 96.2671190098101 a1900 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1527 GDC0941 (rescreen) PI3K 6 39 1.38629436111989 NA 1.60232934735969 0.885013763518064 0.717315583841627 1.74958710235919 1.03148065086748 0.63005532170249 0.409991353316666 0.695423208606347 0.158026457569494 NA NA NA 0.368575226663145 96.2671190098101 a1901 gain_cnaBRCA19 257 NPK76-II-72-1 PLK3 4 45 2.32630161961136 NA 2.40488161835564 3.57443395739849 -1.16955233904285 1.15092261301133 1.58683752878414 0.748441354409933 1.01618677556676 0.737033450386682 0.158054632167462 NA NA NA 0.131719789418199 96.2671190098101 a1902 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 9 39 2.77258872223978 NA 0.161740292965057 -0.574588931039257 0.736329224004314 1.27529466504251 1.41038392712052 0.53055961891018 0.577379678742537 0.522077152075622 0.158131151530062 NA NA NA 0.150178263427944 96.2671190098101 a1903 gain_cnaBRCA27_(CLTC,PPM1D) 256 JW-7-24-1 LCK 9 39 2.32630161961136 NA 2.3318165140571 1.72351203969719 0.608304474359912 1.79377997570617 0.957074179811743 0.530208942187759 0.339118778556125 0.635587593094995 0.158400326406117 NA NA NA 0.349916174692377 96.332959574687 a1904 gain_cnaBRCA12_(TERT) 288 KIN001-055 JAK3, MNK1 9 40 2.32630161961136 NA 3.97496792759526 4.42091577858196 -0.445947850986705 0.919110898228329 0.826970475740199 0.528771962675147 0.485194824526953 0.539254863467222 0.158405695682014 NA NA NA 0.207413290023702 96.332959574687 a1905 gain_cnaBRCA62 303 PIK-93 PI4K, PI3K 10 39 2.99573227355399 NA 2.22479362298033 2.93684350138227 -0.712049878401943 1.39777521319041 1.40324532589414 0.507809247990158 0.509416586932241 0.507430785809479 0.158580948819142 NA NA NA 0.17291686746039 96.3396331471653 a1906 loss_cnaBRCA7_(FAS,PTEN) 1003 Camptothecin TOP1 4 41 -2.30258509299405 NA -3.60040273122521 -2.4247818062542 -1.17562092497102 0.706145322857058 1.61038500107599 0.751506506984417 1.66484275533323 0.730024760653832 0.158618033249369 NA NA NA 0.03146524139373 96.3396331471653 a1907 PIK3CA_mut 177 GSK-650394 SGK3 17 30 2.77258872223978 NA 3.55039705542745 4.27739580619035 -0.726998750762907 2.19548317818958 1.29435533660005 0.434969747883843 0.331133828755818 0.561668600735678 0.15881692878139 NA NA NA 0.224922229175637 96.3396331471653 a1908 gain_cnaBRCA9_(KRAS) 167 OSU-03012 PDPK1 (PDK1) 4 44 2.77258872223978 NA 1.44761622716256 2.3207392821681 -0.87312305500554 0.913832277267995 1.18295808157867 0.747985598389078 0.955452194811766 0.738084526072425 0.158823499600062 NA NA NA 0.150074175257513 96.3396331471653 a1909 gain_cnaBRCA30_(CRNKL1,FOXA2) 258 STF-62247 stimulates autophagy 5 44 2.32630161961136 NA 5.20595314998946 4.56548946849492 0.640463681494548 1.0502186617295 0.937939289300983 0.675585454462339 0.609838412545284 0.682841297726067 0.158901395621985 NA NA NA 0.251243888372971 96.3396331471653 a1910 gain_cnaBRCA63 1017 Olaparib PARP1, PARP2 6 39 1.6094379124341 NA 4.55132304574755 4.00067887505937 0.550644170688184 1.24510124876562 0.81503984350909 0.628615568551568 0.442248508893622 0.675603990496254 0.158956933611733 NA NA NA 0.336658018215853 96.3396331471653 a1911 gain_cnaBRCA47_(EGFR) 140 Vinorelbine Microtubules 7 40 -2.74887219562247 NA -4.41004543792666 -3.45802715934418 -0.952018278582473 1.38087615398289 1.65650365794968 0.586774219905034 0.689430602329216 0.574715470149232 0.158999083637821 NA NA NA 0.136346100263405 96.3396331471653 a1912 gain_cnaBRCA30_(CRNKL1,FOXA2) 255 CP724714 ERBB2 5 43 2.32630161961136 NA 2.80643730295814 3.91891921804069 -1.11248191508255 1.84432936580157 1.62475272704352 0.676276580649818 0.603190479808389 0.684708446131907 0.159110840735944 NA NA NA 0.255710415553946 96.3466522308044 a1913 gain_cnaBRCA31 155 AP-24534 ABL 16 31 -0.669430653942629 NA 1.77042074363103 1.27758635047938 0.492834393151655 0.99139707889124 1.17671473305344 0.440676217129031 0.497110999865798 0.418822318874863 0.159177084132938 NA NA NA 0.139148148304327 96.3466522308044 a1914 TP53_mut 1203 QL-XII-61 BTK 20 3 2.30258509299405 NA 4.05291180498519 5.37387259196639 -1.32096078698121 1.51655841495136 0.784713227804223 0.90308476980493 0.871025325472591 1.68336755412867 0.159467192702324 NA NA NA 0.0700141425601771 96.4229862027575 a1915 loss_cnaBRCA18 59 WZ-1-84 BMX 5 7 2.32630161961136 NA 4.14555630209148 3.14499755124049 1.00055875085099 0.650830529055397 1.35139200655809 0.889539013313969 1.53735681745474 0.740391201069293 0.159682044714261 NA NA NA 0.1226315558341 96.4229862027575 a1916 gain_cnaBRCA30_(CRNKL1,FOXA2) 226 GSK1070916 AURKB 5 44 0.940007258491471 2.32630161961136 3.56662832464878 2.27182491200021 1.29480341264857 1.18874519172179 1.97544639800277 0.673998835829327 1.0892186329462 0.655448517336459 0.159861719728776 NA NA NA 0.0721142069500766 96.4229862027575 a1917 loss_cnaBRCA22_(SYNCRIP,ZNF292) 197 Bryostatin 1 PRKC 18 30 -4.8283137373023 NA -2.55317468995227 -2.95898146297354 0.405806773021266 0.883020696605475 0.991495426964205 0.425888876489303 0.45956654762598 0.409287589216401 0.159910474601316 NA NA NA 0.149211499903245 96.4229862027575 a1918 loss_cnaBRCA42 330 XMD13-2 RIPK 3 45 2.32630161961136 NA 2.76325738970915 3.78487216796708 -1.02161477825793 0.283509353089028 1.22494275682755 0.85171807094169 3.60346058120037 0.834010220121457 0.159939117968971 NA NA NA 0.00220031338328234 96.4229862027575 a1919 gain_cnaBRCA47_(EGFR) 1129 PF-4708671 RPS6KB1 (p70S6KA) 7 36 2.30258509299405 NA 4.36649623452572 3.70055844617272 0.665937788352994 0.888583013996413 1.16282886833262 0.590961328868636 0.749437900413976 0.572687698498472 0.160116181303143 NA NA NA 0.115315014971845 96.4229862027575 a1920 loss_cnaBRCA20 221 TAK-715 p38a 3 46 2.99573227355399 2.32630161961136 3.68952137366191 4.53384606217173 -0.844324688509814 0.729753481204363 1.00291835696461 0.850425157866759 1.15699987770715 0.841867817700749 0.160139422644759 NA NA NA 0.172223688320738 96.4229862027575 a1921 gain_cnaBRCA16 6 PHA-665752 MET 3 11 0.693147180559945 NA 3.4147539231991 2.71429443843867 0.700459484760431 0.638002505816066 0.733956940492599 0.974410593420477 1.09789456683164 0.954360461923439 0.160480260296716 NA NA NA 0.186041911364142 96.4229862027575 a1922 MLL3_mut 1026 17-AAG HSP90 3 40 0 NA 0.502292132141056 -1.00109405890337 1.50338619104442 0.562646212256277 1.79842073866796 0.854971528883844 2.67199202322125 0.835947984095167 0.160790199127433 NA NA NA 0.0129070205788229 96.4229862027575 a1923 loss_cnaBRCA24 1248 FK866 NAMPT 3 41 0 NA 1.47535722360028 -0.806271462607553 2.28162868620783 1.1545764783716 2.72619322247123 0.853776622003181 1.97616072122464 0.836928456648275 0.160834475995176 NA NA NA 0.04573391130692 96.4229862027575 a1924 MACF1_mut 1527 GDC0941 (rescreen) PI3K 3 42 1.38629436111989 NA 0.0742961023217751 1.04539582272375 -0.971099720401971 0.717559313707391 1.15548322233112 0.852698430274976 1.35333721108659 0.840427365481632 0.16084806578512 NA NA NA 0.126603154954153 96.4229862027575 a1925 gain_cnaBRCA47_(EGFR) 275 I-BET BRD2, BRD3, BRD4 7 42 2.99573227355399 NA 4.70734130230263 3.92754101883664 0.77980028346599 1.46643513750279 1.32133081510167 0.5816238747435 0.531765956449952 0.590162792355666 0.160855867684107 NA NA NA 0.2245295483201 96.4229862027575 a1926 loss_cnaBRCA17 204 Tipifarnib Farnesyl-transferase (FNTA) 11 37 2.77258872223978 NA 1.05697502502707 1.78735535256124 -0.730380327534166 1.16982470641129 1.57097616323887 0.489214082381565 0.624350232587219 0.46492133020551 0.161038681365633 NA NA NA 0.10903608549796 96.4229862027575 a1927 gain_cnaBRCA14_(RAD21) 1377 Afatinib (rescreen) ERBB2, EGFR 21 26 2.30258509299405 NA 2.3815333986799 3.20061095145573 -0.819077552775834 2.34203041180843 1.58919927726646 0.417934200005865 0.349729682691599 0.515402671328109 0.161206965103439 NA NA NA 0.180220660604702 96.4229862027575 a1928 gain_cnaBRCA62 1009 ATRA Retinoic acid and retinoid X receptor agonist 8 37 2.30258509299405 NA 4.62693236906925 3.99333054780561 0.633601821263636 0.726161736852164 1.20421657857111 0.555724802663312 0.872535399634569 0.526152714169948 0.161295824670915 NA NA NA 0.0676622731911851 96.4229862027575 a1929 gain_cnaBRCA47_(EGFR) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 7 40 0.940007258491471 NA 1.2752754737901 1.99600076667855 -0.720725292888449 1.13227226112362 1.25065050969817 0.583336560571781 0.636530026950612 0.576280333554086 0.161401437286437 NA NA NA 0.161531155079405 96.4229862027575 a1930 PIK3CA_mut 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 15 28 1.6094379124341 NA 3.03627613576347 2.31612635942731 0.720149776336162 1.12448041803657 1.76843468449052 0.456262113213901 0.640428917022492 0.407224413008862 0.161452284584595 NA NA NA 0.111730229017597 96.4229862027575 a1931 MLL3_mut 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 40 1.6094379124341 NA 3.82061402077866 2.47334595095202 1.34726806982664 1.12967989266408 1.59798633754907 0.853582404367752 1.19261047184741 0.843103622458396 0.161455088525827 NA NA NA 0.162045704249817 96.4229862027575 a1932 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 71 Pyrimethamine Dihydrofolate reductase (DHFR) 3 11 2.99573227355399 NA 5.29463870082414 4.37180669942239 0.922832001401746 0.29420999705744 1.0318056412815 0.971880183936303 3.13664392995313 0.894385497113188 0.16148184613381 NA NA NA 0.0235318925222037 96.4229862027575 a1933 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 197 Bryostatin 1 PRKC 6 42 -4.8283137373023 NA -3.32462593032418 -2.73282935062862 -0.591796579695558 0.757501861107162 0.974167434610247 0.620978896617662 0.78124769070612 0.607489594365602 0.161528840538531 NA NA NA 0.125571928949624 96.4229862027575 a1934 gain_cnaBRCA58_(CCND1) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 10 39 3.68887945411394 NA 3.93222995354578 3.33823519717404 0.593994756371742 1.16948052259935 1.18124603660904 0.503811425623454 0.50791333835257 0.502854391009768 0.161815485878755 NA NA NA 0.174513067136185 96.4229862027575 a1935 gain_cnaBRCA27_(CLTC,PPM1D) 177 GSK-650394 SGK3 9 38 2.77258872223978 NA 3.30169566006269 4.18324639966877 -0.881550739606079 2.6610867171422 1.36695367923003 0.527271374010971 0.331274713419635 0.644901691257477 0.161827440868244 NA NA NA 0.36009487489991 96.4229862027575 a1936 gain_cnaBRCA31 326 GSK690693 AKT 16 32 2.32630161961136 NA 3.4917819050114 2.66347642325836 0.828305481753043 1.78165202566251 1.95909574928287 0.435250995935775 0.464908674546051 0.422799897379311 0.161909203676781 NA NA NA 0.151602590121844 96.4229862027575 a1937 BRCA2_mut 165 DMOG Prolyl-4-Hydroxylase 6 40 8.29404964010203 NA 6.75082120445295 7.69285448389483 -0.942033279441887 2.07432104383357 1.42496757889138 0.622683668931087 0.454140540222697 0.661091026488328 0.16198720384959 NA NA NA 0.325542185703606 96.4229862027575 a1938 loss_cnaBRCA33 304 SB52334 ALK5 6 43 2.99573227355399 NA 3.61945712344028 4.39711518378077 -0.777658060340487 1.36610296639258 1.24240816198754 0.619082401524874 0.569252889036632 0.625928003480298 0.162044480913235 NA NA NA 0.233313033959235 96.4229862027575 a1939 MLL3_mut 173 FH535 unknown 3 45 3.46573590279973 NA 0.570346576985517 1.63984150307805 -1.06949492609253 0.857801822578843 1.27781155035917 0.847152053646392 1.24678556041915 0.836973907296358 0.162142400989618 NA NA NA 0.149880244926104 96.4229862027575 a1940 ASH1L_mut 277 ABT-869 VEGFR and PDGFR family 3 45 0.0237165266173161 NA 2.3187661724613 2.7158990529556 -0.397132880494302 0.149091594559684 0.47835358731116 0.846998561413403 2.66368390295351 0.830207802405323 0.162216876049821 NA NA NA 0.0136363546150083 96.4229862027575 a1941 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1262 UNC1215 LMBL3 6 40 0 NA 3.07423653421577 2.71001287619022 0.364223658025543 0.80176551851538 0.551581044884285 0.622157150652246 0.454277029398784 0.660326639944548 0.162334526291315 NA NA NA 0.325436201707221 96.4229862027575 a1942 gain_cnaBRCA31 341 EX-527 SIRT1 16 33 2.99573227355399 NA 5.82980234837858 5.55057791293213 0.279224435446453 0.613697765988743 0.660199855139206 0.432421582314443 0.454986885925172 0.422939255852423 0.162360720241075 NA NA NA 0.155012246237809 96.4229862027575 a1943 gain_cnaBRCA27_(CLTC,PPM1D) 6 PHA-665752 MET 3 11 0.693147180559945 NA 3.41244696220143 2.71492360961985 0.697523352581576 0.637526127811373 0.734698472040529 0.969570032844372 1.09410943670054 0.949400848274933 0.162400894040584 NA NA NA 0.187248850344903 96.4229862027575 a1944 NF1_mut 136 Mitomycin C DNA crosslinker 5 43 2.77258872223978 NA 0.742050622571735 -0.236207135517847 0.978257758089581 0.650679659140671 1.51280770702215 0.670859030492685 1.50343989449667 0.646650432535944 0.162405316642771 NA NA NA 0.0245505829347302 96.4229862027575 a1945 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 326 GSK690693 AKT 6 42 2.32630161961136 NA 3.97123810131954 2.79219827182221 1.17903982949733 1.21636035620322 1.97061598655802 0.619514586779775 0.96931786989311 0.598310293603526 0.162498777559183 NA NA NA 0.0725510295476496 96.4229862027575 a1946 MLL3_mut 1004 Vinblastine Microtubules 3 42 -2.30258509299405 NA -2.45336643093503 -3.52714563598708 1.07377920505205 1.62730278856213 1.24395886422051 0.849261168300457 0.659852126229583 0.863195107118681 0.162503705803802 NA NA NA 0.371366753901387 96.4229862027575 a1947 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 201 Epothilone B Microtubules 6 42 -3.44201937618241 NA -5.20018686892986 -4.0979823613221 -1.10220450760776 1.57849869077452 1.8026967546228 0.619321769197765 0.698261274494275 0.611419810226701 0.162626834506204 NA NA NA 0.160285664469132 96.4229862027575 a1948 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1013 Nilotinib ABL 17 23 0.693147180559945 NA 3.44940054386499 3.02071678480512 0.428683759059871 0.905116706629164 0.967433566619251 0.455224412483227 0.473622634429515 0.443114415140597 0.162820001213566 NA NA NA 0.159137336092388 96.4229862027575 a1949 BRCA1_mut 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 4 41 2.30258509299405 NA 2.10134632117083 1.29351696110251 0.807829360068323 0.823429157949768 1.10324041586364 0.743816134022836 0.98105508199359 0.732233290634058 0.162824434181851 NA NA NA 0.142231615903764 96.4229862027575 a1950 loss_cnaBRCA57 206 Ruxolitinib JAK1, JAK2, TYK2 5 44 1.65632149833295 0.0237165266173161 4.7575651511701 4.32624855473554 0.431316596434559 0.242170940392381 0.669890354538829 0.669087927960153 1.78104191913246 0.643861481975643 0.162862839060781 NA NA NA 0.0120586958051733 96.4229862027575 a1951 loss_cnaBRCA29_(MAP2K4) 1036 PLX4720 BRAF 5 38 2.30258509299405 NA 3.88949716070052 4.68965758959204 -0.800160428891525 2.66011654036143 0.887524153278653 0.67596613039996 0.300799012656343 0.901564679604051 0.16290334232139 NA NA NA 0.539866805743256 96.4229862027575 a1952 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1009 ATRA Retinoic acid and retinoid X receptor agonist 17 28 2.30258509299405 NA 4.41565961457128 3.91794556334464 0.497714051226644 0.979621367105299 1.22568103411966 0.436459821350352 0.508067777959303 0.406071430797758 0.162956734778966 NA NA NA 0.141547896877381 96.4229862027575 a1953 loss_cnaBRCA36_(FAT1,IRF2) 184 BMS-754807 IGF1R 9 39 0.940007258491471 NA 0.921844281142194 1.7895669562655 -0.867722675123301 1.82173310089373 1.61841477523061 0.524123505536942 0.476317126091414 0.536155927642008 0.163128690986624 NA NA NA 0.215261585244763 96.4229862027575 a1954 loss_cnaBRCA17 1025 SB 216763 GSK3A, GSK3B 8 31 2.30258509299405 NA 5.23597070564278 4.79966214036739 0.436308565275392 0.511551810202529 0.822437169539889 0.564240060319986 0.852911780534317 0.530506865976746 0.163158410307459 NA NA NA 0.0784194244554789 96.4229862027575 a1955 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 208 SB-715992 KIF11 6 43 -2.05572501506252 NA -2.15284939926439 -1.1125108953302 -1.04033850393419 1.417009367124 1.7142591480654 0.617363581094194 0.734178988559332 0.606873531990921 0.163188882552593 NA NA NA 0.14398742248639 96.4229862027575 a1956 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1023 GW 441756 NTRK1 6 39 0.693147180559945 NA 3.050288748724 2.25297879738252 0.797309951341483 1.09635669459414 1.30513962591406 0.621630911879013 0.727235903490917 0.610900117895877 0.163531973333861 NA NA NA 0.148384163886419 96.4229862027575 a1957 loss_cnaBRCA29_(MAP2K4) 206 Ruxolitinib JAK1, JAK2, TYK2 7 42 1.65632149833295 0.0237165266173161 4.05112250203949 4.42345011071281 -0.372327608673324 1.13392741652057 0.536922329866695 0.577528596516446 0.32835224128878 0.69344780047752 0.163762214604391 NA NA NA 0.424200315071139 96.4229862027575 a1958 gain_cnaBRCA62 265 Tubastatin A HDAC6 10 39 2.99573227355399 NA 4.28433318811979 4.79622777670068 -0.511894588580895 1.4903710557336 0.873974517009937 0.501254803876725 0.34346788111027 0.58570882630789 0.163910783831738 NA NA NA 0.320866222264087 96.4229862027575 a1959 loss_cnaBRCA18 194 AUY922 HSP90 15 32 -1.36257783450257 NA -2.90725193011304 -2.15304167389096 -0.754210256222084 0.919513634871341 1.95717164978052 0.442746362388154 0.820227376321193 0.385357235430352 0.163979889393708 NA NA NA 0.0789843183090178 96.4229862027575 a1960 loss_cnaBRCA18 158 PF-562271 FAK 14 31 0.940007258491471 NA 1.93433187387754 2.51340687147201 -0.579074997594467 0.947476918941846 1.38675971604106 0.455936173058547 0.611175835545614 0.417574141284994 0.163998269399696 NA NA NA 0.111798148862395 96.4229862027575 a1961 gain_cnaBRCA27_(CLTC,PPM1D) 276 CAY10603 HDAC6 9 40 2.99573227355399 NA 0.758937741438468 1.26927519628264 -0.510337454844174 1.07393453178111 0.957834016358646 0.521513995099774 0.475203506118555 0.532803644606714 0.164075881713742 NA NA NA 0.215819320440985 96.4229862027575 a1962 ASH1L_mut 286 KIN001-236 TIE2 3 46 2.32630161961136 NA 3.94169188488353 4.57913086743243 -0.637438982548899 0.511214703561042 0.765893820572431 0.842277132593477 1.24691050180795 0.832281140579611 0.16409743686239 NA NA NA 0.149944103107403 96.4229862027575 a1963 loss_cnaBRCA28_(GPS2) 238 CAL-101 PI3Kdelta 4 45 2.99573227355399 2.32630161961136 5.35057551290002 4.66282099334598 0.68775451955404 0.855673725317142 0.937911251069977 0.737238976671312 0.803757903515308 0.733283153144227 0.164240133432845 NA NA NA 0.207435525757714 96.4229862027575 a1964 gain_cnaBRCA8_(CHD4,WNK1) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 3 40 0.693147180559945 NA 2.16630984509892 2.96407685714732 -0.797767012048396 0.441538249078074 0.959825963397999 0.847616454765755 1.80679026950467 0.831157983291181 0.164335126632761 NA NA NA 0.060399244330306 96.4229862027575 a1965 loss_cnaBRCA22_(SYNCRIP,ZNF292) 274 PXD101, Belinostat HDAC 18 30 2.99573227355399 NA 1.05997638325541 0.438419523592145 0.621556859663261 1.83897947438383 1.21258942004053 0.421282010652757 0.337990101750059 0.512586411682932 0.164380064723 NA NA NA 0.212879455296561 96.4229862027575 a1966 gain_cnaBRCA10_(MDM2,NUP107) 286 KIN001-236 TIE2 5 44 2.32630161961136 NA 4.99310716031471 4.48862635806747 0.504480802247243 0.45828102197719 0.778803376446194 0.666572433941055 1.1008110265416 0.647764015288776 0.164416984796436 NA NA NA 0.0701398355457895 96.4229862027575 a1967 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 29 AZ628 BRAF 4 10 1.38629436111989 NA 3.70300988699417 1.99931864465378 1.70369124234039 1.04084603931685 2.16374866008435 0.876029754373253 1.63683309345019 0.787379455742318 0.164442782279402 NA NA NA 0.0726009079252972 96.4229862027575 a1968 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 5 40 0.693147180559945 NA 1.46889685420024 0.520152930875138 0.948743923325105 1.28584201137648 1.42744041659862 0.670553715636868 0.737838641863542 0.664646952890561 0.164663416611639 NA NA NA 0.181764578251465 96.4229862027575 a1969 NF1_mut 346 THZ-2-102-1 CDK7 5 43 0.916290731874155 2.99573227355399 0.164921297494054 -1.50958542195471 1.67450671944876 2.41752498234253 2.51870448255423 0.667116031014602 0.692653325892916 0.664828577964271 0.164712361286932 NA NA NA 0.203523067567531 96.4229862027575 a1970 loss_cnaBRCA29_(MAP2K4) 229 LY317615 PRKCB (PKCbeta) 7 42 2.99573227355399 2.32630161961136 2.57215723923052 3.48965404413483 -0.917496804904305 1.73506460797273 1.57052688406314 0.576143889967213 0.528796910897928 0.584196815867699 0.164754104899367 NA NA NA 0.227036398729651 96.4229862027575 a1971 MLL3_mut 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 46 3.68887945411394 NA 2.52842162855898 3.5201784204254 -0.991756791866423 0.744348289997942 1.19501006246816 0.840937695123988 1.33238271007402 0.829915013282868 0.164755307281787 NA NA NA 0.131450956312083 96.4229862027575 a1972 gain_cnaBRCA48 328 SNX-2112 HSP90 5 43 0.940007258491471 NA 1.61901158291593 0.277499069997005 1.34151251291893 1.47882066859133 2.05586434787757 0.666667472372009 0.907150232216327 0.65252968383049 0.164990538004722 NA NA NA 0.116752802844647 96.4229862027575 a1973 gain_cnaBRCA30_(CRNKL1,FOXA2) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 5 44 3.68887945411394 NA 4.16434508567532 3.37935788174701 0.784987203928306 1.3395575810339 1.16335631530592 0.665594532947933 0.586004823564535 0.674760770711839 0.165024263752655 NA NA NA 0.267274653787884 96.4229862027575 a1974 loss_cnaBRCA17 300 CX-5461 RNA Pol I 11 38 2.32630161961136 NA 3.28132069412058 4.09503609822726 -0.813715404106683 2.18667189992073 1.52183776755606 0.48280247224816 0.372125056409323 0.53469260748696 0.165084752293492 NA NA NA 0.268659995495402 96.4229862027575 a1975 gain_cnaBRCA63 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 6 41 2.99573227355399 NA 3.09018560535373 3.95851261661364 -0.868327011259912 0.821679277611489 1.46471966109056 0.616775030061732 1.05677121830798 0.592828125631492 0.165103488344302 NA NA NA 0.0570187606456818 96.4229862027575 a1976 BRCA2_mut 172 Embelin XIAP 6 42 3.46573590279973 NA 2.47899725897887 3.06650002562771 -0.587502766648834 0.603261924119795 0.989087469457908 0.615358295722796 0.973876757605819 0.593984642198357 0.165276570088924 NA NA NA 0.0718429013389362 96.4229862027575 a1977 loss_cnaBRCA38 330 XMD13-2 RIPK 4 44 2.32630161961136 NA 2.91097448844766 3.79466185849671 -0.883687370049049 0.499759641522416 1.2342485720157 0.736327393061766 1.76822475571872 0.715971960660942 0.165277560216555 NA NA NA 0.0248110874064415 96.4229862027575 a1978 NF1_mut 303 PIK-93 PI4K, PI3K 5 44 2.99573227355399 NA 3.62955514003209 2.69629675189889 0.933258388133198 1.79532890884515 1.36093164030172 0.665117990608666 0.519825856719212 0.685749644211587 0.165320828618329 NA NA NA 0.31609949201161 96.4229862027575 a1979 CDH1_mut 328 SNX-2112 HSP90 4 44 0.940007258491471 NA -0.94074902164634 0.540693500250823 -1.48144252189716 1.70313778084253 2.0321584377312 0.736178659636876 0.869831283505613 0.728999518143437 0.165361198356246 NA NA NA 0.18027799826263 96.4229862027575 a1980 gain_cnaBRCA30_(CRNKL1,FOXA2) 277 ABT-869 VEGFR and PDGFR family 5 43 0.0237165266173161 NA 2.97091949608403 2.65853856790618 0.312380928177854 0.681488130763831 0.443509109587641 0.666027395475412 0.458380585187491 0.704339373025043 0.165388118435722 NA NA NA 0.368783134620062 96.4229862027575 a1981 gain_cnaBRCA58_(CCND1) 1192 GSK269962A ROCK1, ROCK2 9 37 1.6094379124341 NA 3.27630870825679 2.51996294537344 0.756345762883357 1.32115120641684 1.46872377586061 0.524142556681773 0.572489930910088 0.514968011898745 0.165499695685395 NA NA NA 0.155511861417547 96.4229862027575 a1982 loss_cnaBRCA18 308 XL-880 MET 16 33 1.63315443905142 NA 1.39036687850997 2.06948063545232 -0.679113756942351 1.281745026532 1.70627088200941 0.428950001506065 0.52983529710259 0.398010517616396 0.165689513886919 NA NA NA 0.128289875471511 96.4229862027575 a1983 gain_cnaBRCA19 172 Embelin XIAP 4 44 3.46573590279973 NA 2.34933812786507 3.05158254815402 -0.702244420288949 0.756954375509023 0.967069665873288 0.735506208913992 0.927723576228378 0.726157013367599 0.165739752180481 NA NA NA 0.159317980428715 96.4229862027575 a1984 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1149 TW 37 BCL2, BCL2L1 13 30 1.6094379124341 NA 0.259082664106638 -0.31635323508756 0.575435899194198 1.5110859739686 1.08984017106333 0.468527727943059 0.380809503302395 0.528000265059745 0.165781846963755 NA NA NA 0.231088988213873 96.4229862027575 a1985 gain_cnaBRCA16 1378 Bleomycin (50 uM) DNA damage 17 31 3.91202300542815 NA 4.32324433097921 3.53275134856595 0.790492982413261 1.93472322257231 1.8199248906452 0.424845872763342 0.408581947635001 0.43435472885533 0.165936335882521 NA NA NA 0.176644122650348 96.4229862027575 a1986 loss_cnaBRCA38 140 Vinorelbine Microtubules 4 43 -2.74887219562247 NA -4.69317506499321 -3.49810939951817 -1.19506566547504 0.612568446142233 1.67263899573593 0.736038854075674 1.9509096052877 0.714479136574976 0.165989520226151 NA NA NA 0.0163751734439533 96.4229862027575 a1987 gain_cnaBRCA16 206 Ruxolitinib JAK1, JAK2, TYK2 16 33 1.65632149833295 0.0237165266173161 4.55634650517175 4.28003691155959 0.276309593612161 0.62847461174182 0.652371675004343 0.428492477718815 0.439651162433384 0.423546276147445 0.166132144695451 NA NA NA 0.164124144726697 96.4229862027575 a1988 gain_cnaBRCA58_(CCND1) 306 TG101348 JAK2 10 38 2.32630161961136 NA 3.72598038918935 3.09302275862232 0.63295763056703 1.0898416221764 1.30517868903519 0.499992985443117 0.580779461609312 0.484958600599678 0.16620467843075 NA NA NA 0.136585237354656 96.4229862027575 a1989 gain_cnaBRCA58_(CCND1) 1378 Bleomycin (50 uM) DNA damage 9 39 3.91202300542815 NA 4.59900104432686 3.63126759059613 0.967733453730733 1.50069423666397 1.92797980735342 0.520082428839643 0.644857180155494 0.50194169567531 0.166328848934554 NA NA NA 0.120764718258165 96.4229862027575 a1990 loss_cnaBRCA42 274 PXD101, Belinostat HDAC 3 45 2.99573227355399 NA -0.488666149522507 0.748847978998426 -1.23751412852093 0.609694525847819 1.50323745911019 0.83860512493886 2.02972812786877 0.823232631026541 0.166330132241029 NA NA NA 0.0423779251764363 96.4229862027575 a1991 loss_cnaBRCA34 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 37 -1.38629436111989 0.693147180559945 0.68570298839753 -0.435743406274031 1.12144639467156 1.1582488968715 1.71708852543135 0.671668370580439 0.968225739476774 0.653109247462848 0.166366573114067 NA NA NA 0.101166187423215 96.4229862027575 a1992 loss_cnaBRCA60 221 TAK-715 p38a 3 46 2.99573227355399 2.32630161961136 3.70097482235095 4.53309909812679 -0.832124275775836 0.74403471061961 1.00309015585915 0.837616018962663 1.11839442958631 0.829560803598074 0.166395606247141 NA NA NA 0.182473674658276 96.4229862027575 a1993 MLL3_mut 273 CUDC-101 HDAC, EGFR 3 46 1.63315443905142 NA -1.24392636988372 0.0527391751350117 -1.29666554501873 0.944943797498063 1.56952889300071 0.837589072744597 1.37221446233302 0.826149522191777 0.1664089643766 NA NA NA 0.123522663765828 96.4229862027575 a1994 loss_cnaBRCA17 235 QL-XII-47 BTK, BMX 11 38 2.32630161961136 NA 1.1541528632725 1.86842100395297 -0.714268140680473 1.37568579120664 1.51253371198949 0.481159066521574 0.519208779538223 0.4722328732369 0.166498591116961 NA NA NA 0.155953652066145 96.4229862027575 a1995 loss_cnaBRCA57 279 BIX02189 MAP2K5 (MEK5) 5 44 2.99573227355399 NA 5.55633191778231 4.96724514985921 0.589086767923102 0.921084253955251 0.885098110892417 0.663223536513295 0.639557961601764 0.665560982080443 0.166503892943234 NA NA NA 0.233154986807775 96.4229862027575 a1996 PTEN_mut 1175 AG-014699 PARP1, PARP2 7 36 1.6094379124341 NA 3.36918754772235 3.95731180704782 -0.588124259325473 1.15922114002284 0.983381340388852 0.581710282797761 0.507344318542952 0.598063269222614 0.166601783512615 NA NA NA 0.245141824876235 96.4229862027575 a1997 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 206 Ruxolitinib JAK1, JAK2, TYK2 9 40 1.65632149833295 0.0237165266173161 4.09752859059409 4.43162512122169 -0.334096530627598 0.935770466157524 0.567062260488682 0.518072116947265 0.357028291349556 0.589170808756839 0.166819398799874 NA NA NA 0.329147139760057 96.4229862027575 a1998 TP53_mut 262 VX-11e ERK 38 11 1.63315443905142 NA 3.91855264813775 3.2871622414849 0.631390406652853 1.05494384358255 1.99701184683177 0.480782539357978 0.598506176886793 0.31616758190721 0.166823840599477 NA NA NA 0.333610936075111 96.4229862027575 a1999 gain_cnaBRCA8_(CHD4,WNK1) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 44 2.99573227355399 NA 2.74269251686804 3.92300121278813 -1.18030869592009 0.353642238713116 1.43847152851098 0.838217616349619 3.3375783962209 0.820529758515189 0.166965170149198 NA NA NA 0.00364228181249158 96.4229862027575 a2000 gain_cnaBRCA27_(CLTC,PPM1D) 1009 ATRA Retinoic acid and retinoid X receptor agonist 10 35 2.30258509299405 NA 3.65872815827031 4.23375450396168 -0.575026345691369 1.46996572247935 1.03636567046263 0.504038406756405 0.391183506457203 0.554848893667693 0.166999195060432 NA NA NA 0.270175670201612 96.4229862027575 a2001 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 345 KIN001-270 CDK9 6 43 2.99573227355399 NA 5.47327221139268 5.05656114307674 0.416711068315941 0.682689988797533 0.681133552219178 0.611641709548388 0.610395750858924 0.611790546741191 0.16704389207791 NA NA NA 0.207299669776502 96.4229862027575 a2002 TP53_mut 1004 Vinblastine Microtubules 35 10 -2.30258509299405 NA -3.59721150526295 -2.95978133200593 -0.637430173257016 1.28248604441137 1.1966143479904 0.503899224665255 0.497026986012608 0.532694743571742 0.167113818691706 NA NA NA 0.163890871643816 96.4229862027575 a2003 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 9 MG-132 Proteasome 5 9 0 NA 1.1229574529954 -0.111881007434671 1.23483846043007 0.443173655306071 1.81756735440927 0.819982188397319 2.78635348840231 0.679390756790638 0.167261918583876 NA NA NA 0.0827249040999782 96.4229862027575 a2004 loss_cnaBRCA29_(MAP2K4) 1377 Afatinib (rescreen) ERBB2, EGFR 7 40 2.30258509299405 NA 3.79415037638325 2.6667258368861 1.12742453949715 1.92340840294648 1.96680973675312 0.574900292126438 0.586159724461033 0.57322501431091 0.167417030812355 NA NA NA 0.190189780070674 96.4229862027575 a2005 gain_cnaBRCA58_(CCND1) 1143 HG-5-88-01 EGFR, ADCK4 5 21 2.30258509299405 NA 3.98884719167051 4.66389367965271 -0.675046487982195 1.05103173740597 0.932369911712461 0.708209610974029 0.642270317781521 0.7240114459961 0.16754480552665 NA NA NA 0.238850376795823 96.4229862027575 a2006 loss_cnaBRCA20 164 JQ12 HDAC 3 44 1.63315443905142 NA 2.84634610177543 1.49139706241205 1.35494903936337 1.4636694610799 1.62603220064332 0.836821254347291 0.925720646220006 0.833285490181132 0.16765824310824 NA NA NA 0.245135412599093 96.4229862027575 a2007 POLR2B_mut 136 Mitomycin C DNA crosslinker 3 45 2.77258872223978 NA -1.27762627454237 -0.0580838864618137 -1.21954238808056 1.60473197724637 1.45201577670374 0.835882372116866 0.759966402721797 0.83989610006103 0.167681696654392 NA NA NA 0.317261878800718 96.4229862027575 a2008 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 268 YM155 BIRC5 (Survivin) 6 43 1.63315443905142 NA -4.44097415899586 -3.47761574750903 -0.963358411486822 1.12395706036456 1.62310393410876 0.610675847534156 0.857113181151558 0.59352848036549 0.167701537510585 NA NA NA 0.100696150653426 96.4229862027575 a2009 PIK3CA_mut 1199 Tamoxifen ER 16 31 1.6094379124341 NA 3.60166048600957 4.00723976360109 -0.405579277591512 1.24036453633445 0.746137159289108 0.431374120686877 0.32698393553728 0.543572012923111 0.16796942689122 NA NA NA 0.24341866287548 96.4229862027575 a2010 gain_cnaBRCA19 171 AKT inhibitor VIII AKT1, AKT2, AKT3 4 43 0.940007258491471 NA 1.06007380201642 1.96573636687458 -0.90566256485816 1.61216279103404 1.20503773690002 0.732524921934195 0.5617686811127 0.75156365408771 0.16797738028761 NA NA NA 0.346375628613685 96.4229862027575 a2011 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 257 NPK76-II-72-1 PLK3 6 43 2.32630161961136 NA 2.64140403666073 3.59582861247419 -0.954424575813453 1.50364866872258 1.57125880929204 0.610165855351329 0.634739082118352 0.607426714281073 0.168049594640667 NA NA NA 0.193160425855268 96.4229862027575 a2012 loss_cnaBRCA57 150 Bicalutamide ANDR (androgen receptor) 5 43 0.0237165266173161 NA 3.12726699026988 2.72018317986931 0.407083810400571 0.233986052665535 0.639773233145602 0.661703220236954 1.73977810114377 0.636293907450682 0.168093592261072 NA NA NA 0.0137445709185267 96.4229862027575 a2013 gain_cnaBRCA9_(KRAS) 272 AR-42 HDAC 4 45 1.63315443905142 NA -0.870981851650221 0.232008662260278 -1.1029905139105 1.39904485368772 1.51753184523165 0.730338015078097 0.788388242880949 0.726831873331876 0.168143258123495 NA NA NA 0.21439055429512 96.4229862027575 a2014 PTEN_mut 224 AS605240 PI3Kgamma 9 40 2.99573227355399 2.32630161961136 3.92789110437736 3.12228901943682 0.805602084940539 0.918596614957365 1.6615107158004 0.516331574790308 0.876992220331586 0.484861203288994 0.168220266261173 NA NA NA 0.0585447113005751 96.4229862027575 a2015 gain_cnaBRCA9_(KRAS) 256 JW-7-24-1 LCK 4 44 2.32630161961136 NA 2.60715219564957 1.76760703163878 0.839545164010791 1.78931230870695 1.08975559182092 0.73102946592313 0.469199904301497 0.770397665597624 0.168277104391769 NA NA NA 0.420110641975477 96.4229862027575 a2016 loss_cnaBRCA18 283 GSK2126458 PI3K, MTOR 15 33 -2.05572501506252 0.0237165266173161 -3.53853929018249 -2.83573000120008 -0.702809288982409 0.869755492322448 1.84570256217454 0.435859410419836 0.808053867076764 0.38078144517196 0.16831759495843 NA NA NA 0.0795850734685605 96.4229862027575 a2017 CDH1_mut 208 SB-715992 KIF11 4 45 -2.05572501506252 NA -2.37012380016014 -1.13943488209209 -1.23068891806805 0.533670245103776 1.73693012668075 0.729953748345846 2.30608494544928 0.708542559751599 0.168362691171488 NA NA NA 0.00723889913500406 96.4229862027575 a2018 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 152 CP466722 ATM 6 43 2.77258872223978 NA 2.16973293111488 2.8083383415464 -0.638605410431528 0.691975038895922 1.08221804062211 0.60956839012884 0.922873477416832 0.590089414943062 0.168458061732865 NA NA NA 0.0831781822006623 96.4229862027575 a2019 gain_cnaBRCA19 273 CUDC-101 HDAC, EGFR 4 45 1.63315443905142 NA -1.06439149989067 0.0655953099138235 -1.12998680980449 0.877488717903007 1.58382795780449 0.729777251010752 1.28775081291631 0.713453001152273 0.168463553164769 NA NA NA 0.0730425901856482 96.4229862027575 a2020 loss_cnaBRCA17 1054 PD-0332991 CDK4, CDK6 6 36 1.38629436111989 0.693147180559945 3.64793782806595 2.75539922335735 0.8925386047086 1.34753718862423 1.45643419341646 0.618413528205962 0.662348031834161 0.61282453319426 0.168500616272296 NA NA NA 0.18071239925457 96.4229862027575 a2021 loss_cnaBRCA38 200 LAQ824 HDAC 4 44 0.0237165266173161 NA -3.616824440975 -2.5997076797859 -1.01711676118911 0.33614090006688 1.43716733288475 0.730602186410769 3.02586433542225 0.707723267789217 0.168520846292727 NA NA NA 0.00162793168355546 96.4229862027575 a2022 MLL3_mut 276 CAY10603 HDAC6 3 46 2.99573227355399 NA 0.410063391407519 1.22546211630499 -0.815398724897467 0.917572850472965 0.981655748642331 0.832877261791527 0.888647396745847 0.830636122719391 0.168757584249432 NA NA NA 0.259707213075411 96.4229862027575 a2023 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1023 GW 441756 NTRK1 8 37 0.693147180559945 NA 2.93517128451532 2.23477122470648 0.700400059808844 1.33390097761726 1.27325704696562 0.545769987673522 0.525076502350245 0.550085359023152 0.168762930419167 NA NA NA 0.20461744456201 96.4229862027575 a2024 loss_cnaBRCA57 257 NPK76-II-72-1 PLK3 5 44 2.32630161961136 NA 4.40546890554661 3.37367522792321 1.0317936776234 0.798648977942533 1.61721689738058 0.659580850814054 1.29192386908388 0.638005748823555 0.168797155090356 NA NA NA 0.0426231151263032 96.4229862027575 a2025 TP53_mut 1143 HG-5-88-01 EGFR, ADCK4 23 3 2.30258509299405 NA 4.43826766506846 5.26861564482828 -0.830347979759821 0.99568845385248 0.0487469751497171 0.870930764529566 0.83394356592875 17.0338359910449 0.168813817979969 NA NA NA 0.000627431386661613 96.4229862027575 a2026 gain_cnaBRCA19 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 4 44 2.07944154167984 NA 2.44791261401472 3.28397534507095 -0.836062731056235 1.37510605545053 1.12808420643657 0.729664015415037 0.607998726892606 0.74113503786851 0.169056986638408 NA NA NA 0.314238516622134 96.4229862027575 a2027 gain_cnaBRCA48 1378 Bleomycin (50 uM) DNA damage 5 43 3.91202300542815 NA 2.71212011571778 3.94069406636283 -1.22857395064505 0.903681727327378 1.92778879037385 0.660083103145895 1.35952062932437 0.637296967790129 0.169116032027019 NA NA NA 0.0359532029859576 96.4229862027575 a2028 gain_cnaBRCA10_(MDM2,NUP107) 207 AS601245 JNK 4 44 2.07944154167984 NA 3.11292778185382 2.18922552508656 0.923702256767268 1.28316394390195 1.26546315464564 0.729262558464626 0.719863008274999 0.729932162288775 0.169286812222159 NA NA NA 0.248060663883138 96.4229862027575 a2029 loss_cnaBRCA18 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 12 30 -1.38629436111989 0.693147180559945 0.268031498156252 -0.530345635600884 0.798377133757136 1.15220462160946 1.82870891917801 0.478009204900438 0.692912629218513 0.43657966852155 0.169380467678193 NA NA NA 0.0999635569440581 96.4229862027575 a2030 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 38 1.38629436111989 0.693147180559945 2.74899940100336 3.50547509399148 -0.756475692988121 1.03354261014467 1.0280298625341 0.735553360455306 0.731925017471926 0.73584992086067 0.169429890321246 NA NA NA 0.242337064319965 96.4229862027575 a2031 loss_cnaBRCA28_(GPS2) 1259 BMN-673 PARP1 4 42 2.30258509299405 NA 4.33016698056152 3.20795433191898 1.12221264864254 1.46357782793528 1.54078788486921 0.730775192603662 0.766759804106685 0.728336885085127 0.169551395439089 NA NA NA 0.224724425224822 96.4229862027575 a2032 gain_cnaBRCA16 345 KIN001-270 CDK9 16 33 2.99573227355399 NA 5.30258547117427 5.01304226914751 0.289543202026759 0.810880274571412 0.611452445939053 0.424880244391734 0.357072691378263 0.47353347582425 0.169659086917399 NA NA NA 0.218385172520645 96.4229862027575 a2033 gain_cnaBRCA47_(EGFR) 282 EKB-569 EGFR 7 40 0.916290731874155 2.99573227355399 0.562626486158321 1.75576962109364 -1.19314313493532 1.90327946527076 2.11452670879647 0.57153932818804 0.626888040724795 0.564260139146894 0.169861561343632 NA NA NA 0.167539164142263 96.4229862027575 a2034 gain_cnaBRCA30_(CRNKL1,FOXA2) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 5 40 2.30258509299405 NA 2.00477664676023 1.28539243640212 0.719384210358103 0.940070357970558 1.10085066539152 0.661869029469652 0.765245073689084 0.653480288447891 0.170077586633037 NA NA NA 0.169687990644158 96.4229862027575 a2035 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 136 Mitomycin C DNA crosslinker 9 39 2.77258872223978 NA 0.476662966856585 -0.275297959387641 0.751960926244226 0.927484026092442 1.5482084326268 0.515272244663668 0.810753506356646 0.485697474834441 0.17020138153272 NA NA NA 0.072388065022598 96.4229862027575 a2036 gain_cnaBRCA64_(SDHC) 203 BMS-345541 IKBKB 8 41 2.77258872223978 NA 3.08397232684185 3.6198169880902 -0.535844661248349 1.19346006986156 0.956473779607489 0.538346846596131 0.44898415521393 0.560229326378654 0.170222217380443 NA NA NA 0.262374850659728 96.4229862027575 a2037 gain_cnaBRCA31 1019 Bosutinib SRC, ABL, TEC 14 31 0.693147180559945 NA 2.94753011290872 2.53391976123313 0.413610351675587 0.851361149809448 0.949698430650459 0.449051053709063 0.48582244065067 0.435517568868994 0.170314771752039 NA NA NA 0.156974348247889 96.4229862027575 a2038 gain_cnaBRCA58_(CCND1) 1241 CHIR-99021 GSK3B 9 37 2.30258509299405 NA 4.63336922320245 4.1337319796102 0.499637243592248 0.667579186696212 1.01862425936267 0.518107729712937 0.748431427386026 0.490502006996042 0.17031758903744 NA NA NA 0.0893270951435942 96.4229862027575 a2039 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1023 GW 441756 NTRK1 17 28 0.693147180559945 NA 2.70172785641258 2.15137614397315 0.550351712439428 1.68420959532783 0.97097855261676 0.428779007569443 0.326771509891737 0.566801100761954 0.170318230698715 NA NA NA 0.231733963029468 96.4229862027575 a2040 loss_cnaBRCA57 1377 Afatinib (rescreen) ERBB2, EGFR 5 42 2.30258509299405 NA 3.99007101508505 2.69708883415956 1.29298218092549 1.4528726997743 2.00439513483286 0.659126541706547 0.889948707224212 0.645073497962418 0.170388084590995 NA NA NA 0.122591490051779 96.4229862027575 a2041 loss_cnaBRCA36_(FAT1,IRF2) 167 OSU-03012 PDPK1 (PDK1) 9 39 2.77258872223978 NA 1.75894761602954 2.36083243025079 -0.601884814221256 1.04455911522085 1.19314264755388 0.515021395247868 0.576209431760117 0.504453357237049 0.170405231813054 NA NA NA 0.153072842971266 96.4229862027575 a2042 gain_cnaBRCA61_(NOTCH2) 186 Bexarotene Retinioic acid X family agonist 3 44 2.07944154167984 NA 4.47976657803998 3.54472174978737 0.935044828252613 0.577910349142501 1.14406900720329 0.831170856416343 1.61797557292411 0.817297577650808 0.170485593284906 NA NA NA 0.083221315059722 96.4229862027575 a2043 loss_cnaBRCA33 193 GW-2580 CSF1R (cFMS) 6 42 2.99573227355399 NA 5.07205726419383 5.51929338228989 -0.447236118096061 0.674469516595868 0.743245228013891 0.607590938944217 0.663093152605795 0.601734261101374 0.170566531912902 NA NA NA 0.178313362877881 96.4229862027575 a2044 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 6 37 0.693147180559945 NA 3.40586476501985 2.82775176300191 0.57811300201794 1.25617683243408 0.889444112056557 0.61380958455404 0.460216258643884 0.64997113835656 0.170622069718925 NA NA NA 0.321034616142169 96.4229862027575 a2045 gain_cnaBRCA19 277 ABT-869 VEGFR and PDGFR family 4 44 0.0237165266173161 NA 2.37839868262757 2.71950366295172 -0.341104980324149 0.30830311940036 0.478476867259203 0.726894386909852 1.10639483955786 0.712897537300091 0.170647467870622 NA NA NA 0.108517169174116 96.4229862027575 a2046 gain_cnaBRCA63 255 CP724714 ERBB2 7 41 2.32630161961136 NA 3.00273064413097 3.93967313125911 -0.936942487128137 2.34224093990884 1.51539398457074 0.568893531718157 0.400019686772533 0.618283097773771 0.170894197017315 NA NA NA 0.341154076568642 96.4229862027575 a2047 loss_cnaBRCA38 299 OSI-027 MTORC1/2 4 44 2.99573227355399 NA -0.0349651120773433 1.38750907960388 -1.42247419168122 1.29978647980237 1.99711715360118 0.72604135277363 1.09439066630198 0.712263769361868 0.171139654583398 NA NA NA 0.111375849919107 96.4229862027575 a2048 gain_cnaBRCA63 344 THZ-2-49 CDK9 7 42 2.99573227355399 NA 2.49279307435508 1.66735531554529 0.825437758809798 1.55528099417233 1.43996205191654 0.567236104916192 0.530732235462744 0.573235772228282 0.171246886883239 NA NA NA 0.226273407960274 96.4229862027575 a2049 gain_cnaBRCA13_(FGFR1,WHSC1L1) 312 AV-951 VEGFR 11 37 -2.05572501506252 NA 0.865263884564871 0.563009134967439 0.302254749597432 0.61810947635241 0.637502749136829 0.47724132401992 0.488998731067996 0.474123052812997 0.17131586718595 NA NA NA 0.175672464794473 96.4229862027575 a2050 loss_cnaBRCA7_(FAS,PTEN) 281 CH5424802 ALK 4 44 1.63315443905142 NA 4.27453523898216 3.51166729759869 0.762867941383469 0.500746689836771 1.07919727565464 0.725697762424449 1.52346077740852 0.706884606357733 0.171338210477176 NA NA NA 0.0432439288128871 96.4229862027575 a2051 gain_cnaBRCA31 291 KIN001-266 MAP3K8 (COT) 16 33 2.99573227355399 NA 4.11060886368359 3.6176770975815 0.492931766102096 1.40894109748083 1.030961065944 0.423119607041379 0.349859740044104 0.478128401144559 0.171399026454042 NA NA NA 0.224939335868236 96.4229862027575 a2052 MLL3_mut 272 AR-42 HDAC 3 46 1.63315443905142 NA -1.03167774755778 0.218510774734455 -1.25018852229223 0.693506965022914 1.53698886524697 0.827544645017087 1.80270507052647 0.813401157653373 0.171446524521244 NA NA NA 0.0619893511095918 96.4229862027575 a2053 loss_cnaBRCA29_(MAP2K4) 235 QL-XII-47 BTK, BMX 7 42 2.32630161961136 NA 0.986351471260385 1.828362365414 -0.842010894153611 1.13962136591285 1.52921143613897 0.566942773950074 0.738851446049493 0.550617706783284 0.171464009245147 NA NA NA 0.117190724809105 96.4229862027575 a2054 TP53_mut 1248 FK866 NAMPT 34 10 0 NA -0.346389515227382 -1.68538147783778 1.3389919626104 2.35473428813386 3.6158936472301 0.500463283579179 0.56863824056835 0.370307341211797 0.171494975829864 NA NA NA 0.292401513227177 96.4229862027575 a2055 NF1_mut 291 KIN001-266 MAP3K8 (COT) 5 44 2.99573227355399 NA 4.46415197626416 3.70073468540468 0.763417290859476 0.679049500081575 1.2002523728803 0.655289160889174 1.1242439480005 0.636047308140263 0.171530298856928 NA NA NA 0.0662683030769449 96.4229862027575 a2056 loss_cnaBRCA7_(FAS,PTEN) 170 Shikonin unknown 4 43 2.77258872223978 NA 0.781718858972922 -0.0687743977137037 0.850493256686626 0.622536228823595 1.20063639333757 0.72629081195699 1.36617471772494 0.708368712964294 0.171549466005856 NA NA NA 0.0614516458438947 96.4229862027575 a2057 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 135 Gemcitabine DNA replication 9 38 0.0237165266173161 NA 0.860355632283946 -0.544176736528586 1.40453236881253 2.16647863512667 2.83357771962091 0.515058825741334 0.6483019707833 0.495674552734851 0.171554187304491 NA NA NA 0.121306787774459 96.4229862027575 a2058 gain_cnaBRCA14_(RAD21) 56 WH-4-023 SRC family, ABL 6 6 1.63315443905142 NA 2.77527658901069 3.67129202754999 -0.896015438539301 1.32467897067568 0.682723363558805 0.850290642620254 0.676401949735997 1.31241361635652 0.17158250562214 NA NA NA 0.181600550228385 96.4229862027575 a2059 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 274 PXD101, Belinostat HDAC 6 42 2.99573227355399 NA -0.111283068235363 0.783329976566043 -0.894613044801406 0.869528007134241 1.53413436804846 0.605918398640302 1.02884902781894 0.583138650325282 0.171722580277366 NA NA NA 0.0619113950922397 96.4229862027575 a2060 BRCA1_mut 1219 PFI-1 BRD2, BRD3, BRD4 4 43 2.30258509299405 NA 3.82655754446827 3.11163673852709 0.714920805941175 0.856185768170263 0.993327735594743 0.725970589235654 0.835006645192219 0.719722988015758 0.171734525718444 NA NA NA 0.194334628344699 96.4229862027575 a2061 gain_cnaBRCA63 1175 AG-014699 PARP1, PARP2 6 37 1.6094379124341 NA 4.39438875606182 3.77516771220019 0.619221043861626 1.27364192429633 0.969618872592413 0.612121255749364 0.486181423561208 0.638623134681828 0.171774442051505 NA NA NA 0.298444987208924 96.4229862027575 a2062 gain_cnaBRCA8_(CHD4,WNK1) 1020 Lenalidomide TNFA 3 42 1.6094379124341 NA 3.71180571907859 4.29350663815597 -0.581700919077376 0.562558933442263 0.70654473862962 0.830403076975115 1.03402663169525 0.823303730497824 0.171824943313121 NA NA NA 0.207095028418145 96.4229862027575 a2063 BRCA2_mut 211 TL-2-105 CRAF 6 43 2.32630161961136 1.63315443905142 3.33736048684781 3.9871155853111 -0.649755098463297 1.55903734503217 1.00144592758541 0.604645155412283 0.416766859712323 0.648816956128546 0.17185324707533 NA NA NA 0.361866125110287 96.4229862027575 a2064 gain_cnaBRCA14_(RAD21) 119 Lapatinib ERBB2, EGFR 6 7 0.693147180559945 NA 0.51156793352805 2.23994358277393 -1.72837564924588 2.61561779425771 1.60833838682499 0.812895789585111 0.660790599085359 1.07463433280222 0.171949743359891 NA NA NA 0.196899925244645 96.4229862027575 a2065 gain_cnaBRCA31 328 SNX-2112 HSP90 16 32 0.940007258491471 NA 0.987566598938236 0.132076635669971 0.855489963268265 1.97252485261844 2.03323619254773 0.424847489663576 0.433703008675728 0.420752869934064 0.171960848526379 NA NA NA 0.170885128879234 96.4229862027575 a2066 loss_cnaBRCA22_(SYNCRIP,ZNF292) 11 Paclitaxel Microtubules 3 9 -2.27886856637673 NA -4.32703750964951 -2.68325980975746 -1.64377769989205 1.37470926197699 1.74360665213049 0.980578738123354 1.1957275224349 0.942745714971631 0.172079731032195 NA NA NA 0.163472790022481 96.4429431569112 a2067 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 288 KIN001-055 JAK3, MNK1 6 43 2.32630161961136 NA 4.78677034499395 4.27652838189935 0.510241963094598 0.59147277046368 0.869736154748832 0.604191904936653 0.862663487779157 0.58666293255562 0.17216845839852 NA NA NA 0.0994649912960892 96.4459883791225 a2068 gain_cnaBRCA30_(CRNKL1,FOXA2) 193 GW-2580 CSF1R (cFMS) 5 43 2.99573227355399 NA 5.89529272997137 5.41316748817399 0.48212524179738 1.08127657198795 0.694464657874772 0.6548718943457 0.445885219644577 0.694240140704638 0.172437462458188 NA NA NA 0.38062201512336 96.5208205925738 a2069 loss_cnaBRCA57 156 AZD6482 PI3Kbeta 5 42 1.63315443905142 NA 1.208272099269 2.15390952845747 -0.94563742918847 2.19851266068763 1.34645130798106 0.65545750739293 0.430125987490427 0.702318326391179 0.172730099363575 NA NA NA 0.395809101096937 96.5208205925738 a2070 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1248 FK866 NAMPT 13 31 0 NA 0.213318677341701 -1.01303874521132 1.22635742255302 2.39808329565753 2.77920523969174 0.45830435661009 0.51139066969597 0.441261913671782 0.172755499887736 NA NA NA 0.152282901578033 96.5208205925738 a2071 loss_cnaBRCA28_(GPS2) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 4 43 2.32630161961136 NA 0.414854490149869 1.51015318639638 -1.09529869624652 0.710986569562667 1.55418620905437 0.724084405748149 1.54053359533956 0.704740969817856 0.172827703944166 NA NA NA 0.0416448505187017 96.5208205925738 a2072 gain_cnaBRCA14_(RAD21) 268 YM155 BIRC5 (Survivin) 21 28 1.63315443905142 NA -3.95587437661209 -3.32535572100035 -0.63051865561174 1.33023402779263 1.73940608941253 0.399489876297216 0.473990773381441 0.36249077167753 0.172934249521335 NA NA NA 0.157129884480875 96.5208205925738 a2073 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 127 GSK269962A ROCK1, ROCK2 5 9 0.916290731874155 NA 3.01422652064489 2.16465721040877 0.849569310236119 0.572923289765119 1.22207821245337 0.808174491630182 1.48286747181183 0.695184073800461 0.17298114131986 NA NA NA 0.103190750114686 96.5208205925738 a2074 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1264 SGC0946 Q8TEK3 (DOT1L) 6 40 -0.693147180559945 NA 2.26641846387418 1.90335794323815 0.363060520636033 0.621430065203345 0.595902078990059 0.606254982636591 0.584233916196559 0.609262047300375 0.173100640264797 NA NA NA 0.224990649087113 96.5208205925738 a2075 loss_cnaBRCA36_(FAT1,IRF2) 326 GSK690693 AKT 9 39 2.32630161961136 NA 3.73148868307359 2.7568296891484 0.974658993925187 1.51226061017197 1.97797246056041 0.511585194319402 0.644504649112267 0.492756604735053 0.173216680781409 NA NA NA 0.122303801086363 96.5208205925738 a2076 loss_cnaBRCA20 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 3 40 0.693147180559945 NA 3.63541298160339 2.85389412190949 0.781518859693904 0.282786471914222 0.963845870600404 0.829535622911047 2.76363594907384 0.810833851689457 0.173308904571316 NA NA NA 0.0106293772516716 96.5208205925738 a2077 gain_cnaBRCA30_(CRNKL1,FOXA2) 291 KIN001-266 MAP3K8 (COT) 5 44 2.99573227355399 NA 4.46136079155468 3.70105186548531 0.760308926069369 1.66605848136439 1.1071516152926 0.652512304816051 0.456351883546566 0.686725210501936 0.173316865693696 NA NA NA 0.37081492994687 96.5208205925738 a2078 gain_cnaBRCA10_(MDM2,NUP107) 203 BMS-345541 IKBKB 5 44 2.77258872223978 NA 4.11570504000461 3.46603977105477 0.649665268949837 0.673641718002002 1.02044180734095 0.652509632698739 0.964407713460386 0.636650972428031 0.173318591761325 NA NA NA 0.100743181846057 96.5208205925738 a2079 gain_cnaBRCA62 1161 ZG-10 IRAK1 4 22 2.30258509299405 NA 2.85782705923536 1.81497124004107 1.04285581919428 1.82966459534895 1.28784026938573 0.762677969877751 0.569971032857742 0.809771090394386 0.173385704147641 NA NA NA 0.343217772752865 96.5208205925738 a2080 gain_cnaBRCA63 1161 ZG-10 IRAK1 4 22 2.30258509299405 NA 2.85782705923536 1.81497124004107 1.04285581919428 1.82966459534895 1.28784026938573 0.762677969877751 0.569971032857742 0.809771090394386 0.173385704147641 NA NA NA 0.343217772752865 96.5208205925738 a2081 gain_cnaBRCA47_(EGFR) 1003 Camptothecin TOP1 7 38 -2.30258509299405 NA -3.28201073504308 -2.39062078515846 -0.891389949884621 1.25708969645699 1.61151241542586 0.568895476011653 0.709090172639975 0.553138741812958 0.173761148875047 NA NA NA 0.131163387365792 96.5848267737861 a2082 loss_cnaBRCA34 281 CH5424802 ALK 5 43 1.63315443905142 NA 4.18998381261033 3.50375774388882 0.686226068721504 0.373154560425067 1.09436379099152 0.65263222487803 1.83898615077841 0.627054800579398 0.173880336431494 NA NA NA 0.0110643156488075 96.5848267737861 a2083 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1248 FK866 NAMPT 5 39 0 NA 0.907938635361353 -0.850532089049118 1.75847072441047 1.87848428469574 2.74669641892317 0.657084210148013 0.936111490916888 0.640212989064103 0.17388655397738 NA NA NA 0.109724672212116 96.5848267737861 a2084 loss_cnaBRCA36_(FAT1,IRF2) 238 CAL-101 PI3Kdelta 9 40 2.99573227355399 2.32630161961136 5.10716706583786 4.63161857899071 0.475548486847148 0.600853065026475 0.988267567091261 0.50929106284214 0.791455539677066 0.481194063918151 0.173979935499998 NA NA NA 0.0764840362419105 96.5848267737861 a2085 CDH1_mut 1011 ABT-263 BCL2, BCL2L1, BCL2L2 4 39 0.693147180559945 NA 2.76656367319642 1.57070428815696 1.19585938503945 0.982996468078995 1.68874740756918 0.725910947900758 1.21654494585972 0.708133957558994 0.174258182440517 NA NA NA 0.0856176108903647 96.5848267737861 a2086 loss_cnaBRCA7_(FAS,PTEN) 258 STF-62247 stimulates autophagy 4 45 2.32630161961136 NA 5.25840211258229 4.5750598647421 0.683342247840193 0.124693967104222 0.980722382026405 0.719739874996059 5.48015484397126 0.69677439850842 0.17427691697094 NA NA NA 0.000101743244488002 96.5848267737861 a2087 PTEN_mut 1264 SGC0946 Q8TEK3 (DOT1L) 8 38 -0.693147180559945 NA 1.68502548423396 2.00664801681314 -0.321622532579185 0.756790215490742 0.564124245830686 0.536990028962403 0.424982413878896 0.570127121739979 0.174417955984091 NA NA NA 0.285708748468249 96.5848267737861 a2088 gain_cnaBRCA62 1243 piperlongumine Increases ROS levels 8 39 2.30258509299405 NA 2.08468494927125 1.6334394236338 0.451245525637443 1.05088065383297 0.798243325936712 0.535582195570659 0.429397500079171 0.565298212932656 0.174428665738148 NA NA NA 0.281265467530449 96.5848267737861 a2089 gain_cnaBRCA14_(RAD21) 1049 PD-173074 FGFR1, FGFR3 19 24 0.693147180559945 NA 3.20456584707666 2.72654585296707 0.478019994109592 0.925309201245751 1.26183131052452 0.424326700418601 0.516605685392547 0.378830347703836 0.174513119286049 NA NA NA 0.159713567984743 96.5848267737861 a2090 loss_cnaBRCA18 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 15 33 2.32630161961136 NA 4.75562394829867 5.05070242855832 -0.295078480259654 0.547889602906283 0.739778536032745 0.429470941560973 0.538572877992956 0.398874076344645 0.174513372813205 NA NA NA 0.131702341789291 96.5848267737861 a2091 gain_cnaBRCA48 329 QL-XI-92 DDR1 5 43 2.32630161961136 NA 4.79886411890202 4.18990149113343 0.608962627768598 0.245863657201066 0.975274086553944 0.651490174581135 2.47683059261822 0.62440152585241 0.174619662786755 NA NA NA 0.00303620651131061 96.5848267737861 a2092 loss_cnaBRCA42 231 FMK RSK 3 46 2.99573227355399 2.32630161961136 5.13746501167646 5.6186926116517 -0.481227599975233 0.241959313920531 0.59680062840098 0.821075981630085 1.9888781802931 0.806345665661572 0.174752603635016 NA NA NA 0.045185842656895 96.5848267737861 a2093 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 17 28 0.693147180559945 NA 0.99936774261686 0.398619638625719 0.600748103991141 1.46215185007597 1.3885273195792 0.42414641289479 0.410865741448078 0.432651266935964 0.174881407107951 NA NA NA 0.182625565250966 96.5848267737861 a2094 gain_cnaBRCA14_(RAD21) 254 AC220 FLT3 21 27 0.0237165266173161 NA 2.02712043538031 2.37670525639574 -0.349584821015435 1.12863771781015 0.604891052744817 0.400831153107293 0.309740508844343 0.577930223019704 0.174983692913242 NA NA NA 0.209614414358466 96.5848267737861 a2095 gain_cnaBRCA15 200 LAQ824 HDAC 22 26 0.0237165266173161 NA -2.98558169721361 -2.42967839753 -0.555903299683614 0.945148360243859 1.67934011153581 0.399061664765735 0.588165121018868 0.331024844738105 0.174998268572731 NA NA NA 0.157618062919575 96.5848267737861 a2096 loss_cnaBRCA57 230 GSK429286A ROCK2 5 44 2.99573227355399 2.32630161961136 5.92232849528477 5.34677348268943 0.575555012595347 0.480076959789957 0.914655235798769 0.649605040862376 1.19888072288902 0.629258971105888 0.175202679814479 NA NA NA 0.0546787190628243 96.5848267737861 a2097 gain_cnaBRCA27_(CLTC,PPM1D) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 10 37 -2.30258509299405 NA 0.25496399679892 -0.247516574772651 0.502480571571571 0.858296792713486 1.06122987220835 0.490767866308389 0.585439181221906 0.473488906344054 0.175329905644555 NA NA NA 0.137559170931491 96.5848267737861 a2098 PIK3CA_mut 1058 GDC0941 PI3K (class 1) 15 28 1.38629436111989 0.693147180559945 0.953643758154013 1.55619478993371 -0.602551031779693 1.24745720066637 1.42512993106883 0.440764169501916 0.483023410709256 0.422804278152931 0.175826318509484 NA NA NA 0.160876551338015 96.5848267737861 a2099 TP53_mut 1175 AG-014699 PARP1, PARP2 34 9 1.6094379124341 NA 3.97094500696434 3.44837862788784 0.522566379076492 0.824362038927634 1.56392996097767 0.516351415670239 0.633903981988628 0.334136689055957 0.175850483749786 NA NA NA 0.3580346626891 96.5848267737861 a2100 gain_cnaBRCA48 1129 PF-4708671 RPS6KB1 (p70S6KA) 5 38 2.30258509299405 NA 4.46263576031704 3.72295786585034 0.739677894466703 0.61552614675841 1.17092490576873 0.655258431870137 1.20170020130278 0.631703955413858 0.175866696630011 NA NA NA 0.0559776955973733 96.5848267737861 a2101 loss_cnaBRCA33 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 5 42 2.99573227355399 NA 3.02830001429451 3.94520549623355 -0.916905481939046 1.48605687689642 1.40164108920208 0.650587733667778 0.617005645069234 0.654165669801404 0.175876897877976 NA NA NA 0.247784519311115 96.5848267737861 a2102 gain_cnaBRCA31 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 13 30 0.693147180559945 NA 2.60776567382927 3.03870166871363 -0.430935994884361 1.38847381457631 0.676623160437763 0.457286123806905 0.310366670484067 0.636892172898062 0.175933913224128 NA NA NA 0.304006322107726 96.5848267737861 a2103 gain_cnaBRCA8_(CHD4,WNK1) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 4 43 2.32630161961136 NA 0.42194658930974 1.50949345624198 -1.08754686693224 1.70367552430467 1.49858408649244 0.718743704368923 0.638353284658535 0.725716278942833 0.175952195554355 NA NA NA 0.294973674497876 96.5848267737861 a2104 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1527 GDC0941 (rescreen) PI3K 9 36 1.38629436111989 NA 1.44829600393347 0.863745800721151 0.584550203212319 1.4616275511978 1.05370105830567 0.512451427263169 0.39993102396933 0.554759054861598 0.176238115608695 NA NA NA 0.284931638639605 96.5848267737861 a2105 gain_cnaBRCA15 37 Crizotinib MET, ALK 6 8 0.693147180559945 NA 2.32255523080024 2.89959542085899 -0.577040190058746 0.820041832293903 0.683600297942534 0.776113140888737 0.703671651048083 0.844119278173945 0.176253365475893 NA NA NA 0.193432169331613 96.5848267737861 a2106 NF1_mut 260 NG-25 MAP3K7 (TAK1) 5 44 2.32630161961136 NA 3.94677987538291 3.12443016936765 0.82234970601526 1.17451556001544 1.27805436572614 0.647738085776418 0.700160759048991 0.643438751956401 0.176421998813198 NA NA NA 0.20000522631834 96.5848267737861 a2107 gain_cnaBRCA47_(EGFR) 1032 Afatinib ERBB2, EGFR 7 38 -0.693147180559945 NA -0.572303287123205 0.449403932569572 -1.02170721969278 1.45375603572246 1.85842455272967 0.56528911050139 0.702805143770241 0.549770620600167 0.176446491895697 NA NA NA 0.1340868987536 96.5848267737861 a2108 BRCA2_mut 1001 AICAR AAPK1 (AMPK) agonist 5 40 7.60090245954208 NA 8.52754609625542 7.63985044563026 0.88769565062516 0.968406766676091 1.39653008970812 0.651571441367172 0.916655770252453 0.635643769630982 0.176675072605291 NA NA NA 0.115239064902462 96.5848267737861 a2109 loss_cnaBRCA7_(FAS,PTEN) 1166 QL-VIII-58 MTOR, ATR 3 23 2.30258509299405 NA -0.691619455688891 -1.62694980626417 0.935330350575284 0.221169292863056 1.14167889475197 0.854231844977163 4.22902446568125 0.819258685497981 0.176809215971659 NA NA NA 0.00259389428014994 96.5848267737861 a2110 loss_cnaBRCA38 1053 MK-2206 AKT1, AKT2 3 39 1.38629436111989 0.693147180559945 2.63399867828572 1.29848523550325 1.33551344278247 2.75340479926672 1.53876317823397 0.823753386793318 0.485040718726914 0.867913569595052 0.176821005513958 NA NA NA 0.490227033023819 96.5848267737861 a2111 MLL3_mut 172 Embelin XIAP 3 45 3.46573590279973 NA 2.26050143047843 3.04189956308448 -0.781398132606058 0.470493053998005 0.972131851375899 0.817523030083085 1.66080694702322 0.80379850891637 0.177018580606781 NA NA NA 0.0775154426837796 96.5848267737861 a2112 gain_cnaBRCA14_(RAD21) 1133 JNJ-26854165 MDM2 20 23 2.30258509299405 NA 3.16202880007536 2.80080445978004 0.361224340295315 0.859481698010012 0.860810953807247 0.419932981492982 0.420281596608364 0.419632601905994 0.177065180302106 NA NA NA 0.177167514169462 96.5848267737861 a2113 gain_cnaBRCA14_(RAD21) 190 Bleomycin DNA damage 21 27 4.15888308335967 NA 2.68623856159948 1.6056351744527 1.08060338714678 2.46445121286039 2.88397914975478 0.398810080177944 0.438476274761621 0.374691816769433 0.177125351340146 NA NA NA 0.168811740397015 96.5848267737861 a2114 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 276 CAY10603 HDAC6 6 43 2.99573227355399 NA 0.662135851804269 1.24717749798666 -0.585041646182388 0.748615160368722 1.00375777708737 0.597116417891194 0.781498528421776 0.582851420469206 0.177147138445492 NA NA NA 0.126474223004787 96.5848267737861 a2115 POLR2B_mut 1007 Docetaxel Microtubules 3 42 -4.38202663467388 NA -3.42213960967914 -4.6705039445163 1.24836433483716 1.96086063061909 1.4983468094648 0.819686991661143 0.636641031669354 0.833161139297964 0.177303355306181 NA NA NA 0.385288559650991 96.5848267737861 a2116 gain_cnaBRCA16 45 Z-LLNle-CHO g-secretase 3 9 0.940007258491471 NA -0.0661457508323079 1.32185611855602 -1.38800186938833 1.12005017311183 1.50435444446893 0.966745708864619 1.23923186899035 0.922656142966578 0.177655247495578 NA NA NA 0.154300184363423 96.5848267737861 a2117 gain_cnaBRCA10_(MDM2,NUP107) 178 BAY 61-3606 SYK 4 44 2.07944154167984 NA 4.13544842073015 3.00123503992674 1.13421338080341 1.26060519351549 1.60701737011016 0.714810822408308 0.899737194989963 0.705787878774241 0.177722266671569 NA NA NA 0.16929821044619 96.5848267737861 a2118 gain_cnaBRCA16 205 BMS-708163 g-secretase 16 32 2.32630161961136 0.940007258491471 4.70927634347381 4.99015610469253 -0.280879761218714 0.851393806234126 0.562756539223036 0.418805788776929 0.329905807585209 0.499114166858919 0.178015793220753 NA NA NA 0.244757794837743 96.5848267737861 a2119 TP53_mut 63 BMS-509744 ITK 9 3 2.32630161961136 NA 3.84221508595452 2.85801615307072 0.984198932883796 1.04891808641867 0.890050500766419 0.965726785725171 0.938299134724769 1.10577875304413 0.178072011107676 NA NA NA 0.187389255455709 96.5848267737861 a2120 gain_cnaBRCA14_(RAD21) 89 Parthenolide NFKB1 6 8 1.6094379124341 NA 2.65892997585793 3.69306738764473 -1.0341374117868 1.59647019542386 1.11951399782335 0.772289924080512 0.647764934635837 0.923737812834372 0.178233331730892 NA NA NA 0.20981040474432 96.5848267737861 a2121 gain_cnaBRCA12_(TERT) 1016 Temsirolimus MTOR 9 35 -1.6094379124341 NA -1.14928709789309 -1.905651952001 0.75636485410791 1.39839614719747 1.49648173230602 0.511644826728081 0.540880247434709 0.505428725108714 0.178282388674501 NA NA NA 0.177145236291084 96.5848267737861 a2122 loss_cnaBRCA17 225 Genentech Cpd 10 AURKA, AURKB 11 38 2.32630161961136 NA 2.43970880351232 3.18548189628565 -0.745773092773338 1.39821609930919 1.64338046531513 0.467751702673205 0.533374700192479 0.453804282400504 0.178386295656248 NA NA NA 0.15148792448771 96.5848267737861 a2123 loss_cnaBRCA17 1199 Tamoxifen ER 9 38 1.6094379124341 NA 4.25477196604819 3.77784349350929 0.476928472538901 0.582055664505034 1.00202058861054 0.506746714906142 0.819386360485762 0.475966739565937 0.17842902546159 NA NA NA 0.0734878055647891 96.5848267737861 a2124 loss_cnaBRCA36_(FAT1,IRF2) 1053 MK-2206 AKT1, AKT2 9 33 1.38629436111989 0.693147180559945 2.05004150450648 1.21492565693714 0.835115847569335 1.51314898766316 1.64752145234642 0.515014660154788 0.551905895835845 0.506892244941608 0.178472247658206 NA NA NA 0.172594932033657 96.5848267737861 a2125 loss_cnaBRCA28_(GPS2) 263 FR-180204 ERK 4 45 2.99573227355399 NA 5.83189585416075 5.3157505813883 0.516145272772448 0.453373739000233 0.739218912330854 0.712561799408882 1.13845427816493 0.698230610936312 0.178528221955835 NA NA NA 0.101242397435472 96.5848267737861 a2126 gain_cnaBRCA62 1264 SGC0946 Q8TEK3 (DOT1L) 8 38 -0.693147180559945 NA 2.21383143894644 1.89532044739999 0.318510991546455 0.707055776056727 0.576511555525698 0.531573301502962 0.450475057742687 0.552479804599957 0.178713769934472 NA NA NA 0.263031726596579 96.5848267737861 a2127 loss_cnaBRCA57 291 KIN001-266 MAP3K8 (COT) 5 44 2.99573227355399 NA 4.45266563567769 3.70203995138042 0.750625684297272 1.2298359601003 1.15966563570795 0.643870632068824 0.610346183271512 0.647277681759564 0.178968610699032 NA NA NA 0.251806638782857 96.5848267737861 a2128 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 265 Tubastatin A HDAC6 15 34 2.99573227355399 NA 4.39170290184383 4.82413740131962 -0.432434499475796 1.0033880174964 1.03074985921289 0.422846009365543 0.43097435083467 0.419533891380799 0.179010461196371 NA NA NA 0.179060913205466 96.5848267737861 a2129 gain_cnaBRCA8_(CHD4,WNK1) 228 KIN001-102 AKT1 4 45 2.32630161961136 NA 1.035248994122 2.02445511614528 -0.989206122023279 1.53136806083933 1.37977962119305 0.711684929098329 0.645962357005866 0.716930520518884 0.179052972705633 NA NA NA 0.290177842131034 96.5848267737861 a2130 BRCA1_mut 304 SB52334 ALK5 4 45 2.99573227355399 NA 5.12375853149786 4.22883692260496 0.894921608892902 0.9879627990981 1.27453585275419 0.71127381653962 0.905825208914613 0.702154911498984 0.179299404550043 NA NA NA 0.167071322843991 96.5848267737861 a2131 loss_cnaBRCA36_(FAT1,IRF2) 154 CHIR-99021 GSK3B 9 38 0.940007258491471 NA 2.90961852192625 3.36207804441336 -0.452459522487112 0.735304600185331 0.925563180265637 0.505710139380752 0.61533617819482 0.488847797896688 0.179301022263354 NA NA NA 0.136752721349947 96.5848267737861 a2132 gain_cnaBRCA16 194 AUY922 HSP90 16 31 -1.36257783450257 NA -1.92124766983803 -2.63761773544509 0.716370065607055 1.88762361223502 1.60758604169197 0.419900555741624 0.379508955579787 0.445618490723571 0.179327939327433 NA NA NA 0.20653581379552 96.5848267737861 a2133 gain_cnaBRCA27_(CLTC,PPM1D) 1053 MK-2206 AKT1, AKT2 10 32 1.38629436111989 0.693147180559945 0.782144656520381 1.58504605169625 -0.802901395175871 1.20728345199612 1.72344124781423 0.495100700628837 0.665047958578705 0.465871056639824 0.179381270328676 NA NA NA 0.114711873382357 96.5848267737861 a2134 loss_cnaBRCA28_(GPS2) 184 BMS-754807 IGF1R 4 44 0.940007258491471 NA 2.70898425044058 1.52849483688345 1.18048941355713 1.30363878841586 1.68011338717129 0.711923795711449 0.905534128047556 0.70262484816257 0.179445527206565 NA NA NA 0.167238953508025 96.5848267737861 a2135 loss_cnaBRCA29_(MAP2K4) 175 PAC-1 CASP3 agonist 7 41 0.940007258491471 NA 1.8262947070778 2.49956740186792 -0.673272694790119 1.55453499473055 1.14675015729505 0.557449728763511 0.433102308453867 0.587113671192538 0.179487942405224 NA NA NA 0.308542508255248 96.5848267737861 a2136 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 165 DMOG Prolyl-4-Hydroxylase 13 33 8.29404964010203 NA 8.05556978008381 7.37868786186125 0.676881918222557 1.6716151200587 1.45269547169016 0.446627480110766 0.404926893816793 0.465948942096602 0.179523610215831 NA NA NA 0.214932156182141 96.5848267737861 a2137 BRCA1_mut 194 AUY922 HSP90 4 43 -1.36257783450257 NA -1.28126480595414 -2.49723379749743 1.2159689915433 1.4961317714295 1.72009394980411 0.712727642737578 0.81274190867659 0.706920102638451 0.179523737293557 NA NA NA 0.203908344433918 96.5848267737861 a2138 POLR2B_mut 193 GW-2580 CSF1R (cFMS) 3 45 2.99573227355399 NA 4.90226931274092 5.50079683784702 -0.598527525106093 0.814586491283158 0.732972851348911 0.812433787120101 0.734762399709424 0.816575298804867 0.179676356012469 NA NA NA 0.330019310073301 96.5848267737861 a2139 loss_cnaBRCA42 306 TG101348 JAK2 3 45 2.32630161961136 NA 2.25965446958321 3.28923789579538 -1.02958342621218 1.18487281004338 1.27119714769289 0.812252214521412 0.868940039373916 0.80993214001524 0.179771742366174 NA NA NA 0.267586662432488 96.5848267737861 a2140 NF1_mut 192 LFM-A13 BTK 5 43 2.77258872223978 NA 4.31901306029959 4.85087210844369 -0.5318590481441 0.947631961856623 0.814163726136385 0.643409855978217 0.561250643237138 0.653258099163958 0.179920006343113 NA NA NA 0.285422691138998 96.5848267737861 a2141 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 276 CAY10603 HDAC6 6 43 2.99573227355399 NA 0.665341705030037 1.24673016962957 -0.581388464599536 0.484018202661047 1.02317710104355 0.593240353004462 1.2011706613577 0.568218800055798 0.179921080561431 NA NA NA 0.0385953581105415 96.5848267737861 a2142 TP53_mut 45 Z-LLNle-CHO g-secretase 9 3 0.940007258491471 NA 1.32017388174178 -0.0610990403895764 1.38127292213136 1.60400676225943 0.190930320220005 0.96108208585777 0.861139089080692 7.23443463845735 0.179982458856917 NA NA NA 0.03324634141797 96.5848267737861 a2143 loss_cnaBRCA18 134 Etoposide TOP2 15 32 2.77258872223978 NA 1.85840477911442 2.76711587713713 -0.908711098022711 1.5708142857221 2.34217159913487 0.426163127110177 0.578496838412045 0.387978019355355 0.180006366924441 NA NA NA 0.124961003780671 96.5848267737861 a2144 ARID1A_mut 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 4 39 -1.38629436111989 0.693147180559945 -2.83054656783132 -2.15794341504888 -0.672603152782438 0.60878906147729 0.960751149593653 0.715931630665748 1.10482135002606 0.700080507909789 0.180121766100889 NA NA NA 0.109240369537028 96.5848267737861 a2145 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1175 AG-014699 PARP1, PARP2 8 35 1.6094379124341 NA 4.30181300897569 3.7609438233135 0.540869185662191 0.647653608221785 1.07231339479851 0.534192521065517 0.835121087562866 0.504394693086736 0.180275838657682 NA NA NA 0.0813249812566574 96.5848267737861 a2146 loss_cnaBRCA17 171 AKT inhibitor VIII AKT1, AKT2, AKT3 10 37 0.940007258491471 NA 1.41607006420197 2.01638536058521 -0.600315296383238 1.33019008022609 1.21365010699093 0.484971524180808 0.451300385792384 0.494636215928521 0.18037933838215 NA NA NA 0.219160872321998 96.5848267737861 a2147 gain_cnaBRCA14_(RAD21) 1091 BMS-536924 IGF1R 21 26 1.38629436111989 NA 3.26198355563459 2.83052113976208 0.431462415872512 1.04897908745238 1.10586910611871 0.399149522790536 0.411316508625916 0.390156858063268 0.180463100042751 NA NA NA 0.178204282730008 96.5848267737861 a2148 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1007 Docetaxel Microtubules 6 39 -4.38202663467388 NA -3.79905592313218 -4.70854484512638 0.909488921994198 2.22411039572648 1.40549351232641 0.596992072887497 0.408922562360994 0.647095780960801 0.180494038498236 NA NA NA 0.370829672883902 96.5848267737861 a2149 gain_cnaBRCA27_(CLTC,PPM1D) 265 Tubastatin A HDAC6 9 40 2.99573227355399 NA 4.27301747816062 4.78597644672697 -0.51295896856635 0.970609284491954 1.03319525781859 0.5015179343147 0.528491718307484 0.496478245215111 0.180514241419611 NA NA NA 0.181539540431037 96.5848267737861 a2150 loss_cnaBRCA36_(FAT1,IRF2) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 9 34 1.6094379124341 NA 2.2995258326113 3.01842654630228 -0.718900713690982 1.1193216728756 1.46931478870292 0.510629194553984 0.642264624291679 0.489276170918834 0.180580589418842 NA NA NA 0.129704202181465 96.5848267737861 a2151 gain_cnaBRCA16 1061 SB590885 BRAF 14 28 1.6094379124341 NA 4.33078834333481 3.8524733729548 0.478314970380008 0.945857832997678 1.12884242384783 0.445856033914385 0.50569435880665 0.423721646418636 0.180784069228397 NA NA NA 0.158323382247138 96.5848267737861 a2152 gain_cnaBRCA62 1020 Lenalidomide TNFA 8 37 1.6094379124341 NA 4.56046923516013 4.18862005617583 0.371849178984299 0.982043700626836 0.632179473174848 0.530354207656659 0.378648301238478 0.588201918541973 0.180852484135439 NA NA NA 0.333869646321169 96.5848267737861 a2153 loss_cnaBRCA18 203 BMS-345541 IKBKB 16 33 2.77258872223978 NA 3.25473591318373 3.66692425804526 -0.412188344861526 0.74993622524139 1.09286472600836 0.413707898591048 0.549631196611219 0.377163188683953 0.180934752212908 NA NA NA 0.13041610291519 96.5848267737861 a2154 gain_cnaBRCA12_(TERT) 255 CP724714 ERBB2 9 39 2.32630161961136 NA 4.47576142072552 3.64779128471822 0.827970136007296 1.00051561505927 1.75470021502945 0.502253030141159 0.827543442146322 0.471858457026175 0.181032786447782 NA NA NA 0.0713463430441772 96.5848267737861 a2155 gain_cnaBRCA62 154 CHIR-99021 GSK3B 9 38 0.940007258491471 NA 3.63983188364615 3.18913277453233 0.450699109113815 0.865932536094936 0.900974327029332 0.503661665773517 0.52047831710576 0.500235240442252 0.18103388210533 NA NA NA 0.187983110072803 96.5848267737861 a2156 MLL3_mut 303 PIK-93 PI4K, PI3K 3 46 2.99573227355399 NA 1.72439031074377 2.86112308372784 -1.13673277298406 1.05310096865697 1.41882515432499 0.808945709916356 1.07941480144468 0.801178897568154 0.181084399454195 NA NA NA 0.193274399718491 96.5848267737861 a2157 loss_cnaBRCA34 1016 Temsirolimus MTOR 5 39 -1.6094379124341 NA -2.5974911893009 -1.64240887832226 -0.955082310978638 2.53171816036244 1.31989101643283 0.645881269735169 0.377246695912592 0.723606948670553 0.181179499563893 NA NA NA 0.450697039966386 96.5848267737861 a2158 loss_cnaBRCA57 326 GSK690693 AKT 5 43 2.32630161961136 NA 4.03517616364516 2.81218314433079 1.22299301931437 1.25520451160891 1.95734633570282 0.641457960901881 0.974337654145892 0.624821983215982 0.181218701324061 NA NA NA 0.0987973081570831 96.5848267737861 a2159 gain_cnaBRCA64_(SDHC) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 8 41 1.63315443905142 NA 4.01039165458195 3.49202572621534 0.518365928366611 1.03246251306602 0.980268201481363 0.524546899833171 0.502067553840054 0.528800105505072 0.181220107889316 NA NA NA 0.22073662389339 96.5848267737861 a2160 loss_cnaBRCA29_(MAP2K4) 1241 CHIR-99021 GSK3B 7 39 2.30258509299405 NA 4.68791117854967 4.14956482062953 0.538346357920142 1.01575081306789 0.957180467936863 0.557654242475567 0.529998451386086 0.562429318141553 0.181221943357123 NA NA NA 0.228912065653192 96.5848267737861 a2161 gain_cnaBRCA13_(FGFR1,WHSC1L1) 127 GSK269962A ROCK1, ROCK2 4 10 0.916290731874155 NA 1.83563476327127 2.72105084438183 -0.885416081110563 1.71839054869006 0.705710487656978 0.839742971915066 0.515258933299838 1.25464492394073 0.181226736599575 NA NA NA 0.383916129574228 96.5848267737861 a2162 gain_cnaBRCA64_(SDHC) 173 FH535 unknown 8 40 3.46573590279973 NA 2.12714333886869 1.46216901646298 0.664974322405702 1.91688110061437 1.10781573812736 0.525765495632346 0.346904313570922 0.600257154253622 0.181238764215461 NA NA NA 0.370070997713179 96.5848267737861 a2163 TP53_mut 303 PIK-93 PI4K, PI3K 38 11 2.99573227355399 NA 2.6449782196513 3.29778731245115 -0.652809092799853 1.37289584857864 1.51889808402508 0.46455637811321 0.475497899914044 0.429791241206854 0.181313455648351 NA NA NA 0.219256486662113 96.5848267737861 a2164 gain_cnaBRCA16 150 Bicalutamide ANDR (androgen receptor) 16 32 0.0237165266173161 NA 2.93321765403643 2.67727278816084 0.255944865875586 0.629453231674383 0.609345603394241 0.41551206909571 0.406614587067505 0.420032350196497 0.181385076089832 NA NA NA 0.189880125570435 96.5848267737861 a2165 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1091 BMS-536924 IGF1R 6 41 1.38629436111989 NA 3.58285570762208 2.94141634283922 0.641439364782866 0.922349169635791 1.09927554897711 0.593349601453609 0.695440930505908 0.583510990833677 0.181402022116156 NA NA NA 0.163580682492758 96.5848267737861 a2166 gain_cnaBRCA58_(CCND1) 1495 AZD-2281 PARP1, PARP2 9 36 2.30258509299405 NA 4.45040492750338 3.88576288931831 0.564642038185074 0.731420808606965 1.18580426967837 0.506236182743112 0.77197972978164 0.476167992157951 0.181429260167967 NA NA NA 0.0871172212445677 96.5848267737861 a2167 gain_cnaBRCA31 192 LFM-A13 BTK 16 32 2.77258872223978 NA 5.02440404260112 4.68100316509245 0.343400877508669 0.901048803977771 0.788283178708186 0.415364266927345 0.381112405890437 0.43563136545857 0.181537407484295 NA NA NA 0.205885581479633 96.5848267737861 a2168 BRCA2_mut 300 CX-5461 RNA Pol I 6 43 2.32630161961136 NA 3.03755665748297 4.03443161448988 -0.996874957006904 2.28907518049164 1.60151416464329 0.590557447010363 0.435492449309943 0.622457783399588 0.181860556048532 NA NA NA 0.343804500360522 96.5848267737861 a2169 BRCA2_mut 1378 Bleomycin (50 uM) DNA damage 6 42 3.91202300542815 NA 2.84810681383942 3.95051915593224 -1.10241234209282 2.66630384963832 1.74039972694144 0.591593769031842 0.413460882278051 0.633424796055441 0.181873013752654 NA NA NA 0.365851730229692 96.5848267737861 a2170 gain_cnaBRCA12_(TERT) 196 Phenformin AAPK1 (AMPK) agonist 9 39 8.29404964010203 NA 7.93062127103266 7.0338727332084 0.896748537824259 0.798903976107498 1.93496798313196 0.500988356207822 1.12247349449115 0.463443605083724 0.182112501417787 NA NA NA 0.0355454976991361 96.5848267737861 a2171 ASH1L_mut 273 CUDC-101 HDAC, EGFR 3 46 1.63315443905142 NA 1.14745246281511 -0.103220313954042 1.25067277676915 0.989533139428229 1.57064308739047 0.806699084182829 1.26390186132808 0.796280699803714 0.182276162894956 NA NA NA 0.14528371498411 96.5848267737861 a2172 TP53_mut 37 Crizotinib MET, ALK 9 5 0.693147180559945 NA 2.86242807975534 2.27404840677507 0.588379672980273 0.737915946734335 0.759312731972163 0.789647910688671 0.797353242715735 0.774884508326464 0.182286503944154 NA NA NA 0.197374148899764 96.5848267737861 a2173 gain_cnaBRCA63 94 TGX221 PI3Kbeta 3 11 2.30258509299405 NA 4.65209726469768 3.5283696610432 1.12372760365447 0.68482460818775 1.29942594945937 0.922063201774875 1.64089839970586 0.864787719624967 0.182307121401293 NA NA NA 0.0858277953832386 96.5848267737861 a2174 gain_cnaBRCA63 1024 CEP-701 FLT3, JAK2, NTRK1, RET 6 39 0.693147180559945 NA 1.35564263149778 0.513249890180002 0.842392741317776 1.72374986397159 1.37202605482101 0.594315991968459 0.488697785522587 0.613977218842009 0.18241499980559 NA NA NA 0.296613103957611 96.5848267737861 a2175 CDH1_mut 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 4 44 2.07944154167984 NA 3.95778746505492 3.14671399497639 0.811073470078537 1.06776173275356 1.15259069427838 0.70697212159535 0.759601552667493 0.703696007702314 0.182431004599204 NA NA NA 0.22825597471827 96.5848267737861 a2176 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 155 AP-24534 ABL 5 42 -0.669430653942629 NA 0.804130983740828 1.52169652010126 -0.717565536360437 1.48270560550449 1.07920123032628 0.640131763674564 0.48395685137798 0.664904297916238 0.182782505410465 NA NA NA 0.346775080606466 96.5848267737861 a2177 CDH1_mut 1046 681640 WEE1, CHEK1 4 32 0.693147180559945 NA 3.30615893071501 2.54974937771169 0.756409553003316 1.10003509180298 1.04417341929814 0.720924199361936 0.687623111880498 0.72440989113834 0.182972204093609 NA NA NA 0.267329728954318 96.5848267737861 a2178 gain_cnaBRCA47_(EGFR) 1194 SB-505124 TGFR1 (ALK5) 7 40 2.30258509299405 NA 4.81670171152644 4.3141511303458 0.502550581180646 0.59903826006901 0.945446985988294 0.554118896561599 0.838929021199333 0.531548133981643 0.182977207012432 NA NA NA 0.088689412624962 96.5848267737861 a2179 loss_cnaBRCA17 153 Midostaurin KIT 10 37 -0.669430653942629 NA 0.0665545206354515 0.759651508851228 -0.693096988215776 1.04438511196613 1.52045358238045 0.482018560092486 0.663641199280383 0.45584883106438 0.182994357012758 NA NA NA 0.109389965917238 96.5848267737861 a2180 loss_cnaBRCA38 192 LFM-A13 BTK 4 44 2.77258872223978 NA 5.33060753929545 4.74682126834988 0.583786270945574 0.377836345459089 0.849368972218223 0.706032588722842 1.5450770630238 0.687317632313493 0.183001740272363 NA NA NA 0.0412398917979306 96.5848267737861 a2181 gain_cnaBRCA9_(KRAS) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 4 43 2.77258872223978 NA 5.66539830612657 4.95001805750181 0.715380248624754 0.22611031299076 1.04615639947755 0.706640602975555 3.1638550190941 0.683817686324924 0.183193844189018 NA NA NA 0.0014725263791661 96.5848267737861 a2182 gain_cnaBRCA15 1005 Cisplatin DNA crosslinker 21 24 1.79175946922805 2.30258509299405 3.92178509348613 3.44984470242367 0.471940391062463 1.19732745393466 1.14122752811308 0.404177648116657 0.39416150486784 0.413537510651165 0.183241958184193 NA NA NA 0.184885939106804 96.5848267737861 a2183 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 219 AT-7519 CDK9 6 43 2.32630161961136 NA 0.746811708960157 1.80109661421366 -1.05428490525351 1.25078521798843 1.84492353494298 0.5886209864304 0.842898436990686 0.57145181644945 0.183270343827 NA NA NA 0.106364944820582 96.5848267737861 a2184 PIK3CA_mut 293 MP470 PDGFR 16 32 2.99573227355399 NA 3.07698963910507 3.75888294365455 -0.681893304549484 1.94557599054646 1.48590018158269 0.413287036720304 0.350484025225844 0.458909227551997 0.183688676707784 NA NA NA 0.22929778402694 96.5848267737861 a2185 loss_cnaBRCA18 299 OSI-027 MTORC1/2 15 33 2.99573227355399 NA 0.702163900442134 1.52660850144331 -0.824444601001177 1.26484699540421 2.19790288699435 0.420315214680658 0.651813700784979 0.375105108546726 0.183697639527955 NA NA NA 0.108488453440814 96.5848267737861 a2186 loss_cnaBRCA17 136 Mitomycin C DNA crosslinker 11 37 2.77258872223978 NA -0.656312314579235 0.0208859931341311 -0.677198307713366 1.15329537916126 1.53578860670721 0.463459833298066 0.587185485999141 0.440945000344355 0.183765365305483 NA NA NA 0.129552406540576 96.5848267737861 a2187 gain_cnaBRCA16 1052 RO-3306 CDK1 14 29 1.6094379124341 NA 3.87737447080551 3.35588661781993 0.521487852985582 0.833768042714292 1.31702014903988 0.439955127181841 0.625459152029746 0.395960421232546 0.183825809669888 NA NA NA 0.123331009195869 96.5848267737861 a2188 loss_cnaBRCA20 205 BMS-708163 g-secretase 3 45 2.32630161961136 0.940007258491471 4.39053302074459 4.93026261741129 -0.539729596666708 0.593643620739394 0.674334932831976 0.804331958208878 0.909181161577151 0.800388012526695 0.183970457770075 NA NA NA 0.251314206849371 96.5848267737861 a2189 MLL3_mut 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 3 45 2.77258872223978 NA -1.48549313572128 -0.366596139259593 -1.11889699646169 1.24623976267544 1.39754146190817 0.80420666124851 0.897818405392255 0.800618104692201 0.184037478340738 NA NA NA 0.255789032688019 96.5848267737861 a2190 BRCA1_mut 152 CP466722 ATM 4 45 2.77258872223978 NA 3.40766135484195 2.66991779675149 0.737743558090466 1.36243104222555 1.02429196510213 0.703191171237397 0.541490567394407 0.720247334964604 0.184197373182425 NA NA NA 0.361598255360994 96.5848267737861 a2191 NF1_mut 1026 17-AAG HSP90 4 39 0 NA 0.237567373029554 -1.01249116543153 1.25005853846109 1.82886771908899 1.75750686736032 0.709121768750741 0.683515010633889 0.711268081892963 0.184209530989997 NA NA NA 0.268718921972334 96.5848267737861 a2192 gain_cnaBRCA48 272 AR-42 HDAC 5 44 1.63315443905142 NA 1.00569085198725 0.0438183667085304 0.961872485278725 1.49311663799639 1.51425216621972 0.635963510640357 0.644204518790613 0.635212883782762 0.184262927199501 NA NA NA 0.231227790483095 96.5848267737861 a2193 gain_cnaBRCA14_(RAD21) 1017 Olaparib PARP1, PARP2 20 25 1.6094379124341 NA 4.27161074811814 3.91608797757751 0.355522770540635 0.88092526108485 0.87612138832686 0.404809422943436 0.403578812239772 0.405791680556482 0.184282107849321 NA NA NA 0.18493477684508 96.5848267737861 a2194 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1016 Temsirolimus MTOR 7 37 -1.6094379124341 NA -2.44297322857716 -1.62001593516304 -0.82295729341412 2.09563635500983 1.34932636409485 0.556361073956203 0.39270042793768 0.609902330016484 0.18429989822428 NA NA NA 0.350527893867171 96.5848267737861 a2195 PTEN_mut 1022 AZD7762 CHEK1, CHEK2 7 38 0.693147180559945 NA 0.153948659070621 1.04305632208775 -0.889107663017127 1.07604936082842 1.67213821948114 0.554883831482121 0.826270332368978 0.531719000653555 0.184373890381961 NA NA NA 0.0937050775005458 96.5848267737861 a2196 gain_cnaBRCA19 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 4 44 0.246860077931526 2.32630161961136 -1.31867232017723 -0.16915910328939 -1.14951321688784 0.654922300809853 1.68116187125622 0.703496693127022 1.75519021946022 0.683761175257256 0.184549037008861 NA NA NA 0.0256889715816844 96.5848267737861 a2197 loss_cnaBRCA20 165 DMOG Prolyl-4-Hydroxylase 3 43 8.29404964010203 NA 6.42918335633407 7.64957108170951 -1.22038772537544 1.24718322711192 1.52789371016743 0.804866004121124 0.978515184333794 0.798738627729349 0.184607652681059 NA NA NA 0.225512187590393 96.5848267737861 a2198 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 207 AS601245 JNK 6 42 2.07944154167984 NA 1.61388313242901 2.35938893896785 -0.745505806538841 1.27174778600166 1.26802653791199 0.587738302789716 0.586205704263648 0.587926028556497 0.184682049754609 NA NA NA 0.224033586578154 96.5848267737861 a2199 gain_cnaBRCA12_(TERT) 1030 KU-55933 ATM 9 33 2.30258509299405 NA 4.58515111045612 4.1233397853911 0.461811325065027 0.967669292415966 0.894807966063413 0.507570236113685 0.477240859748716 0.516101043553182 0.184689305811094 NA NA NA 0.221597818391482 96.5848267737861 a2200 loss_cnaBRCA38 333 T0901317 LXR 4 44 2.32630161961136 NA 4.24841303320039 4.77971103992328 -0.53129800672289 0.51669092882544 0.769431630913275 0.703212212072951 1.02827043612059 0.690507103395616 0.184723237444056 NA NA NA 0.128584671756247 96.5848267737861 a2201 BRCA1_mut 158 PF-562271 FAK 4 41 0.940007258491471 NA 3.15159219319831 2.2534119628567 0.898180230341608 0.566306005841971 1.31048852481494 0.705690638360618 1.5860333831463 0.685378172592882 0.184974701310743 NA NA NA 0.0378243118016163 96.5848267737861 a2202 loss_cnaBRCA34 165 DMOG Prolyl-4-Hydroxylase 5 41 8.29404964010203 NA 6.70785052452121 7.67511838926597 -0.967267864744763 1.01322016082145 1.55771345959737 0.637906887196119 0.954647274251404 0.620953654078831 0.184988463261472 NA NA NA 0.104710332908612 96.5848267737861 a2203 loss_cnaBRCA33 104 Bortezomib Proteasome 5 9 -3.91202300542815 NA -3.72203119352274 -5.04398298045014 1.3219517869274 2.26562036505377 1.301811028748 0.784320866438416 0.583483361695515 1.01547133780144 0.185038479447397 NA NA NA 0.279419963259987 96.5848267737861 a2204 CDH1_mut 1218 JQ1 BRD2, BRD3, BRD4 5 41 0 NA 2.85220659624187 2.40990568612505 0.442300910116819 0.729193039418056 0.689819047227943 0.637789076005237 0.606562166953491 0.641183962510484 0.185067999854079 NA NA NA 0.255095502666299 96.5848267737861 a2205 BRCA2_mut 1529 MLN4924 NEDD8-activating enzyme 3 34 0 NA -0.882623471528434 0.479671632103685 -1.36229510363212 1.17897287111277 1.69851477135601 0.814196067079874 1.1554931729229 0.802050783782426 0.185095739084705 NA NA NA 0.169787505182293 96.5848267737861 a2206 gain_cnaBRCA30_(CRNKL1,FOXA2) 1248 FK866 NAMPT 5 39 0 NA 0.868521225630278 -0.845478574981031 1.71399980061131 3.46103276900742 2.58319043228833 0.639739496280648 0.495227845271994 0.663520497438881 0.185276343015595 NA NA NA 0.337709257944633 96.5848267737861 a2207 gain_cnaBRCA31 305 TPCA-1 IKK 16 33 2.99573227355399 NA 4.55483660841794 3.99577594492673 0.55906066349121 1.17017293893011 1.4476624322011 0.409495207413537 0.477759008854159 0.38618164777626 0.185332501626292 NA NA NA 0.156256794500752 96.5848267737861 a2208 gain_cnaBRCA15 3 Rapamycin MTOR 6 8 -2.30258509299405 NA -3.83851690440951 -1.92002355709537 -1.91849334731414 3.85016739320332 0.614564727680873 0.758534942950209 0.498288295387064 3.12171079937142 0.185511700712724 NA NA NA 0.278807572004502 96.5848267737861 a2209 gain_cnaBRCA30_(CRNKL1,FOXA2) 312 AV-951 VEGFR 5 43 -2.05572501506252 NA 0.993006133146905 0.590330466471495 0.402675666675409 0.893953335367944 0.603621743278596 0.634968226721847 0.45044372087909 0.667099340206434 0.185588342575734 NA NA NA 0.376799414178144 96.5848267737861 a2210 gain_cnaBRCA30_(CRNKL1,FOXA2) 1053 MK-2206 AKT1, AKT2 4 38 1.38629436111989 0.693147180559945 2.43302071018151 1.28449572049363 1.14852498968789 1.3318163806632 1.64408884252456 0.707762767721191 0.862374878672061 0.698578422273266 0.18574339730949 NA NA NA 0.184059190903885 96.5848267737861 a2211 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1032 Afatinib ERBB2, EGFR 17 28 -0.693147180559945 NA 0.755844512502617 0.00792391840131451 0.747920594101302 1.59404746961583 1.9251412752351 0.413435882684806 0.469195935728034 0.388501666720519 0.185792509221875 NA NA NA 0.166840978948349 96.5848267737861 a2212 gain_cnaBRCA15 56 WH-4-023 SRC family, ABL 6 6 1.63315443905142 NA 2.78846317459354 3.65810544196714 -0.869642267373603 1.34191580071298 0.66939311770819 0.820120733647088 0.64806023366857 1.29915029654175 0.18588501454059 NA NA NA 0.196501939400693 96.5848267737861 a2213 loss_cnaBRCA17 164 JQ12 HDAC 10 37 1.63315443905142 NA 0.966628750851897 1.74308706872804 -0.776458317876147 1.7215434745408 1.59610978562843 0.478712312660393 0.451024519193892 0.486469242195916 0.185956578805002 NA NA NA 0.22048988452444 96.5848267737861 a2214 gain_cnaBRCA15 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 21 25 2.30258509299405 NA 1.62558960222549 1.23474657825545 0.390843023970045 0.845162955854281 1.08472489237656 0.397563147131132 0.462446941459929 0.360315345132105 0.186128295830605 NA NA NA 0.176864368279172 96.5848267737861 a2215 gain_cnaBRCA27_(CLTC,PPM1D) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 10 33 -1.38629436111989 0.693147180559945 -1.87045597676918 -2.32658847547091 0.456132498701734 1.13400504368331 0.877822631191962 0.485217678164597 0.402231455003224 0.519618066900791 0.186279141609335 NA NA NA 0.263850806497005 96.5848267737861 a2216 POLR2B_mut 156 AZD6482 PI3Kbeta 3 44 1.63315443905142 NA 3.13619270726329 1.97947687658566 1.15671583067763 0.661956358528263 1.47084351970373 0.800748464346589 1.74742007652797 0.786430245761716 0.186346604038546 NA NA NA 0.066457970524855 96.5848267737861 a2217 BRCA1_mut 1017 Olaparib PARP1, PARP2 4 41 1.6094379124341 NA 3.51116074100602 4.12901881555552 -0.6178580745495 0.423476885148662 0.903352516982176 0.703373308822556 1.45901251335737 0.683961203333528 0.186392108828606 NA NA NA 0.0501982582685778 96.5848267737861 a2218 PTEN_mut 282 EKB-569 EGFR 9 38 0.916290731874155 2.99573227355399 2.41870908157034 1.37896811875581 1.03974096281453 1.53005828629469 2.19334640930457 0.497278130396405 0.679543369117294 0.474043205580185 0.186516331713185 NA NA NA 0.113027964192355 96.5848267737861 a2219 loss_cnaBRCA42 135 Gemcitabine DNA replication 3 44 0.0237165266173161 NA -2.32121710168535 -0.135724181647152 -2.1854929200382 2.0471737915838 2.75843874635103 0.800322972678481 1.0675658945142 0.792293438790058 0.186576177021328 NA NA NA 0.196452874507532 96.5848267737861 a2220 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 224 AS605240 PI3Kgamma 15 34 2.99573227355399 2.32630161961136 2.81974973387211 3.46900984437611 -0.649260110503999 1.14596765232674 1.70924358003282 0.415437340838474 0.566560591117699 0.379852303140745 0.186600655525942 NA NA NA 0.127111391621973 96.5848267737861 a2221 ASH1L_mut 1058 GDC0941 PI3K (class 1) 3 40 1.38629436111989 0.693147180559945 2.36950984854926 1.26923952362015 1.10027032492911 1.12558219106403 1.37986374930289 0.803964213109162 0.97751220094288 0.797376063749026 0.186642692656826 NA NA NA 0.225557744360235 96.5848267737861 a2222 gain_cnaBRCA62 34 Imatinib ABL, KIT, PDGFR 5 9 0.693147180559945 NA 2.55038492471708 2.90352132812177 -0.353136403404691 0.427323432794118 0.46392293394751 0.781184554226441 0.826391384847902 0.761196262490973 0.186674872935418 NA NA NA 0.184630351521336 96.5848267737861 a2223 loss_cnaBRCA18 222 BX-912 PDPK1 (PDK1) 16 33 2.32630161961136 NA 3.47298266047319 4.08295562563787 -0.609972965164677 1.09518782622569 1.64899469235586 0.408087848316793 0.556957400875068 0.369905960275244 0.186819729291214 NA NA NA 0.131599392202798 96.5848267737861 a2224 BRCA1_mut 135 Gemcitabine DNA replication 4 43 0.0237165266173161 NA 1.47534038514325 -0.438066903211715 1.91340728835497 1.66273453395545 2.79152822057662 0.700668716393484 1.15075933606984 0.685433618134704 0.186850096763412 NA NA NA 0.0987074217214072 96.5848267737861 a2225 PIK3CA_mut 1143 HG-5-88-01 EGFR, ADCK4 10 16 2.30258509299405 NA 4.85632835971799 4.33266997711747 0.523658382600525 1.02606019646954 0.912232778855969 0.547469597049753 0.510358343888911 0.57404030499457 0.18706170341976 NA NA NA 0.203697984508169 96.5848267737861 a2226 loss_cnaBRCA38 203 BMS-345541 IKBKB 4 45 2.77258872223978 NA 2.89286386690304 3.58917377019602 -0.696309903292979 1.03373682529484 0.994292965786973 0.698505101587849 0.673585274563839 0.700306576886881 0.187083524076332 NA NA NA 0.273891010596762 96.5848267737861 a2227 gain_cnaBRCA14_(RAD21) 1264 SGC0946 Q8TEK3 (DOT1L) 20 26 -0.693147180559945 NA 2.08575285537145 1.84683736174393 0.23891549362752 0.599576179259232 0.599728910183587 0.398416291121243 0.398473958593046 0.398372480583575 0.187269026295212 NA NA NA 0.187749130743209 96.5848267737861 a2228 loss_cnaBRCA57 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 5 43 2.32630161961136 NA 5.34820788297634 4.91317441748891 0.435033465487437 0.397386598507673 0.709356398265452 0.632437020928573 1.09473612628393 0.613279116888491 0.187314296088552 NA NA NA 0.0726347155972033 96.5848267737861 a2229 loss_cnaBRCA57 261 TL-1-85 MAP3K7 (TAK1) 5 44 2.32630161961136 NA 4.70423670626404 3.94759848408801 0.756638222176029 1.02888766580395 1.21289065304732 0.631409887073359 0.735394394668741 0.623830532682415 0.187365712970432 NA NA NA 0.183229656022213 96.5848267737861 a2230 gain_cnaBRCA27_(CLTC,PPM1D) 1248 FK866 NAMPT 10 34 0 NA 0.347561443177996 -0.944313903761435 1.29187534693943 2.34402851139665 2.76425964930713 0.482085580573369 0.551134655853519 0.467349493475854 0.187418002056599 NA NA NA 0.160204716140435 96.5848267737861 a2231 gain_cnaBRCA30_(CRNKL1,FOXA2) 200 LAQ824 HDAC 5 43 0.0237165266173161 NA -1.89471586936415 -2.77629898436415 0.881583115 1.47572487271317 1.3866229084498 0.632141880053683 0.597389887031709 0.635777116927619 0.187516338132734 NA NA NA 0.260819358005322 96.5848267737861 a2232 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 305 TPCA-1 IKK 15 34 2.99573227355399 NA 4.57111140200935 4.00503884962144 0.566072552387903 0.95838870350963 1.50530773162441 0.41455384049881 0.590650276150938 0.37605104955984 0.187521947457687 NA NA NA 0.121182011783845 96.5848267737861 a2233 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 140 Vinorelbine Microtubules 9 38 -2.74887219562247 NA -2.94725086992812 -3.75437227920792 0.807121409279795 1.69849035439223 1.61108735938103 0.496089028490863 0.475199289293938 0.500979294871935 0.187551451595885 NA NA NA 0.22059753154874 96.5848267737861 a2234 gain_cnaBRCA64_(SDHC) 1019 Bosutinib SRC, ABL, TEC 9 36 0.693147180559945 NA 2.29424040853477 2.75468806950379 -0.460447660969018 1.35242100901035 0.792311274080656 0.499058168188861 0.340461777731445 0.581144906089202 0.187569800582997 NA NA NA 0.351500980077358 96.5848267737861 a2235 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1028 VX-702 p38 7 38 0.693147180559945 NA 3.1127157032877 3.48469485547905 -0.371979152191353 0.520917779634041 0.697223213197214 0.550761183402292 0.714084192811922 0.533515157198497 0.187589245443774 NA NA NA 0.131158036863767 96.5848267737861 a2236 gain_cnaBRCA14_(RAD21) 41 S-Trityl-L-cysteine KIF11 6 6 1.63315443905142 NA 0.592912878009975 1.85537881720433 -1.26246593919436 1.06319136301567 1.91044161275649 0.816607404146616 1.18743058221754 0.660824141792434 0.18761507585042 NA NA NA 0.195771389336642 96.5848267737861 a2237 TP53_mut 51 Dasatinib ABL, SRC, KIT, PDGFR 9 3 0.246860077931526 NA 2.21812798811024 1.20705819355223 1.01106979455801 1.18183654086157 0.404973486783761 0.942749244030929 0.855507305452686 2.49663206988629 0.187695480519321 NA NA NA 0.0524103185803083 96.5848267737861 a2238 gain_cnaBRCA58_(CCND1) 1175 AG-014699 PARP1, PARP2 6 37 1.6094379124341 NA 4.37538664096358 3.77824913627018 0.5971375046934 0.345223424850109 1.07366700679504 0.589317778729429 1.72971317039876 0.556166391361778 0.187936336260808 NA NA NA 0.014065096888049 96.5848267737861 a2239 loss_cnaBRCA22_(SYNCRIP,ZNF292) 211 TL-2-105 CRAF 19 30 2.32630161961136 1.63315443905142 4.16564181227812 3.744097955206 0.421543857072125 1.24864194297733 0.953512828732885 0.391715889787062 0.337601871731919 0.44209563245448 0.187978283767033 NA NA NA 0.217907923290615 96.5848267737861 a2240 loss_cnaBRCA22_(SYNCRIP,ZNF292) 170 Shikonin unknown 17 30 2.77258872223978 NA 0.307385858065444 -0.168532775097004 0.475918633162448 0.779195144579934 1.3414076537154 0.40579532266374 0.610782339280383 0.354790456014067 0.18803050611718 NA NA NA 0.130943954125875 96.5848267737861 a2241 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1013 Nilotinib ABL 13 27 0.693147180559945 NA 3.49131115408751 3.06404630715129 0.427264846936219 0.704535720676499 1.03656551485732 0.452414390951749 0.606448806493384 0.412192804807934 0.188148674107872 NA NA NA 0.135433402067806 96.5848267737861 a2242 MLL3_mut 1003 Camptothecin TOP1 3 42 -2.30258509299405 NA -1.35972172874439 -2.61282142369261 1.25309969494822 1.66726372676525 1.56415789449786 0.798608563716869 0.751590570125001 0.801133759805306 0.188470967276927 NA NA NA 0.321355900866694 96.5848267737861 a2243 gain_cnaBRCA58_(CCND1) 312 AV-951 VEGFR 10 38 -2.05572501506252 NA 0.870454111040758 0.569597358252664 0.300856752788094 0.325910767553022 0.688779722693241 0.474288301819149 0.923126152127357 0.436796762267762 0.188613486577265 NA NA NA 0.0564834860158593 96.5848267737861 a2244 gain_cnaBRCA48 155 AP-24534 ABL 5 42 -0.669430653942629 NA 0.812434248562204 1.52070803619396 -0.708273787631754 1.24089764756997 1.10922119995865 0.631512235062999 0.570775348812012 0.638532501594952 0.188629908942201 NA NA NA 0.279208145126121 96.5848267737861 a2245 BRCA1_mut 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 4 42 0 NA -0.644963787302457 0.776851234252286 -1.42181502155474 0.829531078333982 2.09631155308507 0.698631002514969 1.71399849709102 0.678246045757037 0.18870066977683 NA NA NA 0.0283954824351675 96.5848267737861 a2246 BRCA1_mut 230 GSK429286A ROCK2 4 45 2.99573227355399 2.32630161961136 5.97222629673484 5.35512823395154 0.617098062783305 0.306748707232425 0.913305357495811 0.695659956456884 2.01173810429697 0.675675509530924 0.188852592395279 NA NA NA 0.014384213536414 96.5848267737861 a2247 gain_cnaBRCA27_(CLTC,PPM1D) 1091 BMS-536924 IGF1R 10 37 1.38629436111989 NA 3.42817331102559 2.91387759978066 0.514295711244933 1.29770006698434 1.02068826487397 0.475416023671624 0.396313234721549 0.503871484510929 0.188946211012719 NA NA NA 0.268281143677294 96.5848267737861 a2248 gain_cnaBRCA64_(SDHC) 186 Bexarotene Retinioic acid X family agonist 8 39 2.07944154167984 NA 4.08826901100775 3.50515140094108 0.583117610066669 1.03944373255619 1.14231535469775 0.517439051670246 0.560990067863195 0.510469904539591 0.189184174426922 NA NA NA 0.183746431840421 96.5848267737861 a2249 MLL3_mut 328 SNX-2112 HSP90 3 45 0.940007258491471 NA -1.08522821288517 0.517404501402364 -1.60263271428754 1.8801268748317 2.02277609479381 0.794647764086577 0.85240668368777 0.792293679173078 0.189205704262845 NA NA NA 0.274468649342988 96.5848267737861 a2250 BRCA1_mut 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 38 -1.38629436111989 0.693147180559945 -1.36504155334169 -0.190363812546966 -1.17467774079473 0.808021488861919 1.72497881212558 0.70183468424334 1.45377042193424 0.680980967729827 0.189374502945283 NA NA NA 0.0511462359910452 96.5848267737861 a2251 loss_cnaBRCA22_(SYNCRIP,ZNF292) 265 Tubastatin A HDAC6 19 30 2.99573227355399 NA 4.93640978971517 4.53681430559788 0.39959548411729 1.03482666404919 1.01656940911636 0.390382448330395 0.386147263111394 0.393082341976662 0.189458186284937 NA NA NA 0.192755735417046 96.5848267737861 a2252 gain_cnaBRCA16 1043 JNK Inhibitor VIII JNK 14 29 2.30258509299405 NA 5.01300937638749 4.69321067314355 0.319798703243932 0.918382408181994 0.634583550552708 0.434211051347681 0.348219543835772 0.503950508905241 0.189493165514813 NA NA NA 0.254523995702251 96.5848267737861 a2253 ASH1L_mut 150 Bicalutamide ANDR (androgen receptor) 3 45 0.0237165266173161 NA 2.30379789002303 2.79317373368135 -0.48937584365832 0.668592054580415 0.613942021734133 0.793901467582181 0.731949834440426 0.797104329617371 0.189613811133375 NA NA NA 0.331463801784604 96.5848267737861 a2254 gain_cnaBRCA10_(MDM2,NUP107) 196 Phenformin AAPK1 (AMPK) agonist 5 43 8.29404964010203 NA 8.21117545449103 7.08466862237131 1.12650683211972 1.05948795535062 1.84576753066203 0.628929273971793 1.06325591190598 0.610318912542402 0.189726323286505 NA NA NA 0.078921388718956 96.5848267737861 a2255 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 38 AZD-0530 SRC, ABL1 4 10 0.693147180559945 NA 2.2192555409679 2.73337176157381 -0.51411622060591 0.696008285848228 0.599629580613469 0.822429525746321 0.738663936995168 0.857389690615209 0.189727824193522 NA NA NA 0.252240302424889 96.5848267737861 a2256 gain_cnaBRCA16 64 CMK RSK 3 9 1.38629436111989 NA 1.40331066552633 2.47110507940191 -1.06779441387558 0.824603044436774 1.20431512231368 0.937855424276732 1.29491932036816 0.886640376834411 0.189801483796122 NA NA NA 0.144833355075922 96.5848267737861 a2257 gain_cnaBRCA48 1009 ATRA Retinoic acid and retinoid X receptor agonist 5 40 2.30258509299405 NA 4.74819501065292 4.02569285420243 0.722502156450494 1.19748658584068 1.13770853413509 0.631888615390209 0.603348851664395 0.635050309260232 0.18983241749705 NA NA NA 0.25763390516061 96.5848267737861 a2258 gain_cnaBRCA58_(CCND1) 1013 Nilotinib ABL 8 32 0.693147180559945 NA 3.60150399823485 3.10325822844824 0.498245769786615 0.538423086397599 1.01403776834201 0.527471214157888 0.925379654725067 0.491348335675174 0.190011578903021 NA NA NA 0.0703930130840176 96.5848267737861 a2259 loss_cnaBRCA57 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 5 41 2.30258509299405 NA 1.96584188757689 1.34577650403017 0.620065383546716 0.525676392781855 1.01796031909494 0.630504462167201 1.17955721820673 0.609125298811263 0.190036972641758 NA NA NA 0.0591203430092787 96.5848267737861 a2260 TP53_mut 1018 ABT-888 PARP1, PARP2 35 10 1.6094379124341 NA 4.47271344106027 4.15934582038776 0.313367620672502 0.624391592536035 0.765236611850292 0.477420611104405 0.501876745969184 0.4095042184597 0.190052694794966 NA NA NA 0.257082822242008 96.5848267737861 a2261 gain_cnaBRCA16 230 GSK429286A ROCK2 16 33 2.99573227355399 2.32630161961136 5.64747758375296 5.28818285983973 0.359294723913229 0.940657852027842 0.860943421324223 0.404993032215911 0.381961117040242 0.417326754597411 0.190122158605043 NA NA NA 0.208318028248524 96.5848267737861 a2262 gain_cnaBRCA47_(EGFR) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 6 40 2.30258509299405 NA 0.915186061190041 1.48787324339953 -0.57268718220949 0.535975106317654 1.02683259372399 0.582312910026618 1.06849586008586 0.557722052951727 0.190340205545541 NA NA NA 0.0581902442806025 96.5848267737861 a2263 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 344 THZ-2-49 CDK9 6 43 2.99573227355399 NA 1.04455307656183 1.88863154218643 -0.844078465624603 1.45662972013412 1.45777376506221 0.579067162281739 0.579473598511283 0.579018833960551 0.190348315262342 NA NA NA 0.228557184307942 96.5848267737861 a2264 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1013 Nilotinib ABL 6 34 0.693147180559945 NA 3.67685424267412 3.1192697011817 0.557584541492418 0.788332051463462 0.966117021146895 0.590262748084585 0.707296551570264 0.577139755627636 0.190468746567663 NA NA NA 0.162427672905946 96.5848267737861 a2265 ASH1L_mut 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 3 45 2.07944154167984 NA 2.36162495979076 3.2711486835513 -0.909523723760542 0.42492975279694 1.17036037301447 0.792227174479073 2.14040960364376 0.777131338972034 0.190531823270856 NA NA NA 0.0337797494598617 96.5848267737861 a2266 CDH1_mut 277 ABT-869 VEGFR and PDGFR family 4 44 0.0237165266173161 NA 2.39229593818847 2.71824027608255 -0.325944337894081 0.259274826645299 0.481397857747379 0.693319239506544 1.25713838906539 0.67707891227286 0.190859610826391 NA NA NA 0.0782304103526844 96.5848267737861 a2267 gain_cnaBRCA30_(CRNKL1,FOXA2) 190 Bleomycin DNA damage 5 43 4.15888308335967 NA 3.60266169905943 1.90115932577942 1.70150237328001 2.55658093717931 2.72729815041863 0.627194190365479 0.665538238408867 0.623878387853868 0.190928120327528 NA NA NA 0.219511692260294 96.5848267737861 a2268 gain_cnaBRCA10_(MDM2,NUP107) 177 GSK-650394 SGK3 4 43 2.77258872223978 NA 5.07905606773468 3.91540464783811 1.16365141989657 1.25632314186029 1.70260531260675 0.69407369330176 0.92623575983286 0.68345341770077 0.190952307872481 NA NA NA 0.16024455626285 96.5848267737861 a2269 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1377 Afatinib (rescreen) ERBB2, EGFR 6 41 2.30258509299405 NA 3.82956369938183 2.68904155887405 1.14052214050779 1.18256028769174 2.0422663259823 0.580299527351415 0.964451582197129 0.558459063834003 0.191002463312999 NA NA NA 0.076783236384819 96.5848267737861 a2270 gain_cnaBRCA13_(FGFR1,WHSC1L1) 193 GW-2580 CSF1R (cFMS) 11 37 2.99573227355399 NA 5.72229240079152 5.38641754682788 0.33587485396364 0.601441442186165 0.770997451000558 0.455447513862575 0.558449801434994 0.435636789107097 0.191315003655953 NA NA NA 0.144058764692153 96.5848267737861 a2271 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 179 5-Fluorouracil DNA antimetabolite 6 43 3.46573590279973 NA 3.23015523854877 4.15468433217096 -0.924529093622188 0.853950610183872 1.66739318080837 0.577603759771915 1.08264937409333 0.554475755486758 0.191450593679204 NA NA NA 0.0546061354527558 96.5848267737861 a2272 gain_cnaBRCA61_(NOTCH2) 260 NG-25 MAP3K7 (TAK1) 3 46 2.32630161961136 NA 2.26584423848482 3.26981074160079 -1.00396650311597 0.614913286576247 1.2926841167376 0.789762632085236 1.63269606468567 0.776652617694197 0.191454348782908 NA NA NA 0.0805346821148557 96.5848267737861 a2273 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1241 CHIR-99021 GSK3B 14 32 2.30258509299405 NA 4.51723299987175 4.10647325800609 0.410759741865665 0.85778978584421 1.00830779828576 0.425093926431699 0.478858280483497 0.407375349634313 0.191480398356026 NA NA NA 0.16785813810437 96.5848267737861 a2274 CDH1_mut 293 MP470 PDGFR 4 44 2.99573227355399 NA 2.48392430467815 3.62682707281623 -1.14290276813809 1.45651267231409 1.66377165928768 0.692228662242957 0.784684397096424 0.686934869793012 0.191545446516522 NA NA NA 0.216597383337611 96.5848267737861 a2275 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 8 34 -1.38629436111989 0.693147180559945 0.405004898620621 -0.468647949385778 0.873652848006399 1.23401746449136 1.75331074479949 0.521863230747901 0.707974459961557 0.498287511553641 0.191688100479927 NA NA NA 0.120629580422429 96.5848267737861 a2276 loss_cnaBRCA28_(GPS2) 176 IPA-3 PAK1, PAK2, PAK3 4 43 3.46573590279973 NA 5.44280178110273 4.40884295408747 1.03395882701526 1.0311796595722 1.51988514898525 0.692866164829272 1.00269513407995 0.680287472843317 0.191710776695186 NA NA NA 0.136018134353155 96.5848267737861 a2277 POLR2B_mut 1004 Vinblastine Microtubules 3 42 -2.30258509299405 NA -2.51750193652859 -3.52256452844469 1.00506259191609 1.81671613391631 1.23505777793885 0.792609978856275 0.553230399154034 0.813777792317871 0.191745323328825 NA NA NA 0.439893630424279 96.5848267737861 a2278 loss_cnaBRCA57 329 QL-XI-92 DDR1 5 43 2.32630161961136 NA 4.77829562345827 4.19229317665014 0.586002446808132 0.879685880839897 0.941351621572289 0.625970240143278 0.666149655884706 0.622511751591146 0.191779358374546 NA NA NA 0.219214816143006 96.5848267737861 a2279 loss_cnaBRCA36_(FAT1,IRF2) 1058 GDC0941 PI3K (class 1) 9 34 1.38629436111989 0.693147180559945 1.88462234875646 1.20342674563664 0.681195603119823 1.76560230174115 1.25442548197685 0.497500621750394 0.385814859013302 0.543033932989249 0.191802525940452 NA NA NA 0.30193004066498 96.5848267737861 a2280 ARID1A_mut 346 THZ-2-102-1 CDK7 5 43 0.916290731874155 2.99573227355399 0.0754699222019741 -1.49918409924633 1.5746540214483 2.72138155041856 2.49594854014264 0.625768266531115 0.578623023738115 0.630884009074288 0.191920104539283 NA NA NA 0.273710306829841 96.5848267737861 a2281 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 6 41 2.32630161961136 NA 2.18227836494564 1.30493499477976 0.877343370165882 0.686839225035394 1.58878927324908 0.578982148500569 1.27736352000087 0.552208769871484 0.191992703506562 NA NA NA 0.0335585293756851 96.5848267737861 a2282 loss_cnaBRCA29_(MAP2K4) 1009 ATRA Retinoic acid and retinoid X receptor agonist 6 39 2.30258509299405 NA 3.53005983855203 4.19457256897563 -0.664512730423596 0.960314476758342 1.16562119205048 0.581048815838731 0.691974084017497 0.570093212919913 0.192170905361566 NA NA NA 0.167083807586597 96.5848267737861 a2283 loss_cnaBRCA23 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 43 1.38629436111989 NA 3.94113086660707 2.78308447959892 1.15804638700815 0.560869956052932 1.49360174610255 0.790932828609484 2.06473242952394 0.775338131486517 0.192172160759369 NA NA NA 0.038119555643436 96.5848267737861 a2284 gain_cnaBRCA47_(EGFR) 291 KIN001-266 MAP3K8 (COT) 7 42 2.99573227355399 NA 3.23827536989785 3.86869424880576 -0.630418878907906 1.01300411284436 1.18800435822314 0.540146431136135 0.622326080333261 0.530653675253182 0.192208764733205 NA NA NA 0.171693355677437 96.5848267737861 a2285 gain_cnaBRCA31 1025 SB 216763 GSK3A, GSK3B 12 27 2.30258509299405 NA 5.13668251098251 4.77915192091634 0.357530590066167 1.02578232715497 0.641450609404196 0.460818632070602 0.348544306722251 0.557378206247642 0.192240447481734 NA NA NA 0.282673967063013 96.5848267737861 a2286 gain_cnaBRCA62 1192 GSK269962A ROCK1, ROCK2 7 39 1.6094379124341 NA 3.33468993416038 2.54827122600014 0.786418708160237 1.56335175893756 1.42743155041772 0.543588015451037 0.503033756583792 0.550932693010815 0.192255754279539 NA NA NA 0.250086875814209 96.5848267737861 a2287 gain_cnaBRCA12_(TERT) 254 AC220 FLT3 9 39 0.0237165266173161 NA 2.57104999383259 2.14361849028662 0.427431503545973 0.518800427554477 0.931101175114179 0.489337545804424 0.823884254607886 0.459060212756748 0.192292506252904 NA NA NA 0.0747007747248416 96.5848267737861 a2288 loss_cnaBRCA7_(FAS,PTEN) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 4 43 2.99573227355399 NA 2.95418469920457 3.93077656084799 -0.976591861643424 1.07665911985002 1.43236833624819 0.691908716057034 0.907057622638692 0.681802185184726 0.192313792514915 NA NA NA 0.166977559458923 96.5848267737861 a2289 CDH1_mut 1003 Camptothecin TOP1 4 41 -2.30258509299405 NA -1.53713736304376 -2.6260759885158 1.08893862547205 1.8958596652408 1.54241742448421 0.693741345355048 0.574377231309331 0.705994763924682 0.19237268467533 NA NA NA 0.33803185449384 96.5848267737861 a2290 loss_cnaBRCA17 272 AR-42 HDAC 11 38 1.63315443905142 NA -0.389208709930077 0.295730479061644 -0.68493918899172 1.05902214385592 1.61455760263076 0.452543323252566 0.646765691317696 0.424227161592551 0.192648090675309 NA NA NA 0.109744687917162 96.5848267737861 a2291 POLR2B_mut 1053 MK-2206 AKT1, AKT2 3 39 1.38629436111989 0.693147180559945 2.59087612637982 1.30180235488063 1.28907377149919 1.40727361217425 1.63447460690548 0.793828325575118 0.916007917968107 0.788677759845882 0.192711787698871 NA NA NA 0.248155275713685 96.5848267737861 a2292 gain_cnaBRCA10_(MDM2,NUP107) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 43 1.38629436111989 NA 1.77793301098467 2.93400526022374 -1.15607224923907 0.874228503995606 1.48651838361705 0.789530898480662 1.32239139304577 0.777704643265882 0.19294615869345 NA NA NA 0.131538816581635 96.5848267737861 a2293 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 305 TPCA-1 IKK 6 43 2.99573227355399 NA 3.48836059503341 4.27460065923416 -0.786240064200747 1.65316733929065 1.32782500798863 0.57552624870453 0.475596175604406 0.592126266240256 0.193023752540919 NA NA NA 0.307625740728228 96.5848267737861 a2294 NF1_mut 201 Epothilone B Microtubules 5 43 -3.44201937618241 NA -3.2379957447805 -4.35177678291174 1.11378103813124 1.30140587671631 1.82406887732976 0.624069540927621 0.855829113774647 0.610602511765724 0.193106974962413 NA NA NA 0.134932031628286 96.5848267737861 a2295 loss_cnaBRCA29_(MAP2K4) 295 NVP-BHG712 EPHB4 7 42 2.32630161961136 NA 3.32511412833234 3.98030727297011 -0.655193144637773 1.91808895013026 1.07516532610095 0.538915783101402 0.341586423608394 0.609388276139639 0.193205391130118 NA NA NA 0.40907241076762 96.5848267737861 a2296 gain_cnaBRCA14_(RAD21) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 20 25 0.693147180559945 NA 0.938142297370465 0.375510222343898 0.562632075026567 1.36588071981698 1.4593902941356 0.396545873352734 0.411918893695165 0.385525432975293 0.193217546300422 NA NA NA 0.19012960239798 96.5848267737861 a2297 gain_cnaBRCA58_(CCND1) 222 BX-912 PDPK1 (PDK1) 10 39 2.32630161961136 NA 4.44058760623675 3.74100979875008 0.699577807486666 1.18812526807499 1.55947492482536 0.467782161025645 0.588808121739663 0.448598304692207 0.193324829892305 NA NA NA 0.138489942053962 96.5848267737861 a2298 gain_cnaBRCA58_(CCND1) 300 CX-5461 RNA Pol I 10 39 2.32630161961136 NA 4.54142500542874 3.75106793111987 0.79035707430887 1.74792408012507 1.67557067742554 0.467759507891906 0.452168994806868 0.471694262114462 0.193346011465874 NA NA NA 0.219847985844212 96.5848267737861 a2299 gain_cnaBRCA31 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 10 16 2.30258509299405 NA 3.09154144103832 2.4415433317577 0.649998109280624 1.34128641217674 1.11616575690285 0.539183682787062 0.484607987809077 0.582349086827613 0.193581471215718 NA NA NA 0.218046773240317 96.5848267737861 a2300 gain_cnaBRCA62 1052 RO-3306 CDK1 7 36 1.6094379124341 NA 4.06793788034023 3.42023303737982 0.647704842960402 0.797238812462042 1.24096687124021 0.545921732443174 0.812435161002953 0.521935643868633 0.193632420484537 NA NA NA 0.10069747602701 96.5848267737861 a2301 gain_cnaBRCA31 1050 ZM-447439 AURKB 12 27 1.38629436111989 0.693147180559945 3.30084323042881 2.7044044598392 0.596438770589609 1.26691359510327 1.31243618376632 0.459127831402245 0.470780937938385 0.45445163579535 0.193839523494711 NA NA NA 0.193378642060661 96.5848267737861 a2302 PIK3CA_mut 304 SB52334 ALK5 17 32 2.99573227355399 NA 3.97643688281093 4.47478964485715 -0.498352762046218 1.34529689255371 1.21324992401137 0.395594372813888 0.370440729332407 0.410758535552605 0.193855199358724 NA NA NA 0.211657707703023 96.5848267737861 a2303 gain_cnaBRCA19 303 PIK-93 PI4K, PI3K 4 45 2.99573227355399 NA 1.90346092652026 2.87046642394735 -0.967005497427095 0.852784755262312 1.43676026951371 0.687405394773397 1.13393853661191 0.673045822567455 0.194057195354786 NA NA NA 0.102352549350875 96.5848267737861 a2304 loss_cnaBRCA33 1008 Methotrexate Dihydrofolate reductase (DHFR) 5 40 -1.6094379124341 NA 0.0837248307026487 0.757515729916764 -0.673790899214115 1.08026680592617 1.07652086911138 0.6256938864725 0.623726375297108 0.625896736930239 0.194124448258685 NA NA NA 0.244953209607842 96.5848267737861 a2305 ASH1L_mut 1378 Bleomycin (50 uM) DNA damage 3 45 3.91202300542815 NA 2.43885912961315 3.90430817874114 -1.46544904912799 3.51376814313276 1.75409794115055 0.785575526458789 0.417059119848884 0.835443115660222 0.194212315615334 NA NA NA 0.545976776736548 96.5848267737861 a2306 TP53_mut 60 BI-2536 PLK1, PLK2, PLK3 9 3 -1.36257783450257 NA -1.15182177493012 -2.53595844176475 1.38413666683463 1.65377971098555 0.437211776212863 0.927672891738294 0.836953469461647 3.16582659054624 0.194247877114762 NA NA NA 0.0456704061423164 96.5848267737861 a2307 gain_cnaBRCA31 1192 GSK269962A ROCK1, ROCK2 15 31 1.6094379124341 NA 3.0721697593423 2.47235035364496 0.59981940569734 1.36641162491282 1.48308289229732 0.414531640165883 0.438974167638256 0.404440917505433 0.194334766190472 NA NA NA 0.18496396323838 96.5848267737861 a2308 PTEN_mut 1378 Bleomycin (50 uM) DNA damage 8 40 3.91202300542815 NA 3.02030301803376 3.97120053219802 -0.950897514164258 2.66222438468386 1.68305889499281 0.509723629443687 0.357181580799463 0.564981722857846 0.194661180843428 NA NA NA 0.358924231867112 96.5848267737861 a2309 loss_cnaBRCA20 1004 Vinblastine Microtubules 3 42 -2.30258509299405 NA -2.52375817446585 -3.52211765430631 0.998359479840459 1.01173982761955 1.27958985453635 0.787109785259085 0.98677491246878 0.780218345981033 0.194785529694592 NA NA NA 0.222339929176392 96.5848267737861 a2310 MLL3_mut 1019 Bosutinib SRC, ABL, TEC 3 42 0.693147180559945 NA 3.34073350753499 2.61416032515105 0.726573182383937 1.22602901380683 0.905887107658253 0.786979942871066 0.592623155081724 0.802057095460992 0.194857739251449 NA NA NA 0.413217331529048 96.5848267737861 a2311 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 7 40 0.940007258491471 NA 2.4573365216319 1.78914008330623 0.668196438325673 1.02302063567293 1.26944771862708 0.539118146823202 0.653160273630395 0.526367827930979 0.194880999293513 NA NA NA 0.157481032058069 96.5848267737861 a2312 loss_cnaBRCA42 272 AR-42 HDAC 3 46 1.63315443905142 NA -0.97152797458561 0.214587963453662 -1.18611593803927 0.530409742779221 1.54304121818882 0.783528713180572 2.23622577485909 0.768687138138477 0.194919617531713 NA NA NA 0.0284482750931938 96.5848267737861 a2313 loss_cnaBRCA57 1013 Nilotinib ABL 5 35 0.693147180559945 NA 3.72452743969351 3.12839023136443 0.59613720832908 0.374218651512333 0.990834392959868 0.630788383058535 1.59301842898505 0.601651711491636 0.194934076841311 NA NA NA 0.0242727031566335 96.5848267737861 a2314 gain_cnaBRCA14_(RAD21) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 20 26 2.30258509299405 NA 1.63084962040004 1.24573283442772 0.385116785972324 0.871954001087034 1.06105879090422 0.391430983761063 0.441670988942321 0.362955181441108 0.194967086862435 NA NA NA 0.183789486808284 96.5848267737861 a2315 gain_cnaBRCA19 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 3 42 -0.669430653942629 NA -5.25064429509149 -3.36015914701939 -1.8904851480721 2.39547913954308 2.40317953314263 0.786777051750638 0.789188733420863 0.786659973589203 0.194970614266571 NA NA NA 0.302888300952096 96.5848267737861 a2316 loss_cnaBRCA17 158 PF-562271 FAK 9 36 0.940007258491471 NA 1.83322584739683 2.45825629509295 -0.625030447696125 0.967161310044894 1.3341814694555 0.490631648425484 0.646252534302796 0.468474837947802 0.194979578734865 NA NA NA 0.129399681021705 96.5848267737861 a2317 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 275 I-BET BRD2, BRD3, BRD4 6 43 2.99573227355399 NA 3.3630579089804 4.133250336125 -0.770192427144593 0.513189286887652 1.41163082219276 0.572680563213106 1.50079599637707 0.545604711257448 0.195194481295667 NA NA NA 0.0191649223934694 96.5848267737861 a2318 MLL3_mut 1091 BMS-536924 IGF1R 3 44 1.38629436111989 NA 3.81817777453915 2.96910615860279 0.849071615936357 1.0694999658189 1.08296586614768 0.784455296455058 0.79389587945076 0.784024356147689 0.195292535833204 NA NA NA 0.300698239941909 96.5848267737861 a2319 gain_cnaBRCA16 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 14 29 1.6094379124341 NA 3.2753395250528 2.67129247300138 0.604047052051416 1.41222943058246 1.40879803323742 0.428436518053487 0.427725863071895 0.428767671305813 0.19532418210973 NA NA NA 0.199995973582185 96.5848267737861 a2320 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1010 Gefitinib EGFR 7 38 -0.693147180559945 NA 0.929475536582897 1.4865545501174 -0.557079013534498 0.869450330444234 1.05329789434455 0.541054410139392 0.640725518213175 0.52889027551048 0.195328786623778 NA NA NA 0.164837912197874 96.5848267737861 a2321 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 158 PF-562271 FAK 5 40 0.940007258491471 NA 1.62667036656441 2.42157268542739 -0.794902318862986 0.988987877338521 1.29967146691893 0.623956420631136 0.803753349335443 0.611617888901897 0.195341398875465 NA NA NA 0.155205513762467 96.5848267737861 a2322 gain_cnaBRCA64_(SDHC) 1243 piperlongumine Increases ROS levels 9 38 2.30258509299405 NA 2.04274241123909 1.6314983003878 0.411244110851288 1.05474241003762 0.79125262821103 0.487182204279089 0.389900042832846 0.519738066186376 0.195444681015311 NA NA NA 0.297044384499667 96.5848267737861 a2323 gain_cnaBRCA12_(TERT) 163 JQ1 BRD4 9 38 0.940007258491471 NA 0.88382159381127 0.18141296450423 0.70240862930704 2.02361531815488 1.28220823019024 0.487058005164437 0.347105807613422 0.547811668002492 0.195556499720491 NA NA NA 0.34417752857109 96.5848267737861 a2324 gain_cnaBRCA27_(CLTC,PPM1D) 211 TL-2-105 CRAF 9 40 2.32630161961136 1.63315443905142 3.48180598001009 4.00334698173434 -0.521541001724242 1.10792897164038 1.07033414045922 0.484331751823985 0.470735051681206 0.48726933208024 0.195627078268919 NA NA NA 0.224237420970557 96.5848267737861 a2325 gain_cnaBRCA8_(CHD4,WNK1) 1058 GDC0941 PI3K (class 1) 3 40 1.38629436111989 0.693147180559945 2.349273249489 1.27075726854967 1.07851598093932 1.66217790877478 1.35303465294322 0.787390523401903 0.648857126090862 0.797108912615991 0.195695818526412 NA NA NA 0.377980691251343 96.5848267737861 a2326 gain_cnaBRCA13_(FGFR1,WHSC1L1) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 10 38 2.07944154167984 NA 3.63850799489819 3.10267067605786 0.53583731884033 1.30351490044966 1.10760306264089 0.466527193033913 0.411071111389282 0.483781001438111 0.195813376092225 NA NA NA 0.255308647727642 96.5848267737861 a2327 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 254 AC220 FLT3 14 34 0.0237165266173161 NA 1.96580921489679 2.32997770756225 -0.364168492665457 0.725705528109781 0.925591032069627 0.41678825431175 0.501813033743857 0.393444275114868 0.195863726949792 NA NA NA 0.156332227481168 96.5848267737861 a2328 loss_cnaBRCA36_(FAT1,IRF2) 200 LAQ824 HDAC 9 39 0.0237165266173161 NA -3.23481314549256 -2.5574645478217 -0.67734859767086 1.25167397006598 1.42402412084694 0.485352761335113 0.541154177421419 0.475658092973879 0.19587169709787 NA NA NA 0.17741284576028 96.5848267737861 a2329 loss_cnaBRCA28_(GPS2) 299 OSI-027 MTORC1/2 4 44 2.99573227355399 NA 0.0354213645016664 1.38111030900579 -1.34568894450412 1.11892460790672 2.00925897845536 0.68533877051119 1.20266274867404 0.66974390008133 0.1959216628355 NA NA NA 0.0881872580203282 96.5848267737861 a2330 loss_cnaBRCA18 1033 Vismodegib SMO 14 31 2.30258509299405 NA 4.53441867514681 4.86154819947191 -0.327129524325104 0.869092540635094 0.727995015462037 0.422991137728253 0.376403557768488 0.449356818902784 0.19593996018993 NA NA NA 0.232921957466138 96.5848267737861 a2331 NF1_mut 1052 RO-3306 CDK1 4 39 1.6094379124341 NA 4.26815193331647 3.44952171217409 0.818630221142384 0.625292944440504 1.22009330515681 0.689823853573982 1.30919471972433 0.670957063433087 0.196180286239896 NA NA NA 0.0702364433165116 96.5848267737861 a2332 gain_cnaBRCA48 1259 BMN-673 PARP1 5 41 2.30258509299405 NA 2.45256001270731 3.40955975120261 -0.956999738495293 1.82469368602669 1.50798855280518 0.621640494118572 0.524471447357928 0.634620028590449 0.19621957153087 NA NA NA 0.314158116731995 96.5848267737861 a2333 gain_cnaBRCA63 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 7 42 3.68887945411394 NA 2.91701129996385 3.54986650298805 -0.632855203024203 0.759738841931941 1.23242918809955 0.535115001772459 0.832990454213074 0.513502284054217 0.196308146912634 NA NA NA 0.0908550788053706 96.5848267737861 a2334 gain_cnaBRCA27_(CLTC,PPM1D) 178 BAY 61-3606 SYK 9 39 2.07944154167984 NA 2.46965689002735 3.24023649819105 -0.770579608163698 2.15555526146668 1.44202500069095 0.484855361093119 0.357485434003387 0.534373265230821 0.196321986930533 NA NA NA 0.331991392817352 96.5848267737861 a2335 loss_cnaBRCA18 153 Midostaurin KIT 15 32 -0.669430653942629 NA 0.209949843055625 0.800731355875487 -0.590781512819862 1.08707073704651 1.57309889980673 0.410383781953549 0.543461885861238 0.375552683237172 0.196347693245006 NA NA NA 0.143049868540699 96.5848267737861 a2336 loss_cnaBRCA60 190 Bleomycin DNA damage 3 45 4.15888308335967 NA 0.0896050218710049 2.21098543195998 -2.12138041008897 1.99815532015767 2.74223038104619 0.781607679158283 1.06166942513837 0.77359671337302 0.19643332728216 NA NA NA 0.198111692468165 96.5848267737861 a2337 ASH1L_mut 1494 SN-38 TOP1 3 45 -2.99573227355399 NA -4.52411432034034 -3.22243345589581 -1.30168086444454 1.35587226242155 1.6781867309807 0.781569393517349 0.960032077151405 0.775647215184369 0.196454850982577 NA NA NA 0.232025587952621 96.5848267737861 a2338 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 269 NSC-207895 MDM4 15 34 2.99573227355399 NA 4.93520720805453 4.4577961604246 0.477411047629932 1.10953809591196 1.20236860607789 0.406140035947294 0.430279094867431 0.397058809766534 0.196469976203487 NA NA NA 0.186670346217853 96.5848267737861 a2339 MLL3_mut 133 Doxorubicin DNA intercalating 3 45 0.0237165266173161 NA -2.36060839624492 -0.941980756019878 -1.41862764022505 2.0851605334309 1.80225841120897 0.78140834425414 0.680344566991614 0.78713886499407 0.196545410369209 NA NA NA 0.359562559207481 96.5848267737861 a2340 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1059 AZD8055 MTORC1/2 8 35 0.693147180559945 NA -0.286404601761862 0.225707381743252 -0.512111983505115 1.06076104275291 0.981629563440077 0.514382901212932 0.482777895176154 0.521695762412087 0.196619351166502 NA NA NA 0.240394557832929 96.5848267737861 a2341 loss_cnaBRCA33 29 AZ628 BRAF 5 9 1.38629436111989 NA 1.52162702345669 3.021898986359 -1.50027196290231 2.91314817123714 1.24994503446297 0.762593086191434 0.515000224744895 1.20027034912531 0.196624189411721 NA NA NA 0.324308990219536 96.5848267737861 a2342 BRCA1_mut 341 EX-527 SIRT1 4 45 2.99573227355399 NA 6.04823341467995 5.60562166760217 0.442611747077786 0.113531358909335 0.668764535453105 0.683354447545327 3.89858582976401 0.661834956271873 0.19665079231957 NA NA NA 0.000554990873636098 96.5848267737861 a2343 gain_cnaBRCA8_(CHD4,WNK1) 200 LAQ824 HDAC 3 45 0.0237165266173161 NA -3.70664199603947 -2.61632243747469 -1.09031955856478 0.926104128335755 1.41331135154537 0.781216160515849 1.17731853816927 0.771464516557218 0.196653518262434 NA NA NA 0.165456184092894 96.5848267737861 a2344 loss_cnaBRCA33 224 AS605240 PI3Kgamma 6 43 2.99573227355399 2.32630161961136 2.4868974845482 3.37956269324605 -0.892665208697845 3.21585043376008 1.22745035255194 0.570706674242227 0.277582937106348 0.727251580352672 0.196711010640895 NA NA NA 0.529592699212726 96.5848267737861 a2345 NF1_mut 1053 MK-2206 AKT1, AKT2 4 38 1.38629436111989 0.693147180559945 2.40808963790342 1.28712004389132 1.1209695940121 1.03722991116208 1.66304857807024 0.690041204228993 1.08073396452307 0.6740450091439 0.196759404215952 NA NA NA 0.115507526299334 96.5848267737861 a2346 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 164 JQ12 HDAC 6 41 1.63315443905142 NA 0.766824761693463 1.69657464588526 -0.929749884191801 2.11012028532959 1.55196978430953 0.572685796007443 0.440614637305655 0.599077310390707 0.196779458344859 NA NA NA 0.340065958709245 96.5848267737861 a2347 PIK3CA_mut 288 KIN001-055 JAK3, MNK1 17 32 2.32630161961136 NA 4.55617093461273 4.22363864385061 0.332532290762129 0.703019756027655 0.911487624480496 0.392922647611794 0.473005613158114 0.364823703395486 0.196828776607319 NA NA NA 0.163973008379434 96.5848267737861 a2348 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1038 NU-7441 PRKDC (DNAPK) 8 35 0.693147180559945 NA 3.28344322117796 2.80358999727175 0.479853223906204 0.826015780715962 0.954070566728655 0.514063106421771 0.580925007861573 0.502953597606033 0.196892136244495 NA NA NA 0.176545304347939 96.5848267737861 a2349 loss_cnaBRCA57 306 TG101348 JAK2 5 43 2.32630161961136 NA 3.92815628687628 3.14311365779443 0.785042629081849 1.14952220720117 1.28029565190562 0.618407257693886 0.682929502504572 0.613172924483007 0.19710334236017 NA NA NA 0.210326096422075 96.5848267737861 a2350 loss_cnaBRCA29_(MAP2K4) 274 PXD101, Belinostat HDAC 7 41 2.99573227355399 NA -0.00497794354768432 0.787000151492571 -0.791978095040256 0.782573164804769 1.55767138654367 0.535200732160317 1.01201795647802 0.508437210750582 0.197139966877849 NA NA NA 0.0554452337074994 96.5848267737861 a2351 gain_cnaBRCA58_(CCND1) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 8 35 -1.38629436111989 0.693147180559945 -1.82722413015681 -2.31040532619935 0.483181196042541 0.954321288184168 0.93829334542766 0.513449479937476 0.506308726447791 0.514957500654888 0.197416364337636 NA NA NA 0.223174345902486 96.5848267737861 a2352 NF1_mut 1149 TW 37 BCL2, BCL2L1 5 38 1.6094379124341 NA 0.53629091116463 -0.231683604606938 0.767974515771568 2.34122222772126 1.0438661782284 0.62329686615706 0.328022904736834 0.735702077324644 0.197421409612106 NA NA NA 0.507203505106289 96.5848267737861 a2353 loss_cnaBRCA28_(GPS2) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 3 40 0.693147180559945 NA 3.59734078671843 2.85674953652586 0.74059125019257 0.142790166187522 0.967735450197113 0.784222407240732 5.18657040583575 0.765282753713034 0.19746374731217 NA NA NA 0.000260873123519239 96.5848267737861 a2354 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 111 Salubrinal GADD34-PP1C 3 10 2.77258872223978 NA 3.97368632934701 3.01590094100863 0.957785388338387 1.31052548516087 0.99716397623593 0.902681336043836 0.730840719378165 0.9605094158674 0.197615399702755 NA NA NA 0.334272158125604 96.5848267737861 a2355 gain_cnaBRCA58_(CCND1) 1009 ATRA Retinoic acid and retinoid X receptor agonist 9 36 2.30258509299405 NA 4.55214285557553 3.99442787558839 0.557714979987148 1.01570836408034 1.1716160599566 0.487419533044393 0.549089679390525 0.476021965769065 0.197861915457773 NA NA NA 0.175738259142878 96.5848267737861 a2356 gain_cnaBRCA30_(CRNKL1,FOXA2) 1149 TW 37 BCL2, BCL2L1 4 39 1.6094379124341 NA 0.625520369254993 -0.221143689647705 0.846664058902698 1.28654165599441 1.22777514955609 0.687132405210734 0.658093000687402 0.689592112374007 0.197895780707005 NA NA NA 0.283878539354595 96.5848267737861 a2357 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 273 CUDC-101 HDAC, EGFR 6 43 1.63315443905142 NA -0.80190680690573 0.0815270648370644 -0.883433871742794 0.883321907788621 1.61366458361256 0.569080709314134 1.00012675328573 0.547470571464749 0.197966907557153 NA NA NA 0.0692944122459371 96.5848267737861 a2358 gain_cnaBRCA15 1239 YK 4-279 RNA helicase A 20 22 2.30258509299405 NA 2.2844498848082 1.76728287591407 0.517167008894131 1.4808851115696 1.06328998964524 0.404426643297456 0.349228312752759 0.486383784226805 0.198003001976718 NA NA NA 0.206144403028597 96.5848267737861 a2359 NF1_mut 1091 BMS-536924 IGF1R 5 42 1.38629436111989 NA 3.62127677108858 2.95211477254042 0.669161998548165 0.861824583404709 1.10179179322676 0.618096485010426 0.776448028326815 0.607339792020438 0.198013155593194 NA NA NA 0.165974119031313 96.5848267737861 a2360 loss_cnaBRCA18 52 GNF-2 ABL [T315I] 5 7 0.246860077931526 NA 2.7395862786273 2.30630316655605 0.433283112071247 0.265992902042616 0.65799633756306 0.807268345193474 1.62892734634636 0.658488637909361 0.198052615496627 NA NA NA 0.152877528318004 96.5848267737861 a2361 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 6 37 1.6094379124341 NA 3.56666585785593 2.75465513299037 0.812010724865562 1.33774074173866 1.42001771015445 0.575795731357672 0.607001565796816 0.571831406790864 0.198055463367214 NA NA NA 0.214074053902283 96.5848267737861 a2362 loss_cnaBRCA18 328 SNX-2112 HSP90 16 32 0.940007258491471 NA -0.120614982452925 0.686167426365551 -0.806782408818476 1.87757856451943 2.08297597522683 0.399734313175729 0.429693022739089 0.387321994307025 0.198205604304207 NA NA NA 0.185444329378891 96.5848267737861 a2363 gain_cnaBRCA16 1054 PD-0332991 CDK4, CDK6 14 28 1.38629436111989 0.693147180559945 3.29618113892529 2.67626653801094 0.619914600914354 1.35727184442447 1.48925854207494 0.428211452231489 0.456735769964504 0.416257206791405 0.198270874264057 NA NA NA 0.187609140247129 96.5848267737861 a2364 loss_cnaBRCA38 1218 JQ1 BRD2, BRD3, BRD4 3 43 0 NA 1.95181746359674 2.49329566794294 -0.541478204346203 1.07546713113121 0.670771452775895 0.779887303579344 0.503481871897524 0.807246942465082 0.198334648282056 NA NA NA 0.476110850465797 96.5848267737861 a2365 PTEN_mut 255 CP724714 ERBB2 9 39 2.32630161961136 NA 4.45037655712185 3.65364933016522 0.79672722695663 0.622233492786609 1.79387120640037 0.482584913820926 1.28043127892163 0.444138477787021 0.19838734387075 NA NA NA 0.0303483871871839 96.5848267737861 a2366 loss_cnaBRCA33 202 GSK-1904529A IGF1R 6 42 0.0237165266173161 NA 1.77906030593919 2.24833358475457 -0.469273278815385 0.878514723051842 0.817174729866608 0.569462642970681 0.534166663917928 0.57426308188946 0.198450052213616 NA NA NA 0.26111218607635 96.5848267737861 a2367 gain_cnaBRCA63 282 EKB-569 EGFR 6 41 0.916290731874155 2.99573227355399 2.61957641549898 1.42565150619171 1.19392490930727 1.91482024158917 2.11423699232937 0.570432208672213 0.623518011443408 0.564707227070063 0.198514511073299 NA NA NA 0.202759623908166 96.5848267737861 a2368 gain_cnaBRCA27_(CLTC,PPM1D) 306 TG101348 JAK2 9 39 2.32630161961136 NA 3.72254532994749 3.11004514743627 0.612500182511227 1.13094068911775 1.29691055163201 0.482433381445815 0.541584707672901 0.472276350701647 0.198525770319189 NA NA NA 0.177680644083444 96.5848267737861 a2369 loss_cnaBRCA7_(FAS,PTEN) 1006 Cytarabine DNA synthesis 4 41 0.693147180559945 NA 2.15020876137215 1.11666249561562 1.03354626575653 1.85263029686856 1.48237862704511 0.683943784954355 0.557880472700626 0.697221510685664 0.198604761079819 NA NA NA 0.35004974448784 96.5848267737861 a2370 ASH1L_mut 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 44 2.99573227355399 NA 4.87691756235469 3.77748586877768 1.09943169357701 1.25362793644042 1.41914159593494 0.778525495851434 0.876999994670481 0.774715995025642 0.198627941413069 NA NA NA 0.263991847140302 96.5848267737861 a2371 PTEN_mut 281 CH5424802 ALK 9 39 1.63315443905142 NA 3.16244825187165 3.670499173934 -0.508050922062357 1.18655487018332 1.02361616736254 0.482129380978116 0.428173137904584 0.496329521026819 0.198803697937497 NA NA NA 0.260547383308726 96.5848267737861 a2372 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 224 AS605240 PI3Kgamma 7 42 2.99573227355399 2.32630161961136 2.55719247043975 3.38910079580455 -0.831908325364792 1.33132059280118 1.59569438199863 0.531763076887768 0.624874526739203 0.521345650363709 0.199075617150485 NA NA NA 0.171188852725679 96.5848267737861 a2373 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1149 TW 37 BCL2, BCL2L1 17 26 1.6094379124341 NA 0.16088626350566 -0.340676496109105 0.501562759614766 1.56002936986803 0.965892000165346 0.407008109147097 0.321508536507357 0.519274162669228 0.199200831160209 NA NA NA 0.247452877192325 96.5848267737861 a2374 gain_cnaBRCA16 110 Roscovitine CDKs 3 10 2.77258872223978 NA 3.4043993984524 4.28271133700335 -0.878311938550946 0.313213104380572 1.06967453472798 0.89923628954383 2.80419920580254 0.821102036213567 0.199204317970826 NA NA NA 0.0430322352453937 96.5848267737861 a2375 gain_cnaBRCA8_(CHD4,WNK1) 211 TL-2-105 CRAF 4 45 2.32630161961136 1.63315443905142 3.23566469027929 3.9672772072966 -0.731612517017309 1.19577797006374 1.06857534897472 0.679215413130712 0.611829733724158 0.684661608298636 0.199327763065734 NA NA NA 0.312278553138257 96.5848267737861 a2376 TP53_mut 1067 CCT007093 PPM1D 36 10 1.88706964903238 NA 4.18433968492182 3.73030376425023 0.454035920671599 0.933371686081531 1.12160949751271 0.465756012478938 0.486447068667496 0.404807485741226 0.199366584522559 NA NA NA 0.26263422060031 96.5848267737861 a2377 gain_cnaBRCA15 54 CGP-082996 CDK4 6 6 1.63315443905142 NA 2.42441231428721 3.19376319030902 -0.769350876021815 1.23778194557679 0.590828839727493 0.793275321218767 0.621556065485594 1.30215525087885 0.199455379851265 NA NA NA 0.210878888225079 96.5848267737861 a2378 loss_cnaBRCA18 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 15 32 2.32630161961136 NA 0.996305454194997 1.61410697383497 -0.617801519639974 0.646265717068365 1.77448197755821 0.407445774803331 0.955955891397873 0.348158802091698 0.199510758415753 NA NA NA 0.0891732326425152 96.5848267737861 a2379 PTEN_mut 158 PF-562271 FAK 8 37 0.940007258491471 NA 1.80089360715948 2.44835433493627 -0.647460727776794 1.15057374135119 1.29714654079203 0.508037420732201 0.562728580105121 0.499142315394419 0.199518669514475 NA NA NA 0.185766003127166 96.5848267737861 a2380 loss_cnaBRCA17 1052 RO-3306 CDK1 6 37 1.6094379124341 NA 4.11186312086906 3.4306155616984 0.681247559170656 0.786172445431458 1.23249644293681 0.573882502262775 0.866537059559219 0.552737951557384 0.199519990548875 NA NA NA 0.104271466522483 96.5848267737861 a2381 loss_cnaBRCA57 260 NG-25 MAP3K7 (TAK1) 5 44 2.32630161961136 NA 3.9097668995056 3.1286361893537 0.781130710151896 1.47658381015908 1.25133123042618 0.614069683976973 0.529012105359426 0.624239762549406 0.199546167592614 NA NA NA 0.310265178412789 96.5848267737861 a2382 ARID1A_mut 1038 NU-7441 PRKDC (DNAPK) 4 39 0.693147180559945 NA 2.31323189813517 2.9523145661896 -0.639082668054429 1.04791862745906 0.924062311161447 0.684475546847669 0.609859059003508 0.691601270103929 0.19960036503665 NA NA NA 0.31419257215599 96.5848267737861 a2383 loss_cnaBRCA17 279 BIX02189 MAP2K5 (MEK5) 11 38 2.99573227355399 NA 4.7196404254289 5.11643161849997 -0.396791193071071 0.964263062903974 0.869865957583769 0.445438112683209 0.411496829377759 0.456152111266936 0.19960056273125 NA NA NA 0.238389706020096 96.5848267737861 a2384 BRCA1_mut 1030 KU-55933 ATM 4 38 2.30258509299405 NA 4.78734246953234 4.16282113247058 0.624521337061759 0.426041828091931 0.939593542924321 0.685403500413805 1.4658685975946 0.664671805979047 0.199722708449156 NA NA NA 0.0500599312596866 96.5848267737861 a2385 loss_cnaBRCA18 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 16 33 3.68887945411394 NA 3.14384283877505 3.61248444863165 -0.468641609856602 1.19140250680582 1.17901220263591 0.396153232136856 0.393352882153187 0.397486649255081 0.199799281020178 NA NA NA 0.205154839790152 96.5848267737861 a2386 gain_cnaBRCA16 111 Salubrinal GADD34-PP1C 3 10 2.77258872223978 NA 2.50364094691664 3.45691455573774 -0.953273608821094 0.265201474906207 1.16729563861608 0.897708239131713 3.59452604537074 0.816651392573758 0.199912483306381 NA NA NA 0.0363262093336166 96.5848267737861 a2387 gain_cnaBRCA58_(CCND1) 221 TAK-715 p38a 10 39 2.99573227355399 2.32630161961136 4.84755412427454 4.38846004456769 0.459094079706848 1.10657695319103 0.968418149625664 0.460772120062921 0.414877680565241 0.474065959920627 0.199963782062879 NA NA NA 0.252139704095714 96.5848267737861 a2388 POLR2B_mut 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 3 44 2.77258872223978 NA 4.27456628186396 5.06110615571573 -0.786539873851772 2.1628613111722 0.926351179594368 0.775793049172863 0.363657100799262 0.849073106590292 0.200179306343773 NA NA NA 0.593872507855591 96.5848267737861 a2389 loss_cnaBRCA29_(MAP2K4) 1066 AZD6482 PI3Kbeta 7 36 1.6094379124341 NA 2.60726298289664 1.84272854313454 0.764534439762101 1.0532389793856 1.47553821794063 0.53780011845387 0.725888857824166 0.518139368039645 0.200208379768122 NA NA NA 0.130114344849288 96.5848267737861 a2390 gain_cnaBRCA14_(RAD21) 260 NG-25 MAP3K7 (TAK1) 21 28 2.32630161961136 NA 3.48091218980981 3.00391681582446 0.476995373985342 1.51141714197377 1.06063344190747 0.374957273089612 0.315594788982234 0.449726885027781 0.20031807134116 NA NA NA 0.224950921026667 96.5848267737861 a2391 gain_cnaBRCA62 290 KIN001-260 IKK 10 39 2.99573227355399 NA 5.42195489663023 4.94718100382731 0.474773892802925 1.05186942444761 1.02638344237821 0.460358908056458 0.451362005367018 0.462569711474335 0.200360419635729 NA NA NA 0.22185905531335 96.5848267737861 a2392 ARID1A_mut 1018 ABT-888 PARP1, PARP2 5 40 1.6094379124341 NA 4.04291300719021 4.4480965901259 -0.405183582935684 0.900147020188657 0.626728201497192 0.616736175124302 0.45013044963562 0.646506064299867 0.200460655636836 NA NA NA 0.377991077211186 96.5848267737861 a2393 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1268 XAV 939 TNKS1 (tankyrase-1) 6 41 1.6094379124341 NA 4.1217051975589 3.5940871962372 0.527618001321702 1.06881200574741 0.910344222812292 0.567766362985469 0.493649021983754 0.579580765275526 0.200581862428639 NA NA NA 0.293276016183073 96.5848267737861 a2394 gain_cnaBRCA14_(RAD21) 301 PHA-793887 CDK-pan 21 27 2.32630161961136 NA 2.57709946946405 3.19073580134414 -0.613636331880083 1.74911999660039 1.52209629638362 0.377690971303456 0.350825748417921 0.403152108929003 0.200724739057137 NA NA NA 0.209555632900208 96.5848267737861 a2395 gain_cnaBRCA19 294 MPS-1-IN-1 MPS1 4 45 2.99573227355399 NA 4.03493971958449 4.8206579681426 -0.785718248558115 1.01899267949405 1.16949565183549 0.677067583702619 0.771073496767649 0.671843668101676 0.200727684515752 NA NA NA 0.223053177586113 96.5848267737861 a2396 gain_cnaBRCA12_(TERT) 1219 PFI-1 BRD2, BRD3, BRD4 10 37 2.30258509299405 NA 3.53215186693482 3.07527273689702 0.456879130037798 1.37839906595714 0.862295010042278 0.462737701264316 0.331456354927626 0.52984086039811 0.200786945408992 NA NA NA 0.340348604151075 96.5848267737861 a2397 MLL3_mut 186 Bexarotene Retinioic acid X family agonist 3 44 2.07944154167984 NA 2.78630712540288 3.66018489428535 -0.873877768882468 2.51067756560165 1.01905275533334 0.774688154392407 0.348064514876507 0.857539282739699 0.200809207686288 NA NA NA 0.608523753876982 96.5848267737861 a2398 loss_cnaBRCA18 1166 QL-VIII-58 MTOR, ATR 7 19 2.30258509299405 NA -1.0519341861915 -1.69111392672643 0.639179740534925 1.28397512886696 1.0304680299341 0.581421857087444 0.497813178903993 0.620281000445788 0.20093201330648 NA NA NA 0.266660094914866 96.5848267737861 a2399 BRCA2_mut 1203 QL-XII-61 BTK 3 20 2.30258509299405 NA 3.17677588939708 4.38247631037058 -1.2057004209735 2.25815375118449 1.36674385571035 0.817404528480357 0.533931943447636 0.882169995450136 0.200969162492573 NA NA NA 0.454545678176228 96.5848267737861 a2400 loss_cnaBRCA57 302 PI-103 PI3Ka, PRKDC (DNAPK) 5 43 2.32630161961136 NA 2.13564003028215 1.01131608139574 1.12432394888642 1.4724630240994 1.86564688972976 0.612775782189971 0.763566847170298 0.602645631965906 0.20113968041262 NA NA NA 0.171442837747971 96.5848267737861 a2401 loss_cnaBRCA7_(FAS,PTEN) 177 GSK-650394 SGK3 4 43 2.77258872223978 NA 5.05550173712018 3.91759574836039 1.13790598875979 0.734511268228177 1.72575513767637 0.678136484844456 1.54920154118902 0.659367000518925 0.201147873267796 NA NA NA 0.0411264424370175 96.5848267737861 a2402 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 262 VX-11e ERK 6 43 1.63315443905142 NA 3.12378494858109 3.86793199056005 -0.744147041978958 1.16456091650605 1.33418573562499 0.564955023980837 0.638993659697569 0.55775370857969 0.201180747998886 NA NA NA 0.193501551820764 96.5848267737861 a2403 loss_cnaBRCA36_(FAT1,IRF2) 328 SNX-2112 HSP90 9 39 0.940007258491471 NA 1.20380691078898 0.235724505829488 0.968082404959494 1.91252613187558 2.04044423350328 0.47953835355977 0.506179962105988 0.474446882234743 0.201184435472964 NA NA NA 0.200387090581584 96.5848267737861 a2404 loss_cnaBRCA17 1053 MK-2206 AKT1, AKT2 6 36 1.38629436111989 0.693147180559945 2.19210974354754 1.26084060439441 0.931269139153135 2.00739082012671 1.56295389390019 0.573029135856931 0.463920194222246 0.595839162490744 0.20120961004535 NA NA NA 0.320065706841409 96.5848267737861 a2405 gain_cnaBRCA63 272 AR-42 HDAC 7 42 1.63315443905142 NA 0.828650645510983 0.0275216161079697 0.801129029403014 2.5111648654566 1.30647791270416 0.52893930831314 0.319026854995976 0.613197530255087 0.201429776975434 NA NA NA 0.438030241657219 96.5848267737861 a2406 NF1_mut 176 IPA-3 PAK1, PAK2, PAK3 5 42 3.46573590279973 NA 5.31526734394208 4.39940755786813 0.915859786073947 0.716859921686125 1.54857209356637 0.613223656013683 1.27759937244051 0.591422117109652 0.201507337999408 NA NA NA 0.0465653581451463 96.5848267737861 a2407 gain_cnaBRCA15 1022 AZD7762 CHEK1, CHEK2 21 24 0.693147180559945 NA 1.23643886104976 0.614523532115996 0.62191532893376 1.56888355863615 1.63539620180922 0.387533744649435 0.39640630148129 0.380284195503048 0.201569443013271 NA NA NA 0.200381076402787 96.5848267737861 a2408 loss_cnaBRCA7_(FAS,PTEN) 263 FR-180204 ERK 4 45 2.99573227355399 NA 5.80825315739257 5.31785215443436 0.490401002958205 0.426751694815841 0.741758422193451 0.675717775777381 1.14914834297221 0.661133043165242 0.201611249939888 NA NA NA 0.0991010608094957 96.5848267737861 a2409 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 37 Crizotinib MET, ALK 4 10 0.693147180559945 NA 3.0804275239131 2.4810384656021 0.599389058311 0.725990767273078 0.757735871764725 0.799264711267438 0.82561526307337 0.791026372969589 0.201617691592823 NA NA NA 0.218852091340744 96.5848267737861 a2410 gain_cnaBRCA14_(RAD21) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 20 26 0 NA 1.09713676273118 0.311736978260096 0.785399784471087 1.97215029811063 2.08568047284881 0.385485097006346 0.398245400070938 0.376567645281886 0.201706830173675 NA NA NA 0.198721574218142 96.5848267737861 a2411 NF1_mut 154 CHIR-99021 GSK3B 4 43 0.940007258491471 NA 2.72001382021864 3.32710411870161 -0.607090298482969 1.1750972048191 0.873149786698239 0.677216519765942 0.516629854954361 0.695287690304138 0.201748707888021 NA NA NA 0.381377465312745 96.5848267737861 a2412 gain_cnaBRCA15 38 AZD-0530 SRC, ABL1 6 8 0.693147180559945 NA 2.32493315169233 2.78264260868197 -0.457709456989633 0.537597902190607 0.684641117577097 0.729331280031718 0.851397401523622 0.66853924667779 0.201787368261294 NA NA NA 0.186712341565233 96.5848267737861 a2413 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 300 CX-5461 RNA Pol I 15 34 2.32630161961136 NA 4.38313279640386 3.70467374770307 0.678459048700789 1.13012046278559 1.87878116620943 0.401264200029845 0.600342238763189 0.361116590320962 0.201801120684993 NA NA NA 0.126035173044348 96.5848267737861 a2414 MLL3_mut 200 LAQ824 HDAC 3 45 0.0237165266173161 NA -3.69462111062325 -2.61712382983577 -1.07749728078748 0.518049240215369 1.42338041837238 0.771692401548759 2.07991286762535 0.756998808526246 0.202067363563884 NA NA NA 0.0370622162116095 96.5848267737861 a2415 gain_cnaBRCA12_(TERT) 164 JQ12 HDAC 9 38 1.63315443905142 NA 2.20800431500538 1.42864395306337 0.779360361942002 1.89779384265604 1.55875158454845 0.479840669539395 0.410666503613087 0.49999010083943 0.202137946279705 NA NA NA 0.277570499166871 96.5848267737861 a2416 loss_cnaBRCA17 6 PHA-665752 MET 4 10 0.693147180559945 NA 3.2803786118781 2.69799861449103 0.582379997387072 0.251498995923477 0.829908752005168 0.798174581693617 2.31563547698724 0.701739794862949 0.20219202814241 NA NA NA 0.0690117133276225 96.5848267737861 a2417 loss_cnaBRCA18 238 CAL-101 PI3Kdelta 16 33 2.99573227355399 2.32630161961136 4.47066429524017 4.83935206146444 -0.368687766224272 0.987502647831694 0.910833629354665 0.393903485523965 0.373353698882547 0.404780581592591 0.202320434036595 NA NA NA 0.219395225424645 96.5848267737861 a2418 loss_cnaBRCA24 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 3 43 0 NA 2.12514106276081 0.550522639560552 1.57461842320026 0.851219833168291 2.0772035831187 0.77280232876382 1.84983756468577 0.758047230419338 0.2023654608956 NA NA NA 0.0548584286220649 96.5848267737861 a2419 loss_cnaBRCA38 135 Gemcitabine DNA replication 4 43 0.0237165266173161 NA -1.96650456943 -0.117895279530483 -1.84860928989952 1.70479102956414 2.7935200168364 0.676042421779991 1.08436122541784 0.661749075989449 0.202517481458078 NA NA NA 0.11420782701259 96.5848267737861 a2420 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 6 41 0.940007258491471 NA 1.27709818214656 1.97815536319008 -0.701057181043517 1.84085719279491 1.14314850632355 0.565273459480784 0.380831921013453 0.613268684834455 0.20252975432446 NA NA NA 0.401603646331696 96.5848267737861 a2421 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 151 QS11 ARFGAP 15 33 2.32630161961136 NA 3.35489759563957 3.94479184599014 -0.589894250350572 1.30663508300664 1.5300415239164 0.402477533406669 0.451460593720776 0.385541334094409 0.202646067233474 NA NA NA 0.179633537758201 96.5848267737861 a2422 loss_cnaBRCA33 290 KIN001-260 IKK 6 43 2.99573227355399 NA 4.53440974739235 5.11518952630728 -0.580779778914939 0.750418881805529 1.06000764451436 0.563044530015638 0.773940785601725 0.547901500447217 0.202682232843591 NA NA NA 0.131678705916376 96.5848267737861 a2423 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 37 Crizotinib MET, ALK 3 11 0.693147180559945 NA 3.16949758774111 2.51123654440455 0.658261043336554 0.499327269083683 0.790892857607979 0.877436356351089 1.31829580336065 0.832301160649543 0.202827620512838 NA NA NA 0.13670302693887 96.5848267737861 a2424 BRCA1_mut 333 T0901317 LXR 4 44 2.32630161961136 NA 5.20329487358278 4.69290359988852 0.510391273694261 0.187251301868361 0.781064415746073 0.674515739382068 2.72570213719032 0.653456057406911 0.202948259244327 NA NA NA 0.00345585925742431 96.5848267737861 a2425 gain_cnaBRCA12_(TERT) 263 FR-180204 ERK 9 40 2.99573227355399 NA 5.07563830977428 5.4213903697787 -0.345752060004417 1.01034821569851 0.65229625110808 0.476358072334254 0.342210788946046 0.530053728527605 0.20295593119092 NA NA NA 0.350485081043582 96.5848267737861 a2426 gain_cnaBRCA58_(CCND1) 1017 Olaparib PARP1, PARP2 9 36 1.6094379124341 NA 4.4131569388065 3.98933338757061 0.423823551235881 0.536347896244421 0.940766067092367 0.48177264697339 0.790202691580503 0.450508969297539 0.203007097581166 NA NA NA 0.0884752326651192 96.5848267737861 a2427 loss_cnaBRCA18 1047 Nutlin-3a MDM2 12 31 2.07944154167984 1.38629436111989 4.52185967134431 4.08504194743183 0.436817723912478 0.750788403838575 1.06895407419146 0.439612247174191 0.581812028101591 0.408640309681106 0.203241028928656 NA NA NA 0.142361324875494 96.5848267737861 a2428 gain_cnaBRCA14_(RAD21) 1061 SB590885 BRAF 19 23 1.6094379124341 NA 4.24798615744787 3.81689366338749 0.431092494060376 0.875042171270535 1.21459372141463 0.400960709291885 0.492653392275303 0.354927319695251 0.203307742921859 NA NA NA 0.18989454056352 96.5848267737861 a2429 gain_cnaBRCA48 288 KIN001-055 JAK3, MNK1 5 44 2.32630161961136 NA 4.80176480169607 4.28642087461717 0.515343927078901 0.249100737102262 0.881989365738007 0.608615754660779 2.06881735105962 0.58429721161965 0.203498144760423 NA NA NA 0.00761663762116483 96.5848267737861 a2430 gain_cnaBRCA12_(TERT) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 10 37 2.99573227355399 NA 4.35910625124323 3.70943428110404 0.649671970139183 1.60966509434087 1.3590892958658 0.45985867114648 0.403606919491047 0.478020077205681 0.203552176453519 NA NA NA 0.264025614801006 96.5848267737861 a2431 BRCA1_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 4 39 2.30258509299405 NA 4.50516495416087 3.73756199710909 0.767602957051784 0.652506988001289 1.16130043837876 0.678182118678022 1.17639040066536 0.66098567750771 0.203682432854811 NA NA NA 0.0939649060269035 96.5848267737861 a2432 gain_cnaBRCA61_(NOTCH2) 133 Doxorubicin DNA intercalating 3 45 0.0237165266173161 NA 0.278652476478498 -1.11793148086811 1.3965839573466 0.894220091109468 1.84753535825949 0.768823838856555 1.56178995666922 0.755917309567643 0.203719812275636 NA NA NA 0.0894456770263942 96.5848267737861 a2433 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 304 SB52334 ALK5 7 42 2.99573227355399 NA 3.73330674517107 4.39665591492898 -0.663349169757913 1.47987003529756 1.22539574850181 0.526156450910602 0.448248260952546 0.541334642762501 0.20377027214655 NA NA NA 0.296188405972337 96.5848267737861 a2434 PTEN_mut 235 QL-XII-47 BTK, BMX 9 40 2.32630161961136 NA 2.28605567575513 1.57802946411036 0.708026211644775 1.2636191960824 1.5314431864738 0.475421041830573 0.560316125174315 0.462326136482432 0.20383056616781 NA NA NA 0.167329602158612 96.5848267737861 a2435 loss_cnaBRCA57 158 PF-562271 FAK 4 41 0.940007258491471 NA 3.118180890285 2.25667160216531 0.861509288119683 0.617694767792423 1.31099054175925 0.675738930304415 1.39471682947652 0.657143786074615 0.203940315889546 NA NA NA 0.058161784038747 96.5848267737861 a2436 loss_cnaBRCA17 1026 17-AAG HSP90 6 37 0 NA -0.0328596726647309 -1.03620886280333 1.0033491901386 1.73871850798938 1.76985420441691 0.568120053944519 0.577062466137116 0.566910645879534 0.203980549800811 NA NA NA 0.233416558027064 96.5848267737861 a2437 MLL3_mut 261 TL-1-85 MAP3K7 (TAK1) 3 46 2.32630161961136 NA 3.16051157350883 4.08117352414491 -0.92066195063608 1.0049392833419 1.20789383481759 0.767245816528968 0.916136890951704 0.762204362749411 0.204194578484867 NA NA NA 0.248384546868688 96.5848267737861 a2438 gain_cnaBRCA19 295 NVP-BHG712 EPHB4 4 45 2.32630161961136 NA 3.13625021415317 3.95341563347685 -0.817165419323678 1.00022792151421 1.23021522660699 0.671550103640085 0.816979212184556 0.664245899132195 0.204357820467387 NA NA NA 0.202397474982052 96.5848267737861 a2439 gain_cnaBRCA14_(RAD21) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 19 24 1.6094379124341 NA 3.27488671932193 2.68546400092183 0.589422718400102 1.25996836316169 1.64498940557545 0.396044929389494 0.467807554247662 0.358313990596133 0.204378605200458 NA NA NA 0.190763834356677 96.5848267737861 a2440 gain_cnaBRCA27_(CLTC,PPM1D) 205 BMS-708163 g-secretase 9 39 2.32630161961136 0.940007258491471 4.6365203656744 4.95653162960698 -0.320011263932582 0.890060235871271 0.616561631368774 0.476087764919449 0.359538884038928 0.519025589091804 0.204388239393188 NA NA NA 0.330591743562382 96.5848267737861 a2441 gain_cnaBRCA30_(CRNKL1,FOXA2) 273 CUDC-101 HDAC, EGFR 5 44 1.63315443905142 NA 0.820423457926078 -0.12290668961525 0.943330147541328 3.57415279119086 1.20349656839016 0.607358477932038 0.263931119527496 0.783824542851136 0.204417468391269 NA NA NA 0.588348500030662 96.5848267737861 a2442 gain_cnaBRCA10_(MDM2,NUP107) 1072 BMS-708163 g-secretase 3 43 1.6094379124341 NA 4.3636180532413 3.63685198163298 0.726766071608324 0.441808113728294 0.962269901435919 0.769184534987738 1.64498126907482 0.7552621884191 0.20444738174394 NA NA NA 0.0774800084644854 96.5848267737861 a2443 ASH1L_mut 1050 ZM-447439 AURKB 3 36 1.38629436111989 0.693147180559945 1.95628045960504 2.96556105005525 -1.00928059045021 1.23339110788279 1.30419622679425 0.776090599571326 0.818297281373072 0.773871730123806 0.204542913380549 NA NA NA 0.289135639908834 96.5848267737861 a2444 gain_cnaBRCA14_(RAD21) 1007 Docetaxel Microtubules 20 25 -4.38202663467388 NA -4.25947384997842 -4.84952429996614 0.590050449987724 1.63779002802468 1.43275768007706 0.386474219404959 0.3602723425416 0.411828502609031 0.204548989794172 NA NA NA 0.212172967041701 96.5848267737861 a2445 gain_cnaBRCA64_(SDHC) 271 VNLG/124 HDAC, RAR 8 41 1.63315443905142 NA 4.4864327510076 4.08607568702055 0.400357063987046 0.818502128367637 0.802829625960414 0.497224833687119 0.489133809322511 0.49868247389115 0.204588247842394 NA NA NA 0.233556440145692 96.5848267737861 a2446 BRCA1_mut 272 AR-42 HDAC 4 45 1.63315443905142 NA 1.07555041534069 0.058983571861086 1.0165668434796 1.04394343166511 1.54186397931867 0.671010428982139 0.973775793443287 0.659310326406876 0.204715520671187 NA NA NA 0.144793539732576 96.5848267737861 a2447 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 344 THZ-2-49 CDK9 15 34 2.99573227355399 NA 2.18888842830627 1.60721024555275 0.581678182753511 1.37044240392733 1.49544183861635 0.39859316618671 0.424445552098046 0.38896743941022 0.204767360586737 NA NA NA 0.19349525052332 96.5848267737861 a2448 gain_cnaBRCA31 55 A-770041 SRC family 3 9 1.63315443905142 NA 1.93541956218277 2.9614453058674 -1.02602574368463 0.704082546715801 1.21871161485174 0.904293603363695 1.45725206294424 0.841893792740667 0.204791393020954 NA NA NA 0.121398636944907 96.5848267737861 a2449 loss_cnaBRCA29_(MAP2K4) 164 JQ12 HDAC 7 40 1.63315443905142 NA 0.8491141937922 1.70541774237278 -0.85630354858058 1.32028067841482 1.66644683171274 0.527099152832755 0.648576899276212 0.513849906450654 0.204835169980525 NA NA NA 0.161063629630991 96.5848267737861 a2450 gain_cnaBRCA48 273 CUDC-101 HDAC, EGFR 5 44 1.63315443905142 NA 0.819620535011964 -0.12281544837501 0.942435983386974 1.43679870640148 1.56360981280337 0.60676251759862 0.655927639124441 0.602730921531695 0.204854323768569 NA NA NA 0.225468513367528 96.5848267737861 a2451 NF1_mut 1164 XMD8-92 MAP2K5 (ERK5) 3 23 2.30258509299405 NA 4.78800591480239 3.76663895265238 1.02136696215001 0.670977596351932 1.31811103120676 0.799959651087704 1.52220725058947 0.774871720188035 0.204876304156726 NA NA NA 0.0914444264433924 96.5848267737861 a2452 loss_cnaBRCA57 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 5 21 2.30258509299405 NA 5.19558920305993 4.56441143003793 0.631177773022 0.244158772791387 1.06086190352908 0.648328516102972 2.58511199825406 0.59496695179864 0.204979992958243 NA NA NA 0.0212114024986599 96.5848267737861 a2453 gain_cnaBRCA64_(SDHC) 152 CP466722 ATM 8 41 2.77258872223978 NA 2.29340503706975 2.81535868235675 -0.521953645286992 0.363889481535213 1.12894968583655 0.49666516055387 1.43437409370813 0.462335613212228 0.205089554590517 NA NA NA 0.0221551557710041 96.5848267737861 a2454 loss_cnaBRCA33 1527 GDC0941 (rescreen) PI3K 5 40 1.38629436111989 NA 1.60092581611322 0.903122094519914 0.697803721593307 0.796221699594875 1.17354460767618 0.610123892456781 0.87639375057017 0.594612013066192 0.20523719795368 NA NA NA 0.129664435393533 96.5848267737861 a2455 loss_cnaBRCA18 201 Epothilone B Microtubules 16 32 -3.44201937618241 NA -4.70400149898705 -4.00163613766608 -0.702365361320968 1.24056338287663 1.99780206352831 0.393151903852521 0.566166445838758 0.351569043872406 0.205561785603712 NA NA NA 0.142282137091143 96.5848267737861 a2456 loss_cnaBRCA17 1069 EHT 1864 Rac GTPases 9 37 2.30258509299405 NA 3.887826280326 3.48202598224188 0.405800298084126 0.778442205825271 0.864833250269907 0.47753610483245 0.521297914022934 0.469223746840768 0.205570742678429 NA NA NA 0.192981840276035 96.5848267737861 a2457 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 200 LAQ824 HDAC 15 33 0.0237165266173161 NA -3.06810375333873 -2.51008725376965 -0.558016499569082 1.14707696903814 1.49284181955522 0.399524970455908 0.486468227181822 0.373794793433197 0.205919637794681 NA NA NA 0.165595907707545 96.5848267737861 a2458 gain_cnaBRCA10_(MDM2,NUP107) 258 STF-62247 stimulates autophagy 5 44 2.32630161961136 NA 5.14817137674615 4.57205557909075 0.576115797655404 0.418560120841975 0.987019733038841 0.605196159037324 1.37642304884777 0.58369227926341 0.206005848154574 NA NA NA 0.0361242599445861 96.5848267737861 a2459 TP53_mut 177 GSK-650394 SGK3 37 10 2.77258872223978 NA 4.17774951806844 3.41018919594448 0.76756032212396 1.58094047526801 2.022851127573 0.457247136426365 0.485508679252353 0.379444790405743 0.206085181877615 NA NA NA 0.287827267066129 96.5848267737861 a2460 TP53_mut 1529 MLN4924 NEDD8-activating enzyme 28 9 0 NA 0.570574552958567 -0.257235822877764 0.827810375836331 1.50712495210884 2.15359494082198 0.493623875005161 0.549264594603135 0.384385364278564 0.206115381750652 NA NA NA 0.307490258595318 96.5848267737861 a2461 loss_cnaBRCA38 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 4 44 0.246860077931526 2.32630161961136 -1.26974101045785 -0.17360740417297 -1.09613360628488 1.16504713768298 1.66485853948162 0.669631483285552 0.940849147498742 0.658394440302525 0.206180653792882 NA NA NA 0.155496196151267 96.5848267737861 a2462 gain_cnaBRCA47_(EGFR) 1016 Temsirolimus MTOR 6 38 -1.6094379124341 NA -1.02931050143453 -1.86488261032804 0.835572108893508 1.50155160045933 1.47950090745147 0.563759367489141 0.556472457315423 0.564766202362683 0.206416115326966 NA NA NA 0.247089554569796 96.5848267737861 a2463 ARID1A_mut 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 5 42 2.99573227355399 NA 4.61343021116658 3.75649952041545 0.85693069075113 1.30050852815779 1.42359915879314 0.606422428153471 0.65891970117643 0.601946612189343 0.206461753661637 NA NA NA 0.224323505635127 96.5848267737861 a2464 gain_cnaBRCA16 223 ZSTK474 PI3K 16 33 1.63315443905142 2.32630161961136 0.53556351926179 1.09501647870016 -0.559452959438374 1.31707263419895 1.48509949570305 0.39023929379656 0.424770012611061 0.376710759822544 0.20647777772703 NA NA NA 0.190491410608958 96.5848267737861 a2465 gain_cnaBRCA62 235 QL-XII-47 BTK, BMX 10 39 2.32630161961136 NA 1.16976718943564 1.84610276286805 -0.676335573432409 1.24958532991461 1.54093587561602 0.454049579533704 0.541248010232823 0.438912211815454 0.206490492517614 NA NA NA 0.165000010838441 96.5848267737861 a2466 gain_cnaBRCA58_(CCND1) 202 GSK-1904529A IGF1R 9 39 0.0237165266173161 NA 2.50712231473693 2.11641721955627 0.390705095180653 0.421046732063311 0.886437855517203 0.473817839727427 0.927937602712244 0.440758585329923 0.206516628386661 NA NA NA 0.0607917890988488 96.5848267737861 a2467 loss_cnaBRCA57 1050 ZM-447439 AURKB 5 34 1.38629436111989 0.693147180559945 3.58610627380227 2.78525022975861 0.800856044043668 0.975386961836447 1.33478648400631 0.615697929759037 0.821064946916889 0.599988128168581 0.20661817817602 NA NA NA 0.151701871443642 96.5848267737861 a2468 ASH1L_mut 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 3 40 1.6094379124341 NA 1.85949359179113 2.94359385731015 -1.08410026551902 1.55327428879363 1.40364865584274 0.768148744761652 0.697945155817264 0.77234446170444 0.206620563158094 NA NA NA 0.349733470952128 96.5848267737861 a2469 gain_cnaBRCA62 1016 Temsirolimus MTOR 7 37 -1.6094379124341 NA -1.09217265047391 -1.87557280129068 0.783400150816774 1.10377742280113 1.53621810521119 0.528543862294762 0.709744677354141 0.50995372867909 0.206754763395111 NA NA NA 0.136595941298533 96.5848267737861 a2470 gain_cnaBRCA14_(RAD21) 230 GSK429286A ROCK2 21 28 2.99573227355399 2.32630161961136 5.59309660007989 5.26480882546717 0.328287774612722 0.848374724886742 0.916811789909007 0.369554317473562 0.386960814581727 0.358075428595115 0.206766518210612 NA NA NA 0.202041189173132 96.5848267737861 a2471 ASH1L_mut 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 3 43 2.30258509299405 NA 0.708834864145582 1.46231491885313 -0.753480054707552 0.959378244875627 0.986040514552644 0.765075343379895 0.785383719854136 0.764147155808702 0.20683158600262 NA NA NA 0.304672814199235 96.5848267737861 a2472 POLR2B_mut 190 Bleomycin DNA damage 3 45 4.15888308335967 NA 0.134974293340724 2.207960813862 -2.07298652052127 3.42844793716997 2.67955234273111 0.763134720988016 0.60464284670819 0.773631657595613 0.207027072487313 NA NA NA 0.405405016778193 96.5848267737861 a2473 gain_cnaBRCA58_(CCND1) 283 GSK2126458 PI3K, MTOR 10 38 -2.05572501506252 0.0237165266173161 -3.63790660731818 -2.90205561366206 -0.73585099365612 1.5123682494055 1.64254396086955 0.454818823816801 0.486555436445706 0.447994702842881 0.20706599055611 NA NA NA 0.198765481163143 96.5848267737861 a2474 loss_cnaBRCA34 306 TG101348 JAK2 5 43 2.32630161961136 NA 2.53680309460354 3.30489891270986 -0.768095818106322 1.2274634882333 1.27448800104081 0.604577062917719 0.625758587093983 0.602670105547527 0.207126971653017 NA NA NA 0.243723425636727 96.5848267737861 a2475 loss_cnaBRCA7_(FAS,PTEN) 1042 BIRB 0796 p38, JNK2 4 39 2.30258509299405 NA 4.92417804541916 4.30940760683324 0.61477043858592 0.683150207922197 0.929316096475466 0.672942309181032 0.899905220633315 0.661529958339799 0.207128908621647 NA NA NA 0.170318529553322 96.5848267737861 a2476 gain_cnaBRCA62 1005 Cisplatin DNA crosslinker 8 37 1.79175946922805 2.30258509299405 4.15040752355413 3.56622971980929 0.584177803744837 1.58008949674885 1.07238157761347 0.499237220797078 0.36971184540295 0.544748078426428 0.207267552375355 NA NA NA 0.346361161923225 96.5848267737861 a2477 CDH1_mut 1239 YK 4-279 RNA helicase A 4 38 2.30258509299405 NA 1.23333172177289 2.09568142313636 -0.862349701363473 0.494559266566421 1.32324958871832 0.673791020104173 1.74367312405349 0.651690889395047 0.20729085089246 NA NA NA 0.0276584385284116 96.5848267737861 a2478 gain_cnaBRCA14_(RAD21) 1194 SB-505124 TGFR1 (ALK5) 21 26 2.30258509299405 NA 4.57770750844266 4.23658075066235 0.341126757780303 0.96657191990594 0.859803180242184 0.375357132613802 0.352924340915573 0.396749820911592 0.207328528684334 NA NA NA 0.213725706072781 96.5848267737861 a2479 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 6 41 2.77258872223978 NA 5.50569686624172 4.93849240243009 0.567204463811627 0.618190409285487 1.05354343908052 0.559130829469621 0.917523881464304 0.538377861577926 0.207390195536426 NA NA NA 0.0893375474753353 96.5848267737861 a2480 gain_cnaBRCA48 229 LY317615 PRKCB (PKCbeta) 5 44 2.99573227355399 2.32630161961136 4.22439891670498 3.26019490783526 0.964204008869713 1.04429094113686 1.6403768008735 0.603259262129522 0.923309751035511 0.587794224080879 0.207436480020224 NA NA NA 0.114011797882621 96.5848267737861 a2481 loss_cnaBRCA28_(GPS2) 1373 Dabrafenib BRAF 4 42 2.30258509299405 NA 5.20377390714245 4.12038105766763 1.08339284947482 0.32839034649146 1.67404379897053 0.669488310585328 3.29910078371623 0.647171149369607 0.20744926219999 NA NA NA 0.00159747227844868 96.5848267737861 a2482 gain_cnaBRCA31 91 KIN001-135 IKKE 4 10 1.6094379124341 NA 3.92240109956273 3.61585326445721 0.306547835105519 0.213631174672787 0.432026951462872 0.787848000881647 1.43493961298041 0.709557202548424 0.207699553190505 NA NA NA 0.10476600501131 96.5848267737861 a2483 gain_cnaBRCA30_(CRNKL1,FOXA2) 295 NVP-BHG712 EPHB4 5 44 2.32630161961136 NA 4.54563337314882 3.81183039766652 0.733802975482299 1.58109280007538 1.17758360627024 0.602889220147628 0.464111262442858 0.623142995176771 0.207710645094479 NA NA NA 0.364972237425228 96.5848267737861 a2484 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 308 XL-880 MET 7 42 1.63315443905142 NA 2.55757707722245 1.72942122584593 0.828155851376524 1.64998207774984 1.57980011053897 0.521202786444762 0.501918089017016 0.524215592752421 0.207986956321799 NA NA NA 0.251456444543283 96.5848267737861 a2485 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 156 AZD6482 PI3Kbeta 9 38 1.63315443905142 NA 2.60740070117454 1.9220777468681 0.685322954306436 1.42464676562972 1.45197885504218 0.473564855715778 0.481047632887097 0.471992379177262 0.207995280209793 NA NA NA 0.219896685537588 96.5848267737861 a2486 loss_cnaBRCA29_(MAP2K4) 275 I-BET BRD2, BRD3, BRD4 7 42 2.99573227355399 NA 3.43762879579354 4.13915976992149 -0.701530974127948 1.06876923616364 1.38217893269147 0.52110471433227 0.656391436420924 0.507554382095725 0.208071092268493 NA NA NA 0.156547468821386 96.5848267737861 a2487 gain_cnaBRCA9_(KRAS) 229 LY317615 PRKCB (PKCbeta) 4 45 2.99573227355399 2.32630161961136 2.38111112244373 3.44546946752226 -1.06435834507853 1.23030707764161 1.62046396063114 0.665886423239321 0.865116005931469 0.656823212942036 0.208135188618636 NA NA NA 0.182751624940718 96.5848267737861 a2488 gain_cnaBRCA31 1020 Lenalidomide TNFA 14 31 1.6094379124341 NA 4.45395864283004 4.16475080516664 0.289207837663397 0.746134630097188 0.683223482164033 0.411486205048266 0.38760811520801 0.423299030571027 0.208143573820938 NA NA NA 0.229096245685258 96.5848267737861 a2489 BRCA2_mut 133 Doxorubicin DNA intercalating 6 42 0.0237165266173161 NA -1.91644870908914 -0.904101594168915 -1.01234711492023 1.91494927087898 1.804860075664 0.557107255742421 0.528654795359436 0.560900608623517 0.208188266494016 NA NA NA 0.265968420488776 96.5848267737861 a2490 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 5 40 -0.669430653942629 NA -4.78216837068823 -3.32419438016619 -1.45797399052203 1.07681838219956 2.50222541185814 0.606093120242768 1.35396461893965 0.582670923096152 0.208190650592677 NA NA NA 0.039780954320122 96.5848267737861 a2491 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1053 MK-2206 AKT1, AKT2 5 37 1.38629436111989 0.693147180559945 2.26668583954638 1.27593218977708 0.990753649769297 1.67118487618346 1.62114540842996 0.609237664886314 0.592845031024883 0.611144222237794 0.208393341272746 NA NA NA 0.266329115868629 96.5848267737861 a2492 loss_cnaBRCA33 1021 Axitinib PDGFR, KIT, VEGFR 5 40 0.693147180559945 NA 1.83870051949268 2.54030827826415 -0.701607758771467 1.13912938371453 1.1600555952229 0.605813540092108 0.615915776383215 0.604805288350561 0.208396683372306 NA NA NA 0.250635122770996 96.5848267737861 a2493 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 14 32 1.63315443905142 NA 2.38505338171289 1.74039442037053 0.644658961342363 1.61100634675598 1.56091928418748 0.409077821171187 0.400159169230145 0.412999549607034 0.208428783227807 NA NA NA 0.219491584487735 96.5848267737861 a2494 loss_cnaBRCA28_(GPS2) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 4 42 2.30258509299405 NA 2.01389460996195 1.35596351579223 0.657931094169714 0.484603801501513 1.01191762201115 0.667968416009618 1.35766804166859 0.650182465309872 0.208464147800433 NA NA NA 0.0630695537025415 96.5848267737861 a2495 BRCA2_mut 268 YM155 BIRC5 (Survivin) 6 43 1.63315443905142 NA -2.82391563189908 -3.70325182105742 0.87933618915834 1.38778521180235 1.60467664375349 0.555481473269727 0.633625565166765 0.547983416211189 0.20870889493417 NA NA NA 0.197165471239173 96.5848267737861 a2496 loss_cnaBRCA23 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 3 43 0 NA 2.10502284075964 0.551926236444355 1.55309660431529 0.885938457582182 2.07759411673604 0.761846151738239 1.75305247336689 0.747545726956162 0.208719805303515 NA NA NA 0.0643898176123585 96.5848267737861 a2497 gain_cnaBRCA9_(KRAS) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 4 41 -0.669430653942629 NA -4.95140357993536 -3.34324396927677 -1.6081596106586 2.95790666902277 2.35900925967081 0.668496669197266 0.543681660919307 0.681709749152494 0.208739003572445 NA NA NA 0.360822152046495 96.5848267737861 a2498 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1004 Vinblastine Microtubules 6 39 -2.30258509299405 NA -2.8396901482162 -3.55030961833245 0.710619470116251 1.15092580197164 1.2847318626494 0.5595880048581 0.617432912615995 0.553126680185854 0.208785144893817 NA NA NA 0.208075437361678 96.5848267737861 a2499 CDH1_mut 272 AR-42 HDAC 4 45 1.63315443905142 NA -0.783205900247105 0.22420635546889 -1.00741225571599 1.78103249672234 1.49563339687567 0.664758025079015 0.565633843048878 0.673568976074246 0.208893972824114 NA NA NA 0.344293744681718 96.5848267737861 a2500 gain_cnaBRCA10_(MDM2,NUP107) 1066 AZD6482 PI3Kbeta 3 40 1.6094379124341 NA 2.97849140588558 1.89133985538658 1.08715155049899 0.739969818712092 1.44905287989724 0.764153913172153 1.46918363831537 0.75024974283622 0.208945186891285 NA NA NA 0.102554134991563 96.5848267737861 a2501 loss_cnaBRCA22_(SYNCRIP,ZNF292) 288 KIN001-055 JAK3, MNK1 19 30 2.32630161961136 NA 4.53263942760527 4.21637311223786 0.316266315367409 0.891428620686872 0.818395582290522 0.373347417282521 0.354785911095963 0.386446752904316 0.209150928165913 NA NA NA 0.219838888562078 96.5848267737861 a2502 MLL3_mut 1268 XAV 939 TNKS1 (tankyrase-1) 3 44 1.6094379124341 NA 2.9996041536932 3.70656804022725 -0.706963886534056 0.540922550471357 0.944125461754045 0.760237474688191 1.30695953777119 0.748802902975016 0.20918564947108 NA NA NA 0.13428166910778 96.5848267737861 a2503 gain_cnaBRCA14_(RAD21) 167 OSU-03012 PDPK1 (PDK1) 21 27 2.77258872223978 NA 2.49234666342096 2.05791531082247 0.434431352598494 1.08123645580652 1.23822866417783 0.370499206616508 0.401791255063114 0.350849051687032 0.209280434515301 NA NA NA 0.201713466571326 96.5848267737861 a2504 PIK3CA_mut 258 STF-62247 stimulates autophagy 17 32 2.32630161961136 NA 4.86838571618354 4.50464828714386 0.363737429039681 1.03167638692508 0.908443627432774 0.382001918938064 0.352569307245465 0.400396258012826 0.209342298268957 NA NA NA 0.230921775130867 96.5848267737861 a2505 gain_cnaBRCA16 228 KIN001-102 AKT1 16 33 2.32630161961136 NA 1.57985644951332 2.12011433366098 -0.540257884147653 1.43970209624069 1.37113578195691 0.387730439104172 0.375256718426931 0.394022161230879 0.209361002388567 NA NA NA 0.221119063160708 96.5848267737861 a2506 PTEN_mut 1239 YK 4-279 RNA helicase A 7 35 2.30258509299405 NA 1.45024361598868 2.1262147329815 -0.675971116992827 0.825936039574716 1.3444130960842 0.528061320840164 0.818430344002052 0.502800157899153 0.209529179703722 NA NA NA 0.102886554371104 96.5848267737861 a2507 gain_cnaBRCA27_(CLTC,PPM1D) 272 AR-42 HDAC 9 40 1.63315443905142 NA -0.438593871731363 0.272595181017347 -0.71118905274871 1.48775538434254 1.52117928563853 0.469263784006832 0.47802821635426 0.467524807537846 0.209648355102063 NA NA NA 0.221107967263344 96.5848267737861 a2508 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 5 43 0.246860077931526 2.32630161961136 -1.14654116409589 -0.162441488487503 -0.98409967560839 0.641485763893577 1.70209312718882 0.601024628893546 1.53409433380918 0.578170289209575 0.209762314522021 NA NA NA 0.0251772672129961 96.5848267737861 a2509 gain_cnaBRCA30_(CRNKL1,FOXA2) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 5 43 2.32630161961136 NA 5.32946907834087 4.91535334826047 0.414115730080399 1.29099051105542 0.60115823981492 0.600930221630585 0.320773643597 0.688863102347053 0.209832690242475 NA NA NA 0.516008577967629 96.5848267737861 a2510 gain_cnaBRCA19 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 4 45 3.68887945411394 NA 2.73823290125341 3.52356756933848 -0.785334668085074 0.501921799157244 1.21654327761084 0.663352059019708 1.56465542919972 0.645546017587952 0.209842298068493 NA NA NA 0.0396972042102735 96.5848267737861 a2511 gain_cnaBRCA15 55 A-770041 SRC family 6 6 1.63315443905142 NA 2.26523550480137 3.14464223509112 -0.879406730289743 1.37636771343064 0.830681566179337 0.77361207652217 0.63893298404813 1.05865685010264 0.209917728572644 NA NA NA 0.216142508432426 96.5848267737861 a2512 loss_cnaBRCA18 223 ZSTK474 PI3K 16 33 1.63315443905142 2.32630161961136 0.538375871570932 1.09365291394422 -0.555277042373284 0.914579787827207 1.62115100542137 0.387225910898851 0.607138983130681 0.342520246736026 0.209944433918759 NA NA NA 0.133194850312365 96.5848267737861 a2513 gain_cnaBRCA10_(MDM2,NUP107) 211 TL-2-105 CRAF 5 44 2.32630161961136 1.63315443905142 4.48817310537909 3.84157426278565 0.646598842593436 0.866248070806031 1.09564430263147 0.599800429873036 0.746436112685117 0.590153977016505 0.210009727712778 NA NA NA 0.179368014254457 96.5848267737861 a2514 gain_cnaBRCA10_(MDM2,NUP107) 179 5-Fluorouracil DNA antimetabolite 5 44 3.46573590279973 NA 4.90481409746516 3.94337016425723 0.961443933207938 1.46013070222068 1.61559925883299 0.599794698076234 0.658464294837236 0.595100504008912 0.210014011671392 NA NA NA 0.224302698274869 96.5848267737861 a2515 gain_cnaBRCA13_(FGFR1,WHSC1L1) 119 Lapatinib ERBB2, EGFR 3 10 0.693147180559945 NA 2.89550606271723 1.00624944924341 1.88925661347382 0.509337444851957 2.37166942667847 0.876188652209702 3.70924351344902 0.796593569163528 0.210109779126785 NA NA NA 0.039154225750091 96.5848267737861 a2516 gain_cnaBRCA27_(CLTC,PPM1D) 207 AS601245 JNK 9 39 2.07944154167984 NA 1.78083810450474 2.37820746899182 -0.597369364487078 1.55515847595047 1.2027434089505 0.469973121438386 0.384121215763546 0.496672324322556 0.21015946604682 NA NA NA 0.304642714076634 96.5848267737861 a2517 loss_cnaBRCA7_(FAS,PTEN) 1170 CCT018159 HSP90 4 39 2.30258509299405 NA 4.05703660503657 3.26957628771515 0.787460317321415 0.999345028077556 1.19131118625425 0.668287420530569 0.7879764197519 0.66100304136098 0.210227299657742 NA NA NA 0.216117853702307 96.5848267737861 a2518 loss_cnaBRCA28_(GPS2) 1069 EHT 1864 Rac GTPases 4 42 2.30258509299405 NA 3.04503065055196 3.61060179199228 -0.565571141440316 1.0663766156439 0.83206896021872 0.665300738091908 0.53036716404252 0.679716668305531 0.210254440618251 NA NA NA 0.370904556834157 96.5848267737861 a2519 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1066 AZD6482 PI3Kbeta 5 38 1.6094379124341 NA 2.72834710927047 1.86703507596757 0.861312033302896 1.04293173968732 1.45801644440648 0.605338147859387 0.825856573855086 0.590742331204307 0.210382574544269 NA NA NA 0.148469749924572 96.5848267737861 a2520 POLR2B_mut 1033 Vismodegib SMO 3 42 2.30258509299405 NA 4.21074608727229 4.79899088985399 -0.588244802581705 1.19481539495528 0.747785626528451 0.759690472443077 0.492331120828687 0.786648982961327 0.210489287674926 NA NA NA 0.484714814575089 96.5848267737861 a2521 POLR2B_mut 1038 NU-7441 PRKDC (DNAPK) 3 40 0.693147180559945 NA 2.23102256792567 2.94250319925395 -0.711480631328281 1.3727013873269 0.906426000877972 0.761280597356186 0.518306922318896 0.784929636439306 0.210629302179265 NA NA NA 0.465165665747403 96.5848267737861 a2522 loss_cnaBRCA33 55 A-770041 SRC family 4 8 1.63315443905142 NA 3.32586074954938 2.39447793014468 0.931382819404698 1.00705165972935 1.18842304319324 0.819119678854763 0.92486101423537 0.783713194337022 0.210646393660005 NA NA NA 0.197663953979184 96.5848267737861 a2523 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 134 Etoposide TOP2 9 38 2.77258872223978 NA 3.29072774102717 2.28440079173315 1.00632694929401 1.15557076215709 2.29561711531835 0.470719870780018 0.870848399985055 0.438368812716602 0.210692092719503 NA NA NA 0.0719679447392678 96.5848267737861 a2524 loss_cnaBRCA42 328 SNX-2112 HSP90 3 45 0.940007258491471 NA -1.01621357141018 0.512803525304031 -1.52901709671421 2.14898912930032 2.01422922517111 0.756836018520274 0.711505272812633 0.7591077905169 0.210735467697453 NA NA NA 0.342302297946067 96.5848267737861 a2525 gain_cnaBRCA58_(CCND1) 1052 RO-3306 CDK1 8 35 1.6094379124341 NA 4.00734734556682 3.41557644981488 0.591770895751938 0.867780705793699 1.24405005501548 0.498008949228173 0.681935991202623 0.475680936925462 0.210958337683501 NA NA NA 0.133227295487637 96.5848267737861 a2526 gain_cnaBRCA16 1049 PD-173074 FGFR1, FGFR3 14 29 0.693147180559945 NA 3.25297636884127 2.78559249661684 0.467383872224425 1.01137084817089 1.18164365523625 0.413454898476084 0.46212907270336 0.395537072579618 0.211087224150652 NA NA NA 0.189589709459235 96.5848267737861 a2527 loss_cnaBRCA23 274 PXD101, Belinostat HDAC 3 45 2.99573227355399 NA -0.378736878396904 0.741519360923385 -1.12025623932029 0.607612105462793 1.50914213737409 0.756215638135495 1.84370296320386 0.742313272936332 0.211103388433073 NA NA NA 0.0554566109595609 96.5848267737861 a2528 NF1_mut 1019 Bosutinib SRC, ABL, TEC 4 41 0.693147180559945 NA 3.22265103637728 2.60795926910829 0.614691767268989 0.972587411642206 0.920808210198557 0.664880381133933 0.632016988818606 0.667556783769816 0.21116662115835 NA NA NA 0.299994685244336 96.5848267737861 a2529 gain_cnaBRCA63 281 CH5424802 ALK 7 41 1.63315443905142 NA 4.04228444799266 3.49550026620298 0.54678418178968 1.00818618444724 1.06160901336709 0.518379929854458 0.542344450087327 0.515052316723888 0.211334281754147 NA NA NA 0.222863512983703 96.5848267737861 a2530 gain_cnaBRCA48 154 CHIR-99021 GSK3B 5 42 0.940007258491471 NA 2.79457791716072 3.33268197141048 -0.538104054249763 0.964075904542044 0.890330180556652 0.599805530789398 0.558155277727197 0.604387075717606 0.211369089335539 NA NA NA 0.289331770852448 96.5848267737861 a2531 ASH1L_mut 261 TL-1-85 MAP3K7 (TAK1) 3 46 2.32630161961136 NA 3.17410892189424 4.08028674055456 -0.906177818660326 1.05776265348065 1.20657403901513 0.754759835711924 0.856692960068571 0.751033744601364 0.211528396802913 NA NA NA 0.272467207232427 96.5848267737861 a2532 ASH1L_mut 1011 ABT-263 BCL2, BCL2L1, BCL2L2 3 40 0.693147180559945 NA 2.85033841957352 1.59431766680466 1.25602075276885 0.36809666336348 1.69300564911573 0.759752708044013 3.41220358068985 0.741888104995329 0.211528969532384 NA NA NA 0.0032431590179057 96.5848267737861 a2533 loss_cnaBRCA60 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 3 43 1.63315443905142 NA 0.821368001015058 2.01440150680912 -1.19303350579407 1.04994538193581 1.59702950743213 0.756863278233591 1.13628149265673 0.747032850828378 0.211658769938834 NA NA NA 0.175625913134708 96.5848267737861 a2534 loss_cnaBRCA7_(FAS,PTEN) 255 CP724714 ERBB2 4 44 2.32630161961136 NA 4.80494891527857 3.71195266430513 1.09299625097344 0.467954491685116 1.70488284802569 0.661348603823047 2.33568919712156 0.641097569982103 0.211750283843508 NA NA NA 0.00758767388910092 96.5848267737861 a2535 gain_cnaBRCA48 173 FH535 unknown 5 43 3.46573590279973 NA 0.893348124970786 1.6520271335957 -0.75867900862491 1.15258525370517 1.27839139945282 0.598352135347969 0.658241120286779 0.593463792817786 0.211761349663895 NA NA NA 0.224765838598806 96.5848267737861 a2536 gain_cnaBRCA30_(CRNKL1,FOXA2) 305 TPCA-1 IKK 5 44 2.99573227355399 NA 4.91220010583216 4.09493162245701 0.817268483375146 0.833617440388115 1.40755569666118 0.597367870344117 0.98038793789468 0.580629587385966 0.211833699529676 NA NA NA 0.0987869133209707 96.5848267737861 a2537 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1053 MK-2206 AKT1, AKT2 4 38 1.38629436111989 0.693147180559945 2.37533306847051 1.29056810383163 1.08476496463888 1.96778163272876 1.59587377061436 0.666842285980263 0.551262877240404 0.679731056812394 0.211921669847642 NA NA NA 0.355574938388007 96.5848267737861 a2538 loss_cnaBRCA7_(FAS,PTEN) 1529 MLN4924 NEDD8-activating enzyme 3 34 0 NA 1.55003652401604 0.265025161908585 1.28501136210746 1.67705569555334 1.67804330306375 0.76580536734493 0.766230582272623 0.765779619489735 0.211934356585295 NA NA NA 0.313914158537753 96.5848267737861 a2539 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1241 CHIR-99021 GSK3B 6 40 2.30258509299405 NA 4.69813158584679 4.16149041848297 0.536641167363819 0.613067470595578 1.0044019082225 0.554419649280967 0.875337859375392 0.534289275010955 0.212039166476508 NA NA NA 0.101464022679765 96.5848267737861 a2540 BRCA2_mut 222 BX-912 PDPK1 (PDK1) 6 43 2.32630161961136 NA 3.15915846731668 3.9848908699935 -0.825732402676822 1.0067582450791 1.54578346498731 0.551337265468013 0.820189361957446 0.534183746546676 0.212067575752881 NA NA NA 0.116436795298545 96.5848267737861 a2541 PIK3CA_mut 1161 ZG-10 IRAK1 10 16 2.30258509299405 NA 2.41295174162864 1.70194738134741 0.711004360281231 1.80873120616084 1.03275102230944 0.516711614331695 0.393095645090564 0.688456699555023 0.212156648737509 NA NA NA 0.278114040050851 96.5848267737861 a2542 loss_cnaBRCA28_(GPS2) 1241 CHIR-99021 GSK3B 4 42 2.30258509299405 NA 4.8168617934976 4.17573712096212 0.641124672535477 0.947649383563523 0.969417430179709 0.662353912757438 0.676542066776431 0.661350469442896 0.212245421773081 NA NA NA 0.27308729837124 96.5848267737861 a2543 gain_cnaBRCA62 1239 YK 4-279 RNA helicase A 7 35 2.30258509299405 NA 2.57357719032314 1.90154801811461 0.672029172208528 2.06691984043496 1.08389624801876 0.524857828144208 0.325135575682077 0.620012453624524 0.212252120463894 NA NA NA 0.431271325988117 96.5848267737861 a2544 ASH1L_mut 1026 17-AAG HSP90 3 40 0 NA 0.35019949715071 -0.989687111279093 1.3398866084298 3.51688226348648 1.62773959474446 0.758120514669928 0.380987052748675 0.823157839715848 0.212493232974132 NA NA NA 0.578068534893605 96.5848267737861 a2545 gain_cnaBRCA58_(CCND1) 1259 BMN-673 PARP1 9 37 2.30258509299405 NA 3.88847073515785 3.16374360125467 0.724727133903178 0.789454333534328 1.66310115720278 0.470133484610358 0.918010204160422 0.43576852241635 0.212557198875789 NA NA NA 0.0666486369025632 96.5848267737861 a2546 gain_cnaBRCA48 204 Tipifarnib Farnesyl-transferase (FNTA) 5 43 2.77258872223978 NA 0.817840000179611 1.71324821672478 -0.895408216545168 1.58008799025647 1.49185906122131 0.59704341098783 0.566682502535718 0.600196251656738 0.212745452509937 NA NA NA 0.283090413341017 96.5848267737861 a2547 MACF1_mut 1091 BMS-536924 IGF1R 3 44 1.38629436111989 NA 3.78857141428802 2.97112477407446 0.817446640213559 1.23376598209874 1.07641059283219 0.75417904046058 0.66256214879828 0.759418985336015 0.212774301472687 NA NA NA 0.369859311973345 96.5848267737861 a2548 loss_cnaBRCA22_(SYNCRIP,ZNF292) 256 JW-7-24-1 LCK 18 30 2.32630161961136 NA 1.56624591802001 2.00036305501148 -0.434117136991465 1.23088801426542 1.10450655497801 0.376567174804091 0.352686135505625 0.393041702681528 0.212937878341609 NA NA NA 0.227911868872495 96.5848267737861 a2549 gain_cnaBRCA27_(CLTC,PPM1D) 167 OSU-03012 PDPK1 (PDK1) 9 39 2.77258872223978 NA 1.8029212352881 2.35068467196036 -0.54776343667226 1.14260005093793 1.17916043998024 0.467022695056288 0.479400850912455 0.464536816280438 0.212987386571972 NA NA NA 0.221341741194319 96.5848267737861 a2550 loss_cnaBRCA7_(FAS,PTEN) 1143 HG-5-88-01 EGFR, ADCK4 3 23 2.30258509299405 NA 5.20124973067609 4.44705452343614 0.754195207239956 0.201649266382275 1.0012347200014 0.785313196695535 3.74013365270667 0.753265135710537 0.213013512557761 NA NA NA 0.00538801929716051 96.5848267737861 a2551 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1058 GDC0941 PI3K (class 1) 15 28 1.38629436111989 0.693147180559945 0.984467191757748 1.53968223621742 -0.555215044459671 1.16787736785035 1.46645371477335 0.404726776658059 0.475405260641042 0.378610684310266 0.213053641975863 NA NA NA 0.183944842472238 96.5848267737861 a2552 loss_cnaBRCA18 330 XMD13-2 RIPK 15 33 2.32630161961136 NA 3.39526745198707 3.86909114993454 -0.473823697947468 0.725026744693666 1.36293502958399 0.393187952120282 0.653525820137387 0.34764951201826 0.213079316426158 NA NA NA 0.123978461832926 96.5848267737861 a2553 gain_cnaBRCA14_(RAD21) 1529 MLN4924 NEDD8-activating enzyme 16 21 0 NA 0.770035646554183 0.0638283205749086 0.706207325979274 1.8562436573235 1.53110909623779 0.420816481669827 0.380449691069946 0.461239063705225 0.213124790823364 NA NA NA 0.226816921047623 96.5848267737861 a2554 BRCA1_mut 271 VNLG/124 HDAC, RAR 4 45 1.63315443905142 NA 4.63851240212416 4.10814479038682 0.530367611737341 0.164986456827969 0.831605768325246 0.658264023697373 3.214613016936 0.637763267089209 0.213301069890577 NA NA NA 0.00160841957880617 96.5848267737861 a2555 ASH1L_mut 272 AR-42 HDAC 3 46 1.63315443905142 NA 1.21185789642458 0.0721932327356059 1.13966466368897 0.84677394960755 1.5389520890792 0.75178264774794 1.34589008579819 0.740545902485415 0.213305768115673 NA NA NA 0.126415453787142 96.5848267737861 a2556 gain_cnaBRCA30_(CRNKL1,FOXA2) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 39 1.6094379124341 NA 3.5221222403882 2.46941515740677 1.05270708298143 2.24052515181174 1.52286443963543 0.663572706940366 0.469848366634128 0.691267755410616 0.213400833726115 NA NA NA 0.420755306989029 96.5848267737861 a2557 gain_cnaBRCA15 1194 SB-505124 TGFR1 (ALK5) 22 25 2.30258509299405 NA 4.56742719296905 4.23198235796792 0.335444835001131 0.951529839392716 0.870542348505077 0.368930979627838 0.352532123653861 0.385328566240537 0.213431870195478 NA NA NA 0.216349506225636 96.5848267737861 a2558 loss_cnaBRCA29_(MAP2K4) 273 CUDC-101 HDAC, EGFR 7 42 1.63315443905142 NA -0.712514684523749 0.0876625175768009 -0.80017720210055 0.952471260009384 1.62368202888321 0.514841443813501 0.840106400788058 0.492816443038988 0.213497235892293 NA NA NA 0.0915497602163622 96.5848267737861 a2559 gain_cnaBRCA16 1032 Afatinib ERBB2, EGFR 15 30 -0.693147180559945 NA -0.192226189707488 0.531820642446454 -0.724046832153942 2.08478014204662 1.66659530534521 0.399283008986138 0.347301289738469 0.434446700906773 0.213521895999242 NA NA NA 0.25348559227412 96.5848267737861 a2560 loss_cnaBRCA18 1230 IOX2 EGLN1 15 32 -2.30258509299405 NA 0.423498603323174 0.16788338839652 0.255615214926653 0.509220494258825 0.701114255190173 0.394750113202729 0.501973541537647 0.36458425004826 0.213622099447405 NA NA NA 0.165568223726452 96.5848267737861 a2561 TP53_mut 1161 ZG-10 IRAK1 23 3 2.30258509299405 NA 1.85088389667498 2.9301152981068 -1.07923140143182 1.39990820424322 1.08345430662298 0.784143389408911 0.770930121104082 0.996102368909009 0.213673986707571 NA NA NA 0.217309918935853 96.5848267737861 a2562 BRCA1_mut 261 TL-1-85 MAP3K7 (TAK1) 4 45 2.32630161961136 NA 4.75007634295372 3.96033803243061 0.789738310523106 1.02220382902391 1.21202796609426 0.657672194526774 0.77258398775244 0.651584231235211 0.213706128503705 NA NA NA 0.222630650042263 96.5848267737861 a2563 gain_cnaBRCA13_(FGFR1,WHSC1L1) 273 CUDC-101 HDAC, EGFR 11 38 1.63315443905142 NA 0.493346133739498 -0.177173276962502 0.670519410702 2.10906992703148 1.36617334778644 0.431406314699539 0.317921848919328 0.490801121093761 0.21388360417545 NA NA NA 0.338245462329205 96.606262146561 a2564 gain_cnaBRCA16 1031 Elesclomol HSP70 15 29 -1.6094379124341 NA -2.51020166794564 -3.21932600296304 0.709124335017396 1.87436323457468 1.71066313045466 0.401334539556597 0.378328128687557 0.414531839959003 0.213947900660778 NA NA NA 0.231481291983103 96.606262146561 a2565 loss_cnaBRCA23 309 Y-39983 ROCK 3 46 2.99573227355399 NA 5.69133930559742 4.88565320692525 0.805686098672163 0.524309682898338 1.09145454076913 0.750562999749537 1.53666072733657 0.738176505367244 0.214037097887719 NA NA NA 0.092885672289364 96.606262146561 a2566 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 253 XMD14-99 EPHB3, CAMK1 5 43 2.32630161961136 NA 4.52474379249406 4.98058533414494 -0.45584154165088 0.67323156491028 0.7741133234188 0.595195424157173 0.677094725514881 0.588856344233552 0.214140859919497 NA NA NA 0.214437306948752 96.606262146561 a2567 MLL3_mut 275 I-BET BRD2, BRD3, BRD4 3 46 2.99573227355399 NA 3.09022312071239 4.10081396837218 -1.01059084765979 0.576786313978137 1.37106593655109 0.75034049436732 1.75210614948484 0.737084060451479 0.214170718481926 NA NA NA 0.0649074456364657 96.606262146561 a2568 loss_cnaBRCA60 152 CP466722 ATM 3 46 2.77258872223978 NA 1.98955010878972 2.77844121623512 -0.788891107445396 1.01740508016657 1.0531296270239 0.750157365075051 0.775395290257677 0.749092122376965 0.214280739228949 NA NA NA 0.309517934702125 96.6182507605919 a2569 TP53_mut 1023 GW 441756 NTRK1 35 10 0.693147180559945 NA 2.48867656484816 1.90642258205764 0.582253982790526 1.15405702298472 1.70374771741372 0.451829310147582 0.504527914300673 0.341748943719428 0.214432128974308 NA NA NA 0.330527197048868 96.6488758814135 a2570 loss_cnaBRCA42 257 NPK76-II-72-1 PLK3 3 46 2.32630161961136 NA 2.3738530095914 3.55103251146914 -1.17717950187773 1.74963464069641 1.5618209379393 0.749666608764475 0.672814469087774 0.753722448766075 0.214575784104304 NA NA NA 0.363889789076361 96.66074112876 a2571 gain_cnaBRCA31 1494 SN-38 TOP1 15 33 -2.99573227355399 NA -2.85449252652773 -3.50801395692171 0.653521430393974 1.82873427352575 1.59232278761583 0.391840444067375 0.35736270701265 0.4104201958778 0.214625412766251 NA NA NA 0.24427396330693 96.66074112876 a2572 gain_cnaBRCA58_(CCND1) 226 GSK1070916 AURKB 10 39 0.940007258491471 2.32630161961136 3.08857383412238 2.22840254897511 0.860171285147267 1.17458545342397 2.06904861630819 0.445655175753082 0.732319034464311 0.415732756769183 0.214862879475288 NA NA NA 0.0961730311876604 96.705851214967 a2573 CDH1_mut 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 4 39 -1.38629436111989 0.693147180559945 -1.65516221649462 -2.27849565621162 0.623333439717001 1.82458307107797 0.8340110899204 0.661374589198281 0.341630616658487 0.747392267621397 0.214892611776587 NA NA NA 0.545604345579522 96.705851214967 a2574 ASH1L_mut 1243 piperlongumine Increases ROS levels 3 44 2.30258509299405 NA 1.11635623643971 1.75073973651294 -0.63438350007323 1.01706579297807 0.83660943633054 0.750351870208161 0.623738901114444 0.758279159335933 0.215064850568532 NA NA NA 0.393349117230399 96.731709288613 a2575 loss_cnaBRCA18 192 LFM-A13 BTK 16 32 2.77258872223978 NA 4.58280857154671 4.90180090061966 -0.318992329072952 0.833526646601838 0.826816570605974 0.384786788690362 0.382702017234164 0.385807856800889 0.215203505112321 NA NA NA 0.219828905452752 96.731709288613 a2576 gain_cnaBRCA9_(KRAS) 190 Bleomycin DNA damage 4 44 4.15888308335967 NA 0.443407967285637 2.22703471896976 -1.78362675168413 3.2005453998608 2.68119764897302 0.656204802041846 0.557288377087762 0.665235087151189 0.215265204017512 NA NA NA 0.350594007396012 96.731709288613 a2577 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 308 XL-880 MET 6 43 1.63315443905142 NA 1.08403577212047 1.95429107891543 -0.870255306794965 1.14789518956252 1.63445225556679 0.547404438730281 0.758131330027291 0.532444617963576 0.215292065045175 NA NA NA 0.139027792855803 96.731709288613 a2578 loss_cnaBRCA57 1061 SB590885 BRAF 5 37 1.6094379124341 NA 4.58062556069165 3.93505847151253 0.645567089179121 0.647348939409688 1.11379585793793 0.599809569678918 0.997247465590673 0.579609885041516 0.21538135016281 NA NA NA 0.0976403915131816 96.731709288613 a2579 gain_cnaBRCA27_(CLTC,PPM1D) 151 QS11 ARFGAP 9 39 2.32630161961136 NA 3.20679056746101 3.88821742936203 -0.681426861901016 1.58041211960273 1.44209614607279 0.464475751170369 0.431170359584629 0.472525263836759 0.215451315532717 NA NA NA 0.260495443575301 96.731709288613 a2580 gain_cnaBRCA61_(NOTCH2) 185 OSI-906 IGF1R 3 45 0.940007258491471 NA 3.67785686119575 2.84119878269007 0.83665807850568 0.147341485457734 1.14215564119103 0.748705631333167 5.6783605507064 0.732525453040025 0.215595364419748 NA NA NA 0.000135531468745556 96.7443217214978 a2581 gain_cnaBRCA16 87 GW843682X PLK1 3 9 -1.36257783450257 NA -3.13467050750349 -1.5080461519231 -1.62662435558039 1.81319181562313 1.85386412378343 0.881256450508121 0.897105502884361 0.877423719846697 0.215646510374977 NA NA NA 0.260554825609295 96.7443217214978 a2582 gain_cnaBRCA12_(TERT) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 9 40 1.63315443905142 NA 3.20225544237151 3.66089722575352 -0.458641783382009 1.14711385618411 0.955753714680796 0.462835645618968 0.399822372390904 0.479874444992544 0.215853571672428 NA NA NA 0.2891903665741 96.7880477331332 a2583 loss_cnaBRCA18 184 BMS-754807 IGF1R 16 32 0.940007258491471 NA 1.20096296018841 1.83982195192561 -0.638858991737207 1.36953636365335 1.78795032990945 0.384133325685857 0.466478297832851 0.357313612716277 0.215970640357569 NA NA NA 0.178390342673881 96.7880477331332 a2584 gain_cnaBRCA16 156 AZD6482 PI3Kbeta 16 31 1.63315443905142 NA 2.42207311552255 1.86298034978058 0.559092765741973 1.2791662831561 1.52552441346224 0.386095256326864 0.437075908819702 0.366492178563756 0.216224950264936 NA NA NA 0.192761881894908 96.7880477331332 a2585 PIK3CA_mut 1529 MLN4924 NEDD8-activating enzyme 12 25 0 NA 0.870871849070177 0.128420115523915 0.742451733546262 1.93647588451015 1.54624152749003 0.442280357425524 0.383403552548795 0.480165433631487 0.21622664022065 NA NA NA 0.260352784346338 96.7880477331332 a2586 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 14 32 0 NA 1.22357892859699 0.403680990282137 0.819897938314848 1.86678022870208 2.10814551696564 0.401948629704707 0.439204318595606 0.388919043641241 0.216325217908981 NA NA NA 0.198681964589095 96.7880477331332 a2587 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1030 KU-55933 ATM 8 34 2.30258509299405 NA 4.58694534847623 4.13650029777063 0.450445050705603 0.508129351869681 0.977002246673159 0.493633076649806 0.886477132344695 0.461048121679799 0.216325552661798 NA NA NA 0.0808645323995675 96.7880477331332 a2588 gain_cnaBRCA30_(CRNKL1,FOXA2) 288 KIN001-055 JAK3, MNK1 5 44 2.32630161961136 NA 3.8888861901449 4.39015708047526 -0.50127089033036 1.11745320960199 0.81793213814656 0.591432225098722 0.448583337559969 0.612851442011122 0.216333888395928 NA NA NA 0.379519633451023 96.7880477331332 a2589 loss_cnaBRCA29_(MAP2K4) 1005 Cisplatin DNA crosslinker 6 39 1.79175946922805 2.30258509299405 4.2284265745197 3.58418462498099 0.644241949538707 1.09170338868101 1.18103754615927 0.550163889050651 0.59012544636055 0.545488119013471 0.216412691580518 NA NA NA 0.225393965059109 96.7880477331332 a2590 ASH1L_mut 231 FMK RSK 3 46 2.99573227355399 2.32630161961136 5.17715302225365 5.61610426313579 -0.438951240882148 0.261961211405094 0.59846277192342 0.746415234774535 1.67563449003662 0.733464572025738 0.216538163736974 NA NA NA 0.0736911796000777 96.7961379173673 a2591 loss_cnaBRCA20 263 FR-180204 ERK 3 46 2.99573227355399 NA 5.86692957101259 5.32468632317562 0.542243247836962 0.265733549107889 0.740413292532839 0.74631648356831 2.04055246188282 0.732352124557397 0.21659797335167 NA NA NA 0.0392869308612962 96.7961379173673 a2592 gain_cnaBRCA8_(CHD4,WNK1) 165 DMOG Prolyl-4-Hydroxylase 3 43 8.29404964010203 NA 8.63361042331391 7.49577384447835 1.13783657883555 1.69756330872624 1.51139095141769 0.748405358146954 0.670276373780323 0.752840671547129 0.216718011881261 NA NA NA 0.365387547858176 96.8124174218025 a2593 gain_cnaBRCA64_(SDHC) 1194 SB-505124 TGFR1 (ALK5) 9 38 2.30258509299405 NA 4.73036658872681 4.30814889199936 0.422217696727454 1.08291996492269 0.867423939550155 0.464243890695587 0.389888182325273 0.486748955702578 0.216928126487663 NA NA NA 0.30004185796252 96.8327677577868 a2594 loss_cnaBRCA36_(FAT1,IRF2) 305 TPCA-1 IKK 9 40 2.99573227355399 NA 3.66248192448798 4.29439136492193 -0.631909440433952 1.39990612470337 1.36211649237433 0.461712020149059 0.45139415371002 0.463917325699846 0.216952109388033 NA NA NA 0.243096285843663 96.8327677577868 a2595 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 310 YM201636 FYV1 9 40 1.63315443905142 NA 2.79450248282718 2.3292046090182 0.465297873808986 0.673952513306203 1.06352515142136 0.461648382074801 0.690401570767024 0.437505284371634 0.21701445058421 NA NA NA 0.114335002046655 96.8327677577868 a2596 gain_cnaBRCA63 1053 MK-2206 AKT1, AKT2 5 37 1.38629436111989 0.693147180559945 2.24946213207767 1.27825971781339 0.971202414264271 1.06723436456796 1.67826371307349 0.596738776399293 0.910017936554576 0.578694758576205 0.217694815913463 NA NA NA 0.121303156109866 97.0646267680416 a2597 BRCA2_mut 263 FR-180204 ERK 6 43 2.99573227355399 NA 5.01074080602963 5.40632359867299 -0.395582792643368 0.675246257530836 0.732495844854881 0.544415028768531 0.585834853924094 0.540047831563794 0.217767342194849 NA NA NA 0.226678217673143 97.0646267680416 a2598 gain_cnaBRCA63 1194 SB-505124 TGFR1 (ALK5) 6 41 2.30258509299405 NA 4.82246018886748 4.32556575759298 0.4968944312745 1.18591238836774 0.86882620755447 0.546317923903151 0.418997588817175 0.571914644095664 0.217809171298462 NA NA NA 0.36236944123904 97.0646267680416 a2599 gain_cnaBRCA58_(CCND1) 346 THZ-2-102-1 CDK7 10 38 0.916290731874155 2.99573227355399 -0.448827909695396 -1.56840230420075 1.11957439450535 2.55544081632299 2.51312330831202 0.444018532667614 0.43811399870974 0.445491230295951 0.217869388522446 NA NA NA 0.23653576885703 97.0646267680416 a2600 gain_cnaBRCA27_(CLTC,PPM1D) 1001 AICAR AAPK1 (AMPK) agonist 10 35 7.60090245954208 NA 8.2152261912795 7.60227103981979 0.612955151459711 1.16773748276228 1.41546419859386 0.44828509130265 0.524908346702861 0.433041790861702 0.217984964971958 NA NA NA 0.181210736926703 97.0787657465501 a2601 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 16 27 1.6094379124341 NA 3.21798317754035 2.66053719359755 0.557445983942804 1.35758305425816 1.44350957682313 0.39460188916507 0.410616486552578 0.386174080791087 0.218120382614092 NA NA NA 0.212560045469875 97.0806775394635 a2602 gain_cnaBRCA15 257 NPK76-II-72-1 PLK3 22 27 2.32630161961136 NA 3.168826284247 3.73166208529335 -0.562835801046358 1.85362038474368 1.29790810806438 0.358335684185189 0.30364135271645 0.433648420523189 0.218347811800241 NA NA NA 0.23639503616035 97.0806775394635 a2603 BRCA1_mut 287 KIN001-244 PDPK1 (PDK1) 4 45 2.99573227355399 NA 4.03671240618955 3.42845214280542 0.608260263384127 1.27438804572979 0.906611257459134 0.650948623024572 0.477295958183444 0.670916292269341 0.218348141419773 NA NA NA 0.413981778857294 97.0806775394635 a2604 loss_cnaBRCA18 171 AKT inhibitor VIII AKT1, AKT2, AKT3 15 32 0.940007258491471 NA 1.55847612267989 2.04343178573357 -0.484955663053677 1.39456398478367 1.16617058875621 0.390546461458467 0.347747158499082 0.415853107366487 0.218454921537841 NA NA NA 0.254179119395956 97.0806775394635 a2605 gain_cnaBRCA8_(CHD4,WNK1) 291 KIN001-266 MAP3K8 (COT) 4 45 2.99573227355399 NA 3.07969932702926 3.84076197180022 -0.761062644770963 0.587428111937886 1.19890301608086 0.650778710826369 1.29558430947451 0.63479917438095 0.218466411744974 NA NA NA 0.0721577099310677 97.0806775394635 a2606 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 35 NVP-TAE684 ALK 4 10 0.693147180559945 NA 2.417428311652 1.51527913525919 0.902149176392813 1.46896884005066 1.05819917922543 0.768153417499998 0.614137721506536 0.85253248547514 0.218543269752539 NA NA NA 0.322045041125002 97.0806775394635 a2607 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 7 42 3.68887945411394 NA 2.94261206289809 3.54559970916568 -0.602987646267595 0.828198561076825 1.22815905259935 0.509003589615134 0.728071352217262 0.490968694153575 0.218649082836735 NA NA NA 0.127653656302135 97.0806775394635 a2608 loss_cnaBRCA18 1067 CCT007093 PPM1D 15 31 1.88706964903238 NA 4.34388824450143 3.96067556877956 0.383212675721869 0.785774033431877 1.05353609465347 0.392500284453013 0.487688138596516 0.363739484263153 0.218659993974368 NA NA NA 0.175660838763947 97.0806775394635 a2609 MLL3_mut 1054 PD-0332991 CDK4, CDK6 3 39 1.38629436111989 0.693147180559945 3.8910553746079 2.80535468937017 1.08570068523773 1.21204797922613 1.46176228579024 0.748605196152126 0.895757184406944 0.742734092808252 0.218760117334856 NA NA NA 0.255862757730321 97.0879033583863 a2610 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1203 QL-XII-61 BTK 11 12 2.30258509299405 NA 3.81710867978122 4.59930486650079 -0.782196186719565 1.8339410898276 1.05906575472652 0.528667139438705 0.426511075551012 0.73857188114023 0.219202256659387 NA NA NA 0.233909884782625 97.1625241264363 a2611 gain_cnaBRCA10_(MDM2,NUP107) 238 CAL-101 PI3Kdelta 5 44 2.99573227355399 2.32630161961136 4.22451892573298 4.7751511846251 -0.550632258892115 0.749016634661454 0.95277472377497 0.587554212378101 0.735140227080529 0.577924923019018 0.219312183722195 NA NA NA 0.185161139455343 97.1625241264363 a2612 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 184 BMS-754807 IGF1R 6 42 0.940007258491471 NA 0.83598576126045 1.73985226802551 -0.903866506765059 1.83334715682957 1.64162903658308 0.543339666442465 0.493014377226911 0.550591203385625 0.219456195498956 NA NA NA 0.294894156430667 97.1625241264363 a2613 loss_cnaBRCA42 136 Mitomycin C DNA crosslinker 3 45 2.77258872223978 NA -1.15401348667765 -0.0663247389861283 -1.08768874769153 1.45779783807189 1.46569082438416 0.742273064477527 0.746117684692224 0.742099718164328 0.219499105589948 NA NA NA 0.324101099334474 97.1625241264363 a2614 gain_cnaBRCA9_(KRAS) 260 NG-25 MAP3K7 (TAK1) 4 45 2.32630161961136 NA 3.96793431666639 3.14082421249834 0.827110104168051 1.17536858696542 1.28039291210424 0.649249529162246 0.703702747666154 0.64598147673963 0.219532963438432 NA NA NA 0.25773081803799 97.1625241264363 a2615 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 294 MPS-1-IN-1 MPS1 7 42 2.99573227355399 NA 5.26238216457162 4.67220695935128 0.590175205220335 1.27011739124547 1.14544186747638 0.50785106941043 0.464661935414972 0.515238024711457 0.219676978009154 NA NA NA 0.283114703939955 97.1625241264363 a2616 gain_cnaBRCA27_(CLTC,PPM1D) 275 I-BET BRD2, BRD3, BRD4 9 40 2.99573227355399 NA 3.5342367231324 4.15249953497664 -0.61826281184424 1.36976937128451 1.34274058308902 0.458863151112406 0.451362707332594 0.460448443750696 0.219755966781871 NA NA NA 0.243593245328458 97.1625241264363 a2617 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 274 PXD101, Belinostat HDAC 15 33 2.99573227355399 NA 0.276781234507486 0.850922487537859 -0.574141253030372 1.22644101508498 1.58134475432576 0.387317484812668 0.468136050546704 0.36307152596536 0.219876004848988 NA NA NA 0.180043306195643 97.1625241264363 a2618 loss_cnaBRCA20 1527 GDC0941 (rescreen) PI3K 3 42 1.38629436111989 NA 1.7758005628319 0.923859789830165 0.851940773001738 0.711803314374122 1.16205771888511 0.744021687936761 1.19687665932103 0.733131202655835 0.219879184805166 NA NA NA 0.159156537808229 97.1625241264363 a2619 loss_cnaBRCA28_(GPS2) 206 Ruxolitinib JAK1, JAK2, TYK2 4 45 1.65632149833295 0.0237165266173161 3.98438080944621 4.40456086503177 -0.420180055585562 1.52187368885515 0.538714172647954 0.64871894236572 0.276093908885204 0.779968445085158 0.219903929568189 NA NA NA 0.620368179346677 97.1625241264363 a2620 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 5 42 2.77258872223978 NA 4.4769352107662 5.07446889626793 -0.597533685501729 1.21038401576431 0.994342740356544 0.588465758528431 0.493672815998325 0.600933321328891 0.219980901357599 NA NA NA 0.340066777905008 97.1625241264363 a2621 ARID1A_mut 1025 SB 216763 GSK3A, GSK3B 5 34 2.30258509299405 NA 4.48398037358348 4.94874676848864 -0.464766394905163 0.925467115244462 0.75812529785771 0.597421719239483 0.502196552691551 0.613046941209437 0.220122657101692 NA NA NA 0.334680883833476 97.1625241264363 a2622 gain_cnaBRCA16 200 LAQ824 HDAC 16 32 0.0237165266173161 NA -3.03917384649516 -2.5071141915799 -0.532059654915258 0.947311814613516 1.570555568908 0.380534669909117 0.561652084041966 0.338771620341455 0.220231759194569 NA NA NA 0.15191327098086 97.1625241264363 a2623 gain_cnaBRCA12_(TERT) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 10 36 0 NA -0.0565827783152672 0.850381235348301 -0.906964013663569 1.72878260606785 2.1131360476838 0.444499372623948 0.524625832351747 0.429202849791753 0.220270931274997 NA NA NA 0.180814360244134 97.1625241264363 a2624 gain_cnaBRCA12_(TERT) 1495 AZD-2281 PARP1, PARP2 10 35 2.30258509299405 NA 3.61047271082525 4.10961089299249 -0.499138182167238 1.25227757290098 1.08109955300097 0.446018999190319 0.398584301889997 0.461694929742321 0.220279411411353 NA NA NA 0.272938814105862 97.1625241264363 a2625 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 302 PI-103 PI3Ka, PRKDC (DNAPK) 5 43 2.32630161961136 NA 0.162407293045666 1.24076174851626 -1.07835445547059 0.894244300691461 1.9030942837499 0.586862866662578 1.20588350927903 0.566632176176674 0.220517469715802 NA NA NA 0.0566899918046325 97.1625241264363 a2626 loss_cnaBRCA18 1017 Olaparib PARP1, PARP2 14 31 1.6094379124341 NA 4.31699773649702 3.96440148680136 0.352596249695659 0.621211266237873 0.97220211670469 0.400239964974292 0.567594744105371 0.362677928423768 0.220615678776723 NA NA NA 0.151651345397571 97.1625241264363 a2627 gain_cnaBRCA31 206 Ruxolitinib JAK1, JAK2, TYK2 16 33 1.65632149833295 0.0237165266173161 4.53522652093892 4.2902769039149 0.244949617024026 0.603212188795257 0.667591668553038 0.37816004964996 0.406075377079568 0.36691532947818 0.220635983892261 NA NA NA 0.207270845285791 97.1625241264363 a2628 gain_cnaBRCA19 207 AS601245 JNK 4 44 2.07944154167984 NA 1.51019532816257 2.33492847542212 -0.824733147259553 1.04656484718596 1.28631608484383 0.648345411706696 0.78803826583429 0.641159009808759 0.220719342270486 NA NA NA 0.215727721070945 97.1625241264363 a2629 gain_cnaBRCA13_(FGFR1,WHSC1L1) 152 CP466722 ATM 11 38 2.77258872223978 NA 2.38343414030305 2.83050449289082 -0.447070352587772 0.728459569200828 1.12370155807827 0.424924694131067 0.613720200117956 0.397855061580891 0.220732731058001 NA NA NA 0.129711074539011 97.1625241264363 a2630 gain_cnaBRCA64_(SDHC) 260 NG-25 MAP3K7 (TAK1) 8 41 2.32630161961136 NA 3.71962311968506 3.10858150906367 0.611041610621385 1.70684574444593 1.18214674871131 0.479600852733778 0.357994629924651 0.516891503772691 0.220819808849424 NA NA NA 0.360091696480415 97.1625241264363 a2631 BRCA2_mut 175 PAC-1 CASP3 agonist 6 42 0.940007258491471 NA 1.82712961107725 2.48341782761109 -0.656288216533843 0.574283846572906 1.267809566138 0.541577811758109 1.14279414343675 0.51765520158759 0.220930211495446 NA NA NA 0.0501537873782403 97.1625241264363 a2632 POLR2B_mut 1194 SB-505124 TGFR1 (ALK5) 3 44 2.30258509299405 NA 3.75817482308825 4.43200983466482 -0.673835011576574 0.805790592168459 0.914289598086808 0.740687839693005 0.836240852307819 0.737003913187467 0.220930392080911 NA NA NA 0.281201816528824 97.1625241264363 a2633 loss_cnaBRCA36_(FAT1,IRF2) 300 CX-5461 RNA Pol I 9 40 2.32630161961136 NA 3.27980379803334 4.05469162964156 -0.774887831608222 2.3384894855551 1.52748857410715 0.457649738094785 0.331362546804132 0.507295337420879 0.220958326232319 NA NA NA 0.365650318294329 97.1625241264363 a2634 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1264 SGC0946 Q8TEK3 (DOT1L) 9 37 -0.693147180559945 NA 2.17385179318175 1.89643682092258 0.27741497225917 0.4537295194523 0.629448347756136 0.461334934925895 0.611410455713879 0.44072714345522 0.221089995656774 NA NA NA 0.149058163533933 97.1625241264363 a2635 gain_cnaBRCA62 153 Midostaurin KIT 9 38 -0.669430653942629 NA 1.14843026221641 0.485178386155324 0.663251876061082 1.32300558823585 1.46692088619446 0.459829733947583 0.501322051818006 0.452138818325584 0.221256730634909 NA NA NA 0.208286550599591 97.1625241264363 a2636 gain_cnaBRCA9_(KRAS) 265 Tubastatin A HDAC6 4 45 2.99573227355399 NA 4.08234259423619 4.74592988434622 -0.663587290110024 1.21990928041102 1.01152338212187 0.646714613590372 0.543964457657409 0.656027633012314 0.221309469648039 NA NA NA 0.360528769687162 97.1625241264363 a2637 loss_cnaBRCA28_(GPS2) 152 CP466722 ATM 4 45 2.77258872223978 NA 2.10545092142649 2.7856698352773 -0.680218913850813 0.862442688866119 1.06387506675698 0.646491151532227 0.788712018354656 0.639378565308735 0.221466583763514 NA NA NA 0.215325390767627 97.1625241264363 a2638 gain_cnaBRCA63 1371 PLX4720 (rescreen) BRAF 6 41 2.30258509299405 NA 4.25917166809001 4.77270475973259 -0.51353309164258 2.41071504948616 0.533024732726596 0.541831079868432 0.213021066820834 0.963432013774841 0.221548204805356 NA NA NA 0.624997685055523 97.1625241264363 a2639 gain_cnaBRCA14_(RAD21) 200 LAQ824 HDAC 21 27 0.0237165266173161 NA -2.96799667857819 -2.46394464534583 -0.504052033232353 1.01257173251571 1.63424141004707 0.360466415761258 0.497793901455307 0.308431808258875 0.221667659887948 NA NA NA 0.19652684270333 97.1625241264363 a2640 loss_cnaBRCA18 304 SB52334 ALK5 16 33 2.99573227355399 NA 3.98121608733086 4.457370855937 -0.476154768606136 1.16312676224028 1.30635048798115 0.377179946117604 0.409374785332101 0.364492357133031 0.221815565031319 NA NA NA 0.206016931296861 97.1625241264363 a2641 gain_cnaBRCA30_(CRNKL1,FOXA2) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 5 41 2.30258509299405 NA 1.92901231539113 1.35026791527234 0.578744400118787 0.913099318445711 0.992985749214537 0.586967317985048 0.633824150809721 0.582832533675917 0.221871818040461 NA NA NA 0.240164074203418 97.1625241264363 a2642 BRCA1_mut 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 4 44 0.246860077931526 2.32630161961136 0.706372631764951 -0.353254098920497 1.05962673068545 2.22137908827579 1.59024947879007 0.646572890654252 0.47701301244711 0.666327356064694 0.221963434779502 NA NA NA 0.41437171854981 97.1625241264363 a2643 gain_cnaBRCA63 1022 AZD7762 CHEK1, CHEK2 6 39 0.693147180559945 NA 1.6617278417026 0.788292661605466 0.873435180097133 2.12135703963125 1.52700264721678 0.543368693261858 0.41173417005228 0.57199323242112 0.22203999856794 NA NA NA 0.370314373103278 97.1625241264363 a2644 loss_cnaBRCA36_(FAT1,IRF2) 344 THZ-2-49 CDK9 9 40 2.99573227355399 NA 2.3297349104692 1.66277151447912 0.666963395990083 1.64605076934993 1.42027912883691 0.456457202461565 0.405190051491234 0.469600223257714 0.222144734545685 NA NA NA 0.284880351592974 97.1625241264363 a2645 gain_cnaBRCA15 255 CP724714 ERBB2 22 26 2.32630161961136 NA 3.48197730960906 4.07470046458234 -0.592723154973278 2.02021658831677 1.26694661230913 0.35836782747323 0.293395845970718 0.46783593658535 0.222326648436655 NA NA NA 0.241475573204939 97.1625241264363 a2646 gain_cnaBRCA14_(RAD21) 60 BI-2536 PLK1, PLK2, PLK3 6 6 -1.36257783450257 NA -2.06399840453793 -0.931713478739629 -1.1322849257983 1.45204902258387 1.56105059865624 0.75108352622277 0.779784227796548 0.725335185658284 0.222464365832927 NA NA NA 0.222612454302227 97.1625241264363 a2647 gain_cnaBRCA10_(MDM2,NUP107) 300 CX-5461 RNA Pol I 5 44 2.32630161961136 NA 4.79958431158907 3.81154495022766 0.988039361361404 0.913946212209098 1.74829583190012 0.583475726651302 1.0810694854495 0.565144264107501 0.222477107754566 NA NA NA 0.0771556138685146 97.1625241264363 a2648 POLR2B_mut 1042 BIRB 0796 p38, JNK2 3 40 2.30258509299405 NA 4.99751017718831 4.3192769579152 0.678233219273106 0.536161650655249 0.929990937699193 0.741463642854615 1.26497898244723 0.729290137978185 0.222522546860472 NA NA NA 0.142290097700242 97.1625241264363 a2649 PIK3CA_mut 5 Sunitinib PDGFRA, PDGFRB, KDR, KIT, FLT3 4 8 2.07944154167984 NA 3.96427136890376 2.90096992741789 1.06330144148587 1.34558513726456 1.33059920227843 0.796413280617671 0.790214912485921 0.799114744443813 0.222588680318761 NA NA NA 0.242603743665882 97.1625241264363 a2650 PTEN_mut 1007 Docetaxel Microtubules 7 38 -4.38202663467388 NA -5.24425795135262 -4.46625733787509 -0.778000613477525 1.38419624261333 1.55116672941499 0.50884183287955 0.562059475041399 0.501558342326581 0.222750438715416 NA NA NA 0.212988243391987 97.1625241264363 a2651 loss_cnaBRCA17 303 PIK-93 PI4K, PI3K 11 38 2.99573227355399 NA 2.32910053710795 2.9253875493559 -0.596287012247954 1.29889182646551 1.43828707851264 0.422963597758945 0.459073650398238 0.414581359421366 0.222836678461222 NA NA NA 0.207545500519825 97.1625241264363 a2652 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1031 Elesclomol HSP70 14 30 -1.6094379124341 NA -2.49480470511228 -3.20287377445136 0.708069069339084 2.00599258731093 1.65046766414053 0.400453832304712 0.352976912187031 0.429011173452953 0.222874310381507 NA NA NA 0.262215209689456 97.1625241264363 a2653 CDH1_mut 303 PIK-93 PI4K, PI3K 4 45 2.99573227355399 NA 1.95743949508053 2.86566832896422 -0.908228833883683 1.04818299982505 1.4311381019622 0.64422273645794 0.866479263673684 0.634619980167135 0.223066156755235 NA NA NA 0.182545988089635 97.1625241264363 a2654 gain_cnaBRCA10_(MDM2,NUP107) 1529 MLN4924 NEDD8-activating enzyme 3 34 0 NA -0.783364509566467 0.470913488401159 -1.25427799796763 1.95624575518488 1.6615869038011 0.746675158341615 0.641165863053382 0.754867527601653 0.22331944187014 NA NA NA 0.382879362470837 97.1625241264363 a2655 NF1_mut 179 5-Fluorouracil DNA antimetabolite 5 44 3.46573590279973 NA 4.88042188406058 3.94614200668957 0.934279877371011 0.974110787490758 1.65093691063702 0.582291328845721 0.959110492737332 0.56590889170351 0.223402500063345 NA NA NA 0.105071019631763 97.1625241264363 a2656 MACF1_mut 1036 PLX4720 BRAF 3 40 2.30258509299405 NA 5.41613813309626 4.53515149521779 0.88098663787847 0.405972852194767 1.21721830784888 0.739988993294772 2.17006293183322 0.723770446268907 0.2234271139961 NA NA NA 0.0301773642690404 97.1625241264363 a2657 gain_cnaBRCA47_(EGFR) 157 JNK-9L JNK 7 40 1.63315443905142 NA -0.394560797746163 0.134665189551146 -0.529225987297308 0.607573288787547 1.09842575122769 0.50577410175233 0.871048805245231 0.4818040606803 0.223429119251742 NA NA NA 0.0871825372140113 97.1625241264363 a2658 loss_cnaBRCA24 274 PXD101, Belinostat HDAC 3 45 2.99573227355399 NA -0.351196961070949 0.739683366434988 -1.09088032750594 0.622887144011258 1.51023426315645 0.735720375769482 1.75132901360093 0.722325240606022 0.22352937912811 NA NA NA 0.0643054223877943 97.1625241264363 a2659 PIK3CA_mut 294 MPS-1-IN-1 MPS1 17 32 2.99573227355399 NA 5.03754338711855 4.60722280824187 0.430320578876683 1.15119409915199 1.16816308441678 0.370195556572605 0.373803669766611 0.368373718205216 0.223529472084209 NA NA NA 0.223991746945444 97.1625241264363 a2660 gain_cnaBRCA63 1052 RO-3306 CDK1 5 38 1.6094379124341 NA 4.14364903813804 3.44436077150961 0.699288266628429 0.96059807428064 1.2116593116044 0.587883950477079 0.727971755671177 0.577132746747496 0.22358150179013 NA NA NA 0.190784385065919 97.1625241264363 a2661 gain_cnaBRCA16 299 OSI-027 MTORC1/2 16 32 2.99573227355399 NA 0.773759880499708 1.51657440519581 -0.742814524696102 1.7027764955531 2.08384567044337 0.377502126556861 0.436237243487919 0.356463309750792 0.223870655905458 NA NA NA 0.195314085078286 97.1625241264363 a2662 CDH1_mut 1175 AG-014699 PARP1, PARP2 4 39 1.6094379124341 NA 4.45913548621993 3.8002819472538 0.65885353896613 0.883915931168258 1.02620207053585 0.64818029100957 0.745380319252006 0.642030997483856 0.224011146644509 NA NA NA 0.236910555645434 97.1625241264363 a2663 gain_cnaBRCA62 164 JQ12 HDAC 9 38 1.63315443905142 NA 2.17885128114763 1.43554861897705 0.74330266217058 1.41786552939667 1.66870141520312 0.456872345647146 0.524240590351944 0.445437784973713 0.224192388913845 NA NA NA 0.194197691959539 97.1625241264363 a2664 ARID1A_mut 1069 EHT 1864 Rac GTPases 5 41 2.30258509299405 NA 3.11858397164807 3.61542629286935 -0.496842321221272 0.105188418864241 0.891925286396562 0.583827623774279 4.72335573236924 0.557044775833801 0.224312134767592 NA NA NA 0.00153299690634322 97.1625241264363 a2665 POLR2B_mut 170 Shikonin unknown 3 44 2.77258872223978 NA -0.805721346959416 0.0587895539791063 -0.864510900938522 1.65474265323288 1.14910038637654 0.735004380845674 0.522444320420172 0.752337142331474 0.224434854126242 NA NA NA 0.462100860798154 97.1625241264363 a2666 loss_cnaBRCA17 309 Y-39983 ROCK 11 38 2.99573227355399 NA 4.5839661793773 5.03659045953167 -0.452624280154371 1.10920686918056 1.06459222844464 0.421343763719438 0.408061194652313 0.425162111896733 0.224585647435537 NA NA NA 0.246938635090414 97.1625241264363 a2667 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 37 1.6094379124341 NA 3.3087672876541 2.44711017228357 0.861657115370527 0.847325608145358 1.66486365937779 0.542652329225313 1.01691381339995 0.517554161577745 0.22459786389359 NA NA NA 0.0734530273186868 97.1625241264363 a2668 PIK3CA_mut 1377 Afatinib (rescreen) ERBB2, EGFR 16 31 2.30258509299405 NA 2.34199144367672 3.08891041971934 -0.746918976042619 2.07616988918504 1.91563730565844 0.379030907323126 0.359758119956074 0.389906259309296 0.224604311877878 NA NA NA 0.240286994515428 97.1625241264363 a2669 loss_cnaBRCA28_(GPS2) 163 JQ1 BRD4 4 43 0.940007258491471 NA -0.535210023655594 0.395091327676384 -0.930301351331979 1.50420840061206 1.44110788041256 0.643628868664642 0.618465733174634 0.645545946959678 0.224620820166847 NA NA NA 0.308776887467598 97.1625241264363 a2670 gain_cnaBRCA31 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 13 30 1.6094379124341 NA 3.27162157822659 2.69303848502779 0.578583093198809 1.29813063584856 1.45846173780236 0.409349912377057 0.445704829098807 0.396707762845141 0.224672444305427 NA NA NA 0.207906271137455 97.1625241264363 a2671 loss_cnaBRCA22_(SYNCRIP,ZNF292) 194 AUY922 HSP90 18 29 -1.36257783450257 NA -2.00346204917857 -2.63599295279283 0.632530903614257 1.90818416772948 1.58169363135165 0.36938989053683 0.331483152575832 0.399907346831588 0.224704267559246 NA NA NA 0.247906693891361 97.1625241264363 a2672 loss_cnaBRCA18 204 Tipifarnib Farnesyl-transferase (FNTA) 16 32 2.77258872223978 NA 1.2429211438668 1.80850421931859 -0.565583075451787 1.08308214259109 1.66604450879383 0.376795470973671 0.522197766181175 0.339476570083505 0.224724951008344 NA NA NA 0.164711595072306 97.1625241264363 a2673 BRCA2_mut 341 EX-527 SIRT1 6 43 2.99573227355399 NA 5.33639703678437 5.68436108093282 -0.34796404414845 0.795950458315738 0.629284180411584 0.536111107309883 0.437167967570188 0.552952155766674 0.224753806205281 NA NA NA 0.344643443767289 97.1625241264363 a2674 loss_cnaBRCA38 152 CP466722 ATM 4 45 2.77258872223978 NA 2.10982036793457 2.78528144003214 -0.67546107209757 1.05104136649003 1.05250328799523 0.641823101200337 0.642658884448368 0.641766234653917 0.224767529968762 NA NA NA 0.293264410791803 97.1625241264363 a2675 loss_cnaBRCA23 219 AT-7519 CDK9 3 46 2.32630161961136 NA 0.435783494555405 1.752623351767 -1.3168398572116 1.77616933575332 1.79776861058864 0.732858253588081 0.741393194164731 0.732485732288112 0.224864278858567 NA NA NA 0.326523847655599 97.1625241264363 a2676 gain_cnaBRCA61_(NOTCH2) 156 AZD6482 PI3Kbeta 3 44 1.63315443905142 NA 1.05729667570896 2.121219787828 -1.06392311211904 2.1613342015582 1.40710596102871 0.734252612846862 0.492252938648735 0.756107316425001 0.224901458216999 NA NA NA 0.484814965684872 97.1625241264363 a2677 TP53_mut 258 STF-62247 stimulates autophagy 38 11 2.32630161961136 NA 4.7209331658129 4.31962200571214 0.401311160100762 0.913597679045565 1.0874562330582 0.420993371888159 0.439264644936501 0.369036608463932 0.224965301333775 NA NA NA 0.283057196257868 97.1625241264363 a2678 gain_cnaBRCA47_(EGFR) 135 Gemcitabine DNA replication 6 41 0.0237165266173161 NA -1.56013510035078 -0.0871879194006357 -1.47294718095015 2.18429926507704 2.80076428370706 0.537743067521102 0.674333963527748 0.5259090133071 0.224996075309543 NA NA NA 0.178113046321729 97.1625241264363 a2679 loss_cnaBRCA57 287 KIN001-244 PDPK1 (PDK1) 5 44 2.99573227355399 NA 3.96515559904993 3.4227595012671 0.542396097782825 0.395428078058841 0.969901928742187 0.580191760185106 1.37166814366206 0.559227775210457 0.225049911505681 NA NA NA 0.0378232815149075 97.1625241264363 a2680 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 164 JQ12 HDAC 9 38 1.63315443905142 NA 2.17774754383359 1.43581003044617 0.741937513387425 1.92038121443915 1.55635980628739 0.456005013644842 0.386349078927076 0.476713360490383 0.225058782262061 NA NA NA 0.304804349350032 97.1625241264363 a2681 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 29 AZ628 BRAF 3 11 1.38629436111989 NA 3.78415984078098 2.1320678611065 1.65209197967448 0.353693642334096 2.16784668819442 0.83261318425355 4.67096883272199 0.762088937687055 0.225312041960533 NA NA NA 0.0335694354707509 97.1625241264363 a2682 gain_cnaBRCA14_(RAD21) 1054 PD-0332991 CDK4, CDK6 19 23 1.38629436111989 0.693147180559945 3.18627178277192 2.63229717985191 0.553974602920013 1.24275643242075 1.60149294461308 0.381767531166646 0.445762812782976 0.345911360261316 0.225347556487732 NA NA NA 0.214407354929527 97.1625241264363 a2683 POLR2B_mut 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 3 42 2.30258509299405 NA 0.616026769762417 1.41884524715711 -0.802818477394697 0.32271298183264 1.11623352632402 0.735057020267074 2.48771670986276 0.719220896400183 0.225389586964694 NA NA NA 0.0169800003623257 97.1625241264363 a2684 loss_cnaBRCA20 1529 MLN4924 NEDD8-activating enzyme 3 34 0 NA 1.51653981966103 0.267980753469321 1.24855906619171 1.73465279075102 1.6767930933548 0.743122225995373 0.719774627434893 0.744611288739086 0.225483305577272 NA NA NA 0.337940591185691 97.1625241264363 a2685 ASH1L_mut 1375 Temozolomide DNA akylating agent 3 43 3.40119738166216 NA 5.42542127260834 5.9332448653799 -0.507823592771568 0.199946152348628 0.706742411562695 0.734052886844895 2.53980177566069 0.718541273968131 0.225508218324212 NA NA NA 0.0154604801810055 97.1625241264363 a2686 loss_cnaBRCA7_(FAS,PTEN) 276 CAY10603 HDAC6 4 45 2.99573227355399 NA 1.75427023816657 1.12409703492412 0.630173203242445 1.07223052817122 0.977156227486549 0.640745870120693 0.587721750766841 0.644905272582034 0.225534405951069 NA NA NA 0.329122258429086 97.1625241264363 a2687 gain_cnaBRCA14_(RAD21) 1033 Vismodegib SMO 20 25 2.30258509299405 NA 4.91861293461263 4.63270387773728 0.285909056875345 0.833684123728852 0.725624802482784 0.368804740406507 0.342946505442071 0.394017756693382 0.225625644416952 NA NA NA 0.23367826557128 97.1625241264363 a2688 gain_cnaBRCA62 1050 ZM-447439 AURKB 7 32 1.38629436111989 0.693147180559945 3.43761098808285 2.767680070757 0.66993091732585 1.84581886399062 1.1691712008987 0.51414846130831 0.362945102791654 0.572996424142932 0.225648576979742 NA NA NA 0.387461679410998 97.1625241264363 a2689 gain_cnaBRCA63 222 BX-912 PDPK1 (PDK1) 7 42 2.32630161961136 NA 4.52779818901797 3.77644454501178 0.751353644006188 2.07841166874869 1.39431480896716 0.501192955130728 0.361503765256736 0.538869442663922 0.225685269374955 NA NA NA 0.387276316803467 97.1625241264363 a2690 loss_cnaBRCA33 119 Lapatinib ERBB2, EGFR 4 9 0.693147180559945 NA 2.59916063244238 0.928041127868473 1.67111950457391 0.846535358123031 2.48736015645612 0.771236178955958 1.97406935048664 0.671844606112389 0.225725183435628 NA NA NA 0.100725327293155 97.1625241264363 a2691 BRCA2_mut 226 GSK1070916 AURKB 6 43 0.940007258491471 2.32630161961136 1.49760375200311 2.53041430788918 -1.03281055588607 1.97246004098291 1.92671010145649 0.534683812420412 0.523615451987257 0.536048757467624 0.225971123232705 NA NA NA 0.270860826594889 97.208235110675 a2692 NF1_mut 235 QL-XII-47 BTK, BMX 5 44 2.32630161961136 NA 0.932658126961874 1.79619065935003 -0.863532532388152 1.40539070971118 1.49942490073755 0.578909875228967 0.614443034539211 0.575909158213519 0.226060127228393 NA NA NA 0.251590926677919 97.208235110675 a2693 gain_cnaBRCA47_(EGFR) 211 TL-2-105 CRAF 7 42 2.32630161961136 1.63315443905142 4.37062662793828 3.83037492128325 0.540251706655033 0.671967717777441 1.12658531821267 0.500573688166667 0.803984614680503 0.47954797379407 0.226250194172491 NA NA NA 0.103585550357927 97.208235110675 a2694 gain_cnaBRCA15 1017 Olaparib PARP1, PARP2 21 24 1.6094379124341 NA 4.24645068794562 3.92328958145594 0.323161106489685 0.914792480886866 0.851202065359368 0.366666067940132 0.353261655776171 0.37965263436391 0.226461451835238 NA NA NA 0.22899066147102 97.208235110675 a2695 gain_cnaBRCA16 1039 SL 0101-1 RSK, AURKB, PIM3 14 29 2.30258509299405 NA 4.39145145900769 4.77307927646871 -0.381627817461015 1.2281094139438 0.797153780697675 0.399573005980379 0.310744151236088 0.478738013544905 0.226527390491927 NA NA NA 0.302855790580896 97.208235110675 a2696 PTEN_mut 1024 CEP-701 FLT3, JAK2, NTRK1, RET 7 38 0.693147180559945 NA 0.019432678740501 0.737225598811138 -0.717792920070637 1.40053390314317 1.42625379766484 0.504531178640315 0.512513776681677 0.503271522393739 0.226626663951041 NA NA NA 0.247386924115308 97.208235110675 a2697 loss_cnaBRCA17 326 GSK690693 AKT 10 38 2.32630161961136 NA 2.27983973749641 3.11319364867068 -0.833353911174264 1.4604638190546 2.00821115188994 0.435530791871355 0.570609076583438 0.414973251388426 0.226649073883873 NA NA NA 0.156691952053872 97.208235110675 a2698 NF1_mut 1259 BMN-673 PARP1 5 41 2.30258509299405 NA 2.50697379293128 3.40292392434602 -0.895950131414741 1.00348678537181 1.58709951112268 0.580582662474714 0.89283700042226 0.564520450756716 0.226855064268121 NA NA NA 0.125609175806578 97.208235110675 a2699 gain_cnaBRCA47_(EGFR) 1033 Vismodegib SMO 7 38 2.30258509299405 NA 4.4296403270944 4.82058877226378 -0.39094844516938 0.753148312500797 0.778836998821563 0.504252050504297 0.51908560197294 0.501964397891874 0.226879368150533 NA NA NA 0.242623095608376 97.208235110675 a2700 gain_cnaBRCA15 1016 Temsirolimus MTOR 20 24 -1.6094379124341 NA -1.45029295846995 -2.00148095965307 0.551188001183123 1.24167401416405 1.65862274116447 0.371275494007723 0.443907172813155 0.332316679075647 0.226923309954527 NA NA NA 0.215108349552019 97.208235110675 a2701 loss_cnaBRCA20 1033 Vismodegib SMO 3 42 2.30258509299405 NA 4.22999657536909 4.79761585498994 -0.567619279620851 0.588786982166261 0.783287277946708 0.732106423688585 0.964048623378986 0.724662962877165 0.227225409624384 NA NA NA 0.229814181242271 97.208235110675 a2702 gain_cnaBRCA13_(FGFR1,WHSC1L1) 157 JNK-9L JNK 10 37 1.63315443905142 NA 0.415302747073614 -0.0413066344030664 0.45660938147668 1.3249634325633 0.96461544733012 0.43625480893217 0.344620364800042 0.47335897713487 0.227310917405066 NA NA NA 0.3287040401179 97.208235110675 a2703 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 9 38 2.99573227355399 NA 4.36687807004587 3.72469021797024 0.642187852075635 1.43257697098808 1.41152817647205 0.453749027972049 0.448274588438136 0.454959286523566 0.227323898129309 NA NA NA 0.2486747145836 97.208235110675 a2704 gain_cnaBRCA19 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 4 43 2.32630161961136 NA 0.527718617402063 1.49965419781479 -0.971935580412722 1.65748876118342 1.50916837346184 0.639638813997193 0.586390449923036 0.64402063911744 0.227460498480831 NA NA NA 0.330304478221636 97.208235110675 a2705 BRCA1_mut 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 4 39 -1.38629436111989 0.693147180559945 -1.67008021387126 -2.27696560519864 0.606885391327377 0.646240089109519 0.962995216756458 0.643274745870906 0.939102048224259 0.630206028822736 0.227473532939459 NA NA NA 0.157255747341401 97.208235110675 a2706 POLR2B_mut 133 Doxorubicin DNA intercalating 3 45 0.0237165266173161 NA -2.2746312994923 -0.947712562470053 -1.32691873702225 1.40869014643317 1.8362083717456 0.729192271436661 0.941952167680051 0.722640609551741 0.227598634611845 NA NA NA 0.238157360283852 97.208235110675 a2707 loss_cnaBRCA18 17 Cyclopamine SMO 5 8 2.77258872223978 NA 4.33989780980584 4.91797938228095 -0.578081572475112 1.10550781607428 0.539627943637558 0.728473156468128 0.522910434525837 1.07125952110327 0.227618513111903 NA NA NA 0.323161470394902 97.208235110675 a2708 TP53_mut 1199 Tamoxifen ER 37 10 1.6094379124341 NA 3.95680563292006 3.54491920297448 0.411886429945575 0.897338226481954 1.11513860442005 0.435894158770025 0.459009120296134 0.369358955302048 0.227689166080416 NA NA NA 0.30187260968418 97.208235110675 a2709 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 274 PXD101, Belinostat HDAC 6 42 2.99573227355399 NA -0.0207491574314491 0.770396560736913 -0.791145718168362 0.704343015073055 1.55164670977965 0.533410355021688 1.12323924740888 0.509874904630008 0.227859145075135 NA NA NA 0.0535503125222422 97.208235110675 a2710 BRCA2_mut 1161 ZG-10 IRAK1 3 23 2.30258509299405 NA 1.04879578486418 2.09627339840228 -1.0474776135381 0.165175410951041 1.43948764978487 0.759576158521785 6.34160743119675 0.727673914878424 0.227909923565194 NA NA NA 0.00282914216518256 97.208235110675 a2711 gain_cnaBRCA48 1022 AZD7762 CHEK1, CHEK2 5 40 0.693147180559945 NA 0.0754017292502825 1.00841930516443 -0.933017575914151 1.19416407257335 1.64473295659414 0.5801793106362 0.781314391667766 0.56727602628345 0.22794340455654 NA NA NA 0.166597270213581 97.208235110675 a2712 gain_cnaBRCA30_(CRNKL1,FOXA2) 196 Phenformin AAPK1 (AMPK) agonist 5 43 8.29404964010203 NA 8.13115785813316 7.09397299404083 1.03718486409233 3.11120882845457 1.61632498427621 0.577369879832556 0.333370378293613 0.641693269721241 0.227952268080342 NA NA NA 0.501349771860689 97.208235110675 a2713 loss_cnaBRCA29_(MAP2K4) 1114 Cetuximab EGFR 7 38 4.18661983833127 NA 6.65210632447632 6.21451534762248 0.437590976853842 0.85483115983252 0.872262216563601 0.503064322607501 0.51190339966032 0.501673657925701 0.227956984503376 NA NA NA 0.248005850646612 97.208235110675 a2714 loss_cnaBRCA17 184 BMS-754807 IGF1R 11 37 0.940007258491471 NA 1.0884824285344 1.78692981380421 -0.698447385269809 1.56523639417345 1.69108509407501 0.419604784956161 0.44622485643048 0.413017291511192 0.227989913692311 NA NA NA 0.218871126752755 97.208235110675 a2715 TP53_mut 136 Mitomycin C DNA crosslinker 38 10 2.77258872223978 NA -0.00166893830028389 -0.638323405899795 0.636654467599511 1.24660271640328 2.14458424813199 0.434212628551543 0.510711599792111 0.296866149303325 0.228035646297216 NA NA NA 0.388204684186679 97.208235110675 a2716 gain_cnaBRCA62 1166 QL-VIII-58 MTOR, ATR 4 22 2.30258509299405 NA -0.891274020024718 -1.63316399232017 0.741889972295456 1.76223880770922 0.973840062839343 0.67222558031593 0.420992869439675 0.761819112403726 0.228158675564142 NA NA NA 0.4668811191765 97.208235110675 a2717 gain_cnaBRCA63 1166 QL-VIII-58 MTOR, ATR 4 22 2.30258509299405 NA -0.891274020024718 -1.63316399232017 0.741889972295456 1.76223880770922 0.973840062839343 0.67222558031593 0.420992869439675 0.761819112403726 0.228158675564142 NA NA NA 0.4668811191765 97.208235110675 a2718 BRCA2_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 5 38 2.30258509299405 NA 3.22595727247884 3.88567871951326 -0.659721447034421 1.87890779270811 1.02163255494576 0.581681622603487 0.351119650253593 0.645752177571756 0.228416731318646 NA NA NA 0.481129715381561 97.208235110675 a2719 ASH1L_mut 1059 AZD8055 MTORC1/2 3 40 0.693147180559945 NA -0.5490420846689 0.181391195023141 -0.730433279692041 0.937566194482129 1.0012751340731 0.731705191032509 0.779073823257354 0.729503065476817 0.228559223989252 NA NA NA 0.307608416545428 97.208235110675 a2720 loss_cnaBRCA20 346 THZ-2-102-1 CDK7 3 45 0.916290731874155 2.99573227355399 -3.05632829569904 -1.22041292821078 -1.83591536748826 1.47264848682184 2.56090647437448 0.727565105800629 1.24667589307099 0.716900591981477 0.228621357857701 NA NA NA 0.147199869851322 97.208235110675 a2721 loss_cnaBRCA34 1053 MK-2206 AKT1, AKT2 5 37 1.38629436111989 0.693147180559945 2.22979853426866 1.28091696076056 0.948881573508105 2.25108880751226 1.54444901661473 0.582505412944196 0.421521163599379 0.614381933816084 0.228660313589001 NA NA NA 0.406836114664615 97.208235110675 a2722 loss_cnaBRCA23 1529 MLN4924 NEDD8-activating enzyme 3 34 0 NA 1.50866114585353 0.268675930569982 1.23998521528355 1.15106948293557 1.70747816488292 0.737799625614531 1.07724619031791 0.72620853419146 0.228754127777466 NA NA NA 0.191213249006343 97.208235110675 a2723 gain_cnaBRCA14_(RAD21) 55 A-770041 SRC family 6 6 1.63315443905142 NA 2.28152021043664 3.12835752945585 -0.846837319019203 1.40507260869858 0.802449102863599 0.74014604975819 0.602700041105756 1.05531592719987 0.228775962916928 NA NA NA 0.235980565256994 97.208235110675 a2724 gain_cnaBRCA30_(CRNKL1,FOXA2) 1019 Bosutinib SRC, ABL, TEC 5 40 0.693147180559945 NA 3.13915308165225 2.6030292192672 0.536123862385055 1.06649184000954 0.910103504486989 0.57911355222232 0.502698513267819 0.589080098847943 0.228784431113925 NA NA NA 0.333378374366672 97.208235110675 a2725 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 225 Genentech Cpd 10 AURKA, AURKB 15 34 2.32630161961136 NA 2.59828776616244 3.20325860014864 -0.604970833986192 1.42363118972275 1.67003041144481 0.377963534306667 0.424949128927141 0.362251387663538 0.22878647770878 NA NA NA 0.203693874679214 97.208235110675 a2726 gain_cnaBRCA47_(EGFR) 222 BX-912 PDPK1 (PDK1) 7 42 2.32630161961136 NA 3.24407079523712 3.99039911064193 -0.746328315404804 1.70845030828115 1.46636915929155 0.497734408057773 0.4368451992939 0.508963456218201 0.228853656543484 NA NA NA 0.308973556348944 97.208235110675 a2727 gain_cnaBRCA30_(CRNKL1,FOXA2) 221 TAK-715 p38a 5 44 2.99573227355399 2.32630161961136 4.99781903340144 4.42355426849723 0.574264764904211 1.26658622564181 0.969754495921777 0.575151516454623 0.453395713042133 0.592175408641295 0.229041224664855 NA NA NA 0.375554373944354 97.2122826291986 a2728 PTEN_mut 1033 Vismodegib SMO 7 38 2.30258509299405 NA 4.4312119833469 4.82029925663833 -0.389087273291429 1.06241214287623 0.718169222115648 0.501768188473983 0.366230069846591 0.541776591518669 0.229137259239731 NA NA NA 0.382854223372486 97.2122826291986 a2729 loss_cnaBRCA28_(GPS2) 1007 Docetaxel Microtubules 3 42 -4.38202663467388 NA -3.54653037800914 -4.66161888963558 1.11508851162644 1.19988392752037 1.54398321354136 0.728960896405889 0.929330317750683 0.72221543721892 0.229194643234549 NA NA NA 0.242713573614307 97.2122826291986 a2730 loss_cnaBRCA7_(FAS,PTEN) 1023 GW 441756 NTRK1 4 41 0.693147180559945 NA 3.10999144107635 2.28604731282821 0.823944128248137 0.87163728348523 1.3161595254374 0.638653947486693 0.945283254696963 0.626021475606703 0.2294075841706 NA NA NA 0.154932860579722 97.2122826291986 a2731 PIK3CA_mut 281 CH5424802 ALK 16 32 1.63315443905142 NA 3.83783665090649 3.44394111361772 0.39389553728877 1.1710794486858 0.995804333111716 0.372950560883534 0.336352531615857 0.395555154954904 0.229415346889987 NA NA NA 0.259327783348285 97.2122826291986 a2732 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1268 XAV 939 TNKS1 (tankyrase-1) 6 41 1.6094379124341 NA 4.09403633336884 3.5981362983138 0.495900035055039 0.639856176834299 0.961557298508 0.532472025825465 0.775017969676427 0.515725933155 0.229499985210888 NA NA NA 0.135245786909999 97.2122826291986 a2733 MLL3_mut 1042 BIRB 0796 p38, JNK2 3 40 2.30258509299405 NA 4.98821058493414 4.31997442733426 0.668236157599875 0.813379085327077 0.92014178158944 0.730134929332395 0.821555618597154 0.726231729685802 0.229541795511519 NA NA NA 0.287622974371488 97.2122826291986 a2734 gain_cnaBRCA16 1016 Temsirolimus MTOR 14 30 -1.6094379124341 NA -1.35167027489926 -1.9372672784161 0.58559700351684 1.32635800025107 1.5507282408752 0.39436597200879 0.441507499035698 0.377627096793142 0.229863716942268 NA NA NA 0.206800860216723 97.2122826291986 a2735 gain_cnaBRCA64_(SDHC) 204 Tipifarnib Farnesyl-transferase (FNTA) 8 40 2.77258872223978 NA 2.20960530238671 1.50205077252425 0.707554529862463 2.42271703656807 1.26724488874342 0.471208443239878 0.292050007979783 0.558340803855254 0.229941361351863 NA NA NA 0.445078551599129 97.2122826291986 a2736 gain_cnaBRCA61_(NOTCH2) 177 GSK-650394 SGK3 3 44 2.77258872223978 NA 5.15761333858812 3.93649509345938 1.22111824512873 0.325800027435002 1.71885978720352 0.72615066996945 3.74806059638024 0.710423418023771 0.229975654780149 NA NA NA 0.00181583071916592 97.2122826291986 a2737 loss_cnaBRCA18 258 STF-62247 stimulates autophagy 16 33 2.32630161961136 NA 4.39294958770411 4.74618512001387 -0.353235532309764 0.922503786950708 0.967797133037667 0.370432654785094 0.38290957425483 0.364989231990229 0.230062846979398 NA NA NA 0.225415729112564 97.2122826291986 a2738 gain_cnaBRCA27_(CLTC,PPM1D) 286 KIN001-236 TIE2 9 40 2.32630161961136 NA 4.26148189585477 4.60279396234623 -0.34131206649147 0.559715089853593 0.795848417696903 0.448593905109677 0.609796077823715 0.428865672032356 0.23008567679118 NA NA NA 0.14856912091146 97.2122826291986 a2739 gain_cnaBRCA16 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 16 32 0.246860077931526 2.32630161961136 -0.671807863438797 -0.0615238753256665 -0.610283988113131 1.54188760589625 1.68512403296855 0.372171622722659 0.395803160865536 0.36215968449399 0.230374274925176 NA NA NA 0.219206109549874 97.2122826291986 a2740 gain_cnaBRCA9_(KRAS) 158 PF-562271 FAK 4 41 0.940007258491471 NA 1.59145642620616 2.40562033036813 -0.814163904161967 1.40223149377984 1.26770326219424 0.637285990586534 0.580620181313511 0.64223539407223 0.230389950513153 NA NA NA 0.334627061706213 97.2122826291986 a2741 gain_cnaBRCA64_(SDHC) 1175 AG-014699 PARP1, PARP2 8 35 1.6094379124341 NA 4.25646207741113 3.77130975052826 0.485152326882878 1.12695037595315 0.992818612994047 0.477055595209932 0.430500168627699 0.48866159491088 0.230433318523166 NA NA NA 0.288960862047269 97.2122826291986 a2742 gain_cnaBRCA16 1050 ZM-447439 AURKB 13 26 1.38629436111989 0.693147180559945 3.24785489367076 2.70795867550323 0.539896218167532 1.5761592724002 1.14992668174897 0.414181528403457 0.342539125088146 0.469504905605272 0.23044002189671 NA NA NA 0.286385578783114 97.2122826291986 a2743 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1129 PF-4708671 RPS6KB1 (p70S6KA) 5 38 2.30258509299405 NA 4.38935055358467 3.73260065620986 0.656749897374816 0.70393851542433 1.17144481714252 0.57896671280694 0.932964858413708 0.560632381281783 0.230557363790627 NA NA NA 0.115280855120369 97.2122826291986 a2744 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1010 Gefitinib EGFR 17 28 -0.693147180559945 NA 1.64010522736821 1.25405759983149 0.386047627536722 0.948137481282876 1.07942677267985 0.373886242596002 0.407164187850037 0.357641330850351 0.230615137452484 NA NA NA 0.21696180125197 97.2122826291986 a2745 gain_cnaBRCA62 192 LFM-A13 BTK 9 39 2.77258872223978 NA 5.09836652107418 4.72557095576689 0.372795565307287 1.26131094793736 0.706283546886359 0.449196450745049 0.295561983281699 0.527827056075073 0.230679002614256 NA NA NA 0.413629918826656 97.2122826291986 a2746 PTEN_mut 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 6 37 -1.38629436111989 0.693147180559945 -2.65529485091378 -2.15000568520944 -0.505289165704342 0.940937358520547 0.944042432782938 0.53545435507913 0.537006168507133 0.535239887697423 0.230696023306282 NA NA NA 0.263561532268163 97.2122826291986 a2747 TP53_mut 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 23 3 2.30258509299405 NA 2.58602515948169 3.50050968347582 -0.914484523994123 1.26445226123449 0.206136968953154 0.75447384245456 0.723225820404883 4.43629557880006 0.23095478457322 NA NA NA 0.00454566875915496 97.2122826291986 a2748 loss_cnaBRCA60 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 43 1.38629436111989 NA 3.85432315221982 2.78914083176547 1.06518232045435 0.472693055202506 1.49965704305257 0.725285148475135 2.25343340404699 0.710283944845255 0.231006068607573 NA NA NA 0.0260522923208474 97.2122826291986 a2749 gain_cnaBRCA15 1038 NU-7441 PRKDC (DNAPK) 20 23 0.693147180559945 NA 3.0789897681345 2.73101740483674 0.347972363297762 0.998711498962753 0.878469853784296 0.371720141680375 0.348421304510022 0.396111900480997 0.231016692310455 NA NA NA 0.235703374265275 97.2122826291986 a2750 gain_cnaBRCA48 304 SB52334 ALK5 5 44 2.99573227355399 NA 4.95143224378508 4.22808032782476 0.723351915960317 1.3190364305646 1.25787758472648 0.572635474689157 0.54839419078872 0.575057481541504 0.231053003845432 NA NA NA 0.297061472337706 97.2122826291986 a2751 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 6 43 3.68887945411394 NA 2.90941872685982 3.53620836893224 -0.626789642072424 1.0254974855933 1.20330518480878 0.528643037287533 0.611205440167216 0.520890003621176 0.231176991018655 NA NA NA 0.21222018470335 97.2122826291986 a2752 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 6 39 0.693147180559945 NA 1.28190424983812 0.524594256589181 0.757309993248934 1.39168745959716 1.42730574123438 0.532114063633506 0.544166715038263 0.530587085422908 0.231597717673717 NA NA NA 0.257659810246558 97.2122826291986 a2753 TP53_mut 89 Parthenolide NFKB1 9 5 1.6094379124341 NA 3.59158722888503 2.63476677926804 0.956820449616984 1.2426133232969 1.57226109635565 0.70282406447139 0.770006591494086 0.60856333075645 0.231603717919613 NA NA NA 0.28018616139381 97.2122826291986 a2754 gain_cnaBRCA16 135 Gemcitabine DNA replication 15 32 0.0237165266173161 NA 0.43257978024047 -0.607006625035556 1.03958640527603 2.87263068392708 2.67857229998322 0.379353085186215 0.361893511439779 0.388112131706334 0.231718681516794 NA NA NA 0.248222822451989 97.2122826291986 a2755 loss_cnaBRCA18 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 6 8 1.38629436111989 NA 2.22285452005186 1.69388052427054 0.528973995781314 0.572806018217995 0.89566408247008 0.680260618763651 0.923478418447762 0.590594181607125 0.231762382761056 NA NA NA 0.204288703187411 97.2122826291986 a2756 gain_cnaBRCA63 226 GSK1070916 AURKB 7 42 0.940007258491471 2.32630161961136 3.22313915656102 2.26741580131729 0.95572335524373 1.54977420902054 1.98218366622142 0.494584124620648 0.616685546630532 0.482156810960711 0.23176797779659 NA NA NA 0.179896929539712 97.2122826291986 a2757 loss_cnaBRCA42 277 ABT-869 VEGFR and PDGFR family 3 45 0.0237165266173161 NA 2.37163700457315 2.71237433081481 -0.340737326241663 0.424295084092956 0.473613147744882 0.722549961284653 0.803066872599007 0.719442287157969 0.231794783371892 NA NA NA 0.296237604351673 97.2122826291986 a2758 loss_cnaBRCA33 294 MPS-1-IN-1 MPS1 6 43 2.99573227355399 NA 4.21790478063491 4.8316729944406 -0.613768213805685 1.14496990280132 1.16521271679194 0.527711197049361 0.53605619877345 0.526743490661093 0.231987808318462 NA NA NA 0.262063986511758 97.2122826291986 a2759 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 14 33 2.32630161961136 NA 1.00456257901619 1.59188269301265 -0.587320113996454 1.94785866382629 1.30674778365092 0.386396918156904 0.301520908525646 0.449451777416098 0.232046177232058 NA NA NA 0.314793497294682 97.2122826291986 a2760 loss_cnaBRCA17 1028 VX-702 p38 8 37 0.693147180559945 NA 3.16350576569677 3.48376671096335 -0.320260945266579 0.664428942537224 0.680432197161085 0.472463878237973 0.482009323741398 0.470672826187208 0.232230046594793 NA NA NA 0.245396821311153 97.2122826291986 a2761 loss_cnaBRCA17 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 36 -1.38629436111989 0.693147180559945 0.467931905570584 -0.430599514543749 0.898531420114333 1.42830671574016 1.71293810184314 0.534840620643969 0.629088563550375 0.524555685431658 0.232280956660283 NA NA NA 0.20553975024233 97.2122826291986 a2762 loss_cnaBRCA7_(FAS,PTEN) 140 Vinorelbine Microtubules 4 43 -2.74887219562247 NA -4.54516684589303 -3.51187760594609 -1.03328923994694 0.676145482751042 1.68026183014069 0.632891638963128 1.52820549172758 0.614957277140801 0.232322411570025 NA NA NA 0.0437963262431603 97.2122826291986 a2763 PIK3CA_mut 35 NVP-TAE684 ALK 4 10 0.693147180559945 NA 2.39936924288782 1.52250276276485 0.876866480122968 1.47535491291019 1.06197776668971 0.743744264394492 0.594342739126628 0.825691937841834 0.232614515452127 NA NA NA 0.336088708286715 97.2122826291986 a2764 gain_cnaBRCA12_(TERT) 281 CH5424802 ALK 9 39 1.63315443905142 NA 3.19132334146978 3.66383569171905 -0.472512350249277 1.16456294864566 1.03217312484961 0.447289709830684 0.405742214964671 0.457784008199326 0.232633454959295 NA NA NA 0.286415002893446 97.2122826291986 a2765 PTEN_mut 135 Gemcitabine DNA replication 7 40 0.0237165266173161 NA -1.43079321651791 -0.0729990695476345 -1.35779414697028 2.1489189258705 2.82067633779185 0.495429839003307 0.631849871404642 0.481371835817653 0.232885996424258 NA NA NA 0.173479812841497 97.2122826291986 a2766 gain_cnaBRCA14_(RAD21) 229 LY317615 PRKCB (PKCbeta) 21 28 2.99573227355399 2.32630161961136 3.03947973569204 3.59791057424084 -0.558430838548805 1.53931548900875 1.64553555854655 0.348758353801492 0.362778678273685 0.339361149413294 0.233039457254984 NA NA NA 0.228891839837759 97.2122826291986 a2767 MLL3_mut 1259 BMN-673 PARP1 3 43 2.30258509299405 NA 2.26360854498491 3.37823079599741 -1.1146222510125 0.955660593127018 1.56638846225718 0.721962565671883 1.16633693910653 0.711587373036646 0.233115049767741 NA NA NA 0.166810238487751 97.2122826291986 a2768 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 277 ABT-869 VEGFR and PDGFR family 5 43 0.0237165266173161 NA 2.44987556906503 2.71912507104793 -0.2692495019829 0.346423202101049 0.48184785338637 0.570905843936841 0.777227103582867 0.558785309700244 0.23311936499277 NA NA NA 0.167627778224907 97.2122826291986 a2769 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 279 BIX02189 MAP2K5 (MEK5) 15 34 2.99573227355399 NA 5.25928571301224 4.92503413198627 0.334251581025972 0.57035386658283 0.99879774006577 0.374327625740927 0.586042456464053 0.33465392202826 0.233226320265794 NA NA NA 0.146142510480719 97.2122826291986 a2770 loss_cnaBRCA24 196 Phenformin AAPK1 (AMPK) agonist 3 45 8.29404964010203 NA 5.98855311102581 7.28291041558542 -1.29435730455961 1.21337352651347 1.81912643939498 0.720271722788963 1.06674266108215 0.711526849662028 0.23324700537746 NA NA NA 0.195611364482483 97.2122826291986 a2771 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 287 KIN001-244 PDPK1 (PDK1) 6 43 2.99573227355399 NA 3.04639040031389 3.53834543370044 -0.491955033386541 0.547921562861843 0.971271177042131 0.525937824293425 0.897856676450214 0.506506365075839 0.233536616333171 NA NA NA 0.0962477959897708 97.2122826291986 a2772 gain_cnaBRCA58_(CCND1) 140 Vinorelbine Microtubules 9 38 -2.74887219562247 NA -3.00887348491622 -3.73977744934232 0.730903964426101 1.40590561584073 1.67780968156219 0.44764281393006 0.519881246785562 0.435629840772861 0.233538992081466 NA NA NA 0.198907442086005 97.2122826291986 a2773 MACF1_mut 1192 GSK269962A ROCK1, ROCK2 3 43 1.6094379124341 NA 1.68945772065127 2.73621009746917 -1.0467523768179 2.22989034083616 1.40360587499877 0.721199163482866 0.469418768110989 0.745759472415162 0.233601602172836 NA NA NA 0.502789028821659 97.2122826291986 a2774 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1033 Vismodegib SMO 7 38 2.30258509299405 NA 4.43447281787027 4.81969857659455 -0.385225758724279 0.538895518395466 0.80758099928716 0.496618657554326 0.714843129279066 0.477011914673961 0.233870958737441 NA NA NA 0.13839612308318 97.2122826291986 a2775 gain_cnaBRCA48 333 T0901317 LXR 5 43 2.32630161961136 NA 5.1226350353866 4.69041308633704 0.432221949049559 0.239285879409204 0.790225897626351 0.569930378893036 1.80629943612516 0.546959989982422 0.233906506976916 NA NA NA 0.0153044716193231 97.2122826291986 a2776 gain_cnaBRCA27_(CLTC,PPM1D) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 10 35 2.30258509299405 NA 0.99738434796532 1.47044963457808 -0.473065286612761 1.05027149532638 1.10386724330387 0.432866274971427 0.450421903972317 0.428552699142407 0.233951533061351 NA NA NA 0.233155582943784 97.2122826291986 a2777 MACF1_mut 1529 MLN4924 NEDD8-activating enzyme 3 34 0 NA -0.757629271160981 0.468642732071263 -1.22627200323224 0.714751111157045 1.72268565457403 0.72929635734143 1.71566295468523 0.711837356964271 0.23405243037892 NA NA NA 0.0659463406584437 97.2122826291986 a2778 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 4 39 1.6094379124341 NA 3.68110289414658 2.78455957669726 0.896543317449328 0.455351319622192 1.46364718945846 0.633843527438187 1.96890462114658 0.612540593051693 0.234241000515846 NA NA NA 0.0181791401833147 97.2122826291986 a2779 loss_cnaBRCA33 153 Midostaurin KIT 6 41 -0.669430653942629 NA -0.0512468843727498 0.709271520489913 -0.760518404862663 1.03570386848455 1.48687365433959 0.526775794034566 0.734301017891783 0.511488250964038 0.234441361603114 NA NA NA 0.151857374533157 97.2122826291986 a2780 loss_cnaBRCA23 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 3 46 1.63315443905142 NA 4.2450648338779 3.5330650763011 0.711999757576802 0.726692146744719 1.00237126078467 0.717595696239328 0.979781824760687 0.710315414489673 0.234517682990821 NA NA NA 0.224379595198395 97.2122826291986 a2781 gain_cnaBRCA62 29 AZ628 BRAF 5 9 1.38629436111989 NA 1.59332392853067 2.98206737242901 -1.38874344389834 3.27381085470648 0.759024625018481 0.698161555895135 0.424197824960433 1.82964214614846 0.234531058785703 NA NA NA 0.400057725043717 97.2122826291986 a2782 CDH1_mut 1066 AZD6482 PI3Kbeta 4 39 1.6094379124341 NA 1.14835324975378 2.05117065215654 -0.902817402402759 2.36274530413546 1.32366238227779 0.633285371913063 0.382105257313422 0.682060179763641 0.234646099278747 NA NA NA 0.503484918861287 97.2122826291986 a2783 PTEN_mut 1003 Camptothecin TOP1 7 38 -2.30258509299405 NA -3.18845509824012 -2.40785471825374 -0.780600379986388 1.38165098637404 1.60414019226827 0.495624598251519 0.564976530024394 0.486616059960825 0.234792951194825 NA NA NA 0.212870611301305 97.2122826291986 a2784 loss_cnaBRCA18 266 Zibotentan, ZD4054 Endothelin A Receptor 16 33 2.99573227355399 NA 5.62140883612121 5.80052692311234 -0.179118086991123 0.441454084142364 0.509258217836827 0.366563113144423 0.405745678713348 0.351723508266516 0.234893052122957 NA NA NA 0.214365905425604 97.2122826291986 a2785 gain_cnaBRCA9_(KRAS) 207 AS601245 JNK 4 44 2.07944154167984 NA 1.53276619310625 2.33287657860906 -0.800110385502817 1.50229402852854 1.2557784429539 0.628369882921464 0.532592402225353 0.637142953036176 0.235040904956769 NA NA NA 0.369592969336206 97.2122826291986 a2786 ARID1A_mut 194 AUY922 HSP90 5 42 -1.36257783450257 NA -3.26555465033165 -2.28996045867971 -0.975594191651942 1.66072228233758 1.718677418408 0.569322606054611 0.58745173833564 0.567642409915193 0.235104650319313 NA NA NA 0.27020076889832 97.2122826291986 a2787 MLL3_mut 1502 Bicalutamide ANDR (androgen receptor) 3 42 2.30258509299405 NA 4.16971502527526 4.58605942635421 -0.416344401078947 0.750247064047277 0.568865282778839 0.719616935517667 0.554943059467555 0.731885762205691 0.235118448633857 NA NA NA 0.438945516263452 97.2122826291986 a2788 gain_cnaBRCA63 176 IPA-3 PAK1, PAK2, PAK3 6 41 3.46573590279973 NA 5.18371529143905 4.39632103418385 0.787394257255202 1.66771579068947 1.47455961990278 0.525892776802667 0.472139354709638 0.533986043444697 0.235214285942398 NA NA NA 0.314009937550708 97.2122826291986 a2789 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 286 KIN001-236 TIE2 6 43 2.32630161961136 NA 4.19010563017676 4.58894097152283 -0.398835341346064 0.745900115523916 0.762894704245242 0.524021577333967 0.534703418119093 0.522792122067024 0.235218696509251 NA NA NA 0.263328385459038 97.2122826291986 a2790 loss_cnaBRCA29_(MAP2K4) 1032 Afatinib ERBB2, EGFR 6 39 -0.693147180559945 NA 1.12142621050611 0.16263254268576 0.958793667820345 1.73878573488801 1.8262864842502 0.527874572678835 0.551415650923833 0.524996311416052 0.235275365165969 NA NA NA 0.25290201374553 97.2122826291986 a2791 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 306 TG101348 JAK2 7 41 2.32630161961136 NA 3.75967724324736 3.13358361016611 0.626093633081259 1.4614442214109 1.24229589348362 0.491816925953836 0.428407477965062 0.503981085637804 0.235282165150097 NA NA NA 0.317859021180594 97.2122826291986 a2792 loss_cnaBRCA42 273 CUDC-101 HDAC, EGFR 3 46 1.63315443905142 NA -1.07269434127053 0.0415718689211083 -1.11426621019164 0.606530276602092 1.58564749047511 0.715842478963262 1.83711556236564 0.702720003585268 0.235645694430222 NA NA NA 0.0551591304819864 97.2122826291986 a2793 loss_cnaBRCA57 290 KIN001-260 IKK 5 44 2.99573227355399 NA 5.57038454893477 4.98426557661122 0.586118972323558 0.453042928757947 1.07205673226695 0.566898087480511 1.29373826434163 0.546723839030574 0.235688909283754 NA NA NA 0.0464662789930635 97.2122826291986 a2794 PTEN_mut 1114 Cetuximab EGFR 8 37 4.18661983833127 NA 5.94705875456194 6.35513128228359 -0.408072527721649 1.27392345162616 0.767606736858835 0.468866031621349 0.320327353422017 0.531616657497751 0.235746377424793 NA NA NA 0.407995088165015 97.2122826291986 a2795 gain_cnaBRCA30_(CRNKL1,FOXA2) 1042 BIRB 0796 p38, JNK2 4 39 2.30258509299405 NA 4.89120866883378 4.31278908135481 0.578419587478967 0.702967158137034 0.930376671613265 0.631700999047366 0.822825904145883 0.62170474080782 0.235798809651559 NA NA NA 0.201550750673457 97.2122826291986 a2796 gain_cnaBRCA16 1262 UNC1215 LMBL3 16 30 0 NA 2.90047679833381 2.68127684931875 0.219199949015063 0.697235013047614 0.524511939544845 0.372085470828231 0.314384597607828 0.417912219892034 0.235814216565446 NA NA NA 0.281198253108853 97.2122826291986 a2797 loss_cnaBRCA24 211 TL-2-105 CRAF 3 46 2.32630161961136 1.63315443905142 4.63290344098912 3.8602483210108 0.772655119978315 0.459594877415327 1.09943074541011 0.715451990618587 1.68116564815426 0.702777435690231 0.235897471436318 NA NA NA 0.0720634890956344 97.2122826291986 a2798 loss_cnaBRCA29_(MAP2K4) 224 AS605240 PI3Kgamma 7 42 2.99573227355399 2.32630161961136 2.61124396861953 3.38009221277458 -0.768848244155058 2.97312694798334 1.23564054740454 0.490165794011197 0.258599197951021 0.622226460413607 0.235901056069641 NA NA NA 0.523751019481492 97.2122826291986 a2799 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 18 28 2.30258509299405 NA 1.63127150090028 1.27296996738988 0.358301533510402 0.793518315190396 1.09133809983136 0.36302721839223 0.451535303787452 0.328313960234477 0.235929785493702 NA NA NA 0.204975040287928 97.2122826291986 a2800 gain_cnaBRCA30_(CRNKL1,FOXA2) 222 BX-912 PDPK1 (PDK1) 5 44 2.32630161961136 NA 4.64697810112076 3.79705381154584 0.849924289574918 1.7129233091745 1.47880297811739 0.566559058596334 0.496183503968149 0.574738015916714 0.235964961303013 NA NA NA 0.338345125309661 97.2122826291986 a2801 loss_cnaBRCA57 272 AR-42 HDAC 5 44 1.63315443905142 NA 0.914260701426349 0.054208156544997 0.860052544881352 1.9373788695574 1.47328141761185 0.566453117138757 0.443925841452908 0.583766641321978 0.236051271824136 NA NA NA 0.38462920903806 97.2122826291986 a2802 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 29 AZ628 BRAF 5 9 1.38629436111989 NA 3.37605184644468 1.9916629735879 1.38438887285678 0.851081825394227 2.3617194764466 0.695688082969683 1.62662253093646 0.586178369896709 0.236095986403397 NA NA NA 0.14173844947992 97.2122826291986 a2803 loss_cnaBRCA42 305 TPCA-1 IKK 3 46 2.99573227355399 NA 3.25830303283904 4.23832788736418 -0.980024854525134 0.871712458881487 1.38841228111558 0.715138071042914 1.12425243500893 0.705860116519343 0.236100021223637 NA NA NA 0.178672333644598 97.2122826291986 a2804 gain_cnaBRCA10_(MDM2,NUP107) 301 PHA-793887 CDK-pan 5 43 2.32630161961136 NA 3.74968126690853 2.82605928280219 0.923621984106343 1.08239866898247 1.67164865995406 0.567024146049824 0.85331034726291 0.552521595136939 0.236263191846014 NA NA NA 0.138656763814822 97.2122826291986 a2805 gain_cnaBRCA16 60 BI-2536 PLK1, PLK2, PLK3 3 9 -1.36257783450257 NA -2.45190614909476 -1.17983920582012 -1.27206694327465 1.66738318795545 1.47358633751932 0.840019028467959 0.762912180273606 0.863245614380545 0.236269515048547 NA NA NA 0.321017886642962 97.2122826291986 a2806 gain_cnaBRCA9_(KRAS) 185 OSI-906 IGF1R 4 44 0.940007258491471 NA 2.25071574353187 2.9519239279662 -0.701208184434329 1.47099258710669 1.09030278102656 0.626590707358411 0.476690494962685 0.643131611362226 0.236348735535756 NA NA NA 0.414953538622361 97.2122826291986 a2807 gain_cnaBRCA31 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 13 29 -1.38629436111989 0.693147180559945 0.163319308311926 -0.510935934420914 0.674255242732841 1.36699896123439 1.79824252494331 0.401215967871225 0.493237567733037 0.374952340065529 0.236410536930542 NA NA NA 0.192032669537898 97.2122826291986 a2808 gain_cnaBRCA63 274 PXD101, Belinostat HDAC 7 41 2.99573227355399 NA 1.29331447986937 0.565340469445757 0.727974010423617 2.235671718976 1.3352942971927 0.490533933700666 0.325617578039162 0.545178701020512 0.236487192745426 NA NA NA 0.431536982034743 97.2122826291986 a2809 POLR2B_mut 277 ABT-869 VEGFR and PDGFR family 3 45 0.0237165266173161 NA 2.37482500132242 2.71216179769819 -0.337336796375768 0.504978162783181 0.470158243303422 0.715112336709952 0.668022542829456 0.717496292323994 0.236560371486362 NA NA NA 0.366723618178065 97.2122826291986 a2810 CDH1_mut 300 CX-5461 RNA Pol I 4 45 2.32630161961136 NA 2.93884449999343 3.99890047484419 -1.06005597485077 1.63586086838886 1.69892550522653 0.625412746557264 0.64801108415461 0.623956713575517 0.236659693020067 NA NA NA 0.290297468172206 97.2122826291986 a2811 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 309 Y-39983 ROCK 7 42 2.99573227355399 NA 5.38590236075613 4.85982735500145 0.526075005754678 1.05489571314922 1.07802767026289 0.489325501903116 0.49869859095755 0.487997683423457 0.2366931525714 NA NA NA 0.257078608561742 97.2122826291986 a2812 BRCA2_mut 1241 CHIR-99021 GSK3B 5 41 2.30258509299405 NA 3.74035660626037 4.29138105422189 -0.55102444796152 0.51915614589892 1.00367661733406 0.568250656719466 1.06138481132188 0.549005963121007 0.236713043751475 NA NA NA 0.0834108605841934 97.2122826291986 a2813 gain_cnaBRCA64_(SDHC) 1494 SN-38 TOP1 9 39 -2.99573227355399 NA -2.7021254844831 -3.44263382348678 0.740508339003676 1.82219707561953 1.63664313524525 0.443313396036095 0.406382135561222 0.45245559221602 0.236748248035553 NA NA NA 0.286456093537702 97.2122826291986 a2814 gain_cnaBRCA13_(FGFR1,WHSC1L1) 254 AC220 FLT3 11 37 0.0237165266173161 NA 2.50186987049849 2.14108114838346 0.360788722115033 0.580199379340698 0.942267528698729 0.4116828035876 0.621835760191627 0.382894147496817 0.236753013016943 NA NA NA 0.134139198900443 97.2122826291986 a2815 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 222 BX-912 PDPK1 (PDK1) 15 34 2.32630161961136 NA 4.27046220482658 3.71318603356535 0.557276171261229 1.40432891306374 1.53910982261906 0.371460715359236 0.396827385719385 0.36207693763719 0.236771353460771 NA NA NA 0.223894620126955 97.2122826291986 a2816 PIK3CA_mut 271 VNLG/124 HDAC, RAR 17 32 1.63315443905142 NA 4.34095200612649 4.05076190849229 0.290190097634203 0.987423784997009 0.695816346765124 0.359589080081886 0.29388607206285 0.417049842222459 0.236869233135759 NA NA NA 0.291522289749076 97.2122826291986 a2817 gain_cnaBRCA9_(KRAS) 273 CUDC-101 HDAC, EGFR 4 45 1.63315443905142 NA -0.919856261203715 0.05274773314165 -0.972603994345365 1.31187184858556 1.57203555043353 0.624774139206796 0.741386436025752 0.618690839451529 0.237131588945195 NA NA NA 0.238454510812087 97.2122826291986 a2818 loss_cnaBRCA28_(GPS2) 156 AZD6482 PI3Kbeta 4 43 1.63315443905142 NA 1.22277613616862 2.13056874760196 -0.907792611433339 1.3445981869652 1.4574918282973 0.625960685025039 0.675140439897705 0.622845764078043 0.237395682147731 NA NA NA 0.274475795469751 97.2122826291986 a2819 gain_cnaBRCA62 326 GSK690693 AKT 10 38 2.32630161961136 NA 2.29483978974949 3.10924626649882 -0.814406476749328 1.88095879989503 1.92297241121767 0.425316424234936 0.432974117665297 0.423514384293027 0.237556989014314 NA NA NA 0.244864722185194 97.2122826291986 a2820 gain_cnaBRCA19 309 Y-39983 ROCK 4 45 2.99573227355399 NA 4.31867663035867 4.98976353142043 -0.671086901061758 1.32453774074027 1.05601818158594 0.624172088407934 0.506657440116955 0.635488017880441 0.23757709973661 NA NA NA 0.389986572949454 97.2122826291986 a2821 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1203 QL-XII-61 BTK 5 18 2.30258509299405 NA 3.51160053390317 4.42343617811595 -0.911835644212776 1.90832295434332 1.36473087074158 0.614565802219356 0.477820403583916 0.668143194941649 0.237590290165969 NA NA NA 0.36170247657848 97.2122826291986 a2822 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1059 AZD8055 MTORC1/2 8 35 0.693147180559945 NA -0.251421080401926 0.217711148289553 -0.469132228691479 1.1887960761455 0.955183206493141 0.469628456620302 0.394628009046407 0.491143715155808 0.237645539792291 NA NA NA 0.324107655467553 97.2122826291986 a2823 gain_cnaBRCA8_(CHD4,WNK1) 207 AS601245 JNK 3 45 2.07944154167984 NA 1.41452401076933 2.32297915997591 -0.908455149206581 1.33321161231693 1.27075548477684 0.713333666590307 0.681403567756071 0.714893746349731 0.237710567001923 NA NA NA 0.359030142551412 97.2122826291986 a2824 loss_cnaBRCA34 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 5 43 2.32630161961136 NA 4.60889567816283 4.99914095293234 -0.390245274769507 0.671635558621918 0.692247588696286 0.565179967878669 0.581037245214092 0.563736560649432 0.23776761674635 NA NA NA 0.27444940415498 97.2122826291986 a2825 gain_cnaBRCA27_(CLTC,PPM1D) 329 QL-XI-92 DDR1 9 39 2.32630161961136 NA 3.9157832161921 4.33123168634663 -0.415448470154529 1.1926312519359 0.876753241766548 0.442272260361781 0.348346120798163 0.473848798457195 0.237834369901721 NA NA NA 0.347475694530663 97.2122826291986 a2826 loss_cnaBRCA7_(FAS,PTEN) 165 DMOG Prolyl-4-Hydroxylase 4 42 8.29404964010203 NA 6.6994460775292 7.65288862553319 -0.95344254800399 1.28185708781825 1.53880989360964 0.62616556644703 0.743797851620709 0.61959736024797 0.237853561906506 NA NA NA 0.237675889141846 97.2122826291986 a2827 gain_cnaBRCA14_(RAD21) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 20 26 1.38629436111989 NA 3.15409781531215 2.63131034293583 0.522787472376314 1.24207110738583 1.62091201267177 0.355794252946661 0.420899793311043 0.322526743147887 0.238005877872563 NA NA NA 0.222109818408237 97.2122826291986 a2828 loss_cnaBRCA17 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 10 37 2.32630161961136 NA 0.90674493572895 1.5548258275231 -0.648080891794145 0.675742689446798 1.6661790571119 0.426198614325884 0.959064599462707 0.388962332126241 0.238032165107901 NA NA NA 0.0699467651369076 97.2122826291986 a2829 PTEN_mut 333 T0901317 LXR 9 39 2.32630161961136 NA 4.46298985903133 4.79830843995241 -0.335318580921082 0.754715883758883 0.759397742291229 0.442031313286114 0.44429776573804 0.441558569702051 0.238086245105116 NA NA NA 0.25320552276468 97.2122826291986 a2830 TP53_mut 271 VNLG/124 HDAC, RAR 38 11 1.63315443905142 NA 4.22554670622542 3.89543548539431 0.330111220831117 0.842833978641452 0.658080739503321 0.409021958748654 0.391668144850088 0.501627233582713 0.238222041552716 NA NA NA 0.18551789975779 97.2122826291986 a2831 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1031 Elesclomol HSP70 17 27 -1.6094379124341 NA -2.57524269144128 -3.23090197594855 0.655659284507274 1.4041864553475 1.96177618695537 0.370388520007209 0.466931782464043 0.33421716955635 0.238292142098188 NA NA NA 0.204410239982206 97.2122826291986 a2832 CDH1_mut 330 XMD13-2 RIPK 4 44 2.32630161961136 NA 3.03092990226213 3.78375682087721 -0.752826918615077 0.724008777097914 1.23389003013687 0.623604129608475 1.03980358032768 0.610124808717006 0.238556034720064 NA NA NA 0.126399188603015 97.2122826291986 a2833 gain_cnaBRCA12_(TERT) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 9 40 3.68887945411394 NA 3.03299807165502 3.55541223950875 -0.522414167853732 0.736907499831685 1.25872381608992 0.440399894908922 0.708927739198007 0.415034784577727 0.238580221596364 NA NA NA 0.113924746301094 97.2122826291986 a2834 loss_cnaBRCA29_(MAP2K4) 211 TL-2-105 CRAF 7 42 2.32630161961136 1.63315443905142 3.45661613232029 3.98271000388624 -0.52609387156595 0.861698328807993 1.10852193548997 0.487052883821086 0.610531382013597 0.474590402519563 0.238845140536779 NA NA NA 0.18423348590635 97.2122826291986 a2835 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 300 CX-5461 RNA Pol I 9 40 2.32630161961136 NA 4.52142400010233 3.77532708417604 0.746096915926294 0.715033829612115 1.83257865422207 0.440120664467431 1.04344282050407 0.407129546231135 0.238873667443112 NA NA NA 0.0548626262322882 97.2122826291986 a2836 gain_cnaBRCA16 11 Paclitaxel Microtubules 3 9 -2.27886856637673 NA -4.17061028058269 -2.7354022194464 -1.43520806113629 1.42554136401754 1.78471074829059 0.834961459476962 1.00678107094101 0.804168441586931 0.238906597218424 NA NA NA 0.225124746539887 97.2122826291986 a2837 loss_cnaBRCA20 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 44 2.99573227355399 NA 2.90336641955231 3.91204617396875 -1.00867975441644 1.02564030725502 1.43200139734966 0.712133913995111 0.983463449399742 0.704384616022926 0.23895209617621 NA NA NA 0.222845541161106 97.2122826291986 a2838 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 39 1.6094379124341 NA 3.47142031910916 2.47461535446103 0.996804964648135 1.8481039468401 1.56739360357415 0.627073146200364 0.539366287460442 0.635963399604993 0.239189580224512 NA NA NA 0.365114494318516 97.2122826291986 a2839 gain_cnaBRCA19 167 OSU-03012 PDPK1 (PDK1) 4 44 2.77258872223978 NA 1.57721491284573 2.30895758346963 -0.731742670623905 0.286861546975181 1.21295445557338 0.622748763716993 2.55085660082288 0.603272997812603 0.239190972292196 NA NA NA 0.00571464782951904 97.2122826291986 a2840 gain_cnaBRCA48 310 YM201636 FYV1 5 44 1.63315443905142 NA 2.92462146066206 2.35671816824687 0.567903292415187 0.840682801269589 1.023692073495 0.562609473078885 0.675526240762326 0.554759880553047 0.239198292054631 NA NA NA 0.216559307762665 97.2122826291986 a2841 loss_cnaBRCA23 304 SB52334 ALK5 3 46 2.99573227355399 NA 3.45908620437812 4.35685732674088 -0.897771122362756 1.11136147521922 1.270218536923 0.71033756158368 0.807811987711439 0.706784774640066 0.239213274530206 NA NA NA 0.294016129121884 97.2122826291986 a2842 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 193 GW-2580 CSF1R (cFMS) 14 34 2.99573227355399 NA 5.26489525447862 5.54512153172464 -0.28022627724602 0.847121375421164 0.693386283224772 0.378644477623248 0.330798260292629 0.40414165094636 0.239227308990613 NA NA NA 0.285853576138322 97.2122826291986 a2843 BRCA1_mut 295 NVP-BHG712 EPHB4 4 45 2.32630161961136 NA 4.5833146787955 3.8247876810642 0.758526997731296 0.563751545184003 1.25207312396794 0.621846208376352 1.34549874711868 0.605816851437121 0.23930395697322 NA NA NA 0.0650970134031715 97.2122826291986 a2844 PTEN_mut 179 5-Fluorouracil DNA antimetabolite 9 40 3.46573590279973 NA 3.46496714681721 4.17119133483222 -0.706224188015009 2.00727515682502 1.51079506542571 0.439692662152234 0.351832276513634 0.467452008665391 0.239323969091481 NA NA NA 0.343339475749218 97.2122826291986 a2845 loss_cnaBRCA29_(MAP2K4) 262 VX-11e ERK 7 42 1.63315443905142 NA 3.22616867920958 3.86858582216908 -0.642417142959501 2.55354088483729 1.02242228530806 0.486412839178806 0.251578953277827 0.62832858026558 0.239453775626492 NA NA NA 0.534408921271503 97.2122826291986 a2846 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 6 40 2.30258509299405 NA 1.86106246932877 1.34599178217872 0.515070687150051 0.803332277429438 1.00839607576819 0.521727491887912 0.641167673230076 0.510782121754759 0.239763488416708 NA NA NA 0.197486310733238 97.2122826291986 a2847 NF1_mut 1024 CEP-701 FLT3, JAK2, NTRK1, RET 4 41 0.693147180559945 NA 1.43574681939572 0.546527176303021 0.889219643092704 1.95155820228508 1.37634013681706 0.624438185349878 0.455645976661887 0.646075500747312 0.239767678585743 NA NA NA 0.433623770797079 97.2122826291986 a2848 PTEN_mut 201 Epothilone B Microtubules 8 40 -3.44201937618241 NA -4.92405931800452 -4.09809764612678 -0.82596167187774 1.09795733402708 1.88848033198678 0.461215339237214 0.752271191493649 0.437368426817971 0.239820262379324 NA NA NA 0.1103003540327 97.2122826291986 a2849 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 329 QL-XI-92 DDR1 14 34 2.32630161961136 NA 4.00170359951319 4.35694806823714 -0.355244468723955 1.01047429242124 0.909983398271914 0.378131535845771 0.351562104437846 0.390385659121446 0.23985475626867 NA NA NA 0.266894663290513 97.2122826291986 a2850 gain_cnaBRCA30_(CRNKL1,FOXA2) 308 XL-880 MET 5 44 1.63315443905142 NA 2.65107056222424 1.75644041397648 0.894630148247759 2.21730539649344 1.52129811392425 0.561805239345777 0.403476286876211 0.588070240841899 0.239860613136694 NA NA NA 0.424428438599245 97.2122826291986 a2851 ASH1L_mut 1527 GDC0941 (rescreen) PI3K 3 42 1.38629436111989 NA 1.74277013192011 0.926219106323865 0.816551025596244 1.76197896243489 1.10800881634097 0.712071591697738 0.463428362656413 0.736953545453525 0.239983271738963 NA NA NA 0.507655142869535 97.2122826291986 a2852 gain_cnaBRCA16 170 Shikonin unknown 16 31 2.77258872223978 NA 0.288217372171628 -0.143287149049794 0.431504521221422 0.878744005220626 1.30135957894256 0.366469390983116 0.491046901780097 0.331579778720379 0.240092156470972 NA NA NA 0.185848741413487 97.2122826291986 a2853 loss_cnaBRCA34 1023 GW 441756 NTRK1 5 40 0.693147180559945 NA 3.00772303077964 2.2782322609091 0.729490769870537 0.705624847426037 1.33673615439002 0.565011307127556 1.03382239518855 0.545725323187223 0.240128974996627 NA NA NA 0.090023943317887 97.2122826291986 a2854 loss_cnaBRCA28_(GPS2) 291 KIN001-266 MAP3K8 (COT) 4 45 2.99573227355399 NA 3.11107122072463 3.8379733590273 -0.726902138302668 0.21911978002152 1.20907653965429 0.6206675146367 3.31737343945526 0.601204402254392 0.24018256268807 NA NA NA 0.00184386245920714 97.2122826291986 a2855 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 4 39 0.693147180559945 NA 0.741685315970109 1.77838411966735 -1.03669880369724 2.33645189305639 1.59094413990001 0.62568323266275 0.443706462255084 0.651624892224313 0.240214883792562 NA NA NA 0.444523418417745 97.2122826291986 a2856 gain_cnaBRCA16 140 Vinorelbine Microtubules 16 31 -2.74887219562247 NA -3.20510125886868 -3.80354142894694 0.598440170078259 1.59600438358113 1.65195518733224 0.366350550450295 0.374961482709386 0.362261745758786 0.240242309950892 NA NA NA 0.237761520737926 97.2122826291986 a2857 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1373 Dabrafenib BRAF 6 40 2.30258509299405 NA 4.94972977230627 4.10431803541931 0.845411736886958 1.01143382949936 1.68451149939718 0.521166827060856 0.835854716571444 0.501873532587635 0.240261017914595 NA NA NA 0.116664981445697 97.2122826291986 a2858 gain_cnaBRCA58_(CCND1) 290 KIN001-260 IKK 10 39 2.99573227355399 NA 5.39107077862213 4.95510000844477 0.435970770177363 0.628156751746594 1.1088104552832 0.421549615551036 0.694047734049094 0.393187824032567 0.240304458668701 NA NA NA 0.114143293205742 97.2122826291986 a2859 gain_cnaBRCA16 1129 PF-4708671 RPS6KB1 (p70S6KA) 15 28 2.30258509299405 NA 4.09075010838252 3.65801164564858 0.432738462733945 1.26226327349755 1.06331113439222 0.38120919802878 0.342827421045761 0.40697256780001 0.240351989171093 NA NA NA 0.269197932401816 97.2122826291986 a2860 gain_cnaBRCA12_(TERT) 290 KIN001-260 IKK 9 40 2.99573227355399 NA 4.6736961627021 5.12740856628121 -0.45371240357911 1.77371625220077 0.802281675955619 0.438702630578176 0.255797624347275 0.56552756616145 0.240367949358747 NA NA NA 0.472756626589957 97.2122826291986 a2861 loss_cnaBRCA57 1218 JQ1 BRD2, BRD3, BRD4 5 41 0 NA 2.80796323683904 2.41530121775955 0.392662019079493 0.224860539945974 0.727037850575966 0.563755696758329 1.74624689229082 0.540084699535825 0.240383059501561 NA NA NA 0.0186357009313836 97.2122826291986 a2862 gain_cnaBRCA10_(MDM2,NUP107) 304 SB52334 ALK5 5 44 2.99573227355399 NA 4.93870746465795 4.22952632545284 0.709181139205113 0.33096711482333 1.31758609101018 0.56107646297541 2.14275409079139 0.538242733468288 0.240461943371698 NA NA NA 0.0085524104075504 97.2122826291986 a2863 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1028 VX-702 p38 6 39 0.693147180559945 NA 3.12008343086384 3.47402343194961 -0.353940001085769 0.749320122984473 0.668337798474188 0.521841961086089 0.472348186347991 0.529582498392 0.240581993069979 NA NA NA 0.314861836640367 97.2122826291986 a2864 gain_cnaBRCA13_(FGFR1,WHSC1L1) 222 BX-912 PDPK1 (PDK1) 11 38 2.32630161961136 NA 4.35733824866726 3.7466983546916 0.610639893975664 1.56734049963547 1.48203806986638 0.406932204170786 0.389602574627329 0.412027131010689 0.240593389978201 NA NA NA 0.266832483239659 97.2122826291986 a2865 TP53_mut 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 37 11 2.32630161961136 NA 5.02307741086759 4.74124319680034 0.281834214067255 0.714769954393503 0.595603420268194 0.408091314951769 0.394300589070504 0.473191060488451 0.240805882514699 NA NA NA 0.204417366429774 97.2122826291986 a2866 loss_cnaBRCA28_(GPS2) 205 BMS-708163 g-secretase 4 44 2.32630161961136 0.940007258491471 5.27988107572515 4.86167937597367 0.418201699751488 0.546909786798055 0.681884184856416 0.620563801110602 0.764663039218765 0.613303122493666 0.240818455710043 NA NA NA 0.227239348614984 97.2122826291986 a2867 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 346 THZ-2-102-1 CDK7 6 42 0.916290731874155 2.99573227355399 -2.48082308659462 -1.1714911461194 -1.30933194047522 2.92768912216818 2.47190382166683 0.518458287354429 0.447223692762011 0.529685632992114 0.24095576076568 NA NA NA 0.336478479866998 97.2122826291986 a2868 gain_cnaBRCA15 88 MS-275 HDAC 6 8 1.6094379124341 NA 0.483074920124555 1.63124539942798 -1.14817047930342 1.69156224201441 1.74574156042489 0.666234129656973 0.678763364885773 0.657697854786692 0.240959411326197 NA NA NA 0.240641870788252 97.2122826291986 a2869 gain_cnaBRCA13_(FGFR1,WHSC1L1) 292 Masitinib KIT 11 37 2.99573227355399 NA 4.35030799246294 3.90925206458505 0.441055927877895 1.17268532307775 1.05455185221253 0.407882270658912 0.376107655820513 0.418240152869227 0.241043326890902 NA NA NA 0.280156333675281 97.2122826291986 a2870 gain_cnaBRCA48 208 SB-715992 KIF11 5 44 -2.05572501506252 NA -0.386887913087284 -1.33683239384883 0.949944480761543 1.09010054313241 1.74114465561662 0.56027484559575 0.871428316173365 0.545586191071025 0.24112464168901 NA NA NA 0.132496605105973 97.2122826291986 a2871 loss_cnaBRCA18 1 Erlotinib EGFR 4 8 0.693147180559945 NA 2.6473358795015 3.06619095209414 -0.418855072592641 0.872228389626572 0.323323160184458 0.762928915748928 0.480212611254222 1.29546881934991 0.241214818213253 NA NA NA 0.413673920620443 97.2122826291986 a2872 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 298 OSI-930 KIT, VEGFR, PDGFR 5 43 2.32630161961136 NA 3.47750385754024 3.96404909166339 -0.486545234123146 1.16966466610955 0.832811103071514 0.560980641322354 0.415969848641711 0.584220398033486 0.241219345250018 NA NA NA 0.41198701910453 97.2122826291986 a2873 loss_cnaBRCA34 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 5 41 1.63315443905142 NA 1.14435849918457 2.0332091780467 -0.88885067886213 1.12548894926468 1.61809776669915 0.562679205190077 0.789746251567235 0.549318278014404 0.241268109837889 NA NA NA 0.163771838107519 97.2122826291986 a2874 loss_cnaBRCA38 1219 PFI-1 BRD2, BRD3, BRD4 3 44 2.30258509299405 NA 2.51569082998262 3.21726221464977 -0.701571384667154 0.362751073026577 1.01001359608429 0.708463965074754 1.93402979848871 0.694615782784576 0.241344030080163 NA NA NA 0.0460235322096934 97.2122826291986 a2875 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 153 Midostaurin KIT 9 38 -0.669430653942629 NA 1.1260909786144 0.490469269113694 0.635621709500703 1.14823213685791 1.50076648808174 0.440060541389161 0.553565510925389 0.423531385161156 0.241428598250686 NA NA NA 0.181170891357108 97.2122826291986 a2876 gain_cnaBRCA14_(RAD21) 9 MG-132 Proteasome 6 8 0 NA -0.256998492352268 0.768731144022323 -1.02572963637459 1.9632994870338 1.14861714362918 0.665488188049087 0.522451945385208 0.8930126474812 0.241456537560735 NA NA NA 0.288578441182947 97.2122826291986 a2877 loss_cnaBRCA60 175 PAC-1 CASP3 agonist 3 45 0.940007258491471 NA 1.59665522404559 2.45503023897761 -0.85837501493202 1.30708430607128 1.20907584882845 0.707353783272175 0.656709755403649 0.709943065824821 0.241607423429391 NA NA NA 0.373379158970647 97.2203708643424 a2878 gain_cnaBRCA8_(CHD4,WNK1) 254 AC220 FLT3 4 44 0.0237165266173161 NA 1.7259654518745 2.26901611950394 -0.543050667629446 0.752327576868462 0.884675475218782 0.619458841482287 0.72182741179032 0.61384166605856 0.24164455250676 NA NA NA 0.248771763132395 97.2203708643424 a2879 gain_cnaBRCA58_(CCND1) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 8 35 1.6094379124341 NA 3.40395347948204 2.74544592091209 0.658507558569951 1.0880761250953 1.47362186871208 0.465293534294011 0.60520357296901 0.446863318569964 0.241930716302061 NA NA NA 0.173349133229519 97.2480394260729 a2880 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 190 Bleomycin DNA damage 6 42 4.15888308335967 NA 0.846120075972281 2.25443902495187 -1.40831894897959 2.91667169466584 2.69854117648549 0.517175357270451 0.482851378698257 0.521881585966291 0.242104501019353 NA NA NA 0.305080521394621 97.2480394260729 a2881 loss_cnaBRCA29_(MAP2K4) 1371 PLX4720 (rescreen) BRAF 7 40 2.30258509299405 NA 4.3148699771437 4.77579588293926 -0.460925905795559 1.98947317235942 0.656114343816836 0.485636923631215 0.231682393208109 0.702508503493765 0.242106188259103 NA NA NA 0.565163785521294 97.2480394260729 a2882 POLR2B_mut 310 YM201636 FYV1 3 46 1.63315443905142 NA 3.08360012632041 2.3710414418959 0.712558684424514 1.11510505636114 1.00465348337357 0.70578334998068 0.639005876943799 0.709258163353779 0.242194323112827 NA NA NA 0.384003775947829 97.2480394260729 a2883 gain_cnaBRCA47_(EGFR) 152 CP466722 ATM 7 42 2.77258872223978 NA 2.29350155240578 2.80291512872248 -0.509413576316695 0.426767652976459 1.11619845119643 0.483492459135753 1.19365554714334 0.456382622436599 0.242245167767927 NA NA NA 0.0414984522045473 97.2480394260729 a2884 loss_cnaBRCA17 1067 CCT007093 PPM1D 9 37 1.88706964903238 NA 4.43212088967738 4.00135617007004 0.430764719607338 0.760512827671017 1.02002837684635 0.440464006358578 0.566413483026322 0.422306603801695 0.242340838938098 NA NA NA 0.175763708333682 97.2480394260729 a2885 loss_cnaBRCA29_(MAP2K4) 1003 Camptothecin TOP1 6 39 -2.30258509299405 NA -3.23906361501646 -2.42008418695446 -0.818979428061999 1.44788835285896 1.59189363174352 0.519714668933987 0.565637140767703 0.51446868793929 0.242473946564516 NA NA NA 0.243906038454457 97.2480394260729 a2886 NF1_mut 1032 Afatinib ERBB2, EGFR 4 41 -0.693147180559945 NA -0.737246413501633 0.390736880043605 -1.12798329354524 1.95310266598585 1.8066445793838 0.620710410223846 0.577534050405833 0.624352629408695 0.242540070458421 NA NA NA 0.337138113300063 97.2480394260729 a2887 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 17 28 2.30258509299405 NA 3.46974664405173 2.99904718110558 0.47069946294615 1.11393482064584 1.38668518905789 0.364335099806364 0.422555659650936 0.339442193989208 0.24254697009459 NA NA NA 0.218439961337866 97.2480394260729 a2888 gain_cnaBRCA64_(SDHC) 1166 QL-VIII-58 MTOR, ATR 6 20 2.30258509299405 NA -1.04482655042635 -1.66128723042923 0.616460680002876 1.46434256425161 0.989937634051932 0.557536339162611 0.420981193234613 0.62272678479717 0.242698535732765 NA NA NA 0.368466623659731 97.2480394260729 a2889 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1114 Cetuximab EGFR 9 36 4.18661983833127 NA 6.59001020496663 6.20572876767469 0.384281437291934 0.581621368677983 0.924243870105213 0.441313121433381 0.660707219484387 0.415779265323327 0.242851372706698 NA NA NA 0.136755599791265 97.2480394260729 a2890 gain_cnaBRCA62 1021 Axitinib PDGFR, KIT, VEGFR 8 37 0.693147180559945 NA 2.90281801688391 2.36711593494481 0.535702081939095 1.49118071348885 1.08536575950708 0.461360983035651 0.359246922316837 0.49356825314112 0.243206563113426 NA NA NA 0.361875008348462 97.2480394260729 a2891 gain_cnaBRCA16 155 AP-24534 ABL 16 31 -0.669430653942629 NA 1.71574795102806 1.3058045660164 0.409943385011661 1.07813255084182 1.14944799169 0.364012933824536 0.380234679577731 0.356643700259056 0.243209773732711 NA NA NA 0.236049193704784 97.2480394260729 a2892 gain_cnaBRCA13_(FGFR1,WHSC1L1) 165 DMOG Prolyl-4-Hydroxylase 10 36 8.29404964010203 NA 7.06595613023653 7.70998736889293 -0.6440312386564 1.69526206058617 1.47574259045577 0.422809024014849 0.379900697142785 0.436411636298642 0.24323480969742 NA NA NA 0.294636132268281 97.2480394260729 a2893 loss_cnaBRCA20 1001 AICAR AAPK1 (AMPK) agonist 3 42 7.60090245954208 NA 6.83450842321347 7.80305292944874 -0.968544506235276 1.38771883523525 1.36896697112825 0.707046868324799 0.697940016120836 0.707500273317069 0.243263428505302 NA NA NA 0.349787089293373 97.2480394260729 a2894 TP53_mut 1043 JNK Inhibitor VIII JNK 34 9 2.30258509299405 NA 4.86600562538574 4.53789439194139 0.328111233444354 0.757634842220926 0.661173409760913 0.443512588491314 0.433073052029301 0.496255942239121 0.24357283611964 NA NA NA 0.220337942508171 97.2480394260729 a2895 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1028 VX-702 p38 15 30 0.693147180559945 NA 3.59588997358668 3.34230216091392 0.253587812672761 0.616195493338413 0.706464413477394 0.373805799085948 0.411537921673002 0.358953413413336 0.243670619710759 NA NA NA 0.224728121639549 97.2480394260729 a2896 loss_cnaBRCA20 1005 Cisplatin DNA crosslinker 3 42 1.79175946922805 2.30258509299405 4.44362524863195 3.61483057322574 0.828794675406213 0.901109737178998 1.1850110449268 0.70636078090103 0.919748884304398 0.699398270551486 0.243713827859263 NA NA NA 0.24623267025875 97.2480394260729 a2897 gain_cnaBRCA8_(CHD4,WNK1) 238 CAL-101 PI3Kdelta 4 45 2.99573227355399 2.32630161961136 4.18814516268159 4.76614813558762 -0.578002972906025 0.874458768783394 0.942899576834871 0.615761386824938 0.660983677606871 0.613005867333473 0.243864828164968 NA NA NA 0.282690658131163 97.2480394260729 a2898 BRCA1_mut 1259 BMN-673 PARP1 4 42 2.30258509299405 NA 2.43376089841857 3.38856443498022 -0.954803536561651 1.48081334950422 1.54960874552913 0.617989631444869 0.644783177354066 0.616157813587726 0.243939812884042 NA NA NA 0.292877870667748 97.2480394260729 a2899 PIK3CA_mut 111 Salubrinal GADD34-PP1C 4 9 2.77258872223978 NA 3.78819322210981 2.99192172329867 0.79627149881114 1.37913968834243 0.938019274106624 0.739750977088186 0.577368272077042 0.848886073870406 0.24398742782919 NA NA NA 0.348512788613565 97.2480394260729 a2900 gain_cnaBRCA15 127 GSK269962A ROCK1, ROCK2 6 8 0.916290731874155 NA 2.06190855093889 2.77269952390875 -0.710790972969857 1.45544761227404 0.682108033395929 0.661653414027733 0.488365893059725 1.04205043507716 0.244025056387629 NA NA NA 0.30612533611202 97.2480394260729 a2901 gain_cnaBRCA15 205 BMS-708163 g-secretase 22 26 2.32630161961136 0.940007258491471 4.77173253023789 5.00212696848109 -0.230394438243197 0.745547674788695 0.607516916036737 0.341807858280539 0.309027103207713 0.379239544054547 0.244090768356085 NA NA NA 0.252917291107634 97.2480394260729 a2902 gain_cnaBRCA48 238 CAL-101 PI3Kdelta 5 44 2.99573227355399 2.32630161961136 5.18820249300894 4.66564168834374 0.522560804665206 0.867820380279148 0.94501680574941 0.556689140802917 0.602153183469967 0.55296456262575 0.244105197028169 NA NA NA 0.260506589009102 97.2480394260729 a2903 loss_cnaBRCA7_(FAS,PTEN) 1032 Afatinib ERBB2, EGFR 4 41 -0.693147180559945 NA 1.31463798344475 0.19055303643908 1.12408494700567 1.25329079811728 1.8528504922965 0.618495539645722 0.896906726431161 0.606678710278688 0.244198309776793 NA NA NA 0.172224309860729 97.2480394260729 a2904 gain_cnaBRCA63 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 5 38 1.6094379124341 NA 2.20431874475238 3.04348394645997 -0.839165201707588 3.28123738030696 1.14277694623345 0.562082390998482 0.255746568884048 0.734321080306567 0.244202693849168 NA NA NA 0.599903878116624 97.2480394260729 a2905 loss_cnaBRCA22_(SYNCRIP,ZNF292) 263 FR-180204 ERK 19 30 2.99573227355399 NA 5.51187026017692 5.26036082119183 0.251509438985083 0.859122893846748 0.632927908418592 0.345523383637162 0.292751410521657 0.397374543987948 0.244543239850413 NA NA NA 0.279647107695702 97.2480394260729 a2906 ARID1A_mut 1268 XAV 939 TNKS1 (tankyrase-1) 5 42 1.6094379124341 NA 3.19698559512789 3.71673519655808 -0.519749601430184 0.878446478109609 0.937357945002939 0.557508463055422 0.591669059392975 0.554483593168407 0.244810274436932 NA NA NA 0.2679707439807 97.2480394260729 a2907 gain_cnaBRCA31 1028 VX-702 p38 14 31 0.693147180559945 NA 3.60429112982885 3.34668834237464 0.25760278745421 0.639893471154702 0.694489408643747 0.379694694315654 0.402571363932437 0.370923997181291 0.24481745448251 NA NA NA 0.234075622404085 97.2480394260729 a2908 loss_cnaBRCA29_(MAP2K4) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 39 2.30258509299405 NA 2.59782146222955 3.26595090375534 -0.668129441525793 2.28065536040662 1.09769114312349 0.517071236284044 0.292955022106747 0.608667971597755 0.244840003471837 NA NA NA 0.510176191749049 97.2480394260729 a2909 loss_cnaBRCA24 1069 EHT 1864 Rac GTPases 3 43 2.30258509299405 NA 4.12211882424032 3.52230328821308 0.59981553602724 0.650500276507421 0.86065235376633 0.703823006071625 0.922083445141161 0.696931267778873 0.244878268650293 NA NA NA 0.245367504794203 97.2480394260729 a2910 loss_cnaBRCA23 275 I-BET BRD2, BRD3, BRD4 3 46 2.99573227355399 NA 3.15020278232554 4.09690225131045 -0.946699468984912 0.769376713734346 1.36971739005621 0.701455272048634 1.23047585413638 0.691164086736216 0.245052262858082 NA NA NA 0.150631304043953 97.2480394260729 a2911 ARID1A_mut 134 Etoposide TOP2 5 42 2.77258872223978 NA 1.41004463352132 2.60413229970233 -1.194087666181 1.90038229938127 2.16524571062086 0.557196410117929 0.628340764155602 0.55147905862315 0.245070518043554 NA NA NA 0.24467048561665 97.2480394260729 a2912 PTEN_mut 1377 Afatinib (rescreen) ERBB2, EGFR 8 39 2.30258509299405 NA 3.58288704637515 2.68115358305451 0.90173346332064 1.01352999498204 2.10291935270986 0.456953066217007 0.889695882494941 0.428800782188175 0.245251496350688 NA NA NA 0.0804331093784737 97.2480394260729 a2913 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1219 PFI-1 BRD2, BRD3, BRD4 15 32 2.30258509299405 NA 3.42089161308855 3.05603861681905 0.364852996269503 1.24198498560876 0.853004925219519 0.368342114607097 0.293766028170357 0.427726717024065 0.245333821257566 NA NA NA 0.315235938719863 97.2480394260729 a2914 gain_cnaBRCA63 156 AZD6482 PI3Kbeta 6 41 1.63315443905142 NA 2.70402748530903 1.95808282389524 0.745944661413792 1.71951865659089 1.41388989893144 0.51407902660702 0.433810158764254 0.527583273618085 0.245734893195646 NA NA NA 0.349675767127991 97.2480394260729 a2915 gain_cnaBRCA12_(TERT) 309 Y-39983 ROCK 9 40 2.99573227355399 NA 4.55419350921267 5.020658096311 -0.466464587098323 1.24756436516674 1.03694941970864 0.433632190758919 0.373900217193184 0.449843143968768 0.24576661605051 NA NA NA 0.319861086981859 97.2480394260729 a2916 gain_cnaBRCA30_(CRNKL1,FOXA2) 154 CHIR-99021 GSK3B 5 42 0.940007258491471 NA 3.72251330268134 3.22221347313422 0.500299829547119 1.23571441085219 0.859458272572898 0.556321028686803 0.40486687308445 0.582110668443982 0.245801632845141 NA NA NA 0.423459307880794 97.2480394260729 a2917 loss_cnaBRCA17 208 SB-715992 KIF11 11 38 -2.05572501506252 NA -1.76902705926599 -1.08673071691734 -0.682296342348653 1.23542997457689 1.80036687682689 0.402297084218352 0.552274395464889 0.378976280407461 0.245914237511329 NA NA NA 0.162564791899565 97.2480394260729 a2918 gain_cnaBRCA58_(CCND1) 206 Ruxolitinib JAK1, JAK2, TYK2 10 39 1.65632149833295 0.0237165266173161 4.58531407924162 4.31511849671278 0.270195582528846 0.328903192707143 0.70359160055008 0.416444757845619 0.821504894205845 0.384023320229523 0.245962815658013 NA NA NA 0.0875785634475442 97.2480394260729 a2919 loss_cnaBRCA42 341 EX-527 SIRT1 3 46 2.99573227355399 NA 5.21473628758871 5.66960217039242 -0.454865882803711 0.391188743768788 0.659096693097469 0.699847633562686 1.16277855651327 0.69013528298259 0.246120024568195 NA NA NA 0.167790421461815 97.2480394260729 a2920 loss_cnaBRCA42 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 46 3.68887945411394 NA 2.67979328808801 3.5103063556735 -0.830513067585497 0.366543979459434 1.2104097289495 0.699799298482735 2.26579377680765 0.686142095293874 0.246152179818677 NA NA NA 0.0254148715066092 97.2480394260729 a2921 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1129 PF-4708671 RPS6KB1 (p70S6KA) 8 35 2.30258509299405 NA 4.23506902461995 3.7115721573411 0.523496867278849 1.16116690391055 1.13032734346565 0.460965950334219 0.450836882721878 0.463137400245293 0.246264597450885 NA NA NA 0.273850757810819 97.2480394260729 a2922 BRCA1_mut 1091 BMS-536924 IGF1R 4 43 1.38629436111989 NA 3.63353453188838 2.96653642266481 0.666998109223565 0.392760111092256 1.11965715790337 0.613932903754077 1.69823281536575 0.595716380246754 0.2463908223441 NA NA NA 0.0308263635525263 97.2480394260729 a2923 MACF1_mut 1052 RO-3306 CDK1 3 40 1.6094379124341 NA 4.30590086744592 3.46715629764294 0.838744569802978 0.609782943521013 1.21386415987547 0.703926203332155 1.37548053568028 0.690970701276019 0.246403798864451 NA NA NA 0.118025359301568 97.2480394260729 a2924 BRCA1_mut 266 Zibotentan, ZD4054 Endothelin A Receptor 4 45 2.99573227355399 NA 6.0169782537401 5.71760037390414 0.29937787983596 0.105208159033765 0.504648764887774 0.612224272521192 2.84557664144546 0.593240092250176 0.246544864223695 NA NA NA 0.00362839899926808 97.2480394260729 a2925 gain_cnaBRCA8_(CHD4,WNK1) 1241 CHIR-99021 GSK3B 3 43 2.30258509299405 NA 3.59549913566922 4.27585834528818 -0.680359209618965 0.921891957159274 0.972576556854958 0.701162600128563 0.738003194772877 0.699543089768745 0.246639123716165 NA NA NA 0.328263705132723 97.2480394260729 a2926 loss_cnaBRCA33 1018 ABT-888 PARP1, PARP2 5 40 1.6094379124341 NA 4.07658945411088 4.44388703426081 -0.367297580149934 0.367469223545994 0.682186107375658 0.557120489354639 0.999532904022809 0.538412577123438 0.246653142568819 NA NA NA 0.0984697050367522 97.2480394260729 a2927 loss_cnaBRCA23 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 3 40 1.6094379124341 NA 3.9229906325949 2.8726252947864 1.0503653378085 0.948377022126273 1.51589588921423 0.703420850085996 1.10753984259717 0.69290070992472 0.24673755589362 NA NA NA 0.182438354944824 97.2480394260729 a2928 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 194 AUY922 HSP90 15 32 -1.36257783450257 NA -2.82251550199909 -2.19276187456937 -0.629753627429714 1.22986697095864 1.8936761060074 0.367221068087631 0.512050199168163 0.332556145917412 0.246751897070355 NA NA NA 0.179920043871849 97.2480394260729 a2929 gain_cnaBRCA31 299 OSI-027 MTORC1/2 16 32 2.99573227355399 NA 1.74079819884721 1.03305524602206 0.707742952825144 1.67754390666401 2.09790109020262 0.359131895686223 0.421892357042726 0.337357636225257 0.246866076761557 NA NA NA 0.214121533884538 97.2480394260729 a2930 loss_cnaBRCA60 1066 AZD6482 PI3Kbeta 3 40 1.6094379124341 NA 2.90056980178951 1.89718397569379 1.00338582609572 0.359607986708125 1.46073027604849 0.703207840416856 2.79022119414192 0.686906982451294 0.246878334988015 NA NA NA 0.00990270096225275 97.2480394260729 a2931 gain_cnaBRCA15 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 20 23 0.693147180559945 NA 2.72629425599229 3.06678776962364 -0.34049351363135 1.20117613442417 0.655101291329832 0.359130105167965 0.283466765508605 0.519757048471329 0.246925002018725 NA NA NA 0.267925778482513 97.2480394260729 a2932 POLR2B_mut 346 THZ-2-102-1 CDK7 3 45 0.916290731874155 2.99573227355399 0.320640105292108 -1.44554415494353 1.76618426023563 3.5715955081907 2.46840896549963 0.699088427332105 0.494508478405593 0.715515250884751 0.247069783970866 NA NA NA 0.483195541682358 97.2480394260729 a2933 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 279 BIX02189 MAP2K5 (MEK5) 6 43 2.99573227355399 NA 4.62675038433085 5.0832545087612 -0.456504124430359 1.21402594870798 0.847562710774522 0.510791287151958 0.376025014058547 0.538608080118574 0.247074135301545 NA NA NA 0.408831463094487 97.2480394260729 a2934 loss_cnaBRCA33 208 SB-715992 KIF11 6 43 -2.05572501506252 NA -2.00007326291332 -1.13382849575128 -0.866244767162043 1.65829717615098 1.70057594296798 0.510718893898523 0.522370042969412 0.509383171474369 0.247140173391583 NA NA NA 0.27355229574425 97.2480394260729 a2935 gain_cnaBRCA63 1011 ABT-263 BCL2, BCL2L1, BCL2L2 5 38 0.693147180559945 NA 2.50014223997033 1.57428975608041 0.925852483889922 1.67883351193141 1.65542882994184 0.558507292156379 0.551485586456262 0.559282566030004 0.247165949741114 NA NA NA 0.297230695219542 97.2480394260729 a2936 loss_cnaBRCA29_(MAP2K4) 1023 GW 441756 NTRK1 6 39 0.693147180559945 NA 2.93520821184952 2.27068349536321 0.664524716486317 0.56230063602569 1.35886224788749 0.514446218381585 1.18179613166213 0.489030229163696 0.247206131310072 NA NA NA 0.0515483106527829 97.2480394260729 a2937 loss_cnaBRCA36_(FAT1,IRF2) 164 JQ12 HDAC 9 38 1.63315443905142 NA 1.00538328924206 1.7134752486389 -0.708091959396834 2.10071598818874 1.50835001090943 0.434552212979792 0.337071723820867 0.46944804208269 0.247280620696022 NA NA NA 0.362191361198706 97.2480394260729 a2938 loss_cnaBRCA57 333 T0901317 LXR 5 43 2.32630161961136 NA 5.11186585535372 4.69166531657342 0.420200538780297 0.160530009446499 0.792810605475983 0.553598860292262 2.61758247089832 0.530013771104916 0.247375017078466 NA NA NA 0.00523346484894351 97.2480394260729 a2939 loss_cnaBRCA33 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 5 38 1.6094379124341 NA 2.20934310040548 3.04282284703193 -0.833479746626448 2.86186365102507 1.25920168916818 0.558145903687148 0.29123670735603 0.661911236139653 0.247466937215438 NA NA NA 0.553557658413124 97.2480394260729 a2940 loss_cnaBRCA17 1527 GDC0941 (rescreen) PI3K 9 36 1.38629436111989 NA 1.38158979895438 0.880422351965923 0.501167446988458 0.99343188391137 1.17967803925249 0.436816105250495 0.504480936342859 0.424834090584603 0.247609877950196 NA NA NA 0.213815133572918 97.2480394260729 a2941 gain_cnaBRCA61_(NOTCH2) 172 Embelin XIAP 3 45 3.46573590279973 NA 3.62209209108891 2.95112685237712 0.670965238711795 0.802142985305625 0.96752646998136 0.698247193755366 0.836465880775795 0.693485149532624 0.247630703918641 NA NA NA 0.280954881676577 97.2480394260729 a2942 ASH1L_mut 1268 XAV 939 TNKS1 (tankyrase-1) 3 44 1.6094379124341 NA 3.05137462393604 3.70303823543797 -0.651663611501923 0.688036736739643 0.942269030687308 0.698877769805363 0.947134908217141 0.69158975863463 0.247674019050934 NA NA NA 0.235865549573141 97.2480394260729 a2943 gain_cnaBRCA64_(SDHC) 153 Midostaurin KIT 8 39 -0.669430653942629 NA 1.15720201603688 0.500385510398843 0.656816505638039 1.16039593340265 1.49149347979022 0.454550311499921 0.566027927822916 0.440375043228764 0.247705055470653 NA NA NA 0.191099250758347 97.2480394260729 a2944 gain_cnaBRCA47_(EGFR) 1004 Vinblastine Microtubules 7 38 -2.30258509299405 NA -3.97377641397986 -3.36009950280009 -0.613676911179761 0.917654017190977 1.32227036148496 0.481862119995652 0.668745409144813 0.464108497819297 0.247832339839312 NA NA NA 0.160036913649992 97.2480394260729 a2945 ARID1A_mut 1219 PFI-1 BRD2, BRD3, BRD4 5 42 2.30258509299405 NA 3.66258695516904 3.11413512282602 0.54845183234302 1.2649007472068 0.959765219875105 0.553599538654459 0.433592780741202 0.571443745809408 0.248084702399285 NA NA NA 0.395200951694894 97.2480394260729 a2946 loss_cnaBRCA20 1495 AZD-2281 PARP1, PARP2 3 42 2.30258509299405 NA 4.73099298230291 3.94638403371621 0.784608948586706 0.2518323490212 1.14699374951761 0.699720310916044 3.11560032551915 0.684056865102089 0.248104493340844 NA NA NA 0.00557825780468277 97.2480394260729 a2947 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1005 Cisplatin DNA crosslinker 15 30 1.79175946922805 2.30258509299405 3.95978820295708 3.52523122590068 0.4345569770564 1.163713041577 1.17845643065442 0.370252742922382 0.373422795423442 0.368750991341345 0.24811008121256 NA NA NA 0.249396326617576 97.2480394260729 a2948 gain_cnaBRCA31 344 THZ-2-49 CDK9 16 33 2.99573227355399 NA 2.13636365177589 1.61505019227192 0.521313459503969 1.48617024562192 1.45296713743389 0.356174623126887 0.350776407373041 0.358792326455964 0.248226177876895 NA NA NA 0.255507159532751 97.2480394260729 a2949 gain_cnaBRCA12_(TERT) 1038 NU-7441 PRKDC (DNAPK) 9 34 0.693147180559945 NA 3.21824992859506 2.80673371519351 0.411516213401544 0.963195100485688 0.930899357166266 0.439049746556961 0.427240766895552 0.44206305465097 0.248270432954596 NA NA NA 0.27300171442498 97.2480394260729 a2950 gain_cnaBRCA58_(CCND1) 1003 Camptothecin TOP1 9 36 -2.30258509299405 NA -1.97925941579126 -2.66678695108893 0.687527535297668 0.991010846521098 1.68188865372873 0.436124556014904 0.693763885341118 0.408783027207792 0.248347593462537 NA NA NA 0.127358054206369 97.2480394260729 a2951 gain_cnaBRCA10_(MDM2,NUP107) 1377 Afatinib (rescreen) ERBB2, EGFR 3 44 2.30258509299405 NA 4.12377853189927 2.74674432987339 1.37703420202588 0.972388620312869 2.00822764567226 0.697667830374469 1.41613566146302 0.685696268046802 0.24848143214486 NA NA NA 0.111007300995433 97.2480394260729 a2952 loss_cnaBRCA57 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 5 43 2.07944154167984 NA 2.64393732399458 3.28062509346995 -0.63668776947537 1.11634060121429 1.15630613862555 0.552255677527032 0.570334688877944 0.550622147723071 0.248507210239156 NA NA NA 0.282472978367512 97.2480394260729 a2953 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1049 PD-173074 FGFR1, FGFR3 4 39 0.693147180559945 NA 3.56968170288636 2.87295191677233 0.696729786114036 0.458010694648769 1.17053000676358 0.614572327848813 1.52120855310667 0.595225907997383 0.248526705555831 NA NA NA 0.0460643628363175 97.2480394260729 a2954 loss_cnaBRCA57 184 BMS-754807 IGF1R 5 43 0.940007258491471 NA 2.45142037069594 1.5309908830501 0.920429487645842 0.69061457863185 1.73126162664223 0.552224799269366 1.33276869056148 0.531652451299927 0.248533282033326 NA NA NA 0.0438798933634657 97.2480394260729 a2955 gain_cnaBRCA27_(CLTC,PPM1D) 1375 Temozolomide DNA akylating agent 10 36 3.40119738166216 NA 6.12679329953898 5.83716277871586 0.28963052082312 0.706326367942316 0.689408616647175 0.41799596567388 0.410051973094078 0.42011444857143 0.248558580769879 NA NA NA 0.268001690838814 97.2480394260729 a2956 MLL3_mut 1033 Vismodegib SMO 3 42 2.30258509299405 NA 4.25319514828312 4.79595881406751 -0.542763665784391 0.183291815811634 0.794163522080477 0.699003933353706 2.96119967703402 0.68344069035368 0.248581563706837 NA NA NA 0.00726201948194948 97.2480394260729 a2957 PIK3CA_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 16 30 1.38629436111989 NA 3.20564597699723 2.67352298635397 0.532122990643265 1.12582947313583 1.62011579770069 0.36189088805726 0.472649724794569 0.328447504430528 0.248692787071634 NA NA NA 0.199806037119636 97.2480394260729 a2958 NF1_mut 208 SB-715992 KIF11 5 44 -2.05572501506252 NA -0.400438620100778 -1.33529254077911 0.934853920678334 1.01540604849095 1.74619135958559 0.55111408786092 0.920670033498095 0.535367395759075 0.248792249485189 NA NA NA 0.117715423110204 97.2480394260729 a2959 gain_cnaBRCA58_(CCND1) 219 AT-7519 CDK9 10 39 2.32630161961136 NA 2.2647763580663 1.52000669446886 0.744769663597449 1.64128285880658 1.83513153077282 0.413846296648717 0.453772888445925 0.405839936325332 0.24887977482894 NA NA NA 0.230515651908489 97.2480394260729 a2960 gain_cnaBRCA48 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 5 40 2.30258509299405 NA 1.90433445276357 1.2979477106517 0.606386742111864 0.668373800004346 1.12861234281535 0.554285048425178 0.907256900416984 0.537285229930426 0.249028625076066 NA NA NA 0.123504435974666 97.2480394260729 a2961 gain_cnaBRCA14_(RAD21) 1030 KU-55933 ATM 19 23 2.30258509299405 NA 4.40389950317561 4.07228184137716 0.331617661798451 0.984288775743808 0.853813376329547 0.362489819515038 0.336910945213059 0.38839595512551 0.24921876814282 NA NA NA 0.256418034413628 97.2480394260729 a2962 gain_cnaBRCA10_(MDM2,NUP107) 165 DMOG Prolyl-4-Hydroxylase 4 42 8.29404964010203 NA 8.42006559914014 7.48902009966549 0.931045499474657 1.48502037309961 1.52661857237569 0.610995047890623 0.626958064912827 0.609874343416237 0.249235805614554 NA NA NA 0.304175329951896 97.2480394260729 a2963 TP53_mut 286 KIN001-236 TIE2 38 11 2.32630161961136 NA 4.60840227102191 4.30416447797361 0.3042377930483 0.711011426478453 0.925702866717035 0.399380253913143 0.42789437935639 0.328655991017145 0.249305951744782 NA NA NA 0.331331409991165 97.2480394260729 a2964 gain_cnaBRCA27_(CLTC,PPM1D) 136 Mitomycin C DNA crosslinker 9 39 2.77258872223978 NA -0.648855428700231 -0.015562945028376 -0.633292483671855 1.84010050143589 1.37726083103305 0.431317977313316 0.344161899405861 0.459820296491579 0.249482756982768 NA NA NA 0.353802629932741 97.2480394260729 a2965 gain_cnaBRCA15 1032 Afatinib ERBB2, EGFR 21 24 -0.693147180559945 NA -0.0477457723726387 0.586411985316946 -0.634157757689585 1.99467010127331 1.64925657579504 0.348803326846239 0.317926135898245 0.384511280413651 0.249513989948 NA NA NA 0.256159519325975 97.2480394260729 a2966 loss_cnaBRCA29_(MAP2K4) 190 Bleomycin DNA damage 7 41 4.15888308335967 NA 0.968511259534594 2.26789221187975 -1.29938095234516 2.5298849233999 2.75235148453371 0.476948272547204 0.513612670808335 0.472098480025816 0.249524541778811 NA NA NA 0.247882298933225 97.2480394260729 a2967 loss_cnaBRCA33 56 WH-4-023 SRC family, ABL 4 8 1.63315443905142 NA 3.76433997917485 2.95275647283309 0.811583506341758 0.707248968836858 1.21042543199809 0.74850374529506 1.14752165376287 0.670494426907445 0.249621256943113 NA NA NA 0.176058755206741 97.2480394260729 a2968 gain_cnaBRCA62 41 S-Trityl-L-cysteine KIF11 4 8 1.63315443905142 NA 0.436024159936374 1.61820669144254 -1.18218253150617 0.712419987115502 1.82963050180725 0.74834478777171 1.65938990046121 0.646131844838861 0.249715193807029 NA NA NA 0.141147318515423 97.2480394260729 a2969 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1058 GDC0941 PI3K (class 1) 8 35 1.38629436111989 0.693147180559945 1.85833478492217 1.22889806317362 0.629436721748557 1.41304350242686 1.36782910909051 0.457554583065409 0.445447518542435 0.460172047491428 0.249720491807027 NA NA NA 0.278938856662543 97.2480394260729 a2970 gain_cnaBRCA10_(MDM2,NUP107) 134 Etoposide TOP2 4 43 2.77258872223978 NA 3.6723178117332 2.36591880251562 1.30639900921758 1.12276365392486 2.19853277453234 0.609419790681145 1.16355655498001 0.594214025076553 0.249828947810358 NA NA NA 0.0972884425211864 97.2480394260729 a2971 loss_cnaBRCA17 299 OSI-027 MTORC1/2 10 38 2.99573227355399 NA 0.622602400924567 1.43906618539515 -0.816463784470581 1.16851822271238 2.12084779599031 0.41422437548457 0.698717203207488 0.384970475492958 0.24983056073289 NA NA NA 0.11768731866154 97.2480394260729 a2972 gain_cnaBRCA31 1004 Vinblastine Microtubules 14 31 -2.30258509299405 NA -3.12601743980056 -3.60438618861467 0.478368748814113 1.47875582131336 1.17381240734185 0.375566015494817 0.323494076519846 0.40753424126552 0.249905540091377 NA NA NA 0.297823181324178 97.2480394260729 a2973 ASH1L_mut 229 LY317615 PRKCB (PKCbeta) 3 46 2.99573227355399 2.32630161961136 4.40298101197134 3.29047016287744 1.11251084909389 1.13359134024782 1.62060667070455 0.69406137351825 0.981403800112557 0.686478014193434 0.249990995151722 NA NA NA 0.22353972755791 97.2480394260729 a2974 gain_cnaBRCA12_(TERT) 308 XL-880 MET 9 40 1.63315443905142 NA 1.28878092200384 1.97349256820129 -0.684711646197454 1.30370239301362 1.64655519783423 0.429713169794514 0.525205483910083 0.415844939239254 0.249999063348147 NA NA NA 0.197357334099623 97.2480394260729 a2975 loss_cnaBRCA33 64 CMK RSK 4 8 1.38629436111989 NA 2.78368566166462 1.91439188306722 0.869293778597405 0.348236604688684 1.37057991164409 0.747802593295246 2.49627341552602 0.634252531510284 0.25003582135294 NA NA NA 0.127239796381237 97.2480394260729 a2976 POLR2B_mut 231 FMK RSK 3 46 2.99573227355399 2.32630161961136 5.20530061088581 5.6142685508337 -0.408967939947884 0.34726892299453 0.597861979719101 0.693903441443602 1.17766927262399 0.684050757233356 0.250097262735606 NA NA NA 0.163732765043863 97.2480394260729 a2977 gain_cnaBRCA12_(TERT) 175 PAC-1 CASP3 agonist 9 39 0.940007258491471 NA 2.82631066263437 2.3033212939082 0.522989368726167 1.10715554333978 1.23549263151624 0.430745985321402 0.472372081657605 0.423304320386221 0.250102117253195 NA NA NA 0.233643867637133 97.2480394260729 a2978 gain_cnaBRCA13_(FGFR1,WHSC1L1) 262 VX-11e ERK 11 38 1.63315443905142 NA 4.18543399099918 3.65852661538362 0.526907375615556 0.828758198397351 1.42584349943744 0.39869129806528 0.635779382495989 0.369540819748764 0.250111979800367 NA NA NA 0.132686212442201 97.2480394260729 a2979 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1243 piperlongumine Increases ROS levels 8 39 2.30258509299405 NA 1.39238232055359 1.77545021926819 -0.3830678987146 0.429446046165944 0.903653280887503 0.451998725549235 0.892004716621788 0.423910261619787 0.250329982788921 NA NA NA 0.0813154913589513 97.2814452946172 a2980 loss_cnaBRCA38 300 CX-5461 RNA Pol I 4 45 2.32630161961136 NA 2.96634502679514 3.99645598357293 -1.03011095677779 2.32009856377723 1.64530170937066 0.607228988227419 0.44399448060548 0.62609243697426 0.250365927090387 NA NA NA 0.443985082689621 97.2814452946172 a2981 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 17 Cyclopamine SMO 4 9 2.77258872223978 NA 5.09868525188302 4.51650923330497 0.582176018578051 0.535179822489218 0.877310846675852 0.728930031448505 1.0878138414678 0.66359149756774 0.250531074228464 NA NA NA 0.17452842767228 97.3129590235285 a2982 loss_cnaBRCA7_(FAS,PTEN) 238 CAL-101 PI3Kdelta 4 45 2.99573227355399 2.32630161961136 5.24205923764213 4.67246688448001 0.569592353162116 0.645964076891434 0.955799342517578 0.606541742044277 0.881770942903139 0.595932982818138 0.250894947616743 NA NA NA 0.177421971957318 97.3130109272077 a2983 NF1_mut 269 NSC-207895 MDM4 5 44 2.99573227355399 NA 5.18503105018843 4.53790959827982 0.647121451908612 0.58042552706945 1.22082052193994 0.548441142083015 1.11490866912058 0.53007091564967 0.251062344222756 NA NA NA 0.0731207101980424 97.3130109272077 a2984 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1036 PLX4720 BRAF 6 37 2.30258509299405 NA 5.12234007724282 4.51136307417685 0.610977003065974 0.875440632292173 1.23062285777405 0.512142211450213 0.697907979740726 0.49647786013914 0.251282051270775 NA NA NA 0.172569396953613 97.3130109272077 a2985 gain_cnaBRCA31 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 16 32 0.246860077931526 2.32630161961136 0.124463660406189 -0.45965963724816 0.584123297654349 1.61128415797717 1.65665754320172 0.355738991620728 0.362520350468577 0.352591457450797 0.251294031684763 NA NA NA 0.249816157944681 97.3130109272077 a2986 gain_cnaBRCA16 1018 ABT-888 PARP1, PARP2 15 30 1.6094379124341 NA 4.5647130578763 4.32225775909475 0.242455298781548 0.807112745372152 0.574803759383408 0.367643039977102 0.300398302680445 0.421805346300501 0.251407963534045 NA NA NA 0.310382153924532 97.3130109272077 a2987 gain_cnaBRCA31 178 BAY 61-3606 SYK 16 32 2.07944154167984 NA 3.47386156628264 2.90669844934921 0.567163116933436 1.90202870904845 1.42370646557247 0.355473220560788 0.298188515365352 0.398370823374311 0.251643282143492 NA NA NA 0.302429717266858 97.3130109272077 a2988 BRCA2_mut 326 GSK690693 AKT 6 42 2.32630161961136 NA 2.08988501637176 3.06096299824332 -0.971077981871559 1.42095560375951 1.96844626390119 0.50668615621209 0.683397834036698 0.493322068110214 0.251646037519605 NA NA NA 0.176162904025527 97.3130109272077 a2989 BRCA2_mut 1019 Bosutinib SRC, ABL, TEC 5 40 0.693147180559945 NA 3.11684879378329 2.60581725525082 0.511031538532474 0.634622050441155 0.952172498854682 0.551136635359339 0.805253360133377 0.536700586445383 0.251685659626001 NA NA NA 0.158884502488312 97.3130109272077 a2990 gain_cnaBRCA14_(RAD21) 1129 PF-4708671 RPS6KB1 (p70S6KA) 20 23 2.30258509299405 NA 4.02492997213362 3.62117296787937 0.403757004254249 1.14353000543495 1.12962047572946 0.355392515055723 0.35307950148687 0.357427129668058 0.251797505313167 NA NA NA 0.252367024170411 97.3130109272077 a2991 CDH1_mut 172 Embelin XIAP 4 44 3.46573590279973 NA 3.52694820178658 2.94452708688842 0.582421114898158 1.69271450321508 0.887931145190173 0.605943146606443 0.344075219886122 0.655930494220267 0.251916280387185 NA NA NA 0.543276162440362 97.3130109272077 a2992 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 38 -1.38629436111989 0.693147180559945 0.627800484894462 -0.400136658677088 1.02793714357155 1.74599590118518 1.67717857376053 0.610980873550439 0.588739723199686 0.612896658503534 0.251994696145996 NA NA NA 0.330123163456929 97.3130109272077 a2993 loss_cnaBRCA28_(GPS2) 1022 AZD7762 CHEK1, CHEK2 3 42 0.693147180559945 NA 1.94768566049922 0.830255330269788 1.11743033022943 2.12043284111296 1.58179519925204 0.693691218115573 0.52698218428032 0.706431737027534 0.252140291538862 NA NA NA 0.459016323139836 97.3130109272077 a2994 BRCA2_mut 1239 YK 4-279 RNA helicase A 4 38 2.30258509299405 NA 1.30401078470016 2.0882415217756 -0.784230737075439 0.612229265846467 1.32401333148199 0.610588062295769 1.28094290950166 0.59231332376211 0.252294725977196 NA NA NA 0.0768907248162702 97.3130109272077 a2995 gain_cnaBRCA10_(MDM2,NUP107) 135 Gemcitabine DNA replication 4 43 0.0237165266173161 NA 1.24553836481552 -0.416689971088205 1.66222833590373 1.44661674297935 2.81405132205729 0.605730674902478 1.1490454150837 0.59068870666101 0.252664974353904 NA NA NA 0.100466158113256 97.3130109272077 a2996 POLR2B_mut 1009 ATRA Retinoic acid and retinoid X receptor agonist 3 42 2.30258509299405 NA 3.36312098306855 4.15903157790848 -0.795910594839922 1.07602429722615 1.15238250436262 0.692732583978599 0.73967715867725 0.690665288501703 0.25278633063096 NA NA NA 0.327401421886829 97.3130109272077 a2997 gain_cnaBRCA19 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 4 44 2.77258872223978 NA -1.21175773278211 -0.366051698698115 -0.845706034083996 0.774923568428642 1.43170631236852 0.604806741121549 1.09134122194642 0.590697985178898 0.252794057916803 NA NA NA 0.11354086396781 97.3130109272077 a2998 loss_cnaBRCA7_(FAS,PTEN) 185 OSI-906 IGF1R 4 44 0.940007258491471 NA 3.51455319943518 2.83702961379317 0.677523585642003 0.41888998247235 1.15337191897418 0.604798265142907 1.6174260879746 0.587428542776212 0.252800613156009 NA NA NA 0.0366152050459618 97.3130109272077 a2999 loss_cnaBRCA60 197 Bryostatin 1 PRKC 3 45 -4.8283137373023 NA -2.18543435506557 -2.8482285609589 0.662794205893327 0.167586674667684 0.98078257119375 0.690510920359896 3.95493381086303 0.675780978740898 0.252832316076265 NA NA NA 0.00143750310239177 97.3130109272077 a3000 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 6 42 2.77258872223978 NA -1.05481174924951 -0.348200837579725 -0.706610911669789 1.51987349645027 1.38276198310783 0.50532962519184 0.464914292748779 0.511014129909506 0.252899531899251 NA NA NA 0.321371967065629 97.3130109272077 a3001 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1001 AICAR AAPK1 (AMPK) agonist 15 30 7.60090245954208 NA 8.07331847236214 7.57106570736852 0.502252764993621 1.36669316654537 1.37267117832546 0.366413227711282 0.367494897382989 0.365894449394884 0.252973005796835 NA NA NA 0.255598851569465 97.3130109272077 a3002 gain_cnaBRCA16 192 LFM-A13 BTK 16 32 2.77258872223978 NA 4.99180974958928 4.69730031159838 0.294509437990901 1.01839623897231 0.72327989385794 0.35435733396253 0.289189439945396 0.40718598773706 0.253113487680401 NA NA NA 0.312097015547671 97.3130109272077 a3003 gain_cnaBRCA63 283 GSK2126458 PI3K, MTOR 7 41 -2.05572501506252 0.0237165266173161 -3.71135399116646 -2.94335857205304 -0.767995419113416 0.951257557024246 1.70103075292226 0.473195669112437 0.807347509034129 0.451488262510276 0.25321550522349 NA NA NA 0.108267212672662 97.3130109272077 a3004 gain_cnaBRCA15 341 EX-527 SIRT1 22 27 2.99573227355399 NA 5.76078275250364 5.5447662276199 0.216016524883743 0.598171748616398 0.689410955441638 0.332216256865741 0.361127929199934 0.313334917553439 0.253245432791974 NA NA NA 0.246412844258534 97.3130109272077 a3005 loss_cnaBRCA20 1502 Bicalutamide ANDR (androgen receptor) 3 42 2.30258509299405 NA 4.93243300550002 4.53157957062387 0.400853434876151 0.467209136973752 0.584192884581762 0.691990557412707 0.857974305623803 0.686166239705455 0.253287213474937 NA NA NA 0.271439076206722 97.3130109272077 a3006 gain_cnaBRCA63 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 3 11 1.38629436111989 NA 1.44060490473418 2.05148696366118 -0.610882058926993 0.951027845656019 0.743428145619246 0.781313587533189 0.642338772431639 0.821709619855935 0.253463145187478 NA NA NA 0.386091244503298 97.3130109272077 a3007 loss_cnaBRCA38 205 BMS-708163 g-secretase 4 44 2.32630161961136 0.940007258491471 4.52318182433409 4.93047021700922 -0.407288392675128 0.756006489534235 0.668376472039666 0.603892448766318 0.53873663561546 0.609369733545852 0.253501867921634 NA NA NA 0.36538114644236 97.3130109272077 a3008 BRCA1_mut 1069 EHT 1864 Rac GTPases 4 42 2.30258509299405 NA 4.03276813957546 3.51653155494242 0.516236584633037 0.391189907004484 0.876984800201171 0.605414042411973 1.31965721862839 0.588649409333682 0.253520752525352 NA NA NA 0.0698526791062767 97.3130109272077 a3009 ARID1A_mut 263 FR-180204 ERK 5 44 2.99573227355399 NA 5.00110329478374 5.39842825239086 -0.397324957607115 0.52317865026967 0.744517714529993 0.545548306999849 0.759444135196104 0.533667567410323 0.253535956998385 NA NA NA 0.176434207957233 97.3130109272077 a3010 gain_cnaBRCA27_(CLTC,PPM1D) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 9 39 2.32630161961136 NA 4.7183853959017 5.01389925137921 -0.295513855477508 0.930423033860174 0.629308575654015 0.427559131569543 0.317612359886953 0.469584980898111 0.253573192110751 NA NA NA 0.386663813023733 97.3130109272077 a3011 gain_cnaBRCA58_(CCND1) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 8 35 1.6094379124341 NA 2.39411455391839 3.07203049308268 -0.677915939164288 0.834959378533442 1.5961787823069 0.453780387111244 0.81191487465535 0.424711784593778 0.253584736966775 NA NA NA 0.105105386920524 97.3130109272077 a3012 loss_cnaBRCA17 1166 QL-VIII-58 MTOR, ATR 4 22 2.30258509299405 NA -0.923390008152035 -1.62732472175157 0.703934713599536 0.585194153442181 1.16272443683166 0.635817622220312 1.20290797414654 0.605418353051652 0.253593830179464 NA NA NA 0.102635100119238 97.3130109272077 a3013 loss_cnaBRCA36_(FAT1,IRF2) 1199 Tamoxifen ER 9 38 1.6094379124341 NA 3.54110454400472 3.9468699882038 -0.405765444199075 0.85257360525093 0.965653560905269 0.428683589046989 0.475930103512471 0.420197740293821 0.253627639224411 NA NA NA 0.232648397292343 97.3130109272077 a3014 loss_cnaBRCA17 1259 BMN-673 PARP1 9 37 2.30258509299405 NA 3.84012558519691 3.17550323232625 0.664622352870658 1.15158133828214 1.62064716016679 0.429902295833364 0.577138870504885 0.410096885494965 0.253644867655726 NA NA NA 0.173324711511895 97.3130109272077 a3015 MLL3_mut 1264 SGC0946 Q8TEK3 (DOT1L) 3 43 -0.693147180559945 NA 1.5616199532439 1.9778597361172 -0.416239782873291 0.774517518487653 0.593252634898405 0.690652837337814 0.537418164131463 0.701623150724939 0.253684959172964 NA NA NA 0.451444381143872 97.3130109272077 a3016 TP53_mut 329 QL-XI-92 DDR1 37 11 2.32630161961136 NA 4.3388666901448 3.96563792526272 0.373228764882076 0.939201109202417 0.944183828125862 0.396930874815327 0.397389612538925 0.395292477761358 0.253721543289374 NA NA NA 0.265705491937524 97.3130109272077 a3017 loss_cnaBRCA22_(SYNCRIP,ZNF292) 172 Embelin XIAP 18 30 3.46573590279973 NA 3.19989336136587 2.86896347085504 0.33092989051083 1.0863785895146 0.879772980039679 0.344247463580038 0.304617463658495 0.376153732859475 0.25420062793786 NA NA NA 0.28223591839278 97.3130109272077 a3018 gain_cnaBRCA14_(RAD21) 1025 SB 216763 GSK3A, GSK3B 16 23 2.30258509299405 NA 5.06261973932899 4.76849461596815 0.294125123360847 0.750458457415951 0.799724295344874 0.377022236187571 0.39192725520558 0.367783153610468 0.254230743715352 NA NA NA 0.249505582673658 97.3130109272077 a3019 loss_cnaBRCA18 277 ABT-869 VEGFR and PDGFR family 15 33 0.0237165266173161 NA 2.57438458511159 2.74412082193067 -0.169736236819079 0.334379899745738 0.521229241643312 0.359417261364768 0.507614952179082 0.325646036826217 0.254379708342539 NA NA NA 0.182872871919107 97.3130109272077 a3020 gain_cnaBRCA31 288 KIN001-055 JAK3, MNK1 16 33 2.32630161961136 NA 4.54014586641477 4.24148510996968 0.298660756445085 0.710910310220291 0.90740820061478 0.351511216792492 0.420110317928205 0.329136056124178 0.254386043974643 NA NA NA 0.216933227331705 97.3130109272077 a3021 gain_cnaBRCA48 1495 AZD-2281 PARP1, PARP2 5 40 2.30258509299405 NA 3.45233976013246 4.06698523905818 -0.614645478925722 0.957502875380238 1.13728897184148 0.547919383840256 0.641925465426553 0.540447937282378 0.254421870701549 NA NA NA 0.237880508106254 97.3130109272077 a3022 gain_cnaBRCA10_(MDM2,NUP107) 1018 ABT-888 PARP1, PARP2 3 42 1.6094379124341 NA 4.82781617973656 4.37273762147089 0.455078558265675 0.237993678163602 0.673474949617753 0.689903672470094 1.91214557368555 0.675717127302159 0.254699737449944 NA NA NA 0.0471577911322044 97.3130109272077 a3023 ARID1A_mut 1243 piperlongumine Increases ROS levels 5 42 2.30258509299405 NA 1.29679515149948 1.75946765139026 -0.46267249989078 0.851437075000519 0.847366432674651 0.545778742565978 0.543401871348506 0.546012305951733 0.254730854143148 NA NA NA 0.302529808771393 97.3130109272077 a3024 TP53_mut 151 QS11 ARFGAP 38 10 2.32630161961136 NA 3.88601672842121 3.28329591722624 0.60272081119497 1.35628828331887 1.86980168511953 0.409754153317711 0.444389897492955 0.322344779123696 0.254904215274191 NA NA NA 0.358870386446455 97.3130109272077 a3025 loss_cnaBRCA22_(SYNCRIP,ZNF292) 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 4 10 1.38629436111989 NA 1.52546586924485 2.07863078374961 -0.553164914504765 0.638483064825592 0.824496490403596 0.707234978257398 0.866373667492445 0.670912394343834 0.255003141598639 NA NA NA 0.220035320470011 97.3130109272077 a3026 gain_cnaBRCA61_(NOTCH2) 266 Zibotentan, ZD4054 Endothelin A Receptor 3 46 2.99573227355399 NA 5.42671239046152 5.76260418846222 -0.335891798000698 0.903205713363747 0.462328332072536 0.686543792443867 0.371888477930192 0.726522202294967 0.255085505218833 NA NA NA 0.586491235031063 97.3130109272077 a3027 ARID1A_mut 158 PF-562271 FAK 5 40 0.940007258491471 NA 1.71109798928153 2.41101923258775 -0.699921243306219 1.05230697213988 1.30079562620803 0.546934200024682 0.665130291670421 0.538071645694697 0.255264020100353 NA NA NA 0.224728156045795 97.3130109272077 a3028 gain_cnaBRCA16 167 OSU-03012 PDPK1 (PDK1) 16 32 2.77258872223978 NA 2.52456627905365 2.10968540184964 0.414880877204007 1.18838533327242 1.17025478114457 0.352730585452978 0.349113091173518 0.354521839080404 0.255267820005482 NA NA NA 0.260948192877401 97.3130109272077 a3029 gain_cnaBRCA27_(CLTC,PPM1D) 1527 GDC0941 (rescreen) PI3K 9 36 1.38629436111989 NA 0.586052077326792 1.07930678237282 -0.493254705046028 1.45786928267207 1.06444158577544 0.429704389008258 0.338339459448628 0.463392929811828 0.255272409703195 NA NA NA 0.362332436754858 97.3130109272077 a3030 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1495 AZD-2281 PARP1, PARP2 14 31 2.30258509299405 NA 4.28560142613169 3.86911898055309 0.416482445578606 1.07133691577137 1.14303853631518 0.371247856945036 0.388750204951852 0.364364308242154 0.255308489355022 NA NA NA 0.247566364600258 97.3130109272077 a3031 gain_cnaBRCA61_(NOTCH2) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 3 43 1.63315443905142 NA 2.95366937564056 1.86563629462595 1.08803308101461 0.91144567132629 1.60606082904129 0.68814009612996 1.19374430670274 0.67745446582126 0.255390790873181 NA NA NA 0.158983197449448 97.3130109272077 a3032 PTEN_mut 290 KIN001-260 IKK 9 40 2.99573227355399 NA 4.68514327696464 5.12483296557214 -0.439689688607495 1.70832804487178 0.832298309645058 0.424755150659832 0.257380126684332 0.528283769788028 0.255428564258433 NA NA NA 0.471350353957261 97.3130109272077 a3033 gain_cnaBRCA61_(NOTCH2) 173 FH535 unknown 3 45 3.46573590279973 NA 2.39156353446494 1.51842703924609 0.873136495218851 0.871693574957078 1.28689271848129 0.686610185469174 1.00165530675369 0.678484292186585 0.255484662080219 NA NA NA 0.216321314328905 97.3130109272077 a3034 gain_cnaBRCA62 1007 Docetaxel Microtubules 8 37 -4.38202663467388 NA -4.02125179831306 -4.70966405708696 0.688412258773894 2.21909286925034 1.35925204122789 0.449219609231073 0.310222374337337 0.506464024252642 0.255636466719079 NA NA NA 0.422751803593469 97.3130109272077 a3035 ARID1A_mut 1218 JQ1 BRD2, BRD3, BRD4 5 41 0 NA 2.11899865552627 2.49932128865135 -0.38032263312508 0.662785211049665 0.700553005702425 0.545496827061073 0.573824863295843 0.542889160462228 0.255717067599511 NA NA NA 0.281044304642236 97.3130109272077 a3036 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 200 LAQ824 HDAC 7 41 0.0237165266173161 NA -2.12108392601556 -2.78065483396026 0.659570907944693 1.23479480569042 1.42475554693435 0.470638313652598 0.534154261829683 0.462936192362188 0.255753256653106 NA NA NA 0.234120357155389 97.3130109272077 a3037 loss_cnaBRCA17 1031 Elesclomol HSP70 8 36 -1.6094379124341 NA -2.32455509985338 -3.12269550850793 0.798140408654551 0.962203780595072 1.8931800772088 0.45033912892177 0.829492073041891 0.421587158170017 0.255774883505419 NA NA NA 0.100037646636709 97.3130109272077 a3038 loss_cnaBRCA42 165 DMOG Prolyl-4-Hydroxylase 3 43 8.29404964010203 NA 6.59017022299232 7.63833943984963 -1.04816921685731 1.40473800126602 1.5299180174377 0.687571588532194 0.746167054577188 0.685114630268085 0.255777876705225 NA NA NA 0.324048048605346 97.3130109272077 a3039 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 295 NVP-BHG712 EPHB4 7 42 2.32630161961136 NA 4.3780834614058 3.80481238412453 0.573271077281264 1.51446465878549 1.17194649108109 0.469496436526754 0.378530508424669 0.489161477630635 0.255950981989546 NA NA NA 0.370353299601557 97.3130109272077 a3040 gain_cnaBRCA14_(RAD21) 255 CP724714 ERBB2 21 27 2.32630161961136 NA 3.49106359912626 4.04568064106995 -0.554617041943691 2.09228942322116 1.22215391632444 0.334593932757302 0.265076636046764 0.453802941295372 0.256097179054339 NA NA NA 0.28869990485967 97.3130109272077 a3041 loss_cnaBRCA24 1175 AG-014699 PARP1, PARP2 3 40 1.6094379124341 NA 4.51465133063527 3.8125895973968 0.702061733238466 0.603053850909546 1.03568808287146 0.689069295891816 1.16417751446176 0.67786985758491 0.256353361827392 NA NA NA 0.166311880042973 97.3130109272077 a3042 gain_cnaBRCA8_(CHD4,WNK1) 1043 JNK Inhibitor VIII JNK 3 40 2.30258509299405 NA 4.32274172607446 4.83292539030911 -0.510183664234652 0.127629932608242 0.75865443422628 0.689012716399489 3.99736687004804 0.672484917003045 0.25639179806161 NA NA NA 0.0017367827900457 97.3130109272077 a3043 loss_cnaBRCA34 346 THZ-2-102-1 CDK7 5 43 0.916290731874155 2.99573227355399 -2.56468041381527 -1.19218987412805 -1.37249053968722 1.894038060375 2.58011047303366 0.542946776222131 0.724637254340854 0.531950299815444 0.25645679957849 NA NA NA 0.193011799296139 97.3130109272077 a3044 gain_cnaBRCA64_(SDHC) 179 5-Fluorouracil DNA antimetabolite 8 41 3.46573590279973 NA 3.44460806934457 4.15793885755823 -0.713330788213654 1.84157705138199 1.56340286229369 0.443645116923727 0.387347783074481 0.45626805823236 0.256851007561793 NA NA NA 0.331536248927401 97.3130109272077 a3045 gain_cnaBRCA31 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 16 31 2.32630161961136 NA 1.77190948767207 1.23372429589971 0.538185191772365 1.81722452397241 1.35112750285524 0.353503638891948 0.29615778604831 0.398323023278749 0.256879574247318 NA NA NA 0.306558581692494 97.3130109272077 a3046 gain_cnaBRCA16 38 AZD-0530 SRC, ABL1 3 11 0.693147180559945 NA 2.19844806467826 2.69230868959772 -0.493860624919461 0.30859315572625 0.684040040486236 0.775264398849727 1.60036156264451 0.721976193920476 0.256958086614335 NA NA NA 0.107287637694891 97.3130109272077 a3047 PTEN_mut 1243 piperlongumine Increases ROS levels 8 39 2.30258509299405 NA 1.39674970863824 1.77455434478929 -0.377804636151056 0.893278475130451 0.839208870720189 0.445605153008459 0.422941609665321 0.450191423533015 0.256995350236269 NA NA NA 0.297552577389411 97.3130109272077 a3048 gain_cnaBRCA16 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 16 30 1.38629436111989 NA 3.19968343298661 2.67670300982629 0.522980423160318 1.3401083350732 1.53458028792105 0.355485111264086 0.390252347122185 0.34079704221199 0.257041118293511 NA NA NA 0.239271075611999 97.3130109272077 a3049 gain_cnaBRCA62 263 FR-180204 ERK 10 39 2.99573227355399 NA 5.12220296299032 5.41831615254393 -0.296113189553615 1.17000448123986 0.576303102070272 0.406490262532779 0.253087226845338 0.513815019370671 0.257272592807882 NA NA NA 0.45515240774054 97.3130109272077 a3050 loss_cnaBRCA33 1017 Olaparib PARP1, PARP2 5 40 1.6094379124341 NA 3.64657304795069 4.12753872905118 -0.48096568110049 0.597739474054189 0.907430806579045 0.544562317196194 0.804640988219036 0.530030144021337 0.257299763506969 NA NA NA 0.159628908522046 97.3130109272077 a3051 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1008 Methotrexate Dihydrofolate reductase (DHFR) 8 37 -1.6094379124341 NA 1.08086427497563 0.596549706766994 0.484314568208634 1.03643047758681 1.0906221849575 0.44761660658487 0.467290936229795 0.444071810466157 0.25731113629738 NA NA NA 0.260991056233346 97.3130109272077 a3052 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1175 AG-014699 PARP1, PARP2 5 38 1.6094379124341 NA 4.35358686935102 3.79683167213218 0.556755197218842 0.356229578153527 1.06617449723437 0.546414294689691 1.56291119930219 0.522198944603392 0.257382655081399 NA NA NA 0.0304100805102389 97.3130109272077 a3053 loss_cnaBRCA34 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 5 40 -0.669430653942629 NA -4.65420667262807 -3.34018959242371 -1.31401708020435 1.17438094389808 2.50680694227503 0.544312498657581 1.11890190915631 0.52417960794852 0.257514855142683 NA NA NA 0.0751340187878831 97.3130109272077 a3054 gain_cnaBRCA15 1164 XMD8-92 MAP2K5 (ERK5) 14 12 2.30258509299405 NA 4.15523284044064 3.56862115743691 0.586611683003736 1.30552339398726 1.2617256457302 0.456281792257317 0.449330655969433 0.464928080830316 0.257519571147679 NA NA NA 0.256435719613158 97.3130109272077 a3055 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 292 Masitinib KIT 5 43 2.99573227355399 NA 3.48505973009723 4.0714050152617 -0.586345285164466 1.10734987420857 1.08002858942405 0.541692625275192 0.529503184875089 0.542897929653091 0.257541608575152 NA NA NA 0.312955858979254 97.3130109272077 a3056 gain_cnaBRCA48 1218 JQ1 BRD2, BRD3, BRD4 5 41 0 NA 2.12038777714436 2.49915188357597 -0.378764106431615 0.866015068874555 0.678112479917991 0.543194485445134 0.437364337001485 0.558556460245978 0.257699464357359 NA NA NA 0.39219377981155 97.3130109272077 a3057 loss_cnaBRCA18 177 GSK-650394 SGK3 16 31 2.77258872223978 NA 3.62239185868468 4.21678562545233 -0.594393766767654 0.950579038192148 1.95072848704409 0.352826188868341 0.625296522315595 0.304703484219031 0.257779312583172 NA NA NA 0.167189184334736 97.3130109272077 a3058 gain_cnaBRCA12_(TERT) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 10 37 -2.30258509299405 NA -0.471891698267193 -0.0510690896196474 -0.420822608647546 1.13801892792635 1.00154506459028 0.408451803729658 0.369785245500575 0.420173413584439 0.257844103497937 NA NA NA 0.306948296575223 97.3130109272077 a3059 gain_cnaBRCA62 9 MG-132 Proteasome 5 9 0 NA 0.988241036246319 -0.0370385536851802 1.0252795899315 1.71896946426868 1.4541737863416 0.662547150623438 0.59645014716285 0.705059876310168 0.257874807006211 NA NA NA 0.295242252628682 97.3130109272077 a3060 loss_cnaBRCA20 171 AKT inhibitor VIII AKT1, AKT2, AKT3 3 44 0.940007258491471 NA 2.68562469253608 1.83432011150146 0.851304581034614 1.25125668488736 1.24471983123669 0.683772690874907 0.680359666658843 0.68393268884356 0.257890520842836 NA NA NA 0.359696328595751 97.3130109272077 a3061 ARID1A_mut 221 TAK-715 p38a 5 44 2.99573227355399 2.32630161961136 4.96753144897477 4.4269960394548 0.540535409519967 0.611494000003148 1.02897904563487 0.540397405438972 0.883958648027918 0.525312358704506 0.257983664379878 NA NA NA 0.129742833037818 97.3130109272077 a3062 PIK3CA_mut 86 A-443654 AKT1, AKT2, AKT3 4 8 0.0237165266173161 NA -1.86838770041035 -0.978500555307994 -0.88988714510236 1.60890770104727 0.994236671357857 0.734333858509882 0.553100183760146 0.895045586969767 0.258107560884196 NA NA NA 0.365660137740043 97.3130109272077 a3063 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 299 OSI-027 MTORC1/2 5 43 2.99573227355399 NA 0.313227831621933 1.38010232316632 -1.06687449154438 2.04693445098325 1.9647734099339 0.5409966625753 0.521205987339706 0.543001287654984 0.25814501548792 NA NA NA 0.319431736849569 97.3130109272077 a3064 BRCA2_mut 201 Epothilone B Microtubules 6 42 -3.44201937618241 NA -5.01956894002281 -4.12378492259453 -0.895784017428277 1.61676924331904 1.81317771924102 0.499636474704705 0.554058051963766 0.494040935933872 0.258209235078695 NA NA NA 0.25201054697479 97.3130109272077 a3065 TP53_mut 344 THZ-2-49 CDK9 38 11 2.99573227355399 NA 1.65645829905946 2.23027812810257 -0.573819829043112 1.55764791712496 1.05042133696854 0.391815733273785 0.368388660065263 0.546275869356505 0.258258930411775 NA NA NA 0.16947212117243 97.3130109272077 a3066 loss_cnaBRCA60 165 DMOG Prolyl-4-Hydroxylase 3 43 8.29404964010203 NA 6.59532462883891 7.6379798301394 -1.04265520130049 1.41171093079792 1.52986396031002 0.683846436975498 0.738575567103647 0.681534586310016 0.258324695873719 NA NA NA 0.327973757557004 97.3130109272077 a3067 gain_cnaBRCA27_(CLTC,PPM1D) 309 Y-39983 ROCK 9 40 2.99573227355399 NA 5.30588315454431 4.85152792611138 0.454355228432938 1.08283551811362 1.07522561574694 0.422057404870602 0.419597640484178 0.422567340080814 0.258418151393051 NA NA NA 0.277335882697318 97.3130109272077 a3068 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 6 42 2.32630161961136 NA 5.26058372624199 4.91533421451078 0.345249511731213 0.439905640282556 0.716015871504571 0.499372847450992 0.784826290268648 0.482181367021567 0.258457026396221 NA NA NA 0.134753199348179 97.3130109272077 a3069 loss_cnaBRCA42 344 THZ-2-49 CDK9 3 46 2.99573227355399 NA 0.848156886814222 1.84639139375967 -0.998234506945451 0.889939748880388 1.48491841544646 0.681606247081044 1.12168774144689 0.672248721924106 0.258471866888927 NA NA NA 0.178785448354114 97.3130109272077 a3070 loss_cnaBRCA57 231 FMK RSK 5 44 2.99573227355399 2.32630161961136 5.87504130962496 5.55675110506552 0.318290204559443 0.395343259215617 0.604574571258624 0.539781298039015 0.805098347170377 0.526469718858363 0.258519378901642 NA NA NA 0.157837052453107 97.3130109272077 a3071 gain_cnaBRCA27_(CLTC,PPM1D) 133 Doxorubicin DNA intercalating 9 39 0.0237165266173161 NA -1.65738604529666 -0.886012430819469 -0.771373614477193 2.05090651827909 1.77165630347582 0.423065394464879 0.376113493034509 0.435396872950941 0.258526366392056 NA NA NA 0.319847947914155 97.3130109272077 a3072 TP53_mut 341 EX-527 SIRT1 38 11 2.99573227355399 NA 5.69893046300696 5.44423191877752 0.254698544229443 0.666854636795521 0.585664803298361 0.391585162408504 0.38194012634202 0.434887913350821 0.258535391175498 NA NA NA 0.234372914071511 97.3130109272077 a3073 loss_cnaBRCA57 1006 Cytarabine DNA synthesis 5 40 0.693147180559945 NA 1.94081880525871 1.11699758348588 0.823821221772826 1.36455623864957 1.53274696276327 0.542741879308391 0.603728302607826 0.537480250678573 0.258870103215148 NA NA NA 0.26164754696575 97.3130109272077 a3074 loss_cnaBRCA18 1025 SB 216763 GSK3A, GSK3B 13 26 2.30258509299405 NA 5.09159475375753 4.78794462298782 0.303650130769707 0.467882096038114 0.892375501568182 0.389083236925037 0.64898856643784 0.340271702031375 0.259386013196188 NA NA NA 0.171753732996195 97.3130109272077 a3075 gain_cnaBRCA19 1050 ZM-447439 AURKB 3 36 1.38629436111989 0.693147180559945 2.05796680919598 2.95708718758933 -0.899120378393353 1.82483768214289 1.27051272025292 0.688188519337423 0.492712522977673 0.707683098374935 0.25947395570026 NA NA NA 0.484973994529743 97.3130109272077 a3076 loss_cnaBRCA18 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 16 32 2.77258872223978 NA -0.762420137201754 -0.273580733706796 -0.488839403494958 1.30766206954513 1.44094509083029 0.349450747311964 0.373827011488528 0.339249154326405 0.259651328486164 NA NA NA 0.246654525963813 97.3130109272077 a3077 ASH1L_mut 175 PAC-1 CASP3 agonist 3 45 0.940007258491471 NA 1.62676154753319 2.4530231507451 -0.826261603211911 0.636426209753723 1.23473451997584 0.680126938835782 1.29828343105424 0.669181585065008 0.25993709371381 NA NA NA 0.134364384027789 97.3130109272077 a3078 gain_cnaBRCA62 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 9 38 2.77258872223978 NA 5.35903198457721 4.92844952199709 0.430582462580126 0.955513197920999 1.03113313638079 0.422927400545508 0.450629529259236 0.417581830501 0.259966126420246 NA NA NA 0.253036465505049 97.3130109272077 a3079 gain_cnaBRCA47_(EGFR) 308 XL-880 MET 7 42 1.63315443905142 NA 1.21159814382035 1.95375104807962 -0.742152904259266 0.917014316594924 1.67059186711398 0.465489877937902 0.809314413994149 0.444245490995577 0.259974975820669 NA NA NA 0.10802736570638 97.3130109272077 a3080 loss_cnaBRCA22_(SYNCRIP,ZNF292) 223 ZSTK474 PI3K 19 30 1.63315443905142 2.32630161961136 0.617911492779213 1.09880805808297 -0.480896565303754 1.57728494172389 1.34546976063196 0.334264638734637 0.304888833071695 0.357419080959411 0.26003564423779 NA NA NA 0.279266235174639 97.3130109272077 a3081 gain_cnaBRCA47_(EGFR) 1026 17-AAG HSP90 6 37 0 NA -0.129158850214537 -1.02059277995742 0.891433929742878 1.91885484409808 1.75250857977872 0.502604168021143 0.464565588420983 0.508661663645284 0.260077341275714 NA NA NA 0.323977393480931 97.3130109272077 a3082 BRCA2_mut 309 Y-39983 ROCK 6 43 2.99573227355399 NA 4.46564106352237 5.00047021056325 -0.534829147040874 0.931985078745241 1.09257416079106 0.49676253795356 0.573860203599966 0.489512901031485 0.260110529517334 NA NA NA 0.238420080389374 97.3130109272077 a3083 gain_cnaBRCA15 52 GNF-2 ABL [T315I] 6 6 0.246860077931526 NA 2.29806277002875 2.67561282314273 -0.37755005311398 0.6458527089926 0.427799365402373 0.689229667968877 0.58457609274858 0.882540002739064 0.260113956439986 NA NA NA 0.264170536414233 97.3130109272077 a3084 BRCA1_mut 186 Bexarotene Retinioic acid X family agonist 4 43 2.07944154167984 NA 4.22215209069164 3.54694065958134 0.675211431110298 0.62336095304236 1.16057999490114 0.596097341966213 1.08317889950418 0.581787928515701 0.260179769373482 NA NA NA 0.115973973401625 97.3130109272077 a3085 loss_cnaBRCA18 301 PHA-793887 CDK-pan 15 33 2.32630161961136 NA 2.52415474423956 3.10323134337707 -0.579076599137506 1.63415781637814 1.63006824945025 0.354975562194367 0.354357818647492 0.355246842782688 0.260213940616762 NA NA NA 0.264735743497389 97.3130109272077 a3086 gain_cnaBRCA16 333 T0901317 LXR 16 32 2.32630161961136 NA 4.91208617624974 4.64711122091968 0.264974955330061 0.939805533840585 0.654896226512097 0.348818831853095 0.281946579147306 0.404606019401406 0.260502034088044 NA NA NA 0.322452949175993 97.3130109272077 a3087 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1143 HG-5-88-01 EGFR, ADCK4 5 21 2.30258509299405 NA 4.98159719915527 4.42752463025157 0.554072568903702 1.18385251200482 0.916498802838966 0.57345011787997 0.468024997442793 0.604553510803718 0.260506228964979 NA NA NA 0.370882450749743 97.3130109272077 a3088 loss_cnaBRCA38 305 TPCA-1 IKK 4 45 2.99573227355399 NA 3.42939860176251 4.24489772244931 -0.815499120686803 1.02833458249679 1.39280028959146 0.594200282440814 0.793028975751041 0.585510447392289 0.260532347199558 NA NA NA 0.214468958845116 97.3130109272077 a3089 gain_cnaBRCA15 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 20 23 -1.38629436111989 0.693147180559945 -2.04424356142248 -2.37378731433835 0.32954375291587 1.03649134008851 0.859572180638543 0.348471607907804 0.317941636528994 0.383381128820461 0.26100271883998 NA NA NA 0.267912565814296 97.3130109272077 a3090 loss_cnaBRCA36_(FAT1,IRF2) 1248 FK866 NAMPT 9 35 0 NA -1.56361687668109 -0.415957325885114 -1.14765955079598 2.24817304737966 2.78989920250057 0.425828517494839 0.510485414872143 0.411362371001554 0.261006716218129 NA NA NA 0.214459697743883 97.3130109272077 a3091 gain_cnaBRCA31 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 16 33 1.63315443905142 NA 3.80859461027715 3.4642022499106 0.344392360366545 1.02548107507282 0.978604484217195 0.3465390461108 0.335834925419845 0.351921911171326 0.261073844105275 NA NA NA 0.272524941646408 97.3130109272077 a3092 loss_cnaBRCA57 1262 UNC1215 LMBL3 5 41 0 NA 3.04103814302989 2.72294496433547 0.318093178694426 0.168212030396109 0.616595302965755 0.539064052143189 1.89102514216952 0.515886477182737 0.261283497772338 NA NA NA 0.0162487601181676 97.3130109272077 a3093 loss_cnaBRCA38 163 JQ1 BRD4 4 43 0.940007258491471 NA -0.472309885709613 0.389240152053502 -0.861550037763116 0.976597267659737 1.4768273074357 0.594639220228723 0.882195830659742 0.583378999985499 0.261331017545002 NA NA NA 0.177925500022018 97.3130109272077 a3094 TP53_mut 1008 Methotrexate Dihydrofolate reductase (DHFR) 35 10 -1.6094379124341 NA 0.780800110448106 0.339124948450008 0.441675161998098 1.05321139625456 1.18559586381968 0.408104268610577 0.419360409096204 0.372534331028397 0.261360343336629 NA NA NA 0.306136445099748 97.3130109272077 a3095 loss_cnaBRCA33 265 Tubastatin A HDAC6 6 43 2.99573227355399 NA 4.244556397942 4.75415992522959 -0.509603527287595 0.786607028622263 1.05380163002848 0.495395161832945 0.64785020822934 0.483585821815274 0.261406998684243 NA NA NA 0.194757070151462 97.3130109272077 a3096 gain_cnaBRCA31 167 OSU-03012 PDPK1 (PDK1) 16 32 2.77258872223978 NA 2.52103240893874 2.11145233690709 0.409580072031647 1.42093198894481 1.03797538957166 0.348096384167661 0.288247484903063 0.39459516684752 0.261477055202151 NA NA NA 0.316177423238759 97.3130109272077 a3097 gain_cnaBRCA47_(EGFR) 300 CX-5461 RNA Pol I 7 42 2.32630161961136 NA 3.23732955966609 4.02487124881666 -0.787541689150569 2.30114978763067 1.59007824101273 0.463936518920571 0.342238342494621 0.495284866390588 0.261547192218843 NA NA NA 0.41244244891154 97.3130109272077 a3098 loss_cnaBRCA20 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 39 -1.38629436111989 0.693147180559945 0.764310977430909 -0.384280103139595 1.1485910805705 1.07598452798484 1.70955020929167 0.682245885830416 1.06747917901909 0.671867415374954 0.261602431725824 NA NA NA 0.194129353235351 97.3130109272077 a3099 PIK3CA_mut 221 TAK-715 p38a 17 32 2.99573227355399 2.32630161961136 4.25952521873011 4.60042357070229 -0.34089835197218 1.0350188099222 0.982186836282478 0.340732943032568 0.329364402563664 0.347080961971005 0.262000882415473 NA NA NA 0.272553964067754 97.3130109272077 a3100 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1005 Cisplatin DNA crosslinker 17 28 1.79175946922805 2.30258509299405 3.92542740411948 3.5150533554052 0.410374048714286 1.15372196737468 1.18701394869469 0.34933286157931 0.35569579181031 0.345719651538684 0.26218533866317 NA NA NA 0.260350267359335 97.3130109272077 a3101 gain_cnaBRCA27_(CLTC,PPM1D) 1259 BMN-673 PARP1 10 36 2.30258509299405 NA 3.79701362558151 3.16901704463968 0.627996580941831 1.33902391583927 1.59586421423307 0.405996721823862 0.468995791272493 0.393515046794647 0.262196758083288 NA NA NA 0.226313314461926 97.3130109272077 a3102 loss_cnaBRCA60 291 KIN001-266 MAP3K8 (COT) 3 46 2.99573227355399 NA 3.03428047767627 3.82717923056735 -0.792898752891078 0.191413969415781 1.19780623370607 0.67612581503571 4.14232438369625 0.661959113735628 0.262268085520766 NA NA NA 0.00114167832403178 97.3130109272077 a3103 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 330 XMD13-2 RIPK 9 39 2.32630161961136 NA 4.1332545840609 3.62589047361789 0.507364110443012 0.818587663910634 1.2760385227356 0.419662921158009 0.61980424676715 0.397608772308309 0.262322516025951 NA NA NA 0.153706820135152 97.3130109272077 a3104 CDH1_mut 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 38 1.38629436111989 0.693147180559945 3.99389143334614 3.37443382742908 0.619457605917059 1.17290952370683 1.02486718142458 0.597526051012253 0.5281375872534 0.604427204953526 0.262419032624756 NA NA NA 0.374542063176064 97.3130109272077 a3105 loss_cnaBRCA60 346 THZ-2-102-1 CDK7 3 45 0.916290731874155 2.99573227355399 -2.93897996702676 -1.22823615012227 -1.7107438169045 0.705506833323367 2.58119571319722 0.67651976469893 2.42484372383163 0.662771834060375 0.262438245491585 NA NA NA 0.0187922829127835 97.3130109272077 a3106 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 303 PIK-93 PI4K, PI3K 9 40 2.99573227355399 NA 3.2742552694018 2.68291338397739 0.591341885424409 0.994997909383756 1.48458598130886 0.418417942490718 0.594314701415455 0.398321075956181 0.262490877881101 NA NA NA 0.163649006620296 97.3130109272077 a3107 PIK3CA_mut 1005 Cisplatin DNA crosslinker 16 29 1.79175946922805 2.30258509299405 3.93777516732612 3.52239162566065 0.415383541665467 1.15526037287354 1.18507239798224 0.353590497098222 0.359558374388156 0.35051321959124 0.262492113101829 NA NA NA 0.2611811419064 97.3130109272077 a3108 loss_cnaBRCA33 163 JQ1 BRD4 6 41 0.940007258491471 NA -0.310668575431628 0.407612157269559 -0.718280732701188 0.876032640387404 1.50534760206559 0.495713196917564 0.819924623337716 0.477152739816097 0.262760584443773 NA NA NA 0.124159057933417 97.3130109272077 a3109 gain_cnaBRCA19 326 GSK690693 AKT 4 44 2.32630161961136 NA 1.89897726100737 3.0341783404641 -1.13520107945673 2.98011818041361 1.82070657355199 0.591926867275195 0.380924852885928 0.623494799187816 0.262896743716478 NA NA NA 0.504878671661106 97.3130109272077 a3110 loss_cnaBRCA23 305 TPCA-1 IKK 3 46 2.99573227355399 NA 5.0481858810152 4.12159639726573 0.926589483749466 0.848222217119668 1.39135203892142 0.675049206176646 1.09239001885132 0.665963363569555 0.263018486076973 NA NA NA 0.187219762065584 97.3130109272077 a3111 gain_cnaBRCA58_(CCND1) 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 5 21 2.30258509299405 NA 5.13763195116956 4.57821077572611 0.559421175443447 0.189800817243784 1.07116607973246 0.570313220808704 2.94741183714144 0.522254378689034 0.263054258429528 NA NA NA 0.034099493407775 97.3130109272077 a3112 BRCA1_mut 254 AC220 FLT3 4 44 0.0237165266173161 NA 2.69987288803598 2.1804790798529 0.51939380818308 0.598992441725252 0.894007866697692 0.591702673624332 0.867112457524659 0.580972301845205 0.263075110645009 NA NA NA 0.183585596452166 97.3130109272077 a3113 loss_cnaBRCA20 333 T0901317 LXR 3 45 2.32630161961136 NA 4.25430374428027 4.76751170347967 -0.513207959199401 0.943742882627194 0.750317183204541 0.675494346115615 0.543800614178654 0.683988012919461 0.263152376757378 NA NA NA 0.446891646317449 97.3130109272077 a3114 gain_cnaBRCA16 312 AV-951 VEGFR 16 32 -2.05572501506252 NA 0.779702189904459 0.558562677673046 0.221139512231413 0.619626357644259 0.646212354110021 0.346795852933051 0.356891713051326 0.342208734984603 0.263238823653037 NA NA NA 0.2592922618963 97.3130109272077 a3115 gain_cnaBRCA62 299 OSI-027 MTORC1/2 10 38 2.99573227355399 NA 0.640525310999486 1.43434963011227 -0.793824319112788 1.41497359159768 2.08588564678909 0.402413676733348 0.561017056308775 0.380569433580772 0.263395346819593 NA NA NA 0.17199899140981 97.3130109272077 a3116 loss_cnaBRCA29_(MAP2K4) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 7 41 0.246860077931526 2.32630161961136 -0.914762649187937 -0.154008567832354 -0.760754081355582 0.541419528539463 1.74959797634778 0.462975467551957 1.40511016181444 0.434816507357666 0.263466489932687 NA NA NA 0.0331234625960347 97.3130109272077 a3117 loss_cnaBRCA20 271 VNLG/124 HDAC, RAR 3 46 1.63315443905142 NA 3.63978649586288 4.18480881931119 -0.545022323448308 1.06052183932262 0.795235377964974 0.674282400783287 0.513919000288035 0.685359754545922 0.263553884370169 NA NA NA 0.468604508710268 97.3130109272077 a3118 gain_cnaBRCA15 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 21 25 0 NA 1.02597242827975 0.340099027820453 0.685873400459302 1.92782778932633 2.14012756411286 0.335167538555441 0.355775243129459 0.320482485231488 0.263640081675251 NA NA NA 0.259322419402537 97.3130109272077 a3119 loss_cnaBRCA36_(FAT1,IRF2) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 9 34 -1.38629436111989 0.693147180559945 -2.53825456479296 -2.13640259926751 -0.40185196552545 0.794491745162406 0.979019844625755 0.424860047812365 0.505797534049023 0.41046355467806 0.263642239028178 NA NA NA 0.219295199173154 97.3130109272077 a3120 gain_cnaBRCA16 32 VX-680 AURKA, AURKB, AURKC, FLT3, ABL1, JAK2 3 9 0.693147180559945 NA -0.0483908964023281 1.60431862106714 -1.65270951746947 3.08956146581195 1.75798848623326 0.789560252838591 0.534933367002988 0.940113960024074 0.263663830774782 NA NA NA 0.456535627671812 97.3130109272077 a3121 gain_cnaBRCA15 1378 Bleomycin (50 uM) DNA damage 23 25 3.91202300542815 NA 4.13185163622549 3.51911431196018 0.612737324265314 1.81792021887715 1.92474051247925 0.326895718362917 0.33705402354993 0.318348016417054 0.263743888132236 NA NA NA 0.262605146016811 97.3130109272077 a3122 TP53_mut 53 CGP-60474 CDK1,CDK2,CDK5,CDK7,CDK9 9 3 -1.36257783450257 NA -1.41205963001568 -2.56468997807485 1.15263034805918 1.57613333406144 0.852239647667075 0.789284112232494 0.73130256378059 1.3524721024355 0.263820466371715 NA NA NA 0.153879433830381 97.3130109272077 a3123 gain_cnaBRCA48 1046 681640 WEE1, CHEK1 3 33 0.693147180559945 NA 1.96978639770697 2.69415929140949 -0.724372893702518 0.6845646912552 1.07650442842536 0.685000400321715 1.0581511184492 0.672893556752089 0.263923622765442 NA NA NA 0.196565070810356 97.3130109272077 a3124 gain_cnaBRCA12_(TERT) 346 THZ-2-102-1 CDK7 9 39 0.916290731874155 2.99573227355399 -2.19428644683883 -1.13689714448802 -1.05738930235081 2.71121509955503 2.48891438912422 0.418109094017808 0.390005685098298 0.424839563374004 0.264069291000206 NA NA NA 0.306663183037218 97.3130109272077 a3125 TP53_mut 110 Roscovitine CDKs 9 4 2.77258872223978 NA 4.29663161467681 3.59265675832485 0.703974856351957 0.880133012794055 1.25230650652437 0.707135495963964 0.799850529543404 0.562142616591329 0.264133881009661 NA NA NA 0.361509197045391 97.3130109272077 a3126 loss_cnaBRCA18 152 CP466722 ATM 16 33 2.77258872223978 NA 2.48557301254131 2.84872054765223 -0.363147535110919 0.901055622554594 1.11987867752343 0.34422078062393 0.403024548119854 0.324273997174415 0.264234558153345 NA NA NA 0.230699467678216 97.3130109272077 a3127 loss_cnaBRCA18 295 NVP-BHG712 EPHB4 16 33 2.32630161961136 NA 3.60355422563793 4.02399505311709 -0.420440827479163 0.86433004477425 1.35709329397739 0.344167204558075 0.48643551155158 0.309809818783297 0.264307924159368 NA NA NA 0.196022788250033 97.3130109272077 a3128 gain_cnaBRCA15 89 Parthenolide NFKB1 6 8 1.6094379124341 NA 2.75392850560977 3.62181849033086 -0.867889984721085 1.6849772194915 1.09578179852884 0.632400756819478 0.515075203795931 0.792028108046952 0.2643352935214 NA NA NA 0.303253172002849 97.3130109272077 a3129 gain_cnaBRCA31 1377 Afatinib (rescreen) ERBB2, EGFR 15 32 2.30258509299405 NA 2.35889760277419 3.05764443964107 -0.698746836866881 2.59565997375005 1.61967783128824 0.353674761334701 0.269198139946417 0.431411002465298 0.264357968708098 NA NA NA 0.349540921013152 97.3130109272077 a3130 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 269 NSC-207895 MDM4 6 43 2.99573227355399 NA 4.0939132995656 4.67510925064792 -0.581195951082326 1.3931310585612 1.15297168965323 0.492186689195278 0.417186845064366 0.504085188125588 0.264467176438666 NA NA NA 0.36664866487051 97.3130109272077 a3131 MLL3_mut 196 Phenformin AAPK1 (AMPK) agonist 3 45 8.29404964010203 NA 6.06542840168097 7.27778539620841 -1.21235699452744 3.49556672383682 1.68341113698394 0.673332034027781 0.346827021283898 0.720178789300121 0.264662811522887 NA NA NA 0.609963357241613 97.3130109272077 a3132 ARID1A_mut 1003 Camptothecin TOP1 5 40 -2.30258509299405 NA -3.28128002702087 -2.43528162115546 -0.845998405865412 1.29469006055429 1.60432596828895 0.536090903227125 0.653437012950588 0.527323263842503 0.264665742918793 NA NA NA 0.232027732867619 97.3130109272077 a3133 gain_cnaBRCA8_(CHD4,WNK1) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 4 44 0.246860077931526 2.32630161961136 -1.15325335352738 -0.184197191166649 -0.969056162360727 0.791047454350853 1.68676401950171 0.589702030987667 1.22502911428487 0.57450606673896 0.264670628833864 NA NA NA 0.0855701071171358 97.3130109272077 a3134 loss_cnaBRCA18 312 AV-951 VEGFR 15 33 -2.05572501506252 NA 0.478141618539735 0.702336861997357 -0.224195243457622 0.726638221944794 0.594653199426808 0.351557036368536 0.308537641823437 0.377018476775583 0.264768912032208 NA NA NA 0.306356325658944 97.3130109272077 a3135 loss_cnaBRCA57 219 AT-7519 CDK9 5 44 2.32630161961136 NA 2.53355967397969 1.57409605216023 0.959463621819462 1.60404584387939 1.81855403710934 0.53265278281355 0.598152244513784 0.527596982130134 0.264775649999124 NA NA NA 0.264401520704184 97.3130109272077 a3136 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1203 QL-XII-61 BTK 3 20 2.30258509299405 NA 3.30666654774079 4.36299271161903 -1.05632616387824 1.98044754782437 1.42768503622989 0.709326847189467 0.533377500978845 0.739887396079812 0.264821827234259 NA NA NA 0.456000352427252 97.3130109272077 a3137 gain_cnaBRCA58_(CCND1) 1133 JNJ-26854165 MDM2 6 37 2.30258509299405 NA 3.33970577143107 2.90867145805032 0.431034313380754 1.19302317881103 0.810649833004394 0.497521154051153 0.361295841552989 0.531714552735148 0.264853799103581 NA NA NA 0.427316796828601 97.3130109272077 a3138 gain_cnaBRCA31 1053 MK-2206 AKT1, AKT2 13 29 1.38629436111989 0.693147180559945 0.96835149948181 1.58463278366277 -0.616281284180961 1.83156560980853 1.54043586260967 0.37733827991532 0.336477864009133 0.400069421349949 0.264991933742781 NA NA NA 0.303090777116294 97.3130109272077 a3139 MACF1_mut 1022 AZD7762 CHEK1, CHEK2 3 42 0.693147180559945 NA -0.110508010607902 0.977269163920297 -1.0877771745282 0.97712989984491 1.63685539645178 0.674729412526076 1.11323701659406 0.664553006261995 0.265141239813705 NA NA NA 0.180585152400283 97.3130109272077 a3140 TP53_mut 1133 JNJ-26854165 MDM2 34 9 2.30258509299405 NA 2.89203595885651 3.25887288614742 -0.366836927290908 0.804418521497296 1.08522219748107 0.42341058550451 0.456027450248286 0.338029325369847 0.265249991352043 NA NA NA 0.364783694120217 97.3130109272077 a3141 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 185 OSI-906 IGF1R 15 33 0.940007258491471 NA 3.16408494022119 2.77049217276735 0.393592767453836 1.04293131299155 1.15360270490512 0.351084426085933 0.377390881404119 0.34118571825489 0.265403074884228 NA NA NA 0.250584721470483 97.3130109272077 a3142 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 204 Tipifarnib Farnesyl-transferase (FNTA) 6 42 2.77258872223978 NA 0.972140348149028 1.71252455312308 -0.740384204974053 1.15602650524152 1.54205329715462 0.491982929446217 0.640456080909122 0.480128803809961 0.265472406335718 NA NA NA 0.199756420928695 97.3130109272077 a3143 gain_cnaBRCA58_(CCND1) 136 Mitomycin C DNA crosslinker 9 39 2.77258872223978 NA 0.363234836170572 -0.249122236921638 0.612357073092211 0.60276761999598 1.59317645481745 0.416659030380374 1.01590903820662 0.384362366918343 0.265706876542958 NA NA NA 0.067587758343988 97.3130109272077 a3144 ARID1A_mut 164 JQ12 HDAC 5 42 1.63315443905142 NA 0.800758385036056 1.6703980268161 -0.869639641780047 1.20966697314567 1.66674552153782 0.533092619094608 0.718908312027896 0.521759099120107 0.265782058255029 NA NA NA 0.196896839129023 97.3130109272077 a3145 PIK3CA_mut 1047 Nutlin-3a MDM2 15 28 2.07944154167984 1.38629436111989 3.97228236391093 4.33265646313767 -0.360374099226734 1.1910003493735 0.881998729922891 0.360979321084385 0.302581018902557 0.408588002454652 0.265808709104759 NA NA NA 0.313861406508282 97.3130109272077 a3146 loss_cnaBRCA22_(SYNCRIP,ZNF292) 157 JNK-9L JNK 17 30 1.63315443905142 NA 0.284914949577646 -0.0739624048332435 0.35887735441089 1.1022654041187 1.01880754444159 0.342034786717943 0.325581618610106 0.352252352634069 0.265843882674465 NA NA NA 0.278920819663296 97.3130109272077 a3147 loss_cnaBRCA38 1059 AZD8055 MTORC1/2 3 40 0.693147180559945 NA -0.498265887519803 0.177582980236959 -0.675848867756762 1.72105717967869 0.949328047860547 0.675257850966938 0.392694023032366 0.711923417073674 0.265859341343033 NA NA NA 0.567852864093851 97.3130109272077 a3148 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1049 PD-173074 FGFR1, FGFR3 15 28 0.693147180559945 NA 3.20449772360114 2.79487091827319 0.40962680532795 0.855360322425599 1.25571090375001 0.360905974200325 0.478893858632986 0.326211076215596 0.26590438643037 NA NA NA 0.213989331645333 97.3130109272077 a3149 gain_cnaBRCA27_(CLTC,PPM1D) 153 Midostaurin KIT 9 38 -0.669430653942629 NA 1.10035467219424 0.496564710107943 0.603789962086294 1.550933291136 1.42303944366371 0.417384772130914 0.389307499901585 0.42429601285808 0.266175795063597 NA NA NA 0.308273255848832 97.3130109272077 a3150 gain_cnaBRCA8_(CHD4,WNK1) 133 Doxorubicin DNA intercalating 3 45 0.0237165266173161 NA -2.17808134593685 -0.954149226040416 -1.22393211989644 2.25640641205321 1.80200659478483 0.670971870061369 0.542425386383618 0.679205128015962 0.266318484551756 NA NA NA 0.44789189645327 97.3130109272077 a3151 loss_cnaBRCA18 310 YM201636 FYV1 16 33 1.63315443905142 NA 2.18136279400875 2.5277849091525 -0.346422115143757 0.987494304382679 1.02189074690445 0.342639273236783 0.350809228576076 0.339001127266443 0.266406347256301 NA NA NA 0.263720517051732 97.3130109272077 a3152 loss_cnaBRCA57 273 CUDC-101 HDAC, EGFR 5 44 1.63315443905142 NA 0.716607592453848 -0.111109432175224 0.827717024629072 1.55371614514647 1.55998526238317 0.530774048965126 0.532733747547589 0.530592848912289 0.26644229191729 NA NA NA 0.310745044059004 97.3130109272077 a3153 loss_cnaBRCA33 1004 Vinblastine Microtubules 5 40 -2.30258509299405 NA -2.8502980867364 -3.53121813926451 0.680920052528114 0.970908990317104 1.30224737163075 0.534028729998986 0.701322224141443 0.522880727089066 0.266481379173996 NA NA NA 0.206501521080733 97.3130109272077 a3154 gain_cnaBRCA19 260 NG-25 MAP3K7 (TAK1) 4 45 2.32630161961136 NA 2.51995747506405 3.26953326508522 -0.749575790021169 1.2657311555199 1.27850395392524 0.586663692127661 0.592207742341048 0.586291335055972 0.266546127799033 NA NA NA 0.327173496076675 97.3130109272077 a3155 ASH1L_mut 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 3 40 -1.38629436111989 0.693147180559945 -2.81362193634168 -2.17602784123017 -0.637594095111506 0.774911567360741 0.953983241540429 0.673964761731616 0.822795944681891 0.668349366475203 0.266762056235006 NA NA NA 0.286920438782251 97.3130109272077 a3156 TP53_mut 295 NVP-BHG712 EPHB4 38 11 2.32630161961136 NA 3.99224165083016 3.52213833013865 0.470103320691511 1.0555096338268 1.70112600111383 0.384766630984941 0.445380416839144 0.276348324805867 0.266806860628645 NA NA NA 0.401271190505983 97.3130109272077 a3157 gain_cnaBRCA47_(EGFR) 1373 Dabrafenib BRAF 6 40 2.30258509299405 NA 4.91022386312541 4.11024392179644 0.799979941328966 0.475590854493213 1.71747918653147 0.492331179457961 1.68207595619437 0.465787269855983 0.266871583798718 NA NA NA 0.0231537430253468 97.3130109272077 a3158 gain_cnaBRCA10_(MDM2,NUP107) 235 QL-XII-47 BTK, BMX 5 44 2.32630161961136 NA 2.42002156179612 1.62717208720977 0.79284947458635 0.447822407531499 1.55742629037671 0.530193295931662 1.77045512071787 0.509076724520026 0.26695898770558 NA NA NA 0.0186896494388072 97.3130109272077 a3159 gain_cnaBRCA15 166 FTI-277 Farnesyl transferase (FNTA) 22 25 0.0237165266173161 NA 2.38595072945829 2.1198126403987 0.266138089059587 0.980237825523821 0.624240915268496 0.328532543160881 0.271503590383657 0.42633874606748 0.267033683338311 NA NA NA 0.281801000737237 97.3130109272077 a3160 loss_cnaBRCA17 34 Imatinib ABL, KIT, PDGFR 4 10 0.693147180559945 NA 3.00473827314999 2.68646634840813 0.318271924741863 0.346157531811812 0.494880517401156 0.688590144432152 0.919442437308835 0.643128823121295 0.26707268182385 NA NA NA 0.209242918211363 97.3130109272077 a3161 loss_cnaBRCA33 309 Y-39983 ROCK 6 43 2.99573227355399 NA 4.47254282325343 4.9995071743217 -0.526964351068274 0.990451251286389 1.08691514604605 0.489260122821601 0.532044712330725 0.48482565818063 0.267280630438964 NA NA NA 0.268156665946207 97.3130109272077 a3162 gain_cnaBRCA63 1378 Bleomycin (50 uM) DNA damage 6 42 3.91202300542815 NA 4.61668269164339 3.69786545910311 0.918817232540284 2.12857969213674 1.84145008109245 0.49009043690101 0.431657426750109 0.498963964309686 0.267290575236654 NA NA NA 0.352987026925833 97.3130109272077 a3163 MLL3_mut 263 FR-180204 ERK 3 46 2.99573227355399 NA 4.90028172188425 5.38772857420573 -0.487446852321487 0.432148000436297 0.739311455529102 0.668759269551018 1.12796276236234 0.65932544217462 0.267433172375202 NA NA NA 0.176770068913102 97.3130109272077 a3164 BRCA1_mut 200 LAQ824 HDAC 4 44 0.0237165266173161 NA -1.93086000616281 -2.75297717385973 0.822117167696918 0.785863027052741 1.43555861484768 0.586224888125868 1.0461329002589 0.572681017127363 0.267460026373674 NA NA NA 0.12559799409072 97.3130109272077 a3165 gain_cnaBRCA58_(CCND1) 157 JNK-9L JNK 9 38 1.63315443905142 NA 0.408981006499318 -0.0277933437018731 0.436774350201191 0.7625420112892 1.10157784164639 0.41623661264135 0.57278726120644 0.396498852544455 0.267475221215635 NA NA NA 0.177854185143391 97.3130109272077 a3166 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 39 2.30258509299405 NA 3.72927332083721 3.09188138704647 0.637391933790739 0.902584518453139 1.33701848684048 0.492567909822828 0.706185316454475 0.476726343026838 0.267573035904796 NA NA NA 0.169661546118283 97.3130109272077 a3167 ASH1L_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 43 1.38629436111989 NA 1.93589304072819 2.92298479303233 -0.987091752304136 1.08213127822994 1.48813631847224 0.670527269156225 0.912173755774568 0.663307346276925 0.26757933970375 NA NA NA 0.249005569923369 97.3130109272077 a3168 ASH1L_mut 1175 AG-014699 PARP1, PARP2 3 40 1.6094379124341 NA 3.223460702029 3.90942889454227 -0.685968192513271 1.95094518616543 0.947475127030575 0.67278104655438 0.351608131985265 0.72399598991387 0.26759033118287 NA NA NA 0.605542776748979 97.3130109272077 a3169 loss_cnaBRCA24 225 Genentech Cpd 10 AURKA, AURKB 3 46 2.32630161961136 NA 2.01127068122554 3.08372384464812 -1.07245316342258 1.22908854478869 1.61905295894799 0.668448845708987 0.872559725635526 0.662395357418962 0.267652401691326 NA NA NA 0.265270431558605 97.3130109272077 a3170 loss_cnaBRCA28_(GPS2) 173 FH535 unknown 4 44 3.46573590279973 NA 0.889514378919144 1.63513295122255 -0.745618572303408 1.04668386196844 1.28684606235605 0.585917577584399 0.712362728991698 0.579415513723743 0.267707554202022 NA NA NA 0.254622390331302 97.3130109272077 a3171 MACF1_mut 1043 JNK Inhibitor VIII JNK 3 40 2.30258509299405 NA 5.26094188479955 4.76256037840473 0.498381506394826 0.31909857296785 0.75632130657185 0.67257691757239 1.56184185268995 0.658954735327795 0.267733350418043 NA NA NA 0.0857495058311364 97.3130109272077 a3172 loss_cnaBRCA18 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 12 31 0.693147180559945 NA 3.16988068180993 2.80720760127324 0.362673080536688 0.7419562448715 1.01492165195077 0.38199364824417 0.488806561092427 0.357340963058181 0.267738744159715 NA NA NA 0.207994232860881 97.3130109272077 a3173 loss_cnaBRCA42 308 XL-880 MET 3 46 1.63315443905142 NA 0.847043780022496 1.91299129752215 -1.06594751749965 1.31620833457632 1.60631641129334 0.668286113349199 0.809862306367157 0.663597476814293 0.267767378401678 NA NA NA 0.292947124941573 97.3130109272077 a3174 loss_cnaBRCA34 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 5 41 2.30258509299405 NA 1.88181013600533 1.35602427861207 0.525785857393261 0.753317791638365 1.00953652463736 0.531638853718519 0.697960227714451 0.520819053656459 0.267815791650079 NA NA NA 0.207893756942938 97.3130109272077 a3175 BRCA2_mut 163 JQ1 BRD4 6 41 0.940007258491471 NA -0.304155551775725 0.4066590318565 -0.710814583632225 1.85684269087779 1.39011280615266 0.490415600931176 0.382808186780864 0.511335900573067 0.267824586114882 NA NA NA 0.402943192692968 97.3130109272077 a3176 gain_cnaBRCA19 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 3 40 -1.38629436111989 0.693147180559945 -1.6287790342176 -2.26489105888948 0.636112024671874 0.825294211207575 0.951884767949752 0.672349886953577 0.770770006663577 0.668265788139445 0.267892479241799 NA NA NA 0.311655140127434 97.3130109272077 a3177 gain_cnaBRCA10_(MDM2,NUP107) 329 QL-XI-92 DDR1 5 43 2.32630161961136 NA 4.70001269668818 4.20139584255364 0.498616854134537 0.174861278732248 0.983381190483787 0.529842040621113 2.85149953008197 0.507043310325304 0.267954561360962 NA NA NA 0.00542468242535618 97.3130109272077 a3178 gain_cnaBRCA13_(FGFR1,WHSC1L1) 306 TG101348 JAK2 11 37 2.32630161961136 NA 3.60352072808773 3.11232272190748 0.491198006180247 1.45412214780373 1.22133970642106 0.385083163313988 0.337796936056671 0.402179674989544 0.267969683224399 NA NA NA 0.325131888067802 97.3130109272077 a3179 gain_cnaBRCA9_(KRAS) 230 GSK429286A ROCK2 4 45 2.99573227355399 2.32630161961136 5.88451677256258 5.36292463610018 0.521592136462397 0.260688806494775 0.919232362481145 0.584845069433548 2.00082291018065 0.567421424387781 0.268011939463168 NA NA NA 0.0170356446626601 97.3130109272077 a3180 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 272 AR-42 HDAC 6 43 1.63315443905142 NA -0.510113008057352 0.23295675449897 -0.743069762556322 0.712483968219382 1.59032331500084 0.488473285480776 1.04292839656923 0.467244462523602 0.268040666773035 NA NA NA 0.0705672476236919 97.3130109272077 a3181 gain_cnaBRCA13_(FGFR1,WHSC1L1) 282 EKB-569 EGFR 11 36 0.916290731874155 2.99573227355399 2.20039316609862 1.38791237277136 0.812480793327263 1.80182729476553 2.18151838049743 0.386329917466373 0.450920460405718 0.37243820661369 0.268070100011086 NA NA NA 0.228412165568627 97.3130109272077 a3182 loss_cnaBRCA28_(GPS2) 185 OSI-906 IGF1R 4 44 0.940007258491471 NA 3.49513395933293 2.83879499925701 0.656338960075917 0.446017623771813 1.15370680012165 0.585362524547224 1.47155386938635 0.568895806115307 0.268155041921214 NA NA NA 0.0506586603282005 97.3130109272077 a3183 loss_cnaBRCA18 176 IPA-3 PAK1, PAK2, PAK3 15 32 3.46573590279973 NA 4.85516975874075 4.32887211778315 0.526297640957596 1.19819054972888 1.61840623519277 0.35078602564145 0.439243692146198 0.325195015635186 0.268225569318396 NA NA NA 0.219683230853338 97.3130109272077 a3184 CDH1_mut 1259 BMN-673 PARP1 5 41 2.30258509299405 NA 4.0380599511744 3.21620610017004 0.821853851004365 1.34429445286986 1.56622209380087 0.531132008869565 0.611364459066119 0.524736468893699 0.268265883524791 NA NA NA 0.257125125552769 97.3130109272077 a3185 loss_cnaBRCA38 1023 GW 441756 NTRK1 3 42 0.693147180559945 NA 3.16831263085971 2.30149923089721 0.866813399962495 0.508720643436647 1.31985797987863 0.670151123662631 1.70390844394826 0.656747478272021 0.268350742563017 NA NA NA 0.0674219607671596 97.3130109272077 a3186 gain_cnaBRCA63 1001 AICAR AAPK1 (AMPK) agonist 6 39 7.60090245954208 NA 8.32318205985899 7.64852963967522 0.674652420183767 1.8529517250522 1.29554986310181 0.491711803145902 0.364096058770642 0.520746008624099 0.268393612186418 NA NA NA 0.423992941823087 97.3130109272077 a3187 loss_cnaBRCA36_(FAT1,IRF2) 1192 GSK269962A ROCK1, ROCK2 9 37 1.6094379124341 NA 2.18054866185895 2.78649917287561 -0.60595051101666 1.90358418618021 1.33453091109676 0.416561506372166 0.318320836775061 0.45405505858135 0.268459490301825 NA NA NA 0.388004547867557 97.3130109272077 a3188 NF1_mut 1377 Afatinib (rescreen) ERBB2, EGFR 5 42 2.30258509299405 NA 1.89858531674798 2.94607522681874 -1.04748991007076 2.27628414695202 1.94438710791376 0.530066638538882 0.460175374622435 0.538724982184576 0.268467751383022 NA NA NA 0.371479385306251 97.3130109272077 a3189 ARID1A_mut 167 OSU-03012 PDPK1 (PDK1) 5 43 2.77258872223978 NA 1.69000200130419 2.31286007715176 -0.622858075847568 1.7845057025935 1.10193278931107 0.529143671906408 0.349036752834324 0.565241439305007 0.268577404925607 NA NA NA 0.484263858949594 97.3130109272077 a3190 gain_cnaBRCA16 1259 BMN-673 PARP1 16 30 2.30258509299405 NA 3.65557320066789 3.11885262173857 0.536720578929316 0.99169941278748 1.76754995923926 0.346854622295945 0.541212964340369 0.303652282145573 0.268604199180557 NA NA NA 0.194057619639958 97.3130109272077 a3191 loss_cnaBRCA38 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 3 43 2.30258509299405 NA 2.03154460103177 1.37003284418666 0.661511756845117 0.438861990385114 1.00778095782058 0.668838090920661 1.50733435872316 0.656404302652925 0.268769685097689 NA NA NA 0.0944851956470376 97.3130109272077 a3192 gain_cnaBRCA16 166 FTI-277 Farnesyl transferase (FNTA) 16 31 0.0237165266173161 NA 2.42854754281377 2.14933778622676 0.279209756587018 1.10600586441363 0.610678469810429 0.34463290457588 0.252448712588922 0.457212379984007 0.268840177279198 NA NA NA 0.359197943024814 97.3130109272077 a3193 TP53_mut 184 BMS-754807 IGF1R 38 10 0.940007258491471 NA 1.76514960867098 1.10140246951368 0.663747139157297 1.62526180590003 1.83682483132776 0.397747187004223 0.408393981048321 0.361355708958651 0.268897079967545 NA NA NA 0.317120079874559 97.3130109272077 a3194 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 276 CAY10603 HDAC6 15 34 2.99573227355399 NA 0.938266219597025 1.28021924206754 -0.341953022470519 0.900765040128642 1.02016356983154 0.346769304687238 0.379625104479725 0.335194308621494 0.268938023189368 NA NA NA 0.249187983053102 97.3130109272077 a3195 gain_cnaBRCA63 1149 TW 37 BCL2, BCL2L1 6 37 1.6094379124341 NA 0.383240910000853 -0.227620753493125 0.610861663493978 1.04566113141994 1.26331865404401 0.493097944135482 0.584187023060201 0.483537278214445 0.26906097781132 NA NA NA 0.236043443544758 97.3130109272077 a3196 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1259 BMN-673 PARP1 6 40 2.30258509299405 NA 3.96455465153729 3.20668554884049 0.7578691026968 0.807092566091831 1.61806329261496 0.489749929653804 0.939011378046282 0.468380381753797 0.269352228710389 NA NA NA 0.0937404109272614 97.3130109272077 a3197 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 196 Phenformin AAPK1 (AMPK) agonist 15 33 8.29404964010203 NA 6.770924637313 7.39796237802201 -0.627037740709013 2.0982832700035 1.65424169426827 0.348158602385837 0.298833694035966 0.37904844430026 0.269353086500218 NA NA NA 0.317772814193966 97.3130109272077 a3198 gain_cnaBRCA16 53 CGP-60474 CDK1,CDK2,CDK5,CDK7,CDK9 3 9 -1.36257783450257 NA -2.55494502361332 -1.41530794816952 -1.1396370754438 0.788520108886651 1.58704447514705 0.779163500381035 1.44528600171391 0.718087673843046 0.269612462101703 NA NA NA 0.143183018792294 97.3130109272077 a3199 gain_cnaBRCA31 150 Bicalutamide ANDR (androgen receptor) 16 32 0.0237165266173161 NA 2.90394225479344 2.69191048778234 0.212031767011105 0.671317209634182 0.593315883434174 0.342080195229234 0.315844378735124 0.357367420848138 0.269697804730389 NA NA NA 0.293484050245453 97.3130109272077 a3200 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 204 Tipifarnib Farnesyl-transferase (FNTA) 9 39 2.77258872223978 NA 2.1252379872919 1.50337772908811 0.621860258203786 1.55417559951727 1.49475770896961 0.413124884278874 0.400122263145128 0.416027463496045 0.269728271785966 NA NA NA 0.297845511475914 97.3130109272077 a3201 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 328 SNX-2112 HSP90 15 33 0.940007258491471 NA -0.0677360195613122 0.637683582359713 -0.705419601921025 1.81590528709529 2.11414909148421 0.347835307622821 0.388467177739986 0.333665967439314 0.269792094679491 NA NA NA 0.245510531884139 97.3130109272077 a3202 loss_cnaBRCA22_(SYNCRIP,ZNF292) 45 Z-LLNle-CHO g-secretase 3 9 0.940007258491471 NA 0.109405389034261 1.26333907193383 -1.15393368289957 1.00515233435853 1.57843830089288 0.778824894692334 1.14801870667295 0.731060366595785 0.269807975269026 NA NA NA 0.193862264531029 97.3130109272077 a3203 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1008 Methotrexate Dihydrofolate reductase (DHFR) 5 40 -1.6094379124341 NA 1.192790248262 0.618882552721845 0.573907695540154 0.543672168925297 1.12359841919973 0.530005171314995 1.05561352657544 0.510776524542383 0.270049414997696 NA NA NA 0.0885355369921691 97.3130109272077 a3204 BRCA1_mut 177 GSK-650394 SGK3 4 43 2.77258872223978 NA 4.91477622040942 3.93068649410092 0.984089726308495 0.907781016748815 1.72810445602556 0.58372448054009 1.0840607020325 0.569461945935716 0.270064324335706 NA NA NA 0.116138101906898 97.3130109272077 a3205 loss_cnaBRCA33 256 JW-7-24-1 LCK 6 42 2.32630161961136 NA 1.34429122770503 1.90803740020177 -0.563746172496735 0.542834058279379 1.21085397281866 0.487215167588511 1.03852395386472 0.465577340580906 0.270069818453965 NA NA NA 0.072479755578133 97.3130109272077 a3206 loss_cnaBRCA33 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 5 41 0 NA -0.312112912599029 0.770938079326374 -1.0830509919254 3.62510654559529 1.815418453612 0.529054305074545 0.298763906192322 0.59658476522068 0.270116557088777 NA NA NA 0.544456232573033 97.3130109272077 a3207 loss_cnaBRCA38 133 Doxorubicin DNA intercalating 4 44 0.0237165266173161 NA -2.00541629660047 -0.942029409618804 -1.06338688698167 1.05696398337813 1.86632432880664 0.582831972301181 1.00607674784055 0.569776040835096 0.270201916474489 NA NA NA 0.136894274822921 97.3130109272077 a3208 loss_cnaBRCA38 1494 SN-38 TOP1 4 44 -2.99573227355399 NA -4.19790870356828 -3.22250485595589 -0.975403847612389 1.83410166701908 1.6620215663802 0.582753877844524 0.53181558315559 0.586877972791154 0.270265259888077 NA NA NA 0.371125335237914 97.3130109272077 a3209 gain_cnaBRCA62 155 AP-24534 ABL 9 38 -0.669430653942629 NA 1.82268070925612 1.35599427314874 0.466686436107379 1.152466347172 1.12268650477049 0.41371511435413 0.404945825318514 0.415687223569844 0.270344721621575 NA NA NA 0.294093293080565 97.3130109272077 a3210 PTEN_mut 298 OSI-930 KIT, VEGFR, PDGFR 9 39 2.32630161961136 NA 3.6221548159169 3.98057017656346 -0.358415360646562 0.760454954404163 0.889961722779265 0.412528067324858 0.471317016965706 0.402731209076347 0.270411605948224 NA NA NA 0.23867949631685 97.3130109272077 a3211 gain_cnaBRCA47_(EGFR) 165 DMOG Prolyl-4-Hydroxylase 6 40 8.29404964010203 NA 6.92174011295915 7.6672166476189 -0.745476534659749 1.69685327647776 1.50246651230121 0.488579607615405 0.439328812333833 0.496168485990386 0.270482314020808 NA NA NA 0.346573387506995 97.3130109272077 a3212 loss_cnaBRCA18 133 Doxorubicin DNA intercalating 16 32 0.0237165266173161 NA -1.4460025380876 -0.822966206257114 -0.623036331830488 1.39458697458914 1.99967978264963 0.341473764376349 0.446753299136499 0.311568050663065 0.270536508103506 NA NA NA 0.216670181366813 97.3130109272077 a3213 gain_cnaBRCA62 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 7 36 1.6094379124341 NA 3.41561824050607 2.76146964956213 0.654148590943931 1.90115875072076 1.31746429312167 0.461327084405379 0.344078889096416 0.496520926114786 0.270582500230951 NA NA NA 0.412196273099105 97.3130109272077 a3214 loss_cnaBRCA23 1091 BMS-536924 IGF1R 3 44 1.38629436111989 NA 3.70113782856867 2.97708615491896 0.72405167364971 0.692745123447994 1.10296926339206 0.665472536129345 1.04519201816376 0.656456800457855 0.270668309298435 NA NA NA 0.201490780521721 97.3130109272077 a3215 gain_cnaBRCA10_(MDM2,NUP107) 1013 Nilotinib ABL 3 37 0.693147180559945 NA 3.79312747916383 3.15505169888462 0.638075780279203 0.338340082320384 0.973763825414287 0.670976996242434 1.88590064736992 0.655267492615814 0.270696851034421 NA NA NA 0.0488173920903622 97.3130109272077 a3216 gain_cnaBRCA12_(TERT) 1006 Cytarabine DNA synthesis 10 35 0.693147180559945 NA 0.736110438742829 1.34351122795145 -0.607400789208616 0.894966358740115 1.64504112637842 0.399865608649959 0.678685610109057 0.369231370248973 0.270970637584032 NA NA NA 0.137057104156846 97.3130109272077 a3217 BRCA1_mut 223 ZSTK474 PI3K 4 45 1.63315443905142 2.32630161961136 1.68067779635203 0.844041087108576 0.83663670924345 1.747982730428 1.41607529291526 0.581179692184427 0.478629848384485 0.590813718330664 0.270983587305001 NA NA NA 0.414013144705258 97.3130109272077 a3218 loss_cnaBRCA22_(SYNCRIP,ZNF292) 273 CUDC-101 HDAC, EGFR 19 30 1.63315443905142 NA 0.285245163609613 -0.224181172067442 0.509426335677054 1.95341843402451 1.25493443029013 0.32658827147472 0.260787103676254 0.405938607931318 0.270993031710941 NA NA NA 0.320304242233393 97.3130109272077 a3219 BRCA1_mut 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 4 44 2.77258872223978 NA 0.309721465289069 -0.504367989431859 0.814089454720928 0.630685176982776 1.43819421331577 0.581574384813103 1.29080163040388 0.566049735969968 0.271223240864157 NA NA NA 0.0745844160059467 97.3130109272077 a3220 MLL3_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 43 1.38629436111989 NA 3.77441608947701 2.79471574311962 0.979700346357389 0.78614760254373 1.49728178639239 0.665364096650155 1.24620407565625 0.654319283959177 0.271229579892141 NA NA NA 0.145572286045346 97.3130109272077 a3221 loss_cnaBRCA42 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 3 44 2.32630161961136 NA 0.468860120767607 1.48157783212139 -1.01271771135378 0.393807358573605 1.55643474996347 0.664636055685126 2.57160687657516 0.650665060888386 0.271262909046172 NA NA NA 0.0144509291337242 97.3130109272077 a3222 MLL3_mut 1527 GDC0941 (rescreen) PI3K 3 42 1.38629436111989 NA 0.266702273866663 1.03165252475625 -0.764950250889591 0.752982541984972 1.16492120603117 0.665729473084709 1.01589374020953 0.656654069759568 0.271476569451911 NA NA NA 0.210967875900187 97.3130109272077 a3223 TP53_mut 221 TAK-715 p38a 38 11 2.99573227355399 2.32630161961136 4.56775766269221 4.18642652714374 0.381331135548475 1.00382523394493 0.990543081254599 0.380944856070637 0.379878013277156 0.384971782414037 0.271524357376248 NA NA NA 0.278397884175504 97.3130109272077 a3224 loss_cnaBRCA57 177 GSK-650394 SGK3 5 42 2.77258872223978 NA 4.80784048125503 3.9199862314691 0.887854249785934 0.79341378484432 1.74888531608981 0.526596131617569 1.11903053204469 0.50766865135046 0.271571633249171 NA NA NA 0.0754479766199215 97.3130109272077 a3225 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 194 AUY922 HSP90 5 42 -1.36257783450257 NA -3.20187979349605 -2.29754079877919 -0.90433899471686 1.02243989692997 1.77074407550071 0.526549423686692 0.884491105474535 0.510711292065817 0.271613579494308 NA NA NA 0.131733756012109 97.3130109272077 a3226 MLL3_mut 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 3 42 -0.669430653942629 NA -4.98691650359681 -3.37899684641187 -1.60791965718494 1.1547777373835 2.46122933639078 0.665480267352663 1.39240617924292 0.653299403436673 0.271653507548684 NA NA NA 0.114265175886186 97.3130109272077 a3227 loss_cnaBRCA20 277 ABT-869 VEGFR and PDGFR family 3 45 0.0237165266173161 NA 2.39706498094141 2.71067913239026 -0.313614151448849 0.456677991564683 0.473441792670858 0.663417328795016 0.686729286809587 0.66241332367309 0.271667499806963 NA NA NA 0.356108445500369 97.3130109272077 a3228 loss_cnaBRCA24 235 QL-XII-47 BTK, BMX 3 46 2.32630161961136 NA 0.777883177385276 1.76873978508815 -0.990856607702869 1.75234479094635 1.48337320199661 0.662423917775294 0.565446145542945 0.667975265003562 0.271932627930712 NA NA NA 0.431800530082849 97.3130109272077 a3229 gain_cnaBRCA58_(CCND1) 308 XL-880 MET 10 39 1.63315443905142 NA 2.34808727692755 1.71943226299515 0.628655013932398 1.90068150859317 1.51412093571448 0.39403974997295 0.330752422796868 0.415194717346503 0.271936125543346 NA NA NA 0.35105698638787 97.3130109272077 a3230 gain_cnaBRCA58_(CCND1) 1061 SB590885 BRAF 8 34 1.6094379124341 NA 4.39466630170327 3.92185178928811 0.472814512415165 0.555012493074824 1.16212179917619 0.437474093982672 0.85189886410615 0.406854524844416 0.272225323993506 NA NA NA 0.104116509601556 97.3130109272077 a3231 gain_cnaBRCA10_(MDM2,NUP107) 266 Zibotentan, ZD4054 Endothelin A Receptor 5 44 2.99573227355399 NA 5.97255993457138 5.71584386744976 0.256716067121618 0.293846801865828 0.504091858001385 0.5242041521141 0.873639139482061 0.509264458544205 0.272329039274894 NA NA NA 0.134357907678729 97.3130109272077 a3232 loss_cnaBRCA18 1192 GSK269962A ROCK1, ROCK2 15 31 1.6094379124341 NA 3.01070585835091 2.50209095089886 0.508614907452049 1.25564205957269 1.53920097099044 0.349567250650099 0.405063611540008 0.330440869670687 0.272423841265062 NA NA NA 0.240964141909674 97.3130109272077 a3233 gain_cnaBRCA12_(TERT) 151 QS11 ARFGAP 9 39 2.32630161961136 NA 4.25160365778359 3.64710671621067 0.604496941572926 1.42829586368423 1.48156347742589 0.410541531124763 0.423229498133286 0.408012853167247 0.272694946674301 NA NA NA 0.277428481580193 97.3130109272077 a3234 gain_cnaBRCA62 177 GSK-650394 SGK3 9 38 2.77258872223978 NA 4.57559688350199 3.88153295201209 0.694063931489901 1.52430823936583 1.71912375300575 0.411629916426804 0.455330433547128 0.403731220789885 0.272734133444066 NA NA NA 0.252049875295545 97.3130109272077 a3235 loss_cnaBRCA34 1143 HG-5-88-01 EGFR, ADCK4 3 23 2.30258509299405 NA 3.94433687227016 4.61099967888039 -0.66666280661023 1.00933351476385 0.96361628502051 0.689051062760801 0.660498038417168 0.69183430891897 0.272751352663245 NA NA NA 0.372612035830629 97.3130109272077 a3236 MACF1_mut 1017 Olaparib PARP1, PARP2 3 42 1.6094379124341 NA 4.62182395121648 4.03497482257503 0.586849128641456 0.49020935177462 0.89886354594301 0.663815143989436 1.19713980673153 0.652878995138004 0.272837856730944 NA NA NA 0.157498073237375 97.3130109272077 a3237 loss_cnaBRCA18 254 AC220 FLT3 15 33 0.0237165266173161 NA 2.01514823584344 2.31858628872788 -0.303438052884438 1.14186075579239 0.733781332750755 0.345488909137418 0.265739978666548 0.413526536232433 0.272993507792699 NA NA NA 0.356559613905832 97.3130109272077 a3238 gain_cnaBRCA48 1016 Temsirolimus MTOR 4 40 -1.6094379124341 NA -0.962406697259403 -1.82979438530088 0.867387688041473 1.35162224394339 1.49927138400237 0.5824479811204 0.641738245969413 0.578539480774949 0.273022397099293 NA NA NA 0.296095342945824 97.3130109272077 a3239 loss_cnaBRCA18 235 QL-XII-47 BTK, BMX 16 33 2.32630161961136 NA 1.36772668440951 1.87309250592904 -0.50536582151953 1.20645579603249 1.61380050669478 0.337834586625946 0.418884656347509 0.313152598120426 0.273081991660437 NA NA NA 0.227580069208679 97.3130109272077 a3240 ASH1L_mut 1114 Cetuximab EGFR 3 42 4.18661983833127 NA 5.74240512700206 6.32116933571386 -0.578764208711802 0.907875846595041 0.870674751042895 0.663385527756049 0.637492682377705 0.664730667816607 0.273144021595344 NA NA NA 0.38517579727476 97.3130109272077 a3241 ASH1L_mut 223 ZSTK474 PI3K 3 46 1.63315443905142 2.32630161961136 1.80516583513486 0.854110056519336 0.951055778615525 0.44894326772311 1.46832463130162 0.660581230461463 2.11843198682756 0.647714925120098 0.273251317110203 NA NA NA 0.0326175263693278 97.3130109272077 a3242 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1243 piperlongumine Increases ROS levels 15 32 2.30258509299405 NA 1.91078732896782 1.61624397441784 0.294543354549974 1.05756369739502 0.735094448617448 0.347072045549503 0.278511219017342 0.400687768903637 0.273256852195144 NA NA NA 0.341364819705391 97.3130109272077 a3243 PIK3CA_mut 1149 TW 37 BCL2, BCL2L1 15 28 1.6094379124341 NA 0.144247022686313 -0.295936705697686 0.440183728383999 1.54296007693357 1.04749947137428 0.355227988830533 0.285285235155796 0.420223341789847 0.273385762957301 NA NA NA 0.333639233979178 97.3130109272077 a3244 gain_cnaBRCA16 1013 Nilotinib ABL 13 27 0.693147180559945 NA 3.44377200993078 3.08693552470823 0.356836485222548 1.04779919447089 0.903041878024133 0.375168020385169 0.340558083176176 0.39514943205437 0.273401676934674 NA NA NA 0.303999608172943 97.3130109272077 a3245 gain_cnaBRCA63 1129 PF-4708671 RPS6KB1 (p70S6KA) 6 37 2.30258509299405 NA 4.28723783848979 3.73140947764755 0.555828360842237 1.50521063189112 1.07676350471297 0.488560909947965 0.3692694889777 0.516202823005601 0.273425618710003 NA NA NA 0.418929254582156 97.3130109272077 a3246 gain_cnaBRCA64_(SDHC) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 9 38 -2.30258509299405 NA 0.201988888240133 -0.22174666559895 0.423735553839083 1.24761969831532 0.978170864844286 0.410902514355815 0.339635190444057 0.433191755211945 0.273571160833674 NA NA NA 0.362613306450254 97.3130109272077 a3247 PIK3CA_mut 1230 IOX2 EGLN1 16 31 -2.30258509299405 NA 0.395740964451426 0.173964259590756 0.22177670486067 0.637065355482092 0.656483711564883 0.341155367673989 0.348122375439554 0.337825144712292 0.273635253573301 NA NA NA 0.271595343433722 97.3130109272077 a3248 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1016 Temsirolimus MTOR 6 38 -1.6094379124341 NA -1.12423691212419 -1.84989422969283 0.725657317568644 0.964800999663267 1.54656062380014 0.48725760512155 0.752131597937721 0.469207159681585 0.273665935055929 NA NA NA 0.152313682550588 97.3130109272077 a3249 loss_cnaBRCA7_(FAS,PTEN) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 4 42 2.30258509299405 NA 1.93709447186678 1.36327781465844 0.57381665720834 0.552610048626036 1.01392560881425 0.580005751648975 1.03837535823865 0.565935658612465 0.273698631409095 NA NA NA 0.128373229425633 97.3130109272077 a3250 PTEN_mut 194 AUY922 HSP90 8 39 -1.36257783450257 NA -3.00673274480299 -2.26800642455852 -0.738726320244469 1.0225427378387 1.81695810063333 0.430070774665358 0.722440532711502 0.406573117997037 0.273717893173399 NA NA NA 0.129170231004851 97.3130109272077 a3251 gain_cnaBRCA14_(RAD21) 87 GW843682X PLK1 6 6 -1.36257783450257 NA -2.54270054860957 -1.28670393302683 -1.25599661558273 1.92269671023949 1.83339691447747 0.668589191636257 0.653247394086554 0.685065304552833 0.273760838433204 NA NA NA 0.27381990399202 97.3130109272077 a3252 gain_cnaBRCA16 134 Etoposide TOP2 16 31 2.77258872223978 NA 2.95997719960602 2.22787563101316 0.73210156859286 2.40453051774498 2.00544035597213 0.341031042217854 0.304467572022933 0.36505776220803 0.273807794326747 NA NA NA 0.305771752579119 97.3130109272077 a3253 gain_cnaBRCA16 295 NVP-BHG712 EPHB4 16 33 2.32630161961136 NA 4.16429972572031 3.75211844701655 0.412181278703758 1.39564280652554 1.13188571218288 0.337227953800352 0.295334362615235 0.364154502762344 0.27393317379421 NA NA NA 0.313531911497151 97.3130109272077 a3254 loss_cnaBRCA28_(GPS2) 1023 GW 441756 NTRK1 3 42 0.693147180559945 NA 3.15848871398633 2.30220093924531 0.856287774741012 0.52562386351123 1.32000410080172 0.661780014370348 1.62908846836007 0.648700844354146 0.27429033888211 NA NA NA 0.0765210499638437 97.3130109272077 a3255 POLR2B_mut 298 OSI-930 KIT, VEGFR, PDGFR 3 45 2.32630161961136 NA 3.37596994481806 3.94919378655051 -0.573223841732442 0.531528925373823 0.881292016427837 0.659623200876505 1.07844336285047 0.650435759143609 0.27438242669302 NA NA NA 0.191074173405143 97.3130109272077 a3256 gain_cnaBRCA30_(CRNKL1,FOXA2) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 38 -1.38629436111989 0.693147180559945 0.58583842874875 -0.395719600135434 0.981558028884184 1.69891362695411 1.68380366985417 0.582547204652752 0.577756286906689 0.58294090128049 0.27438363540712 NA NA NA 0.3385310470122 97.3130109272077 a3257 PTEN_mut 192 LFM-A13 BTK 8 40 2.77258872223978 NA 4.49839138048261 4.85488587301789 -0.356494492535276 0.692359455956931 0.854798020909358 0.428413481214128 0.51489799044133 0.417051144030525 0.27440935372886 NA NA NA 0.227024511021553 97.3130109272077 a3258 gain_cnaBRCA16 301 PHA-793887 CDK-pan 16 32 2.32630161961136 NA 2.55365385448224 3.10657793197878 -0.552924077496532 1.87422965647909 1.50183214110996 0.338671565248386 0.295014047816984 0.368166363178165 0.274435968385787 NA NA NA 0.314419422169362 97.3130109272077 a3259 gain_cnaBRCA30_(CRNKL1,FOXA2) 290 KIN001-260 IKK 5 44 2.99573227355399 NA 5.5295472930291 4.98890617387322 0.540641119155876 1.35580841291909 1.00137506763606 0.521718424953354 0.39875923028967 0.539898721896648 0.274580081082473 NA NA NA 0.430519532259736 97.3130109272077 a3260 gain_cnaBRCA12_(TERT) 1175 AG-014699 PARP1, PARP2 10 33 1.6094379124341 NA 4.17446062522965 3.7667555041055 0.407705121124144 0.685644622441305 1.09586657723399 0.399691551160212 0.594630378157813 0.372039014232198 0.274637639475116 NA NA NA 0.170732440758415 97.3130109272077 a3261 loss_cnaBRCA57 194 AUY922 HSP90 5 42 -1.36257783450257 NA -1.59070494718923 -2.48934732810143 0.898642380912198 1.21212783707246 1.75934665547813 0.523142158372919 0.741375912199662 0.510781873551793 0.274685864199383 NA NA NA 0.187068996999738 97.3130109272077 a3262 gain_cnaBRCA8_(CHD4,WNK1) 175 PAC-1 CASP3 agonist 3 45 0.940007258491471 NA 3.1526390122582 2.3512979864301 0.801341025828098 0.626127777688836 1.23602306380482 0.65906040008365 1.2798362480994 0.64832206557809 0.274786769360253 NA NA NA 0.137970513955471 97.3130109272077 a3263 NF1_mut 279 BIX02189 MAP2K5 (MEK5) 5 44 2.99573227355399 NA 5.44649426210911 4.97972670164026 0.466767560468851 0.456226139550087 0.925441706036008 0.521448952502247 1.02310569256106 0.504372730799199 0.274824897601924 NA NA NA 0.0937211487404324 97.3130109272077 a3264 gain_cnaBRCA15 1033 Vismodegib SMO 21 24 2.30258509299405 NA 4.89687205220547 4.63981427247374 0.257057779731729 0.746680947370625 0.803791125140389 0.330514631782781 0.344267227705404 0.31980669068327 0.274827531723913 NA NA NA 0.272478040372111 97.3130109272077 a3265 PTEN_mut 133 Doxorubicin DNA intercalating 8 40 0.0237165266173161 NA -1.68153932983121 -0.90046611427449 -0.781073215556722 1.81662774516621 1.8264845774561 0.427988123932412 0.429957770729336 0.427637454593014 0.274879923261875 NA NA NA 0.293222238157514 97.3130109272077 a3266 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 6 40 0 NA 1.51505795198561 0.523938724436813 0.991119227548794 1.26816103428809 2.12709358699417 0.484012678428139 0.781540514770018 0.465949986220099 0.27492436948113 NA NA NA 0.139847404207548 97.3130109272077 a3267 BRCA1_mut 274 PXD101, Belinostat HDAC 4 44 2.99573227355399 NA 1.45829829976539 0.599976531984093 0.858321767781294 0.89006313319028 1.52040775546077 0.577037328072398 0.964338074204675 0.564533931570992 0.274930612071046 NA NA NA 0.14977996242794 97.3130109272077 a3268 gain_cnaBRCA16 282 EKB-569 EGFR 15 32 0.916290731874155 2.99573227355399 1.08270037169971 1.81027077097995 -0.72757039928024 2.45450224934109 1.92473837091488 0.345820287428559 0.296422787746703 0.37801002477776 0.274967530572001 NA NA NA 0.322590365839613 97.3130109272077 a3269 gain_cnaBRCA8_(CHD4,WNK1) 170 Shikonin unknown 3 44 2.77258872223978 NA 0.732055175413453 -0.0460588452735893 0.778114020687043 1.02439368706007 1.18669682203685 0.659442411595323 0.759584943285005 0.655697399906647 0.274975432553803 NA NA NA 0.317229254740654 97.3130109272077 a3270 TP53_mut 265 Tubastatin A HDAC6 38 11 2.99573227355399 NA 4.77914371301535 4.38988673435828 0.389256978657077 0.96794799370826 1.23058164543582 0.378119744536242 0.402146583481012 0.316319506390181 0.275049299454031 NA NA NA 0.350613514217713 97.3130109272077 a3271 gain_cnaBRCA15 1219 PFI-1 BRD2, BRD3, BRD4 22 25 2.30258509299405 NA 3.34296119661965 3.02245854435623 0.320502652263416 1.20781114301529 0.754817446738434 0.322992297238819 0.265358250846471 0.424609491537732 0.275073950714847 NA NA NA 0.29042688756255 97.3130109272077 a3272 loss_cnaBRCA24 1373 Dabrafenib BRAF 3 43 2.30258509299405 NA 5.21745574947855 4.14462169307382 1.07283405640472 0.152438238364523 1.66358297034443 0.659937752002059 7.03782769936813 0.64489362750726 0.27510375748303 NA NA NA 0.000266503748854981 97.3130109272077 a3273 loss_cnaBRCA34 1020 Lenalidomide TNFA 5 40 1.6094379124341 NA 3.92563117130404 4.29586350258166 -0.370232331277613 0.529102432060514 0.721800022693391 0.524336662556166 0.69973658944601 0.512929231972166 0.275133515591197 NA NA NA 0.208064731311496 97.3130109272077 a3274 loss_cnaBRCA22_(SYNCRIP,ZNF292) 202 GSK-1904529A IGF1R 18 30 0.0237165266173161 NA 2.36012813818682 2.08740219693214 0.272725941254678 0.814570842384462 0.836188669490381 0.329273691507866 0.334809358577503 0.326153595720081 0.275155711007581 NA NA NA 0.273443471577837 97.3130109272077 a3275 CDH1_mut 1378 Bleomycin (50 uM) DNA damage 5 43 3.91202300542815 NA 4.68921964253931 3.71079877254638 0.978420869992935 2.15253129804136 1.84709173232516 0.521649945554521 0.454544317605614 0.529708867659364 0.275325389242939 NA NA NA 0.376708222379352 97.3432880013432 a3276 PIK3CA_mut 29 AZ628 BRAF 4 10 1.38629436111989 NA 3.45514945378333 2.09846281793811 1.35668663584522 0.821595524446713 2.27047436399844 0.675391119702231 1.65128289465653 0.59753444361997 0.2758817950407 NA NA NA 0.126918951879837 97.4871493195702 a3277 POLR2B_mut 1133 JNJ-26854165 MDM2 3 40 2.30258509299405 NA 3.50193469252441 2.92883186247187 0.57310283005254 1.14906764150366 0.849976230480296 0.661046271670026 0.498754650598796 0.67425747862231 0.275900672182599 NA NA NA 0.480327104453481 97.4871493195702 a3278 ASH1L_mut 253 XMD14-99 EPHB3, CAMK1 3 45 2.32630161961136 NA 4.45931313732491 4.96468775374951 -0.505374616424598 0.357075483771881 0.782463010898112 0.657288937004615 1.41531591888134 0.645876686035968 0.276062214408261 NA NA NA 0.110311614749131 97.5144716483604 a3279 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1017 Olaparib PARP1, PARP2 15 30 1.6094379124341 NA 4.27967097196542 3.97131166074398 0.308359311221444 0.851770098468893 0.899483827509139 0.348731291045951 0.362021761242544 0.342818071643774 0.276254386337566 NA NA NA 0.270295750609428 97.532745268212 a3280 gain_cnaBRCA63 271 VNLG/124 HDAC, RAR 7 42 1.63315443905142 NA 4.46320348858704 4.09947954180462 0.363723946782412 0.870613344515203 0.799426526418497 0.449673047158754 0.417778970508372 0.454981083017007 0.276301314687115 NA NA NA 0.33175330792427 97.532745268212 a3281 BRCA1_mut 305 TPCA-1 IKK 4 45 2.99573227355399 NA 4.90304515107232 4.11390691806622 0.789138233006095 0.776297412951138 1.40514611015972 0.574488887538645 1.01654110891101 0.561605819708239 0.276467983131898 NA NA NA 0.133923489637508 97.532745268212 a3282 gain_cnaBRCA47_(EGFR) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 7 42 1.63315443905142 NA 3.19352444256492 3.640512307465 -0.446987864900074 0.99162097357074 0.995096348777315 0.449390594626944 0.450764835369012 0.449190538634066 0.276599285694105 NA NA NA 0.301288978550689 97.532745268212 a3283 gain_cnaBRCA14_(RAD21) 306 TG101348 JAK2 21 27 2.32630161961136 NA 3.45484237664272 3.04603625222388 0.408806124418848 1.45704427709506 1.11729372959802 0.320337262659301 0.280572204184414 0.365889571908659 0.276634451435257 NA NA NA 0.293828027306654 97.532745268212 a3284 ARID1A_mut 1050 ZM-447439 AURKB 4 35 1.38629436111989 0.693147180559945 2.20390642883868 2.96609752758426 -0.762191098745586 1.13191773961113 1.32250572867806 0.58267591292304 0.673362623513114 0.576323476123958 0.27673265492341 NA NA NA 0.278591681664403 97.532745268212 a3285 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 196 Phenformin AAPK1 (AMPK) agonist 6 42 8.29404964010203 NA 6.4451883047779 7.31013090966081 -0.864942604882912 2.11407734278676 1.75990543015745 0.480049511459034 0.409134797188995 0.491471070013989 0.277085042389685 NA NA NA 0.375817086235281 97.532745268212 a3286 gain_cnaBRCA10_(MDM2,NUP107) 1114 Cetuximab EGFR 3 42 4.18661983833127 NA 6.81838068781734 6.24431393851277 0.574066749304567 0.317217060856756 0.890922271377201 0.65784888350917 1.80969695562433 0.644351104184617 0.277111469075569 NA NA NA 0.0559044850170615 97.532745268212 a3287 BRCA2_mut 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 5 40 2.30258509299405 NA 1.87394467721342 1.30174643259547 0.572198244617942 0.708905326760246 1.12811004596878 0.522126415667387 0.807157490596007 0.507218463892465 0.277134107848995 NA NA NA 0.160572300708585 97.532745268212 a3288 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1053 MK-2206 AKT1, AKT2 8 34 1.38629436111989 0.693147180559945 1.96674542782542 1.25908696461413 0.707658463211281 1.97322926949341 1.55318421335667 0.432950210684494 0.358629620060804 0.455617857254628 0.277139799182901 NA NA NA 0.367674021586376 97.532745268212 a3289 NF1_mut 301 PHA-793887 CDK-pan 4 44 2.32630161961136 NA 3.78192883099274 2.84411909479695 0.937809736195791 0.599841804765078 1.68141963617481 0.574332940025644 1.56342843854152 0.557748771347341 0.277157377984046 NA NA NA 0.0421829141836443 97.532745268212 a3290 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 9 40 1.63315443905142 NA 3.24733914928003 3.6507533916991 -0.403414242419068 1.14743268600857 0.960356116290987 0.405569116278446 0.35157987683127 0.420067343327914 0.277234404674476 NA NA NA 0.348645345773964 97.532745268212 a3291 loss_cnaBRCA17 1502 Bicalutamide ANDR (androgen receptor) 9 36 2.30258509299405 NA 4.74864195787885 4.51071842671647 0.237923531162384 0.421167306989708 0.610676133458789 0.410124504711546 0.564914529722028 0.389606729535697 0.277245870585722 NA NA NA 0.187354253492308 97.532745268212 a3292 ASH1L_mut 1039 SL 0101-1 RSK, AURKB, PIM3 3 40 2.30258509299405 NA 4.06120007630629 4.69290048036954 -0.631700404063248 1.11169786110875 0.94989544595651 0.659104523570843 0.568230295444866 0.665020983890653 0.277293200987092 NA NA NA 0.430142635327637 97.532745268212 a3293 gain_cnaBRCA10_(MDM2,NUP107) 225 Genentech Cpd 10 AURKA, AURKB 5 44 2.32630161961136 NA 3.76556829397546 2.93311971426393 0.83244857971153 1.43872060523601 1.61985879857335 0.518582412846685 0.578603362377627 0.513901940369548 0.27743868100458 NA NA NA 0.27829547272963 97.5542814258133 a3294 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1268 XAV 939 TNKS1 (tankyrase-1) 15 32 1.6094379124341 NA 3.88014133837518 3.55892769235784 0.321213646017334 0.913246526969045 0.943362422363334 0.34387608164518 0.351727202383571 0.340498665626963 0.277639481173123 NA NA NA 0.275410848249955 97.595250531378 a3295 gain_cnaBRCA64_(SDHC) 1114 Cetuximab EGFR 8 37 4.18661983833127 NA 5.97503219969663 6.34908296982204 -0.374050770125413 0.4787136378195 0.930097854010035 0.428625718580842 0.78136643825144 0.402162813850957 0.277752322492948 NA NA NA 0.116324004142422 97.6030864467995 a3296 gain_cnaBRCA62 1058 GDC0941 PI3K (class 1) 7 36 1.38629436111989 0.693147180559945 1.87018727857636 1.24407776501165 0.626109513564709 0.821714674793898 1.45229414595376 0.454309732466345 0.761954888686574 0.431117563414487 0.277830359209475 NA NA NA 0.133261402944758 97.6030864467995 a3297 gain_cnaBRCA61_(NOTCH2) 328 SNX-2112 HSP90 3 45 0.940007258491471 NA 1.66257409835132 0.334217680653264 1.32835641769806 1.89840435420328 2.0346669639108 0.654706954680906 0.699722593217262 0.652861839927281 0.277928688918239 NA NA NA 0.348856516795669 97.6080160444128 a3298 loss_cnaBRCA60 286 KIN001-236 TIE2 3 46 2.32630161961136 NA 5.00840909273441 4.50956235387694 0.49884673885747 0.155893101507429 0.779091954626044 0.65378510732915 3.19992824591855 0.640292504492504 0.278153841777713 NA NA NA 0.00489330327729508 97.6574691917568 a3299 loss_cnaBRCA24 200 LAQ824 HDAC 3 45 0.0237165266173161 NA -3.54509079248517 -2.62709251771164 -0.917998274773527 0.35792706963824 1.43273584120695 0.65420397471 2.56476347458535 0.640731004537581 0.278293315623506 NA NA NA 0.0146172911748127 97.6768202971984 a3300 gain_cnaBRCA27_(CLTC,PPM1D) 1049 PD-173074 FGFR1, FGFR3 10 33 0.693147180559945 NA 3.28341146462402 2.8330223308917 0.450389133732317 0.909341045905479 1.19185903804304 0.396511766939272 0.49529176733009 0.377887920766057 0.278418536190049 NA NA NA 0.219101325252989 97.6911585013508 a3301 gain_cnaBRCA14_(RAD21) 52 GNF-2 ABL [T315I] 6 6 0.246860077931526 NA 2.30474524842791 2.66893034474356 -0.364185096315648 0.652901242413173 0.424035306718493 0.661561236287732 0.557795073217493 0.858855596563382 0.278534645472792 NA NA NA 0.282803170512376 97.7017739442416 a3302 NF1_mut 225 Genentech Cpd 10 AURKA, AURKB 5 44 2.32630161961136 NA 2.27237682723622 3.10280056275703 -0.830423735520813 1.00895842350367 1.64989305920667 0.517288731154403 0.823050500571782 0.503319733898459 0.278623998679771 NA NA NA 0.152686499594559 97.7017739442416 a3303 loss_cnaBRCA18 94 TGX221 PI3Kbeta 6 8 2.30258509299405 NA 3.33110283954672 4.09771762853599 -0.766614788989268 1.42867210053238 1.1070602473478 0.612726804780832 0.536592538416334 0.69247793047023 0.278719467630086 NA NA NA 0.302890874206436 97.7017739442416 a3304 BRCA1_mut 206 Ruxolitinib JAK1, JAK2, TYK2 4 45 1.65632149833295 0.0237165266173161 4.71153595844943 4.33992485178704 0.371611106662388 0.18200453931598 0.670135001568143 0.571688703442841 2.04176834302593 0.554531707481034 0.278786303749697 NA NA NA 0.0162803807016428 97.7017739442416 a3305 CDH1_mut 268 YM155 BIRC5 (Survivin) 4 45 1.63315443905142 NA -4.43001236512254 -3.52140605858608 -0.908606306536461 0.975210031624548 1.62344127510488 0.571457449534852 0.931703199384511 0.559679195342474 0.278978371299971 NA NA NA 0.160473904693855 97.7235450964464 a3306 gain_cnaBRCA27_(CLTC,PPM1D) 1264 SGC0946 Q8TEK3 (DOT1L) 10 36 -0.693147180559945 NA 2.13574030790976 1.8993173731576 0.236422934752161 0.620633134467267 0.599126834548749 0.391695757616953 0.380938305775601 0.39461249458177 0.279139127558959 NA NA NA 0.301107224508079 97.7235450964464 a3307 PTEN_mut 271 VNLG/124 HDAC, RAR 9 40 1.63315443905142 NA 3.88471182021276 4.21145396984971 -0.326742149636953 0.629601841957593 0.841067997070937 0.403890554050002 0.518966317857375 0.388484820222443 0.27920269554979 NA NA NA 0.207956317906318 97.7235450964464 a3308 gain_cnaBRCA27_(CLTC,PPM1D) 192 LFM-A13 BTK 9 39 2.77258872223978 NA 4.52166543545177 4.85865582167976 -0.336990386227984 0.627805511730353 0.869297196353178 0.404867682818203 0.536775131679194 0.387658429869215 0.279291415635093 NA NA NA 0.198728432441477 97.7235450964464 a3309 gain_cnaBRCA13_(FGFR1,WHSC1L1) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 11 36 2.32630161961136 NA 0.976516220639661 1.55150907079466 -0.574992850154999 1.10954197944923 1.62358637755516 0.377190752678231 0.518225412652184 0.354149836500131 0.27940241018239 NA NA NA 0.193780071813617 97.7235450964464 a3310 gain_cnaBRCA64_(SDHC) 308 XL-880 MET 8 41 1.63315443905142 NA 2.41244535753664 1.73754068697056 0.674904670566078 1.99870441401358 1.51462396233034 0.422858449124802 0.337671076240238 0.445592231043074 0.279512110810509 NA NA NA 0.389667583817405 97.7235450964464 a3311 loss_cnaBRCA17 52 GNF-2 ABL [T315I] 3 9 0.246860077931526 NA 2.80156681877008 2.38192812252429 0.41963869624579 0.212958980346226 0.60636228211124 0.762085021267303 1.97051420683714 0.692059365540823 0.279614264110943 NA NA NA 0.107425797019809 97.7235450964464 a3312 gain_cnaBRCA14_(RAD21) 1067 CCT007093 PPM1D 21 25 1.88706964903238 NA 4.25825177584914 3.94063916027424 0.317612615574901 0.993488746523238 0.96900039209136 0.324025962041917 0.31969422571358 0.32777346445589 0.279620485654282 NA NA NA 0.280918054075799 97.7235450964464 a3313 gain_cnaBRCA64_(SDHC) 1203 QL-XII-61 BTK 6 17 2.30258509299405 NA 4.80621363070971 4.02015129949086 0.786062331218852 1.38464669857128 1.52389594235135 0.526879437709972 0.567698844788303 0.515824151356404 0.279737189837149 NA NA NA 0.27247680720579 97.7235450964464 a3314 gain_cnaBRCA58_(CCND1) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 9 37 0 NA -0.0167965321476469 0.816190958884189 -0.832987491031836 1.49533749340454 2.15194729657388 0.406676562463572 0.557056513800984 0.387085451561958 0.279826096843825 NA NA NA 0.190600329916907 97.7235450964464 a3315 gain_cnaBRCA14_(RAD21) 308 XL-880 MET 21 28 1.63315443905142 NA 2.13558255951118 1.63183918844112 0.503743371070063 1.76626429711624 1.4572592467939 0.315612912514976 0.285202713938407 0.345678623881334 0.279827575025604 NA NA NA 0.294266602699546 97.7235450964464 a3316 gain_cnaBRCA14_(RAD21) 154 CHIR-99021 GSK3B 21 26 0.940007258491471 NA 3.43537646472096 3.14625487022707 0.289121594493887 0.821037837495451 0.960387144773874 0.320847498090715 0.352141620386026 0.301046922657385 0.279963741169609 NA NA NA 0.27197561617439 97.7235450964464 a3317 gain_cnaBRCA31 1058 GDC0941 PI3K (class 1) 13 30 1.38629436111989 0.693147180559945 0.996457087169113 1.49747227857518 -0.50101519140607 1.41042320804003 1.36484212840713 0.363492002826515 0.355223303580133 0.367086552340519 0.280039957930178 NA NA NA 0.291636681599638 97.7235450964464 a3318 loss_cnaBRCA18 300 CX-5461 RNA Pol I 16 33 2.32630161961136 NA 3.53141475953349 4.09706858228565 -0.565653822752158 1.8786306117122 1.60826772314859 0.33288756735393 0.301099012879715 0.351716206580797 0.280077878138679 NA NA NA 0.31040743506569 97.7235450964464 a3319 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1031 Elesclomol HSP70 7 37 -1.6094379124341 NA -2.30455957611395 -3.10490708303554 0.80034750692159 2.44296242503132 1.63737705850844 0.450902945947691 0.327613514936206 0.488798534682452 0.280201441081419 NA NA NA 0.432590404201274 97.7235450964464 a3320 gain_cnaBRCA10_(MDM2,NUP107) 150 Bicalutamide ANDR (androgen receptor) 4 44 0.0237165266173161 NA 3.08680291051801 2.73311363735586 0.353689273162149 0.258325153043184 0.637827030403204 0.570286014216436 1.36916312250485 0.554522239263775 0.280513230212599 NA NA NA 0.063553344563458 97.7235450964464 a3321 gain_cnaBRCA14_(RAD21) 299 OSI-027 MTORC1/2 21 27 2.99573227355399 NA 0.916113810242513 1.54341292737661 -0.627299117134098 1.88096931853275 2.04359145077016 0.317694996117798 0.333497793373591 0.306959160989683 0.280564790347654 NA NA NA 0.275726848071867 97.7235450964464 a3322 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 136 Mitomycin C DNA crosslinker 6 42 2.77258872223978 NA -0.747392381823415 -0.046721414844482 -0.700670966978933 1.32577941047166 1.48763043996909 0.476354984651937 0.528497396659419 0.470998003370712 0.2807517014855 NA NA NA 0.272534198893555 97.7235450964464 a3323 gain_cnaBRCA19 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 4 44 2.32630161961136 NA 4.59680122456012 4.99137123792419 -0.394570013364063 1.27268003723059 0.632146728346149 0.569998919198818 0.310030802575221 0.624174729807357 0.280752377767385 NA NA NA 0.581350685672353 97.7235450964464 a3324 BRCA1_mut 1061 SB590885 BRAF 4 38 1.6094379124341 NA 4.5742142753987 3.95272195125861 0.621492324140096 0.339303086853033 1.12018572711848 0.574732142841411 1.83167306228868 0.554811857618286 0.280777393177758 NA NA NA 0.0272275509132562 97.7235450964464 a3325 loss_cnaBRCA36_(FAT1,IRF2) 341 EX-527 SIRT1 9 40 2.99573227355399 NA 5.42783133028019 5.68988566820739 -0.262054337927198 0.492483410417446 0.679220747491005 0.402400194657227 0.532107950001954 0.38581615608064 0.280958501605037 NA NA NA 0.200611960663413 97.7235450964464 a3326 TP53_mut 1218 JQ1 BRD2, BRD3, BRD4 36 10 0 NA 2.51720974877404 2.24476151564711 0.272448233126926 0.623931383251364 0.932538611920301 0.390191935154174 0.436663774960594 0.292157589663655 0.280964501029878 NA NA NA 0.401673020305845 97.7235450964464 a3327 gain_cnaBRCA19 1017 Olaparib PARP1, PARP2 4 41 1.6094379124341 NA 3.61320562635352 4.11906321698504 -0.505857590631519 0.850723386705096 0.886951460299439 0.571931670124307 0.594620529465797 0.570332891115304 0.280982499655248 NA NA NA 0.326632215066233 97.7235450964464 a3328 gain_cnaBRCA62 261 TL-1-85 MAP3K7 (TAK1) 10 39 2.32630161961136 NA 3.65386509469524 4.11991963805744 -0.466054543362195 1.60415678048197 1.09031205719601 0.386517143987905 0.290529298029192 0.427450600299479 0.281077056890372 NA NA NA 0.403197096164472 97.7235450964464 a3329 gain_cnaBRCA48 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 41 1.38629436111989 NA 2.1798095412486 2.94138969552028 -0.761580154271683 0.988218341139802 1.51322847330439 0.51693821307702 0.770659805193743 0.503281670750381 0.281089081304553 NA NA NA 0.175230086316867 97.7235450964464 a3330 gain_cnaBRCA64_(SDHC) 1264 SGC0946 Q8TEK3 (DOT1L) 9 37 -0.693147180559945 NA 2.14762046417113 1.9028174144657 0.244803049705428 0.686069588371202 0.583764275066167 0.405533862397104 0.356819561535464 0.419352571168698 0.281161585116996 NA NA NA 0.344843278798403 97.7235450964464 a3331 loss_cnaBRCA33 257 NPK76-II-72-1 PLK3 6 43 2.32630161961136 NA 2.82157361755769 3.57068867095368 -0.749115053395991 1.55319068509558 1.5794530738315 0.475121809973375 0.482307201932447 0.474287628931424 0.281171414810301 NA NA NA 0.308435466440651 97.7235450964464 a3332 NF1_mut 1008 Methotrexate Dihydrofolate reductase (DHFR) 4 41 -1.6094379124341 NA 1.2468867301351 0.627602595844961 0.619284134290137 0.633586054139487 1.10996241338305 0.571535471663474 0.977427028647633 0.55793252710479 0.281311383184908 NA NA NA 0.146656192715682 97.7235450964464 a3333 loss_cnaBRCA7_(FAS,PTEN) 253 XMD14-99 EPHB3, CAMK1 4 44 2.32630161961136 NA 5.33444027069282 4.89661652836208 0.437823742330739 0.215520642969854 0.7934330283124 0.569270643724934 2.03147010094981 0.551809323166156 0.281359665964898 NA NA NA 0.0170375786923121 97.7235450964464 a3334 gain_cnaBRCA19 269 NSC-207895 MDM4 4 45 2.99573227355399 NA 3.98686603488434 4.65879363190482 -0.671927597020476 1.62260300013845 1.14572350994803 0.568502519239317 0.414104742172388 0.586465749534069 0.281440762432702 NA NA NA 0.472480825120233 97.7235450964464 a3335 gain_cnaBRCA12_(TERT) 1502 Bicalutamide ANDR (androgen receptor) 9 36 2.30258509299405 NA 4.36960444927019 4.60547780386864 -0.235873354598442 0.410835682913836 0.612445875870856 0.406492265829639 0.574130642512644 0.385133387114488 0.281464740389195 NA NA NA 0.184115477317291 97.7235450964464 a3336 loss_cnaBRCA28_(GPS2) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 3 42 2.30258509299405 NA 2.03208834446742 1.31769799182104 0.714390352646382 1.58637243058732 1.06651769868394 0.651710498980949 0.450329530992854 0.669834503007242 0.281557424675307 NA NA NA 0.51859699002093 97.7264214722836 a3337 loss_cnaBRCA57 312 AV-951 VEGFR 5 43 -2.05572501506252 NA 0.926419221197362 0.598073130651675 0.328346090545687 0.377115978469398 0.657814085791607 0.514387365193575 0.870676686462202 0.499147247889286 0.281978427797659 NA NA NA 0.136741211188115 97.72764725174 a3338 loss_cnaBRCA57 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 5 21 2.30258509299405 NA 3.23062533840613 2.56318957268932 0.667435765716806 0.474175490105667 1.31871969946219 0.547398843307206 1.40757120442491 0.50612405804585 0.282222957228646 NA NA NA 0.0771897134157854 97.72764725174 a3339 POLR2B_mut 274 PXD101, Belinostat HDAC 3 45 2.99573227355399 NA 1.57611162415817 0.611196127419714 0.964915496738458 1.66473069589157 1.47953594391575 0.648435419364152 0.579622577465412 0.652174420436658 0.28249918126144 NA NA NA 0.422277315993803 97.72764725174 a3340 gain_cnaBRCA64_(SDHC) 206 Ruxolitinib JAK1, JAK2, TYK2 8 41 1.65632149833295 0.0237165266173161 4.59885452426618 4.32565673097768 0.273197793288502 0.816124067353709 0.61652663981581 0.420207883787417 0.334750320713307 0.443124069010418 0.2824996388554 NA NA NA 0.393490444745233 97.72764725174 a3341 gain_cnaBRCA62 271 VNLG/124 HDAC, RAR 10 39 1.63315443905142 NA 4.39957248616462 4.08781641831429 0.311756067850327 0.731912872913023 0.826360664426456 0.385298446830164 0.425946966350699 0.377263925149081 0.282577967783871 NA NA NA 0.259983968466059 97.72764725174 a3342 loss_cnaBRCA17 152 CP466722 ATM 11 38 2.77258872223978 NA 2.42539198174723 2.81835880194645 -0.392966820199217 0.981889873811902 1.07519018931549 0.37211722984037 0.400214760005252 0.365485868550748 0.282645445618981 NA NA NA 0.268111992662417 97.72764725174 a3343 gain_cnaBRCA27_(CLTC,PPM1D) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 9 37 1.63315443905142 NA 2.45148056699526 1.81135253224001 0.640128034755254 1.21547920492752 1.65438780669788 0.404207984318455 0.52664663628978 0.386927437547388 0.282716756658211 NA NA NA 0.207982541084509 97.72764725174 a3344 gain_cnaBRCA47_(EGFR) 225 Genentech Cpd 10 AURKA, AURKB 7 42 2.32630161961136 NA 2.40750117454414 3.11982382561146 -0.71232265106732 1.23907835833171 1.65252342820823 0.443626262622961 0.574881036600774 0.431051468867624 0.282729745386768 NA NA NA 0.211336359448206 97.72764725174 a3345 gain_cnaBRCA64_(SDHC) 175 PAC-1 CASP3 agonist 8 40 0.940007258491471 NA 2.82809205066211 2.31603975052081 0.512052300141301 1.34213979398644 1.19243218355416 0.420956153239034 0.381519348756063 0.429418383035484 0.282741874648536 NA NA NA 0.341202873030583 97.72764725174 a3346 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 290 KIN001-260 IKK 6 43 2.99573227355399 NA 4.61337274868729 5.10417143310334 -0.490798684416052 0.75877455250735 1.06498959711806 0.473414136997115 0.646830712487946 0.460848336682527 0.282882834136556 NA NA NA 0.197902757464499 97.72764725174 a3347 loss_cnaBRCA28_(GPS2) 1006 Cytarabine DNA synthesis 3 42 0.693147180559945 NA 2.13054821216855 1.14267506498151 0.987873147187049 1.60749973882407 1.51566632955012 0.6498906002236 0.614540160304911 0.651774818722976 0.282885133048566 NA NA NA 0.399565112513149 97.72764725174 a3348 gain_cnaBRCA8_(CHD4,WNK1) 299 OSI-027 MTORC1/2 4 44 2.99573227355399 NA 0.242239481979362 1.36230866196236 -1.120069179983 2.32139310368514 1.94831748195136 0.567181625678333 0.482498710883962 0.574890483896485 0.283106744982755 NA NA NA 0.411159325303943 97.72764725174 a3349 loss_cnaBRCA23 184 BMS-754807 IGF1R 3 45 0.940007258491471 NA 2.63971001131239 1.55934621757104 1.08036379374135 0.292220390949774 1.70649968485421 0.646885105038547 3.69708558061248 0.633087602259738 0.283637068834735 NA NA NA 0.00245422404274459 97.72764725174 a3350 gain_cnaBRCA62 346 THZ-2-102-1 CDK7 10 38 0.916290731874155 2.99573227355399 -0.562436301248726 -1.53850535905513 0.976069057806407 3.37902367270973 2.27843771811239 0.385538801758199 0.288861266551492 0.428394004386061 0.283674449796129 NA NA NA 0.406025816140032 97.72764725174 a3351 gain_cnaBRCA14_(RAD21) 32 VX-680 AURKA, AURKB, AURKC, FLT3, ABL1, JAK2 6 6 0.693147180559945 NA 0.503045715302879 1.87923676809667 -1.37619105279379 2.4643269919854 1.66820171867394 0.654002965538849 0.558444986103512 0.824954822542523 0.283741431972859 NA NA NA 0.287273381185796 97.72764725174 a3352 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1016 Temsirolimus MTOR 16 28 -1.6094379124341 NA -1.42826563050826 -1.93532686117645 0.507061230668189 1.35078435795953 1.56221763352789 0.340274479409873 0.375382811979069 0.324577843564033 0.283768926295215 NA NA NA 0.265925207522309 97.72764725174 a3353 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 299 OSI-027 MTORC1/2 14 34 2.99573227355399 NA 0.78722602410037 1.46733455049577 -0.680108526395397 1.78679343189068 2.04421553249358 0.34438138119266 0.380630751298288 0.332699030794363 0.283802273709498 NA NA NA 0.26079843239181 97.72764725174 a3354 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1030 KU-55933 ATM 6 36 2.30258509299405 NA 4.59868490566407 4.15956842994519 0.439116475718882 1.18403155727898 0.87210218240771 0.478906368705244 0.370865517071197 0.503514937328289 0.283955428912837 NA NA NA 0.418099728475033 97.72764725174 a3355 loss_cnaBRCA57 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 38 1.6094379124341 NA 3.29484754470912 2.47161690465451 0.823230640054617 1.26612444487563 1.62580439760648 0.516361972553182 0.650197256191104 0.506352819113163 0.284077758686505 NA NA NA 0.236430836433733 97.72764725174 a3356 gain_cnaBRCA30_(CRNKL1,FOXA2) 224 AS605240 PI3Kgamma 5 44 2.99573227355399 2.32630161961136 2.54798351113815 3.35233325366315 -0.804349742524997 1.4134273803305 1.58691502375389 0.51138162827694 0.56907751591519 0.506863776878417 0.284081466850073 NA NA NA 0.28531677787445 97.72764725174 a3357 TP53_mut 1164 XMD8-92 MAP2K5 (ERK5) 23 3 2.30258509299405 NA 3.7844312008412 4.65159867868808 -0.867167477846877 1.32625188973616 0.774483279915421 0.672576436703207 0.653848250515509 1.11967230324401 0.28409710403304 NA NA NA 0.178695965837167 97.72764725174 a3358 gain_cnaBRCA63 298 OSI-930 KIT, VEGFR, PDGFR 7 41 2.32630161961136 NA 4.2425091511451 3.8571723456393 0.385336805505799 0.710589920586856 0.890863045234705 0.443185121715805 0.542277330907762 0.43254325967049 0.28414938744901 NA NA NA 0.232813900618606 97.72764725174 a3359 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1049 PD-173074 FGFR1, FGFR3 8 35 0.693147180559945 NA 2.54445032644846 3.02766425583082 -0.483213929382362 1.78649830805245 0.948594831968761 0.425263955571149 0.270481045072546 0.509399706911196 0.284179940298598 NA NA NA 0.479776447817973 97.72764725174 a3360 loss_cnaBRCA24 273 CUDC-101 HDAC, EGFR 3 46 1.63315443905142 NA -0.972491671980714 0.0350369122282942 -1.00752858420901 0.504704503906526 1.59169121495098 0.645465509082184 1.99627420879051 0.632992489212199 0.284239056395036 NA NA NA 0.040378072774281 97.72764725174 a3361 loss_cnaBRCA28_(GPS2) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 4 43 2.99573227355399 NA 4.58351885496394 3.77921059287037 0.80430826209357 1.99050377679504 1.37047627336949 0.566311502138663 0.404072713385455 0.586882296120368 0.28442175323083 NA NA NA 0.482373427948152 97.72764725174 a3362 gain_cnaBRCA58_(CCND1) 1018 ABT-888 PARP1, PARP2 9 36 1.6094379124341 NA 4.61661290512034 4.34969201374733 0.266920891373008 0.424544366971616 0.703756876429681 0.403933297681784 0.628723196298713 0.379279976242873 0.284463948827299 NA NA NA 0.161543640906489 97.72764725174 a3363 TP53_mut 263 FR-180204 ERK 38 11 2.99573227355399 NA 5.41856665904697 5.14825695775741 0.270309701289557 0.740621955082518 0.687041342243731 0.370514920682658 0.364976624625501 0.393440226474266 0.284697751823627 NA NA NA 0.274375334121126 97.72764725174 a3364 gain_cnaBRCA8_(CHD4,WNK1) 1018 ABT-888 PARP1, PARP2 3 42 1.6094379124341 NA 4.00384405352756 4.43159277334296 -0.427748719815395 0.520128707673797 0.666920116804824 0.647303764882437 0.822390138257205 0.641379243236378 0.284779909118075 NA NA NA 0.287086773459163 97.72764725174 a3365 gain_cnaBRCA63 1199 Tamoxifen ER 6 41 1.6094379124341 NA 4.26054079413918 3.81189648007199 0.448644314067185 1.22872525124285 0.907093975876171 0.473136939221662 0.365129888568158 0.494595186384999 0.284821597213856 NA NA NA 0.423401991536905 97.72764725174 a3366 POLR2B_mut 1052 RO-3306 CDK1 3 40 1.6094379124341 NA 4.24646573891038 3.4716139322831 0.774851806627273 0.608020904085771 1.21694432701913 0.648702236985503 1.27438349803508 0.636719190371882 0.284837729515527 NA NA NA 0.138269350814589 97.72764725174 a3367 loss_cnaBRCA60 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 3 45 2.32630161961136 NA 4.53971894983684 4.98640850038654 -0.446689550549693 0.775776331826902 0.688350429744295 0.645149793905937 0.575796827286247 0.648927539299463 0.284914536892027 NA NA NA 0.424872417992851 97.72764725174 a3368 gain_cnaBRCA64_(SDHC) 1049 PD-173074 FGFR1, FGFR3 7 36 0.693147180559945 NA 3.36351911216981 2.85497827167993 0.508540840489881 1.11177797343466 1.14047440241619 0.44753304913921 0.457412228557494 0.445902897436799 0.284958721333255 NA NA NA 0.299933230391695 97.72764725174 a3369 loss_cnaBRCA57 1268 XAV 939 TNKS1 (tankyrase-1) 5 42 1.6094379124341 NA 4.08881461140089 3.6105650755732 0.478249535827691 0.270014836612735 0.975358998629658 0.511784158626626 1.77119724911122 0.490331802443626 0.285104024642621 NA NA NA 0.0217149298547983 97.72764725174 a3370 loss_cnaBRCA24 310 YM201636 FYV1 3 46 1.63315443905142 NA 1.80260994550996 2.45458427977484 -0.651974334264876 1.06252052119651 1.00974838125338 0.644211545169447 0.613611051512382 0.645679999462435 0.285164250896005 NA NA NA 0.400042644993727 97.72764725174 a3371 NF1_mut 265 Tubastatin A HDAC6 5 44 2.99573227355399 NA 5.16365871171865 4.6381345821348 0.525524129583843 0.623982746253813 1.05988866796559 0.510218781479626 0.842209392389321 0.495829557827583 0.285164541558861 NA NA NA 0.146318915652783 97.72764725174 a3372 loss_cnaBRCA57 1495 AZD-2281 PARP1, PARP2 5 40 2.30258509299405 NA 4.51152048245997 3.93458764876724 0.576932833692731 0.505430054947953 1.16892185050768 0.513354314981673 1.14146918657645 0.493559799093633 0.285175180205817 NA NA NA 0.0746390000440739 97.72764725174 a3373 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 238 CAL-101 PI3Kdelta 6 43 2.99573227355399 2.32630161961136 5.10770328331004 4.66472155935602 0.442981723954023 0.755415843547447 0.960573068372762 0.470818095786007 0.586407774920065 0.461164005674702 0.285498505286003 NA NA NA 0.233122061344151 97.72764725174 a3374 gain_cnaBRCA12_(TERT) 179 5-Fluorouracil DNA antimetabolite 9 40 3.46573590279973 NA 3.51751381510035 4.15936833446852 -0.641854519368168 1.22722049649293 1.67821462004468 0.398569874852934 0.523014830018253 0.382462714662253 0.285506481488365 NA NA NA 0.207087657255607 97.72764725174 a3375 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 253 XMD14-99 EPHB3, CAMK1 6 42 2.32630161961136 NA 5.25052807749978 4.88775523489771 0.362772842602069 0.488701660275798 0.796749308288475 0.471583909272562 0.742319644253589 0.455316168872934 0.285536948430425 NA NA NA 0.154757468690133 97.72764725174 a3376 ARID1A_mut 295 NVP-BHG712 EPHB4 5 44 2.32630161961136 NA 3.32684827770003 3.95032870396752 -0.623480426267486 0.747429980762025 1.25813949293293 0.509793440011408 0.834165664095828 0.495557471782442 0.285561423321948 NA NA NA 0.149245757797118 97.72764725174 a3377 loss_cnaBRCA28_(GPS2) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 42 1.38629436111989 NA 3.61928467930786 2.78616396441293 0.833120714894924 0.608219931126568 1.51770677510821 0.565350267138237 1.36976884883037 0.548933910396177 0.285841049685739 NA NA NA 0.064377071698768 97.72764725174 a3378 loss_cnaBRCA23 201 Epothilone B Microtubules 3 45 -3.44201937618241 NA -3.15183827918123 -4.30801923447919 1.15618095529796 1.17372368344379 1.81883917145439 0.643890764089532 0.985053783617657 0.635669702656253 0.285843897873753 NA NA NA 0.221626777044681 97.72764725174 a3379 gain_cnaBRCA9_(KRAS) 1050 ZM-447439 AURKB 3 36 1.38629436111989 0.693147180559945 3.67402085867372 2.82241601679952 0.851604841874193 0.504836298100909 1.34033896366924 0.650634532727158 1.68689304845503 0.635365280692044 0.285937981583981 NA NA NA 0.0687445278331381 97.72764725174 a3380 loss_cnaBRCA28_(GPS2) 158 PF-562271 FAK 4 41 0.940007258491471 NA 2.99430952041291 2.26875661386015 0.725552906552759 1.17875913696463 1.2894808593513 0.565924586314344 0.615522615095989 0.56267055171161 0.285998013209 NA NA NA 0.312975027717801 97.72764725174 a3381 gain_cnaBRCA27_(CLTC,PPM1D) 166 FTI-277 Farnesyl transferase (FNTA) 9 38 0.0237165266173161 NA 1.98194800534165 2.30654473710461 -0.32459673176296 1.18033963169666 0.70609297324302 0.400275323605954 0.275002823802818 0.459708202833568 0.286007169396005 NA NA NA 0.447819691477954 97.72764725174 a3382 gain_cnaBRCA30_(CRNKL1,FOXA2) 152 CP466722 ATM 5 44 2.77258872223978 NA 2.24709780286399 2.78503311951965 -0.537935316655658 0.198686834005753 1.102581720377 0.509306269060515 2.70745326104539 0.48788702616231 0.28601647084715 NA NA NA 0.00696276591964214 97.72764725174 a3383 TP53_mut 224 AS605240 PI3Kgamma 38 11 2.99573227355399 2.32630161961136 3.40072804603486 2.81953772432223 0.581190321712625 1.11985285165019 2.64387376502175 0.369466474584958 0.518988116033457 0.219825291737347 0.286046265655253 NA NA NA 0.491897460027106 97.72764725174 a3384 loss_cnaBRCA20 344 THZ-2-49 CDK9 3 46 2.99573227355399 NA 0.899975179280224 1.84301193990319 -0.943036760622971 1.00876388381432 1.48379976170443 0.642954919721975 0.934843897322315 0.635555271649129 0.286093515703747 NA NA NA 0.240146237196046 97.72764725174 a3385 gain_cnaBRCA19 1007 Docetaxel Microtubules 4 41 -4.38202663467388 NA -5.37846433926097 -4.51009090589459 -0.868373433366385 0.948638427671415 1.57044863525398 0.56561950538578 0.915389265326249 0.552946090609289 0.286254396212206 NA NA NA 0.16734204918539 97.72764725174 a3386 gain_cnaBRCA13_(FGFR1,WHSC1L1) 290 KIN001-260 IKK 11 38 2.99573227355399 NA 5.3410199224788 4.9581154991658 0.382904423312999 1.11897377569223 1.01358065343021 0.369277259482106 0.342192490682924 0.377774005469771 0.28629010831683 NA NA NA 0.32371076096051 97.72764725174 a3387 gain_cnaBRCA14_(RAD21) 1006 Cytarabine DNA synthesis 20 25 0.693147180559945 NA 1.48203544053198 0.989731542203575 0.492303898328402 1.60720782618859 1.44792217441213 0.323806727346961 0.306310042986708 0.34000715440958 0.286446472517813 NA NA NA 0.292723852021286 97.72764725174 a3388 gain_cnaBRCA27_(CLTC,PPM1D) 106 XMD8-85 MAP2K5 (ERK5) 3 10 2.07944154167984 NA 3.90096511328201 3.02098248141401 0.879982631867998 1.24292197841375 1.18207257498099 0.737394869058704 0.707995068999471 0.74444044341537 0.286497451843682 NA NA NA 0.352251577769685 97.72764725174 a3389 gain_cnaBRCA12_(TERT) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 9 33 -1.38629436111989 0.693147180559945 -0.840427096299496 -0.155459006771394 -0.684968089528102 1.0678484490604 1.80803535817441 0.406221162585606 0.641446911432803 0.378846622899963 0.286510266567633 NA NA NA 0.163477211284129 97.72764725174 a3390 loss_cnaBRCA24 276 CAY10603 HDAC6 3 46 2.99573227355399 NA 0.580481250383992 1.21434790811087 -0.633866657726876 0.200666138706792 1.00784091096985 0.642194143850927 3.15881225308802 0.628935232562552 0.28665712876543 NA NA NA 0.00534725069384883 97.72764725174 a3391 gain_cnaBRCA12_(TERT) 1069 EHT 1864 Rac GTPases 10 36 2.30258509299405 NA 3.81908468709405 3.48984863874842 0.329236048345634 0.636654514758328 0.9018918129547 0.38535802351096 0.51713455369214 0.36505049011036 0.286888715867549 NA NA NA 0.204760859239207 97.72764725174 a3392 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 238 CAL-101 PI3Kdelta 6 43 2.99573227355399 2.32630161961136 4.33142919892101 4.77303887345681 -0.441609674535803 0.892832240613726 0.946514092908687 0.469323787476104 0.49461663059148 0.46656428873522 0.287011742889452 NA NA NA 0.29885569936085 97.72764725174 a3393 PIK3CA_mut 167 OSU-03012 PDPK1 (PDK1) 17 31 2.77258872223978 NA 2.00061258034859 2.38363159542325 -0.383019015074652 1.52872240084235 0.939356761543154 0.325066730826265 0.250548441537588 0.407746056402934 0.287050720377168 NA NA NA 0.356939426037282 97.72764725174 a3394 loss_cnaBRCA33 185 OSI-906 IGF1R 6 42 0.940007258491471 NA 2.43183128086325 2.95944114570145 -0.527609864838203 1.00886097256387 1.13546554374473 0.470074545902507 0.522975790705194 0.464663914942027 0.287062586244335 NA NA NA 0.277279414394878 97.72764725174 a3395 loss_cnaBRCA7_(FAS,PTEN) 283 GSK2126458 PI3K, MTOR 4 44 -2.05572501506252 0.0237165266173161 -2.21707811819905 -3.13156515726236 0.914487039063302 2.15421964254074 1.58266638172834 0.562388554269065 0.424509655842118 0.577814155668515 0.287143915472318 NA NA NA 0.462839117811803 97.72764725174 a3396 loss_cnaBRCA36_(FAT1,IRF2) 6 PHA-665752 MET 3 11 0.693147180559945 NA 3.28932552403176 2.74850218366613 0.540823340365638 0.227371123254724 0.810228572530981 0.725512736594078 2.37859290407672 0.667494777030909 0.287144739444653 NA NA NA 0.0754842192429007 97.72764725174 a3397 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 5 38 1.6094379124341 NA 3.62433800306364 2.85663930720849 0.767698695855155 1.35847749241706 1.51132122414535 0.512791647908632 0.565116978485404 0.507965271439424 0.28737407009176 NA NA NA 0.290418745868124 97.72764725174 a3398 NF1_mut 290 KIN001-260 IKK 5 44 2.99573227355399 NA 5.51695658665222 4.9903369359615 0.526619650690717 0.342436523526999 1.07907518194081 0.507849799228582 1.53786063842339 0.488028692999451 0.28737991788017 NA NA NA 0.0313168613404159 97.72764725174 a3399 gain_cnaBRCA10_(MDM2,NUP107) 1005 Cisplatin DNA crosslinker 3 42 1.79175946922805 2.30258509299405 4.37684558431323 3.6196005492485 0.757245035064723 0.820066043784231 1.19113621431813 0.643655736025946 0.923395183600558 0.635733366144202 0.287467051722994 NA NA NA 0.244381551000383 97.72764725174 a3400 gain_cnaBRCA16 1058 GDC0941 PI3K (class 1) 14 29 1.38629436111989 0.693147180559945 1.67216312346934 1.18854575040977 0.483617373059571 1.12727560699835 1.48132588688363 0.3507158720005 0.429014315627145 0.326476015400628 0.287482765876093 NA NA NA 0.24429717932528 97.72764725174 a3401 gain_cnaBRCA64_(SDHC) 1143 HG-5-88-01 EGFR, ADCK4 6 20 2.30258509299405 NA 4.91146231392711 4.42086146737484 0.490600846552276 1.0944548116659 0.933166412984147 0.506304064348919 0.448260486703438 0.525737788808105 0.287523929551312 NA NA NA 0.351513809012707 97.72764725174 a3402 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 5 38 -1.38629436111989 0.693147180559945 -1.79143477126826 -2.2769685684708 0.485533797202541 0.684411294429667 0.971393732102173 0.512582389424484 0.70941815419213 0.499832128988322 0.287568095552966 NA NA NA 0.205465380016691 97.72764725174 a3403 TP53_mut 231 FMK RSK 38 11 2.99573227355399 2.32630161961136 5.63805385388621 5.42056442939376 0.217489424492449 0.574742208921094 0.645857383409939 0.368257455312841 0.378412131763769 0.336745278569346 0.287606831523597 NA NA NA 0.329848061156065 97.72764725174 a3404 ARID1A_mut 1241 CHIR-99021 GSK3B 5 41 2.30258509299405 NA 4.67331065448797 4.1776061702917 0.495704484196273 0.958814962810882 0.974083067449806 0.50961442985947 0.516997025936115 0.508893441186746 0.287871463687228 NA NA NA 0.325055559783836 97.72764725174 a3405 gain_cnaBRCA48 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 38 -1.38629436111989 0.693147180559945 -1.16607452037296 -0.211307710754201 -0.954766809618755 0.974786017679672 1.73125677111999 0.566178999387843 0.979462971669854 0.551487696998922 0.287894527458965 NA NA NA 0.147328204944951 97.72764725174 a3406 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1039 SL 0101-1 RSK, AURKB, PIM3 8 35 2.30258509299405 NA 4.31957555100286 4.7240861438765 -0.40451059287364 1.08164797552012 0.931789643042494 0.421789472460145 0.373976193760384 0.434122224789735 0.288077928821538 NA NA NA 0.352243811377859 97.72764725174 a3407 gain_cnaBRCA62 1053 MK-2206 AKT1, AKT2 7 35 1.38629436111989 0.693147180559945 2.00142635713209 1.27236959198741 0.729056765144678 0.969007333425296 1.7267170414247 0.445744544096072 0.752374868585949 0.422221329641328 0.288120486512996 NA NA NA 0.140411117196409 97.72764725174 a3408 PTEN_mut 1170 CCT018159 HSP90 7 36 2.30258509299405 NA 2.90186697818607 3.42857091093707 -0.526703932751001 0.896296531628844 1.22742803382985 0.444564141010185 0.58764472935516 0.429111865000806 0.288121777586034 NA NA NA 0.210324355099136 97.72764725174 a3409 loss_cnaBRCA28_(GPS2) 221 TAK-715 p38a 4 45 2.99573227355399 2.32630161961136 3.9665653615481 4.52798270077095 -0.561417339222853 0.806976933859941 1.01381767529776 0.560357289980979 0.695704320243052 0.553765586162193 0.288306974758133 NA NA NA 0.264253156328636 97.72764725174 a3410 loss_cnaBRCA20 329 QL-XI-92 DDR1 3 45 2.32630161961136 NA 3.68766584763264 4.29104638156332 -0.603380533930681 0.577599042148772 0.955371747913322 0.640461964736792 1.04463562073441 0.63156623089238 0.28838560837516 NA NA NA 0.201436473277419 97.72764725174 a3411 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 260 NG-25 MAP3K7 (TAK1) 9 40 2.32630161961136 NA 2.79467255710644 3.30141934537832 -0.506746788271884 0.898351435171594 1.34401312438186 0.396153335405508 0.564085243738816 0.377040059415302 0.288402083245367 NA NA NA 0.185251756614345 97.72764725174 a3412 gain_cnaBRCA10_(MDM2,NUP107) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 5 44 1.63315443905142 NA 3.1238321455904 3.62811425644392 -0.504282110853522 1.34892526034526 0.955734148284438 0.506682185480896 0.373839919584907 0.527638477456014 0.288476222214286 NA NA NA 0.457297880578753 97.72764725174 a3413 BRCA2_mut 1023 GW 441756 NTRK1 5 40 0.693147180559945 NA 2.94609852965139 2.28593532355013 0.660163206101256 0.82014768065392 1.33413679771456 0.509794752774748 0.804932113658963 0.494824224346521 0.288484251988602 NA NA NA 0.162636690815913 97.72764725174 a3414 PIK3CA_mut 263 FR-180204 ERK 17 32 2.99573227355399 NA 5.51141601519146 5.27632147877693 0.23509453641453 0.703533513450217 0.742834277280771 0.322182816014648 0.334162526617384 0.316483155940407 0.288525749489833 NA NA NA 0.2824858566474 97.72764725174 a3415 gain_cnaBRCA16 136 Mitomycin C DNA crosslinker 16 32 2.77258872223978 NA 0.188214066297355 -0.29556496172395 0.483779028021305 1.38389640701799 1.51206671214493 0.328766079987556 0.349577486846539 0.319945558046869 0.288537204097546 NA NA NA 0.276588470542193 97.72764725174 a3416 POLR2B_mut 345 KIN001-270 CDK9 3 46 2.99573227355399 NA 4.69503581187552 5.13449249967456 -0.439456687799038 0.507466437723875 0.693962880262549 0.639620120556152 0.865981777573549 0.633256763867222 0.288569804243013 NA NA NA 0.26791025577829 97.72764725174 a3417 PIK3CA_mut 230 GSK429286A ROCK2 17 32 2.99573227355399 2.32630161961136 5.59324520738936 5.30576584966061 0.287479357728759 1.01477166533819 0.822840206812877 0.321989262405397 0.283294624345813 0.34937446584223 0.288812034284021 NA NA NA 0.323422897615345 97.72764725174 a3418 loss_cnaBRCA20 310 YM201636 FYV1 3 46 1.63315443905142 NA 3.02212044186553 2.37505098653426 0.647069455331273 0.618833418165631 1.02622897029259 0.639245933967133 1.0456278480392 0.63053126939769 0.288848588021344 NA NA NA 0.201189842640008 97.72764725174 a3419 gain_cnaBRCA62 163 JQ1 BRD4 9 38 0.940007258491471 NA 0.782630425404178 0.205379293863804 0.577251131540374 1.67568455926366 1.39780095722788 0.3978032796033 0.344486752204742 0.412970908737378 0.288955731769416 NA NA NA 0.35924545187422 97.72764725174 a3420 gain_cnaBRCA47_(EGFR) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 6 39 -0.669430653942629 NA -4.4729209330109 -3.33438696056471 -1.1385339724462 1.55567612034154 2.51013006467888 0.470745277034837 0.731857973236896 0.453575688553751 0.2890501561165 NA NA NA 0.162015733910824 97.72764725174 a3421 loss_cnaBRCA57 163 JQ1 BRD4 5 42 0.940007258491471 NA -0.342135237190031 0.394256266224102 -0.736391503414134 1.64359543873616 1.4309459921258 0.50746752737054 0.448036959740153 0.514618656096279 0.289135014906361 NA NA NA 0.383560500340999 97.72764725174 a3422 BRCA2_mut 292 Masitinib KIT 6 42 2.99573227355399 NA 3.56633880589968 4.07375432074621 -0.507415514846534 0.729171257725397 1.11995269860119 0.467957282325735 0.695879753172642 0.453068701455241 0.289212241939317 NA NA NA 0.175230187298149 97.72764725174 a3423 PIK3CA_mut 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 16 29 2.30258509299405 NA 3.45588338723089 3.02292689048763 0.432956496743264 0.891340560572267 1.46708212898014 0.334166069801434 0.485736334566995 0.295114014540031 0.289239258159557 NA NA NA 0.225411494732483 97.72764725174 a3424 gain_cnaBRCA63 1009 ATRA Retinoic acid and retinoid X receptor agonist 6 39 2.30258509299405 NA 4.57537466955319 4.03375490266776 0.541619766885431 0.800144509329069 1.18998230111071 0.470379136210551 0.676902435210842 0.455149430693121 0.289420483819339 NA NA NA 0.186455108730406 97.72764725174 a3425 loss_cnaBRCA17 71 Pyrimethamine Dihydrofolate reductase (DHFR) 4 10 2.99573227355399 NA 4.10839269761941 4.75402190056411 -0.645629202944693 1.02166851449915 0.972074103324984 0.655656216959383 0.631936086687763 0.664176939531991 0.289467701972413 NA NA NA 0.325358471943533 97.72764725174 a3426 gain_cnaBRCA19 275 I-BET BRD2, BRD3, BRD4 4 45 2.99573227355399 NA 3.34443049224341 4.10067533196186 -0.756244839718455 0.588288799704674 1.38985375082866 0.558958311226818 1.28549929915051 0.54411828529985 0.289497911921114 NA NA NA 0.0760317127435233 97.72764725174 a3427 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 238 CAL-101 PI3Kdelta 9 40 2.99573227355399 2.32630161961136 5.0225171476674 4.65066481057906 0.371852337088336 0.67730723358031 0.986499441989526 0.39513673297882 0.54901574743664 0.376941254359356 0.289626306593142 NA NA NA 0.193456178090036 97.72764725174 a3428 gain_cnaBRCA9_(KRAS) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 4 45 3.68887945411394 NA 2.84902296273333 3.5137195638736 -0.664696601140269 0.46325433800492 1.22357125385482 0.558733619698982 1.43484161206756 0.543243067411207 0.289689507944129 NA NA NA 0.055553069554439 97.72764725174 a3429 gain_cnaBRCA63 1031 Elesclomol HSP70 6 38 -1.6094379124341 NA -2.25512360893342 -3.09165098556611 0.836527376632695 2.12902465912087 1.72270385289144 0.471029125265891 0.392915776268236 0.485589775183147 0.289738313790264 NA NA NA 0.394434517845747 97.72764725174 a3430 BRCA1_mut 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 4 43 2.77258872223978 NA 5.53325043344809 4.96231088286725 0.570939550580836 0.616816417298103 1.04264479129512 0.559852707591969 0.925623142590424 0.54758778382391 0.289880615973292 NA NA NA 0.163448490812052 97.72764725174 a3431 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 299 OSI-027 MTORC1/2 7 41 2.99573227355399 NA 0.530133520955006 1.39511230262381 -0.864978781668804 1.58420627974973 2.0276852346789 0.437854381259439 0.54600135899313 0.426584346956484 0.289909721854759 NA NA NA 0.231289896183133 97.72764725174 a3432 loss_cnaBRCA17 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 4 10 1.38629436111989 NA 2.28927718915526 1.77310625578545 0.516170933369813 0.558668855786055 0.851001047875036 0.654914911828599 0.923930031223153 0.606545590817662 0.289987788898548 NA NA NA 0.217220915793855 97.72764725174 a3433 PIK3CA_mut 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 16 29 -0.669430653942629 NA -2.96617310019533 -3.77309818817116 0.806925087975826 2.9286322384279 2.09508478101538 0.33361851913571 0.275529674701999 0.38515152001856 0.290019853065154 NA NA NA 0.340276736064886 97.72764725174 a3434 loss_cnaBRCA38 151 QS11 ARFGAP 4 44 2.32630161961136 NA 4.51559844882847 3.69180002402169 0.823798424806779 0.868868913539827 1.50696316858018 0.558964513656187 0.948127401002956 0.546661286740629 0.290052428565741 NA NA NA 0.155653532194032 97.72764725174 a3435 ARID1A_mut 177 GSK-650394 SGK3 5 42 2.77258872223978 NA 3.25104252241567 4.10531932180712 -0.854276799391445 2.27944375827443 1.61847961386817 0.50616414436518 0.374774238798567 0.527826728289597 0.290359914537371 NA NA NA 0.456622487495524 97.72764725174 a3436 gain_cnaBRCA16 1494 SN-38 TOP1 17 31 -2.99573227355399 NA -2.9544888062537 -3.49533996032321 0.54085115406951 2.13455703102057 1.36926877586694 0.322784309483312 0.253378638382372 0.394992687777514 0.290406649444193 NA NA NA 0.354991468295709 97.72764725174 a3437 BRCA1_mut 164 JQ12 HDAC 4 43 1.63315443905142 NA 2.413654697556 1.50013698281936 0.913517714736636 1.31779162103271 1.65377089070391 0.559231424334234 0.693218639545408 0.552384686338145 0.290409532856419 NA NA NA 0.266088992787454 97.72764725174 a3438 loss_cnaBRCA29_(MAP2K4) 184 BMS-754807 IGF1R 7 41 0.940007258491471 NA 2.25104001785228 1.52030316340654 0.730736854445743 1.37698926298945 1.71039744963858 0.437387044870187 0.530677234809593 0.427232193663615 0.290418564783792 NA NA NA 0.241585508189525 97.72764725174 a3439 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 310 YM201636 FYV1 6 43 1.63315443905142 NA 2.00077547583712 2.47241985700348 -0.471644381166368 0.745138648442405 1.03956550873854 0.465903495236813 0.632961908702852 0.453693756864525 0.290496368782419 NA NA NA 0.206363866117189 97.72764725174 a3440 gain_cnaBRCA10_(MDM2,NUP107) 1219 PFI-1 BRD2, BRD3, BRD4 3 44 2.30258509299405 NA 2.57910599043178 3.21293845371006 -0.633832463278282 0.872553538192869 0.998370915362713 0.638225006920287 0.726410971401253 0.634866714890235 0.290513752413137 NA NA NA 0.334426395518211 97.72764725174 a3441 ASH1L_mut 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 46 3.68887945411394 NA 4.17074446469162 3.41307040937327 0.757674055318346 1.07783457371801 1.19443319436813 0.636859104111436 0.702959502129104 0.634337741860199 0.29063127867962 NA NA NA 0.347094545340758 97.72764725174 a3442 ARID1A_mut 1175 AG-014699 PARP1, PARP2 5 38 1.6094379124341 NA 3.40204075423522 3.92203510833163 -0.519994354096405 1.47357574465099 0.959387931320944 0.509291010036301 0.352879284274296 0.542006353342849 0.290631938027056 NA NA NA 0.481200210437373 97.72764725174 a3443 loss_cnaBRCA57 1025 SB 216763 GSK3A, GSK3B 3 36 2.30258509299405 NA 5.35411317112023 4.85041534675474 0.503697824365489 0.174390886152013 0.803047781260712 0.644037486954846 2.88832653746839 0.627232695387975 0.290776545841723 NA NA NA 0.0100974149241876 97.72764725174 a3444 BRCA2_mut 260 NG-25 MAP3K7 (TAK1) 6 43 2.32630161961136 NA 2.6856085193985 3.2812831561093 -0.595674636710799 0.834026367067096 1.32238169197228 0.465617818443064 0.714215593453628 0.450455901141806 0.29078874302769 NA NA NA 0.166549080417169 97.72764725174 a3445 loss_cnaBRCA24 294 MPS-1-IN-1 MPS1 3 46 2.99573227355399 NA 5.45394064603136 4.71103359797089 0.742907048060462 1.29654228247081 1.16090141857996 0.63659854188859 0.572990991581634 0.639939822770829 0.290826350613227 NA NA NA 0.426783404569633 97.72764725174 a3446 gain_cnaBRCA27_(CLTC,PPM1D) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 9 39 2.77258872223978 NA -0.886320957180114 -0.332728642544218 -0.553592314635896 1.74978523916715 1.3161911484358 0.395064736395808 0.316377291478005 0.420601760841349 0.290950809316898 NA NA NA 0.392642876606222 97.72764725174 a3447 gain_cnaBRCA48 230 GSK429286A ROCK2 5 44 2.99573227355399 2.32630161961136 5.80956407786627 5.35958762103244 0.449976456833837 0.314343700652609 0.928595032898022 0.503936301849299 1.43147916086641 0.484577712449656 0.291065864736089 NA NA NA 0.0390357775326963 97.72764725174 a3448 loss_cnaBRCA36_(FAT1,IRF2) 277 ABT-869 VEGFR and PDGFR family 9 39 0.0237165266173161 NA 2.53925155273574 2.7261151775837 -0.186863624847962 0.254680405196886 0.507365970269574 0.394881534976852 0.733718107223456 0.368301454566765 0.291171878051473 NA NA NA 0.124365036555389 97.72764725174 a3449 gain_cnaBRCA9_(KRAS) 1032 Afatinib ERBB2, EGFR 4 41 -0.693147180559945 NA -0.639103234261534 0.381161935727498 -1.02026516998903 2.09136584638863 1.80086316766454 0.559775147145585 0.487846338196076 0.566542304994871 0.291196904016196 NA NA NA 0.407291373979499 97.72764725174 a3450 PTEN_mut 293 MP470 PDGFR 9 39 2.99573227355399 NA 2.99843500255963 3.65461983075872 -0.656184828199093 1.44696681768447 1.70359781855271 0.394860186969767 0.453489893603202 0.385175903052372 0.291197646229885 NA NA NA 0.25656004984727 97.72764725174 a3451 loss_cnaBRCA60 154 CHIR-99021 GSK3B 3 44 0.940007258491471 NA 3.81331632696967 3.23876325918488 0.574553067784782 0.349416102138755 0.919307462514746 0.637216757339291 1.64432338483538 0.624984666406497 0.291267044361132 NA NA NA 0.0743468233722155 97.72764725174 a3452 MLL3_mut 135 Gemcitabine DNA replication 3 44 0.0237165266173161 NA -1.91523138455718 -0.1634050259968 -1.75182635856038 3.16834376584363 2.72919976536426 0.636979895843299 0.552915494033811 0.641882789524044 0.291444207051594 NA NA NA 0.440705715727839 97.7300682675861 a3453 gain_cnaBRCA19 286 KIN001-236 TIE2 4 45 2.32630161961136 NA 4.15002155394219 4.57477798535052 -0.424756431408338 0.71868372248166 0.766507072871123 0.556295932468959 0.591019969036765 0.554145482072746 0.291773805488774 NA NA NA 0.328797955393199 97.7300682675861 a3454 gain_cnaBRCA9_(KRAS) 1054 PD-0332991 CDK4, CDK6 4 38 1.38629436111989 0.693147180559945 3.62349033909755 2.80494835928606 0.818541979811496 0.848949314413237 1.49622303703941 0.561536868668804 0.964182391003216 0.547072167416398 0.291809725724642 NA NA NA 0.152326850146006 97.7300682675861 a3455 loss_cnaBRCA60 1259 BMN-673 PARP1 3 43 2.30258509299405 NA 4.22830370447067 3.24115904068445 0.987144663786213 1.77505868228063 1.53782723734164 0.637114691164454 0.556119453199098 0.641908687670687 0.291825372143718 NA NA NA 0.438507894134886 97.7300682675861 a3456 loss_cnaBRCA7_(FAS,PTEN) 1149 TW 37 BCL2, BCL2L1 4 39 1.6094379124341 NA 0.488186130845901 -0.207058126733952 0.695244257579853 1.11048748700599 1.25021532058917 0.560443518154101 0.626071221616656 0.556099614306612 0.292000319240224 NA NA NA 0.306871562244836 97.7300682675861 a3457 gain_cnaBRCA8_(CHD4,WNK1) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 40 1.6094379124341 NA 3.51540687326907 2.49623648701524 1.01917038625383 1.14232444740438 1.61482044640566 0.638969283749699 0.892189945308107 0.631135423459828 0.292026127333919 NA NA NA 0.256794000296938 97.7300682675861 a3458 gain_cnaBRCA31 219 AT-7519 CDK9 16 33 2.32630161961136 NA 2.06633002794152 1.48081043084497 0.585519597096545 1.50927910732248 1.92653298939113 0.324588372215042 0.387946533053968 0.303923992125147 0.292094660708604 NA NA NA 0.253497959760716 97.7300682675861 a3459 ASH1L_mut 266 Zibotentan, ZD4054 Endothelin A Receptor 3 46 2.99573227355399 NA 5.44990255943164 5.76109178613808 -0.311189226706443 0.396810817074944 0.493970267341291 0.63478435789508 0.784225664512744 0.629975622584259 0.292187073196664 NA NA NA 0.305054884712248 97.7300682675861 a3460 gain_cnaBRCA27_(CLTC,PPM1D) 1133 JNJ-26854165 MDM2 9 34 2.30258509299405 NA 3.24325925556572 2.89616897871637 0.347090276849348 0.896680063438725 0.8606488359225 0.39996722255951 0.387083744806675 0.403289079543475 0.292229448527391 NA NA NA 0.317968159847289 97.7300682675861 a3461 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 3 23 2.30258509299405 NA 1.97792329935571 2.78462338349736 -0.806700084141646 1.23350976216722 1.21932721865818 0.660950357138887 0.653987596112987 0.661594420101101 0.292305741018119 NA NA NA 0.376885116570191 97.7300682675861 a3462 gain_cnaBRCA15 190 Bleomycin DNA damage 22 26 4.15888308335967 NA 2.53479402262142 1.69221888485158 0.84257513776984 2.66309076269028 2.78654977043943 0.308536066126035 0.316389944186004 0.302372183231082 0.29239734954257 NA NA NA 0.290647050160112 97.7300682675861 a3463 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 211 TL-2-105 CRAF 7 42 2.32630161961136 1.63315443905142 3.50411019544112 3.97479432669944 -0.470684131258317 0.846579107574675 1.11385958685714 0.434444324304781 0.555983637024493 0.422570435997589 0.292689990680308 NA NA NA 0.224581545690523 97.7300682675861 a3464 BRCA1_mut 286 KIN001-236 TIE2 4 45 2.32630161961136 NA 4.92937970935797 4.50550170486912 0.423878004488846 0.513980532922952 0.777688670946971 0.555117734008056 0.824696612687445 0.545048449751365 0.292784921468814 NA NA NA 0.201770781354977 97.7300682675861 a3465 gain_cnaBRCA16 258 STF-62247 stimulates autophagy 16 33 2.32630161961136 NA 4.83972159751696 4.5295683879834 0.310153209533566 0.874300114193857 0.993405712793445 0.324087289663275 0.354744560246959 0.31221202529772 0.292831481420616 NA NA NA 0.273709717250892 97.7300682675861 a3466 ASH1L_mut 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 3 45 2.32630161961136 NA 4.54652034086729 4.98595507431784 -0.43943473345055 0.16674670334327 0.707339563608981 0.634411698842078 2.63534285619978 0.621250041788232 0.292908859795074 NA NA NA 0.0130496471789843 97.7300682675861 a3467 gain_cnaBRCA14_(RAD21) 1373 Dabrafenib BRAF 20 26 2.30258509299405 NA 4.50569799782686 3.99065923438742 0.51503876343944 1.02910674615456 1.96355546466602 0.316506743451824 0.500471661821257 0.262299065500063 0.293062900008864 NA NA NA 0.257846440696444 97.7300682675861 a3468 gain_cnaBRCA15 152 CP466722 ATM 22 27 2.77258872223978 NA 2.55233754778682 2.87501926747684 -0.322681719690021 0.834017568708218 1.20674597549216 0.305400782571851 0.386900386510817 0.26739821490469 0.293068267319399 NA NA NA 0.275686801080776 97.7300682675861 a3469 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 89 Parthenolide NFKB1 4 10 1.6094379124341 NA 3.89145931194933 2.99322817085082 0.898231141098513 1.47403298567375 1.34824582483544 0.650530413731018 0.609369769759902 0.666222082466411 0.2930783980181 NA NA NA 0.338395018124731 97.7300682675861 a3470 gain_cnaBRCA14_(RAD21) 1527 GDC0941 (rescreen) PI3K 19 26 1.38629436111989 NA 1.19419527737697 0.824607791969242 0.369587485407725 1.31297561953471 1.01747299148448 0.32125596095204 0.281488460188391 0.363240585746166 0.293084418963682 NA NA NA 0.313860496148374 97.7300682675861 a3471 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 106 XMD8-85 MAP2K5 (ERK5) 3 10 2.07944154167984 NA 3.89211691460842 3.02363694101609 0.868479973592335 1.22560862685307 1.18825499800869 0.726680359070795 0.708611178612771 0.73088686775798 0.293196738633866 NA NA NA 0.352575233343211 97.7300682675861 a3472 loss_cnaBRCA18 326 GSK690693 AKT 15 33 2.32630161961136 NA 2.50239853392422 3.13829630350263 -0.635897769578406 1.47346974339593 2.08676398437746 0.33103294379971 0.431564864109692 0.304729128132864 0.293308832691649 NA NA NA 0.234271076658116 97.7300682675861 a3473 gain_cnaBRCA64_(SDHC) 230 GSK429286A ROCK2 8 41 2.99573227355399 2.32630161961136 5.71243008360385 5.34561548892507 0.366814594678782 1.27082295884704 0.808967460742238 0.410755839289091 0.288643348882819 0.453435536631134 0.293334844150926 NA NA NA 0.454173295624882 97.7300682675861 a3474 loss_cnaBRCA36_(FAT1,IRF2) 197 Bryostatin 1 PRKC 9 39 -4.8283137373023 NA -3.1139884548779 -2.7359151849858 -0.378073269892099 0.676389576973999 1.01192286604247 0.393002301525161 0.558957859143108 0.373618664603072 0.293446280683573 NA NA NA 0.190648589432729 97.7300682675861 a3475 gain_cnaBRCA48 157 JNK-9L JNK 5 42 1.63315443905142 NA -0.416376580035125 0.11206106899996 -0.528437649035085 0.790491250084162 1.07284961742763 0.502877461581111 0.668492723959719 0.492555191753827 0.293464698432045 NA NA NA 0.225230199409766 97.7300682675861 a3476 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 153 Midostaurin KIT 6 41 -0.669430653942629 NA 0.0249869104437209 0.69811535539482 -0.673128444951099 1.25975771104569 1.47067968692003 0.46462348342779 0.534331672708994 0.457698879598179 0.293468111438273 NA NA NA 0.270147084207102 97.7300682675861 a3477 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 196 Phenformin AAPK1 (AMPK) agonist 6 42 8.29404964010203 NA 7.93383934478605 7.09746647537393 0.836372869412118 1.21885674877639 1.86208439744653 0.463797000092631 0.686194559165177 0.449159485230119 0.293468734231278 NA NA NA 0.180344441972883 97.7300682675861 a3478 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 306 TG101348 JAK2 14 34 2.32630161961136 NA 3.53003077514958 3.09924229021905 0.430788484930531 1.05939263904682 1.3535618939966 0.337261403307446 0.406637226890804 0.318262863960038 0.293752168461446 NA NA NA 0.248352439235039 97.7548658867869 a3479 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1378 Bleomycin (50 uM) DNA damage 6 42 3.91202300542815 NA 4.57401049288535 3.70396148749711 0.870049005388234 1.01844716296613 1.95656847437365 0.463421900414242 0.854289782549252 0.444681091811397 0.293854631360693 NA NA NA 0.117807945186551 97.7548658867869 a3480 loss_cnaBRCA33 1043 JNK Inhibitor VIII JNK 5 38 2.30258509299405 NA 4.46557572595898 4.84098321475771 -0.375407488798727 0.825898555684648 0.732535702007625 0.505829928376079 0.454544309606552 0.512476713107451 0.293878235307329 NA NA NA 0.378868898485809 97.7548658867869 a3481 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1061 SB590885 BRAF 5 37 1.6094379124341 NA 4.49506565375849 3.94662062109809 0.548445032660394 1.1445262706322 1.07505507048357 0.506785775563718 0.479189553558653 0.510155291313308 0.293880894854396 NA NA NA 0.357595703265943 97.7548658867869 a3482 gain_cnaBRCA15 1020 Lenalidomide TNFA 21 24 1.6094379124341 NA 4.37437346919383 4.15003554611317 0.224337923080662 0.736073488204982 0.680411331016339 0.317378713223083 0.304776529348641 0.329709269752409 0.294095675232611 NA NA NA 0.296918273896705 97.7852443139849 a3483 gain_cnaBRCA14_(RAD21) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 21 26 2.32630161961136 NA 1.15410619842755 1.6292221080256 -0.475115909598054 1.5835429086401 1.47760710600086 0.311429272299675 0.30003349262324 0.321544142328846 0.294141122675196 NA NA NA 0.298189189203364 97.7852443139849 a3484 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1066 AZD6482 PI3Kbeta 7 36 1.6094379124341 NA 2.49287489297564 1.86497067173029 0.627904221245345 1.32514882545578 1.44851808570015 0.438747621459511 0.473836756433287 0.433480415221632 0.294389618970046 NA NA NA 0.287878060517602 97.8215659315659 a3485 gain_cnaBRCA16 1072 BMS-708163 g-secretase 16 30 1.6094379124341 NA 3.88786317717468 3.57565595117157 0.312207226003109 1.13614292585271 0.838361519287373 0.328494607100947 0.274795731152211 0.372401665415765 0.294419343010197 NA NA NA 0.342908085124088 97.8215659315659 a3486 gain_cnaBRCA58_(CCND1) 330 XMD13-2 RIPK 10 38 2.32630161961136 NA 4.08235079199545 3.62593452125503 0.456416270740419 1.17706362403059 1.21920450071591 0.376868728957021 0.387758368725664 0.374355795498143 0.294508081169512 NA NA NA 0.296541559080833 97.8229796862243 a3487 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1067 CCT007093 PPM1D 5 41 1.88706964903238 NA 4.52483337765801 4.03207559539995 0.492757782258057 0.645719918175761 1.00842571012811 0.502296591896194 0.763113802730692 0.488640637886413 0.294761555500516 NA NA NA 0.179839472094555 97.8577961258572 a3488 gain_cnaBRCA10_(MDM2,NUP107) 1016 Temsirolimus MTOR 3 41 -1.6094379124341 NA -0.869610357239724 -1.81542856413057 0.945818206890849 0.270407440198591 1.52671464580717 0.634313732197596 3.49775215576993 0.619512106920805 0.294956265730122 NA NA NA 0.00394660951621417 97.8577961258572 a3489 gain_cnaBRCA8_(CHD4,WNK1) 1230 IOX2 EGLN1 3 44 -2.30258509299405 NA -0.135618569289478 0.27571825423647 -0.411336823525949 0.492191170829285 0.657271828356158 0.63202402681892 0.835725725906244 0.625824515489589 0.295168170504585 NA NA NA 0.281052928685868 97.8577961258572 a3490 loss_cnaBRCA29_(MAP2K4) 133 Doxorubicin DNA intercalating 7 41 0.0237165266173161 NA -1.70636660498398 -0.915277877432717 -0.791088727551268 1.65348672241159 1.85153931822064 0.433016678613664 0.478436697935788 0.427260020765597 0.295207129971852 NA NA NA 0.280954129856188 97.8577961258572 a3491 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 185 OSI-906 IGF1R 6 42 0.940007258491471 NA 2.43965265969077 2.95832380586895 -0.518671146178181 1.06981360628191 1.12917149372685 0.461914938600111 0.484823845137657 0.459337796835712 0.295408513898985 NA NA NA 0.308061083972375 97.8577961258572 a3492 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1494 SN-38 TOP1 6 42 -2.99573227355399 NA -2.62646559368186 -3.40054892652955 0.77408333284769 0.721645706453291 1.75728577793372 0.461861504626616 1.07266394842438 0.440499401160513 0.295463715743093 NA NA NA 0.0714595240810464 97.8577961258572 a3493 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 15 34 3.68887945411394 NA 3.18869161599288 3.578914646628 -0.39022303063512 0.843969064430281 1.30944745468825 0.327921444805877 0.462366509723362 0.298005872047782 0.295494673420019 NA NA NA 0.219583958133565 97.8577961258572 a3494 loss_cnaBRCA29_(MAP2K4) 1166 QL-VIII-58 MTOR, ATR 3 23 2.30258509299405 NA -0.87341941058685 -1.60323676866879 0.729817358081939 1.18203095964608 1.10550449281538 0.656261678195437 0.617426601330696 0.660166795182638 0.295663706666699 NA NA NA 0.399446161389303 97.8577961258572 a3495 gain_cnaBRCA9_(KRAS) 1001 AICAR AAPK1 (AMPK) agonist 4 41 7.60090245954208 NA 8.43267195917736 7.67075757243361 0.761914386743743 1.42380961788003 1.37038032410134 0.554452079292852 0.535123781421136 0.555987541081622 0.295749978018026 NA NA NA 0.369843485175496 97.8577961258572 a3496 gain_cnaBRCA64_(SDHC) 228 KIN001-102 AKT1 8 41 2.32630161961136 NA 1.46487283260294 2.03713398883419 -0.572261156231258 1.19651264346221 1.43337950008698 0.408570471187742 0.478274224144739 0.39923911022624 0.295880458669665 NA NA NA 0.256282582900222 97.8577961258572 a3497 BRCA2_mut 184 BMS-754807 IGF1R 6 42 0.940007258491471 NA 0.95210631976137 1.72326361681109 -0.771157297049722 1.99643790158965 1.62703379186148 0.461454017780599 0.386266608360668 0.473965138835529 0.295884919018948 NA NA NA 0.400791368291694 97.8577961258572 a3498 gain_cnaBRCA63 106 XMD8-85 MAP2K5 (ERK5) 3 10 2.07944154167984 NA 3.88826920602918 3.02479125358986 0.863477952439323 1.66296047226441 1.06462824072547 0.72203580908931 0.519241417244 0.811060536822624 0.296137774550342 NA NA NA 0.469187508963778 97.8577961258572 a3499 ASH1L_mut 1091 BMS-536924 IGF1R 3 44 1.38629436111989 NA 2.37997126749714 3.06716569317384 -0.687194425676702 0.895565223672881 1.09770450328148 0.630732982111312 0.767330404879266 0.626028611181246 0.296143679919101 NA NA NA 0.31336912299159 97.8577961258572 a3500 BRCA1_mut 1248 FK866 NAMPT 4 40 0 NA 0.711299783044418 -0.786906435707162 1.49820621875158 0.868102485485031 2.79230107128287 0.554744751261378 1.72584025941879 0.536548953893162 0.296167325601588 NA NA NA 0.0331751633398295 97.8577961258572 a3501 loss_cnaBRCA17 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 9 34 1.6094379124341 NA 3.41561073763011 2.82157314854617 0.594037589083942 1.38432098339308 1.52410374234264 0.396592517735568 0.429118388155836 0.389761912250716 0.296265416534618 NA NA NA 0.282024519926739 97.8577961258572 a3502 loss_cnaBRCA23 271 VNLG/124 HDAC, RAR 3 46 1.63315443905142 NA 3.67305011889389 4.18263945259178 -0.509589333697892 1.28093967232129 0.782176587840322 0.62936838923751 0.397824616341552 0.651501645050418 0.296275533411765 NA NA NA 0.563341926284771 97.8577961258572 a3503 POLR2B_mut 1529 MLN4924 NEDD8-activating enzyme 3 34 0 NA 1.36027561283322 0.281768771718834 1.07850684111439 2.5185456183127 1.62561657712368 0.638395173706643 0.428226049698052 0.663444785376552 0.296423765962179 NA NA NA 0.537462596261753 97.8577961258572 a3504 loss_cnaBRCA29_(MAP2K4) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 6 39 -0.669430653942629 NA -4.458028567809 -3.33667809367269 -1.12135047413631 1.08538125815855 2.54352077012995 0.463454486283845 1.03313970616997 0.440865467781897 0.296486638258421 NA NA NA 0.08142928815944 97.8577961258572 a3505 CDH1_mut 1005 Cisplatin DNA crosslinker 4 41 1.79175946922805 2.30258509299405 4.26372593661975 3.61216722133897 0.651558715280777 1.33132615371542 1.16465829768811 0.553551178741782 0.489405780441127 0.559441955270613 0.296525417498118 NA NA NA 0.406162058494016 97.8577961258572 a3506 gain_cnaBRCA62 268 YM155 BIRC5 (Survivin) 10 39 1.63315443905142 NA -4.06923672380026 -3.4741270476631 -0.595109676137151 1.53897249940991 1.60357976422529 0.373950913083505 0.386692859271583 0.371113236406208 0.296822509129735 NA NA NA 0.297193514619524 97.8577961258572 a3507 PIK3CA_mut 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 16 31 2.32630161961136 NA 1.08997133705122 1.5856923736395 -0.495721036588278 1.95044266438498 1.26096350013949 0.324890502729317 0.254158220408182 0.393128775363791 0.296862955195951 NA NA NA 0.366665364125805 97.8577961258572 a3508 loss_cnaBRCA60 299 OSI-027 MTORC1/2 3 45 2.99573227355399 NA 0.103450605777819 1.34667082748728 -1.24322022170947 1.36022812471186 1.99968557099059 0.629099422163422 0.913979206225293 0.621707852346811 0.296920741985793 NA NA NA 0.248118840799599 97.8577961258572 a3509 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1218 JQ1 BRD2, BRD3, BRD4 14 32 0 NA 2.62233687602071 2.38607655775146 0.236260318269258 0.70280736496362 0.697181145208558 0.338071035424474 0.336166537300712 0.338879385785142 0.297166957838383 NA NA NA 0.303147140164486 97.8577961258572 a3510 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 344 THZ-2-49 CDK9 7 42 2.99573227355399 NA 2.32659110111351 1.69505564441888 0.631535456694624 1.49352498328491 1.46368957861015 0.430338419522491 0.422848940434596 0.431468165056076 0.297221725576804 NA NA NA 0.329153017930734 97.8577961258572 a3511 loss_cnaBRCA7_(FAS,PTEN) 1378 Bleomycin (50 uM) DNA damage 4 44 3.91202300542815 NA 2.86501845118811 3.89887208244178 -1.03385363125367 1.32911323761352 1.91016959500325 0.550577160247423 0.777852181436403 0.54123656556889 0.297263288802779 NA NA NA 0.223031692501754 97.8577961258572 a3512 loss_cnaBRCA36_(FAT1,IRF2) 207 AS601245 JNK 9 39 2.07944154167984 NA 1.86147873551014 2.35959809260596 -0.498119357095828 1.23121287413891 1.28745582409975 0.389809813564286 0.404576144027249 0.386902096189698 0.297338253482232 NA NA NA 0.298776487996961 97.8577961258572 a3513 loss_cnaBRCA18 170 Shikonin unknown 15 32 2.77258872223978 NA -0.261654960151824 0.127950023014993 -0.389604983166817 0.848540205797724 1.30413026655299 0.329790463193625 0.459147345647039 0.298746983456338 0.29754332641708 NA NA NA 0.227732137515182 97.8577961258572 a3514 BRCA2_mut 329 QL-XI-92 DDR1 6 42 2.32630161961136 NA 3.87423269419608 4.30749258447788 -0.433259890281799 0.385647412513976 0.989239812794151 0.45967000914722 1.12346116225037 0.437972556985993 0.297733865398731 NA NA NA 0.0646565724192209 97.8577961258572 a3515 ARID1A_mut 1020 Lenalidomide TNFA 5 40 1.6094379124341 NA 3.94057624091992 4.29399536887967 -0.353419127959751 1.02773129805092 0.665404480715656 0.499895133367761 0.343882811227027 0.53113427727394 0.297827729453971 NA NA NA 0.491384308251443 97.8577961258572 a3516 loss_cnaBRCA29_(MAP2K4) 150 Bicalutamide ANDR (androgen receptor) 7 41 0.0237165266173161 NA 2.53425772674502 2.80157091703694 -0.267313190291928 0.957173617955962 0.552900234354891 0.4306314627053 0.279273462282395 0.483474546911383 0.297843506496052 NA NA NA 0.496618029172684 97.8577961258572 a3517 gain_cnaBRCA16 235 QL-XII-47 BTK, BMX 16 33 2.32630161961136 NA 1.38463865418598 1.86489276300712 -0.480254108821134 1.39422450321208 1.54395060580182 0.320641238740836 0.344459667517463 0.311055358258514 0.2979336305386 NA NA NA 0.283186921869014 97.8577961258572 a3518 CDH1_mut 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 4 39 1.6094379124341 NA 3.69784116555229 2.86878510325722 0.829056062295065 0.671179736087164 1.54453507506222 0.55344301852512 1.23522212861831 0.536767390835501 0.297988601207795 NA NA NA 0.0871662219428243 97.8577961258572 a3519 loss_cnaBRCA57 151 QS11 ARFGAP 5 43 2.32630161961136 NA 4.41737628622078 3.68406310281778 0.733313183403 1.48436163637393 1.47342742779369 0.497370056166432 0.494025960677867 0.497692095023006 0.298006036440498 NA NA NA 0.343656917088394 97.8577961258572 a3520 gain_cnaBRCA9_(KRAS) 1241 CHIR-99021 GSK3B 4 42 2.30258509299405 NA 3.74191912018908 4.27811261365817 -0.536193493469089 0.735841675878314 0.988365063721191 0.550941538867722 0.72868051789684 0.542505510514832 0.298141297491393 NA NA NA 0.247661979398009 97.8577961258572 a3521 PTEN_mut 1259 BMN-673 PARP1 7 39 2.30258509299405 NA 2.73770259555742 3.40745722292158 -0.669754627364159 2.58747796813779 1.31317493546675 0.432123197652282 0.25884457205492 0.510026965391405 0.298219593377255 NA NA NA 0.525988884003196 97.8577961258572 a3522 loss_cnaBRCA20 197 Bryostatin 1 PRKC 3 45 -4.8283137373023 NA -2.24091207974921 -2.84453004597999 0.603617966230783 0.142256908395859 0.983403013365851 0.627302117436266 4.24315397429482 0.613805284330791 0.298286637920882 NA NA NA 0.00146725846748752 97.8577961258572 a3523 gain_cnaBRCA58_(CCND1) 1066 AZD6482 PI3Kbeta 8 35 1.6094379124341 NA 1.48620448346522 2.07712664472567 -0.590922161260448 1.00457253741831 1.50436518780803 0.41281603793246 0.588232446388674 0.392804995787934 0.298317546724846 NA NA NA 0.195908909273662 97.8577961258572 a3524 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 208 SB-715992 KIF11 6 43 -2.05572501506252 NA -0.555922063652522 -1.33533796541557 0.779415901763052 1.28465863515556 1.74378236427376 0.458253333940555 0.606710514710916 0.446968565419378 0.29839644243586 NA NA NA 0.222333762904924 97.8577961258572 a3525 loss_cnaBRCA20 1021 Axitinib PDGFR, KIT, VEGFR 3 42 0.693147180559945 NA 3.14631954137067 2.41349702628374 0.73282251508693 0.353393801949356 1.19049314827378 0.629046587414092 2.07367110301484 0.615562144267293 0.298405343484568 NA NA NA 0.0350857672766473 97.8577961258572 a3526 gain_cnaBRCA19 274 PXD101, Belinostat HDAC 4 44 2.99573227355399 NA -0.0782167411164049 0.739659717518801 -0.817876458635206 0.669918669116114 1.53015694832682 0.549176289016125 1.22085933164739 0.534504947044503 0.298479623901937 NA NA NA 0.0879256750265713 97.8577961258572 a3527 gain_cnaBRCA30_(CRNKL1,FOXA2) 1054 PD-0332991 CDK4, CDK6 4 38 1.38629436111989 0.693147180559945 3.6134568197944 2.8060045192127 0.807452300581701 2.1265844096251 1.39003795179123 0.553716587005036 0.379694451312209 0.580885075505459 0.298489050825959 NA NA NA 0.50726341251131 97.8577961258572 a3528 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 151 QS11 ARFGAP 6 42 2.32630161961136 NA 4.35248728153247 3.67587312293032 0.676614158602153 1.38062596284845 1.48545278010587 0.458902029560821 0.490077817460561 0.455493548946019 0.298532249593754 NA NA NA 0.304068364771731 97.8577961258572 a3529 loss_cnaBRCA18 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 15 32 2.77258872223978 NA 4.78234951064861 5.11803521991734 -0.335685709268727 0.989867227966378 1.03369529207596 0.329019229916538 0.339121954727578 0.324743386026817 0.298660917956157 NA NA NA 0.29426577875524 97.8577961258572 a3530 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 135 Gemcitabine DNA replication 6 41 0.0237165266173161 NA -1.37800609826571 -0.113840944096012 -1.2641651541697 2.60039152582965 2.7695121596761 0.45949016576261 0.486144160066961 0.456457701315001 0.298768783942629 NA NA NA 0.30774721129984 97.8577961258572 a3531 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 230 GSK429286A ROCK2 6 43 2.99573227355399 2.32630161961136 5.76436241888038 5.35543026049945 0.408932158380932 0.371732382286108 0.936194598189494 0.45779546084123 1.10007138970797 0.436802518591503 0.298873927087913 NA NA NA 0.0670431860419415 97.8577961258572 a3532 gain_cnaBRCA30_(CRNKL1,FOXA2) 1049 PD-173074 FGFR1, FGFR3 4 39 0.693147180559945 NA 3.50750411678379 2.87932910509054 0.628175011693245 1.51383146574971 1.10202111778433 0.552377033531512 0.414957031813412 0.570020847655098 0.298907865353482 NA NA NA 0.472636702021145 97.8577961258572 a3533 gain_cnaBRCA13_(FGFR1,WHSC1L1) 110 Roscovitine CDKs 3 10 2.77258872223978 NA 3.52610215952556 4.2462005086814 -0.720098349155847 1.63868385373906 0.796315172161818 0.717570747227208 0.439437019845389 0.904288118988039 0.298986335153327 NA NA NA 0.529981728992706 97.8577961258572 a3534 gain_cnaBRCA64_(SDHC) 344 THZ-2-49 CDK9 8 41 2.99573227355399 NA 2.28371357010369 1.68801868811117 0.595694881992511 1.73929943565295 1.41477137538806 0.405880622586814 0.342491275384609 0.421053812902538 0.299034615580634 NA NA NA 0.385984995092088 97.8577961258572 a3535 gain_cnaBRCA64_(SDHC) 328 SNX-2112 HSP90 8 40 0.940007258491471 NA -0.271103223892018 0.554908592889675 -0.826011816781693 2.10473750524535 2.01765800504309 0.406671976991033 0.392453602752427 0.409391390769445 0.299193115354087 NA NA NA 0.332268293091672 97.8577961258572 a3536 PIK3CA_mut 136 Mitomycin C DNA crosslinker 17 31 2.77258872223978 NA -0.435596571124442 0.0309189675711864 -0.466515538695628 1.89269955823399 1.18875636063641 0.316864057293704 0.246481559456228 0.392439993713998 0.299238146504925 NA NA NA 0.366328672021978 97.8577961258572 a3537 gain_cnaBRCA61_(NOTCH2) 219 AT-7519 CDK9 3 46 2.32630161961136 NA 0.61256226997947 1.74109430119587 -1.1285320312164 2.19776831155916 1.78502905319918 0.625392997684326 0.513489991315684 0.632220539600636 0.299301550574982 NA NA NA 0.469192555568634 97.8577961258572 a3538 POLR2B_mut 312 AV-951 VEGFR 3 45 -2.05572501506252 NA 0.25739536543556 0.657267880615603 -0.399872515180044 0.429379827136216 0.646802209162813 0.625886818282455 0.931279230901522 0.618229977441818 0.299365267443676 NA NA NA 0.241341778712081 97.8577961258572 a3539 loss_cnaBRCA22_(SYNCRIP,ZNF292) 41 S-Trityl-L-cysteine KIF11 3 9 1.63315443905142 NA 0.348519166698537 1.51602140791003 -1.16750224121149 0.960486126663843 1.72374303324508 0.729469700173894 1.21553264414833 0.677306430653746 0.299520693146648 NA NA NA 0.189143946010827 97.8577961258572 a3540 MLL3_mut 203 BMS-345541 IKBKB 3 46 2.77258872223978 NA 2.94327078543878 3.57074919065471 -0.627478405215932 0.39042720293912 1.02276732753856 0.624975192804062 1.60715851890519 0.613510412701639 0.299620810076777 NA NA NA 0.0792645936005563 97.8577961258572 a3541 gain_cnaBRCA19 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 4 39 1.6094379124341 NA 3.69517136107206 2.86905892935776 0.826112431714299 1.17191247014311 1.52091863544198 0.551425006601392 0.704926735367376 0.5431667496626 0.299730514072928 NA NA NA 0.26103261291277 97.8577961258572 a3542 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1031 Elesclomol HSP70 5 39 -1.6094379124341 NA -2.19207176946104 -3.07828513481558 0.886213365354537 0.530375327843752 1.86017289962358 0.498732353436842 1.6709174028842 0.476414512615398 0.29975634867964 NA NA NA 0.029995408473767 97.8577961258572 a3543 gain_cnaBRCA63 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 7 42 1.63315443905142 NA 3.94196037207224 3.51577298588044 0.426187386191796 1.22524893316621 0.957643506391218 0.427977094047056 0.34783738606527 0.445037619267988 0.299849768372086 NA NA NA 0.40865143179746 97.8577961258572 a3544 gain_cnaBRCA15 1039 SL 0101-1 RSK, AURKB, PIM3 20 23 2.30258509299405 NA 4.48403994588024 4.79212263156937 -0.308082685689136 1.03933155111959 0.885123303764978 0.32102932383888 0.296423874900424 0.348067534069739 0.299867940347639 NA NA NA 0.305846010137081 97.8577961258572 a3545 gain_cnaBRCA62 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 6 37 1.6094379124341 NA 2.35053115608608 3.04245396628984 -0.691922810203764 2.95659997498936 1.15852225005263 0.461843752179363 0.234026522376013 0.597246026282476 0.3001447675139 NA NA NA 0.594574524726605 97.8577961258572 a3546 gain_cnaBRCA63 1133 JNJ-26854165 MDM2 6 37 2.30258509299405 NA 3.31375910934848 2.91287902487452 0.400880084473964 1.20103930478038 0.811224560315789 0.461745043464635 0.333777656466677 0.494166602053952 0.300246723634557 NA NA NA 0.461369534908548 97.8577961258572 a3547 gain_cnaBRCA12_(TERT) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 10 35 2.30258509299405 NA 2.79786971730799 3.28515190990731 -0.48728219259932 0.572992879851933 1.42780906737883 0.375871964846882 0.850415790027336 0.341279659677378 0.300376724669195 NA NA NA 0.11471365079228 97.8577961258572 a3548 loss_cnaBRCA42 172 Embelin XIAP 3 45 3.46573590279973 NA 3.55727370280875 2.95544807826246 0.601825624546286 0.545772433816324 0.978488643043755 0.624479565278198 1.10270432740256 0.615056320607059 0.300440426756119 NA NA NA 0.183246691918166 97.8577961258572 a3549 BRCA1_mut 1527 GDC0941 (rescreen) PI3K 4 41 1.38629436111989 NA 1.55619013671953 0.924506154011818 0.631683982707716 0.830403166854758 1.17141099665581 0.548859371469705 0.760695536723791 0.539250514559852 0.30058658570306 NA NA NA 0.232047125104605 97.8577961258572 a3550 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 6 43 3.68887945411394 NA 2.98299522948606 3.5259418801937 -0.542946650707636 0.620750213401627 1.24079067924247 0.456149630410636 0.874662044387165 0.437581180928211 0.300594596659392 NA NA NA 0.11236528633904 97.8577961258572 a3551 loss_cnaBRCA24 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 3 45 2.07944154167984 NA 3.89089443652061 3.16919738510264 0.721697051417967 1.76192099083403 1.12090488956996 0.624203379530246 0.409608067088379 0.643852175267829 0.300651747866382 NA NA NA 0.553057663284762 97.8577961258572 a3552 POLR2B_mut 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 3 45 2.32630161961136 NA 4.55302137603777 4.98552167197314 -0.432500295935367 0.0909194708523736 0.708239960451206 0.624160037509252 4.75696010855166 0.610669151822257 0.300684919919343 NA NA NA 0.000970004000950804 97.8577961258572 a3553 gain_cnaBRCA13_(FGFR1,WHSC1L1) 288 KIN001-055 JAK3, MNK1 11 38 2.32630161961136 NA 4.57565300855195 4.27050419467275 0.3051488138792 0.690102070422014 0.89039596075972 0.358267714550782 0.442179247038912 0.342711363626173 0.300728131894865 NA NA NA 0.241928491273085 97.8577961258572 a3554 loss_cnaBRCA22_(SYNCRIP,ZNF292) 293 MP470 PDGFR 18 30 2.99573227355399 NA 3.2073362199314 3.72613454879539 -0.518798328863984 2.02508655788185 1.40735871433151 0.312039517361716 0.256185755045762 0.368632619090586 0.300746922597563 NA NA NA 0.347050211103119 97.8577961258572 a3555 BRCA2_mut 1194 SB-505124 TGFR1 (ALK5) 5 42 2.30258509299405 NA 3.98447445580161 4.43715678370259 -0.452682327900978 1.02224144529198 0.902882788324072 0.495209018793072 0.442833080174792 0.501374412886135 0.300798013636106 NA NA NA 0.388980267883279 97.8577961258572 a3556 gain_cnaBRCA63 192 LFM-A13 BTK 6 42 2.77258872223978 NA 5.12842437489203 4.74790523131486 0.380519143577163 1.57387346278368 0.690594163149485 0.456661027254618 0.241772386773805 0.551002548069316 0.300870408716871 NA NA NA 0.583141187134179 97.8577961258572 a3557 loss_cnaBRCA17 258 STF-62247 stimulates autophagy 11 38 2.32630161961136 NA 4.36493632586899 4.7078158626096 -0.342879536740614 1.03804322958341 0.934383265055674 0.358143988430855 0.330313350127257 0.366958131169209 0.300893185128038 NA NA NA 0.339762113106551 97.8577961258572 a3558 NF1_mut 211 TL-2-105 CRAF 5 44 2.32630161961136 1.63315443905142 3.42718251507681 3.96214137532001 -0.534958860243198 1.81518792004726 0.988691004748698 0.493571862085145 0.294712659959345 0.541077907732327 0.300985693040361 NA NA NA 0.550066354612973 97.8577961258572 a3559 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 38 AZD-0530 SRC, ABL1 5 9 0.693147180559945 NA 2.83563109900601 2.44806492050885 0.387566178497153 0.914195660827217 0.449811854140283 0.602730228928702 0.423942264335908 0.861618418745101 0.30111412863723 NA NA NA 0.413457685746872 97.8577961258572 a3560 PTEN_mut 1494 SN-38 TOP1 8 40 -2.99573227355399 NA -3.869644656407 -3.19061728062691 -0.679027375780099 1.51347705169099 1.70408055074362 0.40503300737102 0.448653896021369 0.398471407636094 0.301122118390252 NA NA NA 0.281413412305603 97.8577961258572 a3561 gain_cnaBRCA10_(MDM2,NUP107) 175 PAC-1 CASP3 agonist 4 44 0.940007258491471 NA 3.01085006854447 2.34597559436253 0.664874474181944 0.983299407911921 1.23221988689852 0.546081003586214 0.676166861112866 0.539574536372256 0.301179326453312 NA NA NA 0.275959379457976 97.8577961258572 a3562 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 164 JQ12 HDAC 5 42 1.63315443905142 NA 0.855311441103106 1.66390361537955 -0.808592174276443 1.47632162389 1.64903892145205 0.494725615276663 0.547707329616877 0.490341473301579 0.301264484253372 NA NA NA 0.302418082439549 97.8577961258572 a3563 loss_cnaBRCA33 1239 YK 4-279 RNA helicase A 5 37 2.30258509299405 NA 2.57984162712444 1.93702737380138 0.642814253323059 1.25332708819347 1.29215865388842 0.498952261967247 0.512886268379953 0.497473163522665 0.301304491854064 NA NA NA 0.330593944837702 97.8577961258572 a3564 TP53_mut 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 35 10 2.30258509299405 NA 3.28493259979798 2.79863730269062 0.486295297107363 1.14462883516385 1.75531325884744 0.375091316218832 0.42484976978389 0.277041886772205 0.30136915671184 NA NA NA 0.425245886935753 97.8577961258572 a3565 gain_cnaBRCA62 1 Erlotinib EGFR 5 7 0.693147180559945 NA 3.13423445059509 2.77824269739767 0.355991753197418 0.339500824153891 0.66474032915299 0.638113177243729 1.04857404716064 0.535535061715033 0.301371320937541 NA NA NA 0.255103657082464 97.8577961258572 a3566 gain_cnaBRCA47_(EGFR) 1049 PD-173074 FGFR1, FGFR3 6 37 0.693147180559945 NA 3.38859289206988 2.86465660035803 0.523936291711858 0.672619223563777 1.18762656633627 0.460653813193492 0.77894932728187 0.441162488751122 0.30137544934722 NA NA NA 0.148363930714867 97.8577961258572 a3567 loss_cnaBRCA22_(SYNCRIP,ZNF292) 165 DMOG Prolyl-4-Hydroxylase 17 29 8.29404964010203 NA 7.87769463383148 7.38959647611641 0.488098157715076 1.57470218157275 1.50126806031273 0.319356616202897 0.309962203283152 0.32512392064972 0.301505738776566 NA NA NA 0.30960712231583 97.8577961258572 a3568 gain_cnaBRCA58_(CCND1) 204 Tipifarnib Farnesyl-transferase (FNTA) 9 39 2.77258872223978 NA 2.09329323504022 1.51074959499235 0.582543640047871 1.11603519026448 1.57788257990683 0.38636412479448 0.521976049796259 0.369193276778725 0.301578734431208 NA NA NA 0.21317380819741 97.8577961258572 a3569 loss_cnaBRCA33 274 PXD101, Belinostat HDAC 6 42 2.99573227355399 NA 0.0773649734358862 0.756380256327293 -0.679015282891407 1.2000170944385 1.52105274586292 0.455863925598047 0.565838008506974 0.446411398117684 0.301705098437997 NA NA NA 0.248851759793615 97.8577961258572 a3570 ARID1A_mut 1194 SB-505124 TGFR1 (ALK5) 5 42 2.30258509299405 NA 3.98532671078812 4.43705532477563 -0.451728613987512 0.938054045744584 0.9118070127719 0.494140387730559 0.48155926200281 0.495421298213373 0.301829878160125 NA NA NA 0.354622384116827 97.8577961258572 a3571 gain_cnaBRCA64_(SDHC) 167 OSU-03012 PDPK1 (PDK1) 8 40 2.77258872223978 NA 2.6453714791709 2.16850053726699 0.476870941903912 1.4066543929578 1.1334937611454 0.404418935491797 0.339010736604025 0.420708925139591 0.301847055622367 NA NA NA 0.390749943452351 97.8577961258572 a3572 gain_cnaBRCA8_(CHD4,WNK1) 1494 SN-38 TOP1 3 45 -2.99573227355399 NA -4.28203323102565 -3.23857219518345 -1.0434610358422 2.66416467267658 1.61739160710959 0.622386166510615 0.391665367589265 0.645150519673435 0.302044723212058 NA NA NA 0.568881178530286 97.8577961258572 a3573 PIK3CA_mut 312 AV-951 VEGFR 16 32 -2.05572501506252 NA 0.768323517564019 0.564252013843266 0.204071503720753 0.663158826070327 0.626950476804875 0.319369207569462 0.307726438521549 0.325498601996064 0.302373490311728 NA NA NA 0.314729321459597 97.8577961258572 a3574 loss_cnaBRCA20 281 CH5424802 ALK 3 45 1.63315443905142 NA 4.19356355775594 3.53401803060007 0.659545527155866 0.579843823613123 1.0773591150386 0.621865413897264 1.13745374236481 0.612187262305975 0.302444719958 NA NA NA 0.173176868920909 97.8577961258572 a3575 gain_cnaBRCA62 87 GW843682X PLK1 4 8 -1.36257783450257 NA -2.75436053865132 -1.49487309190164 -1.25948744674968 1.19437888433718 2.12176940386355 0.665725254250149 1.0545124861686 0.593602417141218 0.302489967411327 NA NA NA 0.219382799307155 97.8577961258572 a3576 gain_cnaBRCA14_(RAD21) 205 BMS-708163 g-secretase 21 27 2.32630161961136 0.940007258491471 4.78113295308226 4.98628240114868 -0.205149448066422 0.774337463340676 0.589753185330873 0.303373761378733 0.264935454861448 0.347856447695701 0.302547870865713 NA NA NA 0.320181744541874 97.8577961258572 a3577 gain_cnaBRCA10_(MDM2,NUP107) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 3 43 0 NA -0.540229182459107 0.736478703180546 -1.27670788563965 2.67784799835728 2.01606686120755 0.622545653201561 0.476766375994025 0.633266639219967 0.302862042423721 NA NA NA 0.497484031081553 97.8577961258572 a3578 gain_cnaBRCA62 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 8 39 2.99573227355399 NA 3.37050385088345 3.94554102836447 -0.57503717748102 1.21314406262961 1.45675609419631 0.404498448544245 0.474005680936665 0.394738130680874 0.302892357874255 NA NA NA 0.262550834793574 97.8577961258572 a3579 gain_cnaBRCA10_(MDM2,NUP107) 288 KIN001-055 JAK3, MNK1 5 44 2.32630161961136 NA 3.96299942532564 4.38173512193199 -0.418735696606348 1.15526516194666 0.817892042402013 0.491576130118374 0.362458516364126 0.511969398035211 0.302922201433384 NA NA NA 0.47023651940672 97.8577961258572 a3580 ASH1L_mut 1016 Temsirolimus MTOR 3 41 -1.6094379124341 NA -0.88387963477566 -1.81438447065233 0.930504835876674 1.36068823184429 1.49798131789492 0.623775594972631 0.683848668710434 0.621172523823123 0.302947457768098 NA NA NA 0.358008515316442 97.8577961258572 a3581 gain_cnaBRCA64_(SDHC) 346 THZ-2-102-1 CDK7 8 40 0.916290731874155 2.99573227355399 -0.483383455929634 -1.50551247522863 1.022129019299 3.13836725425329 2.40975249698583 0.403337400631917 0.325688148164862 0.424163485908822 0.303126767661621 NA NA NA 0.406947968569364 97.8577961258572 a3582 MLL3_mut 308 XL-880 MET 3 46 1.63315443905142 NA 0.917207843752469 1.90841538032237 -0.991207536569897 0.766424440073559 1.62504269744825 0.620306434154902 1.29328800693616 0.60995784180093 0.303204321803057 NA NA NA 0.134277699112674 97.8577961258572 a3583 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 154 CHIR-99021 GSK3B 6 41 0.940007258491471 NA 2.91715837448254 3.32786785702802 -0.410709482545478 0.622574835995026 0.931273910007181 0.45522845289469 0.65969496163311 0.441018993587302 0.303219340378635 NA NA NA 0.19544280973069 97.8577961258572 a3584 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 231 FMK RSK 15 34 2.99573227355399 2.32630161961136 5.45690975083321 5.64760614436792 -0.190696393534714 0.504785449821624 0.624042955115061 0.322644858641524 0.377777120164815 0.305582159003067 0.303243941289447 NA NA NA 0.266333051050296 97.8577961258572 a3585 PIK3CA_mut 165 DMOG Prolyl-4-Hydroxylase 16 30 8.29404964010203 NA 7.89140821229631 7.39855250619233 0.492855706103975 1.8141027329144 1.35742724148429 0.322440200116661 0.27168015193505 0.363080753827407 0.30329788733901 NA NA NA 0.349709497727807 97.8577961258572 a3586 gain_cnaBRCA64_(SDHC) 1091 BMS-536924 IGF1R 9 38 1.38629436111989 NA 3.36344947392207 2.94274102728531 0.420708446636762 0.702070504019922 1.15679283707356 0.386003536504029 0.599239598057268 0.363685210656269 0.303321239111531 NA NA NA 0.176232482899155 97.8577961258572 a3587 gain_cnaBRCA63 1018 ABT-888 PARP1, PARP2 6 39 1.6094379124341 NA 4.66497494749154 4.36278407579584 0.302190871695696 1.24290740356906 0.540236459807391 0.456844150583525 0.243132248490872 0.559367784624229 0.303342689493837 NA NA NA 0.581296830631978 97.8577961258572 a3588 gain_cnaBRCA63 238 CAL-101 PI3Kdelta 7 42 2.99573227355399 2.32630161961136 4.37609887322817 4.77610844379933 -0.400009570571156 0.716364145636483 0.970300504621256 0.424772239574596 0.558388597485922 0.412253285107066 0.303442136500803 NA NA NA 0.224871286655324 97.8577961258572 a3589 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1039 SL 0101-1 RSK, AURKB, PIM3 5 38 2.30258509299405 NA 4.22828821181638 4.7041625890689 -0.475874377252523 1.1074041953318 0.942525570671296 0.495775361464237 0.429720583738572 0.504892802975722 0.303451499620717 NA NA NA 0.402383292674397 97.8577961258572 a3590 loss_cnaBRCA22_(SYNCRIP,ZNF292) 291 KIN001-266 MAP3K8 (COT) 19 30 2.99573227355399 NA 3.99812538451375 3.63962345777886 0.358501926734889 1.35668969668745 1.04685349111172 0.30505463525186 0.264247548728513 0.342456637704074 0.30345835741543 NA NA NA 0.333838502221903 97.8577961258572 a3591 BRCA1_mut 260 NG-25 MAP3K7 (TAK1) 4 45 2.32630161961136 NA 3.84648318048228 3.15161986904804 0.694863311434238 1.3772366729971 1.27321512678923 0.542816426763963 0.504534423936082 0.54575483499519 0.303486782872401 NA NA NA 0.39345221655006 97.8577961258572 a3592 loss_cnaBRCA42 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 3 45 0.246860077931526 2.32630161961136 -1.22265950818441 -0.201104695575308 -1.0215548126091 0.741869194236141 1.67621845003982 0.620381411667073 1.37700125648288 0.609440143428106 0.303586596770221 NA NA NA 0.11673362997806 97.862728396503 a3593 PIK3CA_mut 154 CHIR-99021 GSK3B 16 31 0.940007258491471 NA 3.46594508893688 3.177110031034 0.288835057902883 1.02344108491476 0.835061855469807 0.320132565439151 0.282219526028643 0.345884626403375 0.303908405735458 NA NA NA 0.339234966077063 97.9258263913341 a3594 loss_cnaBRCA28_(GPS2) 222 BX-912 PDPK1 (PDK1) 4 45 2.32630161961136 NA 4.63364684126203 3.81712601885717 0.816520822404858 1.06521563706097 1.53120163265162 0.542260375926787 0.766531013999864 0.533254931939217 0.303976795627647 NA NA NA 0.228459158372856 97.9258263913341 a3595 loss_cnaBRCA7_(FAS,PTEN) 158 PF-562271 FAK 4 41 0.940007258491471 NA 2.97023946636008 2.27110491181652 0.699134554543551 0.522487575280986 1.32284772547794 0.544790123501004 1.33808838261382 0.528507205385983 0.304139812216387 NA NA NA 0.0703768749726703 97.9258263913341 a3596 loss_cnaBRCA29_(MAP2K4) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 6 39 2.30258509299405 NA 0.931512984497969 1.43206417392047 -0.500551189422498 1.60046129156057 1.01291340568535 0.4560770629161 0.312754324057675 0.494169774645068 0.30414529989564 NA NA NA 0.487008252232366 97.9258263913341 a3597 POLR2B_mut 152 CP466722 ATM 3 46 2.77258872223978 NA 2.11582786425146 2.77020571044414 -0.654377846192678 1.12800824382541 1.05389088407564 0.619001492086166 0.580117964362997 0.62091612716304 0.304211169140654 NA NA NA 0.422075519443391 97.9258263913341 a3598 loss_cnaBRCA20 176 IPA-3 PAK1, PAK2, PAK3 3 44 3.46573590279973 NA 5.3693226856943 4.43735195666112 0.931970729033186 1.13084879937794 1.518318000906 0.619983159959496 0.824133809529484 0.613817875094063 0.304352781890669 NA NA NA 0.286274816046643 97.9258263913341 a3599 PTEN_mut 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 8 39 2.99573227355399 NA 3.37194671901389 3.94524505541463 -0.573298336400739 1.49217005151604 1.40834487249227 0.403245909525854 0.384204424836345 0.407072406481096 0.30437434077417 NA NA NA 0.341879882177191 97.9258263913341 a3600 gain_cnaBRCA27_(CLTC,PPM1D) 155 AP-24534 ABL 9 38 -0.669430653942629 NA 1.79720172488167 1.36202876944795 0.435172955433716 0.902666999636189 1.17346217319393 0.385083813005941 0.482096892441076 0.370845320262231 0.304461222148496 NA NA NA 0.240285252447574 97.9265692015954 a3601 loss_cnaBRCA23 1373 Dabrafenib BRAF 3 43 2.30258509299405 NA 5.15863400769193 4.14872553552405 1.00990847216788 0.25228150626344 1.66563346388906 0.620250585408618 4.00310148423366 0.606320954797498 0.304626502654058 NA NA NA 0.00221497990909389 97.9333048633374 a3602 gain_cnaBRCA16 104 Bortezomib Proteasome 3 11 -3.91202300542815 NA -5.52549507565618 -4.31177432406331 -1.21372075159288 2.00486873426524 1.67915565590043 0.698469518718013 0.605386642451527 0.722816105420574 0.304651320595683 NA NA NA 0.411704675944121 97.9333048633374 a3603 ASH1L_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 3 40 2.30258509299405 NA 3.14935452592345 3.85843785315319 -0.709083327229738 2.22658130679457 1.05422146016318 0.622145025912482 0.318462804419456 0.672613254448435 0.304747879979475 NA NA NA 0.637661530742698 97.9371552118329 a3604 ASH1L_mut 1230 IOX2 EGLN1 3 44 -2.30258509299405 NA -0.128027446612604 0.27520067769032 -0.403228124302924 0.878743211076313 0.63858390655689 0.619263644348209 0.458869120375948 0.631441099850206 0.304907764716281 NA NA NA 0.51175886694204 97.9613487139239 a3605 POLR2B_mut 1018 ABT-888 PARP1, PARP2 3 42 1.6094379124341 NA 4.02042717470417 4.43040826468749 -0.409981089983313 0.748876012875639 0.656992293728733 0.619728984757585 0.547461906823547 0.624027243388931 0.305530172759063 NA NA NA 0.444751208479924 98.0306386144711 a3606 loss_cnaBRCA22_(SYNCRIP,ZNF292) 282 EKB-569 EGFR 17 30 0.916290731874155 2.99573227355399 2.00122563790496 1.33827781341565 0.662947824489304 1.95395225005799 2.18724827311662 0.314601853236324 0.339285581042028 0.303096741525674 0.30558593082359 NA NA NA 0.291733281861934 98.0306386144711 a3607 gain_cnaBRCA62 201 Epothilone B Microtubules 9 39 -3.44201937618241 NA -3.6763747531258 -4.36484634899936 0.68847159587356 2.14032469124419 1.71648833852893 0.383039053720141 0.321666894135275 0.401093080809156 0.305710028123695 NA NA NA 0.388044480306241 98.0306386144711 a3608 gain_cnaBRCA14_(RAD21) 106 XMD8-85 MAP2K5 (ERK5) 6 7 2.07944154167984 NA 2.83844466198974 3.55457888314968 -0.716134221159939 1.00312688533343 1.33941309445494 0.597618899531087 0.713901931680259 0.534662699748627 0.305740074882698 NA NA NA 0.295229717430363 98.0306386144711 a3609 gain_cnaBRCA61_(NOTCH2) 293 MP470 PDGFR 3 45 2.99573227355399 NA 4.49405744178282 3.4674203577173 1.02663708406552 0.558098731287924 1.69622818035852 0.617332790102119 1.83952592348016 0.605247039256551 0.305941654500552 NA NA NA 0.0528073626046328 98.0306386144711 a3610 gain_cnaBRCA64_(SDHC) 194 AUY922 HSP90 8 39 -1.36257783450257 NA -1.8200125485655 -2.51143620840211 0.691423659836606 2.54604800132401 1.52040947443814 0.401853131447161 0.271567409364257 0.454761478049929 0.306028086489587 NA NA NA 0.479470489286407 98.0306386144711 a3611 gain_cnaBRCA63 1259 BMN-673 PARP1 6 40 2.30258509299405 NA 3.91684065817435 3.21384264784493 0.702998010329416 0.774910060731246 1.62338527900813 0.453392213074092 0.90719948798449 0.433044465426556 0.306037490791746 NA NA NA 0.108042405157138 98.0306386144711 a3612 gain_cnaBRCA64_(SDHC) 263 FR-180204 ERK 8 41 2.99573227355399 NA 5.11349284560766 5.4055711418111 -0.292078296203448 1.32141457604093 0.566675203829785 0.399935742470432 0.221034565154063 0.515424522247458 0.306087594837923 NA NA NA 0.55719100014159 98.0306386144711 a3613 gain_cnaBRCA14_(RAD21) 179 5-Fluorouracil DNA antimetabolite 21 28 3.46573590279973 NA 3.76638393030908 4.24779625636261 -0.481412326053535 1.70054442903814 1.54316869423664 0.298639900452454 0.28309305998305 0.311963512382991 0.30618742185957 NA NA NA 0.313735818359257 98.0306386144711 a3614 loss_cnaBRCA7_(FAS,PTEN) 1047 Nutlin-3a MDM2 4 39 2.07944154167984 1.38629436111989 4.70061146108959 4.15631206620924 0.544299394880352 0.742033047612649 1.01831228240019 0.543925968629049 0.733524465832799 0.534511273494044 0.306265176361557 NA NA NA 0.246372996329056 98.0306386144711 a3615 loss_cnaBRCA33 1024 CEP-701 FLT3, JAK2, NTRK1, RET 5 40 0.693147180559945 NA 0.00152045488278452 0.703574980789821 -0.702054525907036 1.63514662880867 1.40689265983277 0.491062699245136 0.429352642471298 0.499010724805748 0.306338894732084 NA NA NA 0.402410159844657 98.0306386144711 a3616 loss_cnaBRCA36_(FAT1,IRF2) 1494 SN-38 TOP1 10 38 -2.99573227355399 NA -3.79163001528767 -3.17540916640673 -0.616220848880942 1.46350914534933 1.72483420430767 0.367473382587081 0.421057053752716 0.357263815468157 0.306567642568872 NA NA NA 0.271035064229587 98.0306386144711 a3617 gain_cnaBRCA19 219 AT-7519 CDK9 4 45 2.32630161961136 NA 0.778026035270034 1.75146490053041 -0.973438865260373 1.06426302064602 1.84485222482176 0.539259227497519 0.91466004772907 0.527651403274004 0.306630880971189 NA NA NA 0.167575929373587 98.0306386144711 a3618 gain_cnaBRCA58_(CCND1) 1036 PLX4720 BRAF 8 35 2.30258509299405 NA 4.99186473513934 4.50627303791101 0.485591697228328 0.63353187442618 1.28261925401761 0.405680207913486 0.766483450683758 0.378593799919411 0.306638196167033 NA NA NA 0.133409582342329 98.0306386144711 a3619 loss_cnaBRCA17 1013 Nilotinib ABL 8 32 0.693147180559945 NA 2.89073702797708 3.28094997101268 -0.390212943035603 1.22613238517865 0.879813604560925 0.409409438413148 0.318246991721654 0.443517741727057 0.306873125874164 NA NA NA 0.419087592993148 98.0306386144711 a3620 loss_cnaBRCA28_(GPS2) 1264 SGC0946 Q8TEK3 (DOT1L) 4 42 -0.693147180559945 NA 2.24916964708959 1.92228928391459 0.326880363175003 0.367235988638867 0.618271471903398 0.540766207709881 0.890109829340421 0.528700381676476 0.307044993779678 NA NA NA 0.177261168460808 98.0306386144711 a3621 POLR2B_mut 1006 Cytarabine DNA synthesis 3 42 0.693147180559945 NA 2.08572237605714 1.14587691041803 0.939845465639107 2.91276419184829 1.41977305353788 0.617489658535853 0.322664453329032 0.661968800786251 0.307259774447616 NA NA NA 0.633518746285211 98.0306386144711 a3622 ARID1A_mut 1262 UNC1215 LMBL3 5 41 0 NA 2.49954341403165 2.78898090689623 -0.289437492864574 0.720827742042826 0.577061214985603 0.489264767290368 0.401534896595833 0.50157155835156 0.307312784385872 NA NA NA 0.429569175191231 98.0306386144711 a3623 loss_cnaBRCA57 1166 QL-VIII-58 MTOR, ATR 5 21 2.30258509299405 NA -1.05236194763902 -1.63013781775941 0.577775870120385 0.84851121189794 1.15902935905852 0.518972578341221 0.680928975385042 0.498499771040927 0.307375884644703 NA NA NA 0.240690191150283 98.0306386144711 a3624 TP53_mut 106 XMD8-85 MAP2K5 (ERK5) 9 4 2.07944154167984 NA 3.46124553203073 2.6903775914274 0.770867940603331 1.07898683059165 1.47117816020773 0.643064299978162 0.714436839030404 0.523980005585784 0.30748300512679 NA NA NA 0.394123896802564 98.0306386144711 a3625 gain_cnaBRCA12_(TERT) 1199 Tamoxifen ER 10 37 1.6094379124341 NA 4.1440185264673 3.79488689684092 0.349131629626386 0.813399762847492 0.980376488302489 0.367764956440718 0.429225143125405 0.356119953703605 0.307650124077934 NA NA NA 0.266170359674987 98.0306386144711 a3626 loss_cnaBRCA7_(FAS,PTEN) 344 THZ-2-49 CDK9 4 45 2.99573227355399 NA 1.05971433130834 1.84976927662565 -0.79005494531731 0.581439154216453 1.50987245324579 0.538090174730868 1.35879212741011 0.52325939427461 0.307669016885992 NA NA NA 0.0661902113292752 98.0306386144711 a3627 gain_cnaBRCA13_(FGFR1,WHSC1L1) 9 MG-132 Proteasome 4 10 0 NA 1.03301113409288 0.0475813661693475 0.985429767923528 1.39956302181917 1.61466975878177 0.630203269200265 0.704098173901916 0.610298026927198 0.307732990403991 NA NA NA 0.295868515466621 98.0306386144711 a3628 loss_cnaBRCA18 226 GSK1070916 AURKB 16 33 0.940007258491471 2.32630161961136 1.9934456332793 2.60297901875104 -0.609533385471744 1.34486420465127 2.16397382927087 0.314112795451145 0.453230432755699 0.281673177940937 0.30776675044596 NA NA NA 0.233826228490197 98.0306386144711 a3629 ARID1A_mut 184 BMS-754807 IGF1R 5 43 0.940007258491471 NA 0.896911364553076 1.7117477442295 -0.814836379676428 1.10268643782602 1.71651680866448 0.487310381558612 0.738955655682955 0.474703408416025 0.307770999577289 NA NA NA 0.190853768759846 98.0306386144711 a3630 gain_cnaBRCA19 1032 Afatinib ERBB2, EGFR 4 41 -0.693147180559945 NA 1.18888057158955 0.202822052229831 0.986058519359721 1.10021238929088 1.86724713258125 0.540534425572739 0.896243787979218 0.528081421122125 0.307886623107392 NA NA NA 0.175363427423779 98.0306386144711 a3631 loss_cnaBRCA23 1072 BMS-708163 g-secretase 3 43 1.6094379124341 NA 4.23193039588055 3.64603949261163 0.58589090326892 0.213430529700344 0.972335517456542 0.616033961232879 2.74511291375001 0.602560425645571 0.307886631090082 NA NA NA 0.011381339131779 98.0306386144711 a3632 ASH1L_mut 299 OSI-027 MTORC1/2 3 45 2.99573227355399 NA 0.129420358520411 1.34493951063778 -1.21551915211737 2.52601396662552 1.94863105438245 0.614754338667781 0.481200487478369 0.623781063831288 0.307943246935905 NA NA NA 0.493968817673433 98.0306386144711 a3633 gain_cnaBRCA19 154 CHIR-99021 GSK3B 4 43 0.940007258491471 NA 2.83042779156696 3.31683305159944 -0.486405260032486 0.822456541974217 0.907857339872711 0.539003706276722 0.591405424127241 0.535772790139785 0.307997190952613 NA NA NA 0.329476749378636 98.0306386144711 a3634 gain_cnaBRCA58_(CCND1) 1028 VX-702 p38 9 36 0.693147180559945 NA 3.63624948324697 3.37447691894431 0.261772564302663 0.413451839427823 0.728434186811545 0.384419533281502 0.633139193829518 0.359363370146694 0.30807075585918 NA NA NA 0.168000268835016 98.0306386144711 a3635 gain_cnaBRCA31 59 WZ-1-84 BMX 3 9 2.32630161961136 NA 2.92749025256532 3.77336595682721 -0.845875704261891 0.417935709699293 1.30444347539421 0.715869625425558 2.02393737752274 0.64845715450128 0.308137778232238 NA NA NA 0.120014875770265 98.0306386144711 a3636 loss_cnaBRCA57 274 PXD101, Belinostat HDAC 5 43 2.99573227355399 NA 1.32110892132547 0.595967813947309 0.725141107378157 1.63151429280874 1.47580329172973 0.486675314136768 0.44445893644596 0.491353496391955 0.308394721502708 NA NA NA 0.387656798165459 98.0306386144711 a3637 loss_cnaBRCA28_(GPS2) 150 Bicalutamide ANDR (androgen receptor) 4 44 0.0237165266173161 NA 2.45645140790287 2.79041831941178 -0.333966911508913 0.976593069700105 0.58829917350677 0.537730702326189 0.341971412526477 0.567682102149121 0.308546027026798 NA NA NA 0.546392763282158 98.0306386144711 a3638 gain_cnaBRCA16 283 GSK2126458 PI3K, MTOR 16 32 -2.05572501506252 0.0237165266173161 -3.39747449031187 -2.88429961085469 -0.513174879457184 1.46542121094638 1.70080857785973 0.315257459647369 0.350189335068906 0.301724065916316 0.308568952642326 NA NA NA 0.286420433024421 98.0306386144711 a3639 loss_cnaBRCA18 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 16 33 1.63315443905142 NA 3.36626523209209 3.6786649787276 -0.31239974663551 0.850393091204195 1.05768617336442 0.313583162471289 0.367359224653551 0.295361473471652 0.308574097082413 NA NA NA 0.273956362941562 98.0306386144711 a3640 BRCA1_mut 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 4 45 1.63315443905142 NA 4.06799137581427 3.53298272240505 0.535008653409214 0.428899973141654 1.02352121671667 0.537034491956251 1.24739726489215 0.522713789095118 0.308608539489231 NA NA NA 0.0834566416878701 98.0306386144711 a3641 NF1_mut 306 TG101348 JAK2 4 44 2.32630161961136 NA 2.59492177451465 3.28215867321553 -0.687236898700879 0.999234892619193 1.2954617910375 0.53764437375289 0.687763111333608 0.530495691540613 0.308622824262141 NA NA NA 0.269696799631105 98.0306386144711 a3642 PTEN_mut 1149 TW 37 BCL2, BCL2L1 7 36 1.6094379124341 NA -0.585060800237877 -0.0563082449326493 -0.528752555305227 1.1386513330358 1.25846823718695 0.425844483159875 0.464367396730217 0.420155662003156 0.308630352173475 NA NA NA 0.297753588855168 98.0306386144711 a3643 loss_cnaBRCA7_(FAS,PTEN) 197 Bryostatin 1 PRKC 4 44 -4.8283137373023 NA -2.33235162813691 -2.84993594990453 0.517584321767627 0.201604779031543 0.99431637358412 0.537624789198463 2.56732168877131 0.520542893105481 0.308640248347903 NA NA NA 0.00873279533310384 98.0306386144711 a3644 ASH1L_mut 1032 Afatinib ERBB2, EGFR 3 42 -0.693147180559945 NA 1.33879178143872 0.215591692463456 1.12320008897526 0.31497551323092 1.8669694510909 0.615688343431855 3.56599177330906 0.601616747568609 0.308655928576704 NA NA NA 0.00382287185315878 98.0306386144711 a3645 gain_cnaBRCA12_(TERT) 1007 Docetaxel Microtubules 10 35 -4.38202663467388 NA -5.02878208250375 -4.46113610496241 -0.567645977541336 0.771127567445091 1.68245589037738 0.369298494363916 0.73612460701161 0.337391298510663 0.308804107841068 NA NA NA 0.139044040482487 98.0306386144711 a3646 PTEN_mut 1018 ABT-888 PARP1, PARP2 7 38 1.6094379124341 NA 4.16641426026981 4.4466718110289 -0.280257550759089 0.848137262020134 0.626210310041482 0.423566902242173 0.330438908074334 0.447545411286064 0.308857730433562 NA NA NA 0.431195578846148 98.0306386144711 a3647 NF1_mut 1033 Vismodegib SMO 4 41 2.30258509299405 NA 4.37682348294467 4.79713565131478 -0.420312168370111 0.71788674911344 0.783591954120355 0.539423526996661 0.585485341370597 0.536391633630217 0.308869865767027 NA NA NA 0.333952360012974 98.0306386144711 a3648 gain_cnaBRCA27_(CLTC,PPM1D) 304 SB52334 ALK5 9 40 2.99573227355399 NA 3.90893846707659 4.39030623598814 -0.481367768911551 1.32415651594732 1.25694123831492 0.37943796191656 0.363527848191854 0.38296759962851 0.308990163207882 NA NA NA 0.340520178068888 98.0306386144711 a3649 loss_cnaBRCA33 287 KIN001-244 PDPK1 (PDK1) 6 43 2.99573227355399 NA 3.10868892791009 3.52965261589632 -0.420963687986225 0.706552628288531 0.963224883971679 0.448186888626628 0.595799479234714 0.437035727576368 0.309015534180533 NA NA NA 0.2302367185462 98.0306386144711 a3650 loss_cnaBRCA33 201 Epothilone B Microtubules 6 42 -3.44201937618241 NA -4.94193155068595 -4.13487597821409 -0.807055572471866 1.80492168513109 1.79678831162432 0.448944303701301 0.447141601278533 0.449165640298649 0.30901790391469 NA NA NA 0.341940412594678 98.0306386144711 a3651 TP53_mut 266 Zibotentan, ZD4054 Endothelin A Receptor 38 11 2.99573227355399 NA 5.78079537399659 5.60815505716148 0.172640316835104 0.503354935391961 0.440357133124465 0.351875440787804 0.342979286973058 0.392046145841149 0.3093371310796 NA NA NA 0.282400080045488 98.0850358512948 a3652 gain_cnaBRCA15 171 AKT inhibitor VIII AKT1, AKT2, AKT3 22 25 0.940007258491471 NA 2.08818790610681 1.71307300197291 0.375114904133895 1.12208120710414 1.34939397538736 0.300458295871701 0.334302813164466 0.277987682601156 0.309528224757881 NA NA NA 0.303855305275583 98.0850358512948 a3653 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 40 2.30258509299405 NA 3.73920866933387 3.10657426682916 0.632634402504709 0.892889122418231 1.33154626912296 0.48776200293765 0.708525153483034 0.475112594413561 0.30956196378333 NA NA NA 0.207102579879544 98.0850358512948 a3654 gain_cnaBRCA19 281 CH5424802 ALK 4 44 1.63315443905142 NA 3.05343493751665 3.62267641591374 -0.569241478397085 2.07183443404086 0.951145795878794 0.536537452586074 0.274752397703348 0.598479729252386 0.309608689703239 NA NA NA 0.62276955622227 98.0850358512948 a3655 gain_cnaBRCA31 1006 Cytarabine DNA synthesis 14 31 0.693147180559945 NA 1.55571694893056 1.05174064776455 0.50397630116601 1.83124651546752 1.36678444189363 0.331079123413758 0.27520942533362 0.368731371032999 0.309612925154575 NA NA NA 0.368407636913689 98.0850358512948 a3656 loss_cnaBRCA22_(SYNCRIP,ZNF292) 258 STF-62247 stimulates autophagy 19 30 2.32630161961136 NA 4.8073493765903 4.51905547361693 0.288293902973376 1.08473087296487 0.869711596436103 0.301002251689328 0.26577458995464 0.331482188066417 0.309854883499106 NA NA NA 0.336015633468239 98.0909318875199 a3657 gain_cnaBRCA16 1166 QL-VIII-58 MTOR, ATR 10 16 2.30258509299405 NA -1.23254571706842 -1.69807792127865 0.465532204210231 1.5386175415275 0.750788342596492 0.418050831608832 0.302565252017121 0.620057848261543 0.310045987150737 NA NA NA 0.389988779687137 98.0909318875199 a3658 gain_cnaBRCA63 228 KIN001-102 AKT1 7 42 2.32630161961136 NA 1.44051257044176 2.02756876690317 -0.587056196461407 1.15646651077234 1.43394731128162 0.418851234575782 0.507629223149181 0.409398721865669 0.310156461458127 NA NA NA 0.260209999550054 98.0909318875199 a3659 loss_cnaBRCA28_(GPS2) 1175 AG-014699 PARP1, PARP2 4 39 1.6094379124341 NA 4.36159912825111 3.81028567627625 0.551313451974862 0.283273223100693 1.05870797984597 0.539384780921672 1.94622508241413 0.52074175548868 0.310269632787112 NA NA NA 0.0244732692786208 98.0909318875199 a3660 gain_cnaBRCA58_(CCND1) 1049 PD-173074 FGFR1, FGFR3 8 35 0.693147180559945 NA 2.56487974484533 3.02299467448296 -0.458114929637627 1.67337006905067 0.992442047555716 0.402590380048645 0.273767852138961 0.461603708514687 0.310290070693028 NA NA NA 0.477199148219674 98.0909318875199 a3661 loss_cnaBRCA60 178 BAY 61-3606 SYK 3 45 2.07944154167984 NA 4.01365701869591 3.03455920852465 0.979097810171266 0.214875241705279 1.63584516586168 0.611739081310412 4.55658735925559 0.598527189861228 0.310295250997678 NA NA NA 0.00127558431330674 98.0909318875199 a3662 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 266 Zibotentan, ZD4054 Endothelin A Receptor 6 43 2.99573227355399 NA 5.5495877526539 5.76889310057496 -0.219305347921058 0.628456397701667 0.47157093142635 0.44696798179756 0.34895873241657 0.465052727609248 0.310318652479908 NA NA NA 0.442929503820671 98.0909318875199 a3663 PIK3CA_mut 345 KIN001-270 CDK9 17 32 2.99573227355399 NA 5.24580874509846 5.03415667981195 0.211652065286508 0.759936917078436 0.647397806657939 0.307732460968489 0.278512677210367 0.326927374652563 0.310443722696171 NA NA NA 0.337479199477202 98.0909318875199 a3664 gain_cnaBRCA15 299 OSI-027 MTORC1/2 22 26 2.99573227355399 NA 0.950741613538125 1.53823936755471 -0.587497754016587 1.96613075275352 1.98695689688874 0.297094680200069 0.298809096594318 0.295677150790999 0.310449719120666 NA NA NA 0.310157889067169 98.0909318875199 a3665 gain_cnaBRCA16 290 KIN001-260 IKK 16 33 2.99573227355399 NA 5.2624069302354 4.93821506763033 0.324191862605066 0.892357027717865 1.09980839275218 0.312289157858886 0.36329838006001 0.294771220824932 0.310552690302123 NA NA NA 0.277428796404123 98.0909318875199 a3666 loss_cnaBRCA33 299 OSI-027 MTORC1/2 6 42 2.99573227355399 NA 0.494666240326616 1.37958432410242 -0.884918083775803 1.41382176456196 2.03557666168851 0.447496279251501 0.625904980356542 0.434725992113589 0.310563396061532 NA NA NA 0.213658497978569 98.0909318875199 a3667 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 303 PIK-93 PI4K, PI3K 6 43 2.99573227355399 NA 2.23621227106813 2.86901300365821 -0.632800732590084 0.894080545112569 1.46661081840682 0.446658490119057 0.707767030665466 0.431471474673489 0.31065012146938 NA NA NA 0.172383937435624 98.0915668528484 a3668 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 235 QL-XII-47 BTK, BMX 9 40 2.32630161961136 NA 1.24570322631868 1.81210876523356 -0.566405538914875 0.976059117181608 1.5847491624388 0.377930305471284 0.580298394784103 0.357410215029376 0.310895273132175 NA NA NA 0.183885920668425 98.1422128570735 a3669 gain_cnaBRCA16 3 Rapamycin MTOR 3 11 -2.30258509299405 NA -4.15489983237204 -2.35696276237309 -1.79793706999895 4.26123287873813 2.13181077961602 0.688792387590793 0.42192884575024 0.843384922897702 0.311106736076191 NA NA NA 0.54482750805546 98.1435792383088 a3670 loss_cnaBRCA17 1129 PF-4708671 RPS6KB1 (p70S6KA) 9 34 2.30258509299405 NA 4.15551407998511 3.71723385247153 0.438280227513585 0.743735155656465 1.21693010348784 0.384413564799983 0.589296101146022 0.360152342568757 0.311151456947951 NA NA NA 0.190736463438388 98.1435792383088 a3671 loss_cnaBRCA33 1020 Lenalidomide TNFA 5 40 1.6094379124341 NA 3.94911220233145 4.29292837370323 -0.343816171371783 0.298878795149529 0.736678825933388 0.485975877620669 1.15035317644322 0.466711081231581 0.311315719533992 NA NA NA 0.0769839340038238 98.1435792383088 a3672 PIK3CA_mut 1375 Temozolomide DNA akylating agent 16 30 3.40119738166216 NA 6.04389582946542 5.82344865859047 0.220447170874943 0.665137956665256 0.710470765520119 0.317031198671462 0.331430748562568 0.310283239752389 0.311384196288908 NA NA NA 0.30358032818298 98.1435792383088 a3673 gain_cnaBRCA31 1203 QL-XII-61 BTK 8 15 2.30258509299405 NA 3.78179830694084 4.46169782800508 -0.679899521064236 1.8927286202316 1.25339080573219 0.454128372765406 0.359216590163381 0.542448147820151 0.311392343271899 NA NA NA 0.381133990024533 98.1435792383088 a3674 loss_cnaBRCA36_(FAT1,IRF2) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 9 37 1.38629436111989 NA 2.4068975859331 2.96848505268045 -0.561587466747351 1.149677568013 1.5386535585144 0.380588323661637 0.488473883784607 0.364986298338382 0.311433797320985 NA NA NA 0.239226873320346 98.1435792383088 a3675 loss_cnaBRCA38 164 JQ12 HDAC 4 43 1.63315443905142 NA 0.777368927509136 1.65234961259116 -0.874980685082028 1.36933237428927 1.6525952451768 0.535078386336274 0.63898342105303 0.529458551714773 0.311492921410126 NA NA NA 0.298763694196499 98.1435792383088 a3676 NF1_mut 1061 SB590885 BRAF 4 38 1.6094379124341 NA 3.48401218163227 4.06748006639191 -0.583467884759641 0.647682029342892 1.11113425557107 0.538614728554032 0.900855448083993 0.525110158231747 0.311685550437526 NA NA NA 0.175021041032113 98.1690406473313 a3677 loss_cnaBRCA36_(FAT1,IRF2) 235 QL-XII-47 BTK, BMX 9 40 2.32630161961136 NA 2.1696088535814 1.60422999909945 0.565378854481956 1.42128788231377 1.5141669512027 0.377230004509472 0.397793340474806 0.373392679078668 0.31178290507453 NA NA NA 0.307062656010631 98.1690406473313 a3678 gain_cnaBRCA47_(EGFR) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 7 40 2.77258872223978 NA 4.64677576138322 5.07462348418504 -0.427847722801822 1.21832792159349 0.987049200704082 0.419081351342996 0.351176161375524 0.433461394322217 0.311828077986773 NA NA NA 0.40639647071601 98.1690406473313 a3679 loss_cnaBRCA24 172 Embelin XIAP 3 45 3.46573590279973 NA 2.44220180274332 3.02978620493349 -0.587584402190167 0.552968620385587 0.978858188613231 0.609362622893486 1.06259990264989 0.600275309565127 0.312157580434774 NA NA NA 0.195319472096005 98.1941903170225 a3680 gain_cnaBRCA63 201 Epothilone B Microtubules 6 42 -3.44201937618241 NA -3.53425755766773 -4.33597226293097 0.801714705263242 2.61792115564768 1.67064061372221 0.445905666710198 0.30624096662869 0.479884601558328 0.312267137483951 NA NA NA 0.49523702244456 98.1941903170225 a3681 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 8 35 -1.38629436111989 0.693147180559945 -2.5299651351207 -2.14977881077903 -0.380186324341663 1.00367551271402 0.936765265523271 0.400819233501748 0.378794061950968 0.405850150869219 0.312396765425128 NA NA NA 0.350987310715062 98.1941903170225 a3682 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1241 CHIR-99021 GSK3B 9 37 2.30258509299405 NA 4.52901863454683 4.15911455522913 0.369904079317694 0.573039963997219 1.04227802652769 0.379807343073471 0.645511836098554 0.354899623615799 0.312416190200265 NA NA NA 0.163044599736041 98.1941903170225 a3683 TP53_mut 305 TPCA-1 IKK 38 11 2.99573227355399 NA 4.07035417299583 4.55132121303887 -0.48096704004304 1.37751198863054 1.37070632906897 0.349523033217226 0.349156336941355 0.350889924298905 0.312547227291525 NA NA NA 0.320904552959497 98.1941903170225 a3684 gain_cnaBRCA64_(SDHC) 302 PI-103 PI3Ka, PRKDC (DNAPK) 8 40 2.32630161961136 NA 0.519998016010872 1.25012018808351 -0.73012217207264 1.45345242699068 1.90935624251028 0.395247687443477 0.502336477282805 0.382391800868302 0.312816882213454 NA NA NA 0.243315474128735 98.1941903170225 a3685 loss_cnaBRCA17 206 Ruxolitinib JAK1, JAK2, TYK2 11 38 1.65632149833295 0.0237165266173161 4.19387838944191 4.42131841790404 -0.227440028462131 0.898149690203342 0.566120417661009 0.349315025511047 0.25323176185769 0.40175203254782 0.312832160822187 NA NA NA 0.441365600399603 98.1941903170225 a3686 ASH1L_mut 303 PIK-93 PI4K, PI3K 3 46 2.99573227355399 NA 3.60002437307646 2.73879912314092 0.861225249935533 1.20391191785553 1.42561804302539 0.607827618701706 0.715355697673959 0.604106586717907 0.312926321105627 NA NA NA 0.340408568597306 98.1941903170225 a3687 gain_cnaBRCA58_(CCND1) 1067 CCT007093 PPM1D 8 38 1.88706964903238 NA 4.40771780842021 4.0178295745349 0.389888233885311 0.706108114936303 1.02577689991824 0.39707257745176 0.552165065997694 0.380090674606134 0.312943471752678 NA NA NA 0.214643001367616 98.1941903170225 a3688 BRCA1_mut 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 4 39 1.6094379124341 NA 2.21673121701345 3.02069381592787 -0.803962598914418 0.3854872624271 1.55349077942354 0.536258593075865 2.08557500409357 0.517520032666525 0.313047073911258 NA NA NA 0.0202022988975003 98.1941903170225 a3689 BRCA2_mut 221 TAK-715 p38a 6 43 2.99573227355399 2.32630161961136 4.09094670070968 4.53673959945645 -0.445792898746765 0.73932446336804 1.02998434814414 0.444426500738436 0.602973282820816 0.432815216609856 0.313047746662081 NA NA NA 0.226477285655353 98.1941903170225 a3690 gain_cnaBRCA14_(RAD21) 1031 Elesclomol HSP70 20 24 -1.6094379124341 NA -2.67787911867849 -3.22732903048095 0.549449911802465 1.85437333081486 1.71269376854948 0.308994670945174 0.296299511361621 0.320810364288186 0.31329836932171 NA NA NA 0.317234427359103 98.1941903170225 a3691 BRCA2_mut 200 LAQ824 HDAC 6 42 0.0237165266173161 NA -3.23170237630117 -2.60629098611125 -0.62541139018992 0.880421461526523 1.45683746912562 0.444917246293972 0.710354548951529 0.429293866642026 0.313329056030865 NA NA NA 0.172504439206454 98.1941903170225 a3692 loss_cnaBRCA29_(MAP2K4) 272 AR-42 HDAC 7 42 1.63315443905142 NA -0.401703752649842 0.232580682468107 -0.634284435117949 1.09890979661773 1.57734950035333 0.41601837173849 0.577194267509652 0.402120414642328 0.313404434523909 NA NA NA 0.215304644165072 98.1941903170225 a3693 MACF1_mut 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 3 40 0.693147180559945 NA 3.44937840121518 2.8678467154386 0.581531685776582 0.823651749918151 0.958026968259634 0.61090890961926 0.706040733640608 0.607009724197014 0.313453649513766 NA NA NA 0.345686440845731 98.1941903170225 a3694 loss_cnaBRCA38 221 TAK-715 p38a 4 45 2.99573227355399 2.32630161961136 3.99251879348723 4.52567572904303 -0.533156935555797 1.10866827048749 0.995491968530571 0.531510539528498 0.480898524606789 0.535571307865779 0.31355658205771 NA NA NA 0.413254036906797 98.1941903170225 a3695 POLR2B_mut 303 PIK-93 PI4K, PI3K 3 46 2.99573227355399 NA 3.59897831103036 2.73886734457871 0.86011096645165 1.39588601379606 1.41785926558566 0.60702381423086 0.616175646113547 0.606626473676408 0.313559735224049 NA NA NA 0.39861572426389 98.1941903170225 a3696 loss_cnaBRCA18 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 14 31 2.30258509299405 NA 3.47026709592178 3.04436369925583 0.425903396665958 0.979744419530974 1.41288428980748 0.32830553154868 0.434708673176059 0.301442517082551 0.313635058054843 NA NA NA 0.250610575216205 98.1941903170225 a3697 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1001 AICAR AAPK1 (AMPK) agonist 6 39 7.60090245954208 NA 7.20551528325908 7.82047837453675 -0.614963091277668 1.09167591529724 1.40852409365492 0.447103930549901 0.563320196644834 0.436601045056977 0.313642378387038 NA NA NA 0.253993250053561 98.1941903170225 a3698 gain_cnaBRCA15 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 6 8 1.38629436111989 NA 1.66363541456945 2.11329485338235 -0.449659438812906 1.00741793695928 0.591330643305382 0.567940855482367 0.446348454118382 0.760419646611629 0.313689569007944 NA NA NA 0.359902676091476 98.1941903170225 a3699 gain_cnaBRCA10_(MDM2,NUP107) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 3 42 -0.669430653942629 NA -2.10940038876061 -3.58453371175731 1.47513332299671 3.5822133115918 2.35046672570306 0.609133951318005 0.41179382540489 0.627591663760087 0.313772677574488 NA NA NA 0.551356135087435 98.1941903170225 a3700 BRCA1_mut 328 SNX-2112 HSP90 4 44 0.940007258491471 NA 1.40824096841467 0.327148955699822 1.08109201271484 0.912960717385084 2.08838950318341 0.531887411790989 1.18416049248135 0.517667806253046 0.313773645541915 NA NA NA 0.0958810291182033 98.1941903170225 a3701 loss_cnaBRCA29_(MAP2K4) 166 FTI-277 Farnesyl transferase (FNTA) 7 40 0.0237165266173161 NA 1.95612759798212 2.29483347180437 -0.338705873822253 0.777560693728102 0.817253608817598 0.417087797007859 0.435600560257606 0.414444023455942 0.314109326995836 NA NA NA 0.320497149514154 98.2087659329762 a3702 gain_cnaBRCA58_(CCND1) 281 CH5424802 ALK 10 38 1.63315443905142 NA 3.87907229690287 3.49528366003269 0.383788636870176 0.837306078281075 1.10882193080858 0.361662215451059 0.458361221571524 0.346122877088396 0.31419361432582 NA NA NA 0.245853959543824 98.2087659329762 a3703 loss_cnaBRCA38 1016 Temsirolimus MTOR 3 41 -1.6094379124341 NA -2.59759551043194 -1.68899062609212 -0.908604884339825 1.09832805057428 1.50964240757178 0.60872813520471 0.827261840271444 0.601867620956206 0.314614556664244 NA NA NA 0.284862932400533 98.2087659329762 a3704 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 224 AS605240 PI3Kgamma 6 43 2.99573227355399 2.32630161961136 3.88257446863151 3.18481706756 0.697757401071505 1.04812248263504 1.62661260549147 0.442963759212508 0.665721242156075 0.428963478283559 0.314625842467373 NA NA NA 0.192646285500863 98.2087659329762 a3705 gain_cnaBRCA48 295 NVP-BHG712 EPHB4 5 44 2.32630161961136 NA 4.41419859611504 3.826766167784 0.587432428331042 0.853969940415218 1.25363542024453 0.479650398993611 0.687884198881076 0.468583145342574 0.314672026446666 NA NA NA 0.215961555515033 98.2087659329762 a3706 gain_cnaBRCA48 274 PXD101, Belinostat HDAC 5 43 2.99573227355399 NA 1.31273457548713 0.596941575091302 0.715793000395824 1.77301035182042 1.46066873195631 0.480259524806987 0.403716199209378 0.490044720432364 0.314744307115963 NA NA NA 0.427336843731718 98.2087659329762 a3707 gain_cnaBRCA15 87 GW843682X PLK1 6 6 -1.36257783450257 NA -2.49435086325536 -1.33505361838105 -1.15929724487431 2.00598735212308 1.78164420312608 0.611077932194001 0.57791852159354 0.650689538820492 0.314761489312218 NA NA NA 0.315098861609711 98.2087659329762 a3708 loss_cnaBRCA28_(GPS2) 266 Zibotentan, ZD4054 Endothelin A Receptor 4 45 2.99573227355399 NA 5.98097935579407 5.72080027594378 0.260179079850281 0.491556591849014 0.490695075110977 0.530166115427236 0.529296288900541 0.530225578056675 0.314768951075795 NA NA NA 0.374318398475489 98.2087659329762 a3709 loss_cnaBRCA38 231 FMK RSK 4 45 2.99573227355399 2.32630161961136 5.30134766724439 5.61481921115622 -0.313471543911826 0.370532770850354 0.603477294474061 0.53008896544979 0.846002212415448 0.519442150984356 0.314838619415592 NA NA NA 0.193943949035418 98.2087659329762 a3710 loss_cnaBRCA33 261 TL-1-85 MAP3K7 (TAK1) 6 43 2.32630161961136 NA 3.55566623414034 4.09026789363606 -0.534601659495714 0.845856325668733 1.24384322739985 0.442641123448458 0.632024190483009 0.429798263735579 0.314974647243571 NA NA NA 0.210224096782475 98.2087659329762 a3711 gain_cnaBRCA64_(SDHC) 290 KIN001-260 IKK 8 41 2.99573227355399 NA 5.38513510056323 4.97752505636735 0.407610044195877 1.15123456444145 1.01727565403594 0.392565790653788 0.354063417470131 0.400687898681861 0.314988138755541 NA NA NA 0.374564000783448 98.2087659329762 a3712 gain_cnaBRCA10_(MDM2,NUP107) 190 Bleomycin DNA damage 4 44 4.15888308335967 NA 3.40763124432449 1.95755987560259 1.4500713687219 1.4953101481562 2.79990382553484 0.530410837870066 0.969746223223269 0.51790042054209 0.315104115048112 NA NA NA 0.149989173314392 98.2087659329762 a3713 gain_cnaBRCA30_(CRNKL1,FOXA2) 219 AT-7519 CDK9 5 44 2.32630161961136 NA 2.44908540922387 1.58369540042793 0.865390008795935 1.28290357132372 1.84697250467819 0.479217659529241 0.674555771875368 0.468545149753986 0.315104122281665 NA NA NA 0.223038008861576 98.2087659329762 a3714 gain_cnaBRCA9_(KRAS) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 4 44 0.246860077931526 2.32630161961136 0.535850821081605 -0.337752116131102 0.873602937212707 2.14954286304748 1.60669398615322 0.530240988650606 0.406413359896519 0.543727022532964 0.315257403179494 NA NA NA 0.480708811014266 98.2087659329762 a3715 PIK3CA_mut 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 16 30 0 NA 1.07406283978924 0.428763041758609 0.645299798030635 1.7878199968805 2.1761495721969 0.314467890432137 0.360942264409501 0.296532833163293 0.315267188671948 NA NA NA 0.287668500914861 98.2087659329762 a3716 loss_cnaBRCA24 261 TL-1-85 MAP3K7 (TAK1) 3 46 2.32630161961136 NA 3.33906817582319 4.0695285283418 -0.730460352518611 0.611496990221851 1.22756980686089 0.604799520687282 1.19454447724036 0.595045877176243 0.315317060065116 NA NA NA 0.157627714996781 98.2087659329762 a3717 gain_cnaBRCA58_(CCND1) 1203 QL-XII-61 BTK 5 18 2.30258509299405 NA 4.83477998758613 4.05588632987068 0.778893657715442 0.616770924622719 1.63755605141996 0.520040867609595 1.26285728885792 0.475643967753072 0.315317645320685 NA NA NA 0.117603545350284 98.2087659329762 a3718 loss_cnaBRCA34 190 Bleomycin DNA damage 5 43 4.15888308335967 NA 0.903976510875311 2.21495992905664 -1.31098341818133 2.13178370815809 2.78447385084089 0.479526742192971 0.614970183496735 0.470819080518722 0.315475137280853 NA NA NA 0.257903392155663 98.2087659329762 a3719 loss_cnaBRCA17 344 THZ-2-49 CDK9 11 38 2.99573227355399 NA 1.38964545366937 1.89979933639538 -0.510153882726011 1.81521602435358 1.36009095851052 0.347330595468446 0.281043069189345 0.375088062701848 0.315559352760267 NA NA NA 0.402497901164877 98.2087659329762 a3720 gain_cnaBRCA16 211 TL-2-105 CRAF 16 33 2.32630161961136 1.63315443905142 3.68185003258134 4.01698583539887 -0.335135802817528 1.05174985559425 1.09963801026673 0.308999310559729 0.318645922350208 0.304769205582696 0.3156218667828 NA NA NA 0.310770260458396 98.2087659329762 a3721 loss_cnaBRCA28_(GPS2) 294 MPS-1-IN-1 MPS1 4 45 2.99573227355399 NA 5.32433238851224 4.70604528646014 0.618287102052105 0.885286464850661 1.18520292992571 0.529191461461611 0.698403428269293 0.521671931819188 0.315649856407255 NA NA NA 0.263893783008625 98.2087659329762 a3722 loss_cnaBRCA29_(MAP2K4) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 7 41 2.07944154167984 NA 3.62429901681868 3.14430420784024 0.479994808978438 1.43081158027243 1.11012987286684 0.414858143799553 0.335470313209967 0.432377166591224 0.315686179119559 NA NA NA 0.424884909963218 98.2087659329762 a3723 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 312 AV-951 VEGFR 9 39 -2.05572501506252 NA 0.437485467421702 0.677227474800346 -0.239742007378644 0.425292463911909 0.675875634922128 0.374954381155236 0.563710923004508 0.354713197208634 0.315916051839432 NA NA NA 0.194963308175848 98.2120559619577 a3724 BRCA1_mut 222 BX-912 PDPK1 (PDK1) 4 45 2.32630161961136 NA 4.61532638769552 3.81875450361864 0.796571884076879 0.95467046617012 1.53703912291424 0.528718902766284 0.834394602435447 0.518250883924523 0.316077562287235 NA NA NA 0.198769578831799 98.2120559619577 a3725 loss_cnaBRCA17 1043 JNK Inhibitor VIII JNK 6 37 2.30258509299405 NA 5.0828787541428 4.75102616934408 0.331852584798723 0.330952066471771 0.783323813430877 0.446608153918475 1.00272099321377 0.423646746222668 0.316165293206101 NA NA NA 0.0940300446643354 98.2120559619577 a3726 gain_cnaBRCA58_(CCND1) 167 OSU-03012 PDPK1 (PDK1) 9 39 2.77258872223978 NA 2.60712040913742 2.1651002472259 0.442020161911519 0.557115307787146 1.27281848678881 0.374607505842908 0.793408753507809 0.347276667097041 0.316359056697568 NA NA NA 0.119467789176081 98.2120559619577 a3727 TP53_mut 54 CGP-082996 CDK4 9 3 1.63315443905142 NA 2.98528196827678 2.28050510436213 0.70477686391465 0.927690137469151 1.26078273951111 0.702531712005601 0.759711497890196 0.558999454725988 0.316771533010939 NA NA NA 0.443547216103311 98.2120559619577 a3728 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 258 STF-62247 stimulates autophagy 7 42 2.32630161961136 NA 4.97007708744012 4.57430387503911 0.395773212401006 1.07475075447526 0.93979193468991 0.413090006259868 0.36824650808851 0.42112854749237 0.316786112062176 NA NA NA 0.387002544642795 98.2120559619577 a3729 loss_cnaBRCA17 312 AV-951 VEGFR 10 38 -2.05572501506252 NA 0.450231496405164 0.680182256840979 -0.229950760435815 0.876837081348001 0.566825722827313 0.359624869842597 0.262250268980757 0.405681589905317 0.316897474439675 NA NA NA 0.44773735606953 98.2120559619577 a3730 POLR2B_mut 202 GSK-1904529A IGF1R 3 45 0.0237165266173161 NA 2.65901518166003 2.15838504111882 0.500630140541212 0.564857865052412 0.84005966912879 0.603173224562109 0.886294006891025 0.595945929722356 0.317043596562482 NA NA NA 0.259216610175322 98.2120559619577 a3731 gain_cnaBRCA8_(CHD4,WNK1) 1149 TW 37 BCL2, BCL2L1 3 40 1.6094379124341 NA -0.843018645494635 -0.0898366620689152 -0.75318198342572 1.10485774072462 1.24883606769511 0.606329098172971 0.681700417767579 0.603107167473003 0.317050334759044 NA NA NA 0.359388410338947 98.2120559619577 a3732 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 179 5-Fluorouracil DNA antimetabolite 15 34 3.46573590279973 NA 4.39223535252147 3.88673021843593 0.505505134085539 1.20228808301479 1.75825751617197 0.313429877041683 0.420452586386754 0.28750346831226 0.317108982434362 NA NA NA 0.249985702054799 98.2120559619577 a3733 TP53_mut 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 38 10 2.77258872223978 NA -0.331478489216522 -0.835712308361769 0.504233819145246 1.1906385421528 2.05750345577923 0.359386924515187 0.423498653280228 0.245070703394896 0.317214288362624 NA NA NA 0.473609933456775 98.2120559619577 a3734 MLL3_mut 1006 Cytarabine DNA synthesis 3 42 0.693147180559945 NA 2.06785336295446 1.1471532684968 0.920700094457662 0.817784538183489 1.54900882689278 0.604608317113798 1.12584678661543 0.594380147145147 0.317339194131072 NA NA NA 0.175994557079356 98.2120559619577 a3735 gain_cnaBRCA15 1023 GW 441756 NTRK1 21 24 0.693147180559945 NA 2.5683753948464 2.17633426243699 0.392041132409417 1.30397543002351 1.29070268754493 0.302292592032662 0.300650705053812 0.30374240031616 0.317357495004826 NA NA NA 0.317812720257128 98.2120559619577 a3736 loss_cnaBRCA18 166 FTI-277 Farnesyl transferase (FNTA) 15 32 0.0237165266173161 NA 2.06945822546572 2.326386208627 -0.256927983161274 0.513016740919618 0.915820019636016 0.316335728029158 0.500817931790516 0.280544187343041 0.317456254059485 NA NA NA 0.225971330261672 98.2120559619577 a3737 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1042 BIRB 0796 p38, JNK2 4 39 2.30258509299405 NA 4.81007108389486 4.32111088493829 0.488960198956565 0.412347970659883 0.948844767723729 0.531330474333399 1.18579508994328 0.515321594837453 0.317459804567666 NA NA NA 0.0979914438917372 98.2120559619577 a3738 gain_cnaBRCA10_(MDM2,NUP107) 271 VNLG/124 HDAC, RAR 5 44 1.63315443905142 NA 4.49848564642224 4.11200311235891 0.386482534063327 0.335841552461002 0.841125719301481 0.476855757693561 1.15078831440372 0.459482483051742 0.317469600959535 NA NA NA 0.0745387618938523 98.2120559619577 a3739 gain_cnaBRCA47_(EGFR) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 7 38 2.30258509299405 NA 1.75107431093715 1.29426475035068 0.456809560586463 0.694851254842589 1.15041231734438 0.415943457588747 0.657420645645878 0.397083335860802 0.317542142609984 NA NA NA 0.179667017181122 98.2120559619577 a3740 loss_cnaBRCA18 1052 RO-3306 CDK1 12 31 1.6094379124341 NA 3.82230490729348 3.41084824582366 0.411456661469825 1.03733442669711 1.24994379640666 0.343850235883367 0.396648034501188 0.329180130060791 0.317774860959259 NA NA NA 0.282481486142379 98.2120559619577 a3741 gain_cnaBRCA63 166 FTI-277 Farnesyl transferase (FNTA) 6 41 0.0237165266173161 NA 2.55711936059531 2.19862233888971 0.358497021705602 1.28454322439785 0.732057900608904 0.441378856645489 0.279085214803615 0.489711293884562 0.317995964820623 NA NA NA 0.531258622997451 98.2120559619577 a3742 gain_cnaBRCA15 1006 Cytarabine DNA synthesis 21 24 0.693147180559945 NA 1.45370745115726 0.994005870476102 0.459701580681157 1.61143030146132 1.44141589695933 0.301868207018663 0.285275497341882 0.318923623397589 0.318029463987896 NA NA NA 0.321992847015138 98.2120559619577 a3743 gain_cnaBRCA64_(SDHC) 219 AT-7519 CDK9 8 41 2.32630161961136 NA 1.08258205924279 1.78700898026844 -0.704426921025648 2.13796149039298 1.74150954908591 0.390030976188827 0.329485317762279 0.404492138096739 0.318089570720639 NA NA NA 0.403585828408203 98.2120559619577 a3744 gain_cnaBRCA48 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 5 41 1.63315443905142 NA 1.26018172797972 2.01908439404729 -0.758902666067569 0.759640530250964 1.64653076517019 0.478342605049589 0.999028666646905 0.460910103911192 0.318110325860433 NA NA NA 0.1065413832605 98.2120559619577 a3745 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 301 PHA-793887 CDK-pan 5 43 2.32630161961136 NA 2.22326723607991 3.00354928638691 -0.780282050306999 1.09616633780109 1.67857077501108 0.476893310670368 0.7118281445061 0.464849062025311 0.318111049287435 NA NA NA 0.204748768880343 98.2120559619577 a3746 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1004 Vinblastine Microtubules 8 37 -2.30258509299405 NA -3.04151950840411 -3.5450827010008 0.503563192596698 1.71489261638438 1.17515307468773 0.393827530039936 0.293641238982295 0.428508594704149 0.318118362678584 NA NA NA 0.450319145236135 98.2120559619577 a3747 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 192 LFM-A13 BTK 9 39 2.77258872223978 NA 5.04834540344799 4.73711429060371 0.311231112844284 0.489409221780395 0.889630296149376 0.373205659025689 0.635932260761399 0.349843203622222 0.318153685343722 NA NA NA 0.164692295809447 98.2120559619577 a3748 gain_cnaBRCA9_(KRAS) 1030 KU-55933 ATM 4 38 2.30258509299405 NA 4.6638401596593 4.17582137561511 0.488018784044198 0.367844441373712 0.949440011003969 0.531216159803575 1.32669881382928 0.514006970833419 0.318294296337269 NA NA NA 0.0748668084067333 98.2120559619577 a3749 loss_cnaBRCA17 104 Bortezomib Proteasome 4 10 -3.91202300542815 NA -3.80542045898424 -4.8784320955728 1.07301163658855 1.76526645704399 1.73425950894506 0.615943077160416 0.607846839386139 0.618714575906384 0.318336009976095 NA NA NA 0.345112255454816 98.2120559619577 a3750 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1072 BMS-708163 g-secretase 7 39 1.6094379124341 NA 3.35005961609285 3.74423261685364 -0.394173000760785 0.927195498682695 0.955342669672005 0.414241577114971 0.425123936991501 0.412598550524405 0.318419880178351 NA NA NA 0.33119729575249 98.2120559619577 a3751 gain_cnaBRCA47_(EGFR) 1009 ATRA Retinoic acid and retinoid X receptor agonist 7 38 2.30258509299405 NA 4.51022381517389 4.03150322408275 0.478720591091145 1.06407920516888 1.16698420484475 0.415132011322332 0.449891877188942 0.410220283276953 0.318476185916068 NA NA NA 0.309876683323364 98.2120559619577 a3752 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1050 ZM-447439 AURKB 6 33 1.38629436111989 0.693147180559945 3.38590152523166 2.79738272816406 0.5885187970676 1.36086187066731 1.3035733339333 0.448750418847173 0.432460347190868 0.451465814578953 0.31852316584538 NA NA NA 0.360458916422137 98.2120559619577 a3753 BRCA1_mut 1059 AZD8055 MTORC1/2 4 39 0.693147180559945 NA 0.61301940101473 0.0809344600733339 0.532084940941396 0.571498556044443 1.03032402717404 0.530024432221406 0.93103461997202 0.516424859469494 0.318636314270715 NA NA NA 0.164580391828216 98.2120559619577 a3754 loss_cnaBRCA22_(SYNCRIP,ZNF292) 51 Dasatinib ABL, SRC, KIT, PDGFR 3 9 0.246860077931526 NA 1.38027439796478 2.16038925330606 -0.780114855341273 1.78913327511763 0.868238071587167 0.699642070231884 0.436029482090976 0.898503395405362 0.318665989374079 NA NA NA 0.533378735220574 98.2120559619577 a3755 PIK3CA_mut 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 15 28 1.6094379124341 NA 3.16698237936106 2.70776783490584 0.459214544455222 1.42085982656213 1.42231646621466 0.322976739918552 0.323194826027509 0.322863831899079 0.318704888764256 NA NA NA 0.321049213051749 98.2120559619577 a3756 loss_cnaBRCA34 1052 RO-3306 CDK1 5 38 1.6094379124341 NA 3.01786078987217 3.59249080417617 -0.574630014304002 1.06471022083788 1.21007743593087 0.480189719261972 0.539705549038302 0.474870448156037 0.318711750467362 NA NA NA 0.311237937961837 98.2120559619577 a3757 TP53_mut 133 Doxorubicin DNA intercalating 38 10 0.0237165266173161 NA -0.894135069378692 -1.5493826573239 0.655247587945203 1.69664055488429 2.29412531747962 0.358261762030328 0.386202950329625 0.285619788488744 0.318715298349862 NA NA NA 0.415311149636006 98.2120559619577 a3758 gain_cnaBRCA31 53 CGP-60474 CDK1,CDK2,CDK5,CDK7,CDK9 3 9 -1.36257783450257 NA -0.923758671890548 -1.95903673207711 1.03527806018656 1.68290844402588 1.42476026909568 0.699513859368322 0.615171944654314 0.726633162534547 0.318750242944155 NA NA NA 0.40848551041696 98.2120559619577 a3759 gain_cnaBRCA31 153 Midostaurin KIT 16 31 -0.669430653942629 NA 0.909031858184898 0.458972300093277 0.450059558091621 1.53734052507327 1.40515273685976 0.310267270200097 0.292752029073176 0.320292268794506 0.318880044338917 NA NA NA 0.336008282526436 98.2259120351242 a3760 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1039 SL 0101-1 RSK, AURKB, PIM3 16 27 2.30258509299405 NA 4.84071223988986 4.53511939279491 0.30559284709495 0.870817851421782 1.00884631164505 0.318110017844345 0.350926254665093 0.302913182679572 0.319229600267549 NA NA NA 0.301910901278709 98.2735562095393 a3761 loss_cnaBRCA34 194 AUY922 HSP90 5 42 -1.36257783450257 NA -3.12675646977454 -2.30648405160318 -0.820272418171363 1.08115335814029 1.77180267552667 0.47644068882193 0.758701262864617 0.462959238916116 0.319274899640362 NA NA NA 0.183873286317062 98.2735562095393 a3762 gain_cnaBRCA10_(MDM2,NUP107) 326 GSK690693 AKT 5 43 2.32630161961136 NA 3.75923584985114 2.8442692273301 0.914966622521047 2.04760243018421 1.91106921804729 0.475720912717866 0.446847790876441 0.478772099869804 0.319289332809644 NA NA NA 0.386064599083273 98.2735562095393 a3763 gain_cnaBRCA30_(CRNKL1,FOXA2) 158 PF-562271 FAK 5 40 0.940007258491471 NA 2.87853742502801 2.26508930311944 0.613448121908569 1.36032702895806 1.27624150914753 0.477653341396437 0.450956357441812 0.480667740009744 0.319576743438299 NA NA NA 0.38313018161876 98.3011849991649 a3764 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1143 HG-5-88-01 EGFR, ADCK4 5 21 2.30258509299405 NA 4.13707015129861 4.62860249878887 -0.491532347490269 0.90542962035789 0.984639567200935 0.505750862363667 0.542871954306046 0.499200279842057 0.319598347423056 NA NA NA 0.321966277664715 98.3011849991649 a3765 gain_cnaBRCA62 1259 BMN-673 PARP1 8 38 2.30258509299405 NA 3.80735418495956 3.19989253639913 0.607461648560424 0.722283412693161 1.66254591611264 0.391518283394857 0.841029487712304 0.365380373963318 0.319682623529261 NA NA NA 0.114293174289571 98.3011849991649 a3766 BRCA2_mut 1072 BMS-708163 g-secretase 5 41 1.6094379124341 NA 3.27995109638623 3.73355448507343 -0.4536033886872 0.73752438539107 0.970429678227135 0.476666974136837 0.615035106190663 0.467425305371824 0.319789321854123 NA NA NA 0.259164391337528 98.3011849991649 a3767 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 14 34 2.32630161961136 NA 4.80159217006129 5.02309555841314 -0.22150338835185 0.778733238998821 0.65697005006649 0.319375401723866 0.284440649581912 0.337159035376777 0.319803578799425 NA NA NA 0.359933451297396 98.3011849991649 a3768 BRCA2_mut 273 CUDC-101 HDAC, EGFR 6 43 1.63315443905142 NA 0.57425815583547 -0.110495953219847 0.684754109055317 1.6131181718516 1.55758815285528 0.437937308358672 0.424490977167115 0.439624625932127 0.320089774457955 NA NA NA 0.363678915369806 98.3495828927429 a3769 gain_cnaBRCA15 1030 KU-55933 ATM 20 22 2.30258509299405 NA 4.37194570852937 4.08625721551927 0.285688493010103 0.918493658692889 0.919030740908401 0.310944775293231 0.311040245412981 0.310858473273396 0.320256920202492 NA NA NA 0.320300024344692 98.3495828927429 a3770 loss_cnaBRCA33 1022 AZD7762 CHEK1, CHEK2 5 40 0.693147180559945 NA 0.219246837875096 0.990438666586332 -0.771191828711236 1.27448921276182 1.64810104161498 0.476929852471679 0.605098749357058 0.467927517329608 0.320301837225849 NA NA NA 0.265894275482083 98.3495828927429 a3771 loss_cnaBRCA24 206 Ruxolitinib JAK1, JAK2, TYK2 3 46 1.65632149833295 0.0237165266173161 4.73619314866229 4.34639527648321 0.389797872179079 0.331527377004001 0.661958111511506 0.59847260252043 1.17576375049827 0.588855798275543 0.320352158744223 NA NA NA 0.16244643017732 98.3495828927429 a3772 gain_cnaBRCA31 179 5-Fluorouracil DNA antimetabolite 16 33 3.46573590279973 NA 4.37383176103167 3.880334834489 0.493496926542666 1.48920368908583 1.6679415365386 0.305940107273354 0.331383094307001 0.295871837070978 0.320385721281135 NA NA NA 0.303492208525477 98.3495828927429 a3773 TP53_mut 1371 PLX4720 (rescreen) BRAF 37 10 2.30258509299405 NA 4.77971110916707 4.43866141183947 0.3410496973276 0.649261964936347 1.69021700950611 0.357792638548366 0.525288274604283 0.201778644641173 0.320802544934328 NA NA NA 0.545893824796154 98.4068314840912 a3774 gain_cnaBRCA47_(EGFR) 341 EX-527 SIRT1 7 42 2.99573227355399 NA 5.41266557929743 5.67993451537465 -0.267268936077221 0.738781129129635 0.638858785048666 0.40962799476769 0.361770117750697 0.418353699334135 0.320815805478915 NA NA NA 0.394564345140133 98.4068314840912 a3775 ARID1A_mut 226 GSK1070916 AURKB 5 44 0.940007258491471 2.32630161961136 3.22941383243907 2.31014474066041 0.919269091778669 0.568052511507614 2.02253304710953 0.473450005563483 1.61828188971285 0.454513755951936 0.320901615446044 NA NA NA 0.0312884837478796 98.4068314840912 a3776 loss_cnaBRCA33 172 Embelin XIAP 6 42 3.46573590279973 NA 3.36267082176916 2.9402609452291 0.422409876540065 0.637791803305976 0.997204838289033 0.437890661614582 0.662300572617138 0.423593889962287 0.320948843410776 NA NA NA 0.196114729501482 98.4068314840912 a3777 PIK3CA_mut 64 CMK RSK 4 8 1.38629436111989 NA 2.70828298920854 1.95209321929526 0.756189769913288 1.20884088894285 1.17227529604218 0.639017255396467 0.625549463812882 0.645061593011747 0.321281497756279 NA NA NA 0.342435268313783 98.4068314840912 a3778 BRCA1_mut 1133 JNJ-26854165 MDM2 4 39 2.30258509299405 NA 2.55331110745671 3.01143164478516 -0.458120537328454 0.230183531178416 0.900480494433047 0.527094240360144 1.99024028775266 0.508751205784742 0.321286651590787 NA NA NA 0.0240485198526963 98.4068314840912 a3779 gain_cnaBRCA14_(RAD21) 1248 FK866 NAMPT 20 24 0 NA -0.202591620608104 -1.02413441183111 0.82154279122301 2.65105265465269 2.7473901351824 0.303798702517024 0.309893049382167 0.299026621921122 0.321407330435413 NA NA NA 0.319950568319156 98.4068314840912 a3780 BRCA2_mut 1049 PD-173074 FGFR1, FGFR3 5 38 0.693147180559945 NA 2.45736505611527 3.00097437592342 -0.543609319808151 1.28572804711898 1.12150515059999 0.477449142487204 0.422802723349044 0.484714064413638 0.321448092906031 NA NA NA 0.410034838500107 98.4068314840912 a3781 loss_cnaBRCA33 1019 Bosutinib SRC, ABL, TEC 5 40 0.693147180559945 NA 2.26892576202684 2.71180763422037 -0.442881872193534 0.783475394654968 0.944664374064139 0.475783098932548 0.5652785974071 0.468824573417716 0.321453413839583 NA NA NA 0.292335220466243 98.4068314840912 a3782 gain_cnaBRCA58_(CCND1) 184 BMS-754807 IGF1R 9 39 0.940007258491471 NA 2.13062815145768 1.51061683234654 0.620011319111142 0.83885879924885 1.80019887270759 0.370561181062413 0.73911285149101 0.344412680460473 0.321557838237769 NA NA NA 0.134054250056244 98.4068314840912 a3783 POLR2B_mut 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 3 45 2.07944154167984 NA 2.56637577457971 3.25749862923204 -0.691122854652328 0.576069797936665 1.17695030170994 0.597169814481919 1.1997206885828 0.587214985754477 0.321832036530866 NA NA NA 0.156083037501092 98.4068314840912 a3784 gain_cnaBRCA9_(KRAS) 1021 Axitinib PDGFR, KIT, VEGFR 4 41 0.693147180559945 NA 3.02021107554819 2.40792657136187 0.61228450418632 1.13241261433208 1.1688491913806 0.524960459335132 0.540690289420218 0.523835331967091 0.321867008862278 NA NA NA 0.366635218471774 98.4068314840912 a3785 gain_cnaBRCA8_(CHD4,WNK1) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 4 45 3.68887945411394 NA 2.88797846073914 3.51025685293975 -0.622278392200614 0.193518163191836 1.23035079898863 0.522290815256135 3.21560716543049 0.505773144303348 0.321934522509659 NA NA NA 0.00504158546268225 98.4068314840912 a3786 ARID1A_mut 1066 AZD6482 PI3Kbeta 5 38 1.6094379124341 NA 1.36313396879366 2.04666838392505 -0.683534415131387 1.43714281976359 1.43279987143825 0.476920803828185 0.475620380752295 0.477062029915772 0.321977439022795 NA NA NA 0.362265935224437 98.4068314840912 a3787 gain_cnaBRCA16 190 Bleomycin DNA damage 16 32 4.15888308335967 NA 2.63718663121225 1.799005418888 0.838181212324244 2.64655423927181 2.77638103818873 0.306495779469113 0.316706606608171 0.301897038192949 0.322058288476061 NA NA NA 0.316702600149327 98.4068314840912 a3788 loss_cnaBRCA7_(FAS,PTEN) 193 GW-2580 CSF1R (cFMS) 4 44 2.99573227355399 NA 5.81961026750151 5.43100510389392 0.388605163607586 0.251517716761179 0.765993840637159 0.522757997725964 1.54504091644794 0.507321525306707 0.322060999356952 NA NA NA 0.046836898960272 98.4068314840912 a3789 loss_cnaBRCA23 1371 PLX4720 (rescreen) BRAF 3 44 2.30258509299405 NA 5.24027009698674 4.67079806515037 0.569472031836377 0.410267172008574 0.971156324470117 0.597393156411632 1.38805166654786 0.586385546268355 0.322108523792161 NA NA NA 0.114097151747984 98.4068314840912 a3790 NF1_mut 1264 SGC0946 Q8TEK3 (DOT1L) 5 41 -0.693147180559945 NA 1.6949788651122 1.98190083383439 -0.286921968722191 0.748790430931627 0.588596645645144 0.474317621882132 0.383180602835975 0.487467896470433 0.322153471409291 NA NA NA 0.44918431272037 98.4068314840912 a3791 gain_cnaBRCA27_(CLTC,PPM1D) 29 AZ628 BRAF 3 11 1.38629436111989 NA 3.55712236321498 2.19398717316996 1.36313519004503 1.22365914321589 2.15185539327259 0.672524788168656 1.11398276031557 0.633469699825853 0.32218697483046 NA NA NA 0.205510706794875 98.4068314840912 a3792 loss_cnaBRCA57 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 5 44 3.68887945411394 NA 3.96452479561221 3.40206473289055 0.562460062721659 1.6369924990007 1.14120527071866 0.472076720831009 0.343593549185481 0.492864936005296 0.322292543105661 NA NA NA 0.492085594679359 98.4074021052624 a3793 ASH1L_mut 345 KIN001-270 CDK9 3 46 2.99573227355399 NA 4.72259741473135 5.13269500383613 -0.410097589104785 0.453042762086356 0.696755906217941 0.595945879037265 0.90520724184225 0.588581432098415 0.322378059418597 NA NA NA 0.251487333926997 98.4074021052624 a3794 loss_cnaBRCA29_(MAP2K4) 290 KIN001-260 IKK 7 42 2.99573227355399 NA 4.68064154491922 5.10464565002697 -0.424004105107747 0.652583059270417 1.08368919649196 0.408219918257546 0.649732013549019 0.391259880120887 0.322464619215951 NA NA NA 0.179443309211807 98.4074021052624 a3795 loss_cnaBRCA7_(FAS,PTEN) 1161 ZG-10 IRAK1 3 23 2.30258509299405 NA 2.73949008669254 1.87574805468554 0.863742032007001 2.05094006371832 1.31703042193205 0.620042544700893 0.421144453359134 0.655825421815175 0.322528794360023 NA NA NA 0.544575038793555 98.4074021052624 a3796 loss_cnaBRCA17 1371 PLX4720 (rescreen) BRAF 9 38 2.30258509299405 NA 4.99274641925056 4.63950545748214 0.353240961768417 0.540149579499367 1.02087127208933 0.370547498500465 0.65396878045488 0.346019102923201 0.322869234805141 NA NA NA 0.161884690035779 98.4262802486318 a3797 BRCA2_mut 1371 PLX4720 (rescreen) BRAF 5 42 2.30258509299405 NA 4.30432179811092 4.75510276588147 -0.450780967770554 0.293589270234793 0.994496352423697 0.472866122905484 1.53541363214688 0.453275637132255 0.322879252475949 NA NA NA 0.0378858965503429 98.4262802486318 a3798 loss_cnaBRCA60 133 Doxorubicin DNA intercalating 3 45 0.0237165266173161 NA -2.05245208767951 -0.962524509924239 -1.08992757775527 0.982930075214701 1.85864395788656 0.595814316696006 1.10885566047738 0.586410093837776 0.32291992263216 NA NA NA 0.181053904629305 98.4262802486318 a3799 loss_cnaBRCA38 295 NVP-BHG712 EPHB4 4 45 2.32630161961136 NA 3.30042800715192 3.93882205187696 -0.63839404472504 0.93065280441421 1.24270420020864 0.521068653114656 0.685963703861474 0.513713597023218 0.323056318567111 NA NA NA 0.271141153176751 98.4262802486318 a3800 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1199 Tamoxifen ER 6 41 1.6094379124341 NA 4.23111030962211 3.81620338024522 0.414906929376885 0.747884347384379 0.97233535060864 0.436735552934029 0.554774185110256 0.426711760625766 0.32305750620302 NA NA NA 0.259589514087416 98.4262802486318 a3801 gain_cnaBRCA13_(FGFR1,WHSC1L1) 231 FMK RSK 11 38 2.99573227355399 2.32630161961136 5.74608436844548 5.54382439784493 0.202259970600551 0.812695087741747 0.515785294453571 0.341902446631747 0.248875591413472 0.392139855043419 0.323101358734917 NA NA NA 0.449349976447373 98.4262802486318 a3802 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1005 Cisplatin DNA crosslinker 5 40 1.79175946922805 2.30258509299405 4.16668345317558 3.60800856388747 0.558674889288106 0.515272675381236 1.22654825530818 0.474002928335174 1.08423154570492 0.455485454298522 0.32324660976411 NA NA NA 0.0903359417903094 98.4262802486318 a3803 BRCA2_mut 271 VNLG/124 HDAC, RAR 6 43 1.63315443905142 NA 4.46088646329191 4.10826154409656 0.352624919195353 0.441994833912697 0.843920297808696 0.434968878147806 0.797803259539916 0.417841495353259 0.323346471840209 NA NA NA 0.139813230827937 98.4262802486318 a3804 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 193 GW-2580 CSF1R (cFMS) 5 43 2.99573227355399 NA 5.14943454304171 5.4998951843286 -0.350460641286894 1.18189516013107 0.687229700751886 0.471412219232061 0.29652430529289 0.509961430513642 0.323644971089591 NA NA NA 0.548421377022394 98.4262802486318 a3805 gain_cnaBRCA30_(CRNKL1,FOXA2) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 5 42 2.99573227355399 NA 4.44795086895919 3.77619944210681 0.671751426852379 1.50949124096819 1.41428149661966 0.472066209560201 0.445018433112284 0.474977172831551 0.323689572748476 NA NA NA 0.388252616640903 98.4262802486318 a3806 gain_cnaBRCA9_(KRAS) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 4 43 2.99573227355399 NA 4.5267460942313 3.78449177991527 0.742254314316032 1.6086778421808 1.40880405403084 0.521611333652983 0.461406438786895 0.526868383287451 0.32369102685975 NA NA NA 0.43054821942957 98.4262802486318 a3807 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 301 PHA-793887 CDK-pan 9 39 2.32630161961136 NA 3.41279303826936 2.80907226027212 0.603720777997243 0.771410682385142 1.76550846795444 0.368889854198892 0.782619157062468 0.341952921186908 0.323721908217938 NA NA NA 0.124698456996077 98.4262802486318 a3808 gain_cnaBRCA15 1377 Afatinib (rescreen) ERBB2, EGFR 22 25 2.30258509299405 NA 2.5272210231672 3.10516894401794 -0.577947920850747 2.37772416669475 1.55457527108681 0.291638488148806 0.243067690082045 0.37177223361253 0.323784766414416 NA NA NA 0.337717550981504 98.4262802486318 a3809 gain_cnaBRCA14_(RAD21) 1378 Bleomycin (50 uM) DNA damage 22 26 3.91202300542815 NA 4.10691847662505 3.56377842101691 0.543140055608132 1.8534296038907 1.90221193924833 0.288889107404957 0.293045958944423 0.285530778354149 0.323855383720861 NA NA NA 0.322906011423861 98.4262802486318 a3810 gain_cnaBRCA15 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 22 26 0.246860077931526 2.32630161961136 -0.522858731339612 -0.0467229898450235 -0.476135741494589 1.50054022818386 1.76269504867605 0.288882864487652 0.31730954795585 0.270118045575842 0.323865729119343 NA NA NA 0.317360709516283 98.4262802486318 a3811 gain_cnaBRCA15 1218 JQ1 BRD2, BRD3, BRD4 21 25 0 NA 2.57024252906931 2.36368292007524 0.206559608994072 0.664826762956514 0.727606838730671 0.295182560271059 0.310696892037698 0.283889042816614 0.324110043669473 NA NA NA 0.320323766928432 98.4410991226707 a3812 gain_cnaBRCA30_(CRNKL1,FOXA2) 151 QS11 ARFGAP 5 43 2.32630161961136 NA 4.38308952178256 3.68804993589199 0.695039585890568 0.938287578238641 1.51750236287462 0.470834829161475 0.740753263722515 0.458015488406849 0.324231676708566 NA NA NA 0.191808177811991 98.4410991226707 a3813 gain_cnaBRCA9_(KRAS) 1059 AZD8055 MTORC1/2 4 39 0.693147180559945 NA 0.607470881750102 0.08150353897227 0.525967342777832 0.46443887800493 1.03486297993773 0.523781708836586 1.13247914351444 0.508248292744495 0.324300742888867 NA NA NA 0.109680478395493 98.4410991226707 a3814 POLR2B_mut 192 LFM-A13 BTK 3 45 2.77258872223978 NA 5.26001930399592 4.76450017894641 0.495519125049509 0.404232923960147 0.848553660975495 0.594025681581422 1.22582574470941 0.583957323900838 0.324359219219801 NA NA NA 0.149478700045904 98.4410991226707 a3815 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 312 AV-951 VEGFR 7 41 -2.05572501506252 NA 0.85484710855558 0.594275877173653 0.260571231381928 0.830613315605835 0.605815628457887 0.407375973356869 0.313709431917633 0.430116390435842 0.324398621967603 NA NA NA 0.452426850281246 98.4410991226707 a3816 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1004 Vinblastine Microtubules 5 40 -2.30258509299405 NA -2.91798673232553 -3.52275705856587 0.604770326240345 1.43860312751095 1.26151673970575 0.472837127818921 0.420387189958852 0.479399366814116 0.324424591287772 NA NA NA 0.412020369758436 98.4410991226707 a3817 ARID1A_mut 208 SB-715992 KIF11 5 44 -2.05572501506252 NA -0.521408970469336 -1.32154591005541 0.800136939586077 1.26782928511129 1.7378078212473 0.469876354521922 0.631107791074443 0.460428897719994 0.324529630793012 NA NA NA 0.248488747733724 98.4471730404057 a3818 loss_cnaBRCA38 1020 Lenalidomide TNFA 3 42 1.6094379124341 NA 3.86140495711948 4.28282097829591 -0.421416021176424 0.82207312358447 0.70189564631629 0.595272652473783 0.512625956361316 0.600396972666965 0.324782971029498 NA NA NA 0.470244134783199 98.464330555189 a3819 PTEN_mut 253 XMD14-99 EPHB3, CAMK1 9 39 2.32630161961136 NA 4.70262245076575 4.98628939163618 -0.283666940870429 0.684925440952475 0.787582223234099 0.368058422801149 0.414157401535493 0.360174382435384 0.324802105982347 NA NA NA 0.296006844245734 98.464330555189 a3820 gain_cnaBRCA64_(SDHC) 1129 PF-4708671 RPS6KB1 (p70S6KA) 8 35 2.30258509299405 NA 4.17149800512964 3.72610267608174 0.445395329047905 1.36515694932742 1.08905099013373 0.390378851080752 0.32625943065912 0.408975643090147 0.325013358712479 NA NA NA 0.410607048097025 98.464330555189 a3821 BRCA1_mut 1170 CCT018159 HSP90 4 39 2.30258509299405 NA 3.90571412945608 3.28509654162084 0.620617587835241 1.15142777388039 1.18988564302919 0.522795317444232 0.538998278410221 0.521577507444567 0.325201943677055 NA NA NA 0.368461884285715 98.464330555189 a3822 loss_cnaBRCA34 1026 17-AAG HSP90 5 38 0 NA -1.6414482402527 -0.798148546274949 -0.843299693977756 1.57818639562156 1.8007052863701 0.47370507259626 0.534347334584409 0.468316331584552 0.325212019077887 NA NA NA 0.315766518861459 98.464330555189 a3823 gain_cnaBRCA31 1052 RO-3306 CDK1 13 30 1.6094379124341 NA 3.24959613343083 3.64530682578182 -0.395710692350987 1.40000479889911 1.10221905473286 0.330566493182782 0.282649525674592 0.359012748556497 0.325315170012017 NA NA NA 0.377043440645364 98.464330555189 a3824 PTEN_mut 1268 XAV 939 TNKS1 (tankyrase-1) 8 39 1.6094379124341 NA 3.36167617507819 3.7229332520629 -0.361257076984716 0.606171922701786 0.985145773493831 0.385825077313677 0.59596471472078 0.366704183994531 0.325502206397407 NA NA NA 0.193701003568171 98.464330555189 a3825 gain_cnaBRCA8_(CHD4,WNK1) 1013 Nilotinib ABL 3 37 0.693147180559945 NA 2.67522132210215 3.24569273864638 -0.570471416544229 0.936327076184555 0.955074645068296 0.597917557436519 0.609265107305074 0.597305581809718 0.325535672465901 NA NA NA 0.403607295143293 98.464330555189 a3826 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1230 IOX2 EGLN1 15 32 -2.30258509299405 NA 0.387486995350379 0.184763829633768 0.202723165716611 0.474878206960235 0.71750298413632 0.311034245036512 0.426895070663005 0.282539822410125 0.325545099390934 NA NA NA 0.257403433836871 98.464330555189 a3827 gain_cnaBRCA14_(RAD21) 1008 Methotrexate Dihydrofolate reductase (DHFR) 20 25 -1.6094379124341 NA 0.502747618474199 0.826572039227992 -0.323824420753793 1.29024731317996 0.891802641614544 0.29817062650877 0.250978566237577 0.363112201784391 0.32583083448064 NA NA NA 0.346768685617751 98.464330555189 a3828 gain_cnaBRCA8_(CHD4,WNK1) 1219 PFI-1 BRD2, BRD3, BRD4 3 44 2.30258509299405 NA 2.62051842396131 3.21011487869668 -0.589596454735374 0.631030711091499 1.00854844095299 0.592668461617027 0.934338764139615 0.584599044323797 0.325908808987037 NA NA NA 0.239953274229886 98.464330555189 a3829 gain_cnaBRCA31 1262 UNC1215 LMBL3 14 32 0 NA 2.8886346125819 2.70015780239865 0.188476810183249 0.661801631517678 0.5602986250784 0.318318155438822 0.284793510936237 0.336386351397662 0.325949885691062 NA NA NA 0.362804390944675 98.464330555189 a3830 gain_cnaBRCA27_(CLTC,PPM1D) 88 MS-275 HDAC 3 11 1.6094379124341 NA 0.219779183652071 1.38991592411045 -1.17013674045838 0.326349688690314 1.91623652024472 0.66699427752746 3.5855304325685 0.610643168573438 0.326019445254973 NA NA NA 0.0790641015545113 98.464330555189 a3831 gain_cnaBRCA64_(SDHC) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 8 40 2.77258872223978 NA 0.0131988925103653 -0.526472420348211 0.539671312858577 1.01668611452826 1.46223807114526 0.384493480146319 0.530814088189826 0.369072125468524 0.326021606819042 NA NA NA 0.227952298556842 98.464330555189 a3832 gain_cnaBRCA15 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 20 23 1.6094379124341 NA 3.18978240222408 2.73384068020692 0.455941722017152 1.23728502831161 1.69473681810851 0.303922383490584 0.368501769264375 0.269033939161141 0.326030197228006 NA NA NA 0.315791379533132 98.464330555189 a3833 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1166 QL-VIII-58 MTOR, ATR 5 21 2.30258509299405 NA -1.96840429087512 -1.41203249794129 -0.556371792933828 0.657974795387741 1.18560486861559 0.49892544166299 0.845582227212762 0.469272527181414 0.32603861677185 NA NA NA 0.182771379815507 98.464330555189 a3834 gain_cnaBRCA47_(EGFR) 136 Mitomycin C DNA crosslinker 7 41 2.77258872223978 NA -0.645303579580922 -0.047061674569324 -0.598241905011598 0.978015555720803 1.53477780026104 0.405826945938375 0.611689560060923 0.389790564412547 0.326222372198863 NA NA NA 0.199908614356865 98.464330555189 a3835 gain_cnaBRCA64_(SDHC) 1028 VX-702 p38 9 36 0.693147180559945 NA 3.62862331402238 3.37638346125046 0.252239852771918 0.90026141643769 0.62084335990736 0.370093239080611 0.280185119751133 0.406285818712077 0.326234184938656 NA NA NA 0.445301726331442 98.464330555189 a3836 gain_cnaBRCA10_(MDM2,NUP107) 255 CP724714 ERBB2 5 43 2.32630161961136 NA 4.50165674951578 3.72180067774329 0.779856071772492 0.811023628100035 1.72286468761165 0.468794449000491 0.961570100737313 0.452650795724174 0.326310703754234 NA NA NA 0.115389390015211 98.464330555189 a3837 PTEN_mut 261 TL-1-85 MAP3K7 (TAK1) 9 40 2.32630161961136 NA 3.66385295730913 4.10602100538526 -0.442168048076132 1.43233091825488 1.15706658906192 0.365925161561162 0.308705231759474 0.382145722861652 0.326350344879582 NA NA NA 0.40651653259039 98.464330555189 a3838 loss_cnaBRCA22_(SYNCRIP,ZNF292) 219 AT-7519 CDK9 19 30 2.32630161961136 NA 1.35038214319406 1.87569213147538 -0.525309988281313 1.97014738656326 1.6974149009405 0.290750740695348 0.266634867961665 0.309476479787145 0.326444350043361 NA NA NA 0.34450894713662 98.464330555189 a3839 gain_cnaBRCA64_(SDHC) 1072 BMS-708163 g-secretase 9 37 1.6094379124341 NA 3.96664504174632 3.61555902687095 0.351086014875372 1.27389418687951 0.864216392935885 0.368823004937047 0.275600609918301 0.406247807545833 0.326457004060256 NA NA NA 0.451412249180949 98.464330555189 a3840 gain_cnaBRCA16 55 A-770041 SRC family 3 9 1.63315443905142 NA 2.09964746932715 2.90670267015261 -0.80705520082546 1.43009659166936 1.10035818514908 0.687592780423139 0.564336147311125 0.733447718859035 0.326657892398877 NA NA NA 0.440881223957772 98.4808158074361 a3841 BRCA2_mut 203 BMS-345541 IKBKB 6 43 2.77258872223978 NA 3.15128986836365 3.58550083526166 -0.434210966898004 1.0263513234828 1.00269185698901 0.431949585230223 0.423062704712613 0.433045270958815 0.326681763119753 NA NA NA 0.365618021019163 98.4808158074361 a3842 gain_cnaBRCA62 262 VX-11e ERK 10 39 1.63315443905142 NA 3.40596305173411 3.87190140431352 -0.465938352579415 2.27685386828384 0.974333327625576 0.351191029208201 0.204641307494456 0.47821247551379 0.326866094136138 NA NA NA 0.541477683688395 98.5107366996966 a3843 loss_cnaBRCA23 258 STF-62247 stimulates autophagy 3 46 2.32630161961136 NA 4.09976007415088 4.66547874220154 -0.565718668050666 1.08941962752335 0.952271170002888 0.590208100995775 0.519284446285174 0.594073081146571 0.32701052661333 NA NA NA 0.465139842912427 98.5152882609085 a3844 loss_cnaBRCA36_(FAT1,IRF2) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 9 33 1.38629436111989 0.693147180559945 3.12835897538834 3.51663092112711 -0.388271945738775 1.14433777779456 1.01299069870894 0.373127702335931 0.339298372624802 0.383292705681929 0.327051358558539 NA NA NA 0.374254501499755 98.5152882609085 a3845 MACF1_mut 1004 Vinblastine Microtubules 3 42 -2.30258509299405 NA -4.16272695739199 -3.40504845552587 -0.757678501866123 1.90214863043977 1.24082643575861 0.592311423373757 0.398327706752837 0.610624080879529 0.327168489104538 NA NA NA 0.563249092447631 98.5228337989157 a3846 loss_cnaBRCA18 178 BAY 61-3606 SYK 16 32 2.07944154167984 NA 2.77200564737002 3.25762640880552 -0.4856207614355 1.31417446530285 1.72374984276056 0.303182917614899 0.369525336442746 0.28172345510285 0.327260805007561 NA NA NA 0.285273474263009 98.5228337989157 a3847 gain_cnaBRCA63 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 6 39 2.30258509299405 NA 1.77907083747386 1.30167065807802 0.477400179395836 1.43744249904986 1.04606610843862 0.434489507768893 0.332117757553012 0.456376681688323 0.327331670804412 NA NA NA 0.464564761021517 98.5228337989157 a3848 gain_cnaBRCA15 1261 rTRAIL TR10A (DR4), TR10B (DR5) 22 25 -2.30258509299405 NA 0.0185463050351033 -0.280659680374846 0.29920598540995 1.08152733880873 0.990578266776741 0.289362690291511 0.276651338041547 0.30205183724002 0.327534110476346 NA NA NA 0.33051820813178 98.5442957211604 a3849 gain_cnaBRCA58_(CCND1) 1129 PF-4708671 RPS6KB1 (p70S6KA) 6 37 2.30258509299405 NA 4.23711222608481 3.73953795533484 0.497574270749969 0.97308389778019 1.16248961532092 0.436057142239954 0.51133748270323 0.428024701633664 0.327595218555253 NA NA NA 0.293715195578311 98.5442957211604 a3850 loss_cnaBRCA34 1495 AZD-2281 PARP1, PARP2 5 40 2.30258509299405 NA 4.46887963838893 3.93991775427612 0.528961884112815 0.77447049572836 1.15633322762467 0.469651450141296 0.682998109069794 0.457447621045539 0.327658293916977 NA NA NA 0.222027306955505 98.5442957211604 a3851 BRCA1_mut 1001 AICAR AAPK1 (AMPK) agonist 4 41 7.60090245954208 NA 8.38848800293613 7.67506820231081 0.713419800625324 0.924198603883054 1.4044367733874 0.518330569998578 0.771933432519661 0.507975733862769 0.327946763139336 NA NA NA 0.228197041962386 98.5808900522516 a3852 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 207 AS601245 JNK 9 39 2.07944154167984 NA 2.6463733096481 2.1784685754972 0.467904734150895 1.26097371618464 1.2835671515156 0.365645837601648 0.371066207126542 0.364534674791581 0.327950244823623 NA NA NA 0.336812458650758 98.5808900522516 a3853 loss_cnaBRCA18 225 Genentech Cpd 10 AURKA, AURKB 16 33 2.32630161961136 NA 2.69182080715602 3.17624169645436 -0.484420889298337 1.41724509992842 1.69155178610129 0.301051644026626 0.341804596341737 0.286376623688735 0.328098356799262 NA NA NA 0.300231180924767 98.599815037079 a3854 BRCA1_mut 163 JQ1 BRD4 4 43 0.940007258491471 NA 1.00309581012573 0.251993110580447 0.751102699545286 1.85637010152937 1.42074350896448 0.516629449410961 0.404608272308679 0.528668753230999 0.328283962769596 NA NA NA 0.482874618701276 98.6299949379645 a3855 loss_cnaBRCA23 273 CUDC-101 HDAC, EGFR 3 46 1.63315443905142 NA -0.890478651055776 0.0296882369505809 -0.920166888006356 0.551680095689358 1.5943071039219 0.588280928917145 1.66793563008024 0.577157867353663 0.32857641593956 NA NA NA 0.0708795338305467 98.6922521443363 a3856 CDH1_mut 282 EKB-569 EGFR 4 43 0.916290731874155 2.99573227355399 2.57429871596212 1.48539477634896 1.08890393961316 0.899997483251988 2.17027713363084 0.516184423186036 1.20989664957572 0.501734973261889 0.328696360368675 NA NA NA 0.0923907073466675 98.7026752258529 a3857 PIK3CA_mut 1054 PD-0332991 CDK4, CDK6 14 28 1.38629436111989 0.693147180559945 2.56781903413303 3.04044759040707 -0.472628556274041 1.61085678876841 1.38243207082858 0.323586578027065 0.293401970658976 0.341881938539493 0.328814453173158 NA NA NA 0.35779374924902 98.712537031164 a3858 MACF1_mut 1046 681640 WEE1, CHEK1 3 33 0.693147180559945 NA 2.05246822669699 2.68664276150131 -0.634174534804322 1.20821631976179 1.05235217106499 0.597064596562715 0.52488492700492 0.602625767534199 0.32911005556 NA NA NA 0.461838591337284 98.7418093456369 a3859 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1241 CHIR-99021 GSK3B 6 40 2.30258509299405 NA 4.59766107283292 4.17656099543505 0.421100077397875 0.794308251375119 0.99545227046358 0.432035885605629 0.53014692554038 0.423023875571422 0.329117138942446 NA NA NA 0.278136778035688 98.7418093456369 a3860 loss_cnaBRCA60 140 Vinorelbine Microtubules 3 44 -2.74887219562247 NA -4.50389994677669 -3.538175104521 -0.965724842255697 0.707439161835057 1.67218227575049 0.588357911292111 1.36509949456383 0.57752366847823 0.329402161208745 NA NA NA 0.118455103058815 98.7418093456369 a3861 loss_cnaBRCA7_(FAS,PTEN) 194 AUY922 HSP90 4 43 -1.36257783450257 NA -1.58152816993057 -2.4693023217787 0.887774151848126 1.51766998793171 1.73615850210936 0.515412086715495 0.584958626649784 0.511343953198696 0.329412894063483 NA NA NA 0.334776785626458 98.7418093456369 a3862 gain_cnaBRCA19 1005 Cisplatin DNA crosslinker 4 41 1.79175946922805 2.30258509299405 4.225119094544 3.61593374251709 0.60918535202691 0.866547131638564 1.19912913808329 0.516707991703195 0.703003137146153 0.508023141694849 0.329446378436864 NA NA NA 0.263091208353615 98.7418093456369 a3863 loss_cnaBRCA34 328 SNX-2112 HSP90 5 43 0.940007258491471 NA -0.431310914001628 0.515908662661837 -0.947219576663465 1.48786955167695 2.07852421641158 0.465696812667591 0.636628107347092 0.455717363879825 0.329484081437526 NA NA NA 0.246168907364806 98.7418093456369 a3864 gain_cnaBRCA31 265 Tubastatin A HDAC6 16 33 2.99573227355399 NA 4.48311369227738 4.7929210938208 -0.309807401543417 1.21618768553499 0.933426382895093 0.300165972573755 0.25473650590956 0.331903412224675 0.329508896546801 NA NA NA 0.377804408109114 98.7418093456369 a3865 gain_cnaBRCA13_(FGFR1,WHSC1L1) 204 Tipifarnib Farnesyl-transferase (FNTA) 10 38 2.77258872223978 NA 2.03851066000965 1.50983596631492 0.528674693694734 2.0902771843169 1.3307072216934 0.35018639422803 0.252920855502475 0.397288513262869 0.329628926903444 NA NA NA 0.463078445601935 98.7506012661215 a3866 loss_cnaBRCA22_(SYNCRIP,ZNF292) 63 BMS-509744 ITK 3 9 2.32630161961136 NA 3.04986550302466 3.77826530263654 -0.728399799611883 1.06989491238738 1.065513116856 0.683051391799248 0.680814340902432 0.683614108628867 0.329708804296421 NA NA NA 0.37296063622287 98.7506012661215 a3867 BRCA1_mut 179 5-Fluorouracil DNA antimetabolite 4 45 3.46573590279973 NA 4.80275963799581 3.97380709250357 0.82895254549224 0.802993734274175 1.65458340112113 0.513693602052992 1.0323275389459 0.501003784354749 0.329881492032495 NA NA NA 0.132214847243511 98.7767725948865 a3868 gain_cnaBRCA58_(CCND1) 158 PF-562271 FAK 9 36 0.940007258491471 NA 2.71053150901876 2.23892987968747 0.471601629331289 0.76877621007954 1.37599746279999 0.367022280856272 0.61344461905565 0.342734374212898 0.330219647655966 NA NA NA 0.183709038014149 98.8267279348649 a3869 gain_cnaBRCA13_(FGFR1,WHSC1L1) 277 ABT-869 VEGFR and PDGFR family 11 37 0.0237165266173161 NA 2.8145492737185 2.65437064566169 0.160178628056808 0.58852701454351 0.437004049771726 0.33787147605866 0.272168692512867 0.366538086181305 0.330336813222371 NA NA NA 0.417379711940012 98.8267279348649 a3870 gain_cnaBRCA16 63 BMS-509744 ITK 3 9 2.32630161961136 NA 3.05055358165727 3.77803594309234 -0.727482361435063 1.07062048065914 1.06550719857075 0.682100946648582 0.679496025507734 0.682756871479512 0.330350005487182 NA NA NA 0.373742746484489 98.8267279348649 a3871 TP53_mut 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 23 3 2.30258509299405 NA 4.61633099278093 5.2183244040449 -0.601993411263966 1.02527347664749 0.366093417386275 0.609738854015226 0.587153988643506 1.64437103393418 0.330472113220401 NA NA NA 0.0827231401650756 98.8267279348649 a3872 gain_cnaBRCA64_(SDHC) 140 Vinorelbine Microtubules 8 39 -2.74887219562247 NA -3.07980360482756 -3.7064865538624 0.626682949034831 1.82887669274145 1.60456545028794 0.381780895308136 0.342660033627223 0.390562409855188 0.330544808349873 NA NA NA 0.390382758559726 98.8267279348649 a3873 loss_cnaBRCA57 1032 Afatinib ERBB2, EGFR 5 40 -0.693147180559945 NA 1.04820007436151 0.195755651399344 0.852444422962164 1.87046531023135 1.82163101343283 0.466778538580639 0.455739231462533 0.467956691929476 0.330593024733769 NA NA NA 0.379548326421345 98.8267279348649 a3874 gain_cnaBRCA14_(RAD21) 37 Crizotinib MET, ALK 6 8 0.693147180559945 NA 2.41067739242232 2.83350379964244 -0.42282640722012 0.924327711593385 0.642568778776444 0.547306217511963 0.45744209755568 0.658025134718264 0.330860450051216 NA NA NA 0.363630280432517 98.8267279348649 a3875 POLR2B_mut 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 3 40 0.693147180559945 NA 3.43038100127326 2.86927152043425 0.561109480839011 0.595753106942187 0.967509275377495 0.588939098268882 0.941849021516664 0.579952559752031 0.330962087190431 NA NA NA 0.237021947715559 98.8267279348649 a3876 PIK3CA_mut 134 Etoposide TOP2 16 31 2.77258872223978 NA 2.04760446648408 2.69877768681803 -0.651173220333952 2.48750713513031 1.96423223919762 0.302472285428368 0.261777428147896 0.33151539178481 0.331057186965648 NA NA NA 0.371146655135678 98.8267279348649 a3877 loss_cnaBRCA60 275 I-BET BRD2, BRD3, BRD4 3 46 2.99573227355399 NA 3.29422237395709 4.08750966924752 -0.793287295290434 0.788956240428229 1.37530935101376 0.58522086764259 1.00548960086792 0.576806443369043 0.331073108440493 NA NA NA 0.214009606982678 98.8267279348649 a3878 loss_cnaBRCA33 204 Tipifarnib Farnesyl-transferase (FNTA) 6 42 2.77258872223978 NA 1.05375862139169 1.7008647998027 -0.647106178411012 1.24246673647379 1.53922612076903 0.428604521510791 0.520823744744706 0.420410081195676 0.331209281232987 NA NA NA 0.283928048919663 98.8267279348649 a3879 loss_cnaBRCA17 287 KIN001-244 PDPK1 (PDK1) 11 38 2.99573227355399 NA 3.23312042485029 3.54902293099076 -0.315902506140476 0.781264740247865 0.978716595473188 0.336000424037182 0.404347578824884 0.322772197387482 0.331438357349085 NA NA NA 0.279282453126654 98.8267279348649 a3880 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1038 NU-7441 PRKDC (DNAPK) 16 27 0.693147180559945 NA 3.07623315361604 2.78420241541031 0.292030738205726 0.658151639599615 1.07183807472633 0.310074098941376 0.443713455433131 0.272457888081919 0.331461353915571 NA NA NA 0.274862584060113 98.8267279348649 a3881 gain_cnaBRCA10_(MDM2,NUP107) 1248 FK866 NAMPT 3 41 0 NA -2.13195592251822 -0.542321720208638 -1.58963420230958 3.43373389214207 2.66392069444209 0.587545711958428 0.462946242266292 0.596727299587462 0.331550884542371 NA NA NA 0.508848940831284 98.8267279348649 a3882 gain_cnaBRCA31 87 GW843682X PLK1 3 9 -1.36257783450257 NA -0.943298150675339 -2.23850360419916 1.29520545352382 0.875128362739654 2.08317408043124 0.68028824364063 1.48001768502746 0.62174614483284 0.331575497967147 NA NA NA 0.166441364808395 98.8267279348649 a3883 gain_cnaBRCA64_(SDHC) 1371 PLX4720 (rescreen) BRAF 9 38 2.30258509299405 NA 4.42662467369581 4.77358692353458 -0.346962249838767 1.96615218531777 0.519891869266928 0.363818895763076 0.176467647026363 0.667373872047663 0.331639017212499 NA NA NA 0.613320081028497 98.8267279348649 a3884 gain_cnaBRCA27_(CLTC,PPM1D) 266 Zibotentan, ZD4054 Endothelin A Receptor 9 40 2.99573227355399 NA 5.59695004232745 5.77468448649249 -0.177734444165033 0.490209573246262 0.491293830954893 0.361903941765031 0.362568284801215 0.361768117095187 0.331640500129447 NA NA NA 0.34547858611553 98.8267279348649 a3885 PTEN_mut 1043 JNK Inhibitor VIII JNK 6 37 2.30258509299405 NA 4.52068555991105 4.84219263327355 -0.321507073362501 0.831283991307226 0.730616959949625 0.432352009536695 0.38675961130554 0.440048740977308 0.331674191831356 NA NA NA 0.404550212475824 98.8267279348649 a3886 ASH1L_mut 333 T0901317 LXR 3 45 2.32630161961136 NA 4.31740677481737 4.76330483477719 -0.445898059959827 0.709305790044756 0.764668345470035 0.584903327802283 0.628640096017956 0.583126086755608 0.331766909701144 NA NA NA 0.390978691534718 98.8267279348649 a3887 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 263 FR-180204 ERK 6 43 2.99573227355399 NA 5.08371349423228 5.39614136310983 -0.312427868877553 1.14352813262845 0.665235441191302 0.427313522655401 0.273213976956933 0.469650066024833 0.331847788500745 NA NA NA 0.539573117444865 98.8267279348649 a3888 loss_cnaBRCA22_(SYNCRIP,ZNF292) 203 BMS-345541 IKBKB 19 30 2.77258872223978 NA 3.70930421668104 3.42024983364978 0.289054383031264 1.12199367572447 0.92577141882319 0.287486095135191 0.257625679435868 0.312230834905986 0.33185023283373 NA NA NA 0.35470267564103 98.8267279348649 a3889 loss_cnaBRCA17 53 CGP-60474 CDK1,CDK2,CDK5,CDK7,CDK9 3 9 -1.36257783450257 NA -2.45674173047116 -1.44804237921691 -1.00869935125425 0.578128225748348 1.63392418343916 0.679661451440088 1.74476752099165 0.617347708956172 0.332000035054378 NA NA NA 0.146409783479452 98.8267279348649 a3890 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1268 XAV 939 TNKS1 (tankyrase-1) 6 41 1.6094379124341 NA 3.31123157031553 3.71269309290696 -0.401461522591434 0.545926164267318 0.974476292525889 0.428640055844026 0.735376959135547 0.411976695247071 0.33201137547856 NA NA NA 0.166361416115787 98.8267279348649 a3891 loss_cnaBRCA29_(MAP2K4) 1072 BMS-708163 g-secretase 7 39 1.6094379124341 NA 4.00920264206436 3.62592489424337 0.383277747820988 1.04033251324263 0.937472731740921 0.402537728707075 0.368418503643938 0.40884148929775 0.332132477490965 NA NA NA 0.389591481390821 98.835187358596 a3892 loss_cnaBRCA18 228 KIN001-102 AKT1 16 33 2.32630161961136 NA 1.66169669032096 2.08043421690576 -0.418737526584801 1.03739182568912 1.54479551818624 0.298471444974778 0.403644521014655 0.271063400725324 0.332218922568333 NA NA NA 0.268748391576192 98.835187358596 a3893 gain_cnaBRCA15 1502 Bicalutamide ANDR (androgen receptor) 20 25 2.30258509299405 NA 4.65333765227737 4.48227551748621 0.171062134791161 0.711151722040777 0.453912714283189 0.294034783844471 0.2405423898859 0.37686129823726 0.332511384051586 NA NA NA 0.357455681702516 98.835187358596 a3894 BRCA1_mut 1067 CCT007093 PPM1D 4 42 1.88706964903238 NA 4.54572889693017 4.04181787409446 0.503911022835715 0.21275222580483 1.016493600516 0.51272996396244 2.36853466951731 0.495734574797045 0.332511976190319 NA NA NA 0.0141913108818538 98.835187358596 a3895 CDH1_mut 1219 PFI-1 BRD2, BRD3, BRD4 5 42 2.30258509299405 NA 3.58455995064461 3.12342405193607 0.461135898708539 1.81088943961866 0.8757381451249 0.463402373757739 0.254646080881474 0.526568245628687 0.332553817778409 NA NA NA 0.602820411123529 98.835187358596 a3896 loss_cnaBRCA36_(FAT1,IRF2) 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 3 23 2.30258509299405 NA 2.03382877789882 2.77733136455695 -0.743502586658131 1.27149068863493 1.22062586491405 0.606968002882399 0.584748746729991 0.609115870824584 0.332631008583854 NA NA NA 0.421543312496802 98.835187358596 a3897 loss_cnaBRCA57 1502 Bicalutamide ANDR (androgen receptor) 5 40 2.30258509299405 NA 4.79866164750314 4.52825831862967 0.270403328873468 0.594032733103559 0.5805070420032 0.464787412400407 0.455199375059232 0.465805424065773 0.332637296084678 NA NA NA 0.380168141731521 98.835187358596 a3898 gain_cnaBRCA64_(SDHC) 277 ABT-869 VEGFR and PDGFR family 8 40 0.0237165266173161 NA 2.54130946024871 2.72103200545991 -0.179722545211198 0.684479415187823 0.42550978160253 0.379055637838858 0.2625682251699 0.422369950073386 0.332839058924058 NA NA NA 0.494358343271172 98.8697656049684 a3899 gain_cnaBRCA31 300 CX-5461 RNA Pol I 16 33 2.32630161961136 NA 4.25422562184855 3.74661483086017 0.507610790988372 1.43200467602194 1.81675622768336 0.297993123377307 0.354475651852268 0.279405009463297 0.332986575724106 NA NA NA 0.294831021045871 98.8862596099515 a3900 POLR2B_mut 222 BX-912 PDPK1 (PDK1) 3 46 2.32630161961136 NA 4.70854673052915 3.82999169613116 0.878555034397997 1.15577510271611 1.52146997936609 0.582705730588915 0.760143588777234 0.577438297378725 0.333134658324335 NA NA NA 0.317052849638856 98.8862596099515 a3901 PIK3CA_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 15 28 2.30258509299405 NA 3.57609037293192 3.9337222182114 -0.357631845279486 1.50934618339619 0.892756820860009 0.313331438989751 0.236944876671551 0.400592677561369 0.33319872189898 NA NA NA 0.409972372966459 98.8862596099515 a3902 gain_cnaBRCA58_(CCND1) 229 LY317615 PRKCB (PKCbeta) 10 39 2.99573227355399 2.32630161961136 2.91494400793195 3.47233667817838 -0.557392670246435 1.97567625997453 1.50996477945787 0.346290875887812 0.282127533512813 0.369142828911916 0.333592522102204 NA NA NA 0.421863288851687 98.8862596099515 a3903 gain_cnaBRCA62 171 AKT inhibitor VIII AKT1, AKT2, AKT3 9 38 0.940007258491471 NA 2.25476998487252 1.8019481347321 0.452821850140418 1.33038380557014 1.23174598587068 0.362300763016292 0.340369334206049 0.367626000274995 0.333639497997475 NA NA NA 0.371041479004967 98.8862596099515 a3904 loss_cnaBRCA22_(SYNCRIP,ZNF292) 312 AV-951 VEGFR 18 30 -2.05572501506252 NA 0.748764651173018 0.56238256676315 0.186382084409868 0.619432976375491 0.651584945784208 0.29127165052987 0.300891446723505 0.286044184439452 0.333701589632125 NA NA NA 0.328704222186453 98.8862596099515 a3905 BRCA2_mut 276 CAY10603 HDAC6 6 43 2.99573227355399 NA 1.54470502026105 1.12402831169036 0.420676708570689 1.53834586841093 0.901799921689885 0.425276703243797 0.273460420838414 0.466485634399238 0.334134583746702 NA NA NA 0.539321574194328 98.8862596099515 a3906 gain_cnaBRCA64_(SDHC) 345 KIN001-270 CDK9 8 41 2.99573227355399 NA 5.32485192314034 5.06519383013496 0.259658093005378 1.04337000302872 0.60536306301327 0.377140943826773 0.248864824800059 0.428929528195688 0.334179586685461 NA NA NA 0.514713027469669 98.8862596099515 a3907 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 330 XMD13-2 RIPK 6 42 2.32630161961136 NA 4.17313708055305 3.65643326772208 0.516703812830962 1.08787409513549 1.22771323683392 0.425868487932349 0.474966556462225 0.420866858260369 0.334273728096975 NA NA NA 0.320273663670193 98.8862596099515 a3908 loss_cnaBRCA42 192 LFM-A13 BTK 3 45 2.77258872223978 NA 5.25066922627572 4.7651235174611 0.485545708814628 0.500370784863408 0.846590644487547 0.581819551088664 0.970371819264333 0.573530680945022 0.334296401596642 NA NA NA 0.22641762262346 98.8862596099515 a3909 loss_cnaBRCA38 312 AV-951 VEGFR 4 44 -2.05572501506252 NA 0.333392753411801 0.659447038871855 -0.326054285460053 0.257243375755425 0.658356881022807 0.509533178754994 1.2674934174789 0.495254617759146 0.334325477424807 NA NA NA 0.0822753670140805 98.8862596099515 a3910 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1069 EHT 1864 Rac GTPases 18 28 2.30258509299405 NA 3.71513595187857 3.46260538328819 0.252530568590378 0.975915998703551 0.771623329071116 0.294891225037409 0.258762607566482 0.327271816540819 0.334346894501445 NA NA NA 0.361134619151929 98.8862596099515 a3911 loss_cnaBRCA29_(MAP2K4) 306 TG101348 JAK2 7 41 2.32630161961136 NA 2.78884267855187 3.29933585291899 -0.510493174367125 1.21323168333244 1.28938836754944 0.398912568279759 0.420771383883521 0.395918861388014 0.334446808822537 NA NA NA 0.336223591965506 98.8862596099515 a3912 BRCA2_mut 1494 SN-38 TOP1 6 42 -2.99573227355399 NA -3.92912563830789 -3.21445463444012 -0.714671003867777 1.85138122248081 1.65676992820083 0.425648625251778 0.386020445270658 0.431364060696027 0.334520798529721 NA NA NA 0.403845544807258 98.8862596099515 a3913 MLL3_mut 167 OSU-03012 PDPK1 (PDK1) 3 45 2.77258872223978 NA 1.60446940604567 2.29087966902022 -0.686410262974544 0.366151293269878 1.20492382974119 0.581255678071881 1.87466294832561 0.569671082961303 0.334760308121292 NA NA NA 0.0495920840270343 98.8862596099515 a3914 gain_cnaBRCA16 292 Masitinib KIT 16 32 2.99573227355399 NA 3.79416120230426 4.11841047093346 -0.324249268629198 1.25536049981444 0.994757424175028 0.298400110914971 0.258291756572815 0.325958128835384 0.334870614990379 NA NA NA 0.376115519342953 98.8862596099515 a3915 ARID1A_mut 1010 Gefitinib EGFR 5 40 -0.693147180559945 NA 0.972846522476353 1.45327922620399 -0.480432703727636 1.40700297361942 0.993243485186669 0.462528695681803 0.341458200682941 0.48370083558851 0.334966509720148 NA NA NA 0.49552780076607 98.8862596099515 a3916 gain_cnaBRCA58_(CCND1) 1069 EHT 1864 Rac GTPases 8 38 2.30258509299405 NA 3.82967675772306 3.50494694221313 0.324729815509923 1.11854689120082 0.797134671112892 0.379190743070365 0.290313994043921 0.407371335456483 0.33498840509443 NA NA NA 0.456158197765632 98.8862596099515 a3917 gain_cnaBRCA13_(FGFR1,WHSC1L1) 194 AUY922 HSP90 10 37 -1.36257783450257 NA -1.92271942855662 -2.52105184407135 0.598332415514734 2.44673510529589 1.48787372212999 0.347286086748633 0.24454319318003 0.402139245162676 0.335064788886735 NA NA NA 0.476539646507654 98.8862596099515 a3918 gain_cnaBRCA48 200 LAQ824 HDAC 5 43 0.0237165266173161 NA -2.10429235201557 -2.75192962591632 0.647637273900747 1.17597159246232 1.42708687455527 0.460286424206907 0.550725270960571 0.453817693546213 0.335076134383974 NA NA NA 0.302526752894586 98.8862596099515 a3919 gain_cnaBRCA8_(CHD4,WNK1) 281 CH5424802 ALK 4 44 1.63315443905142 NA 3.07998984180811 3.62026233370542 -0.540272491897317 2.14046653095245 0.941939154959673 0.508654251730655 0.252408754860049 0.573574725132271 0.335151463753008 NA NA NA 0.650083424235405 98.8862596099515 a3920 ARID1A_mut 309 Y-39983 ROCK 5 44 2.99573227355399 NA 5.38074679466588 4.88432571504601 0.496421079619867 1.0958285981478 1.07914102472896 0.459406140280519 0.453009786803275 0.460015019579623 0.335317226705649 NA NA NA 0.381156580739495 98.8862596099515 a3921 MLL3_mut 1203 QL-XII-61 BTK 3 20 2.30258509299405 NA 3.4290210426802 4.34463953737812 -0.915618494697917 2.05883543469107 1.42935343966486 0.610118120115853 0.444726411479947 0.640582286570493 0.335631463445506 NA NA NA 0.525571250666409 98.8862596099515 a3922 TP53_mut 268 YM155 BIRC5 (Survivin) 38 11 1.63315443905142 NA -3.71477070168921 -3.18382140297031 -0.5309492987189 1.55939769962656 1.71674045330637 0.333055638229269 0.340483571859861 0.309277560097284 0.335651291169086 NA NA NA 0.371221049140034 98.8862596099515 a3923 gain_cnaBRCA58_(CCND1) 1026 17-AAG HSP90 8 35 0 NA -1.449572902724 -0.769722935369131 -0.679849967354868 1.27541921527131 1.86833091852814 0.381695979368632 0.533040398964233 0.363880916711719 0.335764570129741 NA NA NA 0.236082818729459 98.8862596099515 a3924 MLL3_mut 1061 SB590885 BRAF 3 39 1.6094379124341 NA 3.42404581456868 4.05713214886451 -0.633086334295825 0.18318431672845 1.11198990061293 0.583700898779423 3.45600729146646 0.569327413807324 0.33580059293719 NA NA NA 0.00606361525955112 98.8862596099515 a3925 loss_cnaBRCA24 258 STF-62247 stimulates autophagy 3 46 2.32630161961136 NA 4.10957839792386 4.66483841673809 -0.555260018814227 1.10368787042797 0.95192614056294 0.579075351515616 0.503095153704025 0.583301576828075 0.336125374193438 NA NA NA 0.47733379679238 98.8862596099515 a3926 loss_cnaBRCA36_(FAT1,IRF2) 1007 Docetaxel Microtubules 8 37 -4.38202663467388 NA -5.06722410629102 -4.48350788238902 -0.583716223902007 1.48159419531825 1.55002881570084 0.379259220983335 0.393978476526511 0.376584111204463 0.336146148982805 NA NA NA 0.338661608275128 98.8862596099515 a3927 gain_cnaBRCA62 1039 SL 0101-1 RSK, AURKB, PIM3 7 36 2.30258509299405 NA 4.32525039412449 4.7117462968008 -0.386495902676315 1.50197125646614 0.834337641081166 0.401993511227271 0.257325765065351 0.463236804437445 0.336179626929413 NA NA NA 0.530393188059206 98.8862596099515 a3928 gain_cnaBRCA61_(NOTCH2) 196 Phenformin AAPK1 (AMPK) agonist 3 45 8.29404964010203 NA 8.18368546000776 7.13656825898663 1.04711720102113 0.497448720889097 1.84442365060351 0.579522633657093 2.10497516035342 0.567720545482328 0.336188789912848 NA NA NA 0.033410938603801 98.8862596099515 a3929 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1001 AICAR AAPK1 (AMPK) agonist 7 38 7.60090245954208 NA 7.27336364704974 7.82416323097735 -0.550799583927617 1.61546048774826 1.33420135664803 0.400028697263472 0.340955156814363 0.412830927792949 0.336201224305794 NA NA NA 0.421220830066963 98.8862596099515 a3930 PIK3CA_mut 1008 Methotrexate Dihydrofolate reductase (DHFR) 16 29 -1.6094379124341 NA 0.894733975748392 0.565638266834811 0.329095708913581 1.01570273038807 1.12267430220062 0.302879825645095 0.324007900212932 0.293135514252443 0.336204118278603 NA NA NA 0.323612372684691 98.8862596099515 a3931 loss_cnaBRCA42 140 Vinorelbine Microtubules 3 44 -2.74887219562247 NA -4.49138762562193 -3.539028217327 -0.952359408294924 0.710006523624649 1.67263226674838 0.580042949127881 1.34133895479304 0.569377637408803 0.336211351993798 NA NA NA 0.123167307599311 98.8862596099515 a3932 loss_cnaBRCA23 186 Bexarotene Retinioic acid X family agonist 3 44 2.07944154167984 NA 2.98699370261606 3.64650171856627 -0.659508015950209 1.35519484725939 1.12592322473012 0.579993705076078 0.486651803084944 0.585748656271206 0.336251955305956 NA NA NA 0.490029466440557 98.8862596099515 a3933 gain_cnaBRCA10_(MDM2,NUP107) 194 AUY922 HSP90 4 43 -1.36257783450257 NA -1.59285017129547 -2.4682491123494 0.875398941053934 1.42286038575098 1.74242967067337 0.508075535853541 0.615238817399433 0.50240130536553 0.336271488584226 NA NA NA 0.314910403210948 98.8862596099515 a3934 loss_cnaBRCA57 1527 GDC0941 (rescreen) PI3K 5 40 1.38629436111989 NA 1.45330789956136 0.921574334088896 0.531733565472465 1.41193880489895 1.12295592978954 0.461214824043817 0.376598166738906 0.473512407180681 0.336326381032256 NA NA NA 0.456988838922878 98.8862596099515 a3935 loss_cnaBRCA20 1259 BMN-673 PARP1 3 43 2.30258509299405 NA 4.14802282968887 3.2467600319483 0.901262797740571 0.993442639073707 1.57441560440012 0.58043726202962 0.907211712375176 0.572442749691857 0.336358469378622 NA NA NA 0.250605776093716 98.8862596099515 a3936 loss_cnaBRCA17 281 CH5424802 ALK 10 38 1.63315443905142 NA 3.28493694578094 3.65163506822267 -0.366698122441735 0.923810279067785 1.09324003778504 0.345218827275742 0.396940942042526 0.335423246284215 0.33646526693714 NA NA NA 0.298886803665751 98.8862596099515 a3937 gain_cnaBRCA61_(NOTCH2) 345 KIN001-270 CDK9 3 46 2.99573227355399 NA 5.48158059972557 5.08319610046694 0.398384499258631 0.212385102357262 0.702266907444029 0.57857809176402 1.87576480100046 0.567283599776317 0.336536402606749 NA NA NA 0.0494603271369525 98.8862596099515 a3938 NF1_mut 1028 VX-702 p38 4 41 0.693147180559945 NA 3.74311076290269 3.39597491169774 0.347135851204952 0.524923247838893 0.692219084207746 0.509086051684486 0.661307824780305 0.501482636241174 0.336552158485876 NA NA NA 0.287024401032971 98.8862596099515 a3939 loss_cnaBRCA60 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 3 42 -0.669430653942629 NA -4.80024238322125 -3.39233071215298 -1.40791167106827 0.454454499594739 2.48068903754608 0.580751278012056 3.09802559403369 0.567548632560974 0.336593624763952 NA NA NA 0.00788803404423016 98.8862596099515 a3940 gain_cnaBRCA12_(TERT) 276 CAY10603 HDAC6 9 40 2.99573227355399 NA 0.88630775443588 1.24061694335822 -0.354309188922344 0.81441934083493 1.02146220894433 0.358146491716334 0.435045155680011 0.346864706124097 0.336635083468805 NA NA NA 0.280497916415257 98.8862596099515 a3941 gain_cnaBRCA15 230 GSK429286A ROCK2 22 27 2.99573227355399 2.32630161961136 5.54290369718468 5.29354793987762 0.249355757307055 0.823495203687327 0.948439354691779 0.278680767112493 0.302801711765322 0.262911651729266 0.3368683312903 NA NA NA 0.329894284656488 98.8862596099515 a3942 gain_cnaBRCA64_(SDHC) 1373 Dabrafenib BRAF 9 37 2.30258509299405 NA 3.74133426907664 4.32970517916001 -0.588370910083363 3.20994891190419 0.979984851103749 0.360809605304981 0.183296035616446 0.600387760505365 0.336963880439929 NA NA NA 0.600794501257319 98.8862596099515 a3943 loss_cnaBRCA57 173 FH535 unknown 5 43 3.46573590279973 NA 1.04873790628466 1.63395855437315 -0.585220648088494 1.10237938364986 1.29225663789081 0.458325469932762 0.530870457819058 0.452867202170986 0.337118436103822 NA NA NA 0.317302662426213 98.8862596099515 a3944 gain_cnaBRCA64_(SDHC) 1262 UNC1215 LMBL3 9 37 0 NA 2.92938807409079 2.7157146374618 0.213673436628997 0.845136181635925 0.519806154883151 0.360692040365348 0.252827226276587 0.411063690996558 0.337119683644112 NA NA NA 0.485404288226292 98.8862596099515 a3945 gain_cnaBRCA14_(RAD21) 1164 XMD8-92 MAP2K5 (ERK5) 13 13 2.30258509299405 NA 4.13334630008992 3.63563167340331 0.497714626686612 1.41614708993199 1.16247602471183 0.384176835474099 0.351456872118075 0.428150444487653 0.337122293183345 NA NA NA 0.337489251927095 98.8862596099515 a3946 loss_cnaBRCA7_(FAS,PTEN) 303 PIK-93 PI4K, PI3K 4 45 2.99573227355399 NA 3.45053905887765 2.73294836773781 0.717590691139849 0.867089452374471 1.44833739400387 0.505925894248475 0.827585538233421 0.495458236534307 0.337173535129016 NA NA NA 0.202764043422063 98.8862596099515 a3947 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 308 XL-880 MET 9 40 1.63315443905142 NA 1.38040861987164 1.95287633618104 -0.572467716309402 1.06449422063034 1.68935797764421 0.357720280090718 0.537783771123166 0.338867027524682 0.337204762208092 NA NA NA 0.213364052753135 98.8862596099515 a3948 gain_cnaBRCA15 1028 VX-702 p38 21 24 0.693147180559945 NA 3.53227859079672 3.33456516768695 0.197713423109773 0.767747301240154 0.597311301259248 0.289943376112359 0.257524087405326 0.33100566269708 0.337305681034102 NA NA NA 0.346079616443884 98.8862596099515 a3949 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1373 Dabrafenib BRAF 6 40 2.30258509299405 NA 4.81680497129255 4.12425675557137 0.692548215721176 0.736609622287979 1.71190553654063 0.42468812137559 0.940183503943455 0.404548148796024 0.337321066474125 NA NA NA 0.107391253532432 98.8862596099515 a3950 gain_cnaBRCA8_(CHD4,WNK1) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 3 45 2.07944154167984 NA 2.58660819705774 3.25614980106683 -0.669541604009093 1.31317837480171 1.15056068455594 0.578135027202166 0.509863409919613 0.58192637120006 0.337335456826417 NA NA NA 0.472294777194845 98.8862596099515 a3951 gain_cnaBRCA14_(RAD21) 302 PI-103 PI3Ka, PRKDC (DNAPK) 21 27 2.32630161961136 NA 0.835119483783396 1.35656601822134 -0.521446534437943 1.95749011042164 1.76149288456078 0.281975279824526 0.266385271456428 0.296025342485538 0.337548667437687 NA NA NA 0.344614842252552 98.9082052833041 a3952 gain_cnaBRCA62 1371 PLX4720 (rescreen) BRAF 8 39 2.30258509299405 NA 4.40939558857585 4.76822462689666 -0.358829038320807 2.05848104230078 0.544989296392327 0.376164611399415 0.174317387892842 0.658414836210825 0.33763385706036 NA NA NA 0.639018728662052 98.9082052833041 a3953 MACF1_mut 1264 SGC0946 Q8TEK3 (DOT1L) 3 43 -0.693147180559945 NA 2.27824766348905 1.92786245400707 0.35038520948198 0.353946665533141 0.614751650502326 0.578824308042159 0.989937873702537 0.569962210261124 0.337688854495541 NA NA NA 0.219319479674351 98.9082052833041 a3954 loss_cnaBRCA36_(FAT1,IRF2) 1268 XAV 939 TNKS1 (tankyrase-1) 9 38 1.6094379124341 NA 3.38943825807717 3.72586478706274 -0.33642652898557 0.812454775782006 0.961609978067018 0.35911133361981 0.414086468581285 0.349857568722237 0.337868444528834 NA NA NA 0.30010655641779 98.9082052833041 a3955 loss_cnaBRCA23 223 ZSTK474 PI3K 3 46 1.63315443905142 2.32630161961136 0.130327314261359 0.963338655706738 -0.833011341445379 1.02467303341211 1.45994886977458 0.576837050437032 0.812953317090323 0.570575695280342 0.337978153189384 NA NA NA 0.291438828264753 98.9082052833041 a3956 gain_cnaBRCA62 329 QL-XI-92 DDR1 10 38 2.32630161961136 NA 3.99622591514621 4.32099540952067 -0.324769494374457 1.19565479441344 0.872247870256094 0.343933713332939 0.271624799977306 0.372336242310462 0.338249067307905 NA NA NA 0.437248375378722 98.9082052833041 a3957 loss_cnaBRCA20 163 JQ1 BRD4 3 44 0.940007258491471 NA 1.10174010905097 0.26233787882521 0.839402230225756 0.800493054159033 1.47789891022157 0.577104400219377 1.04860651302915 0.567969990653767 0.338639989162639 NA NA NA 0.199449219622766 98.9082052833041 a3958 gain_cnaBRCA64_(SDHC) 305 TPCA-1 IKK 8 41 2.99573227355399 NA 4.60901115361199 4.09429030947252 0.514720844139476 1.21562796890087 1.4040385786562 0.373632799807074 0.423419711710705 0.366600214526949 0.338650862066872 NA NA NA 0.308943581941886 98.9082052833041 a3959 gain_cnaBRCA13_(FGFR1,WHSC1L1) 341 EX-527 SIRT1 11 38 2.99573227355399 NA 5.80921522335324 5.5932774011561 0.215937822197139 0.546852331646144 0.678808455594488 0.330701090969175 0.394874099827131 0.318113041193668 0.339045298812598 NA NA NA 0.289161913402337 98.9082052833041 a3960 gain_cnaBRCA63 230 GSK429286A ROCK2 7 42 2.99573227355399 2.32630161961136 5.7078334004864 5.35511528360366 0.352718116882733 1.38872350030182 0.797327453917367 0.394160666742106 0.253987288906736 0.442375482180861 0.339240026507445 NA NA NA 0.534831428222472 98.9082052833041 a3961 POLR2B_mut 151 QS11 ARFGAP 3 45 2.32630161961136 NA 2.96318358278455 3.81360098008699 -0.850417397302447 2.06686733817815 1.44462629136756 0.575718577976274 0.411452337358067 0.588676394984751 0.339338512061239 NA NA NA 0.551760222477061 98.9082052833041 a3962 loss_cnaBRCA28_(GPS2) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 4 44 0.246860077931526 2.32630161961136 -1.02717430619841 -0.19565892274201 -0.8315153834564 0.723394767859305 1.69512199263997 0.504164627183275 1.14946281117992 0.490534243002419 0.339391825818905 NA NA NA 0.104892298657327 98.9082052833041 a3963 BRCA1_mut 224 AS605240 PI3Kgamma 4 45 2.99573227355399 2.32630161961136 3.99938727553195 3.20544514699425 0.793942128537694 2.15673280125217 1.52935473611317 0.503490641546998 0.368122619583076 0.51913536460186 0.339481523148613 NA NA NA 0.519357804712943 98.9082052833041 a3964 gain_cnaBRCA27_(CLTC,PPM1D) 156 AZD6482 PI3Kbeta 9 38 1.63315443905142 NA 2.47521480708003 1.95338493231154 0.521829874768491 1.3318185093014 1.4840422895747 0.35787310356701 0.39181755706505 0.351627361588219 0.339519796241608 NA NA NA 0.320093556242851 98.9082052833041 a3965 loss_cnaBRCA36_(FAT1,IRF2) 1059 AZD8055 MTORC1/2 9 34 0.693147180559945 NA -0.157300639602934 0.206594920686628 -0.363895560289562 1.08784080086406 0.983762026197039 0.362115082134167 0.334511777826795 0.369902019593382 0.339712342152971 NA NA NA 0.381243265791802 98.9082052833041 a3966 gain_cnaBRCA16 308 XL-880 MET 16 33 1.63315443905142 NA 2.16440550535123 1.69418918001414 0.470216325337084 1.90238718388701 1.43731025879808 0.293795237529583 0.247171726828145 0.327150190753035 0.339774380303384 NA NA NA 0.39039554949393 98.9082052833041 a3967 gain_cnaBRCA64_(SDHC) 257 NPK76-II-72-1 PLK3 8 41 2.32630161961136 NA 3.97193577217326 3.38276996046264 0.589165811710616 1.68654806977425 1.56171632731123 0.372669664821333 0.34933235658648 0.377255332103091 0.339885321488632 NA NA NA 0.383089670749872 98.9082052833041 a3968 NF1_mut 328 SNX-2112 HSP90 5 43 0.940007258491471 NA 1.24752865511274 0.320694759276445 0.926833895836296 2.17628962921941 2.02091587566199 0.455469541183545 0.425878009706241 0.45862072093065 0.340107593496076 NA NA NA 0.406900052772396 98.9082052833041 a3969 BRCA1_mut 273 CUDC-101 HDAC, EGFR 4 45 1.63315443905142 NA 0.695748686617231 -0.0908615955535451 0.786610282170776 1.20021713093429 1.58673795714354 0.50265163603483 0.65538998060997 0.495740508777417 0.340279099477999 NA NA NA 0.289685028366678 98.9082052833041 a3970 loss_cnaBRCA20 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 3 44 2.77258872223978 NA 5.56119373201817 4.97338155684158 0.587812175176591 0.090714809682311 1.04554409032795 0.575032296752066 6.47978182653027 0.562206970145293 0.3403595113533 NA NA NA 0.000996172260458354 98.9082052833041 a3971 TP53_mut 276 CAY10603 HDAC6 38 11 2.99573227355399 NA 1.10230551044826 1.428530738838 -0.326225228389738 0.960939121778189 1.08842754764155 0.329706604104598 0.339485843584001 0.299721583762389 0.340485625322197 NA NA NA 0.383589962073304 98.9082052833041 a3972 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 15 33 2.77258872223978 NA -0.146972489708527 -0.568142979642958 0.421170489934431 1.43764082829663 1.38969444751397 0.29988070654484 0.29295946640125 0.303066973238515 0.340578148442596 NA NA NA 0.350461650492776 98.9082052833041 a3973 loss_cnaBRCA33 37 Crizotinib MET, ALK 5 9 0.693147180559945 NA 2.92765580073476 2.49931286088885 0.42834293984591 0.533410777665491 0.86943089035219 0.553550311183826 0.803026406254073 0.492670486635684 0.340578921888395 NA NA NA 0.276555883275414 98.9082052833041 a3974 BRCA1_mut 306 TG101348 JAK2 4 44 2.32630161961136 NA 3.81472640035158 3.17126734359399 0.643459056757589 1.28559416362191 1.27966446860787 0.502681956761129 0.500514917510801 0.502834197981287 0.340799952946417 NA NA NA 0.398111831545965 98.9082052833041 a3975 loss_cnaBRCA34 291 KIN001-266 MAP3K8 (COT) 5 44 2.99573227355399 NA 3.29858657532127 3.83318529914819 -0.534598723826925 0.738445206985098 1.2098701664296 0.454157329710394 0.723951782434296 0.441864539403064 0.3408138664315 NA NA NA 0.200906372860475 98.9082052833041 a3976 gain_cnaBRCA30_(CRNKL1,FOXA2) 1022 AZD7762 CHEK1, CHEK2 5 40 0.693147180559945 NA 1.56194810558168 0.82260100812301 0.739347097458666 1.99522465581021 1.57480678344189 0.456801940984957 0.370558320490701 0.469484323557938 0.340920639310489 NA NA NA 0.463644818494674 98.9082052833041 a3977 loss_cnaBRCA33 272 AR-42 HDAC 6 43 1.63315443905142 NA -0.419668445711937 0.220336583008912 -0.64000502872085 1.16452304521966 1.56396575682294 0.419277209263548 0.549585541778719 0.409219336119586 0.340931188412887 NA NA NA 0.26422631480503 98.9082052833041 a3978 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1 Erlotinib EGFR 4 8 0.693147180559945 NA 3.15623762374134 2.81174007997422 0.344497543767113 0.316774921553889 0.63969142160036 0.612303434731011 1.08751520504602 0.538537069803531 0.340945048731037 NA NA NA 0.240685915848644 98.9082052833041 a3979 PIK3CA_mut 94 TGX221 PI3Kbeta 4 10 2.30258509299405 NA 4.29954737526139 3.55701685645227 0.742530518809122 1.04461931432042 1.33127270892092 0.586651226146146 0.710814464781533 0.55775988934002 0.340956823062737 NA NA NA 0.304165620722043 98.9082052833041 a3980 loss_cnaBRCA36_(FAT1,IRF2) 275 I-BET BRD2, BRD3, BRD4 9 40 2.99573227355399 NA 4.43177520429652 3.95055337671472 0.481221827581806 1.45601098366101 1.33467114786786 0.354859358483582 0.330507003712167 0.360554604293768 0.341045245422671 NA NA NA 0.382302749754342 98.9082052833041 a3981 gain_cnaBRCA12_(TERT) 1005 Cisplatin DNA crosslinker 10 35 1.79175946922805 2.30258509299405 3.35337530568182 3.76057162184453 -0.407196316162715 1.09292827677685 1.20148882155155 0.345200433828398 0.372573685588571 0.338909783311075 0.341071978355214 NA NA NA 0.325042656102486 98.9082052833041 a3982 BRCA2_mut 274 PXD101, Belinostat HDAC 6 42 2.99573227355399 NA 1.21967025752741 0.593193787171361 0.626476470356051 1.52892455520362 1.48759017369521 0.419851419383424 0.409749760525377 0.421135122719901 0.341079253479652 NA NA NA 0.380227170240324 98.9082052833041 a3983 gain_cnaBRCA13_(FGFR1,WHSC1L1) 196 Phenformin AAPK1 (AMPK) agonist 10 38 8.29404964010203 NA 7.69113884582176 7.07329577832115 0.617843067500605 1.98916538548421 1.76013810185935 0.341872384422563 0.310604171985533 0.351019653996432 0.341123367251333 NA NA NA 0.38742744838166 98.9082052833041 a3984 loss_cnaBRCA33 35 NVP-TAE684 ALK 5 9 0.693147180559945 NA 1.34453860957081 2.01109017237176 -0.666551562800949 1.0791779495198 1.26443917153121 0.552763942676769 0.617647500208419 0.527151940408308 0.341239157586307 NA NA NA 0.323638934152568 98.9082052833041 a3985 NF1_mut 1239 YK 4-279 RNA helicase A 5 37 2.30258509299405 NA 2.535331908662 1.94304220062063 0.592289708041371 1.20935408151758 1.29974677186986 0.458786382896927 0.489757067093306 0.45569623318955 0.341393369664259 NA NA NA 0.352399973167714 98.9082052833041 a3986 gain_cnaBRCA19 152 CP466722 ATM 4 45 2.77258872223978 NA 2.24257136325398 2.7734813515593 -0.53090998830532 0.81165268071033 1.07365022036629 0.501395055600681 0.654109819289559 0.494490643446424 0.341475947661891 NA NA NA 0.290509672076846 98.9082052833041 a3987 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 6 39 -0.669430653942629 NA -4.3723361881328 -3.3498615366998 -1.022474651433 1.15993311728909 2.54489279870252 0.421666909837884 0.881494489805282 0.401775136443584 0.341652631443807 NA NA NA 0.123781306436617 98.9082052833041 a3988 gain_cnaBRCA64_(SDHC) 329 QL-XI-92 DDR1 8 40 2.32630161961136 NA 3.96049827147572 4.31190246353604 -0.351404192060318 1.20482632219347 0.889641998740866 0.372086663623629 0.291663773929309 0.39499505706528 0.341714128984039 NA NA NA 0.454475673027895 98.9082052833041 a3989 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 192 LFM-A13 BTK 15 33 2.77258872223978 NA 4.62382385236565 4.87349115694217 -0.249667304576517 0.784058509038954 0.856044830132155 0.299076779958103 0.318429430582346 0.291652137584867 0.341861388634549 NA NA NA 0.32868931386948 98.9082052833041 a3990 loss_cnaBRCA33 170 Shikonin unknown 6 41 2.77258872223978 NA -0.429983650044537 0.0670604447431623 -0.4970440947877 0.791842822969841 1.22398704383312 0.419876218139618 0.627705499588308 0.406086075250539 0.341889590971264 NA NA NA 0.218408860167122 98.9082052833041 a3991 gain_cnaBRCA27_(CLTC,PPM1D) 1129 PF-4708671 RPS6KB1 (p70S6KA) 9 34 2.30258509299405 NA 3.48357056973411 3.89510125224385 -0.411530682509738 0.973294762458017 1.17909576138627 0.360405108138512 0.422822251165139 0.349022272818537 0.341972411014999 NA NA NA 0.298855420645545 98.9082052833041 a3992 gain_cnaBRCA61_(NOTCH2) 154 CHIR-99021 GSK3B 3 44 0.940007258491471 NA 3.76029454315219 3.2423783808088 0.517916162343389 0.274409994089131 0.922682925640108 0.573043398864089 1.88738082977825 0.561315429115681 0.34201541569335 NA NA NA 0.0486719238729882 98.9082052833041 a3993 loss_cnaBRCA29_(MAP2K4) 1129 PF-4708671 RPS6KB1 (p70S6KA) 7 36 2.30258509299405 NA 3.42933973678354 3.8827833207337 -0.453443583950158 1.2806812645009 1.11632788444726 0.39711024381092 0.354064353496163 0.406192114581708 0.342016699801208 NA NA NA 0.407777480721217 98.9082052833041 a3994 loss_cnaBRCA22_(SYNCRIP,ZNF292) 305 TPCA-1 IKK 19 30 2.99573227355399 NA 4.4157274890155 4.02797232086582 0.387755168149678 1.40125449795332 1.36303945934591 0.281430613002411 0.276720016753585 0.284478314615889 0.342034668639887 NA NA NA 0.346268858984742 98.9082052833041 a3995 gain_cnaBRCA13_(FGFR1,WHSC1L1) 223 ZSTK474 PI3K 11 38 1.63315443905142 2.32630161961136 0.544323984272303 1.01886832311312 -0.47454433884082 1.12760877438888 1.51865355146317 0.328552968071257 0.420841296750289 0.312477021756288 0.342161511470458 NA NA NA 0.270743811146818 98.9082052833041 a3996 loss_cnaBRCA18 164 JQ12 HDAC 15 32 1.63315443905142 NA 1.24300102268486 1.73485917847449 -0.491858155789636 1.68673927635403 1.61475021711336 0.300373961461083 0.291602954104923 0.304603244871468 0.342226211892661 NA NA NA 0.353443012279094 98.9082052833041 a3997 loss_cnaBRCA17 119 Lapatinib ERBB2, EGFR 3 10 0.693147180559945 NA 2.56068252010868 1.10669651202597 1.45398600808271 0.888644629523706 2.42489409964217 0.653215979489338 1.63618386898035 0.599608044036754 0.342374698835536 NA NA NA 0.146375116432881 98.9082052833041 a3998 ARID1A_mut 303 PIK-93 PI4K, PI3K 5 44 2.99573227355399 NA 2.2150104081475 2.85704047143123 -0.642030063283733 2.04718852883566 1.34536654907154 0.452555214322321 0.313615504503089 0.477215717699246 0.342503428681604 NA NA NA 0.527920124962206 98.9082052833041 a3999 loss_cnaBRCA7_(FAS,PTEN) 306 TG101348 JAK2 4 44 2.32630161961136 NA 2.63711946737726 3.27832251931893 -0.641203051941668 1.15482603991762 1.28843048387256 0.500884216126459 0.555237784547538 0.497662124552067 0.342512486455216 NA NA NA 0.356160198465588 98.9082052833041 a4000 gain_cnaBRCA61_(NOTCH2) 290 KIN001-260 IKK 3 46 2.99573227355399 NA 5.60167093229111 5.00770859388465 0.593962338406463 0.570399893575564 1.05555936282116 0.571371916534647 1.04130864170257 0.56269913311081 0.34253037399815 NA NA NA 0.201863984034792 98.9082052833041 a4001 loss_cnaBRCA17 254 AC220 FLT3 10 38 0.0237165266173161 NA 1.98605339572164 2.28631676601197 -0.300263370290331 1.27904775418464 0.753296630292921 0.340744128951834 0.234755402453086 0.398599115163403 0.342703417891427 NA NA NA 0.492513641299945 98.9082052833041 a4002 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 294 MPS-1-IN-1 MPS1 6 43 2.99573227355399 NA 4.32799234673916 4.81631193870512 -0.488319591965966 1.54800030354309 1.11617417402007 0.417468713712798 0.315451870938456 0.437494078730749 0.342997770652272 NA NA NA 0.484984302631924 98.9082052833041 a4003 gain_cnaBRCA48 140 Vinorelbine Microtubules 5 42 -2.74887219562247 NA -4.26519725297642 -3.5206051946279 -0.744592058348519 0.848683090320625 1.70005963687281 0.453369421976886 0.87734993997255 0.437979963878305 0.343019502498803 NA NA NA 0.142814967384273 98.9082052833041 a4004 gain_cnaBRCA14_(RAD21) 153 Midostaurin KIT 21 26 -0.669430653942629 NA 0.838003687894086 0.429791291849006 0.40821239604508 1.41279870341995 1.48278951263079 0.281118840336322 0.288938824092154 0.275300298908119 0.34310267174317 NA NA NA 0.340740974671957 98.9082052833041 a4005 loss_cnaBRCA33 194 AUY922 HSP90 6 41 -1.36257783450257 NA -3.02314510861962 -2.30164004547533 -0.721505063144287 0.994673527613207 1.79388559069225 0.418631671084108 0.725368719599477 0.402202385084025 0.343307996196294 NA NA NA 0.172634015096708 98.9082052833041 a4006 gain_cnaBRCA48 226 GSK1070916 AURKB 5 44 0.940007258491471 2.32630161961136 3.19220465112083 2.3143730567193 0.877831594401528 0.704206524410578 2.02047063006793 0.451682555716487 1.24655419109653 0.434468871429235 0.343426040379959 NA NA NA 0.0650734019302076 98.9082052833041 a4007 TP53_mut 211 TL-2-105 CRAF 38 11 2.32630161961136 1.63315443905142 3.98740993431569 3.63168687140619 0.355723062909493 1.10311960164838 1.01949491641784 0.32759370623228 0.322470077023326 0.348920879526679 0.343559170093369 NA NA NA 0.330973667472063 98.9082052833041 a4008 loss_cnaBRCA33 205 BMS-708163 g-secretase 6 42 2.32630161961136 0.940007258491471 4.64894887006167 4.93189818155647 -0.282949311494799 0.449583131398459 0.700195133458416 0.417661694623827 0.629359270252569 0.40410065419514 0.343578500781011 NA NA NA 0.216936477780473 98.9082052833041 a4009 PIK3CA_mut 38 AZD-0530 SRC, ABL1 4 10 0.693147180559945 NA 2.8563808678283 2.47852163082965 0.377859236998646 0.421142804312635 0.707456368770585 0.583250021745345 0.897223538261245 0.534109598384545 0.343657120115053 NA NA NA 0.248196890467232 98.9082052833041 a4010 ASH1L_mut 309 Y-39983 ROCK 3 46 2.99573227355399 NA 4.35682871635756 4.97268650622351 -0.615857789865948 0.689948935106356 1.09509016920699 0.569738655763246 0.892613581280494 0.562380895366745 0.343898627695261 NA NA NA 0.256548099791977 98.9082052833041 a4011 loss_cnaBRCA29_(MAP2K4) 265 Tubastatin A HDAC6 7 42 2.99573227355399 NA 4.34629781078936 4.74933644040474 -0.403038629615374 1.08458119069356 1.02492715420157 0.390263567171862 0.371607615062585 0.393236366080423 0.343990575281479 NA NA NA 0.386162102497352 98.9082052833041 a4012 gain_cnaBRCA14_(RAD21) 127 GSK269962A ROCK1, ROCK2 6 8 0.916290731874155 NA 2.13493060008627 2.71793298704822 -0.583002386961951 1.53722470340312 0.609460189144316 0.53192174248457 0.379256452014657 0.956588137086506 0.344102353028208 NA NA NA 0.412417916338192 98.9082052833041 a4013 gain_cnaBRCA62 1001 AICAR AAPK1 (AMPK) agonist 8 37 7.60090245954208 NA 8.16071826957616 7.64718924729401 0.513529022282152 1.62279037336875 1.32441035761398 0.3728260961386 0.316448156650152 0.387741623530726 0.344319562936054 NA NA NA 0.424067828687041 98.9082052833041 a4014 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1030 KU-55933 ATM 8 34 2.30258509299405 NA 4.50230541884069 4.15641557533193 0.345889843508753 0.602121974493811 0.974031417387153 0.376021737129866 0.57445145362704 0.35511158812167 0.344358945120578 NA NA NA 0.21842645327934 98.9082052833041 a4015 POLR2B_mut 1114 Cetuximab EGFR 3 42 4.18661983833127 NA 6.74948816548336 6.2492348329652 0.500253332518154 0.674920259057735 0.884220736084424 0.571328988348195 0.741203610062861 0.565756164838901 0.344408201707229 NA NA NA 0.326988113300651 98.9082052833041 a4016 gain_cnaBRCA8_(CHD4,WNK1) 294 MPS-1-IN-1 MPS1 4 45 2.99573227355399 NA 4.22117354816833 4.80410385004626 -0.58293030187793 1.36848719841039 1.15498922416475 0.49832407184752 0.425966938203771 0.504706268839421 0.344412639337945 NA NA NA 0.462836915770001 98.9082052833041 a4017 TP53_mut 190 Bleomycin DNA damage 38 10 4.15888308335967 NA 2.27198881022617 1.34275847152177 0.929230338704395 2.81588553324035 2.38742093775241 0.339464991489177 0.329995778498529 0.389219313615972 0.344500604706757 NA NA NA 0.307704881928845 98.9082052833041 a4018 PTEN_mut 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 8 38 2.30258509299405 NA 1.10832570251083 1.47735369692197 -0.369027994411145 0.890045628767194 1.01106403308338 0.371704885168235 0.414616939271177 0.364989735898073 0.344517389202218 NA NA NA 0.320369637771427 98.9082052833041 a4019 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1059 AZD8055 MTORC1/2 15 28 0.693147180559945 NA 0.33070169010197 0.0231427212639069 0.307558968838063 1.00160624372605 1.00696786164655 0.305986114269239 0.307065746409407 0.305430769493631 0.344527939819985 NA NA NA 0.346076188660422 98.9082052833041 a4020 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1161 ZG-10 IRAK1 5 21 2.30258509299405 NA 2.51601401330382 1.84669549768219 0.669318515621638 1.94271717250705 1.25792198651777 0.479596201401438 0.344526998110533 0.532082690973922 0.344761176702298 NA NA NA 0.496684808321994 98.9082052833041 a4021 gain_cnaBRCA48 276 CAY10603 HDAC6 5 44 2.99573227355399 NA 1.57575014034629 1.13006129142092 0.445688848925375 1.31753622787114 0.953391646999175 0.450366778499892 0.338274454620131 0.467477190856656 0.344820230865827 NA NA NA 0.498985212581066 98.9082052833041 a4022 loss_cnaBRCA33 11 Paclitaxel Microtubules 4 8 -2.27886856637673 NA -2.38021790552037 -3.45119739933553 1.07097949381517 1.22498030703086 1.9500947514019 0.607083854431103 0.874283029423579 0.549193567669085 0.344889234736753 NA NA NA 0.274968768370657 98.9082052833041 a4023 gain_cnaBRCA62 1026 17-AAG HSP90 7 36 0 NA -0.307357642601199 -1.01070506837509 0.703347425773889 1.35583244811789 1.84507153535898 0.394720810979933 0.518756891200124 0.381203336724309 0.344897193523183 NA NA NA 0.26440222828792 98.9082052833041 a4024 BRCA2_mut 1025 SB 216763 GSK3A, GSK3B 5 34 2.30258509299405 NA 4.57575972030091 4.93524980573608 -0.359490085435167 0.868860347261924 0.77364571484424 0.458243061184852 0.413748983444858 0.464670169481317 0.344914858066703 NA NA NA 0.421504225012033 98.9082052833041 a4025 gain_cnaBRCA58_(CCND1) 1494 SN-38 TOP1 9 39 -2.99573227355399 NA -2.82219107468032 -3.41492637959511 0.592735304914795 0.933145882903247 1.79783968531326 0.352872540101057 0.635201114610986 0.329693080955389 0.344957536674842 NA NA NA 0.174803216420991 98.9082052833041 a4026 loss_cnaBRCA60 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 3 45 0.246860077931526 2.32630161961136 -1.14493095723212 -0.206286598972127 -0.938644358259997 0.837705325322259 1.67726437554732 0.568988975632677 1.12049467740808 0.559628149231811 0.344958291055207 NA NA NA 0.177385607866417 98.9082052833041 a4027 MACF1_mut 1268 XAV 939 TNKS1 (tankyrase-1) 3 44 1.6094379124341 NA 3.16187447648753 3.69550415458218 -0.533629678094655 0.175795516251421 0.957908999447934 0.569439851178382 3.03551358688502 0.557077633055121 0.345029180956923 NA NA NA 0.00837396914948823 98.9082052833041 a4028 loss_cnaBRCA57 1019 Bosutinib SRC, ABL, TEC 5 40 0.693147180559945 NA 3.03772480468435 2.61570775388819 0.422017050796164 0.767225004715891 0.947117660137989 0.452881069225378 0.55005643481659 0.445580384104209 0.345037409653857 NA NA NA 0.305227057243533 98.9082052833041 a4029 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1166 QL-VIII-58 MTOR, ATR 13 13 2.30258509299405 NA -1.73000088975108 -1.3080532572599 -0.42194763249118 1.25088729386182 0.96441339955128 0.377793620736029 0.337318665367939 0.437517389002997 0.345058128046489 NA NA NA 0.345672767241442 98.9082052833041 a4030 gain_cnaBRCA47_(EGFR) 1149 TW 37 BCL2, BCL2L1 7 36 1.6094379124341 NA -0.553183845261363 -0.062506541733638 -0.490677303527725 0.897649221687834 1.29397473232607 0.394470446238768 0.546624774658762 0.379201611337243 0.345199937685086 NA NA NA 0.246688739834064 98.9082052833041 a4031 loss_cnaBRCA17 135 Gemcitabine DNA replication 10 37 0.0237165266173161 NA -1.01313239316026 -0.075788955835896 -0.937343437324364 2.13691369414249 2.89140651636387 0.339977427366876 0.438643563328609 0.324182515332757 0.345231398582273 NA NA NA 0.270717849128195 98.9082052833041 a4032 gain_cnaBRCA58_(CCND1) 166 FTI-277 Farnesyl transferase (FNTA) 9 38 0.0237165266173161 NA 2.47686524791759 2.18932749544188 0.287537752475705 0.646807931410375 0.84486987535837 0.353591362526946 0.44454889699439 0.340333773119487 0.345271257413161 NA NA NA 0.277800862674103 98.9082052833041 a4033 ASH1L_mut 235 QL-XII-47 BTK, BMX 3 46 2.32630161961136 NA 2.50849159117553 1.65587401897139 0.852617572204137 0.985551450604234 1.51975390303867 0.56807081348914 0.865117261692836 0.561023446295725 0.34529956375971 NA NA NA 0.268111734152847 98.9082052833041 a4034 gain_cnaBRCA10_(MDM2,NUP107) 281 CH5424802 ALK 5 43 1.63315443905142 NA 4.00411380070598 3.52537053597072 0.478743264735251 1.01779116246435 1.06677746504636 0.45053633873437 0.470374751118966 0.448775194847638 0.345312133498305 NA NA NA 0.366770137061004 98.9082052833041 a4035 gain_cnaBRCA63 256 JW-7-24-1 LCK 7 41 2.32630161961136 NA 1.45079123073536 1.90360437950139 -0.452813148766033 0.603370728183534 1.22315577595926 0.389943304113802 0.75047251650613 0.370200719864086 0.345319436856875 NA NA NA 0.147281856797981 98.9082052833041 a4036 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 273 CUDC-101 HDAC, EGFR 6 43 1.63315443905142 NA -0.597267053925265 0.0529726807002553 -0.65023973462552 0.752719816074777 1.63529390249908 0.415425176031519 0.863853615567526 0.397628667013197 0.345342860150563 NA NA NA 0.124186544977112 98.9082052833041 a4037 gain_cnaBRCA30_(CRNKL1,FOXA2) 261 TL-1-85 MAP3K7 (TAK1) 5 44 2.32630161961136 NA 4.51313847494967 3.96931419219191 0.543824282757763 1.56430193614544 1.17083073476583 0.449697214758854 0.347646621276828 0.464477286604994 0.345531125673429 NA NA NA 0.48835055312328 98.9082052833041 a4038 loss_cnaBRCA60 263 FR-180204 ERK 3 46 2.99573227355399 NA 5.74782564160155 5.33245397074591 0.415371670855638 0.515669290324799 0.739686105685392 0.567794946036488 0.805500111503659 0.561551268386684 0.345531645382856 NA NA NA 0.294952243208857 98.9082052833041 a4039 POLR2B_mut 1259 BMN-673 PARP1 3 43 2.30258509299405 NA 2.47876117856599 3.36322014714292 -0.884458968576923 4.10122974914496 1.31408835330685 0.569389359505925 0.215657015742978 0.673058981423296 0.345540877229672 NA NA NA 0.745034810880808 98.9082052833041 a4040 MACF1_mut 1026 17-AAG HSP90 3 40 0 NA -1.84292094260393 -0.825203078297495 -1.01771786430644 1.68802982322231 1.78662845533641 0.571127429640418 0.602902774764785 0.569630390284369 0.345629602468864 NA NA NA 0.407762391493585 98.9082052833041 a4041 NF1_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 41 1.38629436111989 NA 3.45297379627956 2.78612576197992 0.666848034299637 1.34284862647992 1.49072798043463 0.451214460866369 0.496592111091241 0.447330460722427 0.346029279110577 NA NA NA 0.345576591163757 98.9082052833041 a4042 loss_cnaBRCA38 283 GSK2126458 PI3K, MTOR 4 44 -2.05572501506252 0.0237165266173161 -3.79806998864093 -2.98783862358582 -0.810231365055107 1.13314950903625 1.65962328682464 0.496928694249009 0.715026003712617 0.488201974199412 0.346300502184901 NA NA NA 0.2567528838496 98.9082052833041 a4043 MLL3_mut 1529 MLN4924 NEDD8-activating enzyme 3 34 0 NA -0.525865832113854 0.448193016861222 -0.974058848975076 1.65878792936927 1.69652734240383 0.574871703924152 0.58721119905029 0.574148629750299 0.346383274903405 NA NA NA 0.418571759935196 98.9082052833041 a4044 loss_cnaBRCA24 1091 BMS-536924 IGF1R 3 44 1.38629436111989 NA 3.60378928604255 2.98372355554574 0.62006573049681 0.826908299656155 1.10280880269895 0.56781133471793 0.749860330044631 0.562260410852087 0.346396888864952 NA NA NA 0.322432985815358 98.9082052833041 a4045 loss_cnaBRCA7_(FAS,PTEN) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 4 44 2.32630161961136 NA 4.64227967109774 4.98723683369349 -0.344957162595748 0.706877029922403 0.693455387786676 0.496814021781099 0.488001657987975 0.497446798555794 0.346410728131932 NA NA NA 0.40856258183071 98.9082052833041 a4046 gain_cnaBRCA16 268 YM155 BIRC5 (Survivin) 16 33 1.63315443905142 NA -3.90673198992413 -3.44471546236599 -0.462016527558143 1.50786776024387 1.63406502379081 0.28968831573025 0.306403876878049 0.282740601402952 0.34650310692988 NA NA NA 0.335231623351334 98.9082052833041 a4047 CDH1_mut 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 4 39 1.6094379124341 NA 3.51358283679163 2.80174112104135 0.711841715750277 1.85496776587335 1.38395945013579 0.499988195433214 0.38374883318532 0.514351569824126 0.346510128589233 NA NA NA 0.504297878143419 98.9082052833041 a4048 gain_cnaBRCA13_(FGFR1,WHSC1L1) 201 Epothilone B Microtubules 10 38 -3.44201937618241 NA -3.75393647455518 -4.36255304325146 0.608616568696279 2.44855595420481 1.60390853508354 0.338004478839946 0.248561429707631 0.379458401388568 0.346560204686545 NA NA NA 0.47168823165551 98.9082052833041 a4049 loss_cnaBRCA57 185 OSI-906 IGF1R 5 43 0.940007258491471 NA 3.34651092089194 2.84081305116699 0.505697869724942 0.954863672141437 1.14036857991247 0.449328617654608 0.529602166758353 0.443451247809508 0.34659423292496 NA NA NA 0.319044289376901 98.9082052833041 a4050 loss_cnaBRCA24 238 CAL-101 PI3Kdelta 3 46 2.99573227355399 2.32630161961136 4.21739749282033 4.7516750929067 -0.534277600086371 1.22240583892206 0.92912668246666 0.566292580648831 0.43707055633627 0.575032027568042 0.346797355317991 NA NA NA 0.529984622463257 98.9082052833041 a4051 gain_cnaBRCA16 1066 AZD6482 PI3Kbeta 14 29 1.6094379124341 NA 2.26683789536658 1.82252889303406 0.44430900233252 1.39623471549666 1.45254453456873 0.309638217707178 0.318219420704257 0.305883222000101 0.346954376587922 NA NA NA 0.343204465969615 98.9082052833041 a4052 TP53_mut 281 CH5424802 ALK 37 11 1.63315443905142 NA 3.49577183229101 3.84254038686396 -0.346768554572949 1.169078092154 0.523871899252686 0.326315428104685 0.296617101030467 0.661933871749223 0.346977452002256 NA NA NA 0.17139093332802 98.9082052833041 a4053 loss_cnaBRCA34 1218 JQ1 BRD2, BRD3, BRD4 5 41 0 NA 2.17684933353979 2.49226632791799 -0.315416994378203 0.917158354089016 0.674993421372596 0.45028918639219 0.343906799705812 0.467288990367942 0.347009208647676 NA NA NA 0.493087522263421 98.9082052833041 a4054 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1006 Cytarabine DNA synthesis 6 39 0.693147180559945 NA 1.75953085062128 1.12376441697439 0.635766433646892 0.920584201757873 1.58735482214943 0.416929535670197 0.690611931459267 0.400519420595582 0.347047084416716 NA NA NA 0.190441359527795 98.9082052833041 a4055 MACF1_mut 1019 Bosutinib SRC, ABL, TEC 3 42 0.693147180559945 NA 2.16843693951909 2.69789579429505 -0.529458854775956 1.41442288843838 0.9018169862558 0.568130113490127 0.374328540002994 0.587102331010846 0.347088299832929 NA NA NA 0.584959590119877 98.9082052833041 a4056 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 179 5-Fluorouracil DNA antimetabolite 6 43 3.46573590279973 NA 3.4549450940411 4.12331830582319 -0.668373211782086 2.41259602452907 1.4917221656978 0.413893235184028 0.277034864099369 0.448054756543377 0.347107762894674 NA NA NA 0.534975123986873 98.9082052833041 a4057 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 5 Sunitinib PDGFRA, PDGFRB, KDR, KIT, FLT3 3 9 2.07944154167984 NA 3.93491451909229 3.02890014863125 0.906014370461036 1.7252585157237 1.27672648523792 0.657408209727125 0.525147021274656 0.709638580335552 0.347335987393979 NA NA NA 0.468823788967282 98.9082052833041 a4058 gain_cnaBRCA27_(CLTC,PPM1D) 5 Sunitinib PDGFRA, PDGFRB, KDR, KIT, FLT3 3 9 2.07944154167984 NA 3.93491451909229 3.02890014863125 0.906014370461036 1.7252585157237 1.27672648523792 0.657408209727125 0.525147021274656 0.709638580335552 0.347335987393979 NA NA NA 0.468823788967282 98.9082052833041 a4059 loss_cnaBRCA57 225 Genentech Cpd 10 AURKA, AURKB 5 44 2.32630161961136 NA 3.66588487969668 2.94444737497743 0.721437504719256 1.4941778588015 1.62074781800082 0.447996752429179 0.482832415478255 0.445126315585075 0.347340885459984 NA NA NA 0.355978846203773 98.9082052833041 a4060 PIK3CA_mut 255 CP724714 ERBB2 16 32 2.32630161961136 NA 3.48047860967691 3.96431422299093 -0.483835613314016 1.73290434016413 1.63115628928279 0.290588760831729 0.279205032903426 0.296621247450639 0.347550326472533 NA NA NA 0.360321350620462 98.9082052833041 a4061 gain_cnaBRCA48 1069 EHT 1864 Rac GTPases 5 41 2.30258509299405 NA 3.90486673178161 3.51953815138965 0.385328580391964 0.851588889063197 0.857366304302791 0.449707493433813 0.452481925657638 0.449432848548104 0.347626196017278 NA NA NA 0.383314945671015 98.9082052833041 a4062 gain_cnaBRCA58_(CCND1) 1010 Gefitinib EGFR 9 36 -0.693147180559945 NA 1.10570672923371 1.47344558603994 -0.36773885680623 1.14885283031097 1.01258758595238 0.353835625767612 0.320092223393566 0.363167455248185 0.347702523033081 NA NA NA 0.39782961212801 98.9082052833041 a4063 loss_cnaBRCA28_(GPS2) 293 MP470 PDGFR 4 44 2.99573227355399 NA 2.77498319748013 3.6003671734706 -0.825383975990467 1.83563571082529 1.65358676624002 0.495408933774274 0.449644758555814 0.499147666661154 0.347763206123483 NA NA NA 0.441537387703469 98.9082052833041 a4064 TP53_mut 1013 Nilotinib ABL 31 9 0.693147180559945 NA 3.28026745993896 2.93644489312386 0.343822566815093 0.894885345870535 1.1535490455966 0.359955883521849 0.384208511628522 0.298056305562 0.347788852527127 NA NA NA 0.426979574716467 98.9082052833041 a4065 gain_cnaBRCA47_(EGFR) 154 CHIR-99021 GSK3B 7 40 0.940007258491471 NA 2.97642631874329 3.32776370384602 -0.351337385102728 0.951424860986158 0.896504615664984 0.388638904717393 0.369274968008051 0.391896906009929 0.347898260031864 NA NA NA 0.390006677510476 98.9082052833041 a4066 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 173 FH535 unknown 9 39 3.46573590279973 NA 1.93693921520925 1.48901165211758 0.447927563091667 1.21875302457292 1.28945009534576 0.35064578539952 0.367529396079762 0.347378750607295 0.347980870672228 NA NA NA 0.344302474465815 98.9082052833041 a4067 loss_cnaBRCA7_(FAS,PTEN) 1058 GDC0941 PI3K (class 1) 4 39 1.38629436111989 0.693147180559945 1.9712488706106 1.28187474379517 0.689374126815433 1.14453836026571 1.40033069994796 0.498383908836267 0.602316314374462 0.492293803771533 0.348042952923456 NA NA NA 0.325036216618407 98.9082052833041 a4068 BRCA2_mut 196 Phenformin AAPK1 (AMPK) agonist 6 42 8.29404964010203 NA 7.85648099018903 7.10851766888779 0.747963321301233 1.63073370056938 1.82815819041303 0.413755175164083 0.458666746777894 0.409134901576679 0.348067139612426 NA NA NA 0.335664519399598 98.9082052833041 a4069 loss_cnaBRCA60 173 FH535 unknown 3 45 3.46573590279973 NA 0.896171396243033 1.61811984846088 -0.721948452217851 1.28181697799641 1.2772478608187 0.565149499366393 0.5632227257173 0.565237550490076 0.348191889452696 NA NA NA 0.434039304067348 98.9082052833041 a4070 POLR2B_mut 219 AT-7519 CDK9 3 46 2.32630161961136 NA 0.713627481849216 1.7345030917261 -1.02087560987689 2.32894682565743 1.78169000869939 0.564532913344932 0.438342171933748 0.5729816100962 0.348283705188818 NA NA NA 0.528937381269806 98.9082052833041 a4071 loss_cnaBRCA33 60 BI-2536 PLK1, PLK2, PLK3 4 8 -1.36257783450257 NA -0.872547945151027 -1.81050993988265 0.937961994731627 1.64591385174488 1.51655984632528 0.60261154978119 0.56987307916345 0.618480040207032 0.348295405071484 NA NA NA 0.378649784289 98.9082052833041 a4072 CDH1_mut 156 AZD6482 PI3Kbeta 4 43 1.63315443905142 NA 1.39228397492834 2.11480057655455 -0.722516601626201 1.4445629950881 1.45968692761205 0.495321006832038 0.500162751007018 0.494980524904878 0.348419578238692 NA NA NA 0.398865974248737 98.9082052833041 a4073 loss_cnaBRCA20 1030 KU-55933 ATM 3 39 2.30258509299405 NA 4.70784018527729 4.18495006041486 0.522890124862427 0.737824092812066 0.928646036213615 0.568330795862635 0.70869212588266 0.56306720157275 0.348535277755254 NA NA NA 0.344625295036946 98.9082052833041 a4074 gain_cnaBRCA48 253 XMD14-99 EPHB3, CAMK1 5 43 2.32630161961136 NA 5.24236394167455 4.89714113075186 0.345222810922692 0.401979738614277 0.79779582726329 0.447480479317684 0.858806496349193 0.43272075276067 0.348562242950056 NA NA NA 0.148890515594201 98.9082052833041 a4075 gain_cnaBRCA19 206 Ruxolitinib JAK1, JAK2, TYK2 4 45 1.65632149833295 0.0237165266173161 4.07449761328989 4.39655048246789 -0.322052869177999 0.530300393220644 0.659572242934864 0.493880229161839 0.607302716149413 0.488275352135768 0.348691519589222 NA NA NA 0.320217425410139 98.9082052833041 a4076 gain_cnaBRCA19 266 Zibotentan, ZD4054 Endothelin A Receptor 4 45 2.99573227355399 NA 5.51914577351368 5.76185214992426 -0.242706376410587 0.37228268903422 0.498538119010178 0.49385840172049 0.651941074779004 0.486836145834683 0.348712622447099 NA NA NA 0.292177968983806 98.9082052833041 a4077 gain_cnaBRCA63 119 Lapatinib ERBB2, EGFR 3 10 0.693147180559945 NA 0.337783535789003 1.77356620732188 -1.43578267153288 2.68434887021579 2.11372015193863 0.64432079932225 0.534871859415747 0.679268099997071 0.348718268075664 NA NA NA 0.461670403318755 98.9082052833041 a4078 BRCA1_mut 190 Bleomycin DNA damage 4 44 4.15888308335967 NA 0.837749138040601 2.1911855216284 -1.3534363835878 3.33639665425881 2.69108533943375 0.494349791806808 0.405658116777026 0.502933282625882 0.348784980735709 NA NA NA 0.482296293853928 98.9082052833041 a4079 POLR2B_mut 292 Masitinib KIT 3 45 2.99573227355399 NA 3.43505641447126 4.04867877918501 -0.613622364713751 0.87565593159478 1.09589819619003 0.564379910429767 0.700757389487668 0.559926430070833 0.348842422416493 NA NA NA 0.348688564964742 98.9082052833041 a4080 gain_cnaBRCA13_(FGFR1,WHSC1L1) 272 AR-42 HDAC 11 38 1.63315443905142 NA 0.525559181771496 0.0309292472532937 0.494629934518202 2.11979499976537 1.32181702012581 0.323936789917111 0.233338570273517 0.374204543433041 0.348921820580873 NA NA NA 0.476841979595097 98.9082052833041 a4081 gain_cnaBRCA15 1143 HG-5-88-01 EGFR, ADCK4 14 12 2.30258509299405 NA 4.70305487458818 4.33693624890208 0.366118625686096 0.945689858871828 1.0069222844431 0.375802079755605 0.387144498010015 0.36360167149204 0.348963868372335 NA NA NA 0.351805238871753 98.9082052833041 a4082 MLL3_mut 1021 Axitinib PDGFR, KIT, VEGFR 3 42 0.693147180559945 NA 1.84574647036532 2.50639510278413 -0.660648632418807 0.351801656231584 1.19339727353899 0.565730038488625 1.87790085895422 0.553586510600675 0.349108140929849 NA NA NA 0.0498812166135576 98.9082052833041 a4083 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1175 AG-014699 PARP1, PARP2 13 30 1.6094379124341 NA 4.0862621400047 3.76420433559056 0.322057804414142 1.10035794217751 0.990750682230004 0.314495472089433 0.29268458205229 0.325064428610079 0.349118494935867 NA NA NA 0.374353357318183 98.9082052833041 a4084 ASH1L_mut 295 NVP-BHG712 EPHB4 3 46 2.32630161961136 NA 3.2381292268721 3.92900688440119 -0.690877657529086 1.06931189710681 1.23301020218145 0.56329684700981 0.646095549295172 0.560317875964677 0.349330276851555 NA NA NA 0.38038156987332 98.9082052833041 a4085 loss_cnaBRCA42 176 IPA-3 PAK1, PAK2, PAK3 3 44 3.46573590279973 NA 5.29260481649006 4.4425827204705 0.850022096019567 0.487120109644762 1.53729336913432 0.564330815420785 1.74499487742244 0.552934210923078 0.349331946683647 NA NA NA 0.0621458114788837 98.9082052833041 a4086 gain_cnaBRCA15 11 Paclitaxel Microtubules 6 6 -2.27886856637673 NA -3.5944009193133 -2.59400755014765 -1.00039336916565 2.1653360495658 1.24376156772852 0.566559955887618 0.462003747347327 0.80432889640791 0.349584323917213 NA NA NA 0.355266420209894 98.9082052833041 a4087 loss_cnaBRCA38 1199 Tamoxifen ER 3 44 1.6094379124341 NA 3.36721713132697 3.90339429667741 -0.536177165350439 0.884520457061056 0.954097221098941 0.563736551180306 0.606178365995021 0.561973301560258 0.349834705378857 NA NA NA 0.405449339042541 98.9082052833041 a4088 loss_cnaBRCA18 1259 BMN-673 PARP1 15 31 2.30258509299405 NA 3.61671247167244 3.154969767347 0.461742704325444 1.31246511821368 1.65418219968596 0.297202830815547 0.351813315201774 0.279136545184143 0.349853971012806 NA NA NA 0.312735429207292 98.9082052833041 a4089 gain_cnaBRCA31 3 Rapamycin MTOR 4 10 -2.30258509299405 NA -1.6623207804791 -3.17420067613036 1.51187989565126 1.04021163360258 2.97405648307473 0.575384871745402 1.45343490383312 0.508356147321118 0.349960378403899 NA NA NA 0.18489487544965 98.9082052833041 a4090 loss_cnaBRCA36_(FAT1,IRF2) 3 Rapamycin MTOR 3 11 -2.30258509299405 NA -1.43453410140589 -3.09888068900021 1.66434658759432 1.89944872181592 2.75021485182308 0.633404651315998 0.87622612207355 0.605169660287103 0.350014045139059 NA NA NA 0.28412416002063 98.9082052833041 a4091 PIK3CA_mut 110 Roscovitine CDKs 4 9 2.77258872223978 NA 4.49146675479642 3.89716050513389 0.594306249662533 0.906914988485863 1.05051703291014 0.586463487333784 0.655305356298891 0.565727380941349 0.350071439275767 NA NA NA 0.335336186869876 98.9082052833041 a4092 loss_cnaBRCA28_(GPS2) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 3 40 -1.38629436111989 0.693147180559945 -1.72037689868728 -2.25802121905425 0.537644320366969 0.988582736342088 0.948243585327746 0.565791854631585 0.543853640775013 0.566989672997514 0.350105742099806 NA NA NA 0.447925015050156 98.9082052833041 a4093 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 192 LFM-A13 BTK 6 42 2.77258872223978 NA 4.49449989164828 4.83846587177826 -0.343965980129975 0.970144380597615 0.81707765527839 0.411898048528574 0.354551329687742 0.420970978594172 0.350214445981629 NA NA NA 0.43930439668069 98.9082052833041 a4094 BRCA2_mut 253 XMD14-99 EPHB3, CAMK1 6 42 2.32630161961136 NA 4.65507263345282 4.972820298333 -0.317747664880176 0.585039144877709 0.79127626689083 0.411838681942288 0.543122058860855 0.401563497068736 0.350283231587932 NA NA NA 0.270646425883663 98.9082052833041 a4095 loss_cnaBRCA17 1006 Cytarabine DNA synthesis 8 37 0.693147180559945 NA 1.67022209589616 1.10870866482594 0.561513431070221 1.35056874033125 1.55675433630314 0.368183801719492 0.415760719393297 0.360694952296493 0.350298588681051 NA NA NA 0.321442666577926 98.9082052833041 a4096 gain_cnaBRCA63 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 6 41 2.77258872223978 NA 5.37891997667415 4.95704511797657 0.421874858697588 1.19323700015984 0.999277610818875 0.412532273754703 0.35355495902413 0.422179836844213 0.350315551424183 NA NA NA 0.440712919615606 98.9082052833041 a4097 gain_cnaBRCA58_(CCND1) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 9 38 0.940007258491471 NA 1.53494141325545 1.97243384906246 -0.43749243580701 1.38071182285058 1.22081154709145 0.349788769706528 0.316860063458989 0.358361973925725 0.350432624149259 NA NA NA 0.400976394784646 98.9082052833041 a4098 CDH1_mut 185 OSI-906 IGF1R 4 44 0.940007258491471 NA 3.40177775647632 2.84728192678943 0.554495829686884 0.282384018779461 1.16183918032968 0.492610710956744 1.96362326764653 0.477256955243619 0.350466973657638 NA NA NA 0.0249549875665771 98.9082052833041 a4099 loss_cnaBRCA7_(FAS,PTEN) 262 VX-11e ERK 4 45 1.63315443905142 NA 4.37663996944326 3.72349389795101 0.653146071492249 0.401527308452184 1.36854345029853 0.491817022697207 1.62665417206618 0.477256364311833 0.350689937271756 NA NA NA 0.0423197634726721 98.9082052833041 a4100 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 312 AV-951 VEGFR 6 42 -2.05572501506252 NA 0.862739982727633 0.599352400658167 0.263387582069466 0.472972051264247 0.657846865308976 0.411322937453907 0.556877687308235 0.400378258161584 0.35088117579558 NA NA NA 0.261474056608787 98.9082052833041 a4101 gain_cnaBRCA62 1129 PF-4708671 RPS6KB1 (p70S6KA) 7 36 2.30258509299405 NA 4.18173829904635 3.73648360029371 0.445254698752641 1.40212705382138 1.09158878430958 0.389781495773492 0.317556599124976 0.407895999988917 0.35090231791613 NA NA NA 0.451289273135377 98.9082052833041 a4102 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1494 SN-38 TOP1 8 40 -2.99573227355399 NA -2.79286383140405 -3.4059734456275 0.613109614223445 1.03359132665178 1.77139431214664 0.364913242583385 0.593183783971518 0.346116959967235 0.351011460501396 NA NA NA 0.200965583873235 98.9082052833041 a4103 loss_cnaBRCA42 333 T0901317 LXR 3 45 2.32630161961136 NA 4.33377107659307 4.76221388132548 -0.428442804732414 0.582474657376756 0.770156090210916 0.561555894256435 0.735556129878607 0.556306455507066 0.3512363883192 NA NA NA 0.329878605889417 98.9082052833041 a4104 loss_cnaBRCA38 290 KIN001-260 IKK 4 45 2.99573227355399 NA 4.5749544637764 5.08577311689915 -0.510818653122752 0.376206494004538 1.07026339971107 0.491221071724914 1.35781455467536 0.477283118586187 0.351268566715094 NA NA NA 0.0698141508074222 98.9082052833041 a4105 gain_cnaBRCA19 1019 Bosutinib SRC, ABL, TEC 4 41 0.693147180559945 NA 2.24343673183345 2.70349237199062 -0.460055640157168 1.23809832026515 0.904990531681905 0.493568119862237 0.371582476631293 0.508354092171732 0.351332318194512 NA NA NA 0.516466305524808 98.9082052833041 a4106 MLL3_mut 1001 AICAR AAPK1 (AMPK) agonist 3 42 7.60090245954208 NA 7.01444437693575 7.79020036132572 -0.77575598438997 0.436879421667425 1.40771636798059 0.563033769994937 1.77567526854244 0.551074067216263 0.351386448958616 NA NA NA 0.0592636470612289 98.9082052833041 a4107 POLR2B_mut 165 DMOG Prolyl-4-Hydroxylase 3 43 8.29404964010203 NA 6.76459712465041 7.6261701211293 -0.861572996478886 2.6494265369947 1.45744599581101 0.562427715842069 0.325192257437032 0.591152604594077 0.351411125584181 NA NA NA 0.631290986483908 98.9082052833041 a4108 gain_cnaBRCA15 286 KIN001-236 TIE2 22 27 2.32630161961136 NA 4.4260931542048 4.63300170977913 -0.206908555574329 0.774231811181276 0.758455572034791 0.270276252666567 0.267243676359204 0.272802472818854 0.351501647242641 NA NA NA 0.35277787689934 98.9082052833041 a4109 gain_cnaBRCA47_(EGFR) 207 AS601245 JNK 7 41 2.07944154167984 NA 1.84506453217623 2.33810201234122 -0.493037480164995 1.09342755556839 1.30672434344097 0.384909221926243 0.450910055864381 0.377307947647696 0.351522679156152 NA NA NA 0.312018503674436 98.9082052833041 a4110 BRCA2_mut 1046 681640 WEE1, CHEK1 5 31 0.693147180559945 NA 2.21695702357936 2.70102679650766 -0.484069772928303 1.12202127643803 1.05544909808095 0.455167786413332 0.431426554106917 0.458638672209254 0.351595523232731 NA NA NA 0.406611110911205 98.9082052833041 a4111 loss_cnaBRCA7_(FAS,PTEN) 186 Bexarotene Retinioic acid X family agonist 4 43 2.07944154167984 NA 4.11660383576879 3.55675910189974 0.559844733869048 0.634856137661694 1.16547323936361 0.492031291437878 0.88184503646932 0.480358291345021 0.351599091125683 NA NA NA 0.182880106634727 98.9082052833041 a4112 loss_cnaBRCA17 226 GSK1070916 AURKB 11 38 0.940007258491471 2.32630161961136 1.91830673269193 2.54452799188532 -0.626221259193388 1.50028806723142 2.04759866176409 0.322114245265499 0.417400679823439 0.305832031875755 0.351614858187072 NA NA NA 0.27654947982777 98.9082052833041 a4113 PIK3CA_mut 269 NSC-207895 MDM4 17 32 2.99573227355399 NA 4.82255822487275 4.48780274226305 0.334755482609698 0.932080645015809 1.29727469040401 0.282339291451984 0.359148625604194 0.258045181244879 0.351644855111975 NA NA NA 0.304412100590675 98.9082052833041 a4114 TP53_mut 230 GSK429286A ROCK2 38 11 2.99573227355399 2.32630161961136 5.47021706453716 5.18194793294058 0.288269131596581 0.848018209738792 1.05194463531425 0.321978575893709 0.33993271404558 0.274034508964881 0.351815868715818 NA NA NA 0.418400343073107 98.9082052833041 a4115 gain_cnaBRCA48 197 Bryostatin 1 PRKC 5 43 -4.8283137373023 NA -3.19080313445536 -2.76215285200164 -0.428650282453729 0.819047602372173 0.977246425148125 0.444417961940322 0.523352099697561 0.438630698893329 0.351839510928566 NA NA NA 0.324227879409889 98.9082052833041 a4116 gain_cnaBRCA13_(FGFR1,WHSC1L1) 184 BMS-754807 IGF1R 10 38 0.940007258491471 NA 2.07020898130449 1.51020052662077 0.560008454683726 1.39232281925642 1.73717618392307 0.334273559410601 0.402211647283639 0.322367103501878 0.351858194214819 NA NA NA 0.298866754402183 98.9082052833041 a4117 BRCA2_mut 229 LY317615 PRKCB (PKCbeta) 6 43 2.99573227355399 2.32630161961136 2.77933879218343 3.43940785523665 -0.660069063053215 1.26989450052355 1.64667798580019 0.409779872733607 0.519782598303309 0.400848902302208 0.351875898549415 NA NA NA 0.286774417583295 98.9082052833041 a4118 gain_cnaBRCA62 310 YM201636 FYV1 10 39 1.63315443905142 NA 2.14554314020605 2.48367372574646 -0.338130585540411 0.867846404147619 1.04690345014943 0.333112595941114 0.389620310603829 0.322981632634936 0.352136397016891 NA NA NA 0.308277221354908 98.9082052833041 a4119 gain_cnaBRCA15 1050 ZM-447439 AURKB 19 20 1.38629436111989 0.693147180559945 3.09126202043813 2.69475303962397 0.396508980814157 1.37657486041783 1.25141432326109 0.301804658540901 0.288040260079865 0.316848683480692 0.35226504509481 NA NA NA 0.353587591553873 98.9082052833041 a4120 loss_cnaBRCA23 345 KIN001-270 CDK9 3 46 2.99573227355399 NA 4.74550748016575 5.13120086913389 -0.385693388968136 0.181073448615131 0.703099658644041 0.559794750846234 2.1300383458644 0.548561479480679 0.352306664564807 NA NA NA 0.0322450693904532 98.9082052833041 a4121 gain_cnaBRCA14_(RAD21) 156 AZD6482 PI3Kbeta 21 26 1.63315443905142 NA 2.2758452472671 1.87356963457498 0.40227561269212 1.21566609023168 1.62754651057542 0.275736028432925 0.33090962717851 0.247166892053915 0.352331682381817 NA NA NA 0.337625517896581 98.9082052833041 a4122 gain_cnaBRCA61_(NOTCH2) 299 OSI-027 MTORC1/2 3 45 2.99573227355399 NA 2.30948337172397 1.19960197642421 1.10988139529976 1.16315958045669 2.0103237809539 0.560252414263357 0.954195291813687 0.552090865071059 0.352344988804807 NA NA NA 0.232331534410414 98.9082052833041 a4123 NF1_mut 1020 Lenalidomide TNFA 4 41 1.6094379124341 NA 4.57264765963155 4.2237098858844 0.348937773747148 0.659236791660667 0.712395673526973 0.492282380969734 0.529305673107455 0.489808945665834 0.352575757215875 NA NA NA 0.376574122149451 98.9082052833041 a4124 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1021 Axitinib PDGFR, KIT, VEGFR 15 30 0.693147180559945 NA 2.69374819237538 2.34665369474662 0.347094497628762 0.972099137396658 1.25158198268926 0.29718183027599 0.357056687199931 0.277324619904613 0.352584215059446 NA NA NA 0.313492202539313 98.9082052833041 a4125 gain_cnaBRCA10_(MDM2,NUP107) 1028 VX-702 p38 3 42 0.693147180559945 NA 3.78448189254002 3.40128497032376 0.383196922216261 0.318377076789797 0.695255904034694 0.561577467649281 1.20359457433319 0.551159537074768 0.352621050507621 NA NA NA 0.154636940371743 98.9082052833041 a4126 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 8 34 1.38629436111989 0.693147180559945 3.1217830575556 3.50675843280132 -0.384975375245725 0.793794983242278 1.08723093721791 0.369506802605842 0.484980862027222 0.354087951388535 0.352690424357491 NA NA NA 0.272433381905894 98.9082052833041 a4127 gain_cnaBRCA64_(SDHC) 255 CP724714 ERBB2 8 40 2.32630161961136 NA 3.29855857403021 3.90393110745746 -0.605372533427257 1.77342128843598 1.64522508220273 0.363506348152604 0.341358557819698 0.367957272215148 0.352854160472606 NA NA NA 0.394377621277455 98.9082052833041 a4128 gain_cnaBRCA48 202 GSK-1904529A IGF1R 5 43 0.0237165266173161 NA 1.85945226707796 2.2280723502311 -0.368620083153139 1.09547771327789 0.801559786315417 0.443450753071738 0.336492544471904 0.459878463773238 0.352878717433788 NA NA NA 0.501477293067389 98.9082052833041 a4129 BRCA2_mut 186 Bexarotene Retinioic acid X family agonist 6 41 2.07944154167984 NA 4.01157083644593 3.54482028551436 0.466750550931573 0.83925173625383 1.16987091643568 0.410189794633275 0.556150831471625 0.398976112983176 0.353031563559638 NA NA NA 0.263040162783226 98.9082052833041 a4130 loss_cnaBRCA42 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 3 45 2.07944154167984 NA 3.82203563374778 3.17378797195416 0.648247661793618 0.589145016860212 1.17821482507216 0.559390484836003 1.10031934963719 0.550194793002978 0.353079308740115 NA NA NA 0.183267949767063 98.9082052833041 a4131 loss_cnaBRCA22_(SYNCRIP,ZNF292) 87 GW843682X PLK1 3 9 -1.36257783450257 NA -2.84569756709291 -1.6043704653933 -1.24132710169961 1.69958215858271 1.96147102659093 0.649241486001434 0.730371930201222 0.632855181071454 0.353093041364881 NA NA NA 0.35220397134346 98.9082052833041 a4132 PTEN_mut 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 4 22 2.30258509299405 NA 2.15716310917747 2.78870251280893 -0.63153940363146 1.41421514785277 1.19779316320759 0.514729142190022 0.446565294248432 0.527252469817287 0.353095020296236 NA NA NA 0.450194909489132 98.9082052833041 a4133 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 263 FR-180204 ERK 6 43 2.99573227355399 NA 5.0954700006438 5.39450092035474 -0.299030919710937 0.778385774393871 0.726023033049846 0.408639657163289 0.384168017386741 0.411875252021662 0.353205159857453 NA NA NA 0.40696888161331 98.9082052833041 a4134 loss_cnaBRCA42 197 Bryostatin 1 PRKC 3 45 -4.8283137373023 NA -2.30121810487226 -2.84050964430512 0.539291539432856 0.19680122653328 0.98536300432884 0.559096227637426 2.74028545925582 0.547302402326525 0.353330229624422 NA NA NA 0.012601543038123 98.9082052833041 a4135 loss_cnaBRCA28_(GPS2) 302 PI-103 PI3Ka, PRKDC (DNAPK) 4 44 2.32630161961136 NA 0.297859793275812 1.20393982905282 -0.906080035777012 0.226326062663441 1.91297648596004 0.489654400734316 4.00342773215828 0.47364933255951 0.3533384102019 NA NA NA 0.00549726706306152 98.9082052833041 a4136 PIK3CA_mut 1026 17-AAG HSP90 15 28 0 NA -1.24483437136716 -0.709441799614433 -0.53539257175273 1.92142735913882 1.70611979125863 0.300349404938816 0.278643149951134 0.313807139742376 0.353392721384665 NA NA NA 0.373866792360112 98.9082052833041 a4137 NF1_mut 166 FTI-277 Farnesyl transferase (FNTA) 4 43 0.0237165266173161 NA 2.6091753127596 2.21045420481422 0.39872110794538 0.351563063302494 0.836755404849247 0.490152719629433 1.13413822316797 0.476508553915125 0.353423227552175 NA NA NA 0.109915431528431 98.9082052833041 a4138 TP53_mut 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 9 5 1.38629436111989 NA 2.07384277604031 1.64471726602253 0.429125510017781 0.792100438212752 0.806861491169271 0.538391422495966 0.541756435567734 0.531845322542175 0.353469344038615 NA NA NA 0.364468654120377 98.9082052833041 a4139 loss_cnaBRCA57 1243 piperlongumine Increases ROS levels 5 42 2.30258509299405 NA 2.04775646042917 1.6700674955653 0.377688964863873 0.667805635562956 0.867773213557213 0.44334833672806 0.565567202117848 0.435239252564197 0.353687681562278 NA NA NA 0.294232505127441 98.9453893406527 a4140 loss_cnaBRCA34 152 CP466722 ATM 5 44 2.77258872223978 NA 2.3097236452286 2.77791654652367 -0.468192901295072 0.872095758328759 1.07514484990409 0.44194978941034 0.536859509777107 0.43546960331609 0.353826840967005 NA NA NA 0.313849227051063 98.9492775774712 a4141 gain_cnaBRCA13_(FGFR1,WHSC1L1) 225 Genentech Cpd 10 AURKA, AURKB 11 38 2.32630161961136 NA 3.41845945259868 2.90215933997118 0.516300112627503 1.7054549758125 1.58421911072587 0.320528341446279 0.302734531224743 0.325901959603897 0.353969257365497 NA NA NA 0.382976282972975 98.9492775774712 a4142 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 231 FMK RSK 6 43 2.99573227355399 2.32630161961136 5.8012878308659 5.55964019036772 0.241647640498178 0.441419372595274 0.607792114367376 0.407969198963365 0.547433247157773 0.39758271748836 0.353988307157578 NA NA NA 0.267545181241593 98.9492775774712 a4143 gain_cnaBRCA62 140 Vinorelbine Microtubules 9 38 -2.74887219562247 NA -3.13869913942654 -3.70902926801092 0.57033012858438 2.03707973711893 1.54475654682492 0.347106655953837 0.279974376158199 0.369203891549533 0.354103397310582 NA NA NA 0.448488387989192 98.9492775774712 a4144 loss_cnaBRCA36_(FAT1,IRF2) 256 JW-7-24-1 LCK 9 39 2.32630161961136 NA 2.16428181930174 1.76217389233305 0.402107926968696 1.32598907006408 1.12397750437302 0.346156493613412 0.303251313337948 0.357754426048766 0.354128859384265 NA NA NA 0.417716591530805 98.9492775774712 a4145 loss_cnaBRCA23 294 MPS-1-IN-1 MPS1 3 46 2.99573227355399 NA 5.36885540477262 4.71658263544429 0.652272769328331 1.27479204855751 1.16537191531447 0.557385411592195 0.511669938690323 0.559712106286961 0.35436392413401 NA NA NA 0.471077978676299 98.9715901372111 a4146 BRCA1_mut 153 Midostaurin KIT 4 43 -0.669430653942629 NA 1.26227412574349 0.551710570485489 0.710563555257997 1.73672716127055 1.4303351824813 0.489108432840809 0.409139426792961 0.496781148894998 0.354439923873286 NA NA NA 0.479238892393519 98.9715901372111 a4147 gain_cnaBRCA64_(SDHC) 1039 SL 0101-1 RSK, AURKB, PIM3 7 36 2.30258509299405 NA 4.33715824110446 4.70943088211025 -0.372272641005788 1.46160271406303 0.847605594657511 0.386877252668667 0.254701662376452 0.439205030443683 0.354465138871245 NA NA NA 0.535264302834459 98.9715901372111 a4148 gain_cnaBRCA14_(RAD21) 5 Sunitinib PDGFRA, PDGFRB, KDR, KIT, FLT3 6 6 2.07944154167984 NA 2.86869893436944 3.64210854812358 -0.773409613754137 1.30710866776687 1.44934916339397 0.560416290021253 0.591694962191223 0.533625459818826 0.354604902688766 NA NA NA 0.354841069998518 98.9743071154513 a4149 loss_cnaBRCA22_(SYNCRIP,ZNF292) 229 LY317615 PRKCB (PKCbeta) 19 30 2.99573227355399 2.32630161961136 3.62882805929672 3.18742791338796 0.44140014590876 1.59703715045241 1.61956044146301 0.273996212290509 0.276386899192494 0.272543175671806 0.354817524245001 NA NA NA 0.354285270539587 98.9743071154513 a4150 gain_cnaBRCA8_(CHD4,WNK1) 1091 BMS-536924 IGF1R 3 44 1.38629436111989 NA 3.59381142124787 2.98440386450902 0.609407556738853 0.876091106280254 1.1014297046271 0.557860092583996 0.695598382828359 0.553287744264329 0.354831832146743 NA NA NA 0.351672259458194 98.9743071154513 a4151 gain_cnaBRCA16 153 Midostaurin KIT 16 31 -0.669430653942629 NA 0.887930333231296 0.469863409746749 0.418066923484547 1.48075336849342 1.4386163187229 0.287766764801204 0.282333933779875 0.290603490342495 0.354865617621708 NA NA NA 0.361886541455242 98.9743071154513 a4152 gain_cnaBRCA63 1067 CCT007093 PPM1D 6 40 1.88706964903238 NA 4.43559477984737 4.03314244051509 0.402452339332281 0.760507494226599 1.00880602645129 0.409099574872263 0.529189182733244 0.398939269571971 0.355172366803804 NA NA NA 0.282536913299605 98.9743071154513 a4153 gain_cnaBRCA19 330 XMD13-2 RIPK 4 44 2.32630161961136 NA 3.1781800049909 3.77037044790187 -0.592190442910967 1.785672746245 1.16405204985105 0.487667951332128 0.331634362542774 0.50873192739684 0.355276436431837 NA NA NA 0.558435460462506 98.9743071154513 a4154 gain_cnaBRCA14_(RAD21) 1241 CHIR-99021 GSK3B 20 26 2.30258509299405 NA 4.38473714728178 4.11360243495246 0.271134712329322 0.808117465093493 1.08603565184677 0.277863239522711 0.335513986568714 0.249655443509857 0.355284134219586 NA NA NA 0.337001741730335 98.9743071154513 a4155 loss_cnaBRCA17 1003 Camptothecin TOP1 8 37 -2.30258509299405 NA -3.00420934749862 -2.42659432976578 -0.577615017732837 1.6849388215819 1.56523615869801 0.364348027486143 0.342810676764242 0.369027392143372 0.355289992433645 NA NA NA 0.394748523138974 98.9743071154513 a4156 gain_cnaBRCA27_(CLTC,PPM1D) 328 SNX-2112 HSP90 9 39 0.940007258491471 NA -0.15389028408492 0.54903924310808 -0.702929527193001 2.4095574614743 1.94844046737445 0.345224831102456 0.291725571368159 0.360765206308925 0.355413580785975 NA NA NA 0.432660420120953 98.9743071154513 a4157 CDH1_mut 1268 XAV 939 TNKS1 (tankyrase-1) 5 42 1.6094379124341 NA 4.03137365737172 3.61740328438619 0.413970372985527 0.984097789368973 0.932847989736237 0.441560399550991 0.4206597936278 0.443770450856175 0.355613627711181 NA NA NA 0.413095325048758 98.9743071154513 a4158 gain_cnaBRCA27_(CLTC,PPM1D) 283 GSK2126458 PI3K, MTOR 9 39 -2.05572501506252 0.0237165266173161 -3.5125925175386 -2.94984222396134 -0.562750293577255 2.23230058720731 1.47358386035875 0.345015577814075 0.252094317764471 0.381892275503243 0.355702549014715 NA NA NA 0.488031423678102 98.9743071154513 a4159 BRCA2_mut 238 CAL-101 PI3Kdelta 6 43 2.99573227355399 2.32630161961136 4.38230534311042 4.76593987659318 -0.383634533482757 0.812319672344492 0.958243398323187 0.406481803631992 0.472270396179774 0.400351866920317 0.355729740243173 NA NA NA 0.324468695193933 98.9743071154513 a4160 loss_cnaBRCA7_(FAS,PTEN) 224 AS605240 PI3Kgamma 4 45 2.99573227355399 2.32630161961136 3.97533410385681 3.20758320669871 0.767750897158105 1.49134458470676 1.58361753438385 0.486568381501113 0.514804495910024 0.484808282611508 0.355807475114789 NA NA NA 0.38712238634401 98.9743071154513 a4161 loss_cnaBRCA38 230 GSK429286A ROCK2 4 45 2.99573227355399 2.32630161961136 5.00544672371659 5.4410641959976 -0.43561747228101 0.459416759577003 0.917660980276355 0.486481274528108 0.948196736841066 0.474704146350239 0.355892814428436 NA NA NA 0.159245768393192 98.9743071154513 a4162 loss_cnaBRCA18 1218 JQ1 BRD2, BRD3, BRD4 15 31 0 NA 2.59655648186413 2.39092964143144 0.205626840432688 0.680676253192449 0.709902112787433 0.2934444256245 0.302091984946257 0.289655202779005 0.355920812121423 NA NA NA 0.351481394735435 98.9743071154513 a4163 PIK3CA_mut 1038 NU-7441 PRKDC (DNAPK) 15 28 0.693147180559945 NA 3.07629040277648 2.79460141543885 0.281688987337623 0.937744649716696 0.945512874477539 0.298757763503241 0.300389863512124 0.297921895027897 0.355922721713562 NA NA NA 0.356968912197401 98.9743071154513 a4164 BRCA1_mut 1495 AZD-2281 PARP1, PARP2 4 41 2.30258509299405 NA 3.49651573685224 4.04768403452635 -0.551168297674111 1.10175407559176 1.129615116149 0.488757113280469 0.500264360155032 0.487925745499149 0.355999814139974 NA NA NA 0.399492778671436 98.9743071154513 a4165 gain_cnaBRCA30_(CRNKL1,FOXA2) 306 TG101348 JAK2 5 43 2.32630161961136 NA 3.73037528786931 3.16611144837664 0.564263839492676 1.83770526025296 1.21455352168792 0.440544405268832 0.307048062437937 0.464585404773677 0.356013463283405 NA NA NA 0.536406203391735 98.9743071154513 a4166 loss_cnaBRCA18 1091 BMS-536924 IGF1R 15 32 1.38629436111989 NA 2.80635666674421 3.12499544690554 -0.318638780161324 1.04198356230253 1.11451279173886 0.291669749910591 0.305800198476462 0.285899616875804 0.356258430765204 NA NA NA 0.347137870926062 98.9839635470697 a4167 gain_cnaBRCA8_(CHD4,WNK1) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 3 42 2.30258509299405 NA 0.793357155696298 1.40617879101898 -0.612821635322681 1.22467215350889 1.0937385014264 0.557022454138003 0.500396480451397 0.560299957003863 0.35650094704751 NA NA NA 0.479813621576527 98.9839635470697 a4168 POLR2B_mut 1243 piperlongumine Increases ROS levels 3 44 2.30258509299405 NA 1.26686614356053 1.74047769739106 -0.473611553830527 1.11408398401822 0.837814600553471 0.555883650973997 0.425112972293461 0.565293984513582 0.356522943939881 NA NA NA 0.54023695350939 98.9839635470697 a4169 PTEN_mut 266 Zibotentan, ZD4054 Endothelin A Receptor 9 40 2.99573227355399 NA 5.60418992373766 5.77305551317519 -0.168865589437531 0.721307558159154 0.429554517338114 0.343503121374453 0.234110384020503 0.39311794573589 0.356573699000469 NA NA NA 0.515542414383152 98.9839635470697 a4170 loss_cnaBRCA18 34 Imatinib ABL, KIT, PDGFR 6 8 0.693147180559945 NA 2.91641824999194 2.67313838459121 0.243279865400732 0.304011389130595 0.559083530498307 0.517681636441304 0.800232735018442 0.435140461361648 0.356695783918789 NA NA NA 0.319282903329165 98.9839635470697 a4171 loss_cnaBRCA24 291 KIN001-266 MAP3K8 (COT) 3 46 2.99573227355399 NA 3.16554949380231 3.81861820777652 -0.65306871397421 0.326395796143857 1.2017850812835 0.554452091438733 2.00084903570993 0.543415560856136 0.356879144826784 NA NA NA 0.0401881942978162 98.9839635470697 a4172 BRCA2_mut 134 Etoposide TOP2 6 41 2.77258872223978 NA 1.71225762681502 2.58903009741986 -0.876772470604836 2.36381507452538 2.12764414627434 0.406824054454785 0.370914154856585 0.412086049323675 0.356958040298132 NA NA NA 0.422057109091896 98.9839635470697 a4173 loss_cnaBRCA20 133 Doxorubicin DNA intercalating 3 45 0.0237165266173161 NA -0.0777868252665837 -1.09416886075177 1.01638203548518 1.008963892623 1.86067249701888 0.554825661129729 1.00735223818852 0.546244455761883 0.35698495834865 NA NA NA 0.213182313378219 98.9839635470697 a4174 PIK3CA_mut 59 WZ-1-84 BMX 4 8 2.32630161961136 NA 3.09151796389654 3.79708656419434 -0.705568600297802 1.81324220830881 0.791086945059994 0.591179164327496 0.389119885399027 0.891897666500226 0.357114522940997 NA NA NA 0.502855653651689 98.9839635470697 a4175 ASH1L_mut 1502 Bicalutamide ANDR (androgen receptor) 3 42 2.30258509299405 NA 4.25599341808294 4.57989668401081 -0.323903265927861 0.533187381823721 0.584696752566014 0.556150681470927 0.607484867364974 0.553967957759934 0.357246674542121 NA NA NA 0.404818703610918 98.9839635470697 a4176 loss_cnaBRCA34 305 TPCA-1 IKK 5 44 2.99573227355399 NA 3.63529701154285 4.24003424680807 -0.604737235265216 0.782755823922308 1.4214136032576 0.438651915715859 0.772574558736517 0.425447761214103 0.357397214699663 NA NA NA 0.181532921504835 98.9839635470697 a4177 gain_cnaBRCA58_(CCND1) 165 DMOG Prolyl-4-Hydroxylase 9 37 8.29404964010203 NA 7.99600675075003 7.46635258988542 0.529654160864608 1.30494107258569 1.57833486717272 0.345668707106093 0.40588358508413 0.335577811705687 0.357423326542457 NA NA NA 0.313037886925107 98.9839635470697 a4178 gain_cnaBRCA9_(KRAS) 1230 IOX2 EGLN1 4 43 -2.30258509299405 NA 0.539672041217027 0.222466495666701 0.317205545550326 0.134990238358347 0.674591172956996 0.486028271540455 2.34984062112898 0.470218938916575 0.3574498144199 NA NA NA 0.0165273707168965 98.9839635470697 a4179 loss_cnaBRCA33 225 Genentech Cpd 10 AURKA, AURKB 6 43 2.32630161961136 NA 2.44562231635739 3.09793895347316 -0.652316637115768 1.74018361626561 1.59492365099277 0.404914231348502 0.374855061855841 0.408995525716688 0.357571069838905 NA NA NA 0.417211920289653 98.9839635470697 a4180 PIK3CA_mut 1203 QL-XII-61 BTK 10 13 2.30258509299405 NA 3.88895906730811 4.48386640019399 -0.594907332885882 1.97237524269861 1.01938849686635 0.395633901812392 0.301619752675422 0.583592354352294 0.357608633285814 NA NA NA 0.401146998528264 98.9839635470697 a4181 gain_cnaBRCA13_(FGFR1,WHSC1L1) 345 KIN001-270 CDK9 11 38 2.99573227355399 NA 5.27755845898582 5.05838472031084 0.219173738674979 0.716544821743573 0.681534241546953 0.318043060304215 0.305875825243789 0.321588740981667 0.357679485146447 NA NA NA 0.380180849125604 98.9839635470697 a4182 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1239 YK 4-279 RNA helicase A 6 36 2.30258509299405 NA 1.5591872903026 2.08928047845716 -0.53009318815456 0.860768436171142 1.34229997655977 0.410301213889485 0.615837158844384 0.394914100731162 0.357706773429091 NA NA NA 0.233006855416124 98.9839635470697 a4183 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 279 BIX02189 MAP2K5 (MEK5) 6 43 2.99573227355399 NA 4.70822457587632 5.07188601691765 -0.363661441041325 0.485731755865049 0.935564246997163 0.404752171769288 0.748687802784632 0.388708142929309 0.357761783758237 NA NA NA 0.164285501342966 98.9839635470697 a4184 loss_cnaBRCA29_(MAP2K4) 193 GW-2580 CSF1R (cFMS) 7 41 2.99573227355399 NA 5.70495995227035 5.42214502379137 0.282814928478984 0.450478254707444 0.779066433680151 0.379883678941729 0.627810389344219 0.363017730263419 0.357787677166228 NA NA NA 0.19930084675017 98.9839635470697 a4185 gain_cnaBRCA19 1059 AZD8055 MTORC1/2 3 40 0.693147180559945 NA 0.651025525604077 0.0913861242526677 0.559639401351409 1.2175649180194 0.993666463072792 0.556442410256904 0.45963824439174 0.563206490456358 0.358040746309 NA NA NA 0.511869866607917 98.9839635470697 a4186 gain_cnaBRCA14_(RAD21) 194 AUY922 HSP90 21 26 -1.36257783450257 NA -2.13387186463977 -2.60364628302966 0.469774418389893 1.75113437924319 1.70293172285713 0.272408564592176 0.268268628586301 0.275862157058016 0.358117228539769 NA NA NA 0.359860387150838 98.9839635470697 a4187 loss_cnaBRCA60 1373 Dabrafenib BRAF 3 43 2.30258509299405 NA 5.06055556466773 4.15556821759551 0.904987347072227 0.196701214475028 1.67001142208743 0.554474212683855 4.60082236648885 0.541904884663027 0.358197253558807 NA NA NA 0.00269048970479694 98.9839635470697 a4188 gain_cnaBRCA48 201 Epothilone B Microtubules 5 43 -3.44201937618241 NA -4.94342310085729 -4.15347127639118 -0.789951824466108 1.93336333512462 1.78837472894888 0.438509918939669 0.408589430716182 0.441714933497412 0.358218590087015 NA NA NA 0.424755971182419 98.9839635470697 a4189 BRCA1_mut 281 CH5424802 ALK 4 44 1.63315443905142 NA 4.04744774040027 3.53231161565159 0.515136124748679 0.534624089679873 1.09051213323095 0.484535046789283 0.963548285033577 0.472380002983042 0.358347022899949 NA NA NA 0.154929932711405 98.9839635470697 a4190 TP53_mut 193 GW-2580 CSF1R (cFMS) 37 11 2.99573227355399 NA 5.51774758655119 5.28054590354041 0.237201683010772 0.795915820654824 0.518765324549305 0.318607631130637 0.298023580955608 0.457242748861153 0.358377891880375 NA NA NA 0.255558744584866 98.9839635470697 a4191 gain_cnaBRCA31 89 Parthenolide NFKB1 4 10 1.6094379124341 NA 3.81318475766327 3.02453799256524 0.788646765098037 1.6289138698009 1.31005929660198 0.564684710435807 0.484154981868029 0.601993182402981 0.358667941782026 NA NA NA 0.430356156949684 98.9839635470697 a4192 gain_cnaBRCA14_(RAD21) 1022 AZD7762 CHEK1, CHEK2 20 25 0.693147180559945 NA 1.15522042772635 0.704374891932072 0.450845535794276 1.65250062788051 1.59335781521778 0.278341465346227 0.272826241750074 0.28295310161243 0.358687676670837 NA NA NA 0.361018308788571 98.9839635470697 a4193 gain_cnaBRCA31 200 LAQ824 HDAC 16 32 0.0237165266173161 NA -2.95093859806473 -2.55123181579512 -0.399706782269614 1.27101475861511 1.47024510022962 0.283806305520792 0.314478474431824 0.271864046482581 0.358812487393756 NA NA NA 0.337021184266202 98.9839635470697 a4194 loss_cnaBRCA33 308 XL-880 MET 6 43 1.63315443905142 NA 1.28018201062416 1.92692183633352 -0.646739825709362 1.78873459432951 1.57794329897913 0.403786630126249 0.361562764962225 0.409862525559554 0.358899415641553 NA NA NA 0.431814526174351 98.9839635470697 a4195 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 158 PF-562271 FAK 4 41 0.940007258491471 NA 1.76384653462834 2.38880178320499 -0.624955248576642 1.4543211151915 1.27307533000189 0.485760857840377 0.429723010997025 0.490902018009973 0.35892705393075 NA NA NA 0.46037504063602 98.9839635470697 a4196 loss_cnaBRCA24 328 SNX-2112 HSP90 3 45 0.940007258491471 NA -0.637507768916585 0.487556471804458 -1.12506424072104 1.4491969558457 2.05915122230362 0.552467827454681 0.776336326254906 0.546372810571148 0.359013281700555 NA NA NA 0.309131157217427 98.9839635470697 a4197 gain_cnaBRCA14_(RAD21) 281 CH5424802 ALK 21 27 1.63315443905142 NA 3.41402737459019 3.70062693273618 -0.286599558145988 1.22842785799333 0.916007696993057 0.269567345485174 0.233305974201983 0.31287898462731 0.359029798099562 NA NA NA 0.377654418094095 98.9839635470697 a4198 loss_cnaBRCA17 1230 IOX2 EGLN1 9 38 -2.30258509299405 NA 0.430703126129428 0.206537351141353 0.224165774988075 0.518262966879218 0.678263772152997 0.343447944050545 0.432532882559439 0.330499407740017 0.359151092904665 NA NA NA 0.290722674689842 98.9839635470697 a4199 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1527 GDC0941 (rescreen) PI3K 6 39 1.38629436111989 NA 1.38717092014701 0.918115060012324 0.469055860134683 1.05001350551069 1.16702916660799 0.406449447098525 0.446714120983187 0.401922996918758 0.359179018702389 NA NA NA 0.349024581412145 98.9839635470697 a4200 loss_cnaBRCA38 256 JW-7-24-1 LCK 4 44 2.32630161961136 NA 1.32261236779617 1.88438337962545 -0.56177101182928 0.715127733646216 1.18678118690456 0.483505022719129 0.785553384938635 0.473356856367541 0.359360313621377 NA NA NA 0.222913763169094 98.9839635470697 a4201 loss_cnaBRCA23 276 CAY10603 HDAC6 3 46 2.99573227355399 NA 0.66294240001978 1.20897000704766 -0.546027607027884 0.337501534413859 1.00943388008272 0.551446267172137 1.61785222095708 0.540924589318459 0.359468547757359 NA NA NA 0.0771170166770777 98.9839635470697 a4202 loss_cnaBRCA33 3 Rapamycin MTOR 5 9 -2.30258509299405 NA -1.84318224745069 -3.24170873844074 1.39852649099005 0.708007588867723 3.18375145007662 0.531463114757608 1.97529872981536 0.439269997334871 0.359475501400164 NA NA NA 0.237276062211894 98.9839635470697 a4203 TP53_mut 1039 SL 0101-1 RSK, AURKB, PIM3 34 9 2.30258509299405 NA 4.71879999160556 4.38449108101235 0.334308910593213 0.936870942107435 1.06153092234862 0.347347086906855 0.35683560623751 0.314930920574183 0.359559162323726 NA NA NA 0.407192671820469 98.9839635470697 a4204 gain_cnaBRCA48 170 Shikonin unknown 5 42 2.77258872223978 NA 0.467121583626617 -0.0515721805697775 0.518693764196395 0.706186917025174 1.22132498821947 0.437848973247162 0.734499254646917 0.424697577794246 0.359633319906392 NA NA NA 0.199774004559302 98.9839635470697 a4205 loss_cnaBRCA18 333 T0901317 LXR 15 33 2.32630161961136 NA 4.58425010522244 4.8041571609421 -0.219907055719654 0.798475401874268 0.747253678134854 0.288135571134178 0.275408679094514 0.294287016784638 0.359642962249445 NA NA NA 0.375416660562372 98.9839635470697 a4206 gain_cnaBRCA27_(CLTC,PPM1D) 273 CUDC-101 HDAC, EGFR 9 40 1.63315443905142 NA -0.462748782293943 0.071474049680122 -0.534222831974065 1.53928345414325 1.57156679936108 0.341112593814081 0.347059425953102 0.339930082635528 0.359900220929405 NA NA NA 0.367113555167769 98.9839635470697 a4207 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 271 VNLG/124 HDAC, RAR 6 43 1.63315443905142 NA 3.86438801456941 4.19149388577877 -0.32710587120936 0.845074691373797 0.807845976766845 0.402895500292669 0.387073325646044 0.404911184330583 0.359951453743801 NA NA NA 0.404500212035732 98.9839635470697 a4208 TP53_mut 155 AP-24534 ABL 37 10 -0.669430653942629 NA 1.52479963157391 1.15143223947226 0.373367392101653 1.13339961679546 1.13054218626798 0.329588568596326 0.329422550148111 0.330255161317043 0.360028900878248 NA NA NA 0.369760349096315 98.9839635470697 a4209 loss_cnaBRCA60 156 AZD6482 PI3Kbeta 3 44 1.63315443905142 NA 1.29952810642799 2.10470400846079 -0.805175902032804 1.63602299401719 1.45062601684378 0.551729892874544 0.492154392069836 0.555054088844123 0.360094123546688 NA NA NA 0.486042510657236 98.9839635470697 a4210 gain_cnaBRCA12_(TERT) 200 LAQ824 HDAC 9 39 0.0237165266173161 NA -2.29330580636868 -2.7747354722349 0.481429665866221 1.11572307240629 1.46263126725777 0.341815069248765 0.431495662116153 0.329153134247454 0.360141352766867 NA NA NA 0.290511264328354 98.9839635470697 a4211 loss_cnaBRCA20 238 CAL-101 PI3Kdelta 3 46 2.99573227355399 2.32630161961136 5.20683604473399 4.68714649169494 0.519689553039052 0.767069977551256 0.951052036674186 0.550545544015494 0.677499534916065 0.546436507150963 0.360246853143167 NA NA NA 0.361923335623932 98.9839635470697 a4212 PTEN_mut 1262 UNC1215 LMBL3 8 38 0 NA 2.5813573246512 2.79460725409721 -0.213249929446011 0.694459988433907 0.57175029079912 0.359628207762447 0.307073025080848 0.372977386942745 0.360263581861298 NA NA NA 0.437234732730218 98.9839635470697 a4213 gain_cnaBRCA19 1091 BMS-536924 IGF1R 4 43 1.38629436111989 NA 2.54032528992567 3.06823030563809 -0.527905015712415 1.15043595329998 1.08839172132661 0.483147392627283 0.458873885328548 0.48503218590175 0.360279978495658 NA NA NA 0.43399945367065 98.9839635470697 a4214 gain_cnaBRCA9_(KRAS) 1046 681640 WEE1, CHEK1 3 33 0.693147180559945 NA 3.17915965115387 2.58421626836887 0.594943382784999 0.693093191099894 1.08295983532229 0.559163441448471 0.858388728131729 0.549367911329734 0.360323617033671 NA NA NA 0.271909666200744 98.9839635470697 a4215 loss_cnaBRCA7_(FAS,PTEN) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 4 43 -2.30258509299405 NA -0.598145871933851 -0.0980439490898484 -0.500101922844003 0.97762923111192 1.03944464132837 0.482985668238744 0.511545591036804 0.48112415318712 0.360439285790382 NA NA NA 0.390274275810034 98.9839635470697 a4216 PIK3CA_mut 41 S-Trityl-L-cysteine KIF11 4 8 1.63315443905142 NA 1.85830979562602 0.907063873597719 0.951245922028304 2.06604932977845 1.3868573372174 0.586906096164628 0.460417816901937 0.685900342090624 0.360452249929221 NA NA NA 0.448175932408219 98.9839635470697 a4217 loss_cnaBRCA7_(FAS,PTEN) 228 KIN001-102 AKT1 4 45 2.32630161961136 NA 2.56499933413529 1.8884773081441 0.676522025991191 0.224737715136093 1.45042232905214 0.4816758684436 3.01027366760187 0.4664310611057 0.360621337079592 NA NA NA 0.00884363487051027 98.9839635470697 a4218 gain_cnaBRCA31 166 FTI-277 Farnesyl transferase (FNTA) 16 31 0.0237165266173161 NA 2.39696566719208 2.16563810912827 0.231327558063808 1.09972676577491 0.62325959309581 0.284292329497251 0.210350029901114 0.371157637405587 0.36065017779008 NA NA NA 0.444888481084086 98.9839635470697 a4219 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 281 CH5424802 ALK 14 34 1.63315443905142 NA 3.79605897269569 3.48431401272151 0.311744959974182 1.18973601969525 1.00907862892568 0.293200008767114 0.262028680996005 0.308940206479334 0.360664428884262 NA NA NA 0.398834099875524 98.9839635470697 a4220 ASH1L_mut 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 3 46 1.63315443905142 NA 3.06122153232944 3.61027224814122 -0.549050715811774 0.666640391025489 1.01060739739654 0.549937486259139 0.823608534981165 0.543287845731393 0.360772886341442 NA NA NA 0.286589798514402 98.9870500778294 a4221 gain_cnaBRCA15 119 Lapatinib ERBB2, EGFR 6 7 0.693147180559945 NA 0.804445164847296 1.98890595592886 -1.18446079108156 2.84168758995259 1.55297968781078 0.53044810207097 0.41681597768505 0.7627020497295 0.360846652023938 NA NA NA 0.390703275307261 98.9870500778294 a4222 CDH1_mut 1025 SB 216763 GSK3A, GSK3B 3 36 2.30258509299405 NA 4.48656188707601 4.92271128709175 -0.43614940001574 0.452529826865209 0.799965426134176 0.555515342733489 0.963802547639919 0.545210312554915 0.36125076650658 NA NA NA 0.229143386548955 99.0372124530328 a4223 loss_cnaBRCA22_(SYNCRIP,ZNF292) 262 VX-11e ERK 19 30 1.63315443905142 NA 3.99657738963819 3.6376271627481 0.358950226890087 1.07190725573397 1.46544473991967 0.270177171095271 0.3348706009498 0.244942860765779 0.361503591946445 NA NA NA 0.328445811526982 99.0372124530328 a4224 loss_cnaBRCA42 304 SB52334 ALK5 3 46 2.99573227355399 NA 3.64653438624668 4.34463244531467 -0.698098059067986 0.312031350907627 1.29767681970862 0.549079551351489 2.23726897004862 0.537959874496901 0.361515934857584 NA NA NA 0.0272952230936298 99.0372124530328 a4225 gain_cnaBRCA8_(CHD4,WNK1) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 3 42 0.693147180559945 NA 1.3625697395299 0.572926006843263 0.78964373268664 1.38576008457733 1.43555346077305 0.550936327721542 0.569827159459197 0.550062226356525 0.361728321876166 NA NA NA 0.429852590744873 99.0372124530328 a4226 loss_cnaBRCA36_(FAT1,IRF2) 1529 MLN4924 NEDD8-activating enzyme 8 29 0 NA -0.121305487326899 0.504531343984662 -0.625836831311562 1.72021691458197 1.68956454957083 0.369064285506009 0.363812741292366 0.370413093403582 0.361733226253465 NA NA NA 0.380016090744919 99.0372124530328 a4227 ARID1A_mut 1192 GSK269962A ROCK1, ROCK2 5 41 1.6094379124341 NA 2.09959317173196 2.73725467059679 -0.637661498864828 1.64798870633244 1.44123708220931 0.436383226276487 0.386933172790929 0.442440391477673 0.361956268798684 NA NA NA 0.447316582395773 99.0372124530328 a4228 loss_cnaBRCA22_(SYNCRIP,ZNF292) 52 GNF-2 ABL [T315I] 3 9 0.246860077931526 NA 2.21912527728345 2.57607530301983 -0.356950025736389 0.368876597003643 0.598905497760203 0.636838122346157 0.967667855960144 0.596003922273742 0.36196948617875 NA NA NA 0.267860728821381 99.0372124530328 a4229 loss_cnaBRCA60 341 EX-527 SIRT1 3 46 2.99573227355399 NA 5.30530949791486 5.66369522189289 -0.358385723978028 0.28451108037591 0.665223786432768 0.548362030178643 1.25965471539636 0.538744601872785 0.362138132389519 NA NA NA 0.140938813724338 99.0372124530328 a4230 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 170 Shikonin unknown 14 33 2.77258872223978 NA 0.247779591746296 -0.0999799378862339 0.34775952963253 1.36810550391248 1.10160231329398 0.293525969863684 0.254190578605243 0.315685184604115 0.362335250159689 NA NA NA 0.409346266157988 99.0372124530328 a4231 gain_cnaBRCA64_(SDHC) 292 Masitinib KIT 8 40 2.99573227355399 NA 3.68731651173327 4.07492955532182 -0.387613043588553 1.19145359499046 1.06816007879034 0.356319643727989 0.32532785600572 0.362879170720847 0.362365433614223 NA NA NA 0.414324468099155 99.0372124530328 a4232 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 229 LY317615 PRKCB (PKCbeta) 6 43 2.99573227355399 2.32630161961136 2.79180130628881 3.43766889978008 -0.645867593491272 2.30517463412743 1.50773161058805 0.40080296497395 0.280181633065623 0.42837040024608 0.362429679403663 NA NA NA 0.531401297182064 99.0372124530328 a4233 MACF1_mut 1261 rTRAIL TR10A (DR4), TR10B (DR5) 3 44 -2.30258509299405 NA 0.39160873839978 -0.176893170768142 0.568501909167922 0.671711437878006 1.04937581369325 0.549001550390074 0.846348412591973 0.541752441546269 0.362452395409666 NA NA NA 0.276393089685729 99.0372124530328 a4234 gain_cnaBRCA27_(CLTC,PPM1D) 1218 JQ1 BRD2, BRD3, BRD4 10 36 0 NA 2.6384231568313 2.40785929288954 0.230563863941759 0.764022246536652 0.683752881550816 0.32894469124592 0.301776374951012 0.337203498753553 0.362471760954317 NA NA NA 0.403395921233018 99.0372124530328 a4235 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 203 BMS-345541 IKBKB 7 42 2.77258872223978 NA 3.20841724486384 3.58631796219967 -0.377900717335837 1.046833304084 1.00065964122003 0.37539604324992 0.360994167707062 0.377651602771838 0.362514488009614 NA NA NA 0.399755021592533 99.0372124530328 a4236 PTEN_mut 1059 AZD8055 MTORC1/2 6 37 0.693147180559945 NA -0.220301260330494 0.187306192132484 -0.407607452462978 1.32126103432619 0.953940567598951 0.405199482851522 0.30849880672584 0.427288099812043 0.362600584513824 NA NA NA 0.495946956567128 99.0372124530328 a4237 loss_cnaBRCA7_(FAS,PTEN) 1028 VX-702 p38 4 41 0.693147180559945 NA 3.12704742603555 3.4560786518799 -0.329031225844344 0.768371857770786 0.675772745052447 0.48199754746682 0.428218736171488 0.486896265428414 0.362625806601804 NA NA NA 0.461887235177526 99.0372124530328 a4238 TP53_mut 153 Midostaurin KIT 37 10 -0.669430653942629 NA 0.713532165862651 0.237196089693186 0.476336076169465 1.44392371699983 1.48993972781666 0.327774443655013 0.329890056213767 0.319701574014328 0.36265450444266 NA NA NA 0.381948722556076 99.0372124530328 a4239 gain_cnaBRCA48 330 XMD13-2 RIPK 5 43 2.32630161961136 NA 4.19370073568706 3.66605851277234 0.527642222914716 0.881758847737423 1.24173897466653 0.434388263068176 0.598397423817903 0.424922011533395 0.362713084272409 NA NA NA 0.272949350887063 99.0372124530328 a4240 gain_cnaBRCA30_(CRNKL1,FOXA2) 272 AR-42 HDAC 5 44 1.63315443905142 NA 0.737029555380057 0.0743480595048028 0.662681495875254 3.28010069901255 1.24509161403536 0.433766638081657 0.202030838893071 0.532235129050057 0.362729032444217 NA NA NA 0.676576102150071 99.0372124530328 a4241 loss_cnaBRCA29_(MAP2K4) 346 THZ-2-102-1 CDK7 7 41 0.916290731874155 2.99573227355399 -2.15082674423161 -1.19589705968198 -0.954929684549636 2.41098553673968 2.55954268751866 0.375859151759734 0.396074414382827 0.373086055257547 0.362856796136856 NA NA NA 0.363780761197903 99.0372124530328 a4242 PIK3CA_mut 166 FTI-277 Farnesyl transferase (FNTA) 16 31 0.0237165266173161 NA 2.09250746976698 2.32277782392833 -0.230270354161347 1.10223509272623 0.621178369385103 0.282968613617835 0.20891219639161 0.370699247607879 0.362870023182555 NA NA NA 0.447630968050233 99.0372124530328 a4243 gain_cnaBRCA14_(RAD21) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 19 24 1.6094379124341 NA 3.09257567541692 2.69013738478574 0.402438290631181 1.32354474834959 1.49919893860757 0.282462052513547 0.304060962905112 0.268435549324067 0.36304122556488 NA NA NA 0.356092858091616 99.0372124530328 a4244 gain_cnaBRCA62 206 Ruxolitinib JAK1, JAK2, TYK2 10 39 1.65632149833295 0.0237165266173161 4.5392372887284 4.32693305838283 0.212304230345568 0.76371447384215 0.623195107055761 0.325395382667658 0.277989009789866 0.340670566796623 0.363302699020868 NA NA NA 0.432036336327029 99.0372124530328 a4245 loss_cnaBRCA38 1018 ABT-888 PARP1, PARP2 3 42 1.6094379124341 NA 4.0631649043452 4.42735556971313 -0.364190665367929 0.354058698623481 0.674760450817475 0.549065896508911 1.02861662990865 0.539733271158246 0.363344777838265 NA NA NA 0.205965029023622 99.0372124530328 a4246 MACF1_mut 1239 YK 4-279 RNA helicase A 3 39 2.30258509299405 NA 1.35247045519875 2.06440537437634 -0.711934919177589 0.18128548769234 1.32520106946382 0.550912901771745 3.92714788282344 0.53722784834881 0.363346679003029 NA NA NA 0.00553852231513369 99.0372124530328 a4247 gain_cnaBRCA47_(EGFR) 1046 681640 WEE1, CHEK1 5 31 0.693147180559945 NA 3.04068849876443 2.56816688115523 0.472521617609206 0.79890358123216 1.09467630078449 0.444034611147068 0.591462635428958 0.431654195190466 0.363352077543466 NA NA NA 0.286164180422179 99.0372124530328 a4248 loss_cnaBRCA28_(GPS2) 153 Midostaurin KIT 4 43 -0.669430653942629 NA 1.25037163315131 0.552817779098714 0.697553854052596 1.47687626525441 1.45158600007554 0.479983976497746 0.472317058959869 0.480546005552752 0.363404407177541 NA NA NA 0.422543369866166 99.0372124530328 a4249 gain_cnaBRCA14_(RAD21) 1020 Lenalidomide TNFA 20 25 1.6094379124341 NA 4.36329342373433 4.167873099404 0.195420324330326 0.764611988515918 0.661925859175238 0.275575736178395 0.255581036218944 0.295229928883304 0.363436429351971 NA NA NA 0.371849383693197 99.0372124530328 a4250 CDH1_mut 197 Bryostatin 1 PRKC 4 44 -4.8283137373023 NA -2.3830227584207 -2.8453294835151 0.462306725094394 0.414715231485195 0.992028380386144 0.479092280975179 1.11475704289607 0.466021672600176 0.363722389449155 NA NA NA 0.114723870445867 99.0372124530328 a4251 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 14 28 -1.38629436111989 0.693147180559945 0.0369655989116912 -0.471839624104113 0.508805223015804 1.34941411252261 1.83545074656275 0.300558641281252 0.377056396768105 0.277209957264527 0.364006597095485 NA NA NA 0.31638994775793 99.0372124530328 a4252 gain_cnaBRCA48 1032 Afatinib ERBB2, EGFR 5 40 -0.693147180559945 NA 0.997870897719383 0.202046798479609 0.795824099239774 1.40172942285992 1.86716021046648 0.435145754232871 0.567744449293269 0.426221646529705 0.36406684692386 NA NA NA 0.294884143334666 99.0372124530328 a4253 gain_cnaBRCA63 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 39 2.30258509299405 NA 2.7237286637861 3.24658056505433 -0.522851901268234 2.53933144360381 1.03176935874525 0.402127800349004 0.205901400774294 0.506752693163986 0.364261254563003 NA NA NA 0.638574393949834 99.0372124530328 a4254 loss_cnaBRCA33 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 6 42 2.07944154167984 NA 3.61988939602444 3.15636260150081 0.463526794523623 0.541885465730876 1.21334284510063 0.399815507099588 0.855396248538305 0.382024583072546 0.364396241882038 NA NA NA 0.132273309322022 99.0372124530328 a4255 loss_cnaBRCA36_(FAT1,IRF2) 35 NVP-TAE684 ALK 3 11 0.693147180559945 NA 2.35691670620105 1.61379586187243 0.743120844328625 0.832283213805565 1.27239763176172 0.614042030975683 0.892870157660335 0.584031929782612 0.364408254818615 NA NA NA 0.281281608541023 99.0372124530328 a4256 CDH1_mut 1054 PD-0332991 CDK4, CDK6 4 38 1.38629436111989 0.693147180559945 3.52124438152822 2.81571109166177 0.705533289866445 1.57293652134361 1.45374041317485 0.482245442677191 0.448545303826867 0.48532274639433 0.364424507837246 NA NA NA 0.44415523966203 99.0372124530328 a4257 loss_cnaBRCA42 186 Bexarotene Retinioic acid X family agonist 3 44 2.07944154167984 NA 4.18690544991883 3.56468955397745 0.622215895941378 0.514756438296434 1.15927636980815 0.546567598899578 1.20875787003379 0.536727834834024 0.364564626003151 NA NA NA 0.153301305560891 99.0372124530328 a4258 loss_cnaBRCA38 287 KIN001-244 PDPK1 (PDK1) 4 45 2.99573227355399 NA 3.06519185044716 3.51480952553808 -0.449617675090917 0.92301815133437 0.942655100175982 0.477598288473262 0.487116829112106 0.476969439837518 0.364665445027247 NA NA NA 0.409821021857459 99.0372124530328 a4259 loss_cnaBRCA20 186 Bexarotene Retinioic acid X family agonist 3 44 2.07944154167984 NA 4.18654333411561 3.5647142436913 0.621829090424311 0.599266446228971 1.15739977684585 0.546221491768862 1.03765043802689 0.537263876202674 0.364865628971836 NA NA NA 0.202933662663884 99.0372124530328 a4260 gain_cnaBRCA15 260 NG-25 MAP3K7 (TAK1) 22 27 2.32630161961136 NA 3.39416322884087 3.05693465905896 0.337228569781915 1.56927221613801 0.994172945759715 0.262764632531178 0.214894883318483 0.339205136510947 0.364926916967809 NA NA NA 0.387717811137897 99.0372124530328 a4261 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1003 Camptothecin TOP1 6 39 -2.30258509299405 NA -1.97733360524535 -2.61419649615002 0.636862890904673 0.73625229468028 1.66580958923018 0.401561564504811 0.865006323927632 0.382314338338625 0.364930577314862 NA NA NA 0.134191077610661 99.0372124530328 a4262 BRCA1_mut 202 GSK-1904529A IGF1R 4 44 0.0237165266173161 NA 1.82537670087596 2.22279239981416 -0.397415698938208 1.27955951520585 0.790979814869147 0.477870069765112 0.310587897018822 0.502434691084947 0.364936592482359 NA NA NA 0.581941736672535 99.0372124530328 a4263 loss_cnaBRCA18 154 CHIR-99021 GSK3B 15 32 0.940007258491471 NA 3.09906739419014 3.35811004600599 -0.259042651815852 0.953984379881328 0.881443394871644 0.286350381284371 0.271537623968304 0.293884613944578 0.36501591761901 NA NA NA 0.382408436683334 99.0372124530328 a4264 loss_cnaBRCA7_(FAS,PTEN) 1061 SB590885 BRAF 4 38 1.6094379124341 NA 4.48518484515366 3.96209347023177 0.523091374921897 0.510928850584413 1.11982184588666 0.481640670947115 1.02380473195744 0.467120173484132 0.365020111902697 NA NA NA 0.141270357049036 99.0372124530328 a4265 BRCA1_mut 211 TL-2-105 CRAF 4 45 2.32630161961136 1.63315443905142 4.38365754755515 3.86523339776097 0.518424149794182 1.33528817915491 1.06772028120458 0.477032465936916 0.38824888730932 0.485543038677981 0.365228925370046 NA NA NA 0.499643615721908 99.0372124530328 a4266 gain_cnaBRCA19 333 T0901317 LXR 4 44 2.32630161961136 NA 4.4014145966209 4.76580180688505 -0.36438721026415 1.49797422503345 0.683261155003325 0.477336692265672 0.24325332450631 0.533305907405751 0.365467293935258 NA NA NA 0.661678124535976 99.0372124530328 a4267 gain_cnaBRCA19 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 4 43 2.77258872223978 NA 5.4581360416694 4.96929826814899 0.488837773520412 0.543254402173229 1.04918304172943 0.477722817444832 0.899832144138863 0.465922297709496 0.36564840554921 NA NA NA 0.177418668778973 99.0372124530328 a4268 gain_cnaBRCA48 1494 SN-38 TOP1 5 43 -2.99573227355399 NA -3.95384169986818 -3.22820092969747 -0.725640770170701 1.67818982490955 1.68138310829734 0.431644947809382 0.43239492898833 0.431573724387849 0.365724683431889 NA NA NA 0.402336741763976 99.0372124530328 a4269 ARID1A_mut 225 Genentech Cpd 10 AURKA, AURKB 5 44 2.32630161961136 NA 3.64172908182284 2.94719235200855 0.694536729814289 1.35027068470462 1.63367025931198 0.430989701928126 0.514368517129011 0.425138871112702 0.365782594427888 NA NA NA 0.331947708871584 99.0372124530328 a4270 CDH1_mut 1199 Tamoxifen ER 5 42 1.6094379124341 NA 4.23670023592455 3.825416649242 0.411283586682544 1.02847998993135 0.94389237422208 0.432149602910102 0.399894592708602 0.435731443451387 0.365863270582594 NA NA NA 0.434115231934402 99.0372124530328 a4271 loss_cnaBRCA17 106 XMD8-85 MAP2K5 (ERK5) 3 10 2.07944154167984 NA 2.64554814914891 3.39760757065394 -0.752059421505036 0.516563930485265 1.31713006858679 0.620726675063617 1.45588837532374 0.570983412679931 0.365955221110702 NA NA NA 0.17461820637358 99.0372124530328 a4272 gain_cnaBRCA64_(SDHC) 1036 PLX4720 BRAF 7 36 2.30258509299405 NA 4.21711012114804 4.67040842666566 -0.453298305517629 2.51989286189574 0.774143287940714 0.377637998304541 0.179887927924288 0.585548324940517 0.365956454977047 NA NA NA 0.653276383048479 99.0372124530328 a4273 TP53_mut 1494 SN-38 TOP1 38 10 -2.99573227355399 NA -3.19016442358654 -3.73556003800436 0.545395614417819 1.59196666403299 2.00648312153943 0.324422159118604 0.342592358709415 0.27181669686779 0.366100543026506 NA NA NA 0.44123082274345 99.0372124530328 a4274 loss_cnaBRCA28_(GPS2) 1199 Tamoxifen ER 4 43 1.6094379124341 NA 4.2847280982177 3.83051367569572 0.454214422521981 0.710674684889604 0.96664540209914 0.477253886645957 0.639131282117554 0.469887325316628 0.366114894448737 NA NA NA 0.301470887304559 99.0372124530328 a4275 loss_cnaBRCA7_(FAS,PTEN) 1026 17-AAG HSP90 4 39 0 NA -0.120241635979039 -0.975792805533216 0.855551169554177 1.05049330334436 1.82895456281299 0.479689347886061 0.814428009041499 0.467781533204583 0.366233537868607 NA NA NA 0.212839021058579 99.0372124530328 a4276 gain_cnaBRCA62 184 BMS-754807 IGF1R 9 39 0.940007258491471 NA 2.08625812223031 1.52085606986055 0.565402052369765 1.91081713272824 1.6225408476373 0.337303567244995 0.295895427503569 0.348467068297904 0.366459108826567 NA NA NA 0.428853389626665 99.0372124530328 a4277 loss_cnaBRCA57 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 5 38 0.693147180559945 NA 2.54204602632244 2.95662562340993 -0.414579597087491 0.844678374686672 0.965373360860013 0.434446633232818 0.490813556392132 0.429450007526786 0.36646203583355 NA NA NA 0.35335015664398 99.0372124530328 a4278 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1373 Dabrafenib BRAF 18 28 2.30258509299405 NA 4.48854763220088 4.0384729525355 0.45007467966538 1.17357109920466 1.86464716692952 0.275664095815843 0.383508659995463 0.241372570450693 0.366496256523823 NA NA NA 0.320551952361881 99.0372124530328 a4279 loss_cnaBRCA22_(SYNCRIP,ZNF292) 32 VX-680 AURKA, AURKB, AURKC, FLT3, ABL1, JAK2 3 9 0.693147180559945 NA 0.17849781566528 1.52868905037794 -1.35019123471266 3.03398793053554 1.85232204175622 0.630497360867055 0.445021953160616 0.728918192558202 0.366569202105161 NA NA NA 0.528897866439964 99.0372124530328 a4280 gain_cnaBRCA14_(RAD21) 206 Ruxolitinib JAK1, JAK2, TYK2 21 28 1.65632149833295 0.0237165266173161 4.46839721512781 4.29665788023323 0.171739334894572 0.608302819231147 0.683445663881068 0.263190550794353 0.282325396932467 0.25128454823946 0.366569520273982 NA NA NA 0.35867398704037 99.0372124530328 a4281 loss_cnaBRCA42 276 CAY10603 HDAC6 3 46 2.99573227355399 NA 0.670470527572931 1.20847904220724 -0.538008514634309 0.448531762294304 1.00778072456404 0.543203315059452 1.19948810733563 0.533854737961029 0.366631873139185 NA NA NA 0.155670640766101 99.0372124530328 a4282 loss_cnaBRCA18 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 14 29 1.6094379124341 NA 3.2469980624126 2.80055209708498 0.446445965327621 1.20814332820934 1.62173373051068 0.297042771286725 0.369530630102741 0.275289313484919 0.366714652750647 NA NA NA 0.319170364454582 99.0372124530328 a4283 gain_cnaBRCA10_(MDM2,NUP107) 254 AC220 FLT3 5 43 0.0237165266173161 NA 2.56411083145996 2.18418643972957 0.379924391730381 0.773369550319973 0.891685788530142 0.430739756670066 0.491258534258547 0.426074292780476 0.36672192544418 NA NA NA 0.350850177248472 99.0372124530328 a4284 loss_cnaBRCA60 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 3 44 2.32630161961136 NA 0.637406232555575 1.47008605177221 -0.832679819216637 0.679026645177375 1.55883193050743 0.544054944346533 1.22628445456529 0.534169080656168 0.366753479907196 NA NA NA 0.148923237905758 99.0372124530328 a4285 loss_cnaBRCA36_(FAT1,IRF2) 104 Bortezomib Proteasome 3 11 -3.91202300542815 NA -3.72923181762679 -4.80166430352587 1.07243248589908 1.87101316103127 1.73189568723285 0.610777677709665 0.573182759071545 0.619224641417383 0.366875618620297 NA NA NA 0.437053800991097 99.0372124530328 a4286 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 205 BMS-708163 g-secretase 6 42 2.32630161961136 0.940007258491471 5.13249072342487 4.86282077393316 0.269669949491711 0.574559977986403 0.689640381793843 0.397697306705063 0.469350389556882 0.391029812944342 0.366920159386253 NA NA NA 0.328837883427808 99.0372124530328 a4287 loss_cnaBRCA22_(SYNCRIP,ZNF292) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 19 30 1.63315443905142 NA 3.73993450897605 3.47324774469798 0.266686764278072 1.1246191772965 0.911693828099714 0.267055747200643 0.237135173987666 0.292517900262569 0.367028483557937 NA NA NA 0.391429208208112 99.0372124530328 a4288 NF1_mut 293 MP470 PDGFR 4 44 2.99573227355399 NA 4.25841718764091 3.46550953800144 0.792907649639467 0.926994911052341 1.70703358884799 0.475557387304155 0.8553527534896 0.464494462686331 0.367241268703138 NA NA NA 0.193861555166291 99.0372124530328 a4289 loss_cnaBRCA17 277 ABT-869 VEGFR and PDGFR family 10 38 0.0237165266173161 NA 2.56943462865673 2.72308972667944 -0.153655098022709 0.310789163987234 0.506711249488999 0.323631912785954 0.494403009588265 0.303239958018822 0.36725890344408 NA NA NA 0.242513086415226 99.0372124530328 a4290 NF1_mut 1166 QL-VIII-58 MTOR, ATR 3 23 2.30258509299405 NA -0.960895388800867 -1.59182685846696 0.630931469666094 0.79810714010536 1.14345224707207 0.563959781395074 0.790534801609222 0.551777716368706 0.367380624654323 NA NA NA 0.306133529284786 99.0372124530328 a4291 PTEN_mut 1032 Afatinib ERBB2, EGFR 7 38 -0.693147180559945 NA 0.869019194345878 0.183897159667372 0.685122034678506 1.3730842901912 1.89275017049183 0.374563037238245 0.498965751463884 0.361971719965808 0.367547883989755 NA NA NA 0.280636868717304 99.0372124530328 a4292 TP53_mut 254 AC220 FLT3 37 11 0.0237165266173161 NA 2.28692062595571 2.01131890048275 0.27560172547296 0.945105480402264 0.602757128202887 0.312452941153778 0.291609488240039 0.457235116065178 0.367653949208464 NA NA NA 0.259505810386842 99.0372124530328 a4293 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1019 Bosutinib SRC, ABL, TEC 6 39 0.693147180559945 NA 2.98533226995617 2.61294719382595 0.372385076130223 1.07354924602337 0.912583097708506 0.39924276061561 0.346872840262902 0.408056074088246 0.367679824527936 NA NA NA 0.450193172816128 99.0372124530328 a4294 loss_cnaBRCA57 1133 JNJ-26854165 MDM2 3 40 2.30258509299405 NA 3.41051402787234 2.93568841232078 0.474825615551558 0.729025100877698 0.877658433969224 0.545152037903272 0.651315866874679 0.541014131664128 0.367778207599478 NA NA NA 0.377827540833224 99.0372124530328 a4295 gain_cnaBRCA63 225 Genentech Cpd 10 AURKA, AURKB 7 42 2.32630161961136 NA 3.5308729994168 2.93259518813268 0.598277811284111 2.05320490883993 1.53637975577974 0.371229292890691 0.291387288579074 0.389407507508112 0.367819631218608 NA NA NA 0.48438454253315 99.0372124530328 a4296 loss_cnaBRCA33 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 37 -1.38629436111989 0.693147180559945 -0.949351205162634 -0.214790136874008 -0.734561068288626 3.1376114940916 1.44619019614841 0.433841126598802 0.234114730160783 0.507928397139573 0.368000123862875 NA NA NA 0.631556790396685 99.0372124530328 a4297 gain_cnaBRCA16 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 15 28 1.6094379124341 NA 3.2309408803062 2.79320966016599 0.437731220140208 1.36650303429415 1.56918525009379 0.291228114598524 0.320329490059502 0.278954457489353 0.368051550800844 NA NA NA 0.349283493105076 99.0372124530328 a4298 loss_cnaBRCA20 279 BIX02189 MAP2K5 (MEK5) 3 46 2.99573227355399 NA 5.48430664712598 4.99755491828998 0.486751728836001 0.691008465859911 0.906955113377383 0.541543219734525 0.704407764715695 0.536687782732048 0.368085578487998 NA NA NA 0.346799993039546 99.0372124530328 a4299 gain_cnaBRCA48 1017 Olaparib PARP1, PARP2 5 40 1.6094379124341 NA 3.7334666722468 4.11667702601417 -0.383210353767369 0.744959586576045 0.901545166349544 0.431473012331624 0.514404218259229 0.425059517893075 0.368090980698371 NA NA NA 0.333900438411076 99.0372124530328 a4300 gain_cnaBRCA47_(EGFR) 230 GSK429286A ROCK2 7 42 2.99573227355399 2.32630161961136 5.69034413811839 5.358030160665 0.332313977453391 0.54329724809366 0.936380227190534 0.370946087152374 0.611661440619156 0.354892134416858 0.368182013925022 NA NA NA 0.208561153558387 99.0372124530328 a4301 gain_cnaBRCA48 231 FMK RSK 5 44 2.99573227355399 2.32630161961136 5.81739123572088 5.56330224982734 0.254088985893536 0.282443572855991 0.613567985303267 0.428745027404187 0.899609728499958 0.414117085603721 0.368262940269621 NA NA NA 0.138333295824281 99.0372124530328 a4302 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 6 PHA-665752 MET 4 10 0.693147180559945 NA 3.16303515400509 2.74493599764023 0.418099156364856 0.720960962442384 0.767299497543274 0.553054969316109 0.579919271840282 0.544896950543456 0.368305130030546 NA NA NA 0.373546089304775 99.0372124530328 a4303 TP53_mut 55 A-770041 SRC family 9 3 1.63315443905142 NA 2.89070088972748 2.14765281060254 0.743048079124935 1.25534878197826 0.834473727444178 0.627992548507491 0.591905683736746 0.89043915307045 0.368397805197817 NA NA NA 0.293204268254005 99.0372124530328 a4304 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1194 SB-505124 TGFR1 (ALK5) 9 38 2.30258509299405 NA 4.63863731343148 4.32987424667457 0.308763066756914 0.846104201618715 0.931400520984364 0.336777242969373 0.364923216509511 0.33150407348988 0.368473904220905 NA NA NA 0.352122296020891 99.0372124530328 a4305 PTEN_mut 225 Genentech Cpd 10 AURKA, AURKB 9 40 2.32630161961136 NA 3.45882150051841 2.91889288482062 0.539928615697793 1.71198959362853 1.59028642327765 0.335015838708999 0.315380781347756 0.339516585059549 0.368474853168942 NA NA NA 0.404565318618896 99.0372124530328 a4306 loss_cnaBRCA57 1036 PLX4720 BRAF 5 38 2.30258509299405 NA 5.0553547479734 4.53625527547719 0.519099472496215 0.496964144002012 1.25310683494613 0.432406668226608 1.04454109770566 0.414249972963025 0.368694360301267 NA NA NA 0.10934368682561 99.0372124530328 a4307 NF1_mut 263 FR-180204 ERK 5 44 2.99573227355399 NA 5.07627226150884 5.38988632435392 -0.313614062845076 0.494192863160372 0.750509051832721 0.42831952654803 0.634598526655178 0.417868461518538 0.368734330654474 NA NA NA 0.251075713838114 99.0372124530328 a4308 loss_cnaBRCA33 59 WZ-1-84 BMX 4 8 2.32630161961136 NA 4.02149372002079 3.33209868613221 0.689395033888571 0.883033676765235 1.30740694704039 0.576411693518503 0.780712052131456 0.527299503378938 0.368745295915924 NA NA NA 0.309802431014656 99.0372124530328 a4309 gain_cnaBRCA8_(CHD4,WNK1) 1009 ATRA Retinoic acid and retinoid X receptor agonist 3 42 2.30258509299405 NA 3.5206205665181 4.14778160766208 -0.627161041143986 1.43505804527791 1.14035377320171 0.542654304107068 0.437028344050385 0.549970593233658 0.368921217074209 NA NA NA 0.53043851546125 99.0372124530328 a4310 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1023 GW 441756 NTRK1 5 40 0.693147180559945 NA 2.85685244684248 2.29709108390124 0.559761362941235 0.891565549363304 1.33466886902904 0.430639430053155 0.62784095161705 0.419400928522786 0.369008293530007 NA NA NA 0.25756571066239 99.0372124530328 a4311 gain_cnaBRCA31 5 Sunitinib PDGFRA, PDGFRB, KDR, KIT, FLT3 3 9 2.07944154167984 NA 3.90605830534588 3.03851888654672 0.867539418799154 1.77495340111609 1.26717663658485 0.626961652747607 0.488767433699188 0.684623906211884 0.369152298867825 NA NA NA 0.496274415401293 99.0372124530328 a4312 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1149 TW 37 BCL2, BCL2L1 5 38 1.6094379124341 NA 0.332851555089088 -0.204915268281209 0.537766823370297 2.26429422048178 1.07882146438521 0.431874117490419 0.237498651237945 0.498476199374428 0.369278569339642 NA NA NA 0.626914564898757 99.0372124530328 a4313 TP53_mut 275 I-BET BRD2, BRD3, BRD4 38 11 2.99573227355399 NA 4.13350843313386 3.71225376801552 0.421254665118332 1.33455886150368 1.4394820901706 0.310302279745801 0.315650869564264 0.292643213830056 0.369396758834932 NA NA NA 0.39848890082075 99.0372124530328 a4314 loss_cnaBRCA36_(FAT1,IRF2) 1091 BMS-536924 IGF1R 9 38 1.38629436111989 NA 2.72628877437718 3.09364750875647 -0.367358734379293 1.301102975339 1.04258619572037 0.336094348742867 0.282344089086092 0.352353345831007 0.36943701096532 NA NA NA 0.44737167686836 99.0372124530328 a4315 gain_cnaBRCA27_(CLTC,PPM1D) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 9 38 2.77258872223978 NA 5.28896179731122 4.94504509266535 0.343916704645872 0.710685314671724 1.07918379715219 0.336047564085941 0.483922627280869 0.318682235179419 0.369503051963254 NA NA NA 0.25825216796087 99.0372124530328 a4316 loss_cnaBRCA22_(SYNCRIP,ZNF292) 276 CAY10603 HDAC6 19 30 2.99573227355399 NA 1.336611314858 1.07352775139833 0.263083563459676 1.12612816739513 0.896130600522973 0.265594809242042 0.233617780885651 0.293577256826341 0.369632896356998 NA NA NA 0.395992483707824 99.0372124530328 a4317 loss_cnaBRCA34 207 AS601245 JNK 5 43 2.07944154167984 NA 1.7748146303242 2.3233386297582 -0.548523999434008 0.494135035541408 1.33277129575518 0.427927236922735 1.11006902967932 0.411566486448976 0.369831616710884 NA NA NA 0.0911796369687519 99.0372124530328 a4318 BRCA2_mut 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 6 43 1.63315443905142 NA 3.23084783167447 3.62490932607994 -0.394061494405474 0.750633433569653 1.02426135213156 0.394565819595984 0.524971946068944 0.384727485407316 0.369881688269788 NA NA NA 0.285562237635736 99.0372124530328 a4319 gain_cnaBRCA16 94 TGX221 PI3Kbeta 3 11 2.30258509299405 NA 3.16310101638057 3.93445954694787 -0.771358530567294 1.75020964441196 1.15198127389324 0.606706676857077 0.440723505912605 0.66959294221894 0.369969126792639 NA NA NA 0.532066311374621 99.0372124530328 a4320 gain_cnaBRCA27_(CLTC,PPM1D) 1199 Tamoxifen ER 10 37 1.6094379124341 NA 3.62740235189621 3.93451288996824 -0.30711053807203 1.12380291428955 0.90379191203569 0.322638812389424 0.273277933494397 0.3398022641963 0.370154361516561 NA NA NA 0.440364450731283 99.0372124530328 a4321 loss_cnaBRCA24 1218 JQ1 BRD2, BRD3, BRD4 3 43 0 NA 2.81233612736853 2.4332594820984 0.379076645270133 0.312272967534698 0.71438820585127 0.540664201687078 1.2139271876872 0.530631164071953 0.370181453275175 NA NA NA 0.152022906114415 99.0372124530328 a4322 loss_cnaBRCA57 1008 Methotrexate Dihydrofolate reductase (DHFR) 5 40 -1.6094379124341 NA 1.09806588263823 0.630723098424816 0.467342784213416 0.732984636341765 1.11818160139062 0.429496815532837 0.637588785688423 0.417948912441599 0.37026806916782 NA NA NA 0.252100609013954 99.0372124530328 a4323 BRCA2_mut 1170 CCT018159 HSP90 5 38 2.30258509299405 NA 2.89002278221208 3.40240809815728 -0.5123853159452 1.27800039025584 1.17958957765193 0.430739111145531 0.400927354836431 0.434375926722872 0.370525663462671 NA NA NA 0.434513226684595 99.0372124530328 a4324 PTEN_mut 151 QS11 ARFGAP 8 40 2.32630161961136 NA 3.32900192877585 3.84673948555154 -0.517737556775693 1.5549848403045 1.46489375190418 0.350069300757061 0.332953443246628 0.353430107885092 0.370771077715281 NA NA NA 0.406534328685382 99.0372124530328 a4325 ASH1L_mut 1019 Bosutinib SRC, ABL, TEC 3 42 0.693147180559945 NA 3.13320096457582 2.62898407821956 0.504216886356255 0.3839574532044 0.951553596618893 0.540516052773253 1.31321031053885 0.529888056908054 0.370793138640183 NA NA NA 0.129032148008474 99.0372124530328 a4326 loss_cnaBRCA17 54 CGP-082996 CDK4 3 9 1.63315443905142 NA 3.2841146588075 2.65074545012832 0.633369208679178 0.257098792296073 1.12621128118367 0.62471395802352 2.46352463589092 0.562389330724422 0.370801192861916 NA NA NA 0.148524879038357 99.0372124530328 a4327 loss_cnaBRCA38 219 AT-7519 CDK9 4 45 2.32630161961136 NA 0.888364811868541 1.74165700927721 -0.853292197408665 2.4308486119288 1.75958568001897 0.47146183538015 0.351026465910439 0.484939271271782 0.370806427346185 NA NA NA 0.537872272048105 99.0372124530328 a4328 PIK3CA_mut 1239 YK 4-279 RNA helicase A 14 28 2.30258509299405 NA 1.75825358671875 2.14120252686467 -0.382948940145918 1.52302795290382 1.16568140734713 0.296239591266427 0.251439206625054 0.328519385942199 0.370870226987731 NA NA NA 0.417372234243333 99.0372124530328 a4329 CDH1_mut 1009 ATRA Retinoic acid and retinoid X receptor agonist 4 41 2.30258509299405 NA 4.60479017825594 4.0573055733741 0.547484604881847 1.33541757246255 1.14120968619466 0.473676983214444 0.409972592971251 0.479740587119815 0.370890989526839 NA NA NA 0.479240479138414 99.0372124530328 a4330 loss_cnaBRCA28_(GPS2) 186 Bexarotene Retinioic acid X family agonist 4 43 2.07944154167984 NA 3.1122369377789 3.65018858078252 -0.537951643003623 1.301911021647 1.12611780884822 0.472433601774011 0.41320154300797 0.477704587190422 0.370932307572969 NA NA NA 0.475886747299604 99.0372124530328 a4331 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1114 Cetuximab EGFR 6 39 4.18661983833127 NA 6.58380596960758 6.23624337598316 0.347562593624422 0.362000032525828 0.923153406970311 0.39650798921694 0.960117575679013 0.376494947643734 0.370939371929053 NA NA NA 0.113983944889393 99.0372124530328 a4332 loss_cnaBRCA33 302 PI-103 PI3Ka, PRKDC (DNAPK) 6 42 2.32630161961136 NA 0.489543453285533 1.21970311742177 -0.730159664136235 1.41353483372983 1.89821598010254 0.394320914216968 0.516548758978649 0.384655735590631 0.370966469992478 NA NA NA 0.292528720271478 99.0372124530328 a4333 gain_cnaBRCA63 254 AC220 FLT3 7 41 0.0237165266173161 NA 2.50211593841183 2.17623803650704 0.325877901904791 0.533689674588537 0.923165356735168 0.369404779510176 0.610613091130226 0.35300057517028 0.371082894273554 NA NA NA 0.211149679708671 99.0372124530328 a4334 POLR2B_mut 185 OSI-906 IGF1R 3 45 0.940007258491471 NA 3.46226170857277 2.85557179286493 0.606689915707838 0.757640631900261 1.1404522154188 0.538553952666653 0.800762116184531 0.531973113389102 0.371134602085767 NA NA NA 0.297372660695928 99.0372124530328 a4335 gain_cnaBRCA16 83 JW-7-52-1 MTOR 3 9 0.182321556793955 NA -3.03509674366607 -1.68152151410269 -1.35357522956338 1.79139253472223 2.25362914144169 0.624032958674403 0.755599458704491 0.600620219481843 0.371301810901448 NA NA NA 0.344708715171162 99.0372124530328 a4336 loss_cnaBRCA29_(MAP2K4) 205 BMS-708163 g-secretase 7 41 2.32630161961136 0.940007258491471 5.11039751377389 4.86001546949572 0.25038204427817 0.707628135699078 0.673663072523676 0.369191713844966 0.353832799526566 0.371672508840641 0.371356469921491 NA NA NA 0.409125884738748 99.0372124530328 a4337 gain_cnaBRCA31 1024 CEP-701 FLT3, JAK2, NTRK1, RET 14 31 0.693147180559945 NA 0.912837676139759 0.495834646453229 0.41700302968653 1.58836154979138 1.3614360188744 0.290830750255981 0.262536592969843 0.306296457494416 0.371457331964457 NA NA NA 0.403820451025207 99.0372124530328 a4338 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 193 GW-2580 CSF1R (cFMS) 6 42 2.99573227355399 NA 5.72008744122182 5.42671764271447 0.293369798507356 0.390835641373014 0.777080142910856 0.393857414296527 0.750621917378725 0.377528368449134 0.371524159058651 NA NA NA 0.167787978671975 99.0372124530328 a4339 loss_cnaBRCA18 135 Gemcitabine DNA replication 15 32 0.0237165266173161 NA -0.805963400208512 -0.026439509200096 -0.779523891008416 1.94165557722978 3.0585493381748 0.282442448279867 0.401473824786468 0.254867195136895 0.371537516514176 NA NA NA 0.296655776258952 99.0372124530328 a4340 gain_cnaBRCA14_(RAD21) 303 PIK-93 PI4K, PI3K 21 28 2.99573227355399 NA 2.58016167962266 2.95005133970128 -0.369889660078622 1.37389183166715 1.45362526285123 0.26044103924104 0.269227643365328 0.254460120865743 0.37155417161329 NA NA NA 0.367916357665455 99.0372124530328 a4341 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 200 LAQ824 HDAC 9 39 0.0237165266173161 NA -2.30243341009062 -2.77262910214523 0.470195692054611 1.43132327440528 1.40432055411033 0.333696041103613 0.32850418941869 0.334820771994248 0.371562022733046 NA NA NA 0.39046046354848 99.0372124530328 a4342 gain_cnaBRCA27_(CLTC,PPM1D) 291 KIN001-266 MAP3K8 (COT) 9 40 2.99573227355399 NA 4.09876719435223 3.70660453224892 0.392162662103313 1.33313967091326 1.14420694906407 0.332762364792947 0.294164723066613 0.3427375287522 0.371677149667205 NA NA NA 0.431371088054677 99.0372124530328 a4343 gain_cnaBRCA12_(TERT) 135 Gemcitabine DNA replication 8 39 0.0237165266173161 NA 0.526820712796559 -0.439745666664185 0.966566379460744 1.65357871610721 2.91836556304233 0.350210908076958 0.584530007580284 0.331201269539763 0.371694271372207 NA NA NA 0.213363829002478 99.0372124530328 a4344 gain_cnaBRCA27_(CLTC,PPM1D) 1371 PLX4720 (rescreen) BRAF 10 37 2.30258509299405 NA 4.94891852848498 4.64180378034396 0.307114748141026 0.687115969600483 1.01120090477193 0.32151166370615 0.446962029305759 0.303712888993402 0.371813638790194 NA NA NA 0.274395508792442 99.0372124530328 a4345 ASH1L_mut 1023 GW 441756 NTRK1 3 42 0.693147180559945 NA 3.01368785304464 2.31254385788401 0.701143995160633 0.597135225040526 1.32476243790923 0.539349115713763 1.1741795924249 0.529260171557396 0.371817298030543 NA NA NA 0.162360914939108 99.0372124530328 a4346 gain_cnaBRCA8_(CHD4,WNK1) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 3 43 1.63315443905142 NA 2.73732943935704 1.88072977855271 0.85659966080433 1.44520162054556 1.59674128254628 0.538685535048108 0.592719831355409 0.536467410323564 0.371919395950214 NA NA NA 0.414568924738335 99.0372124530328 a4347 PTEN_mut 287 KIN001-244 PDPK1 (PDK1) 9 40 2.99573227355399 NA 3.22253702636835 3.53560907034217 -0.313072043973821 1.01837499748399 0.925147763037148 0.332465325741184 0.307423144467708 0.33840220609305 0.3721005818589 NA NA NA 0.414789173915945 99.0372124530328 a4348 gain_cnaBRCA58_(CCND1) 1248 FK866 NAMPT 9 35 0 NA 0.0759609639741565 -0.837563056339321 0.913524020313477 2.80628692226601 2.68726579815816 0.337051512075117 0.325527661859974 0.339945539045525 0.372289422233559 NA NA NA 0.396844198341727 99.0372124530328 a4349 PIK3CA_mut 299 OSI-027 MTORC1/2 16 32 2.99573227355399 NA 0.904393219041048 1.45125773592514 -0.546864516884092 2.16794868640407 1.88630113980118 0.275839786934413 0.252249751257335 0.28991368628539 0.372339979579989 NA NA NA 0.397795459256208 99.0372124530328 a4350 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 8 35 -1.38629436111989 0.693147180559945 -2.49415450605882 -2.15796409742175 -0.336190408637075 0.994557394558434 0.941974828085254 0.353453745218993 0.338030173498773 0.356899567391251 0.372357275318792 NA NA NA 0.404045060357121 99.0372124530328 a4351 PTEN_mut 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 8 38 1.63315443905142 NA 1.4761536632662 2.03352998657126 -0.557376323305062 1.58123426038662 1.59188984461438 0.350507186942887 0.352494464146497 0.350134982763258 0.372461017676236 NA NA NA 0.386252674805642 99.0372124530328 a4352 gain_cnaBRCA10_(MDM2,NUP107) 1001 AICAR AAPK1 (AMPK) agonist 3 42 7.60090245954208 NA 7.04532093380763 7.78799489297773 -0.742673959170105 0.698229180750917 1.40378939447685 0.538559479543307 1.06365356768875 0.529049415882557 0.372511349380746 NA NA NA 0.194582184493154 99.0372124530328 a4353 gain_cnaBRCA27_(CLTC,PPM1D) 37 Crizotinib MET, ALK 3 11 0.693147180559945 NA 3.02091865203646 2.551758072324 0.46916057971246 0.877123740561415 0.756148911754191 0.603329285411823 0.534885282448481 0.620460563282508 0.372549418832598 NA NA NA 0.462839236575872 99.0372124530328 a4354 NF1_mut 1049 PD-173074 FGFR1, FGFR3 4 39 0.693147180559945 NA 2.44788318595476 2.98800817491916 -0.540124988964402 0.899627592499861 1.1581449205554 0.473288813021099 0.600387308556774 0.466370813684854 0.372600446150191 NA NA NA 0.327810265411134 99.0372124530328 a4355 gain_cnaBRCA12_(TERT) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 9 38 2.77258872223978 NA 4.73463614747308 5.07633274657438 -0.341696599101295 1.11192347929494 1.00340323617858 0.333839033269943 0.307302260869571 0.340537668986033 0.372629231273796 NA NA NA 0.41614028867655 99.0372124530328 a4356 NF1_mut 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 4 44 0.246860077931526 2.32630161961136 -0.976610427984105 -0.200255638943311 -0.776354789040794 0.443919266842959 1.70404284077523 0.470109142659464 1.74886482076354 0.455595816292742 0.372707587005075 NA NA NA 0.0376051276196825 99.0372124530328 a4357 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1114 Cetuximab EGFR 13 32 4.18661983833127 NA 6.46726308059807 6.20755960728793 0.259703473310137 0.633104547502764 0.954346368117995 0.296255248309243 0.410206298998355 0.272127062024956 0.372736257138024 NA NA NA 0.29384096407964 99.0372124530328 a4358 NF1_mut 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 4 42 1.63315443905142 NA 1.25242442853705 2.00175407337356 -0.749329644836506 1.16328513761016 1.61703615073445 0.471212249780481 0.644149590336829 0.463396965179884 0.372747363218168 NA NA NA 0.299141081310725 99.0372124530328 a4359 gain_cnaBRCA16 328 SNX-2112 HSP90 16 32 0.940007258491471 NA 0.0429966527386518 0.604361608769763 -0.561364956031111 2.02727602287391 2.04241927586068 0.275517404859493 0.276906030405918 0.274852946535452 0.372894188961839 NA NA NA 0.374106506219761 99.0475875264609 a4360 gain_cnaBRCA27_(CLTC,PPM1D) 305 TPCA-1 IKK 9 40 2.99573227355399 NA 4.55184352588477 4.09428500460766 0.457558521277111 1.07963959698935 1.43319228867053 0.331701776472538 0.423806724533856 0.319258291364068 0.373190444932745 NA NA NA 0.298849251146988 99.0475875264609 a4361 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1248 FK866 NAMPT 9 35 0 NA -1.37598841681435 -0.464204644136563 -0.911783772677784 3.21541590084217 2.57728213970108 0.33639703753963 0.283566356824625 0.35377724411016 0.373209742335599 NA NA NA 0.447609528336637 99.0475875264609 a4362 gain_cnaBRCA15 273 CUDC-101 HDAC, EGFR 22 27 1.63315443905142 NA -0.249577320501768 0.154997185096233 -0.404574505598 1.80485359950364 1.34426633112222 0.258203360482634 0.224159181503288 0.300963057863879 0.373238386434257 NA NA NA 0.388395590720111 99.0475875264609 a4363 gain_cnaBRCA61_(NOTCH2) 230 GSK429286A ROCK2 3 46 2.99573227355399 2.32630161961136 5.85576770714323 5.37613853463758 0.479629172505646 0.372822075349076 0.912345938020099 0.535282537203257 1.28648276005804 0.525709769198403 0.373601170809222 NA NA NA 0.134754770397115 99.0475875264609 a4364 gain_cnaBRCA19 205 BMS-708163 g-secretase 4 44 2.32630161961136 0.940007258491471 4.60480232102924 4.92305017185511 -0.318247850825873 1.09378820566744 0.639252101060071 0.469222235008898 0.290959300143189 0.497844043528559 0.373602340584859 NA NA NA 0.604516446912622 99.0475875264609 a4365 loss_cnaBRCA18 263 FR-180204 ERK 16 33 2.99573227355399 NA 5.22292350071702 5.42332071417103 -0.200397213454008 0.867014724894497 0.659791339049239 0.273645135356096 0.231134728972906 0.30372816615444 0.37362072764198 NA NA NA 0.422091758372389 99.0475875264609 a4366 gain_cnaBRCA63 1016 Temsirolimus MTOR 5 39 -1.6094379124341 NA -1.1844219651851 -1.82357159936275 0.639149634177652 1.33332808209764 1.51275083355733 0.427070630185044 0.479364113573694 0.422508201614836 0.373744291082706 NA NA NA 0.362963665398373 99.0475875264609 a4367 gain_cnaBRCA58_(CCND1) 286 KIN001-236 TIE2 10 39 2.32630161961136 NA 4.73421059624891 4.49033306651418 0.243877529734725 0.690739842915895 0.782981126454655 0.318303995754308 0.353067123948168 0.311473063008561 0.373762881735836 NA NA NA 0.347744282363448 99.0475875264609 a4368 gain_cnaBRCA58_(CCND1) 1050 ZM-447439 AURKB 8 31 1.38629436111989 0.693147180559945 3.26107239201958 2.79162774337572 0.469444648643863 0.861621872553635 1.39997290539516 0.356955462239876 0.544838360767868 0.335324095798381 0.373870039111133 NA NA NA 0.250214533140179 99.0475875264609 a4369 gain_cnaBRCA15 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 22 25 2.32630161961136 NA 1.20319965196134 1.60502450529978 -0.401824853338445 1.65328941989799 1.41520691198358 0.262471655985012 0.243045681235436 0.283933642448962 0.37403234961102 NA NA NA 0.379172182502513 99.0475875264609 a4370 loss_cnaBRCA34 308 XL-880 MET 5 44 1.63315443905142 NA 1.23826949329005 1.91698598999173 -0.678716496701681 1.20705348896667 1.63451178604062 0.423515585384509 0.562291980351853 0.415241115113508 0.374083225765907 NA NA NA 0.297585208680234 99.0475875264609 a4371 loss_cnaBRCA34 1164 XMD8-92 MAP2K5 (ERK5) 3 23 2.30258509299405 NA 3.24564752422179 3.96781613403246 -0.722168609810667 0.71274954900317 1.33980966237909 0.55587074094061 1.01321510595225 0.539008360731117 0.37417653383037 NA NA NA 0.217072018708817 99.0475875264609 a4372 gain_cnaBRCA64_(SDHC) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 7 36 1.6094379124341 NA 3.31081755894021 2.78184755986661 0.528969999073604 1.79760810786123 1.35135831439526 0.37109856396453 0.294263247234107 0.391435782381908 0.37423395120879 NA NA NA 0.482755954102707 99.0475875264609 a4373 gain_cnaBRCA15 268 YM155 BIRC5 (Survivin) 22 27 1.63315443905142 NA -3.82220884087734 -3.41091583694675 -0.411293003930591 1.50676056916357 1.66552105226417 0.257615578659011 0.272965069797988 0.246945544982132 0.374318166843168 NA NA NA 0.369440544739685 99.0475875264609 a4374 gain_cnaBRCA27_(CLTC,PPM1D) 94 TGX221 PI3Kbeta 3 11 2.30258509299405 NA 4.36974261798629 3.60537547378267 0.764367144203618 1.29364337295109 1.26788635503934 0.60081582183301 0.590863881179189 0.602867237403072 0.37447783108879 NA NA NA 0.426689844096269 99.0475875264609 a4375 BRCA1_mut 225 Genentech Cpd 10 AURKA, AURKB 4 45 2.32630161961136 NA 3.71061714549676 2.95650311812229 0.754114027374465 1.70608484709233 1.60538340778739 0.467812925831934 0.442014374994125 0.469740763307014 0.374489265292465 NA NA NA 0.449124829264643 99.0475875264609 a4376 POLR2B_mut 1022 AZD7762 CHEK1, CHEK2 3 42 0.693147180559945 NA 1.71597170752638 0.846806326910706 0.86916538061567 2.15283770872914 1.59028402471562 0.536262074380953 0.403730098693206 0.546547262694851 0.374535377915863 NA NA NA 0.558951698541227 99.0475875264609 a4377 gain_cnaBRCA15 60 BI-2536 PLK1, PLK2, PLK3 6 6 -1.36257783450257 NA -1.91737477765547 -1.07833710562209 -0.839037672033383 1.70188290060165 1.4127175552993 0.536469960671861 0.493005524491002 0.593917495316765 0.374674450871465 NA NA NA 0.375396764988342 99.0475875264609 a4378 gain_cnaBRCA15 83 JW-7-52-1 MTOR 6 6 0.182321556793955 NA -2.60202452783787 -1.4378061151492 -1.16421841268868 2.99786746959059 0.658641298489282 0.536414551958299 0.388348859480326 1.76760615430437 0.374721814736336 NA NA NA 0.39191697157549 99.0475875264609 a4379 gain_cnaBRCA63 1058 GDC0941 PI3K (class 1) 5 38 1.38629436111989 0.693147180559945 1.86832204957247 1.27727632217346 0.591045727399002 0.994748256323755 1.42057791282554 0.426806402242814 0.594166135644512 0.416060057011169 0.374867692773689 NA NA NA 0.280195849018537 99.0475875264609 a4380 TP53_mut 119 Lapatinib ERBB2, EGFR 9 4 0.693147180559945 NA 1.05976216154153 2.302788306678 -1.24302614513647 2.58648658621856 0.725933038885244 0.55539231214701 0.480584802472829 1.71231515656773 0.375197045097474 NA NA NA 0.212790562926258 99.0475875264609 a4381 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1248 FK866 NAMPT 8 36 0 NA -1.42759397559454 -0.478064069204236 -0.949529906390304 2.69025249886216 2.71472332343611 0.350294702566297 0.352951965212152 0.349770416083675 0.375255668808724 NA NA NA 0.387686333117412 99.0475875264609 a4382 loss_cnaBRCA23 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 46 3.68887945411394 NA 2.86166957872169 3.49844485845827 -0.636775279736577 1.50772036014655 1.17805856798151 0.533338344397805 0.422343092637338 0.540529390510379 0.375324673969175 NA NA NA 0.542698366755633 99.0475875264609 a4383 gain_cnaBRCA9_(KRAS) 197 Bryostatin 1 PRKC 4 44 -4.8283137373023 NA -3.22038068170603 -2.7692060359437 -0.451174645762327 1.52493735487426 0.913644932842369 0.467352644739693 0.295864380474521 0.493818363725516 0.375492963826166 NA NA NA 0.598881721718124 99.0475875264609 a4384 gain_cnaBRCA27_(CLTC,PPM1D) 333 T0901317 LXR 9 39 2.32630161961136 NA 4.53013731015885 4.78281287430759 -0.252675564148742 0.975792967300192 0.710980815350846 0.330874344119554 0.258943825807477 0.355390129653575 0.37558494211467 NA NA NA 0.480182997980756 99.0475875264609 a4385 ASH1L_mut 186 Bexarotene Retinioic acid X family agonist 3 44 2.07944154167984 NA 3.03515269857215 3.64321815066018 -0.608065452088021 0.535273150313389 1.15933461567275 0.533913783999997 1.13599094543041 0.524495209465618 0.375673598651709 NA NA NA 0.172820306603739 99.0475875264609 a4386 loss_cnaBRCA17 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 11 38 3.68887945411394 NA 3.176045669815 3.54149920677053 -0.365453536955535 1.27687613272064 1.17055033557623 0.306083682611517 0.286209075093967 0.312206597058153 0.375885036490422 NA NA NA 0.407788030078555 99.0475875264609 a4387 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 59 WZ-1-84 BMX 3 9 2.32630161961136 NA 4.11670517060019 3.37696098414892 0.739744186451271 1.39528213193346 1.14274547998715 0.61772968282795 0.530175345559824 0.647339411449334 0.375958484326653 NA NA NA 0.468137021833318 99.0475875264609 a4388 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 178 BAY 61-3606 SYK 6 42 2.07944154167984 NA 2.54796727865713 3.17400789923224 -0.626040620575112 1.28269232875909 1.63980900539691 0.390093885814765 0.488067642207512 0.381776547460527 0.376072354312814 NA NA NA 0.3148899153942 99.0475875264609 a4389 BRCA1_mut 303 PIK-93 PI4K, PI3K 4 45 2.99573227355399 NA 3.39971842318212 2.73746575757741 0.662252665604714 0.854670411658002 1.45103896152536 0.46621967942454 0.774863218114676 0.456398954931259 0.376104623616368 NA NA NA 0.228681744244718 99.0475875264609 a4390 loss_cnaBRCA33 157 JNK-9L JNK 6 41 1.63315443905142 NA -0.303628784418522 0.108450114739849 -0.412078899158371 0.320682579460795 1.11282844891688 0.390738326418969 1.28500556485249 0.370298674121289 0.376114373324341 NA NA NA 0.0688148605549144 99.0475875264609 a4391 loss_cnaBRCA38 346 THZ-2-102-1 CDK7 4 44 0.916290731874155 2.99573227355399 -2.42247597376884 -1.23631051730698 -1.18616545646186 2.50465196776996 2.544492468126 0.466642784004594 0.473584941830451 0.466169765216662 0.376212406572478 NA NA NA 0.421799648594422 99.0475875264609 a4392 loss_cnaBRCA34 163 JQ1 BRD4 5 42 0.940007258491471 NA -0.234232479098157 0.381410699784594 -0.615643178882751 1.08895872179293 1.48770247285879 0.422632962440064 0.565350335657461 0.41382143951117 0.376420012247252 NA NA NA 0.296771912160223 99.0475875264609 a4393 loss_cnaBRCA33 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 41 1.38629436111989 NA 2.3004452770753 2.92667802041947 -0.626232743344165 2.91784872868626 1.24782263154976 0.423217588109968 0.214621387732503 0.501860382646213 0.376486467867308 NA NA NA 0.658779480103199 99.0475875264609 a4394 gain_cnaBRCA63 263 FR-180204 ERK 7 42 2.99573227355399 NA 5.1290660230142 5.39602136709565 -0.266955344081447 1.40746888114857 0.57009705825359 0.36449398773249 0.189670512547032 0.468262974201667 0.376500028965123 NA NA NA 0.637243009363483 99.0475875264609 a4395 loss_cnaBRCA42 134 Etoposide TOP2 3 44 2.77258872223978 NA 1.40117774531829 2.55046014816249 -1.1492824028442 2.04607760706944 2.16179280609166 0.532869126089372 0.561700298597321 0.531633928841683 0.376600281170613 NA NA NA 0.435507161649619 99.0475875264609 a4396 PTEN_mut 167 OSU-03012 PDPK1 (PDK1) 8 40 2.77258872223978 NA 1.90715124221307 2.31614458465855 -0.408993342445486 1.32277350498405 1.15593244574921 0.345772222914145 0.309193781780817 0.353821145819987 0.376621860067121 NA NA NA 0.435776898351988 99.0475875264609 a4397 MACF1_mut 1230 IOX2 EGLN1 3 44 -2.30258509299405 NA 0.57523268195111 0.227251123470066 0.347981558481043 0.29393133009289 0.665129652949929 0.532792928293923 1.1838872649985 0.523178536602155 0.376667930782739 NA NA NA 0.159737115622065 99.0475875264609 a4398 loss_cnaBRCA23 272 AR-42 HDAC 3 46 1.63315443905142 NA -0.620936057237138 0.191723273191805 -0.812659330428943 1.07550152140067 1.54557040425495 0.531665844132939 0.755609652109635 0.525798972464597 0.376811375043039 NA NA NA 0.319656981720894 99.0475875264609 a4399 gain_cnaBRCA47_(EGFR) 254 AC220 FLT3 7 41 0.0237165266173161 NA 2.49881859092099 2.17680099827377 0.322017592647224 0.704773626191105 0.905994456642106 0.36495263672619 0.456909255227872 0.355429981151011 0.376826275381538 NA NA NA 0.311426468285441 99.0475875264609 a4400 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 3 11 1.38629436111989 NA 2.29612563575698 1.81816312792769 0.477962507829295 0.690004581354194 0.820042416793326 0.597573428077488 0.692694687463165 0.582850957513038 0.376975777854682 NA NA NA 0.369554216719154 99.0475875264609 a4401 BRCA2_mut 1248 FK866 NAMPT 5 39 0 NA -1.66958592219766 -0.520080222695398 -1.14950569950226 2.89269492099932 2.69100428823338 0.424037355628425 0.397382278773162 0.427166060094577 0.377115708113581 NA NA NA 0.438181007684298 99.0475875264609 a4402 loss_cnaBRCA17 266 Zibotentan, ZD4054 Endothelin A Receptor 11 38 2.99573227355399 NA 5.62558822600191 5.77574893038488 -0.150160704382971 0.495533639727177 0.49100170980225 0.305223638286405 0.303028275669931 0.305825216868283 0.377216661383408 NA NA NA 0.388170797015209 99.0475875264609 a4403 BRCA2_mut 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 5 41 2.30258509299405 NA 1.03880486141593 1.45882979990346 -0.420024938487535 0.91519292018764 1.00164843260546 0.422517968441733 0.458946883463018 0.419333695151877 0.377268884806524 NA NA NA 0.379848817411715 99.0475875264609 a4404 loss_cnaBRCA7_(FAS,PTEN) 1039 SL 0101-1 RSK, AURKB, PIM3 4 39 2.30258509299405 NA 5.05821914010314 4.60683956110994 0.451379578993203 0.4062266408727 0.993940714992936 0.468637138949322 1.1111520850122 0.45413128990939 0.377272036164679 NA NA NA 0.120403848016145 99.0475875264609 a4405 loss_cnaBRCA22_(SYNCRIP,ZNF292) 60 BI-2536 PLK1, PLK2, PLK3 3 9 -1.36257783450257 NA -2.22060867049802 -1.25693836535236 -0.963670305145661 1.59936322552997 1.55593310647823 0.615875705737329 0.602533739530203 0.61935201528482 0.377336047630698 NA NA NA 0.423077009437548 99.0475875264609 a4406 PIK3CA_mut 1028 VX-702 p38 16 29 0.693147180559945 NA 3.5491062005997 3.35936949040078 0.189736710198924 0.647261029236918 0.701454826257092 0.277783313859681 0.293137855715818 0.270490276916824 0.377364032905013 NA NA NA 0.367612594080057 99.0475875264609 a4407 loss_cnaBRCA29_(MAP2K4) 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 3 23 2.30258509299405 NA 3.29158237112575 2.61327654804909 0.678305823076659 1.02902815755074 1.24571973868392 0.551862040098913 0.659171294876071 0.544509171696419 0.37757485586225 NA NA NA 0.376561459325007 99.0475875264609 a4408 BRCA2_mut 305 TPCA-1 IKK 6 43 2.99573227355399 NA 3.70837823342437 4.24390052364472 -0.535522290220352 1.34559297317399 1.38364239615945 0.388159633550922 0.397982377209626 0.387038075522109 0.377637219397842 NA NA NA 0.394978469028229 99.0475875264609 a4409 CDH1_mut 1529 MLN4924 NEDD8-activating enzyme 3 34 0 NA 1.20835860817318 0.295173213306484 0.913185394866692 1.00123305539379 1.73026263550959 0.538097985420607 0.912060773410575 0.527772706943847 0.377729259438874 NA NA NA 0.249706367540538 99.0475875264609 a4410 BRCA2_mut 205 BMS-708163 g-secretase 6 42 2.32630161961136 0.940007258491471 4.66586151251179 4.92948208977789 -0.263620577266094 0.866984420918476 0.651620510874797 0.388620390754427 0.304066106501448 0.404561509140013 0.377862692454717 NA NA NA 0.501363110933864 99.0475875264609 a4411 loss_cnaBRCA17 257 NPK76-II-72-1 PLK3 11 38 2.32630161961136 NA 3.10482958253397 3.58726129338107 -0.482431710847109 1.79568627272901 1.52069215180244 0.304718056659377 0.268661468416712 0.317244821889357 0.378000863516497 NA NA NA 0.43063706302424 99.0475875264609 a4412 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1003 Camptothecin TOP1 8 37 -2.30258509299405 NA -2.07614492863455 -2.62725690681747 0.551111978182917 1.23353922070085 1.64669098630907 0.347314395764367 0.446772967518451 0.334678444689972 0.378013220103546 NA NA NA 0.302426152385604 99.0475875264609 a4413 PIK3CA_mut 1052 RO-3306 CDK1 15 28 1.6094379124341 NA 3.74847031132655 3.40631785136275 0.342152459963799 1.01782734405863 1.2841629940538 0.285154511165836 0.336159626641047 0.266440055933791 0.378027123055876 NA NA NA 0.345402436890807 99.0475875264609 a4414 gain_cnaBRCA9_(KRAS) 166 FTI-277 Farnesyl transferase (FNTA) 4 43 0.0237165266173161 NA 1.89773914743849 2.27663431321618 -0.378895165777695 1.61462115869916 0.723959160746743 0.465339814936237 0.234665056713958 0.523365386228245 0.378095465779115 NA NA NA 0.672532792864275 99.0475875264609 a4415 gain_cnaBRCA9_(KRAS) 179 5-Fluorouracil DNA antimetabolite 4 45 3.46573590279973 NA 3.35261840248591 4.10270853566 -0.750090133174096 1.37298317534682 1.63201652406628 0.463957122127716 0.546321431058048 0.459609398626182 0.378406197843083 NA NA NA 0.364144550963149 99.0475875264609 a4416 gain_cnaBRCA63 1527 GDC0941 (rescreen) PI3K 5 40 1.38629436111989 NA 1.41399590551385 0.926488333344836 0.487507572169012 0.891552411047475 1.17860559447681 0.422114934596882 0.546807530469515 0.413630797659177 0.378473387244565 NA NA NA 0.311034933836969 99.0475875264609 a4417 TP53_mut 185 OSI-906 IGF1R 38 10 0.940007258491471 NA 2.96768543017009 2.61154694581769 0.356138484352396 1.1395950832194 1.07268425231086 0.316057211084666 0.312513180862706 0.332006817090096 0.378481483238995 NA NA NA 0.371353291431625 99.0475875264609 a4418 gain_cnaBRCA27_(CLTC,PPM1D) 1219 PFI-1 BRD2, BRD3, BRD4 10 37 2.30258509299405 NA 2.92368144061703 3.2397242034694 -0.316042762852368 1.28123312029655 0.912120170088792 0.317013960492138 0.246670771966321 0.346492461428194 0.378482079789934 NA NA NA 0.478988257311095 99.0475875264609 a4419 gain_cnaBRCA10_(MDM2,NUP107) 163 JQ1 BRD4 4 43 0.940007258491471 NA 0.93545416086192 0.258285357023592 0.677168803838328 2.20046971947007 1.38852508619845 0.46483232987283 0.307738296894814 0.487689283088362 0.378611268290514 NA NA NA 0.585464888773882 99.0475875264609 a4420 loss_cnaBRCA7_(FAS,PTEN) 173 FH535 unknown 4 44 3.46573590279973 NA 1.02879886588034 1.62247072513517 -0.593671859254828 1.43965971371842 1.26694817777378 0.46419667210163 0.412369571502048 0.468584169163097 0.378698262290688 NA NA NA 0.476787218679816 99.0475875264609 a4421 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1192 GSK269962A ROCK1, ROCK2 6 40 1.6094379124341 NA 3.16286230470456 2.59370583812252 0.569156466582035 1.53075838335787 1.45316536147044 0.389249287018559 0.371813391825778 0.391666689609305 0.378780294141992 NA NA NA 0.423367385282967 99.0475875264609 a4422 loss_cnaBRCA29_(MAP2K4) 276 CAY10603 HDAC6 7 42 2.99573227355399 NA 0.867516445962487 1.22687696196463 -0.359360516002143 0.59368978605199 1.03630323681023 0.362671677494866 0.605300149075959 0.346771585031678 0.378870855826023 NA NA NA 0.214538890121666 99.0475875264609 a4423 gain_cnaBRCA16 1527 GDC0941 (rescreen) PI3K 15 30 1.38629436111989 NA 1.19713975612095 0.872413883984946 0.324725872136006 1.18401012119891 1.14063339793035 0.28116378217161 0.274259371876985 0.284689079528281 0.378886861317615 NA NA NA 0.387706920137384 99.0475875264609 a4424 CDH1_mut 171 AKT inhibitor VIII AKT1, AKT2, AKT3 4 43 0.940007258491471 NA 2.42079245650431 1.83915788738733 0.581634569116982 0.713900023538508 1.28193269645332 0.464524708962161 0.814728323209822 0.453716931260254 0.378924148821565 NA NA NA 0.211925033423641 99.0475875264609 a4425 loss_cnaBRCA17 1023 GW 441756 NTRK1 8 37 0.693147180559945 NA 2.72987775156952 2.27915901561368 0.450718735955839 1.12879956618597 1.33113222205096 0.346615661351283 0.399290316418835 0.33859802090989 0.378964739344332 NA NA NA 0.34218967620051 99.0475875264609 a4426 PIK3CA_mut 155 AP-24534 ABL 16 31 -0.669430653942629 NA 1.64985967838813 1.3398114164112 0.31004826197693 1.17296109456388 1.11346195385282 0.2734975001292 0.264329536089352 0.278454293749415 0.379009943827205 NA NA NA 0.389542529014538 99.0475875264609 a4427 loss_cnaBRCA38 282 EKB-569 EGFR 4 43 0.916290731874155 2.99573227355399 0.679908842947515 1.66161709011776 -0.981708247170249 1.01036139213115 2.17126305606288 0.464428371994608 0.971640696899089 0.452136946018123 0.379022166740719 NA NA NA 0.154807394480628 99.0475875264609 a4428 TP53_mut 292 Masitinib KIT 37 11 2.99573227355399 NA 4.08637386549429 3.75453466213184 0.331839203362453 1.15335706196717 0.813274656951044 0.304858485726072 0.287715933170311 0.408028456962515 0.379310854845796 NA NA NA 0.295368486456252 99.0475875264609 a4429 gain_cnaBRCA15 292 Masitinib KIT 22 26 2.99573227355399 NA 3.85870757945499 4.13862105995112 -0.279913480496126 1.18480280468951 1.00047246654888 0.257154635759382 0.236253222382843 0.279781293194091 0.379314250586811 NA NA NA 0.386556198260249 99.0475875264609 a4430 gain_cnaBRCA31 94 TGX221 PI3Kbeta 4 10 2.30258509299405 NA 4.26021272289131 3.57275071740031 0.687462005491 1.67256586445216 1.1083939877018 0.539992501429857 0.411022381899547 0.620232528431896 0.379344795321488 NA NA NA 0.489567466350682 99.0475875264609 a4431 loss_cnaBRCA17 230 GSK429286A ROCK2 11 38 2.99573227355399 2.32630161961136 5.19436382556636 5.46662299035602 -0.272259164789658 0.765789084243543 0.928324423466372 0.303787950143953 0.355527612486929 0.293280191609136 0.379446246858145 NA NA NA 0.335502303192592 99.0475875264609 a4432 loss_cnaBRCA34 140 Vinorelbine Microtubules 5 42 -2.74887219562247 NA -4.21682180112481 -3.52636417699119 -0.690457624133626 1.01242001945792 1.69379422669627 0.419808057654162 0.681987328246747 0.407639613626713 0.379590699464428 NA NA NA 0.227941988026391 99.0475875264609 a4433 loss_cnaBRCA57 1203 QL-XII-61 BTK 5 18 2.30258509299405 NA 4.75993551367408 4.07667646151292 0.683259052161167 0.664367305876556 1.64299380692926 0.453562411622211 1.02843569531117 0.415862220100618 0.379777723648574 NA NA NA 0.179191208783713 99.0475875264609 a4434 gain_cnaBRCA63 262 VX-11e ERK 7 42 1.63315443905142 NA 3.36436228066969 3.84555355525906 -0.48119127458937 2.77798702117501 0.946963361520536 0.361947536796185 0.17321581091687 0.508141385551308 0.379815590751937 NA NA NA 0.665267358776995 99.0475875264609 a4435 loss_cnaBRCA22_(SYNCRIP,ZNF292) 163 JQ1 BRD4 17 30 0.940007258491471 NA 0.0655943677987401 0.457766091429452 -0.392171723630712 1.24298999992539 1.56239362903465 0.269187344025619 0.315506740725389 0.251006991031462 0.37993954116837 NA NA NA 0.350396159809671 99.0475875264609 a4436 MLL3_mut 257 NPK76-II-72-1 PLK3 3 46 2.32630161961136 NA 2.6940121538793 3.53015256727645 -0.836140413397149 1.06801301934864 1.6023780686839 0.528094035647324 0.782893465013276 0.521812192601904 0.379998921244645 NA NA NA 0.306036978272752 99.0475875264609 a4437 PIK3CA_mut 200 LAQ824 HDAC 17 31 0.0237165266173161 NA -2.92787196813435 -2.55098749084501 -0.37688447728934 0.891617901455863 1.61933486340806 0.267389754102695 0.422697297434192 0.232740297146537 0.380230659518079 NA NA NA 0.303825405311439 99.0475875264609 a4438 loss_cnaBRCA34 1170 CCT018159 HSP90 3 40 2.30258509299405 NA 3.93057056232637 3.29874774885145 0.631822813474916 0.983693415020948 1.1996453615616 0.530934322103801 0.642296475534973 0.526674660461706 0.38028127936751 NA NA NA 0.38349276314293 99.0475875264609 a4439 gain_cnaBRCA64_(SDHC) 256 JW-7-24-1 LCK 8 40 2.32630161961136 NA 1.50514547585004 1.9040538591976 -0.398908383347569 0.586739979590837 1.23811278066419 0.343066526591075 0.679872511202913 0.322190667584881 0.380335881148682 NA NA NA 0.175948889546174 99.0475875264609 a4440 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 309 Y-39983 ROCK 6 43 2.99573227355399 NA 4.56844135955526 4.98612598320982 -0.417684623654563 1.24118899049434 1.06193793017432 0.385880686617125 0.336519761980975 0.393323010494594 0.380420953975306 NA NA NA 0.461905791281533 99.0475875264609 a4441 loss_cnaBRCA28_(GPS2) 1042 BIRB 0796 p38, JNK2 3 40 2.30258509299405 NA 4.822020032775 4.3324387187462 0.489581314028801 0.473196910700775 0.940163248861286 0.530491456562229 1.03462491609204 0.52074074861124 0.380675038740041 NA NA NA 0.204209682026195 99.0475875264609 a4442 CDH1_mut 170 Shikonin unknown 4 43 2.77258872223978 NA -0.498311759219064 0.0502982179320624 -0.548609977151126 1.43349136725591 1.16586169226461 0.462733684115168 0.382708950805413 0.470561800590162 0.380749060785451 NA NA NA 0.50582485642124 99.0475875264609 a4443 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 176 IPA-3 PAK1, PAK2, PAK3 7 40 3.46573590279973 NA 4.96231193991779 4.41538176426869 0.546930175649109 1.87997572957188 1.44236767725397 0.362668908526437 0.290924061968427 0.379189151472371 0.380755581406789 NA NA NA 0.486524798152289 99.0475875264609 a4444 gain_cnaBRCA62 1133 JNJ-26854165 MDM2 7 36 2.30258509299405 NA 3.23583189803792 2.91689598028285 0.318935917755069 1.11561107090596 0.822358581530348 0.365979061704464 0.285884504082653 0.387830716330037 0.380797265212183 NA NA NA 0.494253296301233 99.0475875264609 a4445 POLR2B_mut 173 FH535 unknown 3 45 3.46573590279973 NA 0.940366881995776 1.61517348274403 -0.674806600748258 0.622885825314554 1.30100711987113 0.527595920471029 1.08335520463559 0.518680175105501 0.380863380116198 NA NA NA 0.188368967937401 99.0475875264609 a4446 gain_cnaBRCA16 1011 ABT-263 BCL2, BCL2L1, BCL2L2 14 29 0.693147180559945 NA 2.00647065608024 1.52528043950979 0.481190216570449 1.17320057473309 1.85528798114913 0.288229985099824 0.410151705457459 0.259361469194884 0.380964920372781 NA NA NA 0.308194992475646 99.0475875264609 a4447 MACF1_mut 1054 PD-0332991 CDK4, CDK6 3 39 1.38629436111989 0.693147180559945 3.60437359752806 2.82740713376093 0.776966463767134 1.55447351862779 1.45912540674243 0.530700188781985 0.499826117625342 0.53248779040984 0.381039456253984 NA NA NA 0.480801406620143 99.0475875264609 a4448 PIK3CA_mut 1042 BIRB 0796 p38, JNK2 15 28 2.30258509299405 NA 4.53682662004377 4.27540034098273 0.261426279061046 0.836354573487201 0.964724376206782 0.283265936398116 0.312578285990621 0.270985460208804 0.381163893730875 NA NA NA 0.361769913880437 99.0475875264609 a4449 loss_cnaBRCA20 235 QL-XII-47 BTK, BMX 3 46 2.32630161961136 NA 0.964967030289939 1.75653866424654 -0.791571633956598 1.14598535949203 1.51681737574565 0.526695293967932 0.690734508429906 0.521863506190039 0.381251831705072 NA NA NA 0.3545973144601 99.0475875264609 a4450 PIK3CA_mut 306 TG101348 JAK2 16 32 2.32630161961136 NA 3.45622548965543 3.10922065265797 0.347004836997456 1.28787059357434 1.27920228658904 0.270667136797457 0.269440764257519 0.271266585930466 0.381295928943041 NA NA NA 0.384825831899356 99.0475875264609 a4451 MLL3_mut 208 SB-715992 KIF11 3 46 -2.05572501506252 NA -2.08337951697705 -1.18488970312725 -0.898489813849795 2.1855213720425 1.68217058238749 0.526474279354928 0.411110056091606 0.534125268422289 0.381450042785291 NA NA NA 0.552416103255514 99.0475875264609 a4452 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1013 Nilotinib ABL 7 33 0.693147180559945 NA 3.49360581600133 3.14124407830949 0.352361737691839 0.822627435685953 0.979751668177806 0.368325022822762 0.428336963254842 0.359643927269019 0.381653139533514 NA NA NA 0.343884183112646 99.0475875264609 a4453 loss_cnaBRCA24 344 THZ-2-49 CDK9 3 46 2.99573227355399 NA 1.05797038782765 1.83270790456315 -0.774737516735495 0.830101914249694 1.49477645347312 0.526095863688439 0.9333040960829 0.518296575341007 0.381789566345738 NA NA NA 0.240333186114104 99.0475875264609 a4454 loss_cnaBRCA18 6 PHA-665752 MET 6 8 0.693147180559945 NA 3.07659216400909 2.70524345104602 0.371348712963077 0.37130471880209 0.940775028783146 0.490262627209084 1.0001184853269 0.394726370919306 0.381858083999948 NA NA NA 0.334512885889868 99.0475875264609 a4455 PIK3CA_mut 6 PHA-665752 MET 4 10 0.693147180559945 NA 3.15490789945773 2.74818689945918 0.406720999998548 0.328535908999453 0.853821303281049 0.536955440479796 1.2379803511805 0.476353773834885 0.381944177110422 NA NA NA 0.222449603921914 99.0475875264609 a4456 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 86 A-443654 AKT1, AKT2, AKT3 3 9 0.0237165266173161 NA -1.84444546853702 -1.08535764872159 -0.759087819815424 1.6005538636073 1.1389140299907 0.609703257241294 0.474265713310396 0.666501421377364 0.38194825562165 NA NA NA 0.507910241713193 99.0475875264609 a4457 gain_cnaBRCA27_(CLTC,PPM1D) 86 A-443654 AKT1, AKT2, AKT3 3 9 0.0237165266173161 NA -1.84444546853702 -1.08535764872159 -0.759087819815424 1.6005538636073 1.1389140299907 0.609703257241294 0.474265713310396 0.666501421377364 0.38194825562165 NA NA NA 0.507910241713193 99.0475875264609 a4458 gain_cnaBRCA47_(EGFR) 286 KIN001-236 TIE2 7 42 2.32630161961136 NA 4.77677628308685 4.50065860892701 0.276117674159847 0.844810001062013 0.754241107997273 0.36027914095879 0.326839968528709 0.366086747635672 0.381997911921103 NA NA NA 0.440984934015721 99.0475875264609 a4459 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1009 ATRA Retinoic acid and retinoid X receptor agonist 5 40 2.30258509299405 NA 4.53660105419896 4.05214209875917 0.484458955439791 1.10418348751123 1.16152847817188 0.418968325261372 0.438748596514276 0.417087453768053 0.382005964500595 NA NA NA 0.3986657531164 99.0475875264609 a4460 loss_cnaBRCA29_(MAP2K4) 263 FR-180204 ERK 7 42 2.99573227355399 NA 5.584056148822 5.32018967946101 0.263866469360988 0.9200384144188 0.700909905936928 0.360206244915503 0.286799404487557 0.376462748102082 0.382093443203475 NA NA NA 0.491566523306392 99.0475875264609 a4461 gain_cnaBRCA27_(CLTC,PPM1D) 1170 CCT018159 HSP90 9 34 2.30258509299405 NA 3.03119014301069 3.42532089276297 -0.394130749752285 1.09518295780824 1.21200211537371 0.331172004436017 0.35987662786595 0.325189820011789 0.382146305845384 NA NA NA 0.364407639885354 99.0475875264609 a4462 TP53_mut 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 38 11 3.68887945411394 NA 3.37848677363156 3.73917952974963 -0.360692756118069 1.14388297100777 1.36445047799005 0.302029853824944 0.315323127680007 0.264350199539231 0.382187893263078 NA NA NA 0.437221338714044 99.0475875264609 a4463 gain_cnaBRCA48 1371 PLX4720 (rescreen) BRAF 5 42 2.30258509299405 NA 4.35062816366355 4.74959010331568 -0.398961939652133 0.330028123505995 0.995793466097218 0.417505226456116 1.20887255126573 0.400647276001691 0.382187930802644 NA NA NA 0.0800152737586133 99.0475875264609 a4464 gain_cnaBRCA15 272 AR-42 HDAC 22 27 1.63315443905142 NA -0.0714383364795558 0.315855770283772 -0.387294106763328 1.74942972343782 1.32403647203908 0.253331293696827 0.221383060762368 0.292510149789814 0.382248709176311 NA NA NA 0.396544203556223 99.0475875264609 a4465 gain_cnaBRCA9_(KRAS) 165 DMOG Prolyl-4-Hydroxylase 4 42 8.29404964010203 NA 6.92346699587268 7.63155329997667 -0.708086304103992 2.38647934466336 1.45181015780029 0.461673096824078 0.296707493273475 0.48772651183048 0.382416000200724 NA NA NA 0.598150698723574 99.0475875264609 a4466 gain_cnaBRCA27_(CLTC,PPM1D) 34 Imatinib ABL, KIT, PDGFR 3 11 0.693147180559945 NA 2.99628050916386 2.71770682265361 0.278573686510254 0.521826227749086 0.461034533982532 0.590560255039394 0.533843781122099 0.60423605169848 0.382418335804082 NA NA NA 0.464394169461841 99.0475875264609 a4467 TP53_mut 157 JNK-9L JNK 37 10 1.63315443905142 NA 0.126367446513726 -0.205091352318518 0.331458798832244 1.10247189219402 0.837826054749301 0.314218352552466 0.300650566403657 0.395617678578192 0.382665058151267 NA NA NA 0.315199773600734 99.0475875264609 a4468 loss_cnaBRCA20 1373 Dabrafenib BRAF 3 43 2.30258509299405 NA 5.01837762483891 4.15851086456031 0.859866760278599 0.274028655954414 1.67108401767868 0.526328262684819 3.13787168456442 0.514556270769107 0.382891362928244 NA NA NA 0.00967830332948962 99.0475875264609 a4469 gain_cnaBRCA19 1494 SN-38 TOP1 4 44 -2.99573227355399 NA -4.01313120851989 -3.2393028100512 -0.773828398468689 2.22136687425025 1.63792852700248 0.460021089469254 0.348356864162687 0.472443324425667 0.382965753731965 NA NA NA 0.541069402985447 99.0475875264609 a4470 loss_cnaBRCA17 305 TPCA-1 IKK 11 38 2.99573227355399 NA 3.85571645737844 4.27171344437122 -0.415996986992782 1.42991209565916 1.36607500452342 0.301467907640331 0.290924867518528 0.304519873078207 0.383066852782871 NA NA NA 0.403726274369998 99.0475875264609 a4471 gain_cnaBRCA12_(TERT) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 9 33 1.38629436111989 0.693147180559945 3.1615873859861 3.50756862732772 -0.34598124134162 1.5612286435661 0.866620233949204 0.331646904061216 0.221608310075161 0.399230513883777 0.383088837020752 NA NA NA 0.538393937914523 99.0475875264609 a4472 loss_cnaBRCA20 155 AP-24534 ABL 3 44 -0.669430653942629 NA 2.0031630588159 1.40732771787522 0.595835340940678 0.255415230682332 1.15857188041559 0.525514848968158 2.33281053502145 0.514284310721359 0.383165210781567 NA NA NA 0.025111705377667 99.0475875264609 a4473 CDH1_mut 1042 BIRB 0796 p38, JNK2 4 39 2.30258509299405 NA 3.97918870269135 4.40632959070276 -0.427140888011405 0.950464501167431 0.920769779370958 0.462787081827289 0.449402252779309 0.463895424872887 0.38320004641157 NA NA NA 0.443995557220333 99.0475875264609 a4474 loss_cnaBRCA29_(MAP2K4) 230 GSK429286A ROCK2 7 42 2.99573227355399 2.32630161961136 5.12941885415405 5.45151770799239 -0.322098853838336 1.05353949601834 0.870948363865283 0.359352430067989 0.305730212351459 0.369825430762458 0.383213505139476 NA NA NA 0.467076065461198 99.0475875264609 a4475 loss_cnaBRCA17 170 Shikonin unknown 10 37 2.77258872223978 NA -0.289320618599217 0.0827779059512053 -0.372098524550422 0.988501513674057 1.23006019929075 0.313823930601096 0.37642686369534 0.302504320329178 0.383257568092072 NA NA NA 0.331308008929185 99.0475875264609 a4476 loss_cnaBRCA28_(GPS2) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 3 40 1.6094379124341 NA 3.56757160057876 2.81548800665108 0.752083593927681 1.32105907943521 1.43111227487432 0.527429708647018 0.56930352747677 0.525523823065335 0.38340439008535 NA NA NA 0.430695067339378 99.0475875264609 a4477 gain_cnaBRCA30_(CRNKL1,FOXA2) 1006 Cytarabine DNA synthesis 5 40 0.693147180559945 NA 1.77555502227607 1.13765555635871 0.637899465917356 1.99401762629741 1.47086834646706 0.417716096577179 0.319906633474368 0.433689029646708 0.383417598589999 NA NA NA 0.5224676331256 99.0475875264609 a4478 gain_cnaBRCA48 1007 Docetaxel Microtubules 5 40 -4.38202663467388 NA -5.15984120054751 -4.51570946239961 -0.644131738147907 1.04885430263135 1.58402173620985 0.417699536472301 0.614128899058636 0.406643244485486 0.383436288881806 NA NA NA 0.267631440165795 99.0475875264609 a4479 MLL3_mut 202 GSK-1904529A IGF1R 3 45 0.0237165266173161 NA 1.78043109754746 2.21695731339299 -0.436526215845532 0.565816479775527 0.842312903428442 0.524542476108053 0.771497882173231 0.518247095668072 0.383602863988853 NA NA NA 0.311758922621736 99.0475875264609 a4480 MLL3_mut 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 3 23 2.30258509299405 NA 2.09896432372068 2.76883542379758 -0.669871100076896 1.29291344523722 1.22371852145539 0.544772977166765 0.518109779540573 0.547406195405301 0.38363386328389 NA NA NA 0.469548055058392 99.0475875264609 a4481 gain_cnaBRCA62 151 QS11 ARFGAP 9 39 2.32630161961136 NA 3.36954514359564 3.85065868102327 -0.481113537427628 1.40614758558411 1.49466471864198 0.325153418057433 0.342150100288211 0.321887264365722 0.383826218879843 NA NA NA 0.377876560222085 99.0475875264609 a4482 NF1_mut 272 AR-42 HDAC 5 44 1.63315443905142 NA -0.427539149613759 0.206685412345009 -0.634224561958768 0.635460448076242 1.58662716131114 0.414826603690189 0.99805513290211 0.399731315222579 0.38388299998816 NA NA NA 0.115391655609499 99.0475875264609 a4483 gain_cnaBRCA15 192 LFM-A13 BTK 22 26 2.77258872223978 NA 4.91073190937912 4.69794092147061 0.212790987908503 0.929399204123604 0.748872918283167 0.254493155787149 0.228955422991951 0.284148328392403 0.384225554037801 NA NA NA 0.393390423742874 99.0475875264609 a4484 MLL3_mut 1161 ZG-10 IRAK1 3 23 2.30258509299405 NA 1.30177140502727 2.06327657838101 -0.761505173353737 0.926582059399765 1.43490712559333 0.544081523688411 0.821843209274995 0.530699973379012 0.384228218726754 NA NA NA 0.292551324345566 99.0475875264609 a4485 gain_cnaBRCA13_(FGFR1,WHSC1L1) 56 WH-4-023 SRC family, ABL 3 9 1.63315443905142 NA 2.71500584378107 3.39271046311343 -0.677704619332362 1.70187267880751 0.91425034940939 0.606653378447857 0.39821111636108 0.741268099892073 0.384241897939678 NA NA NA 0.567710718328789 99.0475875264609 a4486 loss_cnaBRCA18 186 Bexarotene Retinioic acid X family agonist 16 31 2.07944154167984 NA 3.8076492634231 3.49950543580628 0.308143827616822 0.845143543928346 1.26081767770282 0.270482386078396 0.364605314482467 0.244399989836955 0.384242485691236 NA NA NA 0.325501195141824 99.0475875264609 a4487 TP53_mut 186 Bexarotene Retinioic acid X family agonist 37 10 2.07944154167984 NA 3.68031316076372 3.32354697765066 0.356766183113058 1.2203662839902 0.729483568799952 0.313161980211916 0.292343526524306 0.489066784190852 0.384253270076751 NA NA NA 0.254554250479732 99.0475875264609 a4488 gain_cnaBRCA12_(TERT) 277 ABT-869 VEGFR and PDGFR family 9 39 0.0237165266173161 NA 2.56572417740325 2.72000611035274 -0.154281932949484 0.419284020325213 0.486008229663772 0.324750963788419 0.367965210860688 0.317447161452839 0.384410248543487 NA NA NA 0.351829530677293 99.0475875264609 a4489 ARID1A_mut 133 Doxorubicin DNA intercalating 5 43 0.0237165266173161 NA -1.7122243863812 -0.951391564598216 -0.760832821782981 1.69785428341165 1.84616873329338 0.414905856876153 0.4481143224224 0.412114455229522 0.384448475816045 NA NA NA 0.389287416926878 99.0475875264609 a4490 gain_cnaBRCA47_(EGFR) 155 AP-24534 ABL 7 40 -0.669430653942629 NA 1.09812260607342 1.50612626301108 -0.408003656937661 1.2423180307988 1.11624515255676 0.359834396527256 0.328421263173102 0.365514381857004 0.384457560303219 NA NA NA 0.440156679849692 99.0475875264609 a4491 gain_cnaBRCA19 204 Tipifarnib Farnesyl-transferase (FNTA) 4 44 2.77258872223978 NA 0.984172057703475 1.67777693384658 -0.693604876143107 1.38974015793874 1.52114410912911 0.458453757791825 0.499089611954412 0.455975782952092 0.384575409850822 NA NA NA 0.401090016982313 99.0475875264609 a4492 POLR2B_mut 1069 EHT 1864 Rac GTPases 3 43 2.30258509299405 NA 3.14098476234421 3.59075450183374 -0.449769739489533 0.699398156374384 0.864924641535775 0.524149921428738 0.643081105362214 0.520010319848114 0.384846570703698 NA NA NA 0.382837130914818 99.0475875264609 a4493 loss_cnaBRCA29_(MAP2K4) 1375 Temozolomide DNA akylating agent 7 39 3.40119738166216 NA 5.68714665204987 5.93835298627722 -0.251206334227357 0.634713596874755 0.706917668451616 0.360146296896714 0.395779033983616 0.35535444286968 0.385052826139898 NA NA NA 0.368639505418778 99.0475875264609 a4494 CDH1_mut 344 THZ-2-49 CDK9 4 45 2.99573227355399 NA 1.16663450450079 1.84026526123077 -0.673630756729981 0.89905686797498 1.5039549915651 0.457385310595728 0.749263790451048 0.447906194339608 0.385141956043509 NA NA NA 0.241583898346301 99.0475875264609 a4495 loss_cnaBRCA38 1032 Afatinib ERBB2, EGFR 3 42 -0.693147180559945 NA 1.18619459672446 0.226491491371617 0.959703105352844 0.755854600813577 1.86703034363863 0.524322661486651 1.26969274820825 0.514026517363662 0.385167090088402 NA NA NA 0.138863515931117 99.0475875264609 a4496 gain_cnaBRCA16 1053 MK-2206 AKT1, AKT2 14 28 1.38629436111989 0.693147180559945 1.70872353245106 1.23645681304175 0.472266719409304 1.39803098019572 1.74925507663908 0.287378450942703 0.337808479282188 0.269981620014327 0.38521099934699 NA NA NA 0.350936999120448 99.0475875264609 a4497 MLL3_mut 1043 JNK Inhibitor VIII JNK 3 40 2.30258509299405 NA 5.16133644628417 4.77003078629338 0.391305659990789 0.853120187637003 0.739416394308032 0.524984973788567 0.458675888416893 0.529208796292628 0.385592613706367 NA NA NA 0.513013911450941 99.0475875264609 a4498 TP53_mut 205 BMS-708163 g-secretase 37 11 2.32630161961136 0.940007258491471 4.94330659428784 4.73918844155379 0.204118152734052 0.711324879962185 0.544378076523088 0.300821722939738 0.286954890070629 0.374956600085263 0.385601534881893 NA NA NA 0.322559691565133 99.0475875264609 a4499 loss_cnaBRCA38 223 ZSTK474 PI3K 4 45 1.63315443905142 2.32630161961136 0.305274988411283 0.966299114481087 -0.661024126069804 0.813944679185917 1.47999394627407 0.456927631757281 0.812124144273466 0.446639749935432 0.385613854127202 NA NA NA 0.212754201153978 99.0475875264609 a4500 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 6 37 1.6094379124341 NA 3.44540316534576 2.86490715397747 0.58049601136829 1.37362797845374 1.52136080699841 0.385936870102282 0.422600602545778 0.381563668984997 0.385641106992722 NA NA NA 0.375313878221324 99.0475875264609 a4501 loss_cnaBRCA7_(FAS,PTEN) 260 NG-25 MAP3K7 (TAK1) 4 45 2.32630161961136 NA 2.66949334531172 3.25624118772987 -0.586747842418152 0.60805589645569 1.31786265728627 0.45685114340853 0.964957080160325 0.44522685211096 0.385692754372578 NA NA NA 0.156507628426071 99.0475875264609 a4502 MACF1_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 3 40 2.30258509299405 NA 3.25075195701469 3.85083304582135 -0.600081088806657 0.897955750714658 1.1551983944684 0.524549715635171 0.66827467648497 0.519461498284719 0.385983031004489 NA NA NA 0.368056845080242 99.0475875264609 a4503 BRCA2_mut 1054 PD-0332991 CDK4, CDK6 5 37 1.38629436111989 0.693147180559945 2.34418760953604 2.95570435031298 -0.611516740776933 1.6870409003888 1.43746140674338 0.417607183996513 0.362478906490056 0.425414371410739 0.386016612606632 NA NA NA 0.475457300523981 99.0475875264609 a4504 loss_cnaBRCA38 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 39 -1.38629436111989 0.693147180559945 0.523959983062848 -0.365791565111283 0.88975154817413 1.29571586803051 1.71283722847907 0.5251063332517 0.686687236088689 0.51946065474312 0.386031389030683 NA NA NA 0.357519710291834 99.0475875264609 a4505 CDH1_mut 1004 Vinblastine Microtubules 4 41 -2.30258509299405 NA -2.91970128259374 -3.50783928960701 0.588138007013277 0.975243090248147 1.30245422189394 0.458645154608375 0.603068109781354 0.451561365556516 0.38612695006695 NA NA NA 0.326254393536941 99.0475875264609 a4506 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1219 PFI-1 BRD2, BRD3, BRD4 6 41 2.30258509299405 NA 3.50523654245762 3.12378513853152 0.381451403926105 1.34380145878315 0.944992344823545 0.382517849661629 0.28385994183361 0.403655549185779 0.3861527828874 NA NA NA 0.527992622247366 99.0475875264609 a4507 BRCA2_mut 1059 AZD8055 MTORC1/2 5 38 0.693147180559945 NA -0.240369120903287 0.179220188195668 -0.419589309098955 1.00948262288993 1.00663171757082 0.416709757163368 0.415647877026118 0.416825043136428 0.386163800055752 NA NA NA 0.421319171707547 99.0475875264609 a4508 gain_cnaBRCA19 194 AUY922 HSP90 3 44 -1.36257783450257 NA -3.23765308200536 -2.33620802886796 -0.901445053137399 0.489456709500273 1.76286790924197 0.522172897035169 1.84172580667606 0.511351445228258 0.386172269117012 NA NA NA 0.053871691304954 99.0475875264609 a4509 gain_cnaBRCA31 6 PHA-665752 MET 4 10 0.693147180559945 NA 3.15237685889308 2.74919931568504 0.403177543208046 0.729631717682648 0.767102564912212 0.531960674380077 0.552576777348113 0.525584923906734 0.386245895712666 NA NA NA 0.393748427586899 99.0475875264609 a4510 gain_cnaBRCA14_(RAD21) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 21 28 3.68887945411394 NA 3.28716587157078 3.58867817579496 -0.301512304224177 0.985298957654442 1.32822920255722 0.252438877227895 0.306010984667987 0.227003218754474 0.386306945108022 NA NA NA 0.366284123839862 99.0475875264609 a4511 loss_cnaBRCA57 166 FTI-277 Farnesyl transferase (FNTA) 5 42 0.0237165266173161 NA 2.54550781313869 2.20854030934182 0.336967503796874 0.316644540520015 0.847534355857911 0.413721349604252 1.06418226331483 0.397585657109771 0.386479941081706 NA NA NA 0.104323220483903 99.0475875264609 a4512 gain_cnaBRCA16 177 GSK-650394 SGK3 16 31 2.77258872223978 NA 4.31531521666182 3.85914776327059 0.456167453391235 2.0352763770707 1.49567700854154 0.269166342621073 0.224130471188281 0.304990616815092 0.386540652350201 NA NA NA 0.435781275263821 99.0475875264609 a4513 PIK3CA_mut 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 16 30 1.63315443905142 NA 2.21747067130744 1.78679460183062 0.430676069476817 1.95307959611571 1.36664899450322 0.270688411830356 0.22051127375113 0.315132906261252 0.386647026860208 NA NA NA 0.440200981711737 99.0475875264609 a4514 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 175 PAC-1 CASP3 agonist 15 33 0.940007258491471 NA 2.1727750816989 2.50529394547411 -0.332518863775219 1.28841768475173 1.19151586445637 0.272150105154053 0.258083126078243 0.2790721245889 0.386681178707368 NA NA NA 0.404276585491861 99.0475875264609 a4515 gain_cnaBRCA13_(FGFR1,WHSC1L1) 310 YM201636 FYV1 11 38 1.63315443905142 NA 2.65043998640698 2.3464175488341 0.304022437572886 0.944337048117016 1.0349365014351 0.299135571791216 0.321942719687953 0.293759508096692 0.386728585618628 NA NA NA 0.370134397459773 99.0475875264609 a4516 MACF1_mut 1039 SL 0101-1 RSK, AURKB, PIM3 3 40 2.30258509299405 NA 5.11815458502774 4.61362889221543 0.504525692812317 0.534481310950171 0.980494516130813 0.523616977921217 0.943953852970835 0.514562483024643 0.386820519467208 NA NA NA 0.236618644034208 99.0475875264609 a4517 PIK3CA_mut 197 Bryostatin 1 PRKC 17 31 -4.8283137373023 NA -2.97124471370652 -2.71662671533343 -0.254617998373086 1.19071851043047 0.820976143376674 0.263641601454423 0.21383559266332 0.310140556978723 0.386889230023859 NA NA NA 0.439831454259028 99.0475875264609 a4518 MLL3_mut 194 AUY922 HSP90 3 44 -1.36257783450257 NA -3.23636753997581 -2.33629567946088 -0.900071860514933 0.812510894702209 1.75735647152041 0.521363953858073 1.10776589752045 0.512173753647272 0.386902381910494 NA NA NA 0.181063914491246 99.0475875264609 a4519 loss_cnaBRCA42 163 JQ1 BRD4 3 44 0.940007258491471 NA -0.395039911888629 0.364391062071092 -0.75943097395972 0.892143370791939 1.47828310162121 0.521140756816371 0.851243195682313 0.513724991597932 0.387103981826562 NA NA NA 0.27442988438112 99.0475875264609 a4520 gain_cnaBRCA13_(FGFR1,WHSC1L1) 346 THZ-2-102-1 CDK7 11 37 0.916290731874155 2.99573227355399 -1.92282981294649 -1.16044428957219 -0.762385523374308 2.74740039367027 2.48310600324132 0.299809586739377 0.277493417097401 0.307028988041239 0.387189061422052 NA NA NA 0.421833692815275 99.0475875264609 a4521 gain_cnaBRCA30_(CRNKL1,FOXA2) 329 QL-XI-92 DDR1 5 43 2.32630161961136 NA 4.60282961077878 4.21269620138032 0.390133409398462 1.1546300993374 0.923723062389213 0.412384914051648 0.337886055129124 0.422348889275733 0.387319941606637 NA NA NA 0.501345473915397 99.0475875264609 a4522 gain_cnaBRCA15 111 Salubrinal GADD34-PP1C 6 7 2.77258872223978 NA 2.93819713371005 3.49298365655243 -0.554786522842377 1.23801780579088 0.986839522144358 0.500668152850076 0.448124833299925 0.562185148033847 0.387440787182685 NA NA NA 0.398777018268773 99.0475875264609 a4523 CDH1_mut 204 Tipifarnib Farnesyl-transferase (FNTA) 4 44 2.77258872223978 NA 2.25195036887666 1.56252436010357 0.689426008773095 1.64939666041812 1.50310230222462 0.455645790582905 0.417986785906506 0.458668719855416 0.387469872985124 NA NA NA 0.471793899243663 99.0475875264609 a4524 loss_cnaBRCA18 1005 Cisplatin DNA crosslinker 14 31 1.79175946922805 2.30258509299405 3.89894994234992 3.56672453640251 0.332225405947413 1.0261770635561 1.24321642668609 0.281115506435171 0.323750566784374 0.267230547164656 0.387502320143581 NA NA NA 0.354982300581464 99.0475875264609 a4525 gain_cnaBRCA14_(RAD21) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 19 24 -1.38629436111989 0.693147180559945 -2.07803791451144 -2.33330246177143 0.255264547259992 1.07053821643481 0.847215603035224 0.268209811388615 0.238445058141029 0.301298213046932 0.387521572529454 NA NA NA 0.40141091223053 99.0475875264609 a4526 loss_cnaBRCA18 38 AZD-0530 SRC, ABL1 6 8 0.693147180559945 NA 2.76685502001532 2.45120120743973 0.315653812575586 0.691265225005517 0.622623327948684 0.484055295198642 0.456631986041344 0.506973957457632 0.387721647493644 NA NA NA 0.398058076469891 99.0475875264609 a4527 loss_cnaBRCA60 274 PXD101, Belinostat HDAC 3 45 2.99573227355399 NA -0.0570797355253993 0.720075551398618 -0.777155286924018 0.145235027721433 1.528052727115 0.519915656468941 5.35101827098238 0.508591930849994 0.387777625508014 NA NA NA 0.00266232205832441 99.0475875264609 a4528 gain_cnaBRCA47_(EGFR) 173 FH535 unknown 7 41 3.46573590279973 NA 1.18335335951619 1.63952277689892 -0.456169417382723 0.901852340853739 1.32672255838288 0.356568491454101 0.505813864108718 0.343831809069969 0.387794824280727 NA NA NA 0.277023247883164 99.0475875264609 a4529 gain_cnaBRCA15 45 Z-LLNle-CHO g-secretase 6 6 0.940007258491471 NA 0.578980325178598 1.37073097723928 -0.791750652060686 1.62366269876477 1.40615850682734 0.521297008257972 0.487632469886156 0.563059319569231 0.387804215287683 NA NA NA 0.388226422306812 99.0475875264609 a4530 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1161 ZG-10 IRAK1 9 17 2.30258509299405 NA 2.30730049688034 1.79970417917188 0.507596317708459 1.77183560911106 1.17051611714481 0.362580595167003 0.286480481088832 0.433651711645474 0.387821966648146 NA NA NA 0.453805641682009 99.0475875264609 a4531 gain_cnaBRCA12_(TERT) 1091 BMS-536924 IGF1R 10 37 1.38629436111989 NA 2.75576123948741 3.09561059208828 -0.339849352600865 1.05355848879473 1.1035840773814 0.310715994172242 0.322572838827063 0.307950576278036 0.387946680123932 NA NA NA 0.384670288147332 99.0475875264609 a4532 loss_cnaBRCA23 200 LAQ824 HDAC 3 45 0.0237165266173161 NA -3.3712417507445 -2.63868245382769 -0.732559296916817 0.398433614918346 1.43906358465378 0.51958913786103 1.83859812397342 0.509052765095894 0.3880733186779 NA NA NA 0.0539755106952432 99.0475875264609 a4533 MLL3_mut 224 AS605240 PI3Kgamma 3 46 2.99573227355399 2.32630161961136 2.50053257601092 3.32045615193123 -0.819923575920306 1.05745082763275 1.59897904503329 0.519030474764033 0.775377496990394 0.512779437896409 0.388163902959233 NA NA NA 0.309824998339598 99.0475875264609 a4534 loss_cnaBRCA36_(FAT1,IRF2) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 9 38 2.32630161961136 NA 1.81691505851909 1.32220445918348 0.494710599335616 1.57218993879658 1.52282177911004 0.322978306179304 0.314663379485999 0.324864410347961 0.388247964065298 NA NA NA 0.41013826701611 99.0475875264609 a4535 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 272 AR-42 HDAC 6 43 1.63315443905142 NA -0.367305595026463 0.213030138727218 -0.580335733753681 0.922008832149861 1.58598778463013 0.37952315274728 0.629425352033238 0.365914378015857 0.388255240430283 NA NA NA 0.224357418684019 99.0475875264609 a4536 loss_cnaBRCA38 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 4 41 -0.669430653942629 NA -4.49577163609352 -3.38769586623695 -1.10807576985657 1.60585468303916 2.48021536218511 0.456102153844206 0.690022441980542 0.446765948937731 0.388743096666236 NA NA NA 0.274207460335707 99.0475875264609 a4537 gain_cnaBRCA9_(KRAS) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 4 39 1.6094379124341 NA 3.45957499981813 2.80728038637197 0.652294613446158 0.537138261439087 1.47376105662613 0.457352921543096 1.21438865981832 0.442605407785337 0.388759321172184 NA NA NA 0.10138640692573 99.0475875264609 a4538 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 290 KIN001-260 IKK 15 34 2.99573227355399 NA 5.23889189104829 4.95812440440715 0.280767486641146 0.601011426177991 1.17944584159783 0.269629869238388 0.46715831748263 0.238050342575105 0.388791691043914 NA NA NA 0.276515324536493 99.0475875264609 a4539 loss_cnaBRCA36_(FAT1,IRF2) 330 XMD13-2 RIPK 9 39 2.32630161961136 NA 4.03885243193515 3.64767558564691 0.391176846288244 1.00697228234742 1.25537352720554 0.321737958642604 0.388468335371004 0.311601955761327 0.388800449753348 NA NA NA 0.333928794585216 99.0475875264609 a4540 gain_cnaBRCA16 1371 PLX4720 (rescreen) BRAF 16 31 2.30258509299405 NA 4.87599088942428 4.6200022879609 0.255988601463377 0.881260369203367 0.990989437120681 0.267822671979113 0.290480101465113 0.258316175606424 0.388895989471361 NA NA NA 0.372489666598385 99.0475875264609 a4541 gain_cnaBRCA62 110 Roscovitine CDKs 5 8 2.77258872223978 NA 3.75913912038204 4.28057699543506 -0.521437875053029 0.772693710537486 1.13700326166812 0.51136426771749 0.674831266182194 0.458607193692671 0.38893285121789 NA NA NA 0.346761045850082 99.0475875264609 a4542 NF1_mut 304 SB52334 ALK5 5 44 2.99573227355399 NA 4.77061877725791 4.24862731265739 0.521991464600519 1.45562091827873 1.2542669724227 0.410162873484809 0.358603986824931 0.416172534298863 0.389209231628328 NA NA NA 0.478169936920179 99.0475875264609 a4543 gain_cnaBRCA27_(CLTC,PPM1D) 1025 SB 216763 GSK3A, GSK3B 10 29 2.30258509299405 NA 4.70242467620068 4.95355328394912 -0.251128607748439 0.803796785700117 0.780353818403849 0.319453067674988 0.312427982067262 0.321813774503086 0.389310515032521 NA NA NA 0.4039864664461 99.0475875264609 a4544 loss_cnaBRCA36_(FAT1,IRF2) 298 OSI-930 KIT, VEGFR, PDGFR 9 39 2.32630161961136 NA 3.68536085076407 3.9659841685218 -0.280623317757734 0.719193790230761 0.902469523197599 0.321313632046759 0.390191519406325 0.310950464857184 0.389421252575611 NA NA NA 0.332566848370627 99.0475875264609 a4545 gain_cnaBRCA14_(RAD21) 300 CX-5461 RNA Pol I 21 28 2.32630161961136 NA 3.66775260409775 4.09582481006821 -0.428072205970462 1.74178864748326 1.68082730121189 0.250769523098031 0.245765872104512 0.254679469843106 0.3894305000176 NA NA NA 0.39234921234158 99.0475875264609 a4546 loss_cnaBRCA36_(FAT1,IRF2) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 9 37 2.30258509299405 NA 1.1547563635293 1.47603348192859 -0.321277118399294 0.787387290625406 1.03496475715865 0.32303917009105 0.408029342388941 0.310423245020743 0.389477691015477 NA NA NA 0.32009082312014 99.0475875264609 a4547 loss_cnaBRCA60 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 3 40 1.6094379124341 NA 3.67444690533429 2.89126607433095 0.783180831003339 0.850591731186779 1.53036486426333 0.520611246032489 0.9207482300711 0.511760854742531 0.389527125145093 NA NA NA 0.24569255382342 99.0475875264609 a4548 loss_cnaBRCA17 59 WZ-1-84 BMX 3 9 2.32630161961136 NA 4.10171802664258 3.38195669880146 0.719761327841127 0.316140202433943 1.33258651286666 0.599672362174097 2.27671559105654 0.540123527359417 0.389528516091399 NA NA NA 0.165401852612508 99.0475875264609 a4549 gain_cnaBRCA31 221 TAK-715 p38a 16 33 2.99573227355399 2.32630161961136 4.66137006755824 4.39525945151374 0.266110616044497 1.05239750053312 0.983610323073153 0.264503812752891 0.252861315149164 0.270544757209411 0.389662843005085 NA NA NA 0.403766657979657 99.0475875264609 a4550 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 157 JNK-9L JNK 5 42 1.63315443905142 NA 0.443248937874129 0.00972469782028662 0.433524240053843 1.40269849408717 1.01487067195464 0.410871817929028 0.309064451042964 0.427171906760176 0.389732125543806 NA NA NA 0.535301089613701 99.0475875264609 a4551 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1061 SB590885 BRAF 14 28 1.6094379124341 NA 3.80565525841109 4.11503991541666 -0.309384657005573 0.817650694806306 1.19546799134546 0.284576426508049 0.378382430261205 0.258797942935613 0.389818045469304 NA NA NA 0.331551150713816 99.0475875264609 a4552 gain_cnaBRCA15 32 VX-680 AURKA, AURKB, AURKC, FLT3, ABL1, JAK2 6 6 0.693147180559945 NA 0.633251005219073 1.74903147818048 -1.11578047296141 2.6088363705411 1.56177422802564 0.518963004175137 0.427692777347313 0.71443135181706 0.389852388728115 NA NA NA 0.394423253479699 99.0475875264609 a4553 PTEN_mut 170 Shikonin unknown 8 39 2.77258872223978 NA -0.328029528623475 0.0716362195689803 -0.399665748192456 1.00336497119912 1.21662161102761 0.336994926419842 0.398325394711373 0.328504560966068 0.389856990212512 NA NA NA 0.343431717826735 99.0475875264609 a4554 gain_cnaBRCA31 133 Doxorubicin DNA intercalating 16 32 0.0237165266173161 NA -0.705689288287776 -1.19312283115703 0.48743354286925 1.67165690934355 1.90773512901131 0.265762429562227 0.291587071572398 0.255503783233191 0.389913013915531 NA NA NA 0.370452683348941 99.0475875264609 a4555 gain_cnaBRCA62 53 CGP-60474 CDK1,CDK2,CDK5,CDK7,CDK9 4 8 -1.36257783450257 NA -2.25040405511682 -1.4251237979873 -0.82528025712952 0.678620107471432 1.73689536878571 0.550196443309471 1.21611524333482 0.475146788897528 0.390057115456609 NA NA NA 0.267269826027038 99.0475875264609 a4556 loss_cnaBRCA7_(FAS,PTEN) 1243 piperlongumine Increases ROS levels 4 43 2.30258509299405 NA 2.06422229974857 1.67731925388126 0.386903045867315 0.672501363873491 0.864524077985508 0.453542838562056 0.575319347515997 0.44753299036953 0.390201336431394 NA NA NA 0.344582991679492 99.0475875264609 a4557 NF1_mut 224 AS605240 PI3Kgamma 5 44 2.99573227355399 2.32630161961136 2.68971218946232 3.3362277220354 -0.646515532573077 0.804320364599589 1.6333614826133 0.40923008191764 0.803803510427003 0.395819014624174 0.39028007506208 NA NA NA 0.174328232214896 99.0475875264609 a4558 BRCA2_mut 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 6 42 2.32630161961136 NA 4.72817951651379 4.99139195875766 -0.263212442243869 0.332780348005775 0.727437202162081 0.378464768047716 0.790949477098634 0.361835277961523 0.390349116519712 NA NA NA 0.158460930066337 99.0475875264609 a4559 gain_cnaBRCA9_(KRAS) 1129 PF-4708671 RPS6KB1 (p70S6KA) 3 40 2.30258509299405 NA 4.36210691968147 3.76748142362134 0.59462549606013 0.613672408186794 1.16489793328919 0.519692733182095 0.96896241077069 0.510452872365526 0.390356606331895 NA NA NA 0.227304192670362 99.0475875264609 a4560 ARID1A_mut 328 SNX-2112 HSP90 5 43 0.940007258491471 NA -0.330989022580265 0.504243326450051 -0.835232349030316 1.59896648271185 2.075786628104 0.409677484355354 0.522357634172395 0.402369076725967 0.390418826037465 NA NA NA 0.328624355368801 99.0475875264609 a4561 NF1_mut 261 TL-1-85 MAP3K7 (TAK1) 5 44 2.32630161961136 NA 4.46974265110999 3.97424553581006 0.495497115299932 0.991856187114016 1.22971803021433 0.409064187633967 0.499565483118747 0.402935553619207 0.390470714887307 NA NA NA 0.345843440397502 99.0475875264609 a4562 BRCA1_mut 1033 Vismodegib SMO 4 41 2.30258509299405 NA 5.08342723663172 4.72819869973555 0.355228536896166 0.484000893323547 0.799811242343194 0.454298256485602 0.73394190340616 0.444140464761984 0.390605637288229 NA NA NA 0.251304114129004 99.0475875264609 a4563 loss_cnaBRCA28_(GPS2) 298 OSI-930 KIT, VEGFR, PDGFR 4 44 2.32630161961136 NA 4.27570695632759 3.88042732736174 0.395279628965854 0.628431819425664 0.887971800852563 0.452576034161923 0.628993658098198 0.445148853360363 0.39064984163303 NA NA NA 0.308984977766901 99.0475875264609 a4564 CDH1_mut 1373 Dabrafenib BRAF 5 41 2.30258509299405 NA 4.81274956600331 4.14164273708765 0.671106828915661 0.43700861922558 1.7083507974846 0.410671552715517 1.53568327806652 0.392839005843417 0.390674338005865 NA NA NA 0.0535052432574953 99.0475875264609 a4565 gain_cnaBRCA8_(CHD4,WNK1) 163 JQ1 BRD4 3 44 0.940007258491471 NA -0.389673790339352 0.364025190147277 -0.75369898048663 1.52413987640156 1.45425593303783 0.517141410953562 0.49450774968639 0.518271208914519 0.390727557412653 NA NA NA 0.48463562917633 99.0475875264609 a4566 gain_cnaBRCA9_(KRAS) 306 TG101348 JAK2 4 44 2.32630161961136 NA 3.7568155242793 3.17653196869147 0.580283555587833 1.27805308965703 1.28276354591292 0.452478028174096 0.454037129039414 0.452369852134248 0.390751635367807 NA NA NA 0.439244297474066 99.0475875264609 a4567 gain_cnaBRCA9_(KRAS) 1375 Temozolomide DNA akylating agent 4 42 3.40119738166216 NA 6.18902398382282 5.87261183556832 0.316412148254503 0.227179430250546 0.720112522463849 0.453535798648536 1.39278520025139 0.439392648209901 0.390788295596326 NA NA NA 0.0724318202049054 99.0475875264609 a4568 gain_cnaBRCA15 1013 Nilotinib ABL 19 21 0.693147180559945 NA 3.34098103283336 3.07798360344708 0.262997429386282 0.894383794723423 1.01009873372412 0.274805252896347 0.294054332086384 0.260368041861254 0.390884475902532 NA NA NA 0.387969809286222 99.0475875264609 a4569 loss_cnaBRCA33 295 NVP-BHG712 EPHB4 6 43 2.32630161961136 NA 3.47991570890805 3.94347000254937 -0.463554293641318 2.04164039552248 1.0918786690942 0.377384488505938 0.227049922531871 0.424547439896296 0.390913328523536 NA NA NA 0.607237058375504 99.0475875264609 a4570 loss_cnaBRCA38 279 BIX02189 MAP2K5 (MEK5) 4 45 2.99573227355399 NA 4.65432935304915 5.06051397267823 -0.406184619629078 0.895723606746306 0.899807526446674 0.451543317800917 0.453470932963946 0.451412782946032 0.391192791365528 NA NA NA 0.439577622174702 99.0475875264609 a4571 PIK3CA_mut 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 17 31 2.07944154167984 NA 3.01851866164101 3.32166930294463 -0.303150641303615 1.50888664161477 0.922309114266533 0.261231597514833 0.200910149869967 0.328686593913469 0.39120916136411 NA NA NA 0.45820395320424 99.0475875264609 a4572 NF1_mut 1378 Bleomycin (50 uM) DNA damage 5 43 3.91202300542815 NA 4.5032570710985 3.73242232736508 0.770834743733418 1.121688175768 1.94214361995258 0.408924512894904 0.687209476203708 0.396898939817973 0.391283424785231 NA NA NA 0.226278240073375 99.0475875264609 a4573 ASH1L_mut 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 3 42 -0.669430653942629 NA -4.65975782236879 -3.40236532364244 -1.25739249872635 0.971650249983811 2.47895873973851 0.517514569264654 1.29407932406471 0.507226069788876 0.391314167223093 NA NA NA 0.13351302508216 99.0475875264609 a4574 gain_cnaBRCA31 177 GSK-650394 SGK3 16 31 2.77258872223978 NA 4.31231356518062 3.86069700274475 0.451616562435867 2.0353330070957 1.49612422897183 0.266436108719523 0.221888290938837 0.301857662412316 0.391335959106492 NA NA NA 0.440352734383186 99.0475875264609 a4575 loss_cnaBRCA28_(GPS2) 190 Bleomycin DNA damage 4 44 4.15888308335967 NA 0.942490016272061 2.18166362360736 -1.2391736073353 2.36038154620834 2.76678836080124 0.451903458372143 0.524988686395162 0.447874374813563 0.391348745948319 NA NA NA 0.381075008016739 99.0475875264609 a4576 loss_cnaBRCA20 1377 Afatinib (rescreen) ERBB2, EGFR 3 44 2.30258509299405 NA 3.79517233308884 2.7691492979741 1.02602303511474 0.770753130235784 2.02593649260627 0.516352624060723 1.3311954176571 0.506443829241069 0.391444738458897 NA NA NA 0.125348580562942 99.0481506403121 a4577 gain_cnaBRCA64_(SDHC) 1021 Axitinib PDGFR, KIT, VEGFR 9 36 0.693147180559945 NA 2.76417569103592 2.38689590301961 0.377279788016308 1.49357266222565 1.08220362264901 0.322532218597708 0.252602231922286 0.348621812125157 0.391597708904449 NA NA NA 0.492141387429466 99.0481506403121 a4578 gain_cnaBRCA31 1 Erlotinib EGFR 4 8 0.693147180559945 NA 3.13410210766407 2.82280783801286 0.31129426965121 0.356024430618567 0.637324747024093 0.54828276365099 0.874362102371341 0.488439011829932 0.391646182605169 NA NA NA 0.304625976169273 99.0481506403121 a4579 TP53_mut 1230 IOX2 EGLN1 37 10 -2.30258509299405 NA 0.292314606861005 0.0909107024679056 0.2014039043931 0.671228134801963 0.577055571498253 0.308201991784537 0.300052834424948 0.34901994598229 0.391766012179351 NA NA NA 0.358781523864263 99.0481506403121 a4580 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 6 40 2.30258509299405 NA 1.74065965668803 1.36405220407483 0.376607452613198 0.731038774966627 1.02352372490917 0.378641573606874 0.515167547207589 0.367951854410231 0.391796590894969 NA NA NA 0.298472962088253 99.0481506403121 a4581 gain_cnaBRCA16 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 16 30 0 NA 1.01261150506061 0.461537086947212 0.551074418113401 2.10716912145914 2.03293199215851 0.267701466929497 0.261523582754383 0.271073710403999 0.391864218052742 NA NA NA 0.399290782500038 99.0481506403121 a4582 gain_cnaBRCA62 294 MPS-1-IN-1 MPS1 10 39 2.99573227355399 NA 4.47093181030403 4.82974485491577 -0.358813044611741 1.34225974929759 1.12767668888908 0.306203374203486 0.267320125482052 0.318187870820688 0.392051179698652 NA NA NA 0.451165412624972 99.0702035498394 a4583 loss_cnaBRCA29_(MAP2K4) 221 TAK-715 p38a 7 42 2.99573227355399 2.32630161961136 4.17806498918876 4.53283400134676 -0.354769012157999 1.04815137456977 0.999865066044507 0.352597605376711 0.338471160526428 0.354816889004308 0.392147718283975 NA NA NA 0.428435792850674 99.0702035498394 a4584 gain_cnaBRCA15 228 KIN001-102 AKT1 22 27 2.32630161961136 NA 1.75153490968685 2.10028548851536 -0.348750578828515 1.55667002342283 1.27150168141485 0.248029839130629 0.224036291301914 0.274282436213885 0.39220814670737 NA NA NA 0.402656259508859 99.0702035498394 a4585 PTEN_mut 176 IPA-3 PAK1, PAK2, PAK3 8 39 3.46573590279973 NA 4.91650423894222 4.41075436509319 0.505749873849031 1.59804256582202 1.49164631451187 0.335224574577966 0.316480852679213 0.339054820790097 0.392331697806119 NA NA NA 0.429530229808979 99.0782514081732 a4586 gain_cnaBRCA61_(NOTCH2) 269 NSC-207895 MDM4 3 46 2.99573227355399 NA 4.03058774226512 4.64133509453172 -0.610747352266592 0.806692413392144 1.2015086638832 0.514363232403636 0.757100652153647 0.508317060563423 0.392411141685709 NA NA NA 0.319068444791699 99.0782514081732 a4587 loss_cnaBRCA38 271 VNLG/124 HDAC, RAR 4 45 1.63315443905142 NA 3.81556906504841 4.181295309238 -0.365726244189586 0.912981147551148 0.805549201466989 0.449941356836472 0.400584661764987 0.454008573931376 0.392862374804168 NA NA NA 0.488389719756398 99.170556744222 a4588 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 256 JW-7-24-1 LCK 6 42 2.32630161961136 NA 2.22062081861327 1.78284745864345 0.437773359969822 0.556890133127023 1.21673227184179 0.376325428798677 0.786103638632736 0.359794319671621 0.3930121289418 NA NA NA 0.160779227543179 99.1713141737749 a4589 gain_cnaBRCA15 1042 BIRB 0796 p38, JNK2 20 23 2.30258509299405 NA 4.23627167659335 4.47992066592635 -0.243648989333003 1.05453426854719 0.792729159620867 0.263880846953377 0.231048906232961 0.307354644869544 0.393112642641718 NA NA NA 0.40324893918789 99.1713141737749 a4590 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 154 CHIR-99021 GSK3B 5 42 0.940007258491471 NA 2.94533918240292 3.31473420173879 -0.369395019335877 1.11032988502656 0.883047925308438 0.407917231811614 0.332689432498741 0.418318200800768 0.393122318039232 NA NA NA 0.507727283539016 99.1713141737749 a4591 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1031 Elesclomol HSP70 6 38 -1.6094379124341 NA -2.39364056615986 -3.06977988705667 0.676139320896815 2.11518544631162 1.734826725985 0.378924516582145 0.319659593949949 0.389744584153162 0.393273224937991 NA NA NA 0.484237576266898 99.1796542891263 a4592 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1036 PLX4720 BRAF 8 35 2.30258509299405 NA 4.26594693983451 4.67219710540926 -0.406250165574752 1.0040946601685 1.23843678042387 0.338072256623151 0.404593492715693 0.328034641732547 0.393326688397675 NA NA NA 0.343093698694291 99.1796542891263 a4593 PTEN_mut 301 PHA-793887 CDK-pan 9 39 2.32630161961136 NA 2.49748085241436 3.02029814931558 -0.522817296901223 1.99491171562545 1.55628138689219 0.318595093103832 0.262075405546108 0.33594008211154 0.393413320510147 NA NA NA 0.47793020441149 99.1799006790114 a4594 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 205 BMS-708163 g-secretase 5 43 2.32630161961136 0.940007258491471 4.64924644423382 4.92528336336216 -0.276036919128343 0.92795842312805 0.650026010387855 0.406697894452458 0.297466903956593 0.424655190280214 0.393847154416874 NA NA NA 0.549409469021076 99.2676578361555 a4595 gain_cnaBRCA12_(TERT) 1133 JNJ-26854165 MDM2 10 33 2.30258509299405 NA 3.17691220153283 2.90575625942787 0.271155942104962 0.806376332424221 0.889465814900441 0.31099245262658 0.33626475778348 0.304852572816767 0.393954666408701 NA NA NA 0.376682668841619 99.2731465146104 a4596 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 196 Phenformin AAPK1 (AMPK) agonist 8 40 8.29404964010203 NA 7.70478140404267 7.101459420052 0.603321983990666 0.723510148273516 1.94258160964128 0.333177888062282 0.833881854221879 0.310577419757452 0.394106435229696 NA NA NA 0.141529921834418 99.2750544788424 a4597 NF1_mut 292 Masitinib KIT 4 44 2.99573227355399 NA 3.56215326246971 4.05107048311046 -0.488917220640752 0.424275250813721 1.1208356626294 0.448929418892813 1.15235856841297 0.436207766171347 0.394448595421509 NA NA NA 0.110077008885669 99.2750544788424 a4598 gain_cnaBRCA27_(CLTC,PPM1D) 157 JNK-9L JNK 9 38 1.63315443905142 NA -0.216109190388676 0.120254334508441 -0.336363524897117 1.08312269295107 1.04919461049543 0.318735538971189 0.310549790052559 0.320592120405848 0.394459873833974 NA NA NA 0.416114509251741 99.2750544788424 a4599 gain_cnaBRCA8_(CHD4,WNK1) 1170 CCT018159 HSP90 3 40 2.30258509299405 NA 2.77230805149023 3.38561743716416 -0.613309385673929 0.933944400517765 1.20236883882199 0.515091819515616 0.656687256044278 0.51008423195233 0.394528283253122 NA NA NA 0.375067592508114 99.2750544788424 a4600 POLR2B_mut 176 IPA-3 PAK1, PAK2, PAK3 3 44 3.46573590279973 NA 3.77227999823372 4.54624123080616 -0.773961232572437 2.19990394621515 1.46876769841657 0.51296314019938 0.351815920828729 0.526945978868421 0.394535915856986 NA NA NA 0.60613669622295 99.2750544788424 a4601 TP53_mut 1170 CCT018159 HSP90 34 9 2.30258509299405 NA 3.42319786212527 3.03921048097535 0.383987381149921 1.20954779076771 1.10948752337523 0.322493022733673 0.317463587698508 0.346094366146427 0.394629963415899 NA NA NA 0.381043909874767 99.2750544788424 a4602 loss_cnaBRCA34 1054 PD-0332991 CDK4, CDK6 5 37 1.38629436111989 0.693147180559945 3.41180837389912 2.8114312740477 0.600377099851424 0.740848065278637 1.52420379749184 0.409857828089088 0.810391668669093 0.393895554412983 0.394810793066644 NA NA NA 0.180419103067517 99.2750544788424 a4603 loss_cnaBRCA24 221 TAK-715 p38a 3 46 2.99573227355399 2.32630161961136 3.99877120399942 4.5136775949758 -0.514906390976384 0.242873657182555 1.02709045782802 0.51170925938868 2.1200586220405 0.501325260157956 0.394839207465306 NA NA NA 0.0345613583090858 99.2750544788424 a4604 loss_cnaBRCA57 1016 Temsirolimus MTOR 5 39 -1.6094379124341 NA -2.29304293301414 -1.68144070605133 -0.611602226962809 1.48304471217492 1.49934933255552 0.40833257373912 0.412396350522622 0.407911761244046 0.39488035121366 NA NA NA 0.424748619878504 99.2750544788424 a4605 gain_cnaBRCA48 1020 Lenalidomide TNFA 5 40 1.6094379124341 NA 4.51195788353484 4.22257266355281 0.289385219982032 0.40028215296691 0.73440581370523 0.407591141712598 0.722953091555781 0.394039936206419 0.394952566218821 NA NA NA 0.212375324418031 99.2750544788424 a4606 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 135 Gemcitabine DNA replication 5 42 0.0237165266173161 NA 0.727737105776309 -0.394623829200293 1.1223609349766 3.00747088093424 2.73716398581634 0.406319420095413 0.373190956591391 0.410045193051109 0.394963372758604 NA NA NA 0.463310602749206 99.2750544788424 a4607 gain_cnaBRCA30_(CRNKL1,FOXA2) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 5 40 0.693147180559945 NA 1.1453815651862 0.560592342001894 0.584789223184303 1.16413261567803 1.46005976691419 0.407487904648043 0.502339007866131 0.400524167870363 0.395071288475626 NA NA NA 0.346048705266347 99.2750544788424 a4608 gain_cnaBRCA48 290 KIN001-260 IKK 5 44 2.99573227355399 NA 5.42288891129622 5.00102644452469 0.421862466771534 0.497587607708825 1.07826437407095 0.405042636865774 0.847815460505594 0.391242145169655 0.395109992480664 NA NA NA 0.159565190578152 99.2750544788424 a4609 PTEN_mut 1219 PFI-1 BRD2, BRD3, BRD4 8 39 2.30258509299405 NA 2.89667334013392 3.2290570054735 -0.332383665339585 0.604480561694043 1.0540628694503 0.333207999436739 0.549866590264024 0.315335711913394 0.395162558159586 NA NA NA 0.238716111437453 99.2750544788424 a4610 loss_cnaBRCA33 1047 Nutlin-3a MDM2 5 38 2.07944154167984 1.38629436111989 3.8440535733419 4.25469338315287 -0.410639809810973 1.25322097073002 0.974038503251134 0.408720151044316 0.327667521851131 0.421584781751793 0.395253676022936 NA NA NA 0.514371476362937 99.2764059581253 a4611 gain_cnaBRCA58_(CCND1) 151 QS11 ARFGAP 9 39 2.32630161961136 NA 4.14188723341282 3.67242589106546 0.469461342347357 1.24865038529093 1.52452616376511 0.31715094906568 0.375975011001959 0.307939183666046 0.395544365229254 NA NA NA 0.346987007415992 99.311357293691 a4612 PIK3CA_mut 119 Lapatinib ERBB2, EGFR 4 9 0.693147180559945 NA 0.616825583763567 1.80907892728128 -1.19225334351771 3.05866145466159 1.8498788385025 0.531059188276659 0.389795785244766 0.644503477040074 0.395743258935317 NA NA NA 0.509537067213694 99.311357293691 a4613 gain_cnaBRCA63 1091 BMS-536924 IGF1R 6 41 1.38629436111989 NA 3.38084861554521 2.97097835631388 0.409870259231333 0.872162977286224 1.11871354646944 0.374630207740649 0.469946867621764 0.36637641559347 0.395942166486469 NA NA NA 0.332997262719077 99.311357293691 a4614 POLR2B_mut 268 YM155 BIRC5 (Survivin) 3 46 1.63315443905142 NA -2.83000396599163 -3.6455067434541 0.815502777462467 2.33813999848663 1.55666111202866 0.510416182240299 0.348782698208962 0.523879456588785 0.39602560770427 NA NA NA 0.608932284126361 99.311357293691 a4615 gain_cnaBRCA62 295 NVP-BHG712 EPHB4 10 39 2.32630161961136 NA 3.58986872654247 3.9628209512217 -0.37295222467923 2.07593024814046 0.919851419773076 0.303572257665009 0.179655470126372 0.405448332917979 0.396100720823929 NA NA NA 0.591620565656473 99.311357293691 a4616 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1219 PFI-1 BRD2, BRD3, BRD4 9 38 2.30258509299405 NA 3.42864919697812 3.11180966215092 0.316839534827207 1.09486891721826 0.975242617684149 0.317614983426755 0.289385815821865 0.324882782070771 0.396110819461799 NA NA NA 0.442272312243845 99.311357293691 a4617 PTEN_mut 222 BX-912 PDPK1 (PDK1) 9 40 2.32630161961136 NA 3.49400220136843 3.97148096003262 -0.477478758664186 1.78085959415832 1.44973864440728 0.315953330096545 0.268117015081054 0.329355060311164 0.39612251840193 NA NA NA 0.469499339017267 99.311357293691 a4618 BRCA2_mut 1164 XMD8-92 MAP2K5 (ERK5) 3 23 2.30258509299405 NA 3.27403439588097 3.96411349859865 -0.690079102717679 1.63816357768354 1.26600858821061 0.530383898070687 0.421251645512404 0.545082481385884 0.396125621637681 NA NA NA 0.546009792843948 99.311357293691 a4619 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 308 XL-880 MET 15 34 1.63315443905142 NA 2.14310532543526 1.71741621013404 0.425689115301217 1.23288037666723 1.73738055589709 0.265427587544319 0.345280145063185 0.245017773369412 0.396168969130298 NA NA NA 0.335222119913722 99.311357293691 a4620 loss_cnaBRCA29_(MAP2K4) 1025 SB 216763 GSK3A, GSK3B 6 33 2.30258509299405 NA 5.14261717675263 4.84307845260653 0.299538724146097 0.615088193879669 0.809846135911665 0.380922253351996 0.48698500008065 0.36987115312824 0.396255682961277 NA NA NA 0.326895686043866 99.311357293691 a4621 PTEN_mut 205 BMS-708163 g-secretase 9 39 2.32630161961136 0.940007258491471 5.07112161258284 4.85623903416657 0.214882578416264 0.570486157505336 0.69945198438315 0.316569164567204 0.376665718509138 0.30721562482344 0.396404905020748 NA NA NA 0.346569473208174 99.311357293691 a4622 gain_cnaBRCA10_(MDM2,NUP107) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 3 42 2.30258509299405 NA 0.838935931944756 1.40292316414409 -0.563987232199334 1.26966536335781 1.09302976005632 0.511843938923388 0.444201478969065 0.515985248352498 0.39648101562232 NA NA NA 0.524840861107289 99.311357293691 a4623 loss_cnaBRCA33 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 5 42 2.32630161961136 NA 0.862735162995099 1.48291259906354 -0.620177436068437 0.799663053386649 1.58561554193345 0.404771475191041 0.775548443112292 0.391127243437719 0.396752099004731 NA NA NA 0.188318701465513 99.311357293691 a4624 loss_cnaBRCA29_(MAP2K4) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 7 42 3.68887945411394 NA 3.10193902262057 3.5190452158786 -0.417106193258027 0.786975233750372 1.24332909891474 0.349096515132032 0.530011842012214 0.335475292601215 0.396829308499142 NA NA NA 0.261973974268019 99.311357293691 a4625 gain_cnaBRCA12_(TERT) 268 YM155 BIRC5 (Survivin) 9 40 1.63315443905142 NA -4.00703760179113 -3.50299959201859 -0.504038009772545 1.2569511579533 1.65904336933294 0.315464564966833 0.401000473712337 0.303812437389872 0.39684802061539 NA NA NA 0.324031792751415 99.311357293691 a4626 gain_cnaBRCA31 111 Salubrinal GADD34-PP1C 4 9 2.77258872223978 NA 3.64346063049021 3.05624731957405 0.587213310916161 1.25745009718581 1.04895896224679 0.529158422435366 0.466987367713719 0.559805799893636 0.397380357199781 NA NA NA 0.451733694963022 99.311357293691 a4627 ARID1A_mut 176 IPA-3 PAK1, PAK2, PAK3 4 43 3.46573590279973 NA 3.88051301739469 4.55417214140915 -0.67365912401446 2.14854908653642 1.45254218876429 0.446438290922415 0.313541416500954 0.463779385704146 0.397608110361437 NA NA NA 0.579329152710968 99.311357293691 a4628 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1218 JQ1 BRD2, BRD3, BRD4 6 40 0 NA 2.68619243912151 2.42375028694019 0.26244215218132 0.256983106190627 0.739770900513894 0.373935421291256 1.02124282047802 0.354761388963813 0.397660191931792 NA NA NA 0.109706140547709 99.311357293691 a4629 MLL3_mut 266 Zibotentan, ZD4054 Endothelin A Receptor 3 46 2.99573227355399 NA 5.50703691738725 5.75736563235837 -0.250328714971115 0.471537650992653 0.493215440046192 0.50847531289529 0.530877469580929 0.507544360224551 0.397810524003939 NA NA NA 0.45750299765284 99.311357293691 a4630 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 295 NVP-BHG712 EPHB4 6 43 2.32630161961136 NA 3.48579020762581 3.94265030505387 -0.456860097428059 0.96856401705272 1.25599227764747 0.37184962443703 0.471688075733244 0.36374435222148 0.397845259385444 NA NA NA 0.330480548259377 99.311357293691 a4631 loss_cnaBRCA38 197 Bryostatin 1 PRKC 4 44 -4.8283137373023 NA -2.41213935286739 -2.84268252038358 0.430543167516195 0.341310163497518 0.99519366470533 0.445634832649392 1.26144256328109 0.432622496289379 0.397900410361652 NA NA NA 0.090454812443334 99.311357293691 a4632 loss_cnaBRCA18 1031 Elesclomol HSP70 14 30 -1.6094379124341 NA -2.64123532176263 -3.1345394866812 0.493304164918567 1.55118606651717 1.87994750427595 0.276411752501507 0.318017403306212 0.262403159554479 0.397953101805229 NA NA NA 0.366566064041582 99.311357293691 a4633 loss_cnaBRCA36_(FAT1,IRF2) 153 Midostaurin KIT 9 38 -0.669430653942629 NA 0.240048016275455 0.700321549667654 -0.4602735333922 1.07748631632607 1.52451213549695 0.316314682872462 0.427173437303229 0.301915296490679 0.398031985699915 NA NA NA 0.306337022905162 99.311357293691 a4634 gain_cnaBRCA62 1043 JNK Inhibitor VIII JNK 7 36 2.30258509299405 NA 5.01759033875358 4.75450301164758 0.263087327106008 1.14814416510468 0.652262561919407 0.352796356880824 0.229141370136232 0.40334574213768 0.398032576640437 NA NA NA 0.575555937730391 99.311357293691 a4635 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1004 Vinblastine Microtubules 17 28 -2.30258509299405 NA -3.24605278438076 -3.58276138106392 0.336708596683155 1.35416531581559 1.23872639736327 0.262460090608681 0.24864659635767 0.271818375227868 0.398050379210833 NA NA NA 0.410086103140864 99.311357293691 a4636 POLR2B_mut 276 CAY10603 HDAC6 3 46 2.99573227355399 NA 1.64849831398056 1.14469462135457 0.503803692625986 1.38976864387842 0.970026311346986 0.508115505164745 0.362509036914247 0.51937116213518 0.398141969505091 NA NA NA 0.596125884294418 99.311357293691 a4637 gain_cnaBRCA63 1241 CHIR-99021 GSK3B 6 40 2.30258509299405 NA 4.54892939283533 4.18387074743468 0.365058645400648 0.892549965846669 0.987711022350858 0.373513498707076 0.409006396694391 0.369600659646148 0.398188543935674 NA NA NA 0.387868833767398 99.311357293691 a4638 loss_cnaBRCA57 1494 SN-38 TOP1 5 43 -2.99573227355399 NA -2.69629838572057 -3.37442689645882 0.67812851073825 0.740615510236312 1.74646614098228 0.402919751702026 0.915628286696124 0.388286090881124 0.398221276204786 NA NA NA 0.140415769660082 99.311357293691 a4639 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 192 LFM-A13 BTK 6 42 2.77258872223978 NA 4.52324928496656 4.83435881558993 -0.31110953062337 0.878535547867777 0.831279162374563 0.371898119829499 0.354122871155799 0.374253974723341 0.39855917202703 NA NA NA 0.443630678748173 99.311357293691 a4640 loss_cnaBRCA18 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 15 31 0 NA 1.02512206910965 0.4732601823465 0.551861886763146 1.71436494215398 2.20149627051404 0.268019148800691 0.32190455672161 0.250675821782922 0.398748315176009 NA NA NA 0.358865744725353 99.311357293691 a4641 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1047 Nutlin-3a MDM2 5 38 2.07944154167984 1.38629436111989 4.56714815717087 4.15954935896485 0.407598798206016 0.83961788739612 1.02109110069326 0.405639477652353 0.485457497183736 0.399179659806341 0.398794141480603 NA NA NA 0.360998626545798 99.311357293691 a4642 CDH1_mut 1371 PLX4720 (rescreen) BRAF 5 42 2.30258509299405 NA 5.051385173506 4.66616664976301 0.385218523742992 0.641586156233739 0.981450976036989 0.402887035474115 0.60041589114752 0.392498997044631 0.3989364690158 NA NA NA 0.27672896019468 99.311357293691 a4643 loss_cnaBRCA29_(MAP2K4) 1047 Nutlin-3a MDM2 5 38 2.07944154167984 1.38629436111989 3.84685970870291 4.2543241548159 -0.407464446112987 1.30616507379608 0.966649943311883 0.405503401570023 0.311954786027758 0.421522236598861 0.398950982280992 NA NA NA 0.532889917493323 99.311357293691 a4644 gain_cnaBRCA15 163 JQ1 BRD4 22 25 0.940007258491471 NA 0.50893848843435 0.146057609996258 0.362880878438091 1.3935959323696 1.5118302808897 0.248915434084101 0.260391746279761 0.240027523608364 0.399000849316158 NA NA NA 0.396530212307275 99.311357293691 a4645 TP53_mut 38 AZD-0530 SRC, ABL1 9 5 0.693147180559945 NA 2.70024312601087 2.38171032910238 0.318532796908488 0.587112621851378 0.768233206911076 0.487730886923542 0.542541217908141 0.41463034146786 0.399049626426611 NA NA NA 0.448246694195945 99.311357293691 a4646 gain_cnaBRCA47_(EGFR) 231 FMK RSK 7 42 2.99573227355399 2.32630161961136 5.41258995510271 5.61866965441163 -0.206079699308927 0.234170226270099 0.628842546002731 0.347366421933117 0.880042277754084 0.327712716989146 0.399155553566272 NA NA NA 0.12970645032647 99.311357293691 a4647 BRCA1_mut 1199 Tamoxifen ER 4 43 1.6094379124341 NA 4.25691564512014 3.83310088063503 0.423814764485107 0.756241895879412 0.965377926157146 0.444779610994139 0.5604222230934 0.439014351790884 0.399349887182304 NA NA NA 0.355616503859124 99.311357293691 a4648 gain_cnaBRCA12_(TERT) 1114 Cetuximab EGFR 9 36 4.18661983833127 NA 6.05990582832756 6.33825486183446 -0.278349033506899 0.689149584906351 0.915114088232036 0.317210079211282 0.403902200049535 0.304168668241856 0.399393563285797 NA NA NA 0.327865458708756 99.311357293691 a4649 NF1_mut 152 CP466722 ATM 5 44 2.77258872223978 NA 2.34777086580267 2.77359299873117 -0.425822132928494 1.06558762607629 1.06066715844593 0.401307535756636 0.399612497844459 0.401466312535215 0.399449492369312 NA NA NA 0.435981083891212 99.311357293691 a4650 loss_cnaBRCA28_(GPS2) 1005 Cisplatin DNA crosslinker 3 42 1.79175946922805 2.30258509299405 4.23122580429015 3.63000196210729 0.601223842182853 0.854607392693902 1.19601771727767 0.508509253707661 0.703508824429507 0.502688073510597 0.399539259796994 NA NA NA 0.348015375677453 99.311357293691 a4651 loss_cnaBRCA28_(GPS2) 253 XMD14-99 EPHB3, CAMK1 4 44 2.32630161961136 NA 5.24769191288241 4.90450274270848 0.343189170173932 0.222029516277271 0.7972701856324 0.444018393688568 1.54569165365093 0.430455291516654 0.399600846439845 NA NA NA 0.0561988727225912 99.311357293691 a4652 CDH1_mut 165 DMOG Prolyl-4-Hydroxylase 4 42 8.29404964010203 NA 8.19353266606945 7.51059466471984 0.682938001349618 1.37197757846518 1.5459191413085 0.445001814399788 0.497776357332031 0.441768254949973 0.399691458426883 NA NA NA 0.403368844005905 99.311357293691 a4653 loss_cnaBRCA38 291 KIN001-266 MAP3K8 (COT) 4 45 2.99573227355399 NA 3.29855848312364 3.82130782459183 -0.52274934146819 0.649308266803948 1.20734983220403 0.443141595157244 0.805086533152102 0.43297255486747 0.399998663031372 NA NA NA 0.217057373772395 99.311357293691 a4654 gain_cnaBRCA15 333 T0901317 LXR 22 26 2.32630161961136 NA 4.83730705699721 4.64923779367258 0.188069263324635 0.874197812147516 0.657962054279869 0.246065487874872 0.215133532378253 0.285836032794437 0.4000408024624 NA NA NA 0.411856615523151 99.311357293691 a4655 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1036 PLX4720 BRAF 16 27 2.30258509299405 NA 4.79910390760461 4.47662265504913 0.322481252555477 0.973508183743649 1.3158535922106 0.268293920639324 0.331256848109245 0.245073809475808 0.400046969846306 NA NA NA 0.364208613841331 99.311357293691 a4656 gain_cnaBRCA64_(SDHC) 185 OSI-906 IGF1R 8 40 0.940007258491471 NA 3.20240117321929 2.83170766047215 0.37069351274714 0.955569834079463 1.15584502426501 0.328726563639297 0.387929274791563 0.32071212400024 0.400405679144636 NA NA NA 0.354330543430485 99.311357293691 a4657 ARID1A_mut 269 NSC-207895 MDM4 5 44 2.99573227355399 NA 4.17686782122333 4.65247360157131 -0.475605780347982 1.21181916446088 1.18542946293667 0.400443286943935 0.392472568759525 0.401209684100277 0.400457791647762 NA NA NA 0.443219086324362 99.311357293691 a4658 loss_cnaBRCA36_(FAT1,IRF2) 1129 PF-4708671 RPS6KB1 (p70S6KA) 9 34 2.30258509299405 NA 4.09719330977126 3.73267170341049 0.36452160636077 0.656178916478901 1.23426180631867 0.318463731618289 0.55552166826209 0.295335725771179 0.400511595046427 NA NA NA 0.242425776966871 99.311357293691 a4659 loss_cnaBRCA34 333 T0901317 LXR 5 43 2.32630161961136 NA 4.46093379139843 4.76735509145195 -0.306421300053519 0.730736651447323 0.76744057708033 0.400907655270747 0.419332052725986 0.399276907170163 0.400563057467914 NA NA NA 0.417150613412953 99.311357293691 a4660 loss_cnaBRCA7_(FAS,PTEN) 1054 PD-0332991 CDK4, CDK6 4 38 1.38629436111989 0.693147180559945 3.47494356136488 2.82058486220528 0.654358699159597 0.985329264824399 1.49734889204753 0.446610226985724 0.664101557235503 0.43701150923136 0.400591938847425 NA NA NA 0.291198561523507 99.311357293691 a4661 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 152 CP466722 ATM 7 42 2.77258872223978 NA 2.41519106975558 2.78263354249751 -0.367442472741938 0.350700304799622 1.12817170421011 0.346275622341688 1.04773924548449 0.325697295341405 0.400626563513355 NA NA NA 0.103127487542292 99.311357293691 a4662 ARID1A_mut 294 MPS-1-IN-1 MPS1 5 44 2.99573227355399 NA 4.33526368902222 4.80438747726464 -0.469123788242414 1.26417760928608 1.16321395379918 0.400226676364887 0.371090094300391 0.403299656705636 0.400710753460139 NA NA NA 0.465377819522509 99.311357293691 a4663 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 6 39 2.30258509299405 NA 1.00987890731476 1.4200078781025 -0.410128970787742 1.26402629477158 1.07891908223332 0.372153728584116 0.324462372724498 0.380129499553192 0.40078078525977 NA NA NA 0.478806905375949 99.311357293691 a4664 gain_cnaBRCA19 302 PI-103 PI3Ka, PRKDC (DNAPK) 4 44 2.32630161961136 NA 0.375981425040935 1.19683786252872 -0.820856437487786 1.03889046703633 1.89744646751315 0.442840792494582 0.79012799090309 0.43261111791134 0.400842479111704 NA NA NA 0.224192960697667 99.311357293691 a4665 gain_cnaBRCA47_(EGFR) 1377 Afatinib (rescreen) ERBB2, EGFR 7 40 2.30258509299405 NA 2.24684600746232 2.93750410144727 -0.690658093984943 1.75802925464287 2.02071930347696 0.347465819268396 0.392859272484202 0.341788239859222 0.400876258553514 NA NA NA 0.373289076508002 99.311357293691 a4666 gain_cnaBRCA62 135 Gemcitabine DNA replication 8 39 0.0237165266173161 NA 0.479341918842174 -0.43000642687867 0.909348345720844 3.07451308886739 2.70148574847384 0.329137492066164 0.295769872964124 0.33661045453768 0.400915478517255 NA NA NA 0.456212221681429 99.311357293691 a4667 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1192 GSK269962A ROCK1, ROCK2 9 37 1.6094379124341 NA 2.29710787972837 2.75814693069116 -0.461039050962787 2.03094782542619 1.30411097633776 0.31505377806362 0.227006841431802 0.353527467622033 0.4012082386695 NA NA NA 0.531309320921117 99.311357293691 a4668 BRCA1_mut 229 LY317615 PRKCB (PKCbeta) 4 45 2.99573227355399 2.32630161961136 2.70375638481693 3.41678988864464 -0.71303350382771 1.88368553933424 1.59352220524869 0.441889057462815 0.378531070573341 0.44745752615128 0.401321912950812 NA NA NA 0.510372014020451 99.311357293691 a4669 gain_cnaBRCA62 333 T0901317 LXR 10 38 2.32630161961136 NA 4.55329832721868 4.78336722676945 -0.230068899550774 0.866862054681683 0.737250402866197 0.301003119372783 0.265404280079206 0.312063443649998 0.40142475089315 NA NA NA 0.455875038159415 99.311357293691 a4670 gain_cnaBRCA12_(TERT) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 10 36 1.38629436111989 NA 2.50762580738705 2.95610464301956 -0.448478835632509 1.25478984974553 1.53381835239051 0.302816061753176 0.357413502925178 0.29239370811644 0.401505763237023 NA NA NA 0.355162477208265 99.311357293691 a4671 gain_cnaBRCA61_(NOTCH2) 165 DMOG Prolyl-4-Hydroxylase 3 43 8.29404964010203 NA 6.84425287726547 7.62061274303987 -0.776359865774404 0.984450369425506 1.55614220876958 0.50584342073586 0.788622656749534 0.498900332758315 0.401526406157914 NA NA NA 0.30371316999591 99.311357293691 a4672 gain_cnaBRCA19 272 AR-42 HDAC 4 45 1.63315443905142 NA -0.478550654420666 0.197125889173206 -0.675676543593872 0.732748827289062 1.56945968123125 0.441680031380814 0.9221120777411 0.430515387986137 0.401543003464684 NA NA NA 0.172108597433649 99.311357293691 a4673 ARID1A_mut 333 T0901317 LXR 5 43 2.32630161961136 NA 4.46152888468661 4.76728589455797 -0.305757009871362 0.638563195564764 0.775260410394402 0.400024970911962 0.478820282777089 0.394392652806575 0.401593062529064 NA NA NA 0.364234222076715 99.311357293691 a4674 loss_cnaBRCA38 309 Y-39983 ROCK 4 45 2.99573227355399 NA 4.4958296024503 4.97401660056784 -0.478186998117542 1.16804292459751 1.07716263015957 0.441461245921225 0.409391631118623 0.443932034707428 0.401774497446822 NA NA NA 0.480256848163064 99.311357293691 a4675 ASH1L_mut 219 AT-7519 CDK9 3 46 2.32630161961136 NA 2.52917565255777 1.61609777624511 0.913077876312662 1.18851211422967 1.83459876567385 0.503960290291588 0.768252898208334 0.497698948345955 0.401982077019237 NA NA NA 0.313551572869539 99.311357293691 a4676 ASH1L_mut 224 AS605240 PI3Kgamma 3 46 2.99573227355399 2.32630161961136 4.0179049714589 3.22149708266288 0.796407888796017 1.15102315051363 1.59684947786915 0.503914603553593 0.691913006650324 0.49873698168393 0.40202442622657 NA NA NA 0.354217269851836 99.311357293691 a4677 gain_cnaBRCA8_(CHD4,WNK1) 330 XMD13-2 RIPK 4 44 2.32630161961136 NA 3.22874505539833 3.76577362513756 -0.53702856973923 1.86198035564649 1.15797641775776 0.441499567922251 0.288417956779556 0.463764685967527 0.402259544103564 NA NA NA 0.607938782699398 99.311357293691 a4678 gain_cnaBRCA64_(SDHC) 1218 JQ1 BRD2, BRD3, BRD4 9 37 0 NA 2.63545816247087 2.41481196351618 0.220646198954684 0.912150120713288 0.646016737001164 0.314333141263515 0.24189680398457 0.34154873444755 0.402277548029064 NA NA NA 0.508792265285781 99.311357293691 a4679 loss_cnaBRCA17 268 YM155 BIRC5 (Survivin) 11 38 1.63315443905142 NA -3.95412720824469 -3.49178744226768 -0.46233976597701 1.57170181252895 1.60509786994178 0.289314815901863 0.294165065085139 0.288044595058731 0.402387579396061 NA NA NA 0.404731369883669 99.311357293691 a4680 loss_cnaBRCA23 300 CX-5461 RNA Pol I 3 46 2.32630161961136 NA 4.71959472691991 3.85971989537397 0.859874831545939 0.292269746582956 1.74421063221105 0.503510076315893 2.94205897667851 0.492987954359571 0.402399522241159 NA NA NA 0.0120350473877562 99.311357293691 a4681 loss_cnaBRCA18 111 Salubrinal GADD34-PP1C 5 8 2.77258872223978 NA 2.89770276507429 3.44894432159449 -0.551241556520202 0.550430196734079 1.3284833672139 0.496378390696849 1.0014740466474 0.414940502925728 0.402517368551513 NA NA NA 0.322933738240843 99.311357293691 a4682 gain_cnaBRCA27_(CLTC,PPM1D) 326 GSK690693 AKT 9 39 2.32630161961136 NA 2.45003463719279 3.05254985358243 -0.602515216389643 2.59531144495406 1.75748432409301 0.312263995664819 0.232155265049628 0.342828216519419 0.402809062215345 NA NA NA 0.523107604864511 99.311357293691 a4683 gain_cnaBRCA64_(SDHC) 226 GSK1070916 AURKB 8 41 0.940007258491471 2.32630161961136 2.93567959787553 2.30019514556705 0.635484452308483 1.35588923718189 2.03353184624291 0.326289890033417 0.468684635058605 0.312502827768636 0.402837308508393 NA NA NA 0.287710038623529 99.311357293691 a4684 PIK3CA_mut 1004 Vinblastine Microtubules 16 29 -2.30258509299405 NA -3.6730648523557 -3.33555787470936 -0.337506977646349 1.56876191706881 1.09999441163958 0.263036552978206 0.215142255796834 0.306826083910085 0.402989942392531 NA NA NA 0.452964939484452 99.311357293691 a4685 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1502 Bicalutamide ANDR (androgen receptor) 13 32 2.30258509299405 NA 4.44306330099267 4.60511931468119 -0.162056013688519 0.511401226274551 0.609014627163116 0.277769559455478 0.316886243838448 0.266095437548685 0.403036969494884 NA NA NA 0.371011517123904 99.311357293691 a4686 loss_cnaBRCA36_(FAT1,IRF2) 89 Parthenolide NFKB1 3 11 1.6094379124341 NA 3.87297834812507 3.07992581017548 0.793052537949595 0.408107450092614 1.52865404540732 0.564299726894126 1.94324445135619 0.518791377507709 0.40327834235587 NA NA NA 0.151739926390327 99.311357293691 a4687 gain_cnaBRCA64_(SDHC) 1378 Bleomycin (50 uM) DNA damage 9 39 3.91202300542815 NA 4.29054343459015 3.70245011591999 0.588093318670158 1.79407867259238 1.90453829162314 0.311854692178434 0.327796839488864 0.308785242731433 0.403421239092728 NA NA NA 0.397493423467803 99.311357293691 a4688 gain_cnaBRCA47_(EGFR) 1091 BMS-536924 IGF1R 7 40 1.38629436111989 NA 2.70146109806878 3.07962441539147 -0.378163317322695 1.18495134386258 1.07972942237122 0.345561739015904 0.319138266124917 0.350238966807258 0.403441981134932 NA NA NA 0.453303505808489 99.311357293691 a4689 PIK3CA_mut 106 XMD8-85 MAP2K5 (ERK5) 4 9 2.07944154167984 NA 3.66435348007049 3.02836735930047 0.635986120770017 0.993975258488366 1.29268723497861 0.52193994535201 0.639840997387825 0.491987623580535 0.403639892741246 NA NA NA 0.363377048143933 99.311357293691 a4690 BRCA1_mut 171 AKT inhibitor VIII AKT1, AKT2, AKT3 4 43 0.940007258491471 NA 2.39386529816062 1.84166273932628 0.552202558834334 0.784576313159058 1.28011498935457 0.440637504963026 0.703822623207828 0.431369496823683 0.403720182406741 NA NA NA 0.267133150654056 99.311357293691 a4691 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 344 THZ-2-49 CDK9 9 40 2.99573227355399 NA 1.41144114456213 1.86938761180821 -0.457946467246085 0.892137005905089 1.5665294600262 0.310746629139505 0.51331405850774 0.292331857735013 0.403893596046541 NA NA NA 0.249997905384773 99.311357293691 a4692 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 275 I-BET BRD2, BRD3, BRD4 9 40 2.99573227355399 NA 4.38367249725385 3.96137648579932 0.422296011454528 1.2950876965904 1.37192936829302 0.310704417237293 0.326075224532142 0.307811773123537 0.403956980535884 NA NA NA 0.398702885422439 99.311357293691 a4693 gain_cnaBRCA63 152 CP466722 ATM 7 42 2.77258872223978 NA 2.41757865334675 2.78223561189898 -0.364656958552232 0.519547355928636 1.11873437085607 0.343610850494304 0.70187434194607 0.325954907663372 0.404234284520875 NA NA NA 0.180716221819347 99.311357293691 a4694 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 179 5-Fluorouracil DNA antimetabolite 9 40 3.46573590279973 NA 4.45160763242921 3.94919722556952 0.502410406859688 0.90791927518322 1.72809421462841 0.310490285326476 0.553364622376037 0.290730911895171 0.404278611081174 NA NA NA 0.23022070711125 99.311357293691 a4695 gain_cnaBRCA58_(CCND1) 228 KIN001-102 AKT1 10 39 2.32630161961136 NA 1.60983727090094 2.02931034600041 -0.419473075099474 1.41427911014237 1.40482768385023 0.2982087422874 0.296598508803009 0.298593969866695 0.404436058746715 NA NA NA 0.416241311310503 99.311357293691 a4696 loss_cnaBRCA38 1031 Elesclomol HSP70 3 41 -1.6094379124341 NA -2.13970317716342 -3.03888706277128 0.899183885607862 1.79260755753347 1.78471266811581 0.503719243465521 0.501606657758986 0.5038255746552 0.404446877387924 NA NA NA 0.479672068250915 99.311357293691 a4697 gain_cnaBRCA48 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 5 44 1.63315443905142 NA 3.93303022249643 3.53615992952278 0.396870292973652 0.401567678317145 1.03817093170399 0.396910921889017 0.988302381896923 0.38227837136824 0.404595308461473 NA NA NA 0.12211690831681 99.311357293691 a4698 loss_cnaBRCA60 135 Gemcitabine DNA replication 3 44 0.0237165266173161 NA -1.57363541228178 -0.186695660470123 -1.38693975181165 1.88038350661823 2.79745955435657 0.501937651678636 0.737583448764658 0.495785452787595 0.404696197479545 NA NA NA 0.329508806851487 99.311357293691 a4699 gain_cnaBRCA64_(SDHC) 299 OSI-027 MTORC1/2 8 40 2.99573227355399 NA 0.73047099016271 1.37666927832399 -0.64619828816128 1.10162778798725 2.10441047731828 0.325578485338056 0.586584956559535 0.307068556788764 0.40489816279898 NA NA NA 0.222317416139369 99.311357293691 a4700 TP53_mut 1375 Temozolomide DNA akylating agent 36 10 3.40119738166216 NA 5.94573804919964 5.73592232579737 0.209815723402278 0.657348894981346 0.837537979398885 0.300595467867591 0.319184720631853 0.250514876415356 0.40493955479949 NA NA NA 0.477915406370098 99.311357293691 a4701 POLR2B_mut 1024 CEP-701 FLT3, JAK2, NTRK1, RET 3 42 0.693147180559945 NA 1.29906767297066 0.577461868740352 0.721605804230308 2.30791000304246 1.37901547201218 0.502647641664312 0.31266635322826 0.523276075486941 0.404950438810294 NA NA NA 0.64397584202944 99.311357293691 a4702 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 5 38 0.693147180559945 NA 3.2465163997979 2.86393215321579 0.38258424658211 0.406686417186815 0.997118030887939 0.400314314704996 0.940735245668082 0.383690029395434 0.404960600212248 NA NA NA 0.141931872229393 99.311357293691 a4703 loss_cnaBRCA22_(SYNCRIP,ZNF292) 111 Salubrinal GADD34-PP1C 3 10 2.77258872223978 NA 2.74987909567853 3.38304311110917 -0.633164015430643 0.606834264112403 1.19439916829147 0.569940936253186 1.04338870244374 0.530110897796719 0.405086609115101 NA NA NA 0.257756438289401 99.311357293691 a4704 POLR2B_mut 1175 AG-014699 PARP1, PARP2 3 40 1.6094379124341 NA 3.38082650625227 3.89762645922553 -0.516799952973261 2.06557309315602 0.942686682856331 0.503522058038693 0.250196884673606 0.548220275486827 0.405141620397955 NA NA NA 0.707956443573455 99.311357293691 a4705 gain_cnaBRCA13_(FGFR1,WHSC1L1) 136 Mitomycin C DNA crosslinker 10 38 2.77258872223978 NA 0.215170709468361 -0.226272652870851 0.441443362339212 1.33379349475774 1.5116388296309 0.298569652385507 0.330968297621958 0.292029652643284 0.405212916216831 NA NA NA 0.379262943338935 99.311357293691 a4706 gain_cnaBRCA14_(RAD21) 295 NVP-BHG712 EPHB4 21 28 2.32630161961136 NA 4.05696590329842 3.75901501406444 0.297950889233981 1.32534174140964 1.15228192058347 0.242451978304406 0.224810612934502 0.258574645589433 0.405228776145868 NA NA NA 0.41542584093927 99.311357293691 a4707 loss_cnaBRCA36_(FAT1,IRF2) 287 KIN001-244 PDPK1 (PDK1) 9 40 2.99573227355399 NA 3.71653551878649 3.42445940954809 0.292076109238397 0.995002905745334 0.931635443998811 0.309822019628253 0.293542971132943 0.313509013766945 0.405283376452894 NA NA NA 0.437419264888731 99.311357293691 a4708 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1054 PD-0332991 CDK4, CDK6 5 37 1.38629436111989 0.693147180559945 3.40020314830419 2.81299954777674 0.587203600527445 1.0449636947804 1.50491451792822 0.400703886367374 0.561936843797093 0.390190667663858 0.405359532060357 NA NA NA 0.306167028259183 99.311357293691 a4709 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1033 Vismodegib SMO 15 30 2.30258509299405 NA 4.89835294238646 4.69048538332959 0.207867559056869 0.577261834255714 0.864097053289626 0.265699355784659 0.360092330241927 0.240560430411741 0.405435496521185 NA NA NA 0.344054680824757 99.311357293691 a4710 loss_cnaBRCA34 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 5 44 3.68887945411394 NA 3.03432548889793 3.50776919956263 -0.473443710664697 0.957503097942892 1.21489564092057 0.396137498434574 0.494456583672521 0.389699077614561 0.40550474211521 NA NA NA 0.351396805114083 99.311357293691 a4711 gain_cnaBRCA14_(RAD21) 226 GSK1070916 AURKB 21 28 0.940007258491471 2.32630161961136 2.67360805394543 2.20170245065712 0.471905603288309 1.89218790132171 1.98795017335568 0.242279218507916 0.249396797727476 0.237383013726007 0.405561054329939 NA NA NA 0.40246101107381 99.311357293691 a4712 ARID1A_mut 1058 GDC0941 PI3K (class 1) 4 39 1.38629436111989 0.693147180559945 0.791208251880241 1.40290455084444 -0.611696298964195 1.92259726337685 1.33498084020668 0.44119674993686 0.31816143225431 0.458206051009311 0.405586071378537 NA NA NA 0.574749269237046 99.311357293691 a4713 gain_cnaBRCA9_(KRAS) 1259 BMN-673 PARP1 4 42 2.30258509299405 NA 3.93005363456304 3.24606036487122 0.683993269691824 0.848350620882818 1.59643621227324 0.43933273766897 0.806262473150595 0.42845010933312 0.405674977585044 NA NA NA 0.218618959116212 99.311357293691 a4714 gain_cnaBRCA14_(RAD21) 197 Bryostatin 1 PRKC 21 27 -4.8283137373023 NA -2.67409601988887 -2.91002118113633 0.235925161247464 1.04737036471659 0.899136797604513 0.244131883576969 0.225254761061818 0.262390730616318 0.405772473120109 NA NA NA 0.415456306765763 99.311357293691 a4715 gain_cnaBRCA64_(SDHC) 1001 AICAR AAPK1 (AMPK) agonist 9 36 7.60090245954208 NA 8.08402096314772 7.65209887883772 0.43192208430999 1.58114420218514 1.33064641713207 0.312829224062788 0.273170583500907 0.324595684284717 0.405882634270479 NA NA NA 0.46589100258574 99.311357293691 a4716 gain_cnaBRCA19 1133 JNJ-26854165 MDM2 3 40 2.30258509299405 NA 3.37664164881104 2.93822884075037 0.438412808060666 0.986157157711685 0.866052534856989 0.502596924694669 0.444566877228753 0.506219646517242 0.405997854243456 NA NA NA 0.524820011039026 99.311357293691 a4717 loss_cnaBRCA36_(FAT1,IRF2) 1025 SB 216763 GSK3A, GSK3B 8 31 2.30258509299405 NA 4.68073747845598 4.94294813448011 -0.262210656024132 0.883354944402151 0.762342695561434 0.333318930239038 0.296834989927626 0.343953785549193 0.406010082399475 NA NA NA 0.459950575386785 99.311357293691 a4718 loss_cnaBRCA17 1239 YK 4-279 RNA helicase A 9 33 2.30258509299405 NA 2.33474383207744 1.92595534780535 0.408788484272087 1.1223164479155 1.33408705839464 0.315786898828448 0.364236383625437 0.306418146926633 0.406042330375929 NA NA NA 0.368103484128494 99.311357293691 a4719 gain_cnaBRCA14_(RAD21) 310 YM201636 FYV1 21 28 1.63315443905142 NA 2.27402110997948 2.52015226416441 -0.246131154184937 1.02928392725275 1.0077696907736 0.242021551679692 0.239128531659756 0.244233535140353 0.406056950841135 NA NA NA 0.407912174323074 99.311357293691 a4720 ARID1A_mut 1170 CCT018159 HSP90 5 38 2.30258509299405 NA 2.92250891342409 3.39813360720833 -0.475624693784244 0.953486476439991 1.21410678338553 0.399284257191191 0.498826890088753 0.391748650360033 0.406160180740172 NA NA NA 0.351214300291308 99.311357293691 a4721 loss_cnaBRCA22_(SYNCRIP,ZNF292) 205 BMS-708163 g-secretase 18 30 2.32630161961136 0.940007258491471 4.79046001099774 4.96017122159275 -0.169711210595008 0.778764398841825 0.613021479466498 0.249941479104321 0.217923688919783 0.276843824041377 0.406181010963827 NA NA NA 0.436157077944593 99.311357293691 a4722 gain_cnaBRCA63 37 Crizotinib MET, ALK 3 11 0.693147180559945 NA 2.99645022677041 2.55843127921474 0.438018947555666 0.609594995608457 0.811152484187725 0.560714901215509 0.718540917676768 0.539995815946112 0.406184692707452 NA NA NA 0.361962970294613 99.311357293691 a4723 loss_cnaBRCA24 1241 CHIR-99021 GSK3B 3 43 2.30258509299405 NA 4.68914117094744 4.19955773817575 0.489583432771691 1.0823423370459 0.972365520074952 0.500784532654715 0.452336951086972 0.503497319335174 0.406213823571214 NA NA NA 0.518246030303889 99.311357293691 a4724 gain_cnaBRCA62 309 Y-39983 ROCK 10 39 2.99573227355399 NA 4.67882967466511 5.00066073560776 -0.321831060942658 1.48630393661062 0.963532158997844 0.297071721421313 0.216531123288662 0.334011748271474 0.406216901452095 NA NA NA 0.528658566240864 99.311357293691 a4725 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1219 PFI-1 BRD2, BRD3, BRD4 6 41 2.30258509299405 NA 3.49140061213677 3.12580990882237 0.365590703314401 1.05462723385677 0.990583870722665 0.366359034384711 0.346653956561919 0.369065875308155 0.406372384584668 NA NA NA 0.453026699685061 99.311357293691 a4726 loss_cnaBRCA18 1069 EHT 1864 Rac GTPases 15 31 2.30258509299405 NA 3.71400500513955 3.48759105770291 0.226413947436631 0.701825040985332 0.922886186472949 0.263657217815872 0.322607393886596 0.245332469761988 0.406406412685011 NA NA NA 0.362767905949981 99.311357293691 a4727 MLL3_mut 1052 RO-3306 CDK1 3 40 1.6094379124341 NA 4.08659306640694 3.48360438272086 0.602988683686084 1.17874172153004 1.20233254262732 0.501991707124576 0.511552847135495 0.501515730721588 0.406558603955116 NA NA NA 0.47232935284055 99.311357293691 a4728 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1030 KU-55933 ATM 5 37 2.30258509299405 NA 4.5470083683975 4.17841975864929 0.368588609748207 0.744179624718854 0.939966907327624 0.399657829118739 0.495295218392277 0.392129347187471 0.406576015124726 NA NA NA 0.354661574576579 99.311357293691 a4729 BRCA2_mut 272 AR-42 HDAC 6 43 1.63315443905142 NA 0.631679481722573 0.0736368722040971 0.558042609518476 1.65631885201548 1.51431399171755 0.364722412784937 0.336917380877133 0.368511822891856 0.406883309105783 NA NA NA 0.463470880806942 99.311357293691 a4730 gain_cnaBRCA30_(CRNKL1,FOXA2) 260 NG-25 MAP3K7 (TAK1) 5 44 2.32630161961136 NA 3.66410788300072 3.1565519866838 0.507555896316918 1.80860044360925 1.22522544324345 0.394915947065683 0.280634618945485 0.414255106369079 0.406943674683983 NA NA NA 0.570727011892318 99.311357293691 a4731 ARID1A_mut 266 Zibotentan, ZD4054 Endothelin A Receptor 5 44 2.99573227355399 NA 5.56745326141739 5.76187871667181 -0.194425455254422 0.36395720458836 0.502745160686587 0.39480571821136 0.534198671721086 0.386727651418661 0.407073673792127 NA NA NA 0.321148265050955 99.311357293691 a4732 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 170 Shikonin unknown 5 42 2.77258872223978 NA -0.416094838939045 0.0535726316404203 -0.469667470579465 0.990701293940373 1.20408219850448 0.39578617066025 0.474075761737859 0.390062631241299 0.407234528896635 NA NA NA 0.369197247386459 99.311357293691 a4733 loss_cnaBRCA57 1067 CCT007093 PPM1D 4 42 1.88706964903238 NA 4.47933503189771 4.04814109933564 0.431193932562069 0.475659027257418 1.0129527685328 0.437463976859169 0.906518972315676 0.425680195520495 0.407659462136393 NA NA NA 0.179970611715146 99.311357293691 a4734 loss_cnaBRCA18 293 MP470 PDGFR 15 33 2.99573227355399 NA 3.83028314240321 3.39581337232057 0.434469770082646 1.24550803332093 1.82447721188103 0.260214676035813 0.348829359955398 0.238133843083032 0.407682909704851 NA NA NA 0.342413552936214 99.311357293691 a4735 loss_cnaBRCA38 308 XL-880 MET 4 45 1.63315443905142 NA 1.20548291190869 1.90481776396559 -0.699334852056901 1.46841399244218 1.61323293393642 0.435891089829255 0.476251830652886 0.433498992827073 0.40769601119137 NA NA NA 0.420750944991379 99.311357293691 a4736 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1527 GDC0941 (rescreen) PI3K 6 39 1.38629436111989 NA 0.613300695678551 1.03717201762286 -0.423871321944304 1.15084999086098 1.15683931913009 0.366624872031163 0.368311530877449 0.366404663927782 0.407758001268621 NA NA NA 0.430419631348822 99.311357293691 a4737 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 16 27 1.6094379124341 NA 2.83301624373716 2.4099044518749 0.423111791862266 1.3971402391325 1.71114124836732 0.263882147914334 0.302841318295277 0.247268770048046 0.407774489379541 NA NA NA 0.383829428887123 99.311357293691 a4738 gain_cnaBRCA31 202 GSK-1904529A IGF1R 16 32 0.0237165266173161 NA 2.33169748853836 2.11866289308479 0.213034595453576 1.0345592342502 0.715159642656904 0.255780472679315 0.20591821947051 0.297883972677942 0.407824381459368 NA NA NA 0.466983748001799 99.311357293691 a4739 gain_cnaBRCA58_(CCND1) 254 AC220 FLT3 10 38 0.0237165266173161 NA 2.43132446542958 2.16914016872041 0.262184296709163 0.894127747734112 0.880631050471452 0.296827666204561 0.293229124555845 0.297723202661093 0.407938164676686 NA NA NA 0.421801402641102 99.311357293691 a4740 loss_cnaBRCA7_(FAS,PTEN) 231 FMK RSK 4 45 2.99573227355399 2.32630161961136 5.35180308139105 5.61033428545429 -0.258531204063241 0.411733747358506 0.603830298376748 0.435656052797845 0.627908704889648 0.428152089681884 0.407947049213465 NA NA NA 0.310529114871749 99.311357293691 a4741 loss_cnaBRCA33 1114 Cetuximab EGFR 5 40 4.18661983833127 NA 5.97344151265826 6.32122799794243 -0.347786485284169 1.5662603527187 0.773224637102797 0.396220651811333 0.222048961834782 0.449787123425468 0.408162524454094 NA NA NA 0.648947839625473 99.311357293691 a4742 gain_cnaBRCA8_(CHD4,WNK1) 1028 VX-702 p38 3 42 0.693147180559945 NA 3.10824208046217 3.44958781404361 -0.34134573358144 0.359434864623152 0.695768693305559 0.499186961846331 0.949673410060881 0.490602317790019 0.408166378895882 NA NA NA 0.234621114269669 99.311357293691 a4743 gain_cnaBRCA13_(FGFR1,WHSC1L1) 163 JQ1 BRD4 10 37 0.940007258491471 NA 0.657504764755218 0.223595658051621 0.433909106703598 1.75529384051356 1.37405237353317 0.29754528963765 0.247200267378962 0.315787895033335 0.408216302024219 NA NA NA 0.482747791393423 99.311357293691 a4744 gain_cnaBRCA64_(SDHC) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 7 35 -1.38629436111989 0.693147180559945 -0.791269426908858 -0.204431574336842 -0.586837852572015 2.59668562808713 1.48108059485151 0.346039339837241 0.225994955347874 0.396222767762918 0.408252228084432 NA NA NA 0.581010107680747 99.311357293691 a4745 gain_cnaBRCA12_(TERT) 260 NG-25 MAP3K7 (TAK1) 9 40 2.32630161961136 NA 2.88542221855819 3.28100067155168 -0.395578452993484 1.79184368508489 1.15421305556427 0.307775428473525 0.22076616185119 0.342725678839333 0.408370081858393 NA NA NA 0.541353653794611 99.311357293691 a4746 loss_cnaBRCA24 268 YM155 BIRC5 (Survivin) 3 46 1.63315443905142 NA -4.34138655709002 -3.54693831359986 -0.794448243490159 1.07653444991189 1.61764664886497 0.497040625630093 0.737968249464917 0.491113584074486 0.408427680801852 NA NA NA 0.329206752749364 99.311357293691 a4747 loss_cnaBRCA60 302 PI-103 PI3Ka, PRKDC (DNAPK) 3 45 2.32630161961136 NA 0.263764649756564 1.18607772671462 -0.922313076958053 0.264311099069856 1.89490541168845 0.497452313048181 3.48949809600803 0.486733042857389 0.408450065599161 NA NA NA 0.00807780817831684 99.311357293691 a4748 loss_cnaBRCA29_(MAP2K4) 277 ABT-869 VEGFR and PDGFR family 7 41 0.0237165266173161 NA 2.55253290124409 2.71473233150432 -0.162199430260236 0.549658731192472 0.463307439693915 0.341141493260398 0.295091155758315 0.350090277780545 0.408495955978302 NA NA NA 0.483285438372023 99.311357293691 a4749 ARID1A_mut 1021 Axitinib PDGFR, KIT, VEGFR 5 40 0.693147180559945 NA 2.87407170629901 2.41088687991336 0.46318482638565 1.22748085841776 1.16444481685898 0.395731634662334 0.377345865077441 0.397773101549854 0.408736701199292 NA NA NA 0.460417179332431 99.311357293691 a4750 gain_cnaBRCA47_(EGFR) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 7 41 0.246860077931526 2.32630161961136 -0.746505951852123 -0.18273532103603 -0.563770630816093 1.46966595564694 1.67930824104045 0.34096177087889 0.383604606645409 0.335715991286267 0.408741061986511 NA NA NA 0.382917845703167 99.311357293691 a4751 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 265 Tubastatin A HDAC6 6 43 2.99573227355399 NA 4.36178240156361 4.73780280844518 -0.376020406881573 0.810052123290769 1.05871272432458 0.363268674650808 0.464192853854912 0.355167552294662 0.408742212317518 NA NA NA 0.33824571968642 99.311357293691 a4752 gain_cnaBRCA64_(SDHC) 1017 Olaparib PARP1, PARP2 9 36 1.6094379124341 NA 4.29533327957174 4.0187893023793 0.276543977192438 1.15578758378223 0.816502988458503 0.310905458884247 0.239268859670104 0.338693159855462 0.408752664632898 NA NA NA 0.513741502792429 99.311357293691 a4753 gain_cnaBRCA16 41 S-Trityl-L-cysteine KIF11 3 9 1.63315443905142 NA 0.520007307263404 1.4588586943884 -0.938851387125 0.878131696614211 1.77330204013602 0.574578138444921 1.06914645120419 0.529436816670547 0.408952281235145 NA NA NA 0.264092947845504 99.311357293691 a4754 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 206 Ruxolitinib JAK1, JAK2, TYK2 15 34 1.65632149833295 0.0237165266173161 4.4873508895033 4.31860290651956 0.168747982983747 0.428276687864255 0.72825965232498 0.2582352549368 0.394016269774722 0.231714035570989 0.408996232062318 NA NA NA 0.31740568408926 99.311357293691 a4755 loss_cnaBRCA7_(FAS,PTEN) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 38 -1.38629436111989 0.693147180559945 0.370653484426718 -0.373068553364693 0.743722037791412 1.0422844010455 1.73818075869839 0.438535349319352 0.713550003286428 0.427873818111034 0.409088895528202 NA NA NA 0.265110549777363 99.311357293691 a4756 gain_cnaBRCA48 185 OSI-906 IGF1R 5 43 0.940007258491471 NA 2.49579614625869 2.93973337379877 -0.443937227540072 1.73067038507151 1.05274451943708 0.393566082604585 0.256511714402352 0.421695121032265 0.409179797251098 NA NA NA 0.602052890954369 99.311357293691 a4757 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 341 EX-527 SIRT1 6 43 2.99573227355399 NA 5.85021234048864 5.61266592227641 0.237546418212233 0.471948099061156 0.673059053581553 0.362883600139799 0.503331655927384 0.352935477129645 0.409235482188718 NA NA NA 0.307618878823025 99.311357293691 a4758 loss_cnaBRCA22_(SYNCRIP,ZNF292) 151 QS11 ARFGAP 18 30 2.32630161961136 NA 3.99025102965432 3.62256921061635 0.367681819037961 1.45496437601391 1.49591333719805 0.248280677789227 0.25270846839926 0.245790855589706 0.409283740819872 NA NA NA 0.407071938710031 99.311357293691 a4759 gain_cnaBRCA62 328 SNX-2112 HSP90 9 39 0.940007258491471 NA -0.092874812780247 0.534958749730079 -0.627833562510326 2.53793442676895 1.91883731219034 0.307754411489685 0.247379741528477 0.327194785363881 0.409585555837001 NA NA NA 0.50102755423321 99.311357293691 a4760 loss_cnaBRCA28_(GPS2) 1091 BMS-536924 IGF1R 4 43 1.38629436111989 NA 3.45836559093915 2.98283120786939 0.475534383069755 0.685236628606655 1.11811095988685 0.434440039841611 0.693971050608744 0.425301602551035 0.410314085664531 NA NA NA 0.27301269350209 99.311357293691 a4761 PIK3CA_mut 1192 GSK269962A ROCK1, ROCK2 16 30 1.6094379124341 NA 2.42229192615088 2.79895788449047 -0.376665958339585 1.49053146452799 1.44980851696773 0.257317370410054 0.252705808165455 0.259803935437889 0.410343088730287 NA NA NA 0.416400143655028 99.311357293691 a4762 gain_cnaBRCA14_(RAD21) 275 I-BET BRD2, BRD3, BRD4 21 28 2.99573227355399 NA 3.85267167191685 4.17864309989298 -0.325971427976134 1.50858259523298 1.23741255752308 0.239785084581641 0.216077945620069 0.263429869039497 0.410376857368879 NA NA NA 0.42453384810185 99.311357293691 a4763 gain_cnaBRCA9_(KRAS) 304 SB52334 ALK5 4 45 2.99573227355399 NA 4.80868668771731 4.25684330871879 0.551843378998523 1.1970675502564 1.27856516814607 0.433321660667567 0.460996022221405 0.431611460054634 0.410445521046578 NA NA NA 0.433859755634232 99.311357293691 a4764 gain_cnaBRCA19 158 PF-562271 FAK 3 42 0.940007258491471 NA 1.73562539133157 2.37593769228388 -0.640312300952314 0.526456754140045 1.3149707945918 0.496737345867019 1.21626761536805 0.486940321097459 0.410452250066336 NA NA NA 0.15221359357187 99.311357293691 a4765 gain_cnaBRCA63 158 PF-562271 FAK 6 39 0.940007258491471 NA 2.74040319804039 2.27061128363271 0.469791914407683 1.729652555923 1.2192667757782 0.364451282399304 0.271610568723142 0.385306910464969 0.410521394880786 NA NA NA 0.545892728831153 99.311357293691 a4766 POLR2B_mut 226 GSK1070916 AURKB 3 46 0.940007258491471 2.32630161961136 3.30876528311571 2.34493786743274 0.963827415682974 0.769492678152383 1.98428199732591 0.49475709166965 1.25254917044462 0.485731068961902 0.410568639556466 NA NA NA 0.142880686503839 99.311357293691 a4767 BRCA1_mut 257 NPK76-II-72-1 PLK3 4 45 2.32630161961136 NA 4.10949211707109 3.42291302417934 0.686579092891751 0.88161776445845 1.62179467846923 0.433197207188578 0.77877184486351 0.423345261892089 0.410578985092107 NA NA NA 0.229787738310542 99.311357293691 a4768 loss_cnaBRCA38 1259 BMN-673 PARP1 3 43 2.30258509299405 NA 4.02754751357411 3.25516528656096 0.772382227013149 1.58851180813742 1.55564230013904 0.496022555434371 0.486230082179113 0.496503744430268 0.41065687288444 NA NA NA 0.491387500847292 99.311357293691 a4769 TP53_mut 203 BMS-345541 IKBKB 38 11 2.77258872223978 NA 3.59666702116686 3.31008439291749 0.286582628249366 1.00387067710825 1.02462294000136 0.284217421485148 0.285477636496859 0.279695697862265 0.410667844931107 NA NA NA 0.423927003067695 99.311357293691 a4770 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 273 CUDC-101 HDAC, EGFR 15 34 1.63315443905142 NA -0.306685630478539 0.0968972765805138 -0.403582907059052 1.37314700142924 1.64484738499881 0.257248641612604 0.293910926243865 0.245361916698032 0.410775518260586 NA NA NA 0.379722358747935 99.311357293691 a4771 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1072 BMS-708163 g-secretase 5 41 1.6094379124341 NA 4.0190678204953 3.64341829920647 0.37564952128883 0.807076261493922 0.968603581962125 0.393330170060231 0.465444889425309 0.387825864248682 0.410830171432668 NA NA NA 0.377311194494333 99.311357293691 a4772 PIK3CA_mut 1023 GW 441756 NTRK1 16 29 0.693147180559945 NA 2.57621660233461 2.23960137768649 0.336615224648119 1.0043022181563 1.43610026331052 0.258568392260455 0.335173236265553 0.234395350553136 0.410962858668005 NA NA NA 0.363535896302136 99.311357293691 a4773 loss_cnaBRCA22_(SYNCRIP,ZNF292) 140 Vinorelbine Microtubules 17 30 -2.74887219562247 NA -3.86456388333092 -3.44979394742095 -0.414769935909971 1.58481001367657 1.67953022823036 0.251913692275699 0.261715872773768 0.246955921922878 0.411016895754809 NA NA NA 0.40465116399773 99.311357293691 a4774 loss_cnaBRCA36_(FAT1,IRF2) 71 Pyrimethamine Dihydrofolate reductase (DHFR) 3 11 2.99573227355399 NA 4.13198211243855 4.68889485989119 -0.556912747452636 1.40249602750117 0.903419777207163 0.554706097612775 0.397086862659345 0.616449585788657 0.411087834208199 NA NA NA 0.56992372110271 99.311357293691 a4775 TP53_mut 228 KIN001-102 AKT1 38 11 2.32630161961136 NA 1.85401912898756 2.25352266377256 -0.399503534784997 1.36420145860605 1.55487939388658 0.283952657303615 0.292847901799791 0.256935384413577 0.411100766819439 NA NA NA 0.453098627078027 99.311357293691 a4776 loss_cnaBRCA29_(MAP2K4) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 38 1.6094379124341 NA 2.00756948863467 2.64099559624325 -0.633426107608575 2.9683088265293 1.37732985982257 0.395000750302626 0.213396295542876 0.459894267949852 0.411172204198916 NA NA NA 0.661209536809431 99.311357293691 a4777 gain_cnaBRCA47_(EGFR) 1001 AICAR AAPK1 (AMPK) agonist 7 38 7.60090245954208 NA 7.340622893054 7.8117733698713 -0.471150476817304 1.02214798024622 1.43068832725501 0.341176667283175 0.46094155241965 0.329317341759038 0.411405581422927 NA NA NA 0.318503050194193 99.311357293691 a4778 gain_cnaBRCA58_(CCND1) 341 EX-527 SIRT1 10 39 2.99573227355399 NA 5.79480149030396 5.60251009737892 0.192291392925045 0.471262512707299 0.690995659683593 0.293730041106992 0.4080345619268 0.278281621932467 0.411478665013339 NA NA NA 0.312450041856511 99.311357293691 a4779 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1133 JNJ-26854165 MDM2 5 38 2.30258509299405 NA 3.27315959788884 2.92877054176326 0.344389056125578 0.825188095215594 0.877426025127132 0.394730027445462 0.417346127655418 0.392499249239477 0.411490244469247 NA NA NA 0.421831497935976 99.311357293691 a4780 NF1_mut 1067 CCT007093 PPM1D 5 41 1.88706964903238 NA 4.43045332620387 4.0435853577724 0.386867968431466 0.724203508828281 1.00824012633482 0.392438161878907 0.534197865262205 0.383706181024374 0.411883954046833 NA NA NA 0.323472634398589 99.311357293691 a4781 CDH1_mut 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 4 45 1.63315443905142 NA 3.17991458671607 3.611922881436 -0.432008294719929 0.519433307141574 1.02472315061086 0.431953318652225 0.831691554585241 0.42158537597438 0.411914394090121 NA NA NA 0.206998156698447 99.311357293691 a4782 MLL3_mut 260 NG-25 MAP3K7 (TAK1) 3 46 2.32630161961136 NA 2.61312581597052 3.24716194306912 -0.634036127098593 1.35311260066641 1.28233644265152 0.493249200340698 0.468576027439497 0.494438203586869 0.411986149135355 NA NA NA 0.505057796822822 99.311357293691 a4783 gain_cnaBRCA47_(EGFR) 293 MP470 PDGFR 7 41 2.99573227355399 NA 4.0144894685884 3.44913810103678 0.565351367551615 1.7897746195335 1.65115721506013 0.33855596743833 0.315878525363698 0.342397054862535 0.412030805194517 NA NA NA 0.457761593294612 99.311357293691 a4784 gain_cnaBRCA64_(SDHC) 1007 Docetaxel Microtubules 9 36 -4.38202663467388 NA -4.20641971343782 -4.68249464104948 0.476074927611659 2.0555375658539 1.40067879439971 0.308400112367151 0.231606045795563 0.339888723606821 0.412509040777235 NA NA NA 0.525680699401253 99.311357293691 a4785 loss_cnaBRCA22_(SYNCRIP,ZNF292) 294 MPS-1-IN-1 MPS1 19 30 2.99573227355399 NA 4.9304766672299 4.64634369224624 0.284132974983659 1.31714915547891 1.07311267303814 0.242312363071847 0.215718146879385 0.264774596482246 0.412726571126281 NA NA NA 0.435809369997004 99.311357293691 a4786 loss_cnaBRCA38 301 PHA-793887 CDK-pan 4 44 2.32630161961136 NA 2.2725363325607 2.98133659465441 -0.708800262093708 1.83731806726598 1.62754826281995 0.431656774149773 0.3857798356865 0.4355018393529 0.412753565901179 NA NA NA 0.503665392693805 99.311357293691 a4787 MACF1_mut 1170 CCT018159 HSP90 3 40 2.30258509299405 NA 2.79387716787524 3.38399975343529 -0.590122585560047 0.214145536927557 1.2206828765136 0.495286584827812 2.755708076044 0.483436441121792 0.412803090069403 NA NA NA 0.0190304072058591 99.311357293691 a4788 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 275 I-BET BRD2, BRD3, BRD4 15 34 2.99573227355399 NA 3.79737586252344 4.14551394027664 -0.348138077753205 1.30988991569167 1.38006159372581 0.256070833509449 0.265776592050009 0.252262710110874 0.41290581324883 NA NA NA 0.406125868008012 99.311357293691 a4789 loss_cnaBRCA17 94 TGX221 PI3Kbeta 4 10 2.30258509299405 NA 3.31097982334512 3.95244387721878 -0.641464053873659 1.28655940168283 1.27620142063711 0.501614533307606 0.498588757763242 0.502635433169653 0.413095624927528 NA NA NA 0.433229628470145 99.311357293691 a4790 PTEN_mut 1072 BMS-708163 g-secretase 8 38 1.6094379124341 NA 3.43064546217104 3.73764014927825 -0.306994687107215 0.723348423254439 0.992901883270736 0.321419822510221 0.424407764277699 0.309189349199277 0.413099996848426 NA NA NA 0.327929748750048 99.311357293691 a4791 ARID1A_mut 196 Phenformin AAPK1 (AMPK) agonist 5 43 8.29404964010203 NA 7.83531245955521 7.12837362178245 0.706938837772761 1.0932861776568 1.86600291425371 0.390155913377319 0.646618289172846 0.378851947321579 0.413220746951226 NA NA NA 0.251094317128301 99.311357293691 a4792 NF1_mut 1009 ATRA Retinoic acid and retinoid X receptor agonist 4 41 2.30258509299405 NA 4.5624587714372 4.06143546672227 0.501023304714932 1.03578144872851 1.1662269485826 0.432810921903246 0.48371527152757 0.429610467605694 0.413220919455722 NA NA NA 0.415805726715433 99.311357293691 a4793 gain_cnaBRCA58_(CCND1) 328 SNX-2112 HSP90 10 38 0.940007258491471 NA -0.0566502436027822 0.541947904223123 -0.598598147825905 2.00925910187814 2.04776799091309 0.293388637329572 0.297919838843268 0.292317367241879 0.41335136402554 NA NA NA 0.417482364982517 99.311357293691 a4794 gain_cnaBRCA8_(CHD4,WNK1) 1264 SGC0946 Q8TEK3 (DOT1L) 3 43 -0.693147180559945 NA 1.67091204146261 1.97023470670659 -0.299322665243981 0.490064266588183 0.612098063939882 0.493050253422019 0.610782474159682 0.489010965526235 0.413445185014825 NA NA NA 0.403524155545256 99.311357293691 a4795 loss_cnaBRCA18 344 THZ-2-49 CDK9 16 33 2.99573227355399 NA 1.53572632637847 1.90626828943431 -0.370541963055836 1.90811701831947 1.21862432099874 0.251361526553637 0.194192473259414 0.304065786863792 0.413471217482422 NA NA NA 0.485615539051115 99.311357293691 a4796 gain_cnaBRCA62 1031 Elesclomol HSP70 8 36 -1.6094379124341 NA -2.50603136030663 -3.08236745062944 0.57633609032281 1.86518702171325 1.76932958597156 0.322757442659788 0.308996408195796 0.325736988118206 0.41361454327979 NA NA NA 0.443499658706036 99.311357293691 a4797 PTEN_mut 272 AR-42 HDAC 9 40 1.63315443905142 NA 0.521882330673424 0.0564880354762698 0.465394295197154 1.61007401596847 1.51351867543608 0.304102974278574 0.289051491162172 0.307491610609339 0.413945051880536 NA NA NA 0.44452839556617 99.311357293691 a4798 loss_cnaBRCA57 201 Epothilone B Microtubules 5 43 -3.44201937618241 NA -3.60608797869825 -4.30897536036316 0.702887381664916 0.956092865049358 1.8657644147097 0.389420994330722 0.735166433470486 0.376728903243811 0.414094791573741 NA NA NA 0.207563200388579 99.311357293691 a4799 gain_cnaBRCA62 200 LAQ824 HDAC 9 39 0.0237165266173161 NA -2.33521742429839 -2.76506356040497 0.429846136106582 1.81994136243538 1.30885624228122 0.304617567685627 0.236186805233866 0.32841355851075 0.414340299389861 NA NA NA 0.518210682275229 99.311357293691 a4800 MACF1_mut 1502 Bicalutamide ANDR (androgen receptor) 3 42 2.30258509299405 NA 4.28998523914963 4.57746869679176 -0.287483457642131 0.320950302560201 0.593492922473806 0.492565242097499 0.895725772335757 0.484392394173528 0.41436354932953 NA NA NA 0.256065992440448 99.311357293691 a4801 gain_cnaBRCA16 1373 Dabrafenib BRAF 16 30 2.30258509299405 NA 4.48667917736094 4.06947444042783 0.417204736933111 1.15375507465826 1.83571853925156 0.255093706282825 0.361605982150664 0.227270536311742 0.414368769065891 NA NA NA 0.350734540089965 99.311357293691 a4802 loss_cnaBRCA22_(SYNCRIP,ZNF292) 177 GSK-650394 SGK3 18 29 2.77258872223978 NA 4.27306849104477 3.85391004445419 0.41915844659058 1.85531915543195 1.59209949246078 0.247095015990373 0.225922556430994 0.263274028146771 0.41458103980823 NA NA NA 0.433001370872036 99.311357293691 a4803 BRCA2_mut 304 SB52334 ALK5 6 43 2.99573227355399 NA 4.7027137095726 4.24596310199486 0.456750607577733 1.13502901441277 1.28920204784902 0.358604776681794 0.402413155767689 0.354289390355687 0.414741100786948 NA NA NA 0.394624214462389 99.311357293691 a4804 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 127 GSK269962A ROCK1, ROCK2 4 10 0.916290731874155 NA 2.86324244896532 2.31000777010421 0.553234678861118 0.910461551369676 1.16521012904209 0.499745634652749 0.60764200094869 0.474793914910374 0.414789194267839 NA NA NA 0.375505648629397 99.311357293691 a4805 gain_cnaBRCA64_(SDHC) 1042 BIRB 0796 p38, JNK2 7 36 2.30258509299405 NA 4.103319257431 4.41778816794878 -0.314468910517775 0.559166630611804 0.972971202403621 0.340311271226508 0.562388549856244 0.323204746184587 0.414797812822938 NA NA NA 0.257077486722527 99.311357293691 a4806 gain_cnaBRCA47_(EGFR) 1017 Olaparib PARP1, PARP2 7 38 1.6094379124341 NA 4.32846760280558 4.0272405574253 0.301227045380274 0.50752320734991 0.937063422279224 0.33858447273355 0.593523687228344 0.321458546154323 0.414940531357696 NA NA NA 0.237440956694315 99.311357293691 a4807 loss_cnaBRCA18 205 BMS-708163 g-secretase 15 33 2.32630161961136 0.940007258491471 4.77692804818278 4.9508938219091 -0.173965773726315 0.714612171241574 0.663104856383628 0.256135381643651 0.243440821087703 0.262350323710599 0.415019062693667 NA NA NA 0.431521456844817 99.311357293691 a4808 gain_cnaBRCA63 1039 SL 0101-1 RSK, AURKB, PIM3 5 38 2.30258509299405 NA 4.31514265233244 4.69273437321153 -0.377591720879088 1.82731219115964 0.818516260375011 0.391466728281767 0.206637772519573 0.461312424882177 0.415335806683682 NA NA NA 0.670859088904658 99.311357293691 a4809 loss_cnaBRCA17 1268 XAV 939 TNKS1 (tankyrase-1) 9 38 1.6094379124341 NA 3.89293375299191 3.60661585405662 0.286317898935298 0.57641947005771 1.00085532110727 0.304749150225436 0.496717952477616 0.286073214476733 0.415374020527596 NA NA NA 0.267752907446672 99.311357293691 a4810 loss_cnaBRCA22_(SYNCRIP,ZNF292) 110 Roscovitine CDKs 3 10 2.77258872223978 NA 3.64136245765391 4.2116224192429 -0.570259961588993 0.418799685535582 1.11420251118124 0.557148737380776 1.36165327072707 0.511809976971261 0.415379658758848 NA NA NA 0.212385145615989 99.311357293691 a4811 gain_cnaBRCA27_(CLTC,PPM1D) 1529 MLN4924 NEDD8-activating enzyme 7 30 0 NA -0.107554911119412 0.480461648492529 -0.588016559611941 1.95424289054961 1.64235609335409 0.345914213552587 0.300892259839086 0.358032318320852 0.415466438723319 NA NA NA 0.481575324836139 99.311357293691 a4812 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1133 JNJ-26854165 MDM2 6 37 2.30258509299405 NA 3.24061446618111 2.92474031836112 0.315874147819991 0.684368810292247 0.895611281818415 0.361995126477941 0.46155544067694 0.352691121954886 0.415540795059422 NA NA NA 0.346240386898325 99.311357293691 a4813 loss_cnaBRCA36_(FAT1,IRF2) 193 GW-2580 CSF1R (cFMS) 9 39 2.99573227355399 NA 5.64753804203633 5.42089290417978 0.226645137856542 0.312723723420535 0.808110303533797 0.303824307903047 0.724745584944832 0.280463121018804 0.415548023222372 NA NA NA 0.181425060901797 99.311357293691 a4814 loss_cnaBRCA42 290 KIN001-260 IKK 3 46 2.99573227355399 NA 4.565292949038 5.07529846235768 -0.510005513319681 0.37224363800775 1.06221848579149 0.489352365001348 1.37008523785452 0.480132402270954 0.415663262272673 NA NA NA 0.117846757221995 99.311357293691 a4815 loss_cnaBRCA24 265 Tubastatin A HDAC6 3 46 2.99573227355399 NA 4.21623118349659 4.72277220917467 -0.506541025678079 0.703423695087039 1.04764081972798 0.489256926311063 0.720107993540652 0.483506385146012 0.415753569980105 NA NA NA 0.338855866547956 99.311357293691 a4816 loss_cnaBRCA33 87 GW843682X PLK1 4 8 -1.36257783450257 NA -1.2450790329871 -2.24951384473375 1.00443481174665 1.93749862528011 1.92987944520929 0.519848495443819 0.518418335187946 0.520465055078984 0.415790917218668 NA NA NA 0.428746240451378 99.311357293691 a4817 gain_cnaBRCA64_(SDHC) 281 CH5424802 ALK 8 40 1.63315443905142 NA 3.8575276206912 3.51878202711854 0.33874559357266 0.884109077935103 1.09462861849958 0.317987332760668 0.383149095543531 0.309461663844476 0.41585849332589 NA NA NA 0.362178787248983 99.311357293691 a4818 gain_cnaBRCA61_(NOTCH2) 204 Tipifarnib Farnesyl-transferase (FNTA) 3 45 2.77258872223978 NA 2.31506972495756 1.57363698100424 0.741432743953314 2.42663545883181 1.45954321779894 0.489560366599724 0.305539400759536 0.507989578459643 0.415870935087356 NA NA NA 0.651029614663757 99.311357293691 a4819 loss_cnaBRCA28_(GPS2) 1021 Axitinib PDGFR, KIT, VEGFR 3 42 0.693147180559945 NA 2.99880545487831 2.42403374674748 0.574771708130826 0.573267142804671 1.19224527888591 0.490949484427623 1.00262454484796 0.48209182985226 0.415884414385797 NA NA NA 0.215548836137613 99.311357293691 a4820 loss_cnaBRCA60 1194 SB-505124 TGFR1 (ALK5) 3 44 2.30258509299405 NA 3.9677620908959 4.41771979367794 -0.449957702782041 1.3313672823693 0.894491051650744 0.489972961216091 0.337966621788464 0.503032089534784 0.415903167885805 NA NA NA 0.619446683034326 99.311357293691 a4821 loss_cnaBRCA28_(GPS2) 155 AP-24534 ABL 4 43 -0.669430653942629 NA 1.89072155494543 1.40393075681804 0.486790798127396 1.14933878739183 1.13405969112277 0.428858568695137 0.423539867850505 0.429246186896433 0.416308857853122 NA NA NA 0.467930526817009 99.311357293691 a4822 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1061 SB590885 BRAF 16 26 1.6094379124341 NA 4.18772328206899 3.90371995139684 0.284003330672152 1.01373934320349 1.13061986515591 0.260969693706678 0.280154196023094 0.251192588618623 0.416332833525348 NA NA NA 0.404806205852365 99.311357293691 a4823 gain_cnaBRCA14_(RAD21) 269 NSC-207895 MDM4 21 28 2.99573227355399 NA 4.44320874166293 4.72449264286903 -0.2812839012061 1.38902964449999 1.01429693357748 0.236713063829704 0.202503886306439 0.277319088616384 0.416356445835979 NA NA NA 0.438123465733729 99.311357293691 a4824 gain_cnaBRCA16 37 Crizotinib MET, ALK 3 11 0.693147180559945 NA 2.31535869553017 2.74418351500754 -0.428824819477368 0.99942716014057 0.731024792660374 0.548242574895549 0.429070608224269 0.586607764583157 0.41640613155185 NA NA NA 0.544112717930168 99.311357293691 a4825 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1054 PD-0332991 CDK4, CDK6 8 34 1.38629436111989 0.693147180559945 3.26584882677538 2.79280024691345 0.473048579861934 1.08163890177317 1.53523685971743 0.32267457398713 0.437344273663277 0.308127424682209 0.416426003294917 NA NA NA 0.324947298281499 99.311357293691 a4826 gain_cnaBRCA63 1047 Nutlin-3a MDM2 5 38 2.07944154167984 1.38629436111989 3.85993913905654 4.25260317713779 -0.392664038081247 1.65988285391982 0.906865685493778 0.390527491090119 0.236561295367302 0.432990292126277 0.416446697737715 NA NA NA 0.629305805419374 99.311357293691 a4827 ASH1L_mut 1008 Methotrexate Dihydrofolate reductase (DHFR) 3 42 -1.6094379124341 NA 0.183994312140084 0.718268343184846 -0.534274031044762 0.896451812819831 1.0985149541731 0.490183212608706 0.595987451198496 0.486360271214454 0.416606874666795 NA NA NA 0.413273978563095 99.311357293691 a4828 loss_cnaBRCA36_(FAT1,IRF2) 88 MS-275 HDAC 3 11 1.6094379124341 NA 1.90415746146132 0.930540030162472 0.973617431298847 2.26320211319174 1.66377592271486 0.547661647008754 0.430194645729532 0.585185431527434 0.416886365423029 NA NA NA 0.543252278023315 99.311357293691 a4829 NF1_mut 238 CAL-101 PI3Kdelta 5 44 2.99573227355399 2.32630161961136 4.39070815845653 4.75626604454287 -0.365557886086339 1.16912798075514 0.922238094338937 0.386521869669005 0.312675679740575 0.396381247240033 0.416916292134591 NA NA NA 0.531813507807431 99.311357293691 a4830 loss_cnaBRCA24 309 Y-39983 ROCK 3 46 2.99573227355399 NA 5.43126281970977 4.90261471687445 0.52864810283532 0.877901560749879 1.09195799158373 0.487812867802268 0.602172414847701 0.484128608343799 0.417121451788266 NA NA NA 0.408877941473226 99.311357293691 a4831 loss_cnaBRCA57 1114 Cetuximab EGFR 5 40 4.18661983833127 NA 5.97926990838202 6.32049944847696 -0.341229540094936 1.09587641019271 0.852540127217025 0.38863280654129 0.311375933381878 0.400250415436541 0.417127693899663 NA NA NA 0.534065438387304 99.311357293691 a4832 MLL3_mut 1069 EHT 1864 Rac GTPases 3 43 2.30258509299405 NA 3.16864472720918 3.58882473684316 -0.420180009633981 1.60510794062896 0.806487616755046 0.489122205868197 0.261776793322283 0.520999952019849 0.417147818014359 NA NA NA 0.695769518230783 99.311357293691 a4833 gain_cnaBRCA15 1069 EHT 1864 Rac GTPases 22 24 2.30258509299405 NA 3.45306811987844 3.66074580118991 -0.207677681311472 0.844687219368892 0.871956959395307 0.241752771716114 0.245863411389886 0.23817423448916 0.417173165663714 NA NA NA 0.416534506015545 99.311357293691 a4834 BRCA1_mut 238 CAL-101 PI3Kdelta 4 45 2.99573227355399 2.32630161961136 5.08989820121544 4.68599230994016 0.403905891275272 0.588729909044546 0.965316939412482 0.427065531770705 0.68606314214743 0.418417904819012 0.417187505959979 NA NA NA 0.277094420862843 99.311357293691 a4835 loss_cnaBRCA29_(MAP2K4) 1373 Dabrafenib BRAF 7 39 2.30258509299405 NA 3.74838320037435 4.29826711917922 -0.54988391880487 3.5716530652831 1.04093586513469 0.33618736260342 0.153957819741735 0.528259172560758 0.4172005393463 NA NA NA 0.69962963279756 99.311357293691 a4836 loss_cnaBRCA17 56 WH-4-023 SRC family, ABL 3 9 1.63315443905142 NA 3.69839072096338 3.06491550405266 0.633475216910715 0.643008634356056 1.21362752778583 0.564119547058065 0.98517373339024 0.521968398382033 0.417241420988914 NA NA NA 0.286088757031083 99.311357293691 a4837 TP53_mut 178 BAY 61-3606 SYK 38 10 2.07944154167984 NA 3.19314522479973 2.72566168973073 0.467483535069003 1.52899912148312 1.89449195460369 0.290893162913936 0.305744802924115 0.246759313985472 0.417306736877695 NA NA NA 0.484446115808045 99.311357293691 a4838 CDH1_mut 1039 SL 0101-1 RSK, AURKB, PIM3 4 39 2.30258509299405 NA 5.02512705653021 4.61023362096358 0.414893435566629 0.876955213642046 0.971210117843048 0.430108187203366 0.473106755182574 0.427192250105531 0.417392032373853 NA NA NA 0.425405622678809 99.311357293691 a4839 loss_cnaBRCA34 1042 BIRB 0796 p38, JNK2 5 38 2.30258509299405 NA 4.68485859267212 4.32471883907401 0.360139753598107 0.588964464875959 0.95335099741061 0.389699348953326 0.611479596946406 0.37776197284765 0.417427696708102 NA NA NA 0.276149366918146 99.311357293691 a4840 gain_cnaBRCA12_(TERT) 133 Doxorubicin DNA intercalating 9 39 0.0237165266173161 NA -0.579477813212449 -1.13476048437736 0.555282671164916 1.6782055098699 1.86722561260159 0.302482538980472 0.330878827354084 0.297383812334946 0.417595724594582 NA NA NA 0.397223896571346 99.311357293691 a4841 gain_cnaBRCA19 329 QL-XI-92 DDR1 4 44 2.32630161961136 NA 3.88253857806074 4.2870438727501 -0.404505294689363 1.92584800277425 0.83700604751234 0.42715241378384 0.210040093562243 0.483276430190189 0.417611340230223 NA NA NA 0.704165375197732 99.311357293691 a4842 gain_cnaBRCA19 140 Vinorelbine Microtubules 4 43 -2.74887219562247 NA -4.24411545051544 -3.53988238691145 -0.704233063603992 1.62264442390031 1.64853961177613 0.427630540122707 0.434003317813304 0.427186012743276 0.41763495723427 NA NA NA 0.458439028512488 99.311357293691 a4843 BRCA1_mut 1164 XMD8-92 MAP2K5 (ERK5) 3 23 2.30258509299405 NA 4.46775113150968 3.80841131569056 0.659339815819127 0.685257435595391 1.34501092782589 0.506073030883828 0.962178272821301 0.49021149358608 0.417816809806519 NA NA NA 0.239280055779819 99.311357293691 a4844 NF1_mut 1371 PLX4720 (rescreen) BRAF 5 42 2.30258509299405 NA 5.03783722902265 4.66777950029674 0.370057728725908 0.498155749756323 0.990172977448453 0.386790436180709 0.742855480252762 0.373730385653928 0.417898418873097 NA NA NA 0.205959743004185 99.311357293691 a4845 POLR2B_mut 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 3 43 0 NA 1.59345295130023 0.587617158964779 1.00583579233545 1.37297668967592 2.08746570769647 0.488181857874095 0.732594952193159 0.481845420802335 0.418037194544813 NA NA NA 0.332494947672293 99.311357293691 a4846 loss_cnaBRCA57 196 Phenformin AAPK1 (AMPK) agonist 5 43 8.29404964010203 NA 7.82883883075371 7.12912636931751 0.699712461436197 1.21867402344345 1.85888197739624 0.386109515550658 0.574158838192933 0.376415754170844 0.418047151789621 NA NA NA 0.29545917121218 99.311357293691 a4847 loss_cnaBRCA36_(FAT1,IRF2) 229 LY317615 PRKCB (PKCbeta) 9 40 2.99573227355399 2.32630161961136 3.75580698333568 3.26920769195638 0.486599291379295 1.04052290365633 1.70850914732359 0.301403073729388 0.467648803951758 0.284809298294692 0.418073139635915 NA NA NA 0.282037803946691 99.311357293691 a4848 gain_cnaBRCA63 1028 VX-702 p38 6 39 0.693147180559945 NA 3.63938897763241 3.39413027090829 0.245258706724114 1.16278978336185 0.592925426106151 0.358548485777413 0.210922653633079 0.413641743000924 0.41808381977048 NA NA NA 0.632405589615516 99.311357293691 a4849 gain_cnaBRCA14_(RAD21) 273 CUDC-101 HDAC, EGFR 21 28 1.63315443905142 NA -0.237954860086218 0.131831250298927 -0.369786110385145 1.81649333661776 1.35730021863041 0.235650779643818 0.203571410327148 0.272442386223351 0.418436436186274 NA NA NA 0.438682711322961 99.311357293691 a4850 loss_cnaBRCA34 231 FMK RSK 5 44 2.99573227355399 2.32630161961136 5.38390060286717 5.61256254901526 -0.228661946148089 0.349437264617981 0.611399608958001 0.385197424877871 0.654371955429745 0.37399753417866 0.418503287339475 NA NA NA 0.246931620171952 99.311357293691 a4851 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1003 Camptothecin TOP1 7 38 -2.30258509299405 NA -2.07843884573642 -2.61233139634652 0.533892550610102 1.44832528053897 1.61073812918229 0.335977423549305 0.368627516058702 0.331458317734824 0.418514420980417 NA NA NA 0.401733622573722 99.311357293691 a4852 loss_cnaBRCA36_(FAT1,IRF2) 172 Embelin XIAP 9 39 3.46573590279973 NA 2.75560703637382 3.04785952058648 -0.292252484212659 0.824309387432607 0.995797850005709 0.301864384395646 0.354542224883437 0.293485755377945 0.418541166041398 NA NA NA 0.373224437042449 99.311357293691 a4853 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 207 AS601245 JNK 15 33 2.07944154167984 NA 2.04191394150917 2.36814924571473 -0.32623530420556 1.49813925945221 1.17803654758167 0.254090130615494 0.217760333124737 0.276931394764681 0.418727360596416 NA NA NA 0.463997975686905 99.311357293691 a4854 CDH1_mut 203 BMS-345541 IKBKB 4 45 2.77258872223978 NA 3.13811238043166 3.56737390232681 -0.429261521895153 0.637158119822644 1.02902554321957 0.425613135099445 0.673712707317676 0.417153417350649 0.418762284393986 NA NA NA 0.284140577248148 99.311357293691 a4855 loss_cnaBRCA23 1494 SN-38 TOP1 3 45 -2.99573227355399 NA -2.53613982976749 -3.35496508860066 0.818825258833177 1.0217433921593 1.70817715790486 0.486192086205749 0.801400102135936 0.479356169261446 0.419063041832329 NA NA NA 0.29769103419024 99.311357293691 a4856 gain_cnaBRCA48 1010 Gefitinib EGFR 5 40 -0.693147180559945 NA 1.04143983190839 1.44470506252498 -0.403265230616593 1.19482964818484 1.0251455051371 0.386975020620332 0.337508557164801 0.393373651443425 0.419102281872063 NA NA NA 0.504038575812957 99.311357293691 a4857 loss_cnaBRCA7_(FAS,PTEN) 1373 Dabrafenib BRAF 4 42 2.30258509299405 NA 4.85192320838952 4.15389064802505 0.698032560364473 0.50237680201633 1.68908175863898 0.426735121810491 1.38946017722726 0.413261558710414 0.419168093451476 NA NA NA 0.0779475693921987 99.311357293691 a4858 loss_cnaBRCA29_(MAP2K4) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 6 41 2.32630161961136 NA 0.94025921814829 1.48669389431108 -0.54643467616279 1.00726248884753 1.58683549708574 0.356379258945755 0.542494813628964 0.344354961283844 0.419180529893551 NA NA NA 0.284017169299934 99.311357293691 a4859 gain_cnaBRCA19 1011 ABT-263 BCL2, BCL2L1, BCL2L2 3 40 0.693147180559945 NA 0.922291623420953 1.73892117651611 -0.816629553095154 1.07433489321854 1.69681871835566 0.488461676640038 0.760125691020476 0.481270947957556 0.419219293611718 NA NA NA 0.318595969154571 99.311357293691 a4860 gain_cnaBRCA16 91 KIN001-135 IKKE 3 11 1.6094379124341 NA 3.87685362676474 3.65614328750262 0.220710339262121 0.557765777676984 0.367178659500286 0.544672351011848 0.395704340594987 0.601097949326625 0.419363344274144 NA NA NA 0.571540964855261 99.311357293691 a4861 loss_cnaBRCA60 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 3 43 0 NA 1.59073072349054 0.587807081835222 1.00292364165532 0.823169468593997 2.10128570805661 0.486747072718352 1.21836836753476 0.477290469263641 0.41939643117552 NA NA NA 0.15180201516191 99.311357293691 a4862 loss_cnaBRCA29_(MAP2K4) 256 JW-7-24-1 LCK 7 41 2.32630161961136 NA 1.50623431512804 1.8941384870441 -0.387904171916062 0.437358136060278 1.23700576391877 0.333171346193372 0.886925702149507 0.31358315638498 0.419452385719176 NA NA NA 0.139066987442474 99.311357293691 a4863 gain_cnaBRCA14_(RAD21) 157 JNK-9L JNK 21 26 1.63315443905142 NA -0.0838215914510169 0.168651362242078 -0.252472953693095 0.927858778739015 1.14855601809354 0.239044126665979 0.272102780593629 0.21981770999047 0.419505365279147 NA NA NA 0.408918180687647 99.311357293691 a4864 BRCA2_mut 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 6 43 3.68887945411394 NA 3.08708763485736 3.51141735851398 -0.424329723656619 1.31010375219146 1.18130774067645 0.354888931388588 0.323890167436606 0.359203371861118 0.419558812698413 NA NA NA 0.479739352137273 99.311357293691 a4865 loss_cnaBRCA42 266 Zibotentan, ZD4054 Endothelin A Receptor 3 46 2.99573227355399 NA 5.51764974894901 5.75667349116955 -0.239023742220548 0.24547720418405 0.500810982444474 0.485180627347789 0.973710544793952 0.477273363802577 0.419621872119067 NA NA NA 0.225501945633269 99.311357293691 a4866 loss_cnaBRCA18 1494 SN-38 TOP1 16 32 -2.99573227355399 NA -3.02383214341306 -3.44376669317885 0.419934549765792 1.67079129864794 1.69063556824451 0.249339132992991 0.251338722020888 0.248388569159133 0.419647099370506 NA NA NA 0.419930697690197 99.311357293691 a4867 gain_cnaBRCA58_(CCND1) 329 QL-XI-92 DDR1 10 38 2.32630161961136 NA 4.47030516715388 4.19623771162391 0.274067455529963 0.77489758732518 0.984373716945882 0.289393092089861 0.353682163956657 0.278418095497597 0.419695428509227 NA NA NA 0.361492819552702 99.311357293691 a4868 loss_cnaBRCA20 1024 CEP-701 FLT3, JAK2, NTRK1, RET 3 42 0.693147180559945 NA 1.27826046632178 0.5789480977867 0.699312368535082 0.953143061666733 1.45580134952511 0.486875163577379 0.733690876700309 0.480362495036292 0.419734572318194 NA NA NA 0.33206417822464 99.311357293691 a4869 loss_cnaBRCA57 207 AS601245 JNK 5 43 2.07944154167984 NA 2.70859818240044 2.21475914695864 0.493839035441794 0.684904320268816 1.32700300845149 0.384616045613762 0.721033611304961 0.372146131015984 0.419837141909174 NA NA NA 0.214974227938972 99.311357293691 a4870 gain_cnaBRCA63 1377 Afatinib (rescreen) ERBB2, EGFR 6 41 2.30258509299405 NA 2.21719617541775 2.92499778189318 -0.707801606475427 3.06906492654346 1.80912094412756 0.355870919836116 0.230624513790456 0.391240623670278 0.419839443714426 NA NA NA 0.603151866403334 99.311357293691 a4871 loss_cnaBRCA23 1199 Tamoxifen ER 3 44 1.6094379124341 NA 4.3027386303837 3.83960873992354 0.463129890460165 0.891281685326938 0.956300569361368 0.485713126496758 0.519622357425959 0.484293228821824 0.419938530529769 NA NA NA 0.466240580014503 99.311357293691 a4872 gain_cnaBRCA16 193 GW-2580 CSF1R (cFMS) 16 32 2.99573227355399 NA 5.58731323645214 5.40142668306576 0.185886553386388 1.01006128236545 0.576465110757028 0.249151926336601 0.184034926030491 0.322459330005727 0.419993791519369 NA NA NA 0.502650779142352 99.311357293691 a4873 loss_cnaBRCA60 298 OSI-930 KIT, VEGFR, PDGFR 3 45 2.32630161961136 NA 4.31086521694878 3.88686743507512 0.423997781873652 0.764835412203523 0.878885645119517 0.484992150384306 0.554364736658959 0.482426563942792 0.420203803717419 NA NA NA 0.441232319509378 99.311357293691 a4874 ASH1L_mut 305 TPCA-1 IKK 3 46 2.99573227355399 NA 3.55025968506319 4.21928723613217 -0.66902755106898 1.49981156088401 1.37607526482239 0.484252906345393 0.446074405957137 0.486185289549066 0.420505296983761 NA NA NA 0.523383608141621 99.311357293691 a4875 loss_cnaBRCA38 1010 Gefitinib EGFR 3 42 -0.693147180559945 NA 0.92716304516019 1.43366458393002 -0.506501538769828 0.730648331121346 1.05499083440085 0.486017884400335 0.693222056625362 0.48010041628227 0.420547438981335 NA NA NA 0.354199455414944 99.311357293691 a4876 gain_cnaBRCA10_(MDM2,NUP107) 346 THZ-2-102-1 CDK7 5 43 0.916290731874155 2.99573227355399 -0.459645133745977 -1.43696141832215 0.977316284576172 3.27886241638333 2.4644993053099 0.383912223611113 0.298065658288333 0.396557743989008 0.420682314448061 NA NA NA 0.549712663016919 99.311357293691 a4877 gain_cnaBRCA14_(RAD21) 274 PXD101, Belinostat HDAC 21 27 2.99573227355399 NA 0.472553963825532 0.826241754297239 -0.353687790471707 1.65538337922019 1.36148774776053 0.236362612981244 0.213659140783642 0.259780369712087 0.420768197082335 NA NA NA 0.432898542702411 99.311357293691 a4878 loss_cnaBRCA24 152 CP466722 ATM 3 46 2.77258872223978 NA 2.24800786774973 2.76158527543338 -0.513577407683648 0.5704469065732 1.07845565135898 0.483685125593279 0.900307113187483 0.476215602409314 0.421046523456609 NA NA NA 0.253908505701184 99.311357293691 a4879 gain_cnaBRCA62 60 BI-2536 PLK1, PLK2, PLK3 4 8 -1.36257783450257 NA -2.03749997826415 -1.22803392332609 -0.809466054938053 1.03022802847168 1.75830399808579 0.513746988498073 0.785715426650617 0.460367522236937 0.421102038197158 NA NA NA 0.340936233509328 99.311357293691 a4880 loss_cnaBRCA17 194 AUY922 HSP90 10 37 -1.36257783450257 NA -2.78743624868794 -2.28734459538721 -0.500091653300731 1.03647522295024 1.86156479990286 0.289346224989856 0.48249262715346 0.268640475650821 0.421157959600139 NA NA NA 0.274772978589935 99.311357293691 a4881 gain_cnaBRCA14_(RAD21) 309 Y-39983 ROCK 21 28 2.99573227355399 NA 4.78997980693777 5.04373176748788 -0.253751960550116 1.29963533380288 0.890932273449132 0.234120455096098 0.19524858546867 0.284816217923892 0.421443941673517 NA NA NA 0.447064342260239 99.311357293691 a4882 loss_cnaBRCA22_(SYNCRIP,ZNF292) 266 Zibotentan, ZD4054 Endothelin A Receptor 19 30 2.99573227355399 NA 5.81376183019413 5.6966151688986 0.117146661295527 0.621448062842895 0.392021635149257 0.237776130876325 0.188505956168926 0.298827030939057 0.421467659738819 NA NA NA 0.469039434602109 99.311357293691 a4883 POLR2B_mut 200 LAQ824 HDAC 3 45 0.0237165266173161 NA -3.32436453611689 -2.64180760146953 -0.682556934647362 0.669818949814964 1.43605338270958 0.483597517117862 1.01901705652836 0.475300530513356 0.421532026727628 NA NA NA 0.2096679540427 99.311357293691 a4884 gain_cnaBRCA14_(RAD21) 253 XMD14-99 EPHB3, CAMK1 21 27 2.32630161961136 NA 5.0357605402893 4.85325618461583 0.182504355673466 0.751028387347143 0.790275865045631 0.23595943426866 0.243005935259153 0.230937529217 0.421555455217072 NA NA NA 0.41873499315974 99.311357293691 a4885 loss_cnaBRCA34 344 THZ-2-49 CDK9 5 44 2.99573227355399 NA 1.27875703100941 1.84283385496229 -0.56407682395287 1.04915854468404 1.50798716996698 0.382552846145157 0.537646885507419 0.374059431795578 0.421683073150472 NA NA NA 0.320406834126894 99.311357293691 a4886 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 91 KIN001-135 IKKE 3 11 1.6094379124341 NA 3.87600368846507 3.65637508885707 0.219628599607994 0.235671592791156 0.431329061032177 0.54184846053738 0.931926487222504 0.509190359403142 0.421712221787396 NA NA NA 0.285679869182169 99.311357293691 a4887 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 173 FH535 unknown 6 42 3.46573590279973 NA 1.17674108761464 1.62960621056621 -0.452865122951573 1.26464909883089 1.28270437663146 0.353592540540772 0.358095477528293 0.353054944850859 0.422007058660994 NA NA NA 0.441501615579283 99.311357293691 a4888 gain_cnaBRCA48 293 MP470 PDGFR 5 43 2.99573227355399 NA 4.10428248475318 3.46499246508979 0.639290019663392 2.24582799420841 1.60488886586679 0.382713479827482 0.284656715167861 0.398339120707971 0.422124178337277 NA NA NA 0.56632194198209 99.311357293691 a4889 gain_cnaBRCA62 1049 PD-173074 FGFR1, FGFR3 7 36 0.693147180559945 NA 3.25837698707114 2.87542257378245 0.382954413288685 1.14574602012181 1.14292730734786 0.334943528833076 0.334240230001384 0.33506454069885 0.422136929279975 NA NA NA 0.440337257490959 99.311357293691 a4890 TP53_mut 1091 BMS-536924 IGF1R 37 10 1.38629436111989 NA 3.09056289451548 2.77443772050677 0.31612517400871 1.07615227110447 1.16737931332577 0.288697240772706 0.293755059109121 0.270799019992991 0.422192862366792 NA NA NA 0.453347576858675 99.311357293691 a4891 loss_cnaBRCA42 200 LAQ824 HDAC 3 45 0.0237165266173161 NA -3.32341791465606 -2.64187070956692 -0.681547205089148 0.292118157453695 1.44182249473008 0.482871908498034 2.33312167593411 0.472698413001759 0.42222408783774 NA NA NA 0.0277705054541886 99.311357293691 a4892 PTEN_mut 1527 GDC0941 (rescreen) PI3K 8 37 1.38629436111989 NA 0.680415198602577 1.04557273709573 -0.365157538493154 1.07072304426705 1.17270892986085 0.31568374265851 0.341038273574394 0.311379515577222 0.422605100548996 NA NA NA 0.408446009834077 99.311357293691 a4893 gain_cnaBRCA13_(FGFR1,WHSC1L1) 173 FH535 unknown 10 38 3.46573590279973 NA 1.86456716887257 1.49626936001956 0.368297808853007 2.02813223763633 1.01925009248232 0.287557775140611 0.181594573577823 0.361341943031902 0.422629226343526 NA NA NA 0.590122903419282 99.311357293691 a4894 gain_cnaBRCA14_(RAD21) 62 BMS-536924 IGF1R 6 6 1.63315443905142 NA 2.91158989706093 3.41748603171189 -0.505896134650958 0.859438941872015 1.20795395486274 0.482595707780147 0.588635341038915 0.418804154425275 0.422745061553225 NA NA NA 0.424788207712095 99.311357293691 a4895 ARID1A_mut 223 ZSTK474 PI3K 5 44 1.63315443905142 2.32630161961136 0.416138620513435 0.968724250061974 -0.552585629548539 1.58202212756539 1.43532933824849 0.381516533112627 0.349290708341057 0.384988737304604 0.422933092174637 NA NA NA 0.490216922578276 99.311357293691 a4896 gain_cnaBRCA62 1149 TW 37 BCL2, BCL2L1 7 36 1.6094379124341 NA 0.206853199519819 -0.210291522663312 0.417144722183131 1.06252578274438 1.27677117531893 0.334326071348876 0.392597270539352 0.326718467840512 0.422986189981631 NA NA NA 0.380939371879739 99.311357293691 a4897 CDH1_mut 158 PF-562271 FAK 4 41 0.940007258491471 NA 1.83564486221181 2.3817970683188 -0.54615220610699 0.944660771329151 1.31180375686167 0.4235099051252 0.578146380883951 0.416336821151964 0.423254368492856 NA NA NA 0.345629836228323 99.311357293691 a4898 loss_cnaBRCA28_(GPS2) 268 YM155 BIRC5 (Survivin) 4 45 1.63315443905142 NA -2.9767900770315 -3.65058137308306 0.673791296051552 1.92355790934379 1.57453125489511 0.421359923710415 0.350283863448338 0.427931356685858 0.423394602840282 NA NA NA 0.540012462367896 99.311357293691 a4899 ARID1A_mut 1248 FK866 NAMPT 5 39 0 NA -1.5746905718346 -0.532246293254764 -1.04244427857984 3.74625535587044 2.58309383643319 0.383897569653426 0.278263006536997 0.403564231340227 0.423542952922395 NA NA NA 0.574933601321507 99.311357293691 a4900 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1199 Tamoxifen ER 18 29 1.6094379124341 NA 3.72658336544727 3.95767240930124 -0.23108904385398 1.2307886153439 0.736054391790305 0.24232994234906 0.187756890966536 0.313956477172702 0.423572476261541 NA NA NA 0.477930233429981 99.311357293691 a4901 CDH1_mut 305 TPCA-1 IKK 4 45 2.99573227355399 NA 3.64392926963803 4.22582832974927 -0.581899060111238 1.76015425836929 1.35203888556198 0.421148655541426 0.330595490335229 0.430386334539016 0.423625506556525 NA NA NA 0.561006989522985 99.311357293691 a4902 loss_cnaBRCA17 89 Parthenolide NFKB1 4 10 1.6094379124341 NA 3.74302562615866 3.05260164516708 0.690423980991576 0.220424044218122 1.62192274200573 0.490029579986427 3.1322534864135 0.425682409593549 0.423668242184737 NA NA NA 0.218133775204718 99.311357293691 a4903 gain_cnaBRCA58_(CCND1) 273 CUDC-101 HDAC, EGFR 10 39 1.63315443905142 NA -0.383954268794416 0.0649683496026553 -0.448922618397072 1.46383894928919 1.59345322058833 0.286035935367631 0.306674869264177 0.281729399141898 0.423751400408193 NA NA NA 0.409082032402602 99.311357293691 a4904 gain_cnaBRCA8_(CHD4,WNK1) 293 MP470 PDGFR 4 44 2.99573227355399 NA 2.88617691761304 3.59025865345852 -0.70408173584548 2.55438401687327 1.5906070621188 0.421480086300023 0.275636604048017 0.442649698101802 0.423777979936186 NA NA NA 0.623264912100619 99.311357293691 a4905 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 8 38 1.38629436111989 NA 3.2431477280064 2.77765377364535 0.465493954361043 0.880528483107161 1.57021434914941 0.314073685571116 0.528652920707839 0.296452490459792 0.42377871399287 NA NA NA 0.262311739434792 99.311357293691 a4906 loss_cnaBRCA20 293 MP470 PDGFR 3 45 2.99573227355399 NA 2.77830227662475 3.5818040353945 -0.803501758769756 1.54839923145328 1.6758496253704 0.480991740830018 0.518924152407138 0.479459342058905 0.424020525757679 NA NA NA 0.466745495037446 99.311357293691 a4907 gain_cnaBRCA14_(RAD21) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 21 26 0.940007258491471 NA 2.05284717075636 1.7560449383765 0.296802232379862 1.09242886235457 1.3696185120334 0.236682442369596 0.271690214903467 0.216704308369209 0.424081024358008 NA NA NA 0.412915493253149 99.311357293691 a4908 loss_cnaBRCA20 152 CP466722 ATM 3 46 2.77258872223978 NA 2.25118913088508 2.76137780175064 -0.510188670865557 1.24736075646929 1.05289831606116 0.480449333977437 0.40901452784972 0.484556450592634 0.424139028255166 NA NA NA 0.554730643801586 99.311357293691 a4909 gain_cnaBRCA15 1175 AG-014699 PARP1, PARP2 21 22 1.6094379124341 NA 3.99097664743411 3.73804674053008 0.252929906904028 1.04638762828176 1.00830631663349 0.246266196344468 0.241717218426364 0.250846298125458 0.424198436912816 NA NA NA 0.424637380428499 99.311357293691 a4910 loss_cnaBRCA22_(SYNCRIP,ZNF292) 257 NPK76-II-72-1 PLK3 19 30 2.32630161961136 NA 3.7084141126381 3.33363954720769 0.374774565430409 1.66954195139696 1.53113029094838 0.23636623739261 0.224477477260648 0.244769872065083 0.424207127751514 NA NA NA 0.434500571034767 99.311357293691 a4911 gain_cnaBRCA16 154 CHIR-99021 GSK3B 16 31 0.940007258491471 NA 3.42385143616742 3.1988357873021 0.225015648865322 0.926017849213461 0.896563172785954 0.248228009457618 0.242992777144032 0.250975788093231 0.424261885656128 NA NA NA 0.431275491840019 99.311357293691 a4912 MACF1_mut 1066 AZD6482 PI3Kbeta 3 40 1.6094379124341 NA 1.32046410546646 2.01569190291802 -0.695227797451552 0.307854725021148 1.47409631725531 0.48303182298136 2.25829828469839 0.471629831316605 0.424367177506445 NA NA NA 0.0340292167066106 99.311357293691 a4913 loss_cnaBRCA24 305 TPCA-1 IKK 3 46 2.99573227355399 NA 4.80121923662205 4.13770291755224 0.663516319069814 1.2714478909769 1.38642332795045 0.480208434256173 0.521858838084201 0.478581329160617 0.424369807576868 NA NA NA 0.464512012061367 99.311357293691 a4914 loss_cnaBRCA24 260 NG-25 MAP3K7 (TAK1) 3 46 2.32630161961136 NA 2.6286791708857 3.24614759383552 -0.617468422949816 0.857580065030111 1.30168044734038 0.480179834208888 0.720012565740011 0.474362524390251 0.424397211143028 NA NA NA 0.339067153028756 99.311357293691 a4915 gain_cnaBRCA58_(CCND1) 1262 UNC1215 LMBL3 9 37 0 NA 2.90077921815619 2.72267354836481 0.178105669791389 0.300169698621942 0.641639512412396 0.299674499470801 0.59334993041956 0.277579024274485 0.424410437933154 NA NA NA 0.230780763473089 99.311357293691 a4916 gain_cnaBRCA61_(NOTCH2) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 3 45 2.07944154167984 NA 3.73758565146396 3.17941797077309 0.558167680690875 0.817988527093538 1.17494667345761 0.480470867473604 0.682366148427712 0.475057884157678 0.424519018586531 NA NA NA 0.360137994250446 99.311357293691 a4917 CDH1_mut 1114 Cetuximab EGFR 4 41 4.18661983833127 NA 6.62024635229911 6.2496424895559 0.3706038627432 0.489659545620888 0.900660718610816 0.42197993727965 0.756860283961737 0.41147998917375 0.424918849878673 NA NA NA 0.243653593853949 99.311357293691 a4918 PTEN_mut 268 YM155 BIRC5 (Survivin) 9 40 1.63315443905142 NA -3.20795701914206 -3.68279272311463 0.474835703972562 1.54174154400027 1.61068754161189 0.296927833387478 0.307986579086746 0.294803114635985 0.424970552561981 NA NA NA 0.423560453615942 99.311357293691 a4919 gain_cnaBRCA64_(SDHC) 208 SB-715992 KIF11 8 41 -2.05572501506252 NA -1.68471191638669 -1.15310657472418 -0.531605341662506 2.48230443511977 1.53409925743729 0.311063061312178 0.214157995345505 0.346526040662161 0.424988338897084 NA NA NA 0.574945815266945 99.311357293691 a4920 ASH1L_mut 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 3 42 2.30258509299405 NA 1.86081971225711 1.32993146555035 0.53088824670676 0.916853950150254 1.11122437635017 0.481337576177052 0.579032512887967 0.477750720741448 0.425002124872395 NA NA NA 0.424706173347729 99.311357293691 a4921 gain_cnaBRCA10_(MDM2,NUP107) 1241 CHIR-99021 GSK3B 3 43 2.30258509299405 NA 4.67117246909717 4.20081136853739 0.470361100559776 0.90118125338534 0.981752551405622 0.480826679390714 0.521938398954524 0.479103517364266 0.425033454532587 NA NA NA 0.464720839784907 99.311357293691 a4922 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 257 NPK76-II-72-1 PLK3 7 42 2.32630161961136 NA 3.92530162185267 3.40457007627109 0.520731545581582 1.85332364908989 1.542544312869 0.328410116134827 0.280971726572042 0.337579634657669 0.42519499992505 NA NA NA 0.502919303153016 99.311357293691 a4923 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 272 AR-42 HDAC 7 42 1.63315443905142 NA 0.572900263522849 0.0701466797726588 0.50275358375019 2.85730655235687 1.22142494563483 0.328403244373741 0.175953673341592 0.411612343064506 0.425204621492632 NA NA NA 0.661754853807457 99.311357293691 a4924 TP53_mut 172 Embelin XIAP 38 10 3.46573590279973 NA 2.93537896335041 3.21225840229215 -0.276879438941746 0.909607695822734 1.17952767545263 0.285927177325702 0.304394345181205 0.234737551906526 0.425246157507856 NA NA NA 0.503201872904234 99.311357293691 a4925 gain_cnaBRCA16 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 13 29 -1.38629436111989 0.693147180559945 0.0127823710975604 -0.443453859117923 0.456236230215483 1.41441310162952 1.80448591080635 0.268863681180567 0.322562220110845 0.252834465197686 0.425280472356007 NA NA NA 0.383740188607177 99.311357293691 a4926 gain_cnaBRCA8_(CHD4,WNK1) 205 BMS-708163 g-secretase 4 44 2.32630161961136 0.940007258491471 4.63498871108598 4.92030595457723 -0.285317243491244 0.910672224861001 0.660262169795934 0.419947067351897 0.313303992042574 0.432127201198619 0.425453992622899 NA NA NA 0.580135540269162 99.311357293691 a4927 gain_cnaBRCA48 1003 Camptothecin TOP1 5 40 -2.30258509299405 NA -3.06850254148509 -2.46187880684744 -0.606623734637649 0.799275734351894 1.64920773313665 0.381660209499169 0.758966785260334 0.367827364891083 0.425471017458867 NA NA NA 0.203132991885731 99.311357293691 a4928 POLR2B_mut 305 TPCA-1 IKK 3 46 2.99573227355399 NA 4.79968907943771 4.13780271041209 0.661886369025616 0.620708032816162 1.40606875737604 0.479012546646578 1.06634091075417 0.470735421403438 0.425516576158878 NA NA NA 0.194134622965726 99.311357293691 a4929 gain_cnaBRCA8_(CHD4,WNK1) 190 Bleomycin DNA damage 3 45 4.15888308335967 NA 0.844728704241957 2.16064385313525 -1.31591514889329 3.65636221640206 2.69640517529531 0.479363213834543 0.359897370941597 0.488025746631039 0.42558025478172 NA NA NA 0.598863183475521 99.311357293691 a4930 loss_cnaBRCA42 288 KIN001-055 JAK3, MNK1 3 46 2.32630161961136 NA 3.9542503363114 4.36409981484134 -0.409849478529937 0.916076847770558 0.852956384208732 0.478943153009425 0.447396394229787 0.480504614441856 0.425583176846974 NA NA NA 0.522372664865288 99.311357293691 a4931 TP53_mut 1030 KU-55933 ATM 33 9 2.30258509299405 NA 4.28215929938124 4.00281289249227 0.279346406888968 0.912655387641003 0.962750201168195 0.302685942134196 0.306080926789916 0.290154607654209 0.425631855761084 NA NA NA 0.450179244260529 99.311357293691 a4932 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1239 YK 4-279 RNA helicase A 4 38 2.30258509299405 NA 2.50928316127956 1.96137074529356 0.547912415986007 2.49744892465754 1.14388445100004 0.422959056253369 0.219388837375779 0.478992799934467 0.425790794153634 NA NA NA 0.6924339256193 99.311357293691 a4933 loss_cnaBRCA36_(FAT1,IRF2) 219 AT-7519 CDK9 9 40 2.32630161961136 NA 2.11054956918499 1.57332696355709 0.537222605627903 1.98000667037127 1.77697665971141 0.296293860692984 0.271323634241681 0.302323951579167 0.42595317589447 NA NA NA 0.469488310225841 99.311357293691 a4934 CDH1_mut 1243 piperlongumine Increases ROS levels 5 42 2.30258509299405 NA 2.00017915983985 1.67573145992117 0.324447699918682 0.960787658821935 0.842943144783249 0.379881133197898 0.33768928747118 0.384898675464179 0.426203309064378 NA NA NA 0.503771514374321 99.311357293691 a4935 gain_cnaBRCA10_(MDM2,NUP107) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 5 43 2.32630161961136 NA 5.19507664427314 4.93098037547765 0.26409626879549 0.528683191627438 0.710177153742492 0.379298436930902 0.499535965920396 0.371873788679001 0.426248205011134 NA NA NA 0.350129328406665 99.311357293691 a4936 loss_cnaBRCA57 1129 PF-4708671 RPS6KB1 (p70S6KA) 3 40 2.30258509299405 NA 4.32151787470222 3.77052560199478 0.550992272707439 0.672852225521455 1.16475733812663 0.480933478842152 0.818890466298785 0.473053274421645 0.426366779196393 NA NA NA 0.290258586193649 99.311357293691 a4937 TP53_mut 1194 SB-505124 TGFR1 (ALK5) 37 10 2.30258509299405 NA 4.44489987057465 4.18216619832549 0.262733672249162 0.907562780048319 0.961657118452972 0.286003951089539 0.289493661513062 0.27320930423915 0.426504151990971 NA NA NA 0.451186660498959 99.311357293691 a4938 gain_cnaBRCA27_(CLTC,PPM1D) 1114 Cetuximab EGFR 9 36 4.18661983833127 NA 6.49279112059251 6.23003353876822 0.262757581824285 0.581097032464582 0.933028153177937 0.299167558870281 0.452175053639257 0.281618063645048 0.426533636769317 NA NA NA 0.302901966112258 99.311357293691 a4939 gain_cnaBRCA63 155 AP-24534 ABL 6 41 -0.669430653942629 NA 1.79260017750689 1.39454409019307 0.398056087313817 1.45356303559969 1.08917875785738 0.350569582949662 0.273848520886191 0.365464423945311 0.426748505865463 NA NA NA 0.543483189372827 99.311357293691 a4940 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 150 Bicalutamide ANDR (androgen receptor) 7 41 0.0237165266173161 NA 2.93726452478511 2.73276487834717 0.204499646437937 0.925031280119929 0.564980919069978 0.327806720686153 0.221073222963254 0.361958500783648 0.426926573991835 NA NA NA 0.588892750141126 99.311357293691 a4941 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 40 1.38629436111989 NA 3.31099825579106 2.79075089219571 0.520247363595349 1.334437793167 1.50016899991499 0.350980299750691 0.389862582024639 0.346792503794459 0.427037683081031 NA NA NA 0.410127798762677 99.311357293691 a4942 gain_cnaBRCA30_(CRNKL1,FOXA2) 1010 Gefitinib EGFR 5 40 -0.693147180559945 NA 1.75230606807965 1.35584678300358 0.39645928507607 1.57302701844542 0.971689186028542 0.380345502407973 0.252035903024653 0.40801039136441 0.427055410585108 NA NA NA 0.608744255416657 99.311357293691 a4943 loss_cnaBRCA38 134 Etoposide TOP2 4 43 2.77258872223978 NA 1.64919297366248 2.55411646187103 -0.904923488208548 1.90236015176243 2.17771592756694 0.418858604569379 0.475684631729795 0.415537893052735 0.427182017125883 NA NA NA 0.422710737447494 99.311357293691 a4944 loss_cnaBRCA28_(GPS2) 1039 SL 0101-1 RSK, AURKB, PIM3 3 40 2.30258509299405 NA 5.07975256017509 4.61650904407938 0.463243516095719 0.633521850494296 0.978925940932337 0.480070124529484 0.731219476856687 0.473216100141878 0.427191158258526 NA NA NA 0.333830484491029 99.311357293691 a4945 loss_cnaBRCA18 3 Rapamycin MTOR 6 8 -2.30258509299405 NA -2.0687840485034 -3.24732319902495 1.17853915052155 0.864117714639358 3.3992941244114 0.443811325730831 1.36386412470831 0.346701140703916 0.427229069015003 NA NA NA 0.373719129528998 99.311357293691 a4946 loss_cnaBRCA60 224 AS605240 PI3Kgamma 3 46 2.99573227355399 2.32630161961136 3.97879320536006 3.22404785001715 0.754745355342905 0.742529836067161 1.6088352168464 0.477183532541073 1.016451216749 0.469125332066224 0.427274074246485 NA NA NA 0.210554523583319 99.311357293691 a4947 loss_cnaBRCA17 150 Bicalutamide ANDR (androgen receptor) 11 37 0.0237165266173161 NA 2.63037417554912 2.80189447985647 -0.171520304307352 0.606480053099745 0.628593075809626 0.274937237893049 0.282812770891152 0.272863814298995 0.427484704560875 NA NA NA 0.425498014774386 99.311357293691 a4948 gain_cnaBRCA8_(CHD4,WNK1) 271 VNLG/124 HDAC, RAR 4 45 1.63315443905142 NA 3.83955906101905 4.17916286515172 -0.339603804132662 1.40425715923313 0.756854906578839 0.417349162967515 0.241838755743371 0.448703973748086 0.427791097042546 NA NA NA 0.664098627714635 99.311357293691 a4949 gain_cnaBRCA10_(MDM2,NUP107) 1375 Temozolomide DNA akylating agent 3 43 3.40119738166216 NA 6.21220490726523 5.87835298389221 0.33385192337302 0.559136303721615 0.704470206663106 0.477941536807955 0.597085041967226 0.473904957534529 0.427797018630059 NA NA NA 0.412688551209166 99.311357293691 a4950 gain_cnaBRCA16 273 CUDC-101 HDAC, EGFR 16 33 1.63315443905142 NA -0.284172461334098 0.0982115856940899 -0.382384047028188 1.96545151059773 1.34460058534884 0.243610221004012 0.194552775770031 0.284384858369657 0.427921413373021 NA NA NA 0.489675705536191 99.311357293691 a4951 gain_cnaBRCA63 164 JQ12 HDAC 6 41 1.63315443905142 NA 2.07889933482816 1.5045637327436 0.574335602084558 1.51284765170422 1.65802508061356 0.349665629384566 0.379638757040453 0.346397415093396 0.427933401233386 NA NA NA 0.419959369753088 99.311357293691 a4952 TP53_mut 176 IPA-3 PAK1, PAK2, PAK3 37 10 3.46573590279973 NA 4.58843008379667 4.1579541049695 0.43047597882717 1.38295636157803 1.93830385535805 0.284998508660795 0.311272279290124 0.22208900716841 0.428120395126568 NA NA NA 0.523100222522765 99.311357293691 a4953 loss_cnaBRCA22_(SYNCRIP,ZNF292) 150 Bicalutamide ANDR (androgen receptor) 18 30 0.0237165266173161 NA 2.85550791297572 2.70683564173889 0.14867227123683 0.773843186572829 0.516067847997393 0.238307911899984 0.192121961938135 0.288086676613849 0.428219407383501 NA NA NA 0.475370037575439 99.311357293691 a4954 loss_cnaBRCA28_(GPS2) 1262 UNC1215 LMBL3 4 42 0 NA 2.9845780599445 2.73589576221728 0.248682297727224 0.309546101315053 0.61004557925606 0.418373496063955 0.803377256798713 0.407645438608846 0.428273087049965 NA NA NA 0.222480405108637 99.311357293691 a4955 loss_cnaBRCA18 1170 CCT018159 HSP90 14 29 2.30258509299405 NA 3.55210413643613 3.24179874934246 0.310305387093676 1.10705946817416 1.22961176894141 0.260297424866608 0.280296945208781 0.252360456309574 0.428418224270521 NA NA NA 0.41330049665947 99.311357293691 a4956 loss_cnaBRCA23 291 KIN001-266 MAP3K8 (COT) 3 46 2.99573227355399 NA 3.25105179628581 3.81304197065803 -0.561990174372226 0.202122994291382 1.20587417983303 0.475990652497177 2.78043661653882 0.466043791110977 0.428422659944084 NA NA NA 0.0166543282768469 99.311357293691 a4957 MLL3_mut 265 Tubastatin A HDAC6 3 46 2.99573227355399 NA 4.2289800904335 4.72194075872226 -0.492960668288765 0.995925668916714 1.03745317964564 0.475959411744479 0.494977369972768 0.475164256045891 0.428452765551945 NA NA NA 0.484724859103303 99.311357293691 a4958 gain_cnaBRCA62 287 KIN001-244 PDPK1 (PDK1) 10 39 2.99573227355399 NA 3.26553732423526 3.53261084124742 -0.267073517012164 1.16551424822575 0.882629381444421 0.283100316320539 0.229146505432024 0.302588518609134 0.42849163523454 NA NA NA 0.511734453662624 99.311357293691 a4959 CDH1_mut 207 AS601245 JNK 4 44 2.07944154167984 NA 2.75714929334591 2.22156902404182 0.535580269304092 0.613485281502201 1.3184489891675 0.417013716719418 0.873012418476693 0.406219940023823 0.428672074647355 NA NA NA 0.193394679570872 99.311357293691 a4960 loss_cnaBRCA7_(FAS,PTEN) 155 AP-24534 ABL 4 43 -0.669430653942629 NA 1.01173959281503 1.48569652073714 -0.473956927922116 1.34557524199757 1.11901510477354 0.41738964910262 0.35223368647784 0.423548284469343 0.428793532248933 NA NA NA 0.538389594246254 99.311357293691 a4961 gain_cnaBRCA16 1230 IOX2 EGLN1 16 31 -2.30258509299405 NA 0.355524210322718 0.194721293979767 0.160802916342952 0.542218882365318 0.703635036480803 0.245774729647769 0.29656458226147 0.228531707498819 0.428822910649968 NA NA NA 0.391015545006222 99.311357293691 a4962 NF1_mut 273 CUDC-101 HDAC, EGFR 5 44 1.63315443905142 NA -0.55748609293161 0.0336739411640328 -0.591160034095643 0.550378854599645 1.63247756887913 0.376607168138357 1.07409655940663 0.362124445300364 0.42888522340671 NA NA NA 0.110583294162445 99.311357293691 a4963 gain_cnaBRCA12_(TERT) 257 NPK76-II-72-1 PLK3 9 40 2.32630161961136 NA 3.09791034153134 3.56469653706431 -0.466786195532976 1.43290126387556 1.61536304247821 0.294355799317336 0.325762986816315 0.28896674200052 0.428965539835201 NA NA NA 0.404396575923476 99.311357293691 a4964 loss_cnaBRCA60 200 LAQ824 HDAC 3 45 0.0237165266173161 NA -3.31420590995451 -2.64248484321369 -0.671721066740818 0.2996473557365 1.44204700291336 0.47581306998498 2.24170530418933 0.465810799081959 0.428992388873298 NA NA NA 0.031986143594572 99.311357293691 a4965 PTEN_mut 1050 ZM-447439 AURKB 6 33 1.38629436111989 0.693147180559945 2.49217198765367 2.95987900772369 -0.467707020070025 1.60526135299637 1.26739093960962 0.354828914570842 0.291358799112061 0.369031374182057 0.429102703134939 NA NA NA 0.523274444774344 99.311357293691 a4966 BRCA2_mut 262 VX-11e ERK 6 43 1.63315443905142 NA 3.37065137228031 3.83348551283457 -0.462834140554258 1.28487983104129 1.33698643676836 0.347593090245305 0.360215896749792 0.346177139741955 0.429116349824365 NA NA NA 0.439513516565471 99.311357293691 a4967 gain_cnaBRCA62 134 Etoposide TOP2 9 38 2.77258872223978 NA 2.99364496922716 2.35476250084368 0.638882468383482 2.69568495315004 2.02639758584466 0.295698395527793 0.237001904705858 0.315279919817501 0.429261976646483 NA NA NA 0.519066662896063 99.311357293691 a4968 gain_cnaBRCA61_(NOTCH2) 302 PI-103 PI3Ka, PRKDC (DNAPK) 3 45 2.32630161961136 NA 0.301548577809164 1.18355879817778 -0.882010220368614 0.548421818542114 1.89336183596952 0.475407501547053 1.6082697488464 0.46584345559969 0.429383234097307 NA NA NA 0.0808586235540978 99.311357293691 a4969 gain_cnaBRCA58_(CCND1) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 9 36 2.30258509299405 NA 1.62756468745587 1.29976384729953 0.327800840156336 0.964974503999318 1.13231664292805 0.297161408352328 0.339698964892618 0.289495736200325 0.429618712653141 NA NA NA 0.394171357669437 99.311357293691 a4970 gain_cnaBRCA48 184 BMS-754807 IGF1R 5 43 0.940007258491471 NA 1.06045095326439 1.692731512984 -0.632280559719615 2.36346203774316 1.59950305479578 0.376405849363939 0.267523044424852 0.395298125767158 0.429760228670134 NA NA NA 0.588330638693754 99.311357293691 a4971 ARID1A_mut 308 XL-880 MET 5 44 1.63315443905142 NA 2.38961808389786 1.7861509228772 0.603467161020655 1.31349447349173 1.62995270398341 0.375886510943988 0.459436391396781 0.370235994913137 0.429763163961202 NA NA NA 0.382968088344163 99.311357293691 a4972 loss_cnaBRCA7_(FAS,PTEN) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 4 41 2.30258509299405 NA 1.78492389962173 1.32438744125364 0.460536458368095 1.06259806259562 1.10609331601258 0.417487480452754 0.43340607759357 0.416363114848492 0.429829105010869 NA NA NA 0.460005723866694 99.311357293691 a4973 loss_cnaBRCA20 1052 RO-3306 CDK1 3 40 1.6094379124341 NA 4.05944386051489 3.48564057316276 0.573803287352121 0.333294130816937 1.2302915979012 0.477308177896976 1.72161233666393 0.466396168462009 0.429834880015563 NA NA NA 0.0703162931042207 99.311357293691 a4974 loss_cnaBRCA36_(FAT1,IRF2) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 9 38 2.99573227355399 NA 4.1886083809877 3.76691198643138 0.421696394556323 1.5210024749538 1.40786197070425 0.295175197354493 0.277248986441743 0.299529643765702 0.430073243273721 NA NA NA 0.463530574893642 99.311357293691 a4975 gain_cnaBRCA15 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 22 26 2.77258872223978 NA -0.612501627783356 -0.287625763946604 -0.324875863836752 1.4677768557818 1.35742656854336 0.230592150030755 0.221338729083385 0.239332182944801 0.430111526719682 NA NA NA 0.433398836954314 99.311357293691 a4976 loss_cnaBRCA38 288 KIN001-055 JAK3, MNK1 4 45 2.32630161961136 NA 4.01263579795779 4.36801776221788 -0.355381964260086 0.77460447472296 0.861111137466688 0.415238259928892 0.458791519874953 0.412701623283596 0.430115995247552 NA NA NA 0.436717676875908 99.311357293691 a4977 loss_cnaBRCA34 1031 Elesclomol HSP70 4 40 -1.6094379124341 NA -2.29908726671315 -3.0454282509565 0.746340984243355 1.47586694885456 1.80834940186302 0.417731188376168 0.505696658376016 0.412719457575206 0.430173737249613 NA NA NA 0.399523335140605 99.311357293691 a4978 gain_cnaBRCA15 312 AV-951 VEGFR 22 26 -2.05572501506252 NA 0.712455674877363 0.564431379873339 0.148024295004024 0.556631216472827 0.705925510929445 0.230535028061635 0.265928842334788 0.209688264147205 0.430224993725446 NA NA NA 0.421119200562182 99.311357293691 a4979 loss_cnaBRCA60 230 GSK429286A ROCK2 3 46 2.99573227355399 2.32630161961136 5.00609012664189 5.43155228988767 -0.425462163245777 0.397650360540743 0.913560731294512 0.473963969665285 1.06994034323825 0.465718532628804 0.430378333176583 NA NA NA 0.193112579817689 99.311357293691 a4980 NF1_mut 1194 SB-505124 TGFR1 (ALK5) 5 42 2.30258509299405 NA 4.69796915142048 4.35221693898606 0.345752212434415 0.570153703086915 0.945904782602712 0.376329429935314 0.606419305114481 0.365525387748921 0.430510867595683 NA NA NA 0.277843416632444 99.311357293691 a4981 loss_cnaBRCA38 202 GSK-1904529A IGF1R 4 44 0.0237165266173161 NA 2.5069269457278 2.16083328664582 0.346093659081986 0.343057769179957 0.857274966865425 0.415246118701873 1.00884950050624 0.403713712004745 0.430618289588706 NA NA NA 0.149857221685009 99.311357293691 a4982 BRCA1_mut 228 KIN001-102 AKT1 4 45 2.32630161961136 NA 2.4798929124197 1.8960423234077 0.583850589011998 1.22101428861312 1.41960184631723 0.414736336608523 0.478168514862477 0.41127770474985 0.430669913978702 NA NA NA 0.420331433884776 99.311357293691 a4983 gain_cnaBRCA30_(CRNKL1,FOXA2) 326 GSK690693 AKT 5 43 2.32630161961136 NA 3.58936157607621 2.86402204986207 0.725339526214149 2.30563579145089 1.89166026645708 0.375593140425385 0.314594147481424 0.383440694439625 0.430750091828082 NA NA NA 0.530364587773503 99.311357293691 a4984 loss_cnaBRCA28_(GPS2) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 4 44 2.77258872223978 NA 0.0995518239577655 -0.485261658401741 0.584813482359506 1.01361679622703 1.43241845952461 0.415083644204025 0.576957174088223 0.408269998526544 0.430797447639946 NA NA NA 0.345893615665685 99.311357293691 a4985 gain_cnaBRCA31 298 OSI-930 KIT, VEGFR, PDGFR 16 32 2.32630161961136 NA 4.05522629052981 3.84243779939844 0.212788491131367 0.890827878042333 0.866515642444518 0.24332093373925 0.238865999118693 0.245567974435028 0.430879132962443 NA NA NA 0.437455076559287 99.311357293691 a4986 gain_cnaBRCA19 328 SNX-2112 HSP90 4 44 0.940007258491471 NA -0.359315714226472 0.487835926849017 -0.847151641075489 2.56374357563243 1.99985523167846 0.414988863371572 0.330435402794335 0.423606482937508 0.430901981585141 NA NA NA 0.561480525144559 99.311357293691 a4987 CDH1_mut 205 BMS-708163 g-secretase 4 44 2.32630161961136 0.940007258491471 4.63806289684771 4.92002648314434 -0.281963586296633 0.801792581399269 0.670161679422851 0.414942799965913 0.351666494350143 0.420739643811718 0.430952790482863 NA NA NA 0.538919140552005 99.311357293691 a4988 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 151 QS11 ARFGAP 9 39 2.32630161961136 NA 4.11421868065951 3.67881094170084 0.435407738958676 1.18034318633174 1.53786857499784 0.293817335480191 0.368882325073466 0.283124153804422 0.430967116051479 NA NA NA 0.363064059859162 99.311357293691 a4989 gain_cnaBRCA27_(CLTC,PPM1D) 204 Tipifarnib Farnesyl-transferase (FNTA) 9 39 2.77258872223978 NA 1.25835070512817 1.70342864035667 -0.4450779352285 1.88759339501097 1.4244324816846 0.29374462042624 0.235791212453312 0.312459832916847 0.431080398718088 NA NA NA 0.520781631852229 99.311357293691 a4990 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 263 FR-180204 ERK 7 42 2.99573227355399 NA 5.56172607528691 5.32391135838353 0.237814716903381 0.910429400919732 0.704103209764151 0.324139267632371 0.261211596048125 0.337755479034161 0.431200144268347 NA NA NA 0.530255458558534 99.311357293691 a4991 gain_cnaBRCA10_(MDM2,NUP107) 1527 GDC0941 (rescreen) PI3K 3 42 1.38629436111989 NA 1.49344173370671 0.944028277624822 0.549413456081885 2.03796594562048 1.09610480590301 0.474843965434966 0.269589125010924 0.50124171805748 0.431229743115429 NA NA NA 0.687739079176173 99.311357293691 a4992 loss_cnaBRCA20 151 QS11 ARFGAP 3 45 2.32630161961136 NA 4.41827139191616 3.71659512614489 0.70167626577127 1.48885667376979 1.48159444498515 0.473494222644613 0.471285301085848 0.473595367575979 0.431229936362338 NA NA NA 0.503280518666695 99.311357293691 a4993 BRCA1_mut 344 THZ-2-49 CDK9 4 45 2.99573227355399 NA 1.22422272678462 1.83514630813887 -0.610923581354247 1.41575970783643 1.47886958550001 0.414207388595553 0.431516434584695 0.413101728065963 0.431254119071131 NA NA NA 0.460910376056272 99.311357293691 a4994 ARID1A_mut 255 CP724714 ERBB2 5 43 2.32630161961136 NA 3.24188705810916 3.86828552558126 -0.626398467472108 1.8049200978636 1.6563997964111 0.375125048303722 0.34705052495872 0.378168645534319 0.431320838206404 NA NA NA 0.493420543717717 99.311357293691 a4995 MLL3_mut 1049 PD-173074 FGFR1, FGFR3 3 40 0.693147180559945 NA 2.43161678396008 2.97572503034465 -0.544108246384566 1.09569207295607 1.14610248114058 0.475745939417067 0.496588649141741 0.474746591459323 0.431334600546957 NA NA NA 0.484086611239437 99.311357293691 a4996 gain_cnaBRCA63 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 6 41 2.32630161961136 NA 0.952538118042716 1.48489698213141 -0.532358864088692 1.3768068826272 1.55238732946007 0.347068810998441 0.386661971846665 0.342929147891105 0.431348284440265 NA NA NA 0.413290648544963 99.311357293691 a4997 BRCA1_mut 1036 PLX4720 BRAF 4 39 2.30258509299405 NA 5.05193696557329 4.54991606014633 0.502020905426951 0.187407006640594 1.24877941965995 0.417205907772116 2.67877340568017 0.40200927203273 0.43139035553241 NA NA NA 0.0292353100927294 99.311357293691 a4998 gain_cnaBRCA61_(NOTCH2) 205 BMS-708163 g-secretase 3 45 2.32630161961136 0.940007258491471 4.59514076799155 4.91662210092816 -0.321481332936616 0.456542017387655 0.687958277446096 0.473088486862241 0.704165927105989 0.467297717719234 0.431622164195262 NA NA NA 0.347995596998346 99.311357293691 a4999 gain_cnaBRCA10_(MDM2,NUP107) 226 GSK1070916 AURKB 5 44 0.940007258491471 2.32630161961136 3.05918250945542 2.32948920918128 0.729693300274145 1.07476773039224 2.01142824427249 0.374333382689918 0.678931158463273 0.362773716811393 0.431658921834415 NA NA NA 0.23641670548735 99.311357293691 a5000 loss_cnaBRCA60 330 XMD13-2 RIPK 3 45 2.32630161961136 NA 3.18111349865007 3.75701509403768 -0.575901595387608 0.615192194587821 1.23792125513064 0.473024671731454 0.93613280606309 0.465216663015317 0.431683874193332 NA NA NA 0.23997274644529 99.311357293691 a5001 loss_cnaBRCA36_(FAT1,IRF2) 254 AC220 FLT3 9 39 0.0237165266173161 NA 2.43442762273356 2.17514672977101 0.259280892962551 0.557510662044537 0.938295565330647 0.293325742311776 0.465068940586177 0.276331789835522 0.431733315511732 NA NA NA 0.290797634418068 99.311357293691 a5002 loss_cnaBRCA23 167 OSU-03012 PDPK1 (PDK1) 3 45 2.77258872223978 NA 1.72260856172749 2.28300372530809 -0.5603951635806 0.248331636700776 1.21044421896347 0.472919404926888 2.25664023732844 0.462966533113339 0.431785679998276 NA NA NA 0.0316635374004213 99.311357293691 a5003 loss_cnaBRCA17 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 9 37 1.38629436111989 NA 3.21023609537012 2.7730783882228 0.437157707147326 1.35053629620835 1.51024728084909 0.294880860982447 0.323691935103597 0.289461012571099 0.431805225674735 NA NA NA 0.410155063935994 99.311357293691 a5004 loss_cnaBRCA29_(MAP2K4) 176 IPA-3 PAK1, PAK2, PAK3 7 40 3.46573590279973 NA 4.91445325181092 4.42375703468739 0.490696217123525 1.50281572615496 1.51182767660681 0.324829031860037 0.326517888110608 0.324571526713188 0.432032068935694 NA NA NA 0.448130567245857 99.311357293691 a5005 ARID1A_mut 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 38 -1.38629436111989 0.693147180559945 0.338422878563773 -0.369675858010699 0.708098736574472 1.2710550766046 1.72725822803777 0.417190853890403 0.557095242848197 0.409955341407694 0.432079228198918 NA NA NA 0.362247307223866 99.311357293691 a5006 gain_cnaBRCA61_(NOTCH2) 265 Tubastatin A HDAC6 3 46 2.99573227355399 NA 4.23283457893451 4.72168937903741 -0.488854800102903 1.5388527480265 1.00766907049172 0.47194201334847 0.317674839733583 0.485134271179279 0.43233476557873 NA NA NA 0.63915004927154 99.311357293691 a5007 gain_cnaBRCA8_(CHD4,WNK1) 172 Embelin XIAP 3 45 3.46573590279973 NA 2.56424992033598 3.02164966376065 -0.457399743424661 0.88773497265829 0.972078424876168 0.472245217762528 0.515243577770733 0.470537902827058 0.432438041651099 NA NA NA 0.469621340944823 99.311357293691 a5008 gain_cnaBRCA12_(TERT) 1264 SGC0946 Q8TEK3 (DOT1L) 10 36 -0.693147180559945 NA 2.08526174284896 1.9133391967856 0.171922546063364 0.537426730369734 0.624195542818922 0.28302033720775 0.31989950694318 0.275430589085828 0.432752243734751 NA NA NA 0.400680216890478 99.311357293691 a5009 POLR2B_mut 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 3 43 1.63315443905142 NA 1.23246844210935 1.98572008068627 -0.753251638576914 2.30737163620299 1.5513307292113 0.472703466142817 0.326454406719008 0.485551935762831 0.43284193177943 NA NA NA 0.63071619123335 99.311357293691 a5010 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1170 CCT018159 HSP90 5 38 2.30258509299405 NA 3.73967813115501 3.29061134171742 0.449066789437582 1.44227159231438 1.16206379067062 0.376637955120829 0.311360767161041 0.386439017412657 0.433085958988872 NA NA NA 0.535311281478222 99.311357293691 a5011 gain_cnaBRCA14_(RAD21) 51 Dasatinib ABL, SRC, KIT, PDGFR 6 6 0.246860077931526 NA 1.69717441689528 2.2335466620462 -0.536372245150927 1.27356403983008 0.982759924088947 0.471538779129573 0.421158440703532 0.545781560688042 0.433109150150737 NA NA NA 0.434301951855659 99.311357293691 a5012 loss_cnaBRCA23 197 Bryostatin 1 PRKC 3 45 -4.8283137373023 NA -2.37927692015809 -2.83530572328606 0.456028803127974 0.503073023954554 0.983104407016332 0.471493666091901 0.906486298039248 0.463866095882935 0.433165957640475 NA NA NA 0.251744171559276 99.311357293691 a5013 gain_cnaBRCA27_(CLTC,PPM1D) 35 NVP-TAE684 ALK 3 11 0.693147180559945 NA 2.27986746677935 1.63480929080562 0.645058175973737 1.76727651014413 1.07933729276651 0.52821268020312 0.365001273015918 0.597642813138006 0.433176477680014 NA NA NA 0.598583605851464 99.311357293691 a5014 loss_cnaBRCA18 1375 Temozolomide DNA akylating agent 15 31 3.40119738166216 NA 5.78300799070392 5.95679590866458 -0.173787917960667 0.65450379824915 0.718307278050966 0.248752275579445 0.265526217610292 0.241940912017789 0.433252248683881 NA NA NA 0.420081844996419 99.311357293691 a5015 BRCA1_mut 255 CP724714 ERBB2 4 44 2.32630161961136 NA 4.43486708612735 3.74559646695524 0.689270619172108 1.41727589456139 1.68615544032606 0.412751729712978 0.486334821481897 0.408782371237861 0.433373729970454 NA NA NA 0.414008966740235 99.311357293691 a5016 MLL3_mut 1005 Cisplatin DNA crosslinker 3 42 1.79175946922805 2.30258509299405 4.19219898090161 3.63278959234933 0.559409388552278 0.751355450794171 1.20077534535478 0.472609093222337 0.744533613166699 0.465873479761524 0.433385679166678 NA NA NA 0.3267098719953 99.311357293691 a5017 gain_cnaBRCA10_(MDM2,NUP107) 1021 Axitinib PDGFR, KIT, VEGFR 3 42 0.693147180559945 NA 2.97885302420833 2.42545892036677 0.553394103841567 0.494402586625632 1.19465611497785 0.472418929059636 1.11931878758677 0.463224602380098 0.433569424154505 NA NA NA 0.179039680497604 99.311357293691 a5018 gain_cnaBRCA12_(TERT) 274 PXD101, Belinostat HDAC 9 39 2.99573227355399 NA 0.316322875636475 0.753468069888035 -0.43714519425156 0.973165854536292 1.58533273831141 0.292021755295228 0.449199067367461 0.275743497681867 0.433769661698821 NA NA NA 0.301687652362856 99.311357293691 a5019 gain_cnaBRCA62 1375 Temozolomide DNA akylating agent 8 38 3.40119738166216 NA 6.0774688510963 5.86279058474712 0.214678266349181 1.18191959382148 0.562292794103909 0.307275660871432 0.181635254607351 0.381790890084765 0.433808006492838 NA NA NA 0.629791863601147 99.311357293691 a5020 loss_cnaBRCA28_(GPS2) 177 GSK-650394 SGK3 4 43 2.77258872223978 NA 4.65547736508005 3.95480731785249 0.70067004722756 1.48502146940531 1.71151734693254 0.412800349338773 0.471824860221145 0.409385302745154 0.433851702809444 NA NA NA 0.426319850692071 99.311357293691 a5021 gain_cnaBRCA8_(CHD4,WNK1) 193 GW-2580 CSF1R (cFMS) 4 44 2.99573227355399 NA 5.18135588466812 5.48902822960605 -0.307672344937929 1.43155260397865 0.673043764153407 0.412213922979455 0.214922137043955 0.457135718841311 0.433969198584961 NA NA NA 0.698052387722784 99.311357293691 a5022 loss_cnaBRCA22_(SYNCRIP,ZNF292) 310 YM201636 FYV1 19 30 1.63315443905142 NA 2.55883242598754 2.32336302041364 0.235469405573893 0.99807906668224 1.02991082284183 0.231342812876414 0.235922597151173 0.228630868179599 0.434054788497972 NA NA NA 0.43153706467101 99.311357293691 a5023 NF1_mut 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 4 41 2.30258509299405 NA 1.78106911581122 1.32476351772295 0.456305598088264 0.209476061565739 1.14244843568059 0.413596235008506 2.17831858531989 0.39941023492796 0.434109687822165 NA NA NA 0.0357959987508825 99.311357293691 a5024 gain_cnaBRCA58_(CCND1) 265 Tubastatin A HDAC6 10 39 2.99573227355399 NA 4.92228226612573 4.63265109003249 0.289631176093231 1.15830552170501 1.0047169089725 0.279595973099766 0.250047306747617 0.288271426017334 0.434191702495002 NA NA NA 0.482216355628957 99.311357293691 a5025 gain_cnaBRCA10_(MDM2,NUP107) 1043 JNK Inhibitor VIII JNK 3 40 2.30258509299405 NA 5.12560773438923 4.7727104396855 0.352897294703725 0.672951054574818 0.750254617753678 0.472628564890401 0.524402617849662 0.470370040187593 0.43433660855548 NA NA NA 0.46342147986262 99.311357293691 a5026 MLL3_mut 1017 Olaparib PARP1, PARP2 3 42 1.6094379124341 NA 3.6822440460765 4.10208767294217 -0.419843626865672 1.25225456642858 0.868714428682337 0.471615083840361 0.335270190359985 0.48329302818475 0.434346649810605 NA NA NA 0.622292007630289 99.311357293691 a5027 gain_cnaBRCA30_(CRNKL1,FOXA2) 1023 GW 441756 NTRK1 5 40 0.693147180559945 NA 2.79276367017575 2.30510218098458 0.487661489191169 1.71295482017385 1.25320756160305 0.37430743865533 0.284690222677137 0.38913066289464 0.434377643982033 NA NA NA 0.567200751729116 99.311357293691 a5028 gain_cnaBRCA62 1494 SN-38 TOP1 9 39 -2.99573227355399 NA -2.90456542447976 -3.39591691425678 0.491351489777024 2.1701398097807 1.56372017921114 0.29161431653938 0.226414670410879 0.314219574773857 0.434407104676229 NA NA NA 0.535386145908764 99.311357293691 a5029 BRCA1_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 42 1.38629436111989 NA 2.29996002472363 2.91181393151619 -0.611853906792567 0.378201284335071 1.53248693866003 0.41268606822697 1.61779965361114 0.399255544277301 0.434533628858435 NA NA NA 0.0596104908762459 99.311357293691 a5030 gain_cnaBRCA31 228 KIN001-102 AKT1 16 33 2.32630161961136 NA 1.71603227563084 2.05408969069491 -0.338057415064072 1.6165209721079 1.29865486556305 0.240111208490525 0.209126525975877 0.260313516722938 0.434542602799127 NA NA NA 0.472223808759598 99.311357293691 a5031 loss_cnaBRCA42 151 QS11 ARFGAP 3 45 2.32630161961136 NA 4.41345842981836 3.71691599028474 0.696542439533625 1.14171569735816 1.4956901722331 0.469982933194347 0.610083964988278 0.465699683306517 0.434631392380102 NA NA NA 0.404211409323055 99.311357293691 a5032 loss_cnaBRCA17 177 GSK-650394 SGK3 11 36 2.77258872223978 NA 3.66135795044847 4.12232462980678 -0.460966679358309 1.09915317450447 1.8328044094785 0.271572328088818 0.419383476344073 0.251508931872043 0.434662164856619 NA NA NA 0.315069987619457 99.311357293691 a5033 loss_cnaBRCA33 1052 RO-3306 CDK1 5 38 1.6094379124341 NA 3.12692368249852 3.57814042356744 -0.451216741068914 1.41267594209558 1.17737524220822 0.375275838715994 0.319405694981663 0.383239535615372 0.434738952770101 NA NA NA 0.526039273125278 99.311357293691 a5034 gain_cnaBRCA14_(RAD21) 257 NPK76-II-72-1 PLK3 21 28 2.32630161961136 NA 3.27283875485913 3.63355145372545 -0.360712698866323 1.86114467416374 1.34652401351062 0.227427798095786 0.193812283308068 0.267884341643402 0.434749829318929 NA NA NA 0.456732689067418 99.311357293691 a5035 MACF1_mut 1058 GDC0941 PI3K (class 1) 3 40 1.38629436111989 0.693147180559945 1.95557026270037 1.30028499255882 0.655285270141545 2.63410290558609 1.29192651682443 0.472159601719222 0.24876980650676 0.507215589747505 0.434789297228275 NA NA NA 0.709630137766462 99.311357293691 a5036 gain_cnaBRCA16 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 15 30 -0.669430653942629 NA -3.08178461973549 -3.68839492546855 0.606610305733061 2.75718847193749 2.26030823564898 0.249300589628544 0.220010460622155 0.26837503671657 0.434812365371152 NA NA NA 0.468241320882472 99.311357293691 a5037 loss_cnaBRCA7_(FAS,PTEN) 1033 Vismodegib SMO 4 41 2.30258509299405 NA 4.46515267660164 4.78851816900678 -0.323365492405144 0.726995372879997 0.787145557569332 0.412930554305138 0.444797180928579 0.410807746160293 0.434844519443694 NA NA NA 0.450131205171735 99.311357293691 a5038 gain_cnaBRCA12_(TERT) 344 THZ-2-49 CDK9 9 40 2.99573227355399 NA 1.43538457952256 1.86400033894211 -0.428615759419556 1.96578510256189 1.35258908862463 0.290572028661342 0.218037952806218 0.316885418509025 0.434883439571328 NA NA NA 0.548283748401765 99.311357293691 a5039 gain_cnaBRCA10_(MDM2,NUP107) 310 YM201636 FYV1 5 44 1.63315443905142 NA 2.75433509654717 2.37606889144174 0.378266205105432 0.809274124267874 1.03513335296269 0.371627340920537 0.467414184838342 0.36542751136632 0.434973858527192 NA NA NA 0.376711894202094 99.311357293691 a5040 gain_cnaBRCA58_(CCND1) 277 ABT-869 VEGFR and PDGFR family 10 38 0.0237165266173161 NA 2.79651815982659 2.66333090268737 0.133187257139224 0.507150483277623 0.467915344184812 0.27989547663457 0.262618811439276 0.284639644316984 0.435010975217831 NA NA NA 0.46592178476087 99.311357293691 a5041 BRCA1_mut 196 Phenformin AAPK1 (AMPK) agonist 4 44 8.29404964010203 NA 7.88539876802541 7.13988711278 0.74551165524541 0.861631491283555 1.86146424379286 0.411171028053104 0.865232599768187 0.400497435140833 0.435125300214414 NA NA NA 0.197164496422535 99.311357293691 a5042 gain_cnaBRCA15 165 DMOG Prolyl-4-Hydroxylase 21 25 8.29404964010203 NA 7.76465687567782 7.40645248773107 0.358204387946748 1.78207555781134 1.29670391255038 0.233137015028188 0.201004040696612 0.276242235779351 0.435146538277763 NA NA NA 0.448494986398834 99.311357293691 a5043 loss_cnaBRCA7_(FAS,PTEN) 1199 Tamoxifen ER 4 43 1.6094379124341 NA 4.22835913571035 3.83575730011501 0.392601835595335 0.654934355119116 0.971795529065312 0.411553264072043 0.59945219322619 0.403996338584666 0.435232334329302 NA NA NA 0.331586755521068 99.311357293691 a5044 gain_cnaBRCA64_(SDHC) 1133 JNJ-26854165 MDM2 8 35 2.30258509299405 NA 3.18828777777833 2.91865075297776 0.269637024800579 1.19549135459037 0.790670110448977 0.308800705067825 0.225544939129207 0.341023419549105 0.435232384105996 NA NA NA 0.559005945154084 99.311357293691 a5045 gain_cnaBRCA58_(CCND1) 156 AZD6482 PI3Kbeta 9 38 1.63315443905142 NA 1.70808135251487 2.13507443470855 -0.426993082193679 1.56061732707777 1.44117633283535 0.291836746695263 0.273605242480049 0.296280942494814 0.435271445695779 NA NA NA 0.469140511941844 99.311357293691 a5046 PTEN_mut 294 MPS-1-IN-1 MPS1 9 40 2.99573227355399 NA 4.47847296200421 4.81907776966793 -0.340604807663727 1.10128415244451 1.18762427203849 0.290277428316996 0.309279677645128 0.286795088045057 0.435346233815314 NA NA NA 0.424197585100951 99.311357293691 a5047 ASH1L_mut 291 KIN001-266 MAP3K8 (COT) 3 46 2.99573227355399 NA 3.25895791709753 3.81252635408336 -0.553568436985824 1.01707349383782 1.18767049153495 0.468763020989042 0.544275748350291 0.466095976056786 0.435421465383396 NA NA NA 0.448537892666774 99.311357293691 a5048 loss_cnaBRCA38 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 4 45 3.68887945411394 NA 3.00861180877651 3.49953388866976 -0.490922079893252 1.1074792791729 1.20203945134708 0.410392057648818 0.443278794579242 0.408407627006828 0.43548205075348 NA NA NA 0.450559750243169 99.311357293691 a5049 loss_cnaBRCA7_(FAS,PTEN) 312 AV-951 VEGFR 4 44 -2.05572501506252 NA 0.390542360837456 0.654251620014977 -0.263709259177522 0.331749328964734 0.658412843051253 0.410638107345135 0.794905177353214 0.40052265377362 0.435716777842317 NA NA NA 0.225824356685455 99.311357293691 a5050 gain_cnaBRCA13_(FGFR1,WHSC1L1) 62 BMS-536924 IGF1R 3 9 1.63315443905142 NA 3.59078824357155 3.02245453799136 0.568333705580186 0.70808683585111 1.11955358404056 0.541148095276278 0.802632780055934 0.507643147842037 0.435846610437042 NA NA NA 0.345933980094139 99.311357293691 a5051 gain_cnaBRCA58_(CCND1) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 9 36 0.693147180559945 NA 0.28858481111661 0.709814950165479 -0.421230139048869 0.738704053302128 1.55321720804475 0.293117208890284 0.570228547096637 0.271198475568738 0.435878564899777 NA NA NA 0.248416134592072 99.311357293691 a5052 loss_cnaBRCA28_(GPS2) 226 GSK1070916 AURKB 4 45 0.940007258491471 2.32630161961136 3.13760304149419 2.33873390189503 0.798869139599159 0.973504056697227 1.99883414925926 0.409767631109667 0.820612029403817 0.399667546151946 0.436176347691497 NA NA NA 0.214327509835268 99.311357293691 a5053 loss_cnaBRCA28_(GPS2) 235 QL-XII-47 BTK, BMX 4 45 2.32630161961136 NA 1.14165239846938 1.75842377894073 -0.616771380471353 0.797803532752342 1.54196909848624 0.409678817701777 0.773086800384995 0.399989455739963 0.436275152373521 NA NA NA 0.235089436610195 99.311357293691 a5054 gain_cnaBRCA63 235 QL-XII-47 BTK, BMX 7 42 2.32630161961136 NA 1.29443651500302 1.77701485812356 -0.482578343120539 1.4184520333708 1.51782080086374 0.320543426665491 0.340214777635972 0.317941579694994 0.436295325438549 NA NA NA 0.432087787489111 99.311357293691 a5055 gain_cnaBRCA58_(CCND1) 310 YM201636 FYV1 10 39 1.63315443905142 NA 2.64011888081492 2.35685943328265 0.283259447532273 1.07530068962462 1.00382965764365 0.278277134579531 0.263423477977269 0.282178799336516 0.436348548554427 NA NA NA 0.464491552237179 99.311357293691 a5056 loss_cnaBRCA33 288 KIN001-055 JAK3, MNK1 6 43 2.32630161961136 NA 4.08203038682643 4.37486419001575 -0.292833803189321 0.962332449551264 0.842453897165196 0.342093445634374 0.304295883741497 0.347596235443492 0.436406497623372 NA NA NA 0.504749134260547 99.311357293691 a5057 loss_cnaBRCA42 230 GSK429286A ROCK2 3 46 2.99573227355399 2.32630161961136 5.01126745552536 5.43121463800397 -0.419947182478604 0.403637560205784 0.913603735939067 0.467739214857527 1.04040660206276 0.459660097653774 0.436418335643672 NA NA NA 0.202748874667894 99.311357293691 a5058 gain_cnaBRCA15 306 TG101348 JAK2 22 26 2.32630161961136 NA 3.38310312714274 3.09101538163083 0.29208774551191 1.40874908612387 1.16958017256653 0.227428961030953 0.207338374440817 0.249737258174402 0.436421861707093 NA NA NA 0.444025966737525 99.311357293691 a5059 gain_cnaBRCA14_(RAD21) 136 Mitomycin C DNA crosslinker 21 27 2.77258872223978 NA 0.0557835991748773 -0.282152196188191 0.337935795363068 1.30898060874222 1.59907554146292 0.228342575349884 0.258167151679799 0.211331976883285 0.436595347953485 NA NA NA 0.425063608023757 99.311357293691 a5060 loss_cnaBRCA7_(FAS,PTEN) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 4 39 0.693147180559945 NA 3.26624026457737 2.87171904520205 0.394521219375317 0.82820798147665 0.966176853366285 0.412352822710122 0.476355249163268 0.408332302725691 0.43672794573426 NA NA NA 0.423914068591042 99.311357293691 a5061 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 341 EX-527 SIRT1 15 34 2.99573227355399 NA 5.75228155379722 5.59299074687821 0.159290806919007 0.610965363320164 0.673011104923065 0.2431385600396 0.260719864794583 0.23668377201178 0.436737723695633 NA NA NA 0.421661649802285 99.311357293691 a5062 NF1_mut 207 AS601245 JNK 5 43 2.07944154167984 NA 1.83968313150095 2.31579578078416 -0.476112649283218 0.83841946010556 1.31927969084562 0.370622084629049 0.567869273004796 0.360888333677026 0.436834410215152 NA NA NA 0.302342725190599 99.311357293691 a5063 gain_cnaBRCA12_(TERT) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 9 34 0.693147180559945 NA 2.68575543994073 2.96735896652126 -0.281603526580529 0.853901108592474 0.980072192827714 0.294330101972039 0.329784706621016 0.287329370878327 0.436870351616519 NA NA NA 0.408467177612202 99.311357293691 a5064 PIK3CA_mut 301 PHA-793887 CDK-pan 16 32 2.32630161961136 NA 3.18523051206296 2.79078960318842 0.39444090887454 1.39687988971413 1.75005946613256 0.240036478919858 0.282372816574275 0.22538714627007 0.437084327311288 NA NA NA 0.403321081219286 99.311357293691 a5065 gain_cnaBRCA31 52 GNF-2 ABL [T315I] 3 9 0.246860077931526 NA 2.71639357445098 2.41031920396399 0.306074370486987 0.472734376985723 0.58849205799701 0.53959146117191 0.647455284378929 0.520099407167432 0.437127130260128 NA NA NA 0.410507069936296 99.311357293691 a5066 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1166 QL-VIII-58 MTOR, ATR 9 17 2.30258509299405 NA -1.27968900885182 -1.64573546067508 0.366046451823251 1.04148454049492 1.16267486391634 0.325741990148068 0.351466044468893 0.314831311128774 0.437154060668691 NA NA NA 0.423759969341392 99.311357293691 a5067 gain_cnaBRCA58_(CCND1) 344 THZ-2-49 CDK9 10 39 2.99573227355399 NA 2.11133397905509 1.70167012776504 0.409663851290051 0.986177006516334 1.56882411842277 0.277704968432636 0.415406005801318 0.261127966149519 0.437286255563908 NA NA NA 0.317301343629084 99.311357293691 a5068 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1161 ZG-10 IRAK1 5 21 2.30258509299405 NA 2.42123435949558 1.86926208192224 0.551972277573341 1.98662929276117 1.25570574455514 0.393086408526001 0.277843621648287 0.439571356559246 0.437296602901262 NA NA NA 0.579652098425958 99.311357293691 a5069 ARID1A_mut 310 YM201636 FYV1 5 44 1.63315443905142 NA 2.07675462094309 2.45306667276039 -0.376312051817299 1.05886093970166 1.01404231904244 0.369682354337897 0.355393269982484 0.37110093410367 0.437365834910604 NA NA NA 0.484435411716057 99.311357293691 a5070 loss_cnaBRCA36_(FAT1,IRF2) 202 GSK-1904529A IGF1R 9 39 0.0237165266173161 NA 2.3858624056911 2.14440027548993 0.241462130201171 0.496435366831429 0.888462684756131 0.289650092738564 0.486391877642275 0.271775207157347 0.437487989555544 NA NA NA 0.280638644776075 99.311357293691 a5071 gain_cnaBRCA61_(NOTCH2) 157 JNK-9L JNK 3 44 1.63315443905142 NA -0.406507631408925 0.0873682930011241 -0.493875924410049 0.759517696393019 1.06857536939151 0.46734894924623 0.650249397420872 0.462181647225577 0.437605392301985 NA NA NA 0.37941794866863 99.311357293691 a5072 gain_cnaBRCA64_(SDHC) 1020 Lenalidomide TNFA 9 36 1.6094379124341 NA 4.42081063912204 4.21320556132467 0.207605077797366 1.03566961413294 0.613109417387826 0.291989593065187 0.200454927869224 0.338610159801287 0.4376336168358 NA NA NA 0.577666511262343 99.311357293691 a5073 loss_cnaBRCA22_(SYNCRIP,ZNF292) 255 CP724714 ERBB2 18 30 2.32630161961136 NA 4.04668192421149 3.65684794182445 0.389833982387045 1.81575124786146 1.57856688417554 0.233412488160774 0.214695698458795 0.246954364933767 0.437704194864716 NA NA NA 0.455445567860849 99.311357293691 a5074 gain_cnaBRCA58_(CCND1) 190 Bleomycin DNA damage 9 39 4.15888308335967 NA 2.72398309735921 1.92941824686101 0.794564850498203 2.29361478775219 2.83220506130057 0.289339260475176 0.346424715580466 0.280546370513629 0.437976717624017 NA NA NA 0.386253578599963 99.311357293691 a5075 loss_cnaBRCA24 1378 Bleomycin (50 uM) DNA damage 3 45 3.91202300542815 NA 4.63824728389867 3.75768230178877 0.880564982109896 2.17888616159864 1.87349349428356 0.466450598469433 0.404135377804147 0.470012297772419 0.43806933173623 NA NA NA 0.559221587046933 99.311357293691 a5076 gain_cnaBRCA19 1024 CEP-701 FLT3, JAK2, NTRK1, RET 4 41 0.693147180559945 NA 0.0887096724818962 0.677945434538516 -0.58923576205662 1.26621236893165 1.44917822898427 0.40999747763465 0.465353029645238 0.406599926959719 0.438091126590449 NA NA NA 0.43257834054379 99.311357293691 a5077 loss_cnaBRCA17 298 OSI-930 KIT, VEGFR, PDGFR 10 38 2.32630161961136 NA 4.10587984140955 3.8627061003982 0.24317374101135 0.92052386016846 0.863188660757154 0.278007468733913 0.26416886246365 0.281715634213786 0.43809476874523 NA NA NA 0.464519603654622 99.311357293691 a5078 gain_cnaBRCA14_(RAD21) 1028 VX-702 p38 20 25 0.693147180559945 NA 3.51611586146722 3.35540388807494 0.160711973392284 0.797862103439544 0.579166604039047 0.234797425986122 0.201428257714538 0.277488329388289 0.438117072999272 NA NA NA 0.455182034073046 99.311357293691 a5079 PTEN_mut 223 ZSTK474 PI3K 9 40 1.63315443905142 2.32630161961136 0.571057764559981 0.989126005606355 -0.418068241046374 1.23193586171327 1.48965689586159 0.288515897651527 0.339358771864114 0.280647337120251 0.438119575581744 NA NA NA 0.392271533925728 99.311357293691 a5080 loss_cnaBRCA22_(SYNCRIP,ZNF292) 62 BMS-536924 IGF1R 3 9 1.63315443905142 NA 2.74033566370346 3.30593873128073 -0.565603067577265 1.21084735970622 1.00651874870166 0.538378073984038 0.467113433450846 0.561939922437466 0.43812702248898 NA NA NA 0.518737755911663 99.311357293691 a5081 ARID1A_mut 1017 Olaparib PARP1, PARP2 5 40 1.6094379124341 NA 3.78035232802355 4.11081631904207 -0.330463991018527 1.07583234476711 0.869070641937524 0.371169329068736 0.307170529521554 0.380249861256139 0.438212636133309 NA NA NA 0.540102223947008 99.311357293691 a5082 loss_cnaBRCA42 345 KIN001-270 CDK9 3 46 2.99573227355399 NA 4.80550249424729 5.12728815082422 -0.321785656576933 0.322080267574886 0.70286951982262 0.465712100783811 0.999085287030553 0.457817059214831 0.438396117260562 NA NA NA 0.216825257762018 99.311357293691 a5083 gain_cnaBRCA64_(SDHC) 164 JQ12 HDAC 8 39 1.63315443905142 NA 1.99152290099406 1.49303399598729 0.498488905006771 1.27519281934195 1.70216239956554 0.303392690487282 0.390912572158312 0.292856254570073 0.438491525162979 NA NA NA 0.361653027781863 99.311357293691 a5084 loss_cnaBRCA20 261 TL-1-85 MAP3K7 (TAK1) 3 46 2.32630161961136 NA 4.55492661158675 3.99023341296592 0.564693198620829 0.86303566684239 1.22632773916615 0.465501038349178 0.65431038405039 0.46047494530687 0.438602348494495 NA NA NA 0.376783438671784 99.311357293691 a5085 NF1_mut 308 XL-880 MET 5 44 1.63315443905142 NA 2.37930372212287 1.78732300944254 0.591980712680331 1.83237792616708 1.58314051309121 0.36863806110715 0.323066930804291 0.373928092790981 0.438653341925153 NA NA NA 0.52068655532256 99.311357293691 a5086 gain_cnaBRCA12_(TERT) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 9 38 0.940007258491471 NA 2.18243861839021 1.81907924784633 0.363359370543882 1.159822884144 1.27412405028914 0.289629727116796 0.313288671495783 0.285183668310337 0.438728415691955 NA NA NA 0.422151099489667 99.311357293691 a5087 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 176 IPA-3 PAK1, PAK2, PAK3 14 33 3.46573590279973 NA 4.23249856125598 4.60898406947237 -0.376485508216396 1.4262246811306 1.54401737693422 0.249174368019425 0.263973491131808 0.243835020149799 0.438761748073883 NA NA NA 0.426740794025383 99.311357293691 a5088 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1264 SGC0946 Q8TEK3 (DOT1L) 6 40 -0.693147180559945 NA 1.77001951661057 1.97781778532769 -0.207798268717128 0.55545018988965 0.613931349935412 0.342015737947913 0.374107836309158 0.338471506201775 0.438857026906376 NA NA NA 0.427502852318272 99.311357293691 a5089 loss_cnaBRCA20 256 JW-7-24-1 LCK 3 45 2.32630161961136 NA 1.32925357450179 1.87145683224887 -0.542203257747082 0.318268363451908 1.18920605465116 0.465427201272198 1.70360400218984 0.455937182312894 0.439068390691504 NA NA NA 0.0703985467019268 99.311357293691 a5090 MLL3_mut 288 KIN001-055 JAK3, MNK1 3 46 2.32630161961136 NA 3.96529208659582 4.36337970069236 -0.398087614096539 0.382388280060919 0.871164888191068 0.46501767313757 1.0410560021168 0.456960122581557 0.439074866284159 NA NA NA 0.202608758585099 99.311357293691 a5091 gain_cnaBRCA30_(CRNKL1,FOXA2) 1016 Temsirolimus MTOR 5 39 -1.6094379124341 NA -1.25755901364089 -1.81419505468893 0.556636041048039 0.606567735117078 1.5647129534261 0.371074772555083 0.917681585784643 0.355743230622094 0.439076572794434 NA NA NA 0.156067276496338 99.311357293691 a5092 NF1_mut 1502 Bicalutamide ANDR (androgen receptor) 5 40 2.30258509299405 NA 4.75065093560101 4.53425965761744 0.216391277983566 0.44404009626196 0.596619075065836 0.370463587554598 0.487323734512269 0.362695875856278 0.439077870340011 NA NA NA 0.363125061778678 99.311357293691 a5093 loss_cnaBRCA57 1010 Gefitinib EGFR 5 40 -0.693147180559945 NA 1.74327916515812 1.35697514586877 0.386304019289349 1.06285464064637 1.0406773040054 0.370462946117207 0.363458938330852 0.371204424082784 0.439078657199585 NA NA NA 0.477112191161564 99.311357293691 a5094 gain_cnaBRCA8_(CHD4,WNK1) 1248 FK866 NAMPT 3 41 0 NA 0.531511475819661 -0.737209578623605 1.26872105444327 1.93963764625968 2.74990832692068 0.466989363527078 0.654102098342862 0.461368490732187 0.439305876883619 NA NA NA 0.377533281897909 99.311357293691 a5095 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1022 AZD7762 CHEK1, CHEK2 17 28 0.693147180559945 NA 1.14722686475358 0.757533005429211 0.389693859324367 1.8270363882442 1.49143808285528 0.239895517059768 0.213292883399475 0.261287319805003 0.439532886510142 NA NA NA 0.464077583748408 99.311357293691 a5096 gain_cnaBRCA47_(EGFR) 205 BMS-708163 g-secretase 7 41 2.32630161961136 0.940007258491471 5.0816393056181 4.86492540747354 0.216713898144556 0.590017420643521 0.692145386430639 0.318839848358358 0.367300846656681 0.313104591019727 0.43959706799475 NA NA NA 0.404408222139228 99.311357293691 a5097 gain_cnaBRCA62 1010 Gefitinib EGFR 8 37 -0.693147180559945 NA 1.66059062743518 1.34353180110973 0.317058826325456 1.19255118800952 1.01108798261882 0.304050743707901 0.265866010208464 0.313581836374162 0.439777296377549 NA NA NA 0.50130943908126 99.311357293691 a5098 loss_cnaBRCA18 32 VX-680 AURKA, AURKB, AURKC, FLT3, ABL1, JAK2 5 7 0.693147180559945 NA 1.78632425331939 0.766010519114341 1.02031373420504 1.54641011631356 2.49528969368585 0.471014795462439 0.659795046243838 0.408895903664763 0.439864538858225 NA NA NA 0.403649909173397 99.311357293691 a5099 gain_cnaBRCA27_(CLTC,PPM1D) 1007 Docetaxel Microtubules 10 35 -4.38202663467388 NA -4.25134318305272 -4.68326150480556 0.431918321752839 1.42878363604848 1.57439531807262 0.279548938769418 0.302297920311696 0.274339180760265 0.439881929141165 NA NA NA 0.42235661943533 99.311357293691 a5100 gain_cnaBRCA64_(SDHC) 300 CX-5461 RNA Pol I 8 41 2.32630161961136 NA 3.4816897160924 3.99639955217618 -0.514709836083777 1.88637060502227 1.67685146029452 0.301055449749234 0.272857218360706 0.30695016718617 0.439938977478975 NA NA NA 0.490212860397877 99.311357293691 a5101 gain_cnaBRCA16 303 PIK-93 PI4K, PI3K 16 33 2.99573227355399 NA 2.56419800798713 2.90174741381569 -0.33754940582856 1.46631177204235 1.40274616856872 0.237152784822839 0.230203025212301 0.24063470169587 0.440188200447716 NA NA NA 0.449740476709022 99.311357293691 a5102 gain_cnaBRCA61_(NOTCH2) 344 THZ-2-49 CDK9 3 46 2.99573227355399 NA 1.14281722739998 1.82717441502582 -0.684357187625836 1.39552546106716 1.4787427357771 0.463877506750882 0.490393910192441 0.462796652229163 0.440190640513912 NA NA NA 0.488448124457282 99.311357293691 a5103 loss_cnaBRCA23 1218 JQ1 BRD2, BRD3, BRD4 3 43 0 NA 2.15244533420527 2.47929837464467 -0.326853040439403 1.27614178557214 0.663254244336478 0.465069298488363 0.256125960402482 0.492802033655115 0.440258025353582 NA NA NA 0.70183284407155 99.311357293691 a5104 loss_cnaBRCA33 273 CUDC-101 HDAC, EGFR 6 43 1.63315443905142 NA -0.49395628944198 0.0385572251909598 -0.53251351463294 1.1083867430411 1.61642827008748 0.339134332633849 0.480440169441103 0.329438382443113 0.440359300296007 NA NA NA 0.330498838287659 99.311357293691 a5105 gain_cnaBRCA12_(TERT) 301 PHA-793887 CDK-pan 9 39 2.32630161961136 NA 2.53794779192587 3.01095962481292 -0.473011832887047 1.8069622619059 1.60685710897359 0.287823530401618 0.261771838216552 0.29437081259154 0.440364574380815 NA NA NA 0.48510912256228 99.311357293691 a5106 CDH1_mut 175 PAC-1 CASP3 agonist 4 44 0.940007258491471 NA 1.94543043108353 2.4428319250408 -0.497401493957269 1.15221085804132 1.22873835025701 0.406409199127483 0.431693114576977 0.404806681465773 0.440427307776274 NA NA NA 0.461399565400515 99.311357293691 a5107 gain_cnaBRCA15 263 FR-180204 ERK 22 27 2.99573227355399 NA 5.26752558495785 5.43151098926088 -0.163985404303023 0.776585838823133 0.697469478518322 0.223451657621129 0.211161981206782 0.235114810545384 0.440468914021621 NA NA NA 0.445905474532234 99.311357293691 a5108 loss_cnaBRCA23 1239 YK 4-279 RNA helicase A 3 39 2.30258509299405 NA 2.57536278542741 1.97033673358952 0.605026051837887 0.638957210462227 1.32163584397984 0.466815721350099 0.946896039251527 0.457785746802972 0.440484515917071 NA NA NA 0.237249038703662 99.311357293691 a5109 gain_cnaBRCA16 203 BMS-345541 IKBKB 16 33 2.77258872223978 NA 3.37125854561125 3.61042843626221 -0.239169890650961 1.17316865983681 0.922375806036718 0.236987208692084 0.203866586995453 0.259297662715842 0.440505449829981 NA NA NA 0.48124178219589 99.311357293691 a5110 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1036 PLX4720 BRAF 15 28 2.30258509299405 NA 4.79194514693516 4.49197489299903 0.299970253936138 0.840418871719486 1.3541655772617 0.249216783363066 0.35692945985661 0.221516673420925 0.440525856361706 NA NA NA 0.376661953952043 99.311357293691 a5111 gain_cnaBRCA14_(RAD21) 192 LFM-A13 BTK 21 27 2.77258872223978 NA 4.90210936788158 4.71252849033568 0.189580877545906 0.957784016240226 0.731903129962716 0.226329966611071 0.197936981961866 0.259024548174241 0.440622077969464 NA NA NA 0.456760250447562 99.311357293691 a5112 NF1_mut 257 NPK76-II-72-1 PLK3 5 44 2.32630161961136 NA 4.00169373850696 3.41955876963226 0.5821349688747 0.98900703417208 1.63080044446654 0.366971733428015 0.588605488900307 0.35696272394942 0.440712403227025 NA NA NA 0.288863927436623 99.311357293691 a5113 MLL3_mut 201 Epothilone B Microtubules 3 45 -3.44201937618241 NA -5.02110573464852 -4.18340140411471 -0.837704330533816 1.62304664644452 1.81428917146272 0.46374362937834 0.516130779339527 0.461725916524343 0.440714861983429 NA NA NA 0.469125154172362 99.311357293691 a5114 loss_cnaBRCA38 1495 AZD-2281 PARP1, PARP2 3 42 2.30258509299405 NA 4.48962043878514 3.96362492968176 0.525995509103381 0.461040212700128 1.15389199120237 0.465023296805032 1.14088857026773 0.455844665803847 0.440751511181911 NA NA NA 0.173259177995319 99.311357293691 a5115 loss_cnaBRCA34 1203 QL-XII-61 BTK 3 20 2.30258509299405 NA 3.58520690872044 4.32121165747208 -0.736004748751645 0.606364418096157 1.57837533981386 0.486469522598714 1.21379937012552 0.466305276182562 0.440807836920225 NA NA NA 0.180356173470432 99.311357293691 a5116 BRCA2_mut 290 KIN001-260 IKK 6 43 2.99573227355399 NA 4.73402820752176 5.08733578768458 -0.353307580162816 0.561880794412799 1.08614367534528 0.338750345000021 0.628794548018044 0.325286228868846 0.440873782737994 NA NA NA 0.237217107599791 99.311357293691 a5117 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 55 A-770041 SRC family 3 9 1.63315443905142 NA 3.18509965202127 2.54488527592124 0.640214376100038 0.938923843655454 1.25283652423799 0.535001080131848 0.681859748717778 0.511011902761561 0.440917829205654 NA NA NA 0.395322594507624 99.311357293691 a5118 PTEN_mut 134 Etoposide TOP2 8 39 2.77258872223978 NA 1.93592603154605 2.58811208981374 -0.652186058267694 2.06241337853469 2.1790753592538 0.30175057463124 0.316224703085984 0.299294861693553 0.440957349332374 NA NA NA 0.437721479828228 99.311357293691 a5119 loss_cnaBRCA24 1502 Bicalutamide ANDR (androgen receptor) 3 42 2.30258509299405 NA 4.81167323237007 4.54020526870458 0.271467963665488 0.343259214283159 0.59339900408213 0.464727335984924 0.790854119480536 0.457479641519445 0.441040388267701 NA NA NA 0.3036660173212 99.311357293691 a5120 gain_cnaBRCA12_(TERT) 1032 Afatinib ERBB2, EGFR 10 35 -0.693147180559945 NA 0.688127613890235 0.176855722539398 0.511271891350837 1.26846068855302 1.9563274068672 0.278799843381117 0.403064829651177 0.26134270243117 0.44109987420574 NA NA NA 0.335767374651292 99.311357293691 a5121 BRCA2_mut 279 BIX02189 MAP2K5 (MEK5) 6 43 2.99573227355399 NA 4.75970549277641 5.06470263316415 -0.304997140387744 0.699050196171488 0.922014346050016 0.338539102196341 0.436302202700368 0.330794354441855 0.441156966097735 NA NA NA 0.3669666656012 99.311357293691 a5122 loss_cnaBRCA57 226 GSK1070916 AURKB 5 44 0.940007258491471 2.32630161961136 3.0456785011554 2.331023755579 0.714654745576398 1.25750564663878 2.00211526136913 0.366518531770807 0.568311361055608 0.35694985167222 0.44127340685296 NA NA NA 0.302007399155941 99.311357293691 a5123 loss_cnaBRCA34 1061 SB590885 BRAF 5 37 1.6094379124341 NA 3.65639557139172 4.05995441601252 -0.403558844620796 0.812512263034673 1.11571324904289 0.370510119821218 0.496680312385112 0.361704806290493 0.441374672772474 NA NA NA 0.358265060764365 99.311357293691 a5124 gain_cnaBRCA19 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 41 2.30258509299405 NA 3.66008892680238 3.12972337347869 0.53036555332369 1.13210529942416 1.31572476522286 0.40679893094824 0.468477228746705 0.403097644235537 0.44164797881399 NA NA NA 0.430164130291882 99.311357293691 a5125 gain_cnaBRCA47_(EGFR) 305 TPCA-1 IKK 7 42 2.99573227355399 NA 3.80300305973181 4.24088024997968 -0.437877190247867 1.0931674880567 1.41980918232184 0.316748133760327 0.400558189876533 0.308405661619823 0.441711785279463 NA NA NA 0.371762887574809 99.311357293691 a5126 loss_cnaBRCA20 1230 IOX2 EGLN1 3 44 -2.30258509299405 NA 0.533249999480808 0.230113579093042 0.303136420387766 0.237277072074158 0.667610944509834 0.463142503230696 1.27756305208042 0.454061490274596 0.441713520097163 NA NA NA 0.138641603071423 99.311357293691 a5127 gain_cnaBRCA61_(NOTCH2) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 3 44 2.32630161961136 NA 2.08189892585394 1.37159791359278 0.710301012261161 1.17294137217422 1.54911113138576 0.462932225060231 0.605572477117518 0.458521663081562 0.441919480708982 NA NA NA 0.407386951195178 99.311357293691 a5128 loss_cnaBRCA38 310 YM201636 FYV1 4 45 1.63315443905142 NA 2.03652838142504 2.44827984845494 -0.411751467029896 1.14257436691222 1.00902114995766 0.404443411887128 0.360371700043161 0.408070204521652 0.442123016145852 NA NA NA 0.530137260754914 99.311357293691 a5129 BRCA1_mut 203 BMS-345541 IKBKB 4 45 2.77258872223978 NA 3.90719358208594 3.49901112884643 0.408182453239507 1.65627506089034 0.949214187644402 0.404439034458234 0.246446054087228 0.430021441475148 0.442127924960711 NA NA NA 0.658620056385293 99.311357293691 a5130 TP53_mut 194 AUY922 HSP90 37 10 -1.36257783450257 NA -2.29207036274869 -2.76995090945047 0.477880546701787 1.70099146256106 1.83888207265143 0.276319482519726 0.28094235463256 0.259875580826532 0.442224356834273 NA NA NA 0.471647634950152 99.311357293691 a5131 ASH1L_mut 1192 GSK269962A ROCK1, ROCK2 3 43 1.6094379124341 NA 2.03369981681945 2.71219320703883 -0.678493390219387 2.31581589805855 1.41206635966892 0.463044163725554 0.292982439056661 0.480496816295851 0.442237893227108 NA NA NA 0.663874512000702 99.311357293691 a5132 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 157 JNK-9L JNK 6 41 1.63315443905142 NA -0.256400587857717 0.101538671340707 -0.357939259198424 0.673580854540951 1.09543731482234 0.338665019067438 0.53139761438493 0.326754670810603 0.442510851697126 NA NA NA 0.296427296469079 99.311357293691 a5133 gain_cnaBRCA14_(RAD21) 35 NVP-TAE684 ALK 6 8 0.693147180559945 NA 1.47342179766924 1.99774672664805 -0.524324928978816 1.10033619623294 1.30278600771673 0.428891063006096 0.476513388157066 0.402464353986845 0.442529216528717 NA NA NA 0.431302062067145 99.311357293691 a5134 gain_cnaBRCA48 263 FR-180204 ERK 5 44 2.99573227355399 NA 5.11719925668978 5.38523552944699 -0.268036272757207 1.28061841350267 0.660449868674089 0.365209929468751 0.209302216750181 0.40583893717068 0.442895651153229 NA NA NA 0.667370470763028 99.311357293691 a5135 gain_cnaBRCA13_(FGFR1,WHSC1L1) 283 GSK2126458 PI3K, MTOR 11 37 -2.05572501506252 0.0237165266173161 -3.39050145919555 -2.95572063084294 -0.434780828352608 0.899842938858109 1.78727102184867 0.265785962657487 0.483174129147849 0.243265192037239 0.44292447220846 NA NA NA 0.284585762250749 99.311357293691 a5136 gain_cnaBRCA9_(KRAS) 136 Mitomycin C DNA crosslinker 4 44 2.77258872223978 NA -0.682604767462729 -0.0844598782854051 -0.598144889177324 1.36889614961786 1.4876798419602 0.404090884110006 0.436954176066828 0.402065600612828 0.443022402485833 NA NA NA 0.45679890921168 99.311357293691 a5137 BRCA2_mut 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 5 38 1.6094379124341 NA 2.45537101628039 3.01045075283786 -0.555079736557468 1.14206831038186 1.54148651651973 0.368288867897014 0.486030241371354 0.360093799464878 0.443277168227814 NA NA NA 0.366071284704481 99.311357293691 a5138 gain_cnaBRCA12_(TERT) 1022 AZD7762 CHEK1, CHEK2 10 35 0.693147180559945 NA 0.554206683068808 1.00490611491831 -0.450699431849497 1.21224073652841 1.71728378446717 0.277418205361819 0.371790369906394 0.262449011587993 0.443351502116533 NA NA NA 0.359514842415466 99.311357293691 a5139 loss_cnaBRCA22_(SYNCRIP,ZNF292) 206 Ruxolitinib JAK1, JAK2, TYK2 19 30 1.65632149833295 0.0237165266173161 4.4610045491559 4.31278919100841 0.148215358147481 0.90160162409679 0.434651744212362 0.226583744757535 0.164391183629422 0.340997960139477 0.443508855612884 NA NA NA 0.510038884562596 99.311357293691 a5140 gain_cnaBRCA16 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 16 32 2.77258872223978 NA -0.214188836472442 -0.547696384071451 0.333507547599009 1.09283903113872 1.5394152017743 0.236626406766743 0.305175362607153 0.216645611407901 0.443582749060568 NA NA NA 0.392226771942295 99.311357293691 a5141 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1170 CCT018159 HSP90 17 26 2.30258509299405 NA 3.5168390244338 3.22905223944856 0.287786784985244 1.4913963730986 0.953658794567731 0.241288157127269 0.192964653915125 0.301771227429083 0.443608829859388 NA NA NA 0.486381069557809 99.311357293691 a5142 ARID1A_mut 135 Gemcitabine DNA replication 5 42 0.0237165266173161 NA -1.17917892993451 -0.167610015425195 -1.01156891450932 1.98134167288447 2.83147705398666 0.365648224101369 0.510547437805947 0.357258383247376 0.443621581980529 NA NA NA 0.344476021460312 99.311357293691 a5143 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1114 Cetuximab EGFR 6 39 4.18661983833127 NA 6.02455250331466 6.32228237079745 -0.297729867482788 1.0785887532062 0.8489890344038 0.338801314996455 0.2760365028819 0.350687530012526 0.443993510195046 NA NA NA 0.542179825331441 99.311357293691 a5144 gain_cnaBRCA61_(NOTCH2) 273 CUDC-101 HDAC, EGFR 3 46 1.63315443905142 NA 0.651322733249387 -0.0708640272432341 0.722186760492621 1.57239851883894 1.57028834668863 0.45988078600902 0.45928990128144 0.459907100511536 0.444115090026978 NA NA NA 0.513004196293024 99.311357293691 a5145 NF1_mut 1069 EHT 1864 Rac GTPases 5 41 2.30258509299405 NA 3.8417336103536 3.5272373125394 0.314496297814191 0.626415516446945 0.879704762720785 0.365792274556031 0.50205700458703 0.357502097455406 0.444121163819762 NA NA NA 0.351655948934375 99.311357293691 a5146 loss_cnaBRCA28_(GPS2) 1004 Vinblastine Microtubules 3 42 -2.30258509299405 NA -2.90210968784218 -3.495092546208 0.592982858365821 1.20516626569286 1.28859918153408 0.461523184210231 0.492034066374161 0.460176342545768 0.444175032083159 NA NA NA 0.487629493978243 99.311357293691 a5147 loss_cnaBRCA38 207 AS601245 JNK 4 44 2.07944154167984 NA 1.79163308623207 2.30934322468853 -0.517710138456467 0.533566150866685 1.32147963544231 0.402916467744537 0.970282949200464 0.391765506309285 0.44434046850874 NA NA NA 0.163184131686796 99.311357293691 a5148 gain_cnaBRCA58_(CCND1) 291 KIN001-266 MAP3K8 (COT) 10 39 2.99573227355399 NA 4.03564142466009 3.71273517416733 0.322906250492762 0.868897103141592 1.24374676972928 0.27336865677402 0.3716277213093 0.259623790269659 0.444431739681939 NA NA NA 0.352892079732645 99.311357293691 a5149 CDH1_mut 283 GSK2126458 PI3K, MTOR 4 44 -2.05572501506252 0.0237165266173161 -3.65936640521744 -3.00044804026068 -0.658918364956752 1.28880351290396 1.65740881963774 0.402785720743506 0.511263632011726 0.397559345135362 0.444487350802721 NA NA NA 0.394851705461033 99.311357293691 a5150 gain_cnaBRCA10_(MDM2,NUP107) 230 GSK429286A ROCK2 5 44 2.99573227355399 2.32630161961136 5.69894351285116 5.37215813978415 0.326785373067005 0.940772019155118 0.893947148082292 0.363892470160885 0.347358729228025 0.365553348168322 0.444532425074101 NA NA NA 0.493652728027351 99.311357293691 a5151 loss_cnaBRCA42 150 Bicalutamide ANDR (androgen receptor) 3 45 0.0237165266173161 NA 2.49353776642268 2.78052440858804 -0.28698664216536 0.236673886527263 0.63619275678046 0.459794535773097 1.21258262318814 0.451100140809044 0.444591244081667 NA NA NA 0.153823975102038 99.311357293691 a5152 gain_cnaBRCA58_(CCND1) 1053 MK-2206 AKT1, AKT2 8 34 1.38629436111989 0.693147180559945 0.98943062660282 1.48904338843122 -0.499612761828396 1.60635784919432 1.65536708589411 0.303366354873639 0.311022081461476 0.301813879281368 0.444641441278529 NA NA NA 0.448291936130435 99.311357293691 a5153 gain_cnaBRCA62 222 BX-912 PDPK1 (PDK1) 10 39 2.32630161961136 NA 3.55476233563982 3.96814448351852 -0.413382147878701 2.3789868195971 1.2217149435333 0.273139493701451 0.173763950465565 0.338362193297863 0.444811264488281 NA NA NA 0.606198777023769 99.311357293691 a5154 gain_cnaBRCA31 62 BMS-536924 IGF1R 3 9 1.63315443905142 NA 3.58275244772082 3.02513313660828 0.55761931111254 0.955959659350726 1.07409274504363 0.530294109655199 0.583308412293535 0.51915378228338 0.444827348998101 NA NA NA 0.44593960610748 99.311357293691 a5155 loss_cnaBRCA33 175 PAC-1 CASP3 agonist 6 42 0.940007258491471 NA 2.04115604398431 2.45284262291008 -0.411686578925768 1.12783891031968 1.2352677264374 0.336332195408547 0.365022500251456 0.333277207940258 0.444864167862206 NA NA NA 0.436609598454903 99.311357293691 a5156 gain_cnaBRCA16 1042 BIRB 0796 p38, JNK2 14 29 2.30258509299405 NA 4.52319388415351 4.2909963610353 0.232197523118214 0.860822372818564 0.95331829406428 0.251026447368502 0.269739182495846 0.243567677830126 0.44492581167669 NA NA NA 0.430433533393106 99.311357293691 a5157 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1007 Docetaxel Microtubules 17 28 -4.38202663467388 NA -4.35941259076428 -4.72562751627604 0.366214925511756 2.00522473435153 1.19174374377867 0.236986626414451 0.182630365184572 0.30729334844301 0.445061775708901 NA NA NA 0.501255556673771 99.311357293691 a5158 gain_cnaBRCA27_(CLTC,PPM1D) 254 AC220 FLT3 9 39 0.0237165266173161 NA 2.01910898734015 2.27098949178487 -0.251880504444724 0.674112551999393 0.922438565897838 0.284844055919288 0.373647551432851 0.273059381683116 0.4450808047342 NA NA NA 0.363027149129067 99.311357293691 a5159 gain_cnaBRCA47_(EGFR) 292 Masitinib KIT 7 41 2.99573227355399 NA 3.7168935107774 4.06042584710481 -0.343532336327407 0.802681210533671 1.12766150484172 0.314942614246737 0.427981036330732 0.304641361660763 0.445172806278961 NA NA NA 0.349366693576267 99.311357293691 a5160 gain_cnaBRCA61_(NOTCH2) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 3 44 2.77258872223978 NA 5.45234807491596 4.98080285164401 0.471545223271958 0.160179614871621 1.04899783646459 0.459605713977627 2.94385289694877 0.449519729098006 0.445185241239898 NA NA NA 0.0173015562641199 99.311357293691 a5161 loss_cnaBRCA20 1218 JQ1 BRD2, BRD3, BRD4 3 43 0 NA 2.15584657901117 2.47906107849542 -0.32321449948425 1.25892594251836 0.664937875065905 0.459821963482029 0.256738294579655 0.486082251597135 0.445398908425797 NA NA NA 0.701220269636271 99.311357293691 a5162 PTEN_mut 228 KIN001-102 AKT1 9 40 2.32630161961136 NA 1.61729643747637 2.01714520664345 -0.399848769167083 1.16978893521596 1.45244999414383 0.283913016183238 0.341812746838186 0.275292623346237 0.445415634950721 NA NA NA 0.391674680330206 99.311357293691 a5163 loss_cnaBRCA38 1004 Vinblastine Microtubules 3 42 -2.30258509299405 NA -4.00713115513686 -3.41616244140124 -0.590968713735621 2.35563598408433 1.20864254205153 0.459933928953604 0.250874378608773 0.488952434797241 0.44573468375179 NA NA NA 0.707425707968246 99.311357293691 a5164 NF1_mut 282 EKB-569 EGFR 4 43 0.916290731874155 2.99573227355399 0.799393223998697 1.65050226397347 -0.85110903997477 3.38438916701181 1.99750015999459 0.401770025052159 0.251480842767926 0.426087094770033 0.446153805958847 NA NA NA 0.652630444117918 99.311357293691 a5165 loss_cnaBRCA17 51 Dasatinib ABL, SRC, KIT, PDGFR 3 9 0.246860077931526 NA 2.41715908070115 1.81476102572727 0.602398054973885 0.30448061606499 1.26491566602642 0.52863273758359 1.97844467985872 0.476235745317509 0.446212694702215 NA NA NA 0.217156702885726 99.311357293691 a5166 loss_cnaBRCA17 269 NSC-207895 MDM4 11 38 2.99573227355399 NA 4.36136375736673 4.67416253274264 -0.312798775375914 0.871857241920915 1.26147764183553 0.263006898282518 0.358772927878355 0.247962203214931 0.446228871936339 NA NA NA 0.357322544313735 99.311357293691 a5167 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1494 SN-38 TOP1 6 42 -2.99573227355399 NA -3.79796385825778 -3.23319203159013 -0.564771826667652 2.09882128207284 1.62795729159635 0.335072338032816 0.26909000375195 0.346920542438707 0.446560648658169 NA NA NA 0.550796186563489 99.311357293691 a5168 BRCA1_mut 193 GW-2580 CSF1R (cFMS) 4 44 2.99573227355399 NA 5.73777452300255 5.43844471703019 0.299329805972365 0.47104447028788 0.762179063005698 0.400891530608754 0.635459759859677 0.392728979974784 0.446618508254778 NA NA NA 0.309531983967095 99.311357293691 a5169 loss_cnaBRCA7_(FAS,PTEN) 1046 681640 WEE1, CHEK1 4 32 0.693147180559945 NA 2.24613070871695 2.68225290546145 -0.436122196744503 0.681648787775863 1.09829182566106 0.408320888249193 0.639804844614361 0.397091361835459 0.446653879681035 NA NA NA 0.314855039751892 99.311357293691 a5170 gain_cnaBRCA62 5 Sunitinib PDGFRA, PDGFRB, KDR, KIT, FLT3 4 8 2.07944154167984 NA 2.80260143478012 3.48180489447971 -0.67920345969959 1.6780070403125 1.26281517544785 0.485021143537104 0.404767943984967 0.537848667726626 0.446720887115645 NA NA NA 0.508224191926815 99.311357293691 a5171 BRCA2_mut 228 KIN001-102 AKT1 6 43 2.32630161961136 NA 1.53040492778961 2.00137317758809 -0.470968249798479 1.42266335362971 1.40669268288657 0.334399424825561 0.331046869659555 0.334805359783375 0.446728118196832 NA NA NA 0.473765658682203 99.311357293691 a5172 CDH1_mut 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 5 42 2.99573227355399 NA 4.31146075301 3.79244826543409 0.519012487575904 1.66693597424029 1.40400184837646 0.363114979271156 0.311357182037207 0.369666527274214 0.446765283986595 NA NA NA 0.535192442182908 99.311357293691 a5173 loss_cnaBRCA29_(MAP2K4) 1219 PFI-1 BRD2, BRD3, BRD4 7 40 2.30258509299405 NA 2.90509319133194 3.21927393988036 -0.314180748548417 0.855271313316349 1.01947727150484 0.314450045351256 0.367346295446492 0.308178276583505 0.446789338048292 NA NA NA 0.406391260139629 99.311357293691 a5174 gain_cnaBRCA31 110 Roscovitine CDKs 4 9 2.77258872223978 NA 4.41732924060478 3.93011051144129 0.487218729163489 0.946721128914955 1.05641234175859 0.47410573737294 0.514638064243791 0.461201284673015 0.446807031059044 NA NA NA 0.438184744911274 99.311357293691 a5175 gain_cnaBRCA8_(CHD4,WNK1) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 3 43 2.30258509299405 NA 1.83999549765049 1.38339673512023 0.456598762530259 0.783645985611953 1.00540989165286 0.458247974790276 0.58265948006318 0.454141904034411 0.44694784004156 NA NA NA 0.422673353332556 99.311357293691 a5176 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1009 ATRA Retinoic acid and retinoid X receptor agonist 15 30 2.30258509299405 NA 3.91845962145796 4.19972649664975 -0.28126687519179 1.34651403291835 1.05638085207905 0.242713025649958 0.208885216429708 0.266255181204989 0.44696309981611 NA NA NA 0.486429846225111 99.311357293691 a5177 gain_cnaBRCA19 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 4 42 2.30258509299405 NA 1.7784408976782 1.37838767886687 0.400053218811324 0.521590456150499 1.02252492701168 0.40149748400713 0.766987229336677 0.391240553890923 0.447008062826057 NA NA NA 0.241074866373618 99.311357293691 a5178 loss_cnaBRCA7_(FAS,PTEN) 1025 SB 216763 GSK3A, GSK3B 4 35 2.30258509299405 NA 5.17599151105296 4.85638074149484 0.319610769558123 0.338942175157017 0.815710975787514 0.405661108382014 0.942965476072906 0.391818645384243 0.447014681053477 NA NA NA 0.181741732054011 99.311357293691 a5179 loss_cnaBRCA24 173 FH535 unknown 3 45 3.46573590279973 NA 1.02369882217727 1.60961802006527 -0.585919197887999 1.19846558589341 1.28535252773281 0.45714318749773 0.488891132782271 0.455843191067187 0.447205011641672 NA NA NA 0.489822934710927 99.311357293691 a5180 gain_cnaBRCA47_(EGFR) 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 3 23 2.30258509299405 NA 4.26829751945662 4.74024754294462 -0.471950023488004 1.0609669246986 0.988880605343021 0.474280031555855 0.44483010026168 0.477256830539512 0.447282866519779 NA NA NA 0.528163146378826 99.311357293691 a5181 loss_cnaBRCA7_(FAS,PTEN) 1375 Temozolomide DNA akylating agent 4 42 3.40119738166216 NA 6.15612856796411 5.87574473231677 0.280383835647339 0.16000028426604 0.722758983228941 0.401159073767278 1.75239585937942 0.387935455875925 0.447388620746557 NA NA NA 0.0542250847176372 99.311357293691 a5182 gain_cnaBRCA27_(CLTC,PPM1D) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 9 38 0.940007258491471 NA 1.60037831743615 1.9569356349144 -0.356557317478248 1.12967644510231 1.28034309586357 0.284136420934972 0.315627823368448 0.278485757942683 0.447403351201857 NA NA NA 0.421621746283984 99.311357293691 a5183 PIK3CA_mut 298 OSI-930 KIT, VEGFR, PDGFR 16 32 2.32630161961136 NA 3.77653263463843 3.98178462734413 -0.205251992705695 1.05527121067999 0.772711831453709 0.234591022678588 0.194501650976942 0.265625533802883 0.447488511586041 NA NA NA 0.496458047013604 99.311357293691 a5184 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1010 Gefitinib EGFR 6 39 -0.693147180559945 NA 1.70371880705296 1.35315612354419 0.35056268350877 1.13985685511165 1.02961196899472 0.336100284782977 0.307549743581121 0.340480388792536 0.447609873588219 NA NA NA 0.502993128433958 99.311357293691 a5185 PIK3CA_mut 56 WH-4-023 SRC family, ABL 4 8 1.63315443905142 NA 3.58718673341402 3.04133309571351 0.545853637700511 0.969014207573638 1.1893241404411 0.484016108655999 0.563308188295093 0.458961202534798 0.447635478560905 NA NA NA 0.421459787996973 99.311357293691 a5186 loss_cnaBRCA38 1377 Afatinib (rescreen) ERBB2, EGFR 3 44 2.30258509299405 NA 3.6864350908394 2.77656320085474 0.909871889984662 1.54711094344113 2.00883242010273 0.457087241279972 0.588110305755382 0.452935685863797 0.447667153017528 NA NA NA 0.418946382621591 99.311357293691 a5187 gain_cnaBRCA16 171 AKT inhibitor VIII AKT1, AKT2, AKT3 16 31 0.940007258491471 NA 2.08380176401361 1.7879397019179 0.295862062095715 1.07406852011124 1.336159110238 0.235766859142575 0.27545920633171 0.221427268525688 0.447732049476846 NA NA NA 0.416626968139955 99.311357293691 a5188 gain_cnaBRCA14_(RAD21) 1143 HG-5-88-01 EGFR, ADCK4 13 13 2.30258509299405 NA 4.68248193780577 4.38567215689111 0.296809780914656 1.01775317576676 0.941750974376182 0.302716147742455 0.291632380013008 0.315168010430001 0.447779204565364 NA NA NA 0.447823995791453 99.311357293691 a5189 loss_cnaBRCA7_(FAS,PTEN) 1018 ABT-888 PARP1, PARP2 4 41 1.6094379124341 NA 4.15986295253723 4.42680431294727 -0.266941360410045 0.218931892271587 0.687131224208095 0.401266930562415 1.21928951346614 0.388486727142533 0.447839923875226 NA NA NA 0.110011064412285 99.311357293691 a5190 TP53_mut 1502 Bicalutamide ANDR (androgen receptor) 36 9 2.30258509299405 NA 4.59165544218814 4.42489389599218 0.166761546195954 0.582346554337807 0.592592426143257 0.285420410029026 0.286361351249996 0.281410188249081 0.44794143860794 NA NA NA 0.463050970063 99.311357293691 a5191 gain_cnaBRCA15 1371 PLX4720 (rescreen) BRAF 22 25 2.30258509299405 NA 4.82112672795184 4.60684548570543 0.214281242246412 0.763610076082776 1.09962539826907 0.223767877276561 0.280616048632632 0.194867490859808 0.447986025926699 NA NA NA 0.437869869171278 99.311357293691 a5192 gain_cnaBRCA64_(SDHC) 184 BMS-754807 IGF1R 8 40 0.940007258491471 NA 2.04185593722736 1.54387155817038 0.497984379056976 1.79307337870197 1.65969310059601 0.296300563406401 0.277726714908608 0.300046062056983 0.448152268667607 NA NA NA 0.485358274625182 99.311357293691 a5193 gain_cnaBRCA19 166 FTI-277 Farnesyl transferase (FNTA) 4 43 0.0237165266173161 NA 1.94580076339654 2.27216346522008 -0.326362701823544 0.821434150640897 0.815697685420268 0.3999144122713 0.397308416711079 0.400102522854891 0.448243368759441 NA NA NA 0.494021077103656 99.311357293691 a5194 loss_cnaBRCA60 228 KIN001-102 AKT1 3 46 2.32630161961136 NA 2.54616010163269 1.90441295430712 0.641747147325572 0.0861219959004535 1.43930531804468 0.455637161802349 7.45160560453515 0.445872838292153 0.448304460222031 NA NA NA 0.00502225674785001 99.311357293691 a5195 loss_cnaBRCA17 1039 SL 0101-1 RSK, AURKB, PIM3 6 37 2.30258509299405 NA 4.92871458271081 4.60344140398474 0.325273178726063 0.34717547913442 1.02233693830708 0.336856103628011 0.936912882030251 0.318166317324593 0.448419049420589 NA NA NA 0.152748451586321 99.311357293691 a5196 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 167 OSU-03012 PDPK1 (PDK1) 9 39 2.77258872223978 NA 2.52022435358149 2.18515318312342 0.335071170458072 1.01437192539348 1.21851607618807 0.282631548916139 0.330323781711621 0.274982970685367 0.448602165897163 NA NA NA 0.405286827777728 99.311357293691 a5197 gain_cnaBRCA63 127 GSK269962A ROCK1, ROCK2 3 11 0.916290731874155 NA 2.91347783172291 2.34660127288497 0.566876558837942 0.452367421251854 1.20058302962405 0.510043399208832 1.25313303347355 0.472167725888525 0.448765401066467 NA NA NA 0.233369446476828 99.311357293691 a5198 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 203 BMS-345541 IKBKB 6 43 2.77258872223978 NA 3.23745017051222 3.57347846751999 -0.336028297007773 0.525155448933354 1.05235165878739 0.332885710429056 0.639864439548865 0.319311794875652 0.448775540028661 NA NA NA 0.233984668166433 99.311357293691 a5199 gain_cnaBRCA14_(RAD21) 59 WZ-1-84 BMX 6 6 2.32630161961136 NA 3.28637457639762 3.83741948512585 -0.551044908728228 1.37095366119467 1.02599117147633 0.455100469796651 0.40194276752435 0.537085429239428 0.448828675683565 NA NA NA 0.4502466753985 99.311357293691 a5200 gain_cnaBRCA9_(KRAS) 1529 MLN4924 NEDD8-activating enzyme 4 33 0 NA 0.984821623756429 0.294596320664069 0.69022530309236 0.599782530821111 1.77059894528846 0.405514309284376 1.15079260835995 0.389825886279351 0.448849556799852 NA NA NA 0.135616973320625 99.311357293691 a5201 loss_cnaBRCA57 1378 Bleomycin (50 uM) DNA damage 5 43 3.91202300542815 NA 4.42314169892603 3.74173806831536 0.681403630610667 2.02193969811778 1.87516492782252 0.360840145205638 0.337004922176949 0.363383305916418 0.448955207508757 NA NA NA 0.505658997083991 99.311357293691 a5202 loss_cnaBRCA17 1261 rTRAIL TR10A (DR4), TR10B (DR5) 9 38 -2.30258509299405 NA -0.378318977248952 -0.0843053290357451 -0.294013648213207 1.04815840797874 1.03640665082605 0.283112249281661 0.280504975178495 0.283685605431872 0.449031786525591 NA NA NA 0.462918272782762 99.311357293691 a5203 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 257 NPK76-II-72-1 PLK3 15 34 2.32630161961136 NA 3.73944030437497 3.36404264678617 0.3753976575888 1.22290354905418 1.71790326354681 0.236591958502307 0.30697241649118 0.218520836157996 0.449107630724988 NA NA NA 0.390295190484289 99.311357293691 a5204 loss_cnaBRCA24 345 KIN001-270 CDK9 3 46 2.99573227355399 NA 4.81252523222716 5.12683014617336 -0.314304913946198 0.271351271617161 0.704032195441786 0.454749636892656 1.15829534194938 0.446435427216463 0.449183558770876 NA NA NA 0.167905011233705 99.311357293691 a5205 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1050 ZM-447439 AURKB 16 23 1.38629436111989 0.693147180559945 3.08158913926835 2.75320056315263 0.328388576115723 1.39657713218645 1.26350659388001 0.248954040693235 0.235138159251974 0.259902542421484 0.44927977063153 NA NA NA 0.458580909137691 99.311357293691 a5206 gain_cnaBRCA19 153 Midostaurin KIT 4 43 -0.669430653942629 NA 0.0802200379238694 0.661669090282662 -0.581449052358793 1.55728972159858 1.45003906358818 0.39895376728882 0.373372433076825 0.400988543660317 0.449327382265013 NA NA NA 0.517532100181785 99.311357293691 a5207 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1199 Tamoxifen ER 6 41 1.6094379124341 NA 4.14689088721819 3.82852817376775 0.318362713450439 1.20470635244579 0.918259803155364 0.333593782069163 0.264265821130684 0.346702221262944 0.449328723753815 NA NA NA 0.557615099938432 99.311357293691 a5208 CDH1_mut 1264 SGC0946 Q8TEK3 (DOT1L) 5 41 -0.693147180559945 NA 2.14657866365532 1.9268276876706 0.219750975984726 0.749012885304078 0.591780781052884 0.36157655098134 0.293387444056471 0.371338480431469 0.449354822231118 NA NA NA 0.557026427033836 99.311357293691 a5209 gain_cnaBRCA13_(FGFR1,WHSC1L1) 94 TGX221 PI3Kbeta 4 10 2.30258509299405 NA 3.34479011382344 3.93891976102745 -0.594129647204011 1.59806354913568 1.16091906517873 0.4626342370676 0.371780989263757 0.511775252060782 0.449372996055162 NA NA NA 0.533588969945588 99.311357293691 a5210 gain_cnaBRCA14_(RAD21) 272 AR-42 HDAC 21 28 1.63315443905142 NA -0.0507714270052646 0.286523655793649 -0.337295082798913 1.74293073721785 1.35465506668717 0.220173027440042 0.193521793836351 0.248989644001239 0.449452435597628 NA NA NA 0.466598738307956 99.311357293691 a5211 gain_cnaBRCA62 226 GSK1070916 AURKB 10 39 0.940007258491471 2.32630161961136 1.98436091767529 2.51153406601283 -0.527173148337545 2.90644699742689 1.64431654893335 0.270305179644412 0.181380616541178 0.320603200569571 0.44952101810286 NA NA NA 0.592879426403479 99.311357293691 a5212 gain_cnaBRCA10_(MDM2,NUP107) 1032 Afatinib ERBB2, EGFR 3 42 -0.693147180559945 NA 1.07114289047617 0.234709470389352 0.836433420086814 1.2040200411619 1.85959046119841 0.455995593040064 0.694700579302353 0.449794423847375 0.449613549459784 NA NA NA 0.354138629850621 99.311357293691 a5213 loss_cnaBRCA18 268 YM155 BIRC5 (Survivin) 16 33 1.63315443905142 NA -3.8458749078797 -3.47422192638753 -0.371652981492167 1.63929677390636 1.58165969202702 0.23224246211126 0.226714886168254 0.234976577683322 0.449653887543683 NA NA NA 0.457697785191952 99.311357293691 a5214 gain_cnaBRCA27_(CLTC,PPM1D) 1054 PD-0332991 CDK4, CDK6 10 32 1.38629436111989 0.693147180559945 3.19219159031078 2.78625259706727 0.405938993243513 1.55721931692844 1.4406352476677 0.276586562806473 0.260681966137058 0.281777774006782 0.449673902541025 NA NA NA 0.47597453596001 99.311357293691 a5215 loss_cnaBRCA7_(FAS,PTEN) 1495 AZD-2281 PARP1, PARP2 4 41 2.30258509299405 NA 4.41052997047015 3.95851191417339 0.452018056296766 0.511309865461577 1.16469936192274 0.399512065405154 0.884039379699262 0.388098483672691 0.449814757840453 NA NA NA 0.194877157196836 99.311357293691 a5216 gain_cnaBRCA62 344 THZ-2-49 CDK9 10 39 2.99573227355399 NA 2.10248480185815 1.70393914755913 0.398545654299022 1.45293541777022 1.48103075844703 0.270073699905324 0.274303764244842 0.269100187167569 0.449906951078748 NA NA NA 0.453463358230427 99.311357293691 a5217 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1375 Temozolomide DNA akylating agent 8 38 3.40119738166216 NA 6.07134981153194 5.86407880360277 0.207271007929171 0.227975128027379 0.755766876654714 0.296530862547529 0.909182548651879 0.274252569584187 0.449946353328145 NA NA NA 0.165852476644664 99.311357293691 a5218 loss_cnaBRCA28_(GPS2) 1036 PLX4720 BRAF 3 40 2.30258509299405 NA 5.10779689610102 4.55827708799243 0.549519808108591 0.47912745656436 1.22972740365773 0.456404811840158 1.1469177993868 0.446863106794309 0.450160798068198 NA NA NA 0.172809044508843 99.311357293691 a5219 loss_cnaBRCA34 274 PXD101, Belinostat HDAC 5 43 2.99573227355399 NA 0.1886965636618 0.727643669489596 -0.538947105827795 0.553097821030727 1.55803396900744 0.359859328244896 0.974415528926581 0.345914862287075 0.450181321560553 NA NA NA 0.138938202074459 99.311357293691 a5220 loss_cnaBRCA57 1033 Vismodegib SMO 5 40 2.30258509299405 NA 5.01149475743399 4.72830954621287 0.283185211221124 0.843207715624528 0.777078024714743 0.361452222365025 0.3358427656362 0.364423136692198 0.450214719374404 NA NA NA 0.50784242354349 99.311357293691 a5221 loss_cnaBRCA17 222 BX-912 PDPK1 (PDK1) 11 38 2.32630161961136 NA 3.57784395822579 3.97234143876676 -0.394497480540975 1.10787496035534 1.60584368487219 0.260622240025082 0.356084842295239 0.245663687105619 0.450337230699531 NA NA NA 0.361171295397473 99.311357293691 a5222 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 8 35 1.6094379124341 NA 2.95754895534777 2.47815109878956 0.479397856558207 1.24199365280152 1.67079000316445 0.298558628711075 0.385990584957376 0.286928851411748 0.450504859667698 NA NA NA 0.374597754368195 99.311357293691 a5223 gain_cnaBRCA8_(CHD4,WNK1) 274 PXD101, Belinostat HDAC 4 44 2.99573227355399 NA 0.126094758005735 0.721085944871334 -0.594991186865599 1.13638157023354 1.51968705925662 0.397274669490237 0.523583981341164 0.391522177701932 0.45070448873277 NA NA NA 0.385849075099857 99.311357293691 a5224 loss_cnaBRCA29_(MAP2K4) 304 SB52334 ALK5 7 42 2.99573227355399 NA 3.96262852794059 4.35843561780073 -0.395807089860141 0.851289308529834 1.32570762123879 0.310434262803476 0.464950147845384 0.298562883337946 0.450810152825616 NA NA NA 0.320457800186695 99.311357293691 a5225 gain_cnaBRCA47_(EGFR) 1059 AZD8055 MTORC1/2 6 37 0.693147180559945 NA 0.421256012466421 0.083269877624876 0.337986134841545 0.490277447536391 1.06137861001488 0.334909525911468 0.689377283291126 0.318440688037614 0.451027334585019 NA NA NA 0.223323882274466 99.311357293691 a5226 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 261 TL-1-85 MAP3K7 (TAK1) 6 43 2.32630161961136 NA 3.67217979910379 4.07401018689697 -0.401830387793181 1.35024755851518 1.19618735007043 0.331131558906286 0.297597566652933 0.335925963244404 0.451155035547125 NA NA NA 0.514185423394642 99.311357293691 a5227 loss_cnaBRCA18 341 EX-527 SIRT1 16 33 2.99573227355399 NA 5.53970581534676 5.6912307774324 -0.151524962085636 0.612622040290445 0.674540438628569 0.231189309595257 0.247338411157715 0.224634363498958 0.451699472393297 NA NA NA 0.438044420598568 99.311357293691 a5228 loss_cnaBRCA28_(GPS2) 1059 AZD8055 MTORC1/2 3 40 0.693147180559945 NA -0.296414998131271 0.162444163532819 -0.45885916166409 1.70828194240699 0.959733839605574 0.454670387727524 0.268608565291952 0.478110849829646 0.451872333100026 NA NA NA 0.688954895847485 99.311357293691 a5229 MLL3_mut 151 QS11 ARFGAP 3 45 2.32630161961136 NA 3.13160502517367 3.80237288392772 -0.670767858754051 1.71428205890039 1.47139807691124 0.452370040985832 0.391282085273826 0.45587109924877 0.451933185625963 NA NA NA 0.57072626332057 99.311357293691 a5230 gain_cnaBRCA14_(RAD21) 294 MPS-1-IN-1 MPS1 21 28 2.99573227355399 NA 4.60964888800444 4.8666693141665 -0.257020426162063 1.30590095378813 1.06566428055925 0.21894254930761 0.196814640050996 0.241183298390353 0.451974710189556 NA NA NA 0.465924090909254 99.311357293691 a5231 gain_cnaBRCA12_(TERT) 1371 PLX4720 (rescreen) BRAF 10 37 2.30258509299405 NA 4.50330456554059 4.76223998654515 -0.25893542100455 0.693482839466172 1.01306143125132 0.270367864132047 0.373384035290438 0.25559695889786 0.452053034418861 NA NA NA 0.357923480857076 99.311357293691 a5232 gain_cnaBRCA12_(TERT) 1230 IOX2 EGLN1 10 37 -2.30258509299405 NA 0.38879680299936 0.211804849960612 0.176991953038747 0.492995471113282 0.689241868421662 0.270334141032136 0.359013344765752 0.25679222512128 0.452109087103142 NA NA NA 0.369568982091348 99.311357293691 a5233 PIK3CA_mut 1021 Axitinib PDGFR, KIT, VEGFR 16 29 0.693147180559945 NA 2.64083926369952 2.36387605202886 0.276963211670664 1.39596931093889 1.03233059176751 0.236303484489864 0.198402077682056 0.268289261094606 0.452116278200704 NA NA NA 0.493308597337273 99.311357293691 a5234 gain_cnaBRCA15 1021 Axitinib PDGFR, KIT, VEGFR 21 24 0.693147180559945 NA 2.60404511714661 2.3383702611646 0.265674855982003 1.28651437589004 1.06258034280046 0.226671515728961 0.206507491063365 0.250028016970283 0.45223718641891 NA NA NA 0.458435674403178 99.311357293691 a5235 ASH1L_mut 1264 SGC0946 Q8TEK3 (DOT1L) 3 43 -0.693147180559945 NA 1.69348074379068 1.96866014607905 -0.275179402288366 0.358730774011049 0.617169757608821 0.452738331024713 0.767091708390455 0.445873114966826 0.452394676885885 NA NA NA 0.315585410439046 99.311357293691 a5236 gain_cnaBRCA12_(TERT) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 10 36 2.30258509299405 NA 1.20183210250674 1.47188125216817 -0.270049149661426 0.983318062253802 0.999936572956445 0.270981358680251 0.274630518880599 0.270066279167078 0.452447891827056 NA NA NA 0.456196433923539 99.311357293691 a5237 NF1_mut 175 PAC-1 CASP3 agonist 5 43 0.940007258491471 NA 2.00881764417877 2.44702879547059 -0.438211151291826 1.47193033832277 1.19806191360918 0.357924721887404 0.297711882065802 0.365766698961082 0.452605498939157 NA NA NA 0.5515740169117 99.311357293691 a5238 gain_cnaBRCA31 303 PIK-93 PI4K, PI3K 16 33 2.99573227355399 NA 3.01276599736307 2.68425990381524 0.328506093547832 1.45089586745654 1.41095904436288 0.23072058456166 0.226416037784787 0.23282468393416 0.452611641924014 NA NA NA 0.45933903765565 99.311357293691 a5239 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 271 VNLG/124 HDAC, RAR 6 43 1.63315443905142 NA 3.91572507606163 4.18433057487288 -0.268605498811247 1.19107402735584 0.757043073500796 0.329865310868608 0.225515369021644 0.35480873970504 0.452877263830951 NA NA NA 0.611701879981864 99.311357293691 a5240 loss_cnaBRCA57 1042 BIRB 0796 p38, JNK2 5 38 2.30258509299405 NA 4.66132940568704 4.32781478472994 0.333514620957099 0.603260015282081 0.953541367950878 0.360469079040089 0.552853848271628 0.349764186606616 0.452949973894585 NA NA NA 0.319189684295586 99.311357293691 a5241 loss_cnaBRCA57 1024 CEP-701 FLT3, JAK2, NTRK1, RET 5 40 0.693147180559945 NA 1.08470382322996 0.568177059746424 0.516526763483534 1.1351511599218 1.46532467388377 0.359244775317178 0.45502905843757 0.352499874389275 0.452967893132974 NA NA NA 0.391439734635373 99.311357293691 a5242 POLR2B_mut 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 3 42 -0.669430653942629 NA -4.51463609684387 -3.41273116117994 -1.10190493566394 1.4868782366788 2.47153770810336 0.452604582918334 0.741086195548354 0.44583780051227 0.452969173468968 NA NA NA 0.329098601557172 99.311357293691 a5243 loss_cnaBRCA18 1371 PLX4720 (rescreen) BRAF 15 32 2.30258509299405 NA 4.86157819409318 4.63475788269308 0.226820311400099 0.652719533313235 1.06729431844285 0.236827931027681 0.347500419129098 0.212518990760695 0.453089730109379 NA NA NA 0.375102150693383 99.311357293691 a5244 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 163 JQ1 BRD4 6 41 0.940007258491471 NA -0.105237912824493 0.377549133473393 -0.482787046297885 1.60378296423606 1.4413521427213 0.330609822878741 0.301030162474543 0.334954264116452 0.453369038524803 NA NA NA 0.510737750738764 99.311357293691 a5245 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 223 ZSTK474 PI3K 6 43 1.63315443905142 2.32630161961136 1.33139152508906 0.853865371040923 0.477526154048136 1.19132799066493 1.47738907685063 0.329409549422212 0.400835166964901 0.323223016557077 0.453498083187621 NA NA NA 0.401258819091615 99.311357293691 a5246 gain_cnaBRCA27_(CLTC,PPM1D) 238 CAL-101 PI3Kdelta 9 40 2.99573227355399 2.32630161961136 4.93437182154599 4.67049750895638 0.263874312589615 0.722874041617278 0.986420328016571 0.278714014007731 0.365034981750419 0.267506969488551 0.453741965858266 NA NA NA 0.371968511819362 99.311357293691 a5247 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1371 PLX4720 (rescreen) BRAF 18 29 2.30258509299405 NA 4.84113063116643 4.62398530333036 0.217145327836066 0.759351922966682 1.06026448590909 0.226721318599285 0.285961385318825 0.204802981446542 0.453839872107345 NA NA NA 0.418848359327408 99.311357293691 a5248 BRCA1_mut 133 Doxorubicin DNA intercalating 4 44 0.0237165266173161 NA -0.366350268190808 -1.0910354122015 0.724685144010693 1.39494496745126 1.8646695685532 0.39434380903702 0.519508052948343 0.388639980097374 0.454031470689172 NA NA NA 0.389192108354231 99.311357293691 a5249 loss_cnaBRCA57 1005 Cisplatin DNA crosslinker 5 40 1.79175946922805 2.30258509299405 4.04738924414739 3.622920340016 0.424468904131396 1.25654325606314 1.17675391181511 0.358382174476888 0.337806837992425 0.360711700101057 0.454046415451006 NA NA NA 0.505923227822451 99.311357293691 a5250 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1218 JQ1 BRD2, BRD3, BRD4 18 28 0 NA 2.36033868489826 2.52075249229171 -0.160413807393458 0.759482809977851 0.665135809268221 0.228155288437159 0.211214533477244 0.241174516780182 0.454147633433994 NA NA NA 0.468533640247208 99.311357293691 a5251 gain_cnaBRCA19 175 PAC-1 CASP3 agonist 4 44 0.940007258491471 NA 1.95898869946995 2.44159935518749 -0.482610655717539 1.43643343781745 1.20818147727381 0.394172134645276 0.335978433118927 0.399452122711335 0.454226790298885 NA NA NA 0.556225204564115 99.311357293691 a5252 gain_cnaBRCA16 298 OSI-930 KIT, VEGFR, PDGFR 16 32 2.32630161961136 NA 4.04819154280632 3.84595517326018 0.20223636954614 0.924067013501697 0.85039195104689 0.231101334383543 0.218854657282676 0.237815479435304 0.454231767740033 NA NA NA 0.469211545854396 99.311357293691 a5253 gain_cnaBRCA64_(SDHC) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 9 36 2.30258509299405 NA 1.61388483921248 1.30318380936038 0.310701029852101 1.20203812120133 1.08026170058606 0.28144856826633 0.258478516090309 0.287616444870294 0.454242413341036 NA NA NA 0.493519234739801 99.311357293691 a5254 gain_cnaBRCA62 37 Crizotinib MET, ALK 5 9 0.693147180559945 NA 2.43444020688949 2.77332152413621 -0.338881317246718 0.884356602023936 0.731237115623024 0.431366243741988 0.383195326942949 0.463435607966898 0.45426785931431 NA NA NA 0.489078900575196 99.311357293691 a5255 gain_cnaBRCA62 150 Bicalutamide ANDR (androgen receptor) 9 39 0.0237165266173161 NA 2.62103567225144 2.79525360603761 -0.17421793378617 0.897926797671912 0.549644758380182 0.279047130528394 0.194022423919045 0.316964605101657 0.454341557974827 NA NA NA 0.58956831261181 99.311357293691 a5256 gain_cnaBRCA30_(CRNKL1,FOXA2) 276 CAY10603 HDAC6 5 44 2.99573227355399 NA 1.49302811793562 1.13946152124031 0.353566596695309 1.58176035559796 0.91944644483672 0.356001493390491 0.223527284296899 0.384542893912757 0.454410232862429 NA NA NA 0.647703158887299 99.311357293691 a5257 gain_cnaBRCA47_(EGFR) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 7 40 -2.30258509299405 NA -0.413897302066198 -0.0927798046033875 -0.32111749746281 0.94877901652066 1.05180967040808 0.309164303717793 0.338453414200079 0.305300004836638 0.454417413561305 NA NA NA 0.43801932980731 99.311357293691 a5258 gain_cnaBRCA8_(CHD4,WNK1) 1052 RO-3306 CDK1 3 40 1.6094379124341 NA 3.01972936182351 3.56361916056462 -0.543889798741107 0.520630217281622 1.22792760572554 0.452069377628963 1.04467581920414 0.442933114464627 0.454446155504377 NA NA NA 0.203484107607868 99.311357293691 a5259 gain_cnaBRCA12_(TERT) 1061 SB590885 BRAF 9 33 1.6094379124341 NA 4.25501375923364 3.94561113382785 0.309402625405792 0.804690802903084 1.14992221185744 0.283943780851079 0.384498771813422 0.269063961210056 0.454631434894279 NA NA NA 0.367485424204292 99.311357293691 a5260 gain_cnaBRCA19 271 VNLG/124 HDAC, RAR 4 45 1.63315443905142 NA 3.85729413318831 4.17758641429223 -0.320292281103916 1.4731272787227 0.748586655753141 0.393320942438518 0.21742335895214 0.427862664452221 0.454699182865221 NA NA NA 0.695054426465693 99.311357293691 a5261 gain_cnaBRCA63 134 Etoposide TOP2 6 41 2.77258872223978 NA 3.0984998193725 2.38616538631389 0.712334433058617 2.80088655254099 2.06854883513182 0.329448361113722 0.254324628897369 0.34436432969842 0.454947383498217 NA NA NA 0.571402599361144 99.311357293691 a5262 gain_cnaBRCA13_(FGFR1,WHSC1L1) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 10 36 1.63315443905142 NA 1.60036066999957 2.02999339155116 -0.429632721551598 2.05359432071741 1.45324854965886 0.269439553237345 0.20921012354646 0.295636091742498 0.45500760301074 NA NA NA 0.547306363732908 99.311357293691 a5263 gain_cnaBRCA48 1529 MLN4924 NEDD8-activating enzyme 4 33 0 NA -0.238014062328392 0.44281882806829 -0.680832890396682 1.37481237612063 1.7300243094005 0.399905589456484 0.49521876746398 0.393539493460996 0.455097242168721 NA NA NA 0.412813641148368 99.311357293691 a5264 gain_cnaBRCA10_(MDM2,NUP107) 228 KIN001-102 AKT1 5 44 2.32630161961136 NA 2.39332607114311 1.89261013289341 0.500715938249706 1.0541974979737 1.43725921345447 0.355440531906395 0.474973559709772 0.34838248630616 0.455117266032832 NA NA NA 0.372745841374441 99.311357293691 a5265 gain_cnaBRCA48 1039 SL 0101-1 RSK, AURKB, PIM3 4 39 2.30258509299405 NA 4.99559184881792 4.61326287303663 0.382328975781293 0.663341785483486 0.985750240855473 0.395861199946689 0.576367996330319 0.387855827911838 0.455158321021455 NA NA NA 0.350651992127919 99.311357293691 a5266 loss_cnaBRCA28_(GPS2) 256 JW-7-24-1 LCK 4 44 2.32630161961136 NA 1.41741707870719 1.87576476954263 -0.458347690835435 0.494421588802054 1.19836172392717 0.393267583534522 0.927038182021898 0.382478580284906 0.455256735579927 NA NA NA 0.178543735478514 99.311357293691 a5267 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 300 CX-5461 RNA Pol I 6 43 2.32630161961136 NA 3.41994353943421 3.9810753053804 -0.56113176594619 2.35079802539856 1.6173629120309 0.32806990485248 0.238698416403109 0.346942397264188 0.45532575847788 NA NA NA 0.592850916280006 99.311357293691 a5268 gain_cnaBRCA10_(MDM2,NUP107) 256 JW-7-24-1 LCK 5 43 2.32630161961136 NA 1.46614336830804 1.8807581705387 -0.414614802230664 0.440502451544109 1.21212665925237 0.355743380890985 0.941231543155548 0.342055674682047 0.455347963783287 NA NA NA 0.148497841671035 99.311357293691 a5269 gain_cnaBRCA12_(TERT) 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 5 21 2.30258509299405 NA 2.31497405350496 2.78120178338008 -0.466227729875116 1.13427053084451 1.25408743576447 0.377535102625404 0.411037505777382 0.371766526463055 0.455423908303208 NA NA NA 0.446927918788429 99.311357293691 a5270 gain_cnaBRCA10_(MDM2,NUP107) 345 KIN001-270 CDK9 5 44 2.99573227355399 NA 5.32797921178583 5.08254241731198 0.245436794473859 0.420098062304852 0.711268923763998 0.355047008239089 0.584236911561266 0.345068913140504 0.455613642768437 NA NA NA 0.29409332638027 99.311357293691 a5271 gain_cnaBRCA9_(KRAS) 194 AUY922 HSP90 4 43 -1.36257783450257 NA -3.0164338117318 -2.33582272719253 -0.680611084539262 1.09942918919852 1.76656188301293 0.393392202558115 0.619058590790575 0.385274408490269 0.455633307604079 NA NA NA 0.320987200039515 99.311357293691 a5272 loss_cnaBRCA17 1143 HG-5-88-01 EGFR, ADCK4 4 22 2.30258509299405 NA 4.8760364367683 4.47190261290846 0.404133823859842 0.983528673922192 0.98053547114584 0.411998831710277 0.4109019234266 0.412156251101836 0.455849161665718 NA NA NA 0.490016517006774 99.311357293691 a5273 loss_cnaBRCA36_(FAT1,IRF2) 1049 PD-173074 FGFR1, FGFR3 9 34 0.693147180559945 NA 2.68246289937938 3.00534369033094 -0.322880790951556 1.64514883632116 0.985681734940442 0.282092074548905 0.196262358652956 0.327571039927067 0.456038106783114 NA NA NA 0.586601271813036 99.311357293691 a5274 gain_cnaBRCA31 164 JQ12 HDAC 16 31 1.63315443905142 NA 1.32697374599488 1.70738481017866 -0.380411064183789 1.96422618847276 1.45753202351867 0.231411062718987 0.193669683469381 0.260996710909602 0.456112735699634 NA NA NA 0.500831391012655 99.311357293691 a5275 gain_cnaBRCA8_(CHD4,WNK1) 1005 Cisplatin DNA crosslinker 3 42 1.79175946922805 2.30258509299405 4.16676490793517 3.63460631184694 0.532158596088232 1.14820559398932 1.18622094705521 0.449276193248875 0.463469781782986 0.448616758462507 0.456277022191007 NA NA NA 0.510232939344049 99.311357293691 a5276 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1008 Methotrexate Dihydrofolate reductase (DHFR) 17 28 -1.6094379124341 NA 0.839593121630413 0.587363224373813 0.2522298972566 1.06462861378143 1.10679290967522 0.231129147284129 0.236918202264647 0.227892585009978 0.456318733264551 NA NA NA 0.452911772884291 99.311357293691 a5277 BRCA2_mut 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 5 38 0.693147180559945 NA 3.21103603760281 2.86860062192567 0.342435415677136 0.778184450103358 0.974748097931114 0.357691139407036 0.440044022508615 0.351306574902736 0.456415725135324 NA NA NA 0.406011099159947 99.311357293691 a5278 gain_cnaBRCA16 176 IPA-3 PAK1, PAK2, PAK3 16 31 3.46573590279973 NA 4.72734459738372 4.37786905135589 0.349475546027826 1.4873415921795 1.52373231992103 0.231180578769588 0.234966565760941 0.229354947361055 0.456558720560936 NA NA NA 0.454778539264977 99.311357293691 a5279 loss_cnaBRCA7_(FAS,PTEN) 1248 FK866 NAMPT 4 40 0 NA 0.323029357717798 -0.7480793931745 1.0711087508923 2.57236469604072 2.7291439772163 0.39404417627759 0.416390705618416 0.392470591450737 0.456594310218394 NA NA NA 0.477190539398573 99.311357293691 a5280 gain_cnaBRCA15 203 BMS-345541 IKBKB 22 27 2.77258872223978 NA 3.41239069354398 3.63006221735057 -0.217671523806593 1.07687623516031 0.951897670249839 0.215590456381127 0.20213234975344 0.228671138305719 0.456618320877312 NA NA NA 0.462729056399894 99.311357293691 a5281 ASH1L_mut 1218 JQ1 BRD2, BRD3, BRD4 3 43 0 NA 2.16341104602707 2.47853332498268 -0.315122278955617 0.700658979801642 0.703264648101903 0.448160256298097 0.449751288486773 0.448084913419329 0.456949935029013 NA NA NA 0.521219686113272 99.311357293691 a5282 gain_cnaBRCA12_(TERT) 341 EX-527 SIRT1 9 40 2.99573227355399 NA 5.49368999576478 5.67506746847336 -0.181377472708578 0.648525718954156 0.656930722369731 0.27669770209077 0.279676607122192 0.276098325945694 0.456995376193536 NA NA NA 0.464094478228804 99.311357293691 a5283 gain_cnaBRCA12_(TERT) 153 Midostaurin KIT 9 38 -0.669430653942629 NA 0.939980290023172 0.534548116411616 0.405432173611556 1.29842444014016 1.48995838248626 0.278122199513668 0.312249339336057 0.272109730296641 0.457015540329248 NA NA NA 0.427654710907651 99.311357293691 a5284 ARID1A_mut 281 CH5424802 ALK 5 43 1.63315443905142 NA 3.91381906342569 3.53586992402657 0.377949139399119 0.316585454382175 1.11190590125966 0.354363927890642 1.19382976750052 0.339911083276873 0.457087240652771 NA NA NA 0.102698054122566 99.311357293691 a5285 loss_cnaBRCA29_(MAP2K4) 1022 AZD7762 CHEK1, CHEK2 6 39 0.693147180559945 NA 1.36826661260059 0.833440543005774 0.53482606959482 1.71221184523166 1.61349621296559 0.329066455295335 0.312359753312219 0.331470297418186 0.457108277820437 NA NA NA 0.498145130707655 99.311357293691 a5286 loss_cnaBRCA36_(FAT1,IRF2) 271 VNLG/124 HDAC, RAR 9 40 1.63315443905142 NA 3.96773444572834 4.19277387910871 -0.225039433380366 0.766103200247547 0.823945912176681 0.276328648326277 0.293745585852729 0.273124036486646 0.457592322391583 NA NA NA 0.447047425383649 99.311357293691 a5287 MLL3_mut 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 3 43 2.30258509299405 NA 1.83012645110869 1.38408527325106 0.446041177857635 0.870698912571575 1.00231106241638 0.447515388761068 0.512279470454684 0.445012725672524 0.457593723941416 NA NA NA 0.47254976660454 99.311357293691 a5288 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 153 Midostaurin KIT 5 42 -0.669430653942629 NA 0.150539762231913 0.667141719587866 -0.516601957355953 0.864350738141371 1.50318045921665 0.354376717374938 0.597676307267131 0.343672613749362 0.457709310323356 NA NA NA 0.287949254850828 99.311357293691 a5289 ARID1A_mut 1091 BMS-536924 IGF1R 5 42 1.38629436111989 NA 2.67622967885536 3.06462037875866 -0.388390699903294 0.865028242764867 1.11613808137429 0.354322874080444 0.448991929629825 0.347977285592722 0.457777223880342 NA NA NA 0.396062667627861 99.311357293691 a5290 gain_cnaBRCA47_(EGFR) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 6 40 1.63315443905142 NA 1.48190759842556 2.0047980801321 -0.522890481706543 1.5976011352848 1.59429479067405 0.327898687961599 0.327297264728927 0.327976033519794 0.457858723577537 NA NA NA 0.480420008706383 99.311357293691 a5291 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 309 Y-39983 ROCK 6 43 2.99573227355399 NA 4.62448472357847 4.97830597892751 -0.353821255349049 1.10245155245066 1.08286536964774 0.326112814979165 0.320940411905206 0.326745378757607 0.458003492457734 NA NA NA 0.486576884777993 99.311357293691 a5292 gain_cnaBRCA64_(SDHC) 286 KIN001-236 TIE2 8 41 2.32630161961136 NA 4.35428388733799 4.5763615721424 -0.22207768480441 1.15442366790705 0.678320444804823 0.289101737921189 0.192371042779323 0.32739347089606 0.458199108678911 NA NA NA 0.61277259065919 99.311357293691 a5293 gain_cnaBRCA58_(CCND1) 192 LFM-A13 BTK 9 39 2.77258872223978 NA 4.98384183074716 4.75199973045774 0.231842100289412 0.626015375152371 0.876162070132528 0.27664829896507 0.370345696753825 0.264610975746009 0.458206346661081 NA NA NA 0.370071058286738 99.311357293691 a5294 gain_cnaBRCA9_(KRAS) 1248 FK866 NAMPT 4 40 0 NA 0.31923243123721 -0.747699700526441 1.06693213176365 1.51279044747748 2.78962774190214 0.39248712972241 0.705274239100809 0.382463981031444 0.458363565512308 NA NA NA 0.274113794829821 99.311357293691 a5295 loss_cnaBRCA42 228 KIN001-102 AKT1 3 46 2.32630161961136 NA 2.53291440084013 1.90527680435881 0.627637596481322 0.101984925588918 1.43964860490799 0.445498961052092 6.15421929130201 0.435965828287267 0.458406303830597 NA NA NA 0.00653130060891509 99.311357293691 a5296 loss_cnaBRCA18 63 BMS-509744 ITK 5 7 2.32630161961136 NA 3.88298991883041 3.3912906626644 0.491699256166005 0.764699864137257 1.25972545355224 0.451489669092059 0.642996395351456 0.390322553838604 0.45849949890831 NA NA NA 0.421484119716189 99.311357293691 a5297 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 293 MP470 PDGFR 7 41 2.99573227355399 NA 3.09504168883673 3.60611699026268 -0.511075301425948 1.71954207537998 1.66493951430375 0.305637304258613 0.297215932510992 0.306963284272624 0.458653014649049 NA NA NA 0.486047826512135 99.311357293691 a5298 gain_cnaBRCA62 104 Bortezomib Proteasome 5 9 -3.91202300542815 NA -5.05934806880292 -4.30102916085004 -0.758318907952885 1.0627091450343 2.04148273583086 0.426933403404367 0.71357145226073 0.371454969784135 0.458809314070729 NA NA NA 0.37891539734517 99.311357293691 a5299 gain_cnaBRCA12_(TERT) 1161 ZG-10 IRAK1 5 21 2.30258509299405 NA 1.55004386272487 2.07668839067717 -0.526644527952301 1.01917635354026 1.47102288970995 0.374612856232613 0.516735426722691 0.358012463052931 0.45887980246068 NA NA NA 0.370800857788564 99.311357293691 a5300 loss_cnaBRCA7_(FAS,PTEN) 1031 Elesclomol HSP70 4 40 -1.6094379124341 NA -2.34033773299705 -3.04130320432811 0.700965471331065 1.4563600552711 1.81125667519786 0.391985310030671 0.481313304902875 0.387005045132265 0.458934625536837 NA NA NA 0.421068531535182 99.311357293691 a5301 PIK3CA_mut 83 JW-7-52-1 MTOR 4 8 0.182321556793955 NA -1.32877472410198 -2.36548562018931 1.03671089608733 3.18937442020342 1.59413759197054 0.47169415541138 0.325051486435766 0.650327111856032 0.458948296611816 NA NA NA 0.574938980241386 99.311357293691 a5302 gain_cnaBRCA8_(CHD4,WNK1) 224 AS605240 PI3Kgamma 4 45 2.99573227355399 2.32630161961136 3.83664450886634 3.21991117069786 0.616733338168478 1.01193905463113 1.61465923847138 0.389583333394006 0.609456997776698 0.381958820458209 0.458971563131914 NA NA NA 0.326434894146662 99.311357293691 a5303 loss_cnaBRCA7_(FAS,PTEN) 153 Midostaurin KIT 4 43 -0.669430653942629 NA 0.0914593896856302 0.660623569188545 -0.569164179502915 1.36532606570915 1.4642127303681 0.390419031486272 0.416870514522325 0.388716863129463 0.45902541899581 NA NA NA 0.476132251943997 99.311357293691 a5304 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1066 AZD6482 PI3Kbeta 17 26 1.6094379124341 NA 2.17020491733539 1.8344455707084 0.335759346626981 1.48371552125645 1.41283340336289 0.233019016947876 0.226296309377859 0.237649637832593 0.459277243672565 NA NA NA 0.464938003761897 99.311357293691 a5305 loss_cnaBRCA34 1009 ATRA Retinoic acid and retinoid X receptor agonist 5 40 2.30258509299405 NA 3.74103870549997 4.15158739234655 -0.410548686846574 1.13728196558081 1.16149806640645 0.354145142560705 0.360991116778068 0.353464804394181 0.459365753004702 NA NA NA 0.481304509027731 99.311357293691 a5306 MLL3_mut 271 VNLG/124 HDAC, RAR 3 46 1.63315443905142 NA 3.81173462027017 4.17359481119767 -0.361860190927502 1.79898758031388 0.740907544747156 0.444309058173217 0.201146575377895 0.488401276910996 0.459600521690091 NA NA NA 0.761398372105224 99.311357293691 a5307 loss_cnaBRCA29_(MAP2K4) 1175 AG-014699 PARP1, PARP2 7 36 1.6094379124341 NA 4.12690066196417 3.8099787015008 0.316921960463375 0.801536076535712 1.0622458191159 0.308220733604472 0.395393257697309 0.298350866400348 0.459832051294439 NA NA NA 0.386512769307759 99.311357293691 a5308 PIK3CA_mut 1043 JNK Inhibitor VIII JNK 15 28 2.30258509299405 NA 4.91348333555224 4.73510681276087 0.178376522791374 0.783668481254452 0.72767965410504 0.238704378533542 0.227617324236186 0.245130562308707 0.459911174569673 NA NA NA 0.472227210412531 99.311357293691 a5309 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 9 37 1.38629436111989 NA 3.18925105231434 2.77818285815529 0.411068194159048 1.07855612345157 1.5595227804284 0.277053017402667 0.381128237298913 0.263585886219712 0.459976326157132 NA NA NA 0.364766643755369 99.311357293691 a5310 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 164 JQ12 HDAC 14 33 1.63315443905142 NA 1.30352579849285 1.69427720825929 -0.390751409766439 1.60163548416675 1.66097662335776 0.23767558328808 0.243970250178196 0.235254009160293 0.460042121844825 NA NA NA 0.456332577438585 99.311357293691 a5311 gain_cnaBRCA9_(KRAS) 1378 Bleomycin (50 uM) DNA damage 4 44 3.91202300542815 NA 4.48632146112957 3.75148089971983 0.734840561409737 1.57784005704237 1.90876929990392 0.389019619821368 0.465725634312506 0.384981339257043 0.460111703389145 NA NA NA 0.432774975369378 99.311357293691 a5312 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1020 Lenalidomide TNFA 6 39 1.6094379124341 NA 4.45622441537151 4.22372690942455 0.232497505946958 0.96119779781234 0.671746143040095 0.326780306899983 0.241883103015962 0.346109178825729 0.460220531009979 NA NA NA 0.589248236195828 99.311357293691 a5313 gain_cnaBRCA15 178 BAY 61-3606 SYK 22 26 2.07944154167984 NA 2.90773354163806 3.25484605860229 -0.347112516964234 1.82305429984604 1.40430992896716 0.215724857518524 0.19040163367243 0.247176573920209 0.460244814654699 NA NA NA 0.470541357422512 99.311357293691 a5314 loss_cnaBRCA33 276 CAY10603 HDAC6 6 43 2.99573227355399 NA 0.892718767458018 1.21500313766288 -0.32228437020486 0.535720986893511 1.03439271389158 0.324453541865328 0.601589965839667 0.311568677811318 0.460280873770653 NA NA NA 0.256731407450596 99.311357293691 a5315 gain_cnaBRCA13_(FGFR1,WHSC1L1) 153 Midostaurin KIT 10 37 -0.669430653942629 NA 0.916816161137886 0.529851065472192 0.386965095665694 1.34448509565688 1.48487626047147 0.265430008279546 0.287816575219552 0.260604271188785 0.4603035934787 NA NA NA 0.441847221223461 99.311357293691 a5316 gain_cnaBRCA30_(CRNKL1,FOXA2) 179 5-Fluorouracil DNA antimetabolite 5 44 3.46573590279973 NA 4.55262964029021 3.98339112529984 0.569238514990372 2.16515254462721 1.5604763646636 0.351220300865151 0.26290919612243 0.364785092475967 0.460456883072831 NA NA NA 0.595244112696081 99.311357293691 a5317 loss_cnaBRCA33 197 Bryostatin 1 PRKC 6 42 -4.8283137373023 NA -3.08192833328559 -2.76750043591985 -0.314427897365746 1.28161471074501 0.922418412659386 0.324842322614581 0.245337303582422 0.340873396552474 0.460476145351804 NA NA NA 0.583934922990847 99.311357293691 a5318 loss_cnaBRCA57 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 40 2.30258509299405 NA 3.58631045061535 3.12568654416897 0.460623906446375 0.691341634671126 1.35173753675283 0.353107605376371 0.666275374353081 0.34076430810148 0.460673805377607 NA NA NA 0.253113938784176 99.311357293691 a5319 gain_cnaBRCA58_(CCND1) 1019 Bosutinib SRC, ABL, TEC 9 36 0.693147180559945 NA 2.45498660889066 2.71450151941481 -0.25951491052415 0.950415565888321 0.932264590859543 0.277357846293916 0.273054145826821 0.278370446618463 0.46078573230644 NA NA NA 0.476011389350875 99.311357293691 a5320 loss_cnaBRCA34 275 I-BET BRD2, BRD3, BRD4 5 44 2.99573227355399 NA 3.60990150552174 4.08769555408292 -0.477794048561188 1.22013742743659 1.37378901356999 0.350961071850053 0.39159035516597 0.347792888021118 0.460786045765 NA NA NA 0.448702522149609 99.311357293691 a5321 loss_cnaBRCA24 1371 PLX4720 (rescreen) BRAF 3 44 2.30258509299405 NA 5.10511743072652 4.68001301966811 0.425104411058413 0.614505768158353 0.970972668439539 0.443764468928596 0.691782621231421 0.437812952800827 0.460931028685622 NA NA NA 0.355828926531583 99.311357293691 a5322 loss_cnaBRCA29_(MAP2K4) 294 MPS-1-IN-1 MPS1 7 42 2.99573227355399 NA 5.06183998977154 4.7056306551513 0.35620933462024 1.12071391500471 1.18182621281075 0.303362971540882 0.317841448964915 0.301405850334849 0.461128839608772 NA NA NA 0.461088876790353 99.311357293691 a5323 gain_cnaBRCA47_(EGFR) 260 NG-25 MAP3K7 (TAK1) 7 42 2.32630161961136 NA 2.8736651732748 3.26412310990875 -0.390457936633946 1.20989526185787 1.29815606526824 0.303332915002406 0.322720444441094 0.300778887131158 0.461172988129997 NA NA NA 0.455444582989523 99.311357293691 a5324 gain_cnaBRCA48 300 CX-5461 RNA Pol I 5 44 2.32630161961136 NA 3.37394528849057 3.97354938467067 -0.599604096180101 1.93000137669664 1.6888248246559 0.350507363427702 0.310675475893376 0.355042208893555 0.46136248035916 NA NA NA 0.536367589546106 99.311357293691 a5325 gain_cnaBRCA63 276 CAY10603 HDAC6 7 42 2.99573227355399 NA 1.4336905410707 1.13251461277993 0.301175928290774 1.21363637351744 0.956860013173965 0.303194360936092 0.248159938893299 0.31475443026588 0.461376534673456 NA NA NA 0.5510153370811 99.311357293691 a5326 gain_cnaBRCA31 1175 AG-014699 PARP1, PARP2 13 30 1.6094379124341 NA 4.03869127399071 3.78481837752996 0.253872896460745 1.18114360985223 0.957915063370269 0.246891138836652 0.214938212714461 0.265026520793539 0.461395432993818 NA NA NA 0.50237933550102 99.311357293691 a5327 loss_cnaBRCA28_(GPS2) 207 AS601245 JNK 4 44 2.07944154167984 NA 2.72267612209323 2.22470294870116 0.497973173392073 1.20866720159382 1.29072014792474 0.387368436295699 0.412001891616995 0.385810335565559 0.462006876987467 NA NA NA 0.480577864873183 99.311357293691 a5328 loss_cnaBRCA33 310 YM201636 FYV1 6 43 1.63315443905142 NA 2.70350932682027 2.37436397081979 0.329145356000487 1.15318519822096 1.00139262107233 0.323129802770921 0.285422806768822 0.328687618696477 0.462102408900845 NA NA NA 0.530359929902628 99.311357293691 a5329 gain_cnaBRCA48 301 PHA-793887 CDK-pan 5 43 2.32630161961136 NA 3.43832950451727 2.8622629761035 0.576066528413774 2.50180259577461 1.53801142548172 0.350320439258946 0.230260584662721 0.37455282767704 0.462207603827198 NA NA NA 0.638730449264393 99.311357293691 a5330 ASH1L_mut 1149 TW 37 BCL2, BCL2L1 3 40 1.6094379124341 NA 0.373847809193861 -0.181101646170552 0.554949455364413 1.56673232114677 1.23079980144427 0.444213915624998 0.354208212771291 0.450885233092509 0.462271313396752 NA NA NA 0.604887595076728 99.311357293691 a5331 loss_cnaBRCA18 345 KIN001-270 CDK9 16 33 2.99573227355399 NA 5.00245563943558 5.15855976332384 -0.156104123888268 0.568532569529804 0.74202465469975 0.225779445626885 0.274573757519945 0.210375926055224 0.462292532572594 NA NA NA 0.421414709274955 99.311357293691 a5332 loss_cnaBRCA57 1371 PLX4720 (rescreen) BRAF 5 42 2.30258509299405 NA 5.00730983177549 4.67141371425474 0.335896117520751 0.596715643927818 0.986175868261269 0.350625839909069 0.562908180703543 0.340604681508757 0.462454321938528 NA NA NA 0.310638936623129 99.311357293691 a5333 loss_cnaBRCA20 208 SB-715992 KIF11 3 46 -2.05572501506252 NA -1.94883662514215 -1.19366423955127 -0.755172385590876 1.44124728731079 1.72177227429235 0.441421900455364 0.523971418534252 0.43860178077339 0.462505611263266 NA NA NA 0.46373296142864 99.311357293691 a5334 gain_cnaBRCA27_(CLTC,PPM1D) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 9 33 -1.38629436111989 0.693147180559945 0.0699182824830417 -0.403735019166632 0.473653301649674 1.17120537059005 1.80699760212815 0.27878668598316 0.404415240523572 0.262121710118398 0.462809392353087 NA NA NA 0.356244337409973 99.311357293691 a5335 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 7 40 2.77258872223978 NA 5.27580208949957 4.96454387676468 0.311258212734892 1.06654629866593 1.02018795985297 0.303225749174193 0.291837506842621 0.305098888620239 0.463077428189744 NA NA NA 0.493742874465731 99.311357293691 a5336 gain_cnaBRCA13_(FGFR1,WHSC1L1) 32 VX-680 AURKA, AURKB, AURKC, FLT3, ABL1, JAK2 3 9 0.693147180559945 NA 0.36237441286394 1.46739685131172 -1.10502243844778 2.56996064889321 2.06167148902923 0.50855610476449 0.429976404083726 0.535983760908534 0.463177295042535 NA NA NA 0.548881512043067 99.311357293691 a5337 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1149 TW 37 BCL2, BCL2L1 6 37 1.6094379124341 NA 0.20787610415325 -0.19918321740973 0.40705932156298 1.04658175005521 1.27493441101609 0.325823873609556 0.388941734882637 0.319278637430896 0.463318664141041 NA NA NA 0.418397498679011 99.311357293691 a5338 ASH1L_mut 330 XMD13-2 RIPK 3 45 2.32630161961136 NA 3.21732166271497 3.75460121643335 -0.537279553718387 0.653324824676601 1.23814315195554 0.440911145431762 0.822377374048724 0.433939769298727 0.463402519321032 NA NA NA 0.289015683588614 99.311357293691 a5339 gain_cnaBRCA61_(NOTCH2) 140 Vinorelbine Microtubules 3 44 -2.74887219562247 NA -2.91864317404145 -3.64626079357113 0.727617619529682 2.48996111453945 1.59919917544009 0.44123769857402 0.292220474962824 0.454988741055002 0.463472014969797 NA NA NA 0.664792306074277 99.311357293691 a5340 gain_cnaBRCA61_(NOTCH2) 292 Masitinib KIT 3 45 2.99573227355399 NA 3.5593066231832 4.04039543193754 -0.481088808754345 0.577540532268791 1.10903500688404 0.440831075136167 0.832995749864432 0.433790462670802 0.463483247806861 NA NA NA 0.284164599961611 99.311357293691 a5341 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1049 PD-173074 FGFR1, FGFR3 8 35 0.693147180559945 NA 2.66753631464158 2.99953031567239 -0.331994001030811 1.67546515147112 1.00128987082001 0.289988786509427 0.198150346928617 0.331566323305481 0.463522368585902 NA NA NA 0.604318547633131 99.311357293691 a5342 gain_cnaBRCA64_(SDHC) 1046 681640 WEE1, CHEK1 6 30 0.693147180559945 NA 2.92902274193339 2.57474931193446 0.354273429998925 1.46773447177654 0.983747817161604 0.331481553026334 0.241374333581001 0.360126267950567 0.463651983638283 NA NA NA 0.591926162930295 99.311357293691 a5343 TP53_mut 1241 CHIR-99021 GSK3B 36 10 2.30258509299405 NA 4.28775016959398 4.02894001490162 0.258810154692362 0.851330884531931 1.36767950272325 0.264266923122134 0.304006537757242 0.189233043397254 0.463656593836696 NA NA NA 0.581047165650153 99.311357293691 a5344 gain_cnaBRCA10_(MDM2,NUP107) 294 MPS-1-IN-1 MPS1 5 44 2.99573227355399 NA 4.38897353299518 4.79828408590407 -0.409310552908889 1.14972780968832 1.17654257992587 0.348561714783918 0.356006482108012 0.347892681397623 0.463839128331458 NA NA NA 0.485613369579085 99.311357293691 a5345 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1262 UNC1215 LMBL3 9 37 0 NA 2.8889706172265 2.72554591075311 0.163424706473391 0.65303413451119 0.581347300107872 0.274652288684648 0.250254462725319 0.281113727444966 0.463849633442101 NA NA NA 0.505694119004994 99.311357293691 a5346 BRCA1_mut 165 DMOG Prolyl-4-Hydroxylase 4 42 8.29404964010203 NA 7.02731711329039 7.62166281260356 -0.594345699313166 0.844747132385885 1.576534875856 0.386505243249437 0.703578238418531 0.376994958002727 0.464049373201644 NA NA NA 0.274376312919172 99.311357293691 a5347 ARID1A_mut 1067 CCT007093 PPM1D 5 41 1.88706964903238 NA 3.7777855945898 4.123178983579 -0.345393388989201 0.706102699783641 1.01119768703648 0.349813237864625 0.489154607530936 0.341568610586369 0.464148415767118 NA NA NA 0.364487391726268 99.311357293691 a5348 loss_cnaBRCA29_(MAP2K4) 1008 Methotrexate Dihydrofolate reductase (DHFR) 6 39 -1.6094379124341 NA 0.376411837425188 0.729763649375197 -0.353351811950009 1.26940487272944 1.06593725491925 0.323716629910373 0.278360213940443 0.331494007099673 0.464410456829543 NA NA NA 0.540698401745179 99.311357293691 a5349 loss_cnaBRCA34 1377 Afatinib (rescreen) ERBB2, EGFR 5 42 2.30258509299405 NA 3.45576012390735 2.76069727358548 0.695062850321868 1.24799868275101 2.04966456600353 0.349011931842789 0.55694197432141 0.339110536353327 0.464504678624691 NA NA NA 0.314933404566566 99.311357293691 a5350 BRCA1_mut 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 4 39 1.6094379124341 NA 3.37068195717985 2.81639762151436 0.554284335665498 0.392837268133855 1.48116719489568 0.387637775551423 1.41097696330744 0.374221315173359 0.464515725961923 NA NA NA 0.0913391071555589 99.311357293691 a5351 BRCA1_mut 1010 Gefitinib EGFR 4 41 -0.693147180559945 NA 1.76736789000738 1.36404707562224 0.403320814385141 0.573771355387422 1.07049958774644 0.386491018962948 0.702929504232241 0.376759429897766 0.464626710980042 NA NA NA 0.275484359120192 99.311357293691 a5352 gain_cnaBRCA31 173 FH535 unknown 16 32 3.46573590279973 NA 1.76598579574339 1.47650420742421 0.289481588319177 1.66437413911145 1.04859294867724 0.225750962389186 0.173928194098066 0.276066693643464 0.46468455025673 NA NA NA 0.531919647957202 99.311357293691 a5353 loss_cnaBRCA29_(MAP2K4) 1264 SGC0946 Q8TEK3 (DOT1L) 7 39 -0.693147180559945 NA 2.10676921296295 1.92270369287258 0.184065520090374 0.494742755152217 0.624031355978033 0.302728348098582 0.372042881221661 0.294961973187855 0.464740007200712 NA NA NA 0.406088337742832 99.311357293691 a5354 loss_cnaBRCA60 231 FMK RSK 3 46 2.99573227355399 2.32630161961136 5.3441629356713 5.60521231226073 -0.261049376589427 0.578685114790686 0.595078175592111 0.439188850067383 0.451107813070067 0.43868081085259 0.464759764620962 NA NA NA 0.520007991203758 99.311357293691 a5355 gain_cnaBRCA16 1261 rTRAIL TR10A (DR4), TR10B (DR5) 16 31 -2.30258509299405 NA 0.0149124842324529 -0.220873324074778 0.235785808307231 1.22939043320684 0.929220525053498 0.226944461266891 0.191790827338869 0.253745803014474 0.464800572759406 NA NA NA 0.506611587293935 99.311357293691 a5356 gain_cnaBRCA31 205 BMS-708163 g-secretase 16 32 2.32630161961136 0.940007258491471 4.99886048141451 4.84536403572218 0.153496445692323 0.685776516980079 0.677435470756471 0.225674771444304 0.223828669970018 0.226584600775212 0.464834392849829 NA NA NA 0.468698077531579 99.311357293691 a5357 CDH1_mut 1527 GDC0941 (rescreen) PI3K 4 41 1.38629436111989 NA 1.38820358506804 0.940895085880256 0.447308499187786 2.19530496044864 1.03951660014485 0.386208356715459 0.203756884463274 0.430304334847038 0.464951337141143 NA NA NA 0.712800218052306 99.311357293691 a5358 loss_cnaBRCA28_(GPS2) 1114 Cetuximab EGFR 4 41 4.18661983833127 NA 6.59190934191236 6.2524070759351 0.339502265977266 1.01604870380623 0.868192272012039 0.386098581587265 0.334139756003283 0.391045021848061 0.465077444629849 NA NA NA 0.55898628345338 99.311357293691 a5359 loss_cnaBRCA24 1262 UNC1215 LMBL3 3 43 0 NA 3.00206047315853 2.74045936821926 0.261601104939274 0.224765278142581 0.607076179946155 0.43962788649626 1.16388575273324 0.430919732285455 0.465510529544532 NA NA NA 0.16817945799873 99.311357293691 a5360 BRCA1_mut 170 Shikonin unknown 4 43 2.77258872223978 NA 0.421979726365084 -0.035310292354835 0.457290018719919 0.848268455509277 1.2093877307052 0.384687551547313 0.539086436316171 0.378116965394771 0.465605609333863 NA NA NA 0.375908710950189 99.311357293691 a5361 gain_cnaBRCA10_(MDM2,NUP107) 222 BX-912 PDPK1 (PDK1) 5 44 2.32630161961136 NA 4.35585981193107 3.83013543531739 0.525724376613671 1.13879647989697 1.54458003971657 0.347176741526867 0.461649105783356 0.340367195674846 0.465606730101439 NA NA NA 0.385116650094913 99.311357293691 a5362 gain_cnaBRCA31 1054 PD-0332991 CDK4, CDK6 13 29 1.38629436111989 0.693147180559945 3.13216028997314 2.77116949102102 0.360990798952128 1.29589278378983 1.53642032461994 0.245838750912352 0.27856532844979 0.234955756030775 0.465700131558632 NA NA NA 0.438267871558877 99.311357293691 a5363 gain_cnaBRCA58_(CCND1) 1005 Cisplatin DNA crosslinker 9 36 1.79175946922805 2.30258509299405 3.93007877942433 3.60508474462661 0.324994034797722 0.766238408627657 1.26111260404234 0.274303204588488 0.424142187520709 0.257704215909027 0.465707168605683 NA NA NA 0.337372788016532 99.311357293691 a5364 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1033 Vismodegib SMO 5 40 2.30258509299405 NA 4.51656280146845 4.79017604070856 -0.27361323924011 0.321126448803455 0.816580669459053 0.349078134673327 0.852042054647372 0.335071903454885 0.465774270399287 NA NA NA 0.181446181527246 99.311357293691 a5365 BRCA2_mut 330 XMD13-2 RIPK 6 42 2.32630161961136 NA 3.37878475972044 3.76991217069817 -0.391127410977733 0.820765131874766 1.25859054085907 0.320952861787088 0.476539993949709 0.310766208929841 0.465831882736815 NA NA NA 0.339489581995733 99.311357293691 a5366 loss_cnaBRCA29_(MAP2K4) 1001 AICAR AAPK1 (AMPK) agonist 6 39 7.60090245954208 NA 7.35168349132511 7.7979909579112 -0.446307466586087 1.88591793998404 1.30278868792025 0.322643720824824 0.236652643852502 0.342578555313192 0.46588296172233 NA NA NA 0.596894367381219 99.311357293691 a5367 PIK3CA_mut 1050 ZM-447439 AURKB 13 26 1.38629436111989 0.693147180559945 3.10807130559347 2.77785046954188 0.330220836051597 1.37870430426422 1.29059489145107 0.250202258391627 0.239515344247676 0.255867149512979 0.466025405749686 NA NA NA 0.478792805294238 99.311357293691 a5368 loss_cnaBRCA17 38 AZD-0530 SRC, ABL1 4 10 0.693147180559945 NA 2.79586127452127 2.50272946815247 0.293131806368799 0.64733595256933 0.661801860416948 0.445343424213537 0.452827940739788 0.442929861490749 0.466100942671994 NA NA NA 0.477205772462984 99.311357293691 a5369 loss_cnaBRCA18 157 JNK-9L JNK 15 32 1.63315443905142 NA -0.109771084828173 0.133476508445165 -0.243247593273338 0.953655706779167 1.10134446337249 0.229997609115771 0.255068565672271 0.220864226736542 0.466145031608588 NA NA NA 0.444183409781681 99.311357293691 a5370 PTEN_mut 288 KIN001-055 JAK3, MNK1 9 40 2.32630161961136 NA 4.52857587696082 4.29635398997471 0.23222188698611 0.924682611741469 0.842067439930943 0.271067986090646 0.251136859325994 0.27577587729215 0.466150441588365 NA NA NA 0.503267386576431 99.311357293691 a5371 TP53_mut 197 Bryostatin 1 PRKC 38 10 -4.8283137373023 NA -2.75413284928562 -3.00695400354934 0.252821154263718 0.982021406003454 0.908554506975324 0.261155609823588 0.257449738588314 0.278267459269326 0.466189542711923 NA NA NA 0.453469779741339 99.311357293691 a5372 loss_cnaBRCA28_(GPS2) 193 GW-2580 CSF1R (cFMS) 4 44 2.99573227355399 NA 5.72610582621034 5.43950550764766 0.286600318562679 0.310385243106529 0.768317515230557 0.383638462057877 0.923369666979668 0.373023278633283 0.466304543266345 NA NA NA 0.181717950325934 99.311357293691 a5373 ARID1A_mut 254 AC220 FLT3 5 43 0.0237165266173161 NA 1.94866406017212 2.2557500177863 -0.307085957614182 0.734773862698399 0.897766025481081 0.347073884042999 0.417932609206365 0.34205566806744 0.466342617162922 NA NA NA 0.424382829250192 99.311357293691 a5374 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1129 PF-4708671 RPS6KB1 (p70S6KA) 17 26 2.30258509299405 NA 3.96803559651995 3.70496048319457 0.263075113325383 1.20413671468899 1.1090878935087 0.229335799842949 0.21847611663708 0.237199517608221 0.466358473343635 NA NA NA 0.475217049571675 99.311357293691 a5375 loss_cnaBRCA36_(FAT1,IRF2) 204 Tipifarnib Farnesyl-transferase (FNTA) 9 39 2.77258872223978 NA 1.28526665506821 1.69721726729358 -0.411950612225371 1.59278542505661 1.50016014022033 0.271614244962927 0.258635347702739 0.274604424674866 0.466378399010775 NA NA NA 0.493683318403839 99.311357293691 a5376 TP53_mut 310 YM201636 FYV1 38 11 1.63315443905142 NA 2.35717123207159 2.61329089885928 -0.256119666787691 0.963135719539362 1.20227939847742 0.25141080891428 0.265922716385376 0.213028408464825 0.466413153603017 NA NA NA 0.52699792879257 99.311357293691 a5377 gain_cnaBRCA15 1008 Methotrexate Dihydrofolate reductase (DHFR) 21 24 -1.6094379124341 NA 0.554835286390479 0.794488013999322 -0.239652727608843 1.26705190301646 0.91202075089033 0.219540483186848 0.189141997291747 0.262771134730092 0.466496378547533 NA NA NA 0.476818798041188 99.311357293691 a5378 gain_cnaBRCA31 1143 HG-5-88-01 EGFR, ADCK4 10 16 2.30258509299405 NA 4.71420665089076 4.42149604513449 0.292710605756271 1.15209235209363 0.863022280520259 0.298242339715495 0.254068699635359 0.339169233938914 0.466568171226781 NA NA NA 0.499735287385933 99.311357293691 a5379 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 16 27 -1.38629436111989 0.693147180559945 -2.08166992612643 -2.30278743111885 0.22111750499242 0.66122752227418 1.08803304382494 0.231708623414009 0.334404569597956 0.203226828677087 0.466867101232758 NA NA NA 0.412001386926213 99.311357293691 a5380 loss_cnaBRCA57 256 JW-7-24-1 LCK 5 43 2.32630161961136 NA 2.1995723231441 1.79547573392986 0.404096589214235 0.78881546072565 1.19557085113781 0.346611690494458 0.512282795322619 0.337994681644892 0.466933015620186 NA NA NA 0.345890059289782 99.311357293691 a5381 loss_cnaBRCA24 133 Doxorubicin DNA intercalating 3 45 0.0237165266173161 NA -1.78426078295143 -0.980403930239444 -0.803856852711988 1.37741999237912 1.85657275206247 0.437273509676079 0.583596039813204 0.432978913333174 0.467078215422938 NA NA NA 0.422331329594906 99.311357293691 a5382 loss_cnaBRCA17 1375 Temozolomide DNA akylating agent 9 37 3.40119738166216 NA 5.74681202317321 5.93741850866492 -0.190606485491706 0.630084181322878 0.713801763955266 0.272557327550628 0.302509555297076 0.267030000648263 0.467244918115921 NA NA NA 0.441930260353498 99.311357293691 a5383 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 9 39 0.246860077931526 2.32630161961136 0.0998287352482384 -0.349132011350673 0.448960746598911 1.66452538504431 1.65453006189568 0.271066922343869 0.26972297967505 0.271352426249973 0.467271907970177 NA NA NA 0.479360983628452 99.311357293691 a5384 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 6 42 2.07944154167984 NA 2.88872805348822 3.26081422186313 -0.372086168374914 0.974079802749452 1.18409607733871 0.319907190227141 0.381987355989374 0.314236467374497 0.467277832592457 NA NA NA 0.422227432269866 99.311357293691 a5385 gain_cnaBRCA12_(TERT) 202 GSK-1904529A IGF1R 9 39 0.0237165266173161 NA 2.37342234869437 2.14727105787379 0.226151290820578 0.827324013016311 0.835780826999919 0.271061836637335 0.273352746037264 0.270586837499444 0.467280215025059 NA NA NA 0.474752481461494 99.311357293691 a5386 gain_cnaBRCA15 301 PHA-793887 CDK-pan 22 26 2.32630161961136 NA 2.73311532506523 3.08232378244622 -0.349208457380981 1.69016740977086 1.6053589333644 0.212334023808385 0.206611756540924 0.217526716376837 0.467284630030701 NA NA NA 0.46940339525633 99.311357293691 a5387 gain_cnaBRCA15 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 20 23 1.6094379124341 NA 3.03952704423504 2.71876931230776 0.320757731927285 1.30540318803525 1.52949782524226 0.224302666686589 0.245715450113197 0.209714408633749 0.467346736041919 NA NA NA 0.462368414731005 99.311357293691 a5388 loss_cnaBRCA42 203 BMS-345541 IKBKB 3 46 2.77258872223978 NA 3.11847972160032 3.55932252090505 -0.440842799304731 0.449586980813756 1.02777573691649 0.436504921681327 0.980550634510817 0.428928980778764 0.467477385122519 NA NA NA 0.224414401731537 99.311357293691 a5389 PIK3CA_mut 204 Tipifarnib Farnesyl-transferase (FNTA) 17 31 2.77258872223978 NA 1.40345665254451 1.7387132331228 -0.33525658057829 2.05236715272076 1.13174696349115 0.221039800483848 0.163351172393229 0.296229273321051 0.467633043722738 NA NA NA 0.539507208942266 99.311357293691 a5390 gain_cnaBRCA19 1013 Nilotinib ABL 4 36 0.693147180559945 NA 2.86902883889828 3.24000499835082 -0.370976159452541 0.984360868739639 0.957559340148828 0.386553305355612 0.37687008010338 0.387418454291179 0.467795142694386 NA NA NA 0.516452383279994 99.311357293691 a5391 ARID1A_mut 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 5 43 2.77258872223978 NA -0.87351466134846 -0.385714706211703 -0.487799955136757 1.52457571908372 1.39899214439543 0.34586998084192 0.319957840749246 0.348679552698675 0.467881357807078 NA NA NA 0.526174661145527 99.311357293691 a5392 loss_cnaBRCA38 263 FR-180204 ERK 4 45 2.99573227355399 NA 5.10037033385977 5.38077507208172 -0.280404738221954 0.512986876065176 0.747123878018946 0.381808189289811 0.546611914076195 0.375312242683861 0.467933152323367 NA NA NA 0.36986101242442 99.311357293691 a5393 gain_cnaBRCA27_(CLTC,PPM1D) 201 Epothilone B Microtubules 9 39 -3.44201937618241 NA -4.63322737431851 -4.1440342056472 -0.489193168671313 1.8599201053256 1.79656280651344 0.270610210882052 0.263018377655353 0.272293942019585 0.468018243168857 NA NA NA 0.488181321122617 99.311357293691 a5394 loss_cnaBRCA57 202 GSK-1904529A IGF1R 5 43 0.0237165266173161 NA 1.93131931481265 2.21971571677358 -0.288396401960924 0.450269188322628 0.862034212563113 0.34566014677509 0.640497749879972 0.334553313265174 0.468149849328167 NA NA NA 0.264748132555862 99.311357293691 a5395 PTEN_mut 1199 Tamoxifen ER 8 39 1.6094379124341 NA 3.64417679161315 3.9153227208944 -0.271145929281253 0.634031703402242 1.00280006953383 0.283971044832083 0.427653582346549 0.270388821779101 0.468176430878749 NA NA NA 0.340755614276805 99.311357293691 a5396 loss_cnaBRCA36_(FAT1,IRF2) 345 KIN001-270 CDK9 9 40 2.99573227355399 NA 5.25989212153818 5.07331833317031 0.186573788367871 0.392779299483114 0.737985670040126 0.269807849709016 0.475009219206297 0.252814920319152 0.468213988915597 NA NA NA 0.298536638159814 99.311357293691 a5397 TP53_mut 192 LFM-A13 BTK 38 10 2.77258872223978 NA 4.84086378725409 4.6229742048921 0.217889582361996 0.877254980484009 0.653972445901127 0.259930101670359 0.248376569195173 0.333178536385826 0.468272238007223 NA NA NA 0.396520344344487 99.311357293691 a5398 gain_cnaBRCA15 224 AS605240 PI3Kgamma 22 27 2.99573227355399 2.32630161961136 3.08701847725037 3.4195620080504 -0.33254353080003 1.10142906922058 1.88481941144519 0.210013389010253 0.301920060122758 0.17643256896694 0.468280834459021 NA NA NA 0.445754657058015 99.311357293691 a5399 PTEN_mut 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 9 40 1.63315443905142 NA 3.797193233367 3.52703622277953 0.270157010587463 0.718551784969485 1.05040651522817 0.269694527018125 0.375974308656036 0.257192816943619 0.468399817044789 NA NA NA 0.367148412774205 99.311357293691 a5400 gain_cnaBRCA14_(RAD21) 283 GSK2126458 PI3K, MTOR 21 27 -2.05572501506252 0.0237165266173161 -3.25120649023577 -2.90303122582921 -0.348175264406553 1.44209712635862 1.7723443810098 0.212695521429765 0.241436764585834 0.196448990465487 0.468474377315988 NA NA NA 0.456936673029067 99.311357293691 a5401 gain_cnaBRCA58_(CCND1) 1030 KU-55933 ATM 8 34 2.30258509299405 NA 4.43737752256589 4.17169272739659 0.265684795169294 0.538999429644491 0.986733317485749 0.287483745616805 0.492922219499439 0.269256941527295 0.468678028738654 NA NA NA 0.309757518398212 99.311357293691 a5402 loss_cnaBRCA18 136 Mitomycin C DNA crosslinker 16 32 2.77258872223978 NA -0.355233109660522 -0.0238413737450122 -0.33139173591551 1.11225484300301 1.63008633792353 0.223723695724086 0.297945869150612 0.20329704519679 0.468680962831286 NA NA NA 0.412664612702808 99.311357293691 a5403 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1175 AG-014699 PARP1, PARP2 5 38 1.6094379124341 NA 4.17782242217143 3.81995857307686 0.357863849094568 0.935371955601731 1.03806786464913 0.347947263301205 0.382589885180331 0.344740321207733 0.468693657501407 NA NA NA 0.46094297077078 99.311357293691 a5404 loss_cnaBRCA33 32 VX-680 AURKA, AURKB, AURKC, FLT3, ABL1, JAK2 4 8 0.693147180559945 NA 1.85964909560917 0.856887314745081 1.00276178086409 1.50384815566926 2.40519181293542 0.461171225074221 0.666797227555085 0.416915513960721 0.468754775187756 NA NA NA 0.399615321822535 99.311357293691 a5405 loss_cnaBRCA36_(FAT1,IRF2) 1028 VX-702 p38 8 37 0.693147180559945 NA 3.26629882175946 3.46154118532817 -0.19524236356871 0.600326659512094 0.700376970573125 0.28498951531554 0.325226875193899 0.27876753772892 0.468793666491569 NA NA NA 0.435128599853929 99.311357293691 a5406 gain_cnaBRCA48 165 DMOG Prolyl-4-Hydroxylase 5 41 8.29404964010203 NA 7.09554418521621 7.62783867454707 -0.532294489330863 0.968047914171044 1.58369580650411 0.346107505398049 0.549863784156465 0.336109047674921 0.468866241906933 NA NA NA 0.32131473813573 99.311357293691 a5407 NF1_mut 1203 QL-XII-61 BTK 3 20 2.30258509299405 NA 4.8270918911076 4.13492891011401 0.692162980993598 0.421726520229369 1.58740261121239 0.456716578330984 1.64126026652804 0.436034926555244 0.468881964840916 NA NA NA 0.131401960923672 99.311357293691 a5408 loss_cnaBRCA36_(FAT1,IRF2) 1008 Methotrexate Dihydrofolate reductase (DHFR) 8 37 -1.6094379124341 NA 0.938229824035284 0.627389588051392 0.310840235983892 0.672915318555641 1.15563097874554 0.284732371795099 0.461930687877763 0.268978801798229 0.469192471740575 NA NA NA 0.321263096461053 99.311357293691 a5409 loss_cnaBRCA34 272 AR-42 HDAC 5 44 1.63315443905142 NA -0.331988458064045 0.19582737921436 -0.527815837278405 0.792174242012942 1.58413527017887 0.344358982492558 0.666287553022688 0.333188615400759 0.469214854413725 NA NA NA 0.250504088424703 99.311357293691 a5410 MACF1_mut 1009 ATRA Retinoic acid and retinoid X receptor agonist 3 42 2.30258509299405 NA 4.57815576445577 4.07224337923796 0.505912385217803 1.00575458565634 1.16657774068782 0.436284712367001 0.503017726623291 0.433672242811279 0.469322069458834 NA NA NA 0.479882042255317 99.311357293691 a5411 loss_cnaBRCA24 184 BMS-754807 IGF1R 3 45 0.940007258491471 NA 2.31272710202222 1.58114507819039 0.73158202383183 0.855397547752032 1.7097249460009 0.435043448019001 0.855253824089646 0.427894571897674 0.469339843784433 NA NA NA 0.274472149456301 99.311357293691 a5412 gain_cnaBRCA64_(SDHC) 163 JQ1 BRD4 8 39 0.940007258491471 NA 0.65923872020216 0.24549172394474 0.413746996257419 1.45485413187123 1.46204449252825 0.283208280403216 0.284390707764812 0.282992069237199 0.469365312464771 NA NA NA 0.480710006022693 99.311357293691 a5413 NF1_mut 275 I-BET BRD2, BRD3, BRD4 5 44 2.99573227355399 NA 4.45984506368089 3.99111105883757 0.468734004843323 1.05453763819838 1.38680647354987 0.344229997429775 0.444492437125457 0.337995252966685 0.469380400263438 NA NA NA 0.400291776846316 99.311357293691 a5414 gain_cnaBRCA8_(CHD4,WNK1) 134 Etoposide TOP2 3 44 2.77258872223978 NA 1.59545890416607 2.53721370551378 -0.941754801347704 3.51919629543441 2.07855103421283 0.435382562414257 0.267605078628174 0.453082356818029 0.469390992493897 NA NA NA 0.6900146456056 99.311357293691 a5415 gain_cnaBRCA12_(TERT) 173 FH535 unknown 9 39 3.46573590279973 NA 1.85401900125989 1.50814708610589 0.345871915153992 1.04155266879163 1.3276266202488 0.269692688481826 0.332073379981121 0.260518966612145 0.469519672186968 NA NA NA 0.409183602816866 99.311357293691 a5416 gain_cnaBRCA19 1264 SGC0946 Q8TEK3 (DOT1L) 4 42 -0.693147180559945 NA 1.73876921335287 1.97089884903237 -0.232129635679502 0.469198913956803 0.617039179941058 0.38172812016374 0.494736089054274 0.376199183497028 0.469557059961024 NA NA NA 0.410367734103201 99.311357293691 a5417 CDH1_mut 221 TAK-715 p38a 4 45 2.99573227355399 2.32630161961136 4.12985943762499 4.51346767178634 -0.383608234161345 0.90592423311094 1.01503653923553 0.380403440309048 0.42344405872005 0.377925541922124 0.469562867287553 NA NA NA 0.470198891389956 99.311357293691 a5418 loss_cnaBRCA38 150 Bicalutamide ANDR (androgen receptor) 4 44 0.0237165266173161 NA 2.54455596176184 2.78240881451551 -0.237852852753674 0.176291974247835 0.644324229487038 0.380817949179754 1.34919841795688 0.369150874464296 0.469569496399597 NA NA NA 0.0923348765109823 99.311357293691 a5419 loss_cnaBRCA29_(MAP2K4) 1194 SB-505124 TGFR1 (ALK5) 7 40 2.30258509299405 NA 4.15510920095665 4.42992981969551 -0.274820618738866 1.03140408406411 0.901365003427647 0.298793924306516 0.266452909179855 0.304893819588954 0.469601735922094 NA NA NA 0.527240642931247 99.311357293691 a5420 gain_cnaBRCA31 310 YM201636 FYV1 16 33 1.63315443905142 NA 2.26234864764978 2.48851904072048 -0.226170393070699 1.0378917442711 1.009752113299 0.221993084466642 0.217913278835776 0.223986055678329 0.469790978131507 NA NA NA 0.476274701464045 99.311357293691 a5421 loss_cnaBRCA20 265 Tubastatin A HDAC6 3 46 2.99573227355399 NA 5.11433633791796 4.66420013388632 0.450136204031645 0.811386277217143 1.04578194788276 0.434122455069405 0.55477423844966 0.430430267937757 0.46989735867278 NA NA NA 0.441934631653529 99.311357293691 a5422 POLR2B_mut 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 3 45 0.246860077931526 2.32630161961136 -0.93960407640338 -0.219975057694043 -0.719629018709337 2.15418673136607 1.63015210067154 0.434456993192298 0.334060649539414 0.441449002466018 0.469935637045297 NA NA NA 0.623713750942616 99.311357293691 a5423 gain_cnaBRCA27_(CLTC,PPM1D) 1059 AZD8055 MTORC1/2 10 33 0.693147180559945 NA 0.334447485291611 0.0686074755758433 0.265840009715768 0.828586559744871 1.0551237183179 0.263270711503662 0.320835532014449 0.251951505876084 0.469944808551179 NA NA NA 0.416552275136851 99.311357293691 a5424 loss_cnaBRCA33 9 MG-132 Proteasome 5 9 0 NA -0.0986155535492109 0.566770662867892 -0.665386216417103 1.39147328184636 1.69364127437702 0.41605496843792 0.478188280794149 0.392873170064808 0.470075423119926 NA NA NA 0.44690665823254 99.311357293691 a5425 BRCA1_mut 226 GSK1070916 AURKB 4 45 0.940007258491471 2.32630161961136 3.08477651776555 2.34342959289313 0.74134692487242 0.713877516901044 2.00813456083509 0.379916572532471 1.03847916109002 0.369171936647577 0.470128460259421 NA NA NA 0.148305099157947 99.311357293691 a5426 gain_cnaBRCA10_(MDM2,NUP107) 1033 Vismodegib SMO 3 42 2.30258509299405 NA 5.07839946981517 4.73701564824379 0.341383821571379 0.627235314660857 0.79076075973568 0.435487602181513 0.544267539776462 0.431715683116965 0.470129362213763 NA NA NA 0.449819260062139 99.311357293691 a5427 gain_cnaBRCA64_(SDHC) 1016 Temsirolimus MTOR 8 36 -1.6094379124341 NA -2.10076090352565 -1.67320319369076 -0.427557709834888 1.59776211326405 1.48145515564527 0.284760275337317 0.267597852199309 0.288606582660046 0.470330132534223 NA NA NA 0.503991295565195 99.311357293691 a5428 gain_cnaBRCA9_(KRAS) 224 AS605240 PI3Kgamma 4 45 2.99573227355399 2.32630161961136 2.71836677781264 3.31931363568041 -0.600946857867773 1.66136110313854 1.57808709406536 0.3794974550064 0.361719590480661 0.380807155782292 0.470615658918094 NA NA NA 0.529828322230278 99.311357293691 a5429 loss_cnaBRCA60 273 CUDC-101 HDAC, EGFR 3 46 1.63315443905142 NA -0.665989600612772 0.015047646704298 -0.68103724731707 0.165366884617153 1.60564316779793 0.433373304931241 4.11834115937881 0.424152302937322 0.470659776725236 NA NA NA 0.0111426301347818 99.311357293691 a5430 loss_cnaBRCA17 263 FR-180204 ERK 11 38 2.99573227355399 NA 5.21615218730562 5.39891277680933 -0.182760589503713 1.01095364567266 0.639544439231788 0.248833615229889 0.180780385219451 0.285766833846983 0.470969113743296 NA NA NA 0.580431006801526 99.311357293691 a5431 gain_cnaBRCA12_(TERT) 136 Mitomycin C DNA crosslinker 9 39 2.77258872223978 NA 0.18921150308887 -0.208963006210476 0.398174509299347 1.14871463890572 1.54225568515578 0.268792898605586 0.346626129600518 0.258176716825737 0.470994751339573 NA NA NA 0.395538736115271 99.311357293691 a5432 PTEN_mut 1036 PLX4720 BRAF 6 37 2.30258509299405 NA 4.9285630549092 4.54278637509581 0.385776679813386 0.91633310889921 1.23953521403255 0.320207356965362 0.421000481229822 0.311226882016807 0.471012705093192 NA NA NA 0.390663346770489 99.311357293691 a5433 gain_cnaBRCA15 29 AZ628 BRAF 6 8 1.38629436111989 NA 2.96106011773619 2.12985816101217 0.831201956724017 1.29396108582011 2.47671817010024 0.401969965870404 0.642370134490718 0.335606193211066 0.471017444481751 NA NA NA 0.433601176290841 99.311357293691 a5434 gain_cnaBRCA47_(EGFR) 273 CUDC-101 HDAC, EGFR 7 42 1.63315443905142 NA -0.426158915904328 0.0399365561402307 -0.466095472044559 0.75886555981407 1.65732855377509 0.296593058621612 0.61420032312279 0.281232994497608 0.471134191789468 NA NA NA 0.24110381884898 99.311357293691 a5435 gain_cnaBRCA58_(CCND1) 185 OSI-906 IGF1R 9 39 0.940007258491471 NA 2.64683168131655 2.95041104289209 -0.303579361575541 1.34504029266589 1.07927885274423 0.268654999546123 0.225702801046831 0.281279820135126 0.471221050671862 NA NA NA 0.541024903967419 99.311357293691 a5436 PTEN_mut 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 8 39 2.77258872223978 NA 4.77076828257646 5.06015957529417 -0.289391292717704 1.32712764467408 0.961194908454073 0.281860049698871 0.218058371309697 0.301074516908484 0.471470944703678 NA NA NA 0.572959188060294 99.311357293691 a5437 PIK3CA_mut 308 XL-880 MET 17 32 1.63315443905142 NA 2.07636451842844 1.72626669415009 0.350097824278352 1.5169885299127 1.65193312220312 0.217821818352004 0.230784753724209 0.211932202080578 0.471574637164347 NA NA NA 0.461015823110471 99.311357293691 a5438 PIK3CA_mut 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 17 32 3.68887945411394 NA 3.62977294921332 3.36897912776934 0.260793821443975 1.31724411332756 1.1305608392124 0.217802868736689 0.197984427339872 0.230676503553454 0.471612988060804 NA NA NA 0.494465084415824 99.311357293691 a5439 gain_cnaBRCA61_(NOTCH2) 190 Bleomycin DNA damage 3 45 4.15888308335967 NA 3.19364536479175 2.0040494090986 1.18959595569315 2.08230437255049 2.77514358489854 0.432792178378826 0.571288218655608 0.428661047365823 0.47162931133034 NA NA NA 0.43074041551946 99.311357293691 a5440 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1262 UNC1215 LMBL3 18 28 0 NA 2.83697802306723 2.70644035134619 0.130537671721037 0.642074100694395 0.563605840955891 0.219335452807227 0.203306240790374 0.23161163748701 0.471674432591109 NA NA NA 0.485539306358983 99.311357293691 a5441 MLL3_mut 1166 QL-VIII-58 MTOR, ATR 3 23 2.30258509299405 NA -1.96608799543349 -1.46071477934097 -0.505373216092527 1.5071974544943 1.08447555977405 0.448908853951063 0.335306574852258 0.466007012825462 0.471675840647117 NA NA NA 0.624472353112269 99.311357293691 a5442 gain_cnaBRCA47_(EGFR) 333 T0901317 LXR 7 41 2.32630161961136 NA 4.92959193317287 4.70228766724916 0.227304265923709 0.619990549759539 0.785457607633361 0.296778699886791 0.366625371970376 0.289390877005562 0.471702998414055 NA NA NA 0.411014811159258 99.311357293691 a5443 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 201 Epothilone B Microtubules 6 42 -3.44201937618241 NA -4.7367628392619 -4.16418579413181 -0.572577045130096 1.42274462762063 1.84940611731269 0.316705914005036 0.402445410099818 0.30960049270416 0.471720485574785 NA NA NA 0.403229963701636 99.311357293691 a5444 gain_cnaBRCA58_(CCND1) 225 Genentech Cpd 10 AURKA, AURKB 10 39 2.32630161961136 NA 3.34893515536037 2.93322454727914 0.415710608081225 1.53113935122657 1.63631112027365 0.257135032818233 0.271504097747997 0.254053524987169 0.471785005881204 NA NA NA 0.462083177552615 99.311357293691 a5445 gain_cnaBRCA19 156 AZD6482 PI3Kbeta 4 43 1.63315443905142 NA 1.54511598463373 2.10058364541916 -0.555467660785428 1.01440127604306 1.49159018233457 0.379256529054781 0.547581784352812 0.37239964928975 0.471890543109633 NA NA NA 0.37034551049326 99.311357293691 a5446 loss_cnaBRCA22_(SYNCRIP,ZNF292) 156 AZD6482 PI3Kbeta 17 30 1.63315443905142 NA 1.84742670292773 2.16997689139291 -0.322550188465182 2.0142802716879 1.04408637241069 0.220227278298628 0.160131731913799 0.308930560716395 0.47193222564726 NA NA NA 0.545121084645311 99.311357293691 a5447 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 185 OSI-906 IGF1R 9 39 0.940007258491471 NA 3.13970804607019 2.83667034333356 0.303037702736632 0.885488805640559 1.17503386787326 0.268170169281806 0.342226463853957 0.257896994309715 0.472017173251651 NA NA NA 0.400013708498926 99.311357293691 a5448 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 6 40 0 NA 1.22290829065627 0.567761173636214 0.655147117020057 1.60927895491657 2.11487141626664 0.317467702538906 0.407105999254194 0.309781063747403 0.472200765951411 NA NA NA 0.400542643935548 99.311357293691 a5449 MLL3_mut 295 NVP-BHG712 EPHB4 3 46 2.32630161961136 NA 3.38775039440557 3.91924898217075 -0.531498587765179 1.31871463130979 1.22720691484222 0.431677691845211 0.403042914020964 0.433096148120641 0.47238802060684 NA NA NA 0.560643460283802 99.311357293691 a5450 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 204 Tipifarnib Farnesyl-transferase (FNTA) 15 33 2.77258872223978 NA 1.3846729117895 1.72693271646125 -0.342259804671749 1.6097337775078 1.47446506664315 0.225629416159591 0.212618887330325 0.232124729445749 0.472388084941817 NA NA NA 0.489969422807411 99.311357293691 a5451 loss_cnaBRCA28_(GPS2) 204 Tipifarnib Farnesyl-transferase (FNTA) 4 44 2.77258872223978 NA 2.14589785372659 1.57216549784448 0.573732355882106 0.671007925875944 1.55889964500774 0.378222154825316 0.855030669173016 0.368036748048177 0.472585822016307 NA NA NA 0.206836652611144 99.311357293691 a5452 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1049 PD-173074 FGFR1, FGFR3 6 37 0.693147180559945 NA 3.25210417960788 2.88678990508159 0.365314274526289 0.935698319103792 1.1712897611555 0.319008028372223 0.390418863716871 0.311890606954422 0.472665084009665 NA NA NA 0.418595912583607 99.311357293691 a5453 gain_cnaBRCA64_(SDHC) 1066 AZD6482 PI3Kbeta 7 36 1.6094379124341 NA 1.60595476169899 2.03742736392298 -0.431472602223986 0.915267462048187 1.51343059643085 0.299325469754352 0.47141695746338 0.285095731011079 0.472800979497957 NA NA NA 0.331369920706413 99.311357293691 a5454 ARID1A_mut 156 AZD6482 PI3Kbeta 5 42 1.63315443905142 NA 1.60513810718338 2.10666357513433 -0.501525467950957 1.64494708986284 1.44587093246546 0.342417042015994 0.304888510421801 0.346867384003474 0.472937141332854 NA NA NA 0.544287025854406 99.311357293691 a5455 gain_cnaBRCA8_(CHD4,WNK1) 276 CAY10603 HDAC6 4 45 2.99573227355399 NA 0.831064316560789 1.2061597835113 -0.375095466950516 0.997563444767268 0.993367807378355 0.37749780889639 0.37601164007972 0.377599781434883 0.472944082547935 NA NA NA 0.515549705024212 99.311357293691 a5456 loss_cnaBRCA28_(GPS2) 1052 RO-3306 CDK1 3 40 1.6094379124341 NA 4.0111640186726 3.48926156130094 0.521902457371661 1.06250063085046 1.21057451388583 0.433555164786391 0.491202021173308 0.431119647229647 0.473012603950265 NA NA NA 0.489198849173288 99.311357293691 a5457 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 178 BAY 61-3606 SYK 15 33 2.07944154167984 NA 2.84644124568861 3.20907626528387 -0.362635019595265 1.76248833178422 1.53792455826613 0.225296501654444 0.205751727858623 0.235795063968615 0.473038131722213 NA NA NA 0.498742828084802 99.311357293691 a5458 loss_cnaBRCA34 257 NPK76-II-72-1 PLK3 5 44 2.32630161961136 NA 2.99232358774993 3.53425992312738 -0.541936335377449 1.70597140302406 1.5762259628951 0.341338308397206 0.317670234340854 0.343818937217643 0.473100476927703 NA NA NA 0.528893307449876 99.311357293691 a5459 MLL3_mut 1032 Afatinib ERBB2, EGFR 3 42 -0.693147180559945 NA -0.450352523073076 0.343387714214298 -0.793740237287374 0.555452766550757 1.8757651409969 0.432429569076768 1.42899682040713 0.423155447310174 0.473233815602204 NA NA NA 0.112874074627956 99.311357293691 a5460 MLL3_mut 1039 SL 0101-1 RSK, AURKB, PIM3 3 40 2.30258509299405 NA 4.25933220740409 4.6780405705372 -0.418708363133109 1.47392975021076 0.932887969832746 0.433295701460248 0.28407620042491 0.44883027402334 0.473275840980651 NA NA NA 0.673274431395243 99.311357293691 a5461 NF1_mut 333 T0901317 LXR 4 44 2.32630161961136 NA 5.00045314002928 4.71134375748429 0.289109382544996 0.503752846665455 0.780953896167163 0.377457102049114 0.573911163894614 0.370200320356828 0.473476915289806 NA NA NA 0.351699274545187 99.311357293691 a5462 gain_cnaBRCA64_(SDHC) 1025 SB 216763 GSK3A, GSK3B 8 31 2.30258509299405 NA 5.06915141671088 4.84271227944659 0.226439137264289 0.90861923814805 0.757830985580472 0.287150485201072 0.249212351838178 0.298798995518565 0.473553618268421 NA NA NA 0.531438417742874 99.311357293691 a5463 gain_cnaBRCA10_(MDM2,NUP107) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 3 43 1.63315443905142 NA 2.58037086644521 1.89168037666283 0.688690489782371 2.24432864237419 1.55772504550617 0.431684027594708 0.306858129767409 0.442112997906244 0.4735628980569 NA NA NA 0.650313653321511 99.311357293691 a5464 loss_cnaBRCA33 51 Dasatinib ABL, SRC, KIT, PDGFR 4 8 0.246860077931526 NA 2.31297697712001 1.7915523206461 0.521424656473904 0.832224127324704 1.2535198212106 0.455971736607517 0.626543546808831 0.415968417611725 0.473649406744622 NA NA NA 0.413772746879269 99.311357293691 a5465 gain_cnaBRCA14_(RAD21) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 19 24 0.693147180559945 NA 1.88950297882672 1.51763188888331 0.37187108994341 1.1852900454193 1.97487585558029 0.222050335924972 0.313738473870216 0.188300995676582 0.473722339814272 NA NA NA 0.44907715695248 99.311357293691 a5466 loss_cnaBRCA60 204 Tipifarnib Farnesyl-transferase (FNTA) 3 45 2.77258872223978 NA 2.23244589792809 1.57914523613954 0.653300661788552 0.793998785359191 1.54179417029337 0.430662678409075 0.822798061955486 0.423727547020263 0.473800784150175 NA NA NA 0.289216383455346 99.311357293691 a5467 gain_cnaBRCA27_(CLTC,PPM1D) 288 KIN001-055 JAK3, MNK1 9 40 2.32630161961136 NA 4.52535159859957 4.29707945260599 0.228272145993572 0.408498849050036 0.922270347942303 0.266405935202841 0.558807317387599 0.247511097481205 0.473810819131937 NA NA NA 0.261909270073447 99.311357293691 a5468 gain_cnaBRCA27_(CLTC,PPM1D) 302 PI-103 PI3Ka, PRKDC (DNAPK) 9 39 2.32630161961136 NA 1.53150518915308 1.03541653715512 0.496088651997963 2.55306561492484 1.67470928639873 0.267066727571549 0.194310968389493 0.296223742250062 0.473831946586115 NA NA NA 0.590882597335096 99.311357293691 a5469 PTEN_mut 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 36 1.38629436111989 0.693147180559945 3.71942627590886 3.38576370889546 0.333662567013396 0.819447293838332 1.0750269532918 0.318837089466064 0.407180021854126 0.310376001263689 0.473853349964312 NA NA NA 0.404356876409186 99.311357293691 a5470 gain_cnaBRCA63 1033 Vismodegib SMO 6 39 2.30258509299405 NA 4.97504096345764 4.72665666294715 0.248384300510487 1.29130946720812 0.690010692639767 0.316819386386184 0.192350715934506 0.359971668787111 0.473923199727247 NA NA NA 0.662528968909621 99.311357293691 a5471 loss_cnaBRCA29_(MAP2K4) 1268 XAV 939 TNKS1 (tankyrase-1) 7 40 1.6094379124341 NA 3.89839982150028 3.61997518701442 0.27842463448586 0.700387541493677 0.972873581541206 0.295846578333519 0.397529393358539 0.286187886862737 0.473969594588745 NA NA NA 0.383452147734965 99.311357293691 a5472 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1143 HG-5-88-01 EGFR, ADCK4 9 17 2.30258509299405 NA 4.72656344339886 4.43217248473351 0.294390958665343 1.21235101964348 0.843240221665438 0.299842523265643 0.242826503129362 0.349118734023275 0.474038868953144 NA NA NA 0.527731693302081 99.311357293691 a5473 gain_cnaBRCA62 91 KIN001-135 IKKE 5 9 1.6094379124341 NA 3.81147166245133 3.64341985895182 0.168051803499506 0.378964441408348 0.421307263846042 0.412213029302198 0.443450057939406 0.398881808885491 0.47409520745149 NA NA NA 0.464267355937869 99.311357293691 a5474 gain_cnaBRCA12_(TERT) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 9 36 -0.669430653942629 NA -4.01064887109862 -3.35507714500559 -0.655571726093028 2.25073402658778 2.47645483100247 0.269113210137131 0.291270189346586 0.26472185879831 0.474137869640072 NA NA NA 0.457289454135129 99.311357293691 a5475 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1025 SB 216763 GSK3A, GSK3B 5 34 2.30258509299405 NA 5.12725501839684 4.85414755601609 0.273107462380751 0.712220087299755 0.797348927319475 0.346324221217239 0.383459364950215 0.342519382698466 0.474188613263703 NA NA NA 0.462859014559295 99.311357293691 a5476 gain_cnaBRCA14_(RAD21) 1039 SL 0101-1 RSK, AURKB, PIM3 19 24 2.30258509299405 NA 4.52919321781783 4.74353951271506 -0.214346294897231 1.09254466387234 0.854708684396717 0.221807996973971 0.196189960909713 0.25078286767207 0.474202088502548 NA NA NA 0.487600916872696 99.311357293691 a5477 gain_cnaBRCA12_(TERT) 333 T0901317 LXR 9 39 2.32630161961136 NA 4.90146932738085 4.69712087033329 0.204348457047563 0.631151957110283 0.791414838127672 0.266788915729193 0.323770614580945 0.258206502080515 0.474289472859519 NA NA NA 0.418926436250188 99.311357293691 a5478 gain_cnaBRCA62 193 GW-2580 CSF1R (cFMS) 10 38 2.99573227355399 NA 5.31172017438784 5.50330168151211 -0.191581507124263 0.900467511972927 0.704914386318332 0.256394871467731 0.212757822549874 0.271779822972355 0.474309922481484 NA NA NA 0.544036148657567 99.311357293691 a5479 gain_cnaBRCA15 157 JNK-9L JNK 22 25 1.63315443905142 NA -0.0628381601540199 0.160284860848445 -0.223123021002465 1.03798291819073 1.0749089850746 0.210923772271681 0.214958278303252 0.207573872858621 0.474312352313454 NA NA NA 0.473344211702141 99.311357293691 a5480 gain_cnaBRCA19 1373 Dabrafenib BRAF 4 42 2.30258509299405 NA 4.77942557679713 4.16079518436718 0.618630392429953 1.01289515729806 1.6750244411712 0.377581625143669 0.610754615591383 0.369326188456927 0.474367835010454 NA NA NA 0.328762923424631 99.311357293691 a5481 PTEN_mut 152 CP466722 ATM 9 40 2.77258872223978 NA 2.96101543128388 2.67819518479074 0.282820246493137 1.25117008449658 1.02056521331075 0.265969803461758 0.226044604165014 0.277121190105684 0.474531079058096 NA NA NA 0.540590526091793 99.311357293691 a5482 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 172 Embelin XIAP 15 33 3.46573590279973 NA 2.84340958491781 3.06108608655969 -0.217676501641876 0.961026318572234 0.973446310907022 0.224482090727265 0.22650420434403 0.223614285865497 0.474630486750918 NA NA NA 0.474919543246636 99.311357293691 a5483 loss_cnaBRCA33 268 YM155 BIRC5 (Survivin) 6 43 1.63315443905142 NA -4.03693976465635 -3.53399263974245 -0.502947124913892 1.77221531793066 1.57974438044266 0.314082831228078 0.283795721561171 0.318372472876252 0.474662134500469 NA NA NA 0.533405267814259 99.311357293691 a5484 loss_cnaBRCA60 1175 AG-014699 PARP1, PARP2 3 40 1.6094379124341 NA 4.27467108077188 3.83058811613656 0.444082964635324 0.273909959215579 1.05290554316994 0.431699955592666 1.62127352326686 0.42176904425666 0.474896631984309 NA NA NA 0.0875892751768744 99.311357293691 a5485 PIK3CA_mut 291 KIN001-266 MAP3K8 (COT) 17 32 2.99573227355399 NA 3.94553065093863 3.68997078041157 0.255559870527057 1.31589624645129 1.10682267918551 0.216181313271328 0.194209742003788 0.230895043382305 0.47490131576396 NA NA NA 0.500380217953104 99.311357293691 a5486 TP53_mut 219 AT-7519 CDK9 38 11 2.32630161961136 NA 1.57154686028519 2.01902217946465 -0.447475319179452 1.7317419705354 2.09674638786877 0.246467035820638 0.258396069849312 0.2134141361914 0.475174984038242 NA NA NA 0.528068623210549 99.311357293691 a5487 loss_cnaBRCA36_(FAT1,IRF2) 1218 JQ1 BRD2, BRD3, BRD4 9 37 0 NA 2.30650669023988 2.49482718649129 -0.188320496251409 0.693558387443202 0.705687482300743 0.267691683592847 0.271527963126005 0.266861041147323 0.47518536869862 NA NA NA 0.480143914629712 99.311357293691 a5488 loss_cnaBRCA18 53 CGP-60474 CDK1,CDK2,CDK5,CDK7,CDK9 5 7 -1.36257783450257 NA -2.08489279017456 -1.42544895049898 -0.659443839675578 0.77524323620306 1.85486206856229 0.434379963961858 0.850628304614901 0.355521766740702 0.475243786515894 NA NA NA 0.422157947636068 99.311357293691 a5489 loss_cnaBRCA18 1268 XAV 939 TNKS1 (tankyrase-1) 15 32 1.6094379124341 NA 3.80580462393189 3.59377302725313 0.212031596678756 0.714118377903699 1.02735592674592 0.225291525682797 0.296913793622252 0.20638572393343 0.47526438775031 NA NA NA 0.417725296326347 99.311357293691 a5490 gain_cnaBRCA31 196 Phenformin AAPK1 (AMPK) agonist 16 32 8.29404964010203 NA 7.46864164701848 7.06869880256643 0.399942844452052 2.2967324668582 1.52855980858003 0.220338409778696 0.174135581842125 0.261646840514264 0.47539807819519 NA NA NA 0.535070401137949 99.311357293691 a5491 gain_cnaBRCA62 176 IPA-3 PAK1, PAK2, PAK3 9 38 3.46573590279973 NA 4.8230782271589 4.41957237120373 0.40350585595517 1.42678472186856 1.53035947731414 0.266786963087098 0.282807805389678 0.263667368312275 0.475454210635953 NA NA NA 0.465638347442137 99.311357293691 a5492 BRCA2_mut 1268 XAV 939 TNKS1 (tankyrase-1) 5 42 1.6094379124341 NA 3.3752477392795 3.6955135127305 -0.320265773450999 0.671564453228135 0.963424138658603 0.340290782596934 0.476895064816963 0.332424485333025 0.475674309806481 NA NA NA 0.375187640393893 99.311357293691 a5493 gain_cnaBRCA9_(KRAS) 275 I-BET BRD2, BRD3, BRD4 4 45 2.99573227355399 NA 3.5698725218619 4.08063604044022 -0.510763518578314 2.02379742159459 1.30460759173746 0.375035213572074 0.252378777207787 0.39150739411081 0.475820544241265 NA NA NA 0.65193996672362 99.311357293691 a5494 gain_cnaBRCA16 253 XMD14-99 EPHB3, CAMK1 16 32 2.32630161961136 NA 5.04676677273336 4.87626937396778 0.170497398765573 0.834922308532152 0.743699428107597 0.220102491327376 0.20420750173189 0.229255788456658 0.475868214869625 NA NA NA 0.495323882184358 99.311357293691 a5495 POLR2B_mut 330 XMD13-2 RIPK 3 45 2.32630161961136 NA 3.23121127447729 3.75367524231587 -0.522463967838581 0.680897390240141 1.23787312894083 0.428614413566545 0.767316743062146 0.422065844732908 0.47589476666289 NA NA NA 0.315963607124209 99.311357293691 a5496 gain_cnaBRCA58_(CCND1) 301 PHA-793887 CDK-pan 10 38 2.32630161961136 NA 3.2549206962944 2.83473022452876 0.420190471765642 1.36940902914279 1.70529632504087 0.255437301887715 0.306840734085614 0.24640320019195 0.475952891568122 NA NA NA 0.424739138717485 99.311357293691 a5497 gain_cnaBRCA48 1025 SB 216763 GSK3A, GSK3B 4 35 2.30258509299405 NA 4.62018223837617 4.91990180122933 -0.29971956285316 1.17303216671491 0.745258035358731 0.380048792899563 0.255508392146252 0.402168844390775 0.476010055313649 NA NA NA 0.648929645697837 99.311357293691 a5498 gain_cnaBRCA30_(CRNKL1,FOXA2) 274 PXD101, Belinostat HDAC 5 43 2.99573227355399 NA 1.12727615964348 0.618506507166145 0.508769652477335 2.97415112062941 1.27182585843218 0.339476698966564 0.171063820176584 0.400030907615378 0.476101286330743 NA NA NA 0.723532394190913 99.311357293691 a5499 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1502 Bicalutamide ANDR (androgen receptor) 6 39 2.30258509299405 NA 4.71802100676295 4.53373115236218 0.184289854400772 1.04827206380464 0.492256858765267 0.315167467158841 0.175803458628768 0.374377423329414 0.47621789666824 NA NA NA 0.688434848021611 99.311357293691 a5500 gain_cnaBRCA15 328 SNX-2112 HSP90 22 26 0.940007258491471 NA 0.186883096372516 0.612157300163673 -0.425274203791156 1.91524298442574 2.14605116447054 0.20806812123185 0.222047127831495 0.198165920194208 0.476228172189885 NA NA NA 0.472000336348713 99.311357293691 a5501 PIK3CA_mut 1241 CHIR-99021 GSK3B 16 30 2.30258509299405 NA 4.3735862318277 4.15570088483854 0.21788534698916 1.06821810615555 0.930594119988948 0.222403296767401 0.203970842409061 0.234135744369143 0.476291612484864 NA NA NA 0.497025971855074 99.311357293691 a5502 gain_cnaBRCA14_(RAD21) 1259 BMN-673 PARP1 21 25 2.30258509299405 NA 3.48584084517145 3.15408368456972 0.331757160601737 1.19568972458333 1.80867211797408 0.212638879226319 0.277460911288959 0.183425816821538 0.476331500745345 NA NA NA 0.461138712045048 99.311357293691 a5503 loss_cnaBRCA57 197 Bryostatin 1 PRKC 5 43 -4.8283137373023 NA -2.51255283080748 -2.8410191663793 0.328466335571814 0.370937775853376 1.0069185631358 0.339204952597263 0.885502520783027 0.326209435000269 0.476452476888707 NA NA NA 0.170109494003896 99.311357293691 a5504 BRCA1_mut 1192 GSK269962A ROCK1, ROCK2 4 42 1.6094379124341 NA 3.17108883512258 2.62002504791995 0.551063787202627 0.734358683319966 1.50637027663214 0.375717038988249 0.750401404271983 0.365822265449013 0.476540230094839 NA NA NA 0.253151148807343 99.311357293691 a5505 gain_cnaBRCA61_(NOTCH2) 155 AP-24534 ABL 3 44 -0.669430653942629 NA 1.90108185529811 1.41428779993325 0.486794055364859 0.371795272256557 1.16043273059602 0.428117538403501 1.30930673865306 0.419493558333908 0.47679493405465 NA NA NA 0.134463620048557 99.311357293691 a5506 gain_cnaBRCA12_(TERT) 1003 Camptothecin TOP1 10 35 -2.30258509299405 NA -2.21067411128053 -2.62031211052907 0.409637999248544 1.49790145616386 1.61580368326965 0.257334671085517 0.273474598454315 0.253519659281642 0.476840506248259 NA NA NA 0.464946416852022 99.311357293691 a5507 gain_cnaBRCA63 136 Mitomycin C DNA crosslinker 6 42 2.77258872223978 NA 0.271155769260908 -0.192228293570814 0.463384062831722 2.0326044490415 1.39961664771184 0.312763824974061 0.227975523250595 0.331079273449114 0.477224116579151 NA NA NA 0.609365252282759 99.311357293691 a5508 loss_cnaBRCA38 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 43 1.38629436111989 NA 3.45260874296033 2.81716741845799 0.635441324502336 0.605839060013595 1.51358202500022 0.428075919067546 1.04886159781127 0.419826156763616 0.477246304621989 NA NA NA 0.202594933832202 99.311357293691 a5509 gain_cnaBRCA61_(NOTCH2) 194 AUY922 HSP90 3 44 -1.36257783450257 NA -1.70074963064087 -2.4409969005519 0.740247269911025 1.01365515247697 1.7573673419553 0.427613865467699 0.730275250021822 0.421225120234341 0.477310677395996 NA NA NA 0.335323341789352 99.311357293691 a5510 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 37 1.38629436111989 0.693147180559945 3.11838309631542 3.47600366740845 -0.357620571093032 1.60925819156929 0.964030124683122 0.341694613842907 0.222226969523326 0.370964103648298 0.477459409547809 NA NA NA 0.6506753897986 99.311357293691 a5511 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 7 38 2.30258509299405 NA 3.50167485799981 3.11703394773255 0.384640910267253 1.20578824136292 1.32049640703275 0.294722311059099 0.318995406550397 0.291285086592223 0.477524695708793 NA NA NA 0.464800129258553 99.311357293691 a5512 gain_cnaBRCA64_(SDHC) 1067 CCT007093 PPM1D 9 37 1.88706964903238 NA 4.29716748056717 4.03418267498874 0.262984805578425 0.656772820367453 1.0471566340419 0.266253970104035 0.400419745493258 0.251141803460037 0.477546216211495 NA NA NA 0.356691998839024 99.311357293691 a5513 gain_cnaBRCA47_(EGFR) 229 LY317615 PRKCB (PKCbeta) 7 42 2.99573227355399 2.32630161961136 2.95344775902554 3.42610562416899 -0.472657865143456 0.762630645727163 1.7066024882258 0.292291834871256 0.619772976330869 0.276958382754285 0.477554739142576 NA NA NA 0.241421638450933 99.311357293691 a5514 loss_cnaBRCA28_(GPS2) 192 LFM-A13 BTK 4 44 2.77258872223978 NA 5.08273502849789 4.76935513296784 0.313379895530054 0.949926618676495 0.830131951993311 0.373753615891661 0.329899056799437 0.377506123909057 0.477804008465205 NA NA NA 0.563533982886241 99.311357293691 a5515 gain_cnaBRCA13_(FGFR1,WHSC1L1) 265 Tubastatin A HDAC6 11 38 2.99573227355399 NA 4.88875574624802 4.63473426220517 0.254021484042858 1.1768370110943 0.995966648642207 0.244935637800491 0.215851032596818 0.255050191077345 0.477907874820603 NA NA NA 0.524957977616762 99.311357293691 a5516 loss_cnaBRCA28_(GPS2) 271 VNLG/124 HDAC, RAR 4 45 1.63315443905142 NA 3.87216566200604 4.17626450061954 -0.304098838613496 1.1438272774334 0.787389807439515 0.373212975665344 0.265860803123926 0.386211296793877 0.477955388169366 NA NA NA 0.635813432056056 99.311357293691 a5517 gain_cnaBRCA9_(KRAS) 1033 Vismodegib SMO 4 41 2.30258509299405 NA 5.02764482303386 4.73364088642803 0.294003936605834 0.337095845544187 0.807691985219911 0.374967097193454 0.872167190702727 0.364005019222501 0.477966853442896 NA NA NA 0.20446426522606 99.311357293691 a5518 gain_cnaBRCA9_(KRAS) 303 PIK-93 PI4K, PI3K 4 45 2.99573227355399 NA 2.30323412042395 2.83493102893369 -0.531696908509738 1.10959798330791 1.44374032718686 0.37318469587244 0.479179771870757 0.368277382364011 0.477988561922442 NA NA NA 0.422514825585406 99.311357293691 a5519 gain_cnaBRCA13_(FGFR1,WHSC1L1) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 10 35 -0.669430653942629 NA -2.99990019948772 -3.62513185900605 0.625231659518326 2.6824706572827 2.36685765955084 0.25663144945501 0.233080521429329 0.264161073225239 0.478038572140812 NA NA NA 0.516420056602241 99.311357293691 a5520 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1023 GW 441756 NTRK1 7 38 0.693147180559945 NA 2.68355961320663 2.29955232362673 0.384007289579901 1.03834389105393 1.34268624620354 0.294373633729683 0.369826695075105 0.285999272477606 0.478042775121376 NA NA NA 0.412069547671391 99.311357293691 a5521 POLR2B_mut 1378 Bleomycin (50 uM) DNA damage 3 45 3.91202300542815 NA 3.05724452657784 3.86308248561016 -0.805837959032326 4.05379385628345 1.72825488609655 0.426405691014612 0.198786121742048 0.46627263461838 0.478158649247785 NA NA NA 0.764100571064322 99.311357293691 a5522 loss_cnaBRCA33 1053 MK-2206 AKT1, AKT2 5 37 1.38629436111989 0.693147180559945 1.88923332430084 1.32693928643188 0.562294037868961 2.01660667574452 1.60249529443521 0.341074894788518 0.278831784418925 0.350886545390536 0.47825346426878 NA NA NA 0.577144032742517 99.311357293691 a5523 gain_cnaBRCA19 238 CAL-101 PI3Kdelta 4 45 2.99573227355399 2.32630161961136 4.39459053545576 4.74779743578547 -0.35320690032971 0.50907012380814 0.970053607322409 0.372834774881791 0.69382759626025 0.364110702401952 0.478399145989038 NA NA NA 0.279503700546275 99.311357293691 a5524 loss_cnaBRCA33 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 6 41 2.77258872223978 NA 4.73116313877751 5.0518388015712 -0.320675662793688 0.770698698459623 1.05457023047174 0.312271982496979 0.416084344549452 0.30408184635578 0.478659249744902 NA NA NA 0.392792066702966 99.311357293691 a5525 loss_cnaBRCA20 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 3 43 2.30258509299405 NA 1.81094250364753 1.38542368819021 0.425518815457321 0.589274471276113 1.01261398930887 0.426680450488811 0.722106312421496 0.420218187729905 0.478675233531307 NA NA NA 0.339934800762823 99.311357293691 a5526 gain_cnaBRCA31 45 Z-LLNle-CHO g-secretase 3 9 0.940007258491471 NA 1.5409156021431 0.786169000897556 0.754746601245541 1.76152125218073 1.47736289962704 0.49060514571438 0.428462955136749 0.510874207979688 0.478693003644023 NA NA NA 0.551872301172929 99.311357293691 a5527 loss_cnaBRCA22_(SYNCRIP,ZNF292) 235 QL-XII-47 BTK, BMX 19 30 2.32630161961136 NA 1.90118967381886 1.58576919478841 0.315420479030455 1.7907313080102 1.30047788049679 0.209276444874903 0.176140595531855 0.242541979191497 0.478897636513952 NA NA NA 0.511299155961603 99.311357293691 a5528 TP53_mut 200 LAQ824 HDAC 38 10 0.0237165266173161 NA -2.75918636921831 -2.40053536441836 -0.358651004799948 1.31677191414167 1.75671385889536 0.25370349589743 0.27237139625182 0.204160172690544 0.478935887334193 NA NA NA 0.558183778508617 99.311357293691 a5529 CDH1_mut 1494 SN-38 TOP1 5 43 -2.99573227355399 NA -2.79417860925757 -3.36304547511731 0.568866865859746 2.28700622748045 1.61826467577393 0.337211613733742 0.248738660622912 0.351528939842728 0.479033038441103 NA NA NA 0.614513558948681 99.311357293691 a5530 loss_cnaBRCA7_(FAS,PTEN) 178 BAY 61-3606 SYK 4 44 2.07944154167984 NA 3.64556723736634 3.04576969295981 0.599797544406533 1.28395295196673 1.63014705932511 0.372582055304817 0.467149161102654 0.367940757844787 0.479177478009284 NA NA NA 0.432881848437822 99.311357293691 a5531 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1239 YK 4-279 RNA helicase A 17 25 2.30258509299405 NA 2.18699332791967 1.89561337566556 0.291379952254116 1.4634006657941 1.17416418424896 0.224549799352153 0.199111534568013 0.248159461992528 0.479187740417348 NA NA NA 0.49893188759473 99.311357293691 a5532 loss_cnaBRCA36_(FAT1,IRF2) 1017 Olaparib PARP1, PARP2 8 37 1.6094379124341 NA 3.8701470387242 4.1181956241083 -0.248048585384096 0.78616555141466 0.910433021006273 0.278273306560561 0.315516986133196 0.272451217894025 0.479273359360327 NA NA NA 0.447961516995554 99.311357293691 a5533 loss_cnaBRCA20 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 40 1.6094379124341 NA 1.92842016093015 2.61526049044066 -0.686840329510512 0.586060224110207 1.64241258720101 0.427385591259008 1.17196202924932 0.418189884114942 0.479294491248948 NA NA NA 0.16869568036877 99.311357293691 a5534 POLR2B_mut 275 I-BET BRD2, BRD3, BRD4 3 46 2.99573227355399 NA 3.49568853427924 4.07437057183521 -0.57868203755597 1.06468676754706 1.37374925536497 0.424868240530637 0.543523273881951 0.421242839838503 0.479364728596501 NA NA NA 0.450091321690719 99.311357293691 a5535 gain_cnaBRCA15 254 AC220 FLT3 22 26 0.0237165266173161 NA 2.12477308483114 2.30752166151486 -0.182748576683727 0.813918865334824 0.940713799991449 0.206475642442913 0.224529230697398 0.194265861397364 0.479591512789799 NA NA NA 0.474230283564635 99.311357293691 a5536 BRCA2_mut 1219 PFI-1 BRD2, BRD3, BRD4 5 42 2.30258509299405 NA 2.87120209800191 3.2083476058221 -0.337145507820195 0.522168693751341 1.03490895697151 0.3371337491861 0.645663962345366 0.325773108396698 0.479754926264184 NA NA NA 0.265808231402396 99.311357293691 a5537 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1262 UNC1215 LMBL3 14 32 0 NA 2.85208917144024 2.71614643289813 0.135942738542114 0.585981341065808 0.599135136912003 0.228368091675404 0.231991582351165 0.226898290830973 0.479805418006757 NA NA NA 0.478684437467363 99.311357293691 a5538 gain_cnaBRCA14_(RAD21) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 21 27 2.07944154167984 NA 3.34994423333081 3.10880506441607 0.241139168914739 1.2540886000558 1.0886617668161 0.207256794859073 0.192282402458654 0.221500539713058 0.479859633345952 NA NA NA 0.488214831839921 99.311357293691 a5539 loss_cnaBRCA17 1046 681640 WEE1, CHEK1 6 30 0.693147180559945 NA 2.91849886997499 2.57685408632614 0.341644783648852 0.989450246129823 1.08254392665122 0.319484665318707 0.345287481594123 0.315594383967131 0.479862723884115 NA NA NA 0.470315821345095 99.311357293691 a5540 gain_cnaBRCA27_(CLTC,PPM1D) 260 NG-25 MAP3K7 (TAK1) 9 40 2.32630161961136 NA 3.48453313414888 3.14620071554377 0.33833241860511 1.18046351003226 1.30877170239435 0.262714084523528 0.286609806851094 0.258511410344633 0.479927378919161 NA NA NA 0.460404458210408 99.311357293691 a5541 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 292 Masitinib KIT 6 42 2.99573227355399 NA 4.30723371844232 3.96791219038298 0.339321528059344 0.896337478878551 1.11327516205463 0.31079518274805 0.378564476054136 0.304795741093426 0.479986112429848 NA NA NA 0.427518154385238 99.311357293691 a5542 TP53_mut 1001 AICAR AAPK1 (AMPK) agonist 35 10 7.60090245954208 NA 7.81701688187792 7.46361574407605 0.353401137801868 1.43780828502751 1.15737751753531 0.255380128390229 0.245791557526813 0.305346468587409 0.48017463179563 NA NA NA 0.431798352317256 99.311357293691 a5543 gain_cnaBRCA48 153 Midostaurin KIT 5 42 -0.669430653942629 NA 0.173539183416249 0.664403693256398 -0.490864509840149 1.47422969991173 1.45713101760841 0.336517653661182 0.332963384111405 0.336870538001315 0.480553554832066 NA NA NA 0.51260374429161 99.311357293691 a5544 MLL3_mut 1494 SN-38 TOP1 3 45 -2.99573227355399 NA -3.97435603202826 -3.25908400844994 -0.715272023578312 2.96181404136946 1.60522070864545 0.423980189175697 0.241497951453965 0.445591076495573 0.480651714667491 NA NA NA 0.71753611653727 99.311357293691 a5545 gain_cnaBRCA63 341 EX-527 SIRT1 7 42 2.99573227355399 NA 5.80491096461736 5.614560284488 0.190350680129361 0.80981918842493 0.630232262375297 0.290212116082469 0.235053309244977 0.302032586227725 0.480676824888305 NA NA NA 0.571372412993951 99.311357293691 a5546 loss_cnaBRCA18 1529 MLN4924 NEDD8-activating enzyme 13 24 0 NA 0.640518353447633 0.222259436755032 0.418258916692601 1.58204180858133 1.7642593721502 0.245459802070804 0.264379180388202 0.237073371010547 0.480705980943036 NA NA NA 0.467537175708022 99.311357293691 a5547 PIK3CA_mut 211 TL-2-105 CRAF 17 32 2.32630161961136 1.63315443905142 3.7556273759838 3.98826461555436 -0.232637239570562 0.966294662456322 1.14943182849462 0.213321902385356 0.240751862355525 0.202393246648861 0.480731402144429 NA NA NA 0.457869446753386 99.311357293691 a5548 loss_cnaBRCA36_(FAT1,IRF2) 1495 AZD-2281 PARP1, PARP2 9 36 2.30258509299405 NA 3.75854634759239 4.05872753429605 -0.300181186703659 0.65507331148451 1.21547380812874 0.265081728535352 0.458240599091721 0.246966396722113 0.480746154410714 NA NA NA 0.323732735354206 99.311357293691 a5549 loss_cnaBRCA20 1371 PLX4720 (rescreen) BRAF 3 44 2.30258509299405 NA 5.08782331572195 4.68119216387297 0.40663115184898 0.29392547699287 0.97843590633235 0.424258709533624 1.38344983228128 0.415593039071133 0.480754278861343 NA NA NA 0.120488860000765 99.311357293691 a5550 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1020 Lenalidomide TNFA 6 39 1.6094379124341 NA 4.06233338008819 4.28432553023737 -0.221992150149179 0.881143869246806 0.686514666153355 0.311837005941085 0.251936327195848 0.323361118259911 0.480863381231286 NA NA NA 0.576712909124469 99.311357293691 a5551 gain_cnaBRCA8_(CHD4,WNK1) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 4 44 2.32630161961136 NA 4.72128049015989 4.98005494105148 -0.258774450891588 1.13383066515841 0.656115183466515 0.371099192292753 0.228230245347469 0.394403997060974 0.480919087883592 NA NA NA 0.681802093182278 99.311357293691 a5552 gain_cnaBRCA62 136 Mitomycin C DNA crosslinker 9 39 2.77258872223978 NA 0.182045954288421 -0.207309418025757 0.389355372314178 1.69400338307122 1.43302192082478 0.262773327369623 0.22984332629152 0.271702314288453 0.480930645295839 NA NA NA 0.536267822637117 99.311357293691 a5553 loss_cnaBRCA36_(FAT1,IRF2) 1239 YK 4-279 RNA helicase A 9 33 2.30258509299405 NA 1.74081065224944 2.08793712412207 -0.347126471872632 0.967086776910308 1.3679082112095 0.267496450238931 0.358940355881659 0.253764447810211 0.481007149540795 NA NA NA 0.39794539987999 99.311357293691 a5554 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 291 KIN001-266 MAP3K8 (COT) 15 34 2.99573227355399 NA 3.9592456339464 3.69895298617444 0.260292647771964 1.07782699225112 1.22397798271818 0.220151469657153 0.241497614777974 0.212661217315293 0.481061184013869 NA NA NA 0.460989286413306 99.311357293691 a5555 loss_cnaBRCA20 1049 PD-173074 FGFR1, FGFR3 3 40 0.693147180559945 NA 3.39126623770455 2.90375132131382 0.487514916390734 0.533061219408932 1.16821349447902 0.425617019817825 0.914557087704296 0.417316628077601 0.481103929772324 NA NA NA 0.25176633174492 99.311357293691 a5556 PTEN_mut 1053 MK-2206 AKT1, AKT2 6 36 1.38629436111989 0.693147180559945 0.950719664103536 1.46773895096841 -0.517019286864872 1.85747820107249 1.61671013158221 0.313586375055848 0.27834473996322 0.319797146541592 0.48111974343646 NA NA NA 0.54314367243233 99.311357293691 a5557 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 6 37 1.6094379124341 NA 3.35205011696261 2.88004548614771 0.472004630814903 1.49990649339429 1.51013787003144 0.312814999598481 0.314689370899885 0.312557310283911 0.48125001387829 NA NA NA 0.498950321655896 99.311357293691 a5558 CDH1_mut 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 38 -1.38629436111989 0.693147180559945 0.272402345209392 -0.362726328183922 0.635128673393314 0.772821226462661 1.75373180430665 0.373624427092371 0.821831300235386 0.362158382389841 0.481347526884417 NA NA NA 0.227403301339779 99.311357293691 a5559 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 134 Etoposide TOP2 14 33 2.77258872223978 NA 2.82112617940685 2.33115191646692 0.489974262939931 2.36769004951622 2.07514415313068 0.226449518245389 0.206941893868265 0.236115771620361 0.481382325146386 NA NA NA 0.508328155685265 99.311357293691 a5560 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1529 MLN4924 NEDD8-activating enzyme 16 21 0 NA 0.597597970021908 0.195209407456641 0.402388562565267 1.89571254752284 1.54472064249749 0.236140538891586 0.212262435616136 0.260492772281911 0.481425415874349 NA NA NA 0.494598084245564 99.311357293691 a5561 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 263 FR-180204 ERK 15 34 2.99573227355399 NA 5.24579922424023 5.40733444751509 -0.161535223274857 0.524544869054161 0.80744997992301 0.219876818938338 0.307953109075552 0.200056012497838 0.481605638681689 NA NA NA 0.40925741524352 99.311357293691 a5562 gain_cnaBRCA14_(RAD21) 1371 PLX4720 (rescreen) BRAF 21 26 2.30258509299405 NA 4.81752379972246 4.61799712936172 0.199526670360741 0.779897625849365 1.08028443961136 0.208171414916004 0.255837001867318 0.184698273014579 0.481658346829634 NA NA NA 0.46666275826617 99.311357293691 a5563 CDH1_mut 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 41 2.30258509299405 NA 3.61900633341932 3.13373143136972 0.48527490204961 0.563364467563829 1.34447959769987 0.371789428447337 0.861387130338723 0.360938836766147 0.481683128164342 NA NA NA 0.209131334989274 99.311357293691 a5564 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1023 GW 441756 NTRK1 6 39 0.693147180559945 NA 2.71118940125198 2.30514792776283 0.40604147348915 0.646406699396826 1.36784420127364 0.31123417993179 0.628151709857022 0.296847749993072 0.481706954465958 NA NA NA 0.25696804131874 99.311357293691 a5565 gain_cnaBRCA63 135 Gemcitabine DNA replication 5 42 0.0237165266173161 NA 0.555169704835238 -0.374080090993022 0.92924979582826 3.47029144767296 2.69123588086443 0.335545067091367 0.267772839785943 0.345287383553233 0.481815816035663 NA NA NA 0.590191447415244 99.311357293691 a5566 ASH1L_mut 163 JQ1 BRD4 3 44 0.940007258491471 NA -0.263070027484374 0.355393115407165 -0.618463142891539 2.09402151772731 1.42515857023752 0.423198836480665 0.295347081038007 0.433960933054956 0.481844991998312 NA NA NA 0.661825222790031 99.311357293691 a5567 gain_cnaBRCA16 261 TL-1-85 MAP3K7 (TAK1) 16 33 2.32630161961136 NA 4.20143335145867 3.93916918811678 0.262264163341885 1.44817200119785 1.08776025343211 0.215950894385826 0.181100147720681 0.241104749428366 0.481899311926363 NA NA NA 0.527145729162869 99.311357293691 a5568 loss_cnaBRCA29_(MAP2K4) 1028 VX-702 p38 6 39 0.693147180559945 NA 3.24205697313809 3.45525827159973 -0.213201298461644 0.782855450257465 0.671444104391647 0.31109285307785 0.272338013858787 0.317526503050931 0.481904842765628 NA NA NA 0.549853787483967 99.311357293691 a5569 loss_cnaBRCA38 166 FTI-277 Farnesyl transferase (FNTA) 4 43 0.0237165266173161 NA 1.9674468541657 2.27014987538109 -0.302703021215393 0.72813740193762 0.822791578165135 0.370585993780089 0.415722390320675 0.367897568774872 0.482023793811294 NA NA NA 0.478499233614709 99.311357293691 a5570 loss_cnaBRCA33 94 TGX221 PI3Kbeta 5 9 2.30258509299405 NA 4.10439654892506 3.58293059121589 0.521465957709175 0.691997944605853 1.50041940369213 0.404680095086499 0.75356576095929 0.347546796866253 0.482038483853014 NA NA NA 0.392944731745398 99.311357293691 a5571 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 7 42 1.63315443905142 NA 3.82511007376366 3.53524803559854 0.289862038165114 1.30959198780541 0.948724962878579 0.289267409906777 0.221337669185698 0.305527997582806 0.482098805667935 NA NA NA 0.591721922867234 99.311357293691 a5572 gain_cnaBRCA19 135 Gemcitabine DNA replication 4 43 0.0237165266173161 NA 0.663537769705198 -0.362550380845385 1.02608815055058 3.70067749232742 2.69056830998686 0.37050986925006 0.277270351895825 0.381364839072082 0.482113299068717 NA NA NA 0.622657333283001 99.311357293691 a5573 gain_cnaBRCA27_(CLTC,PPM1D) 257 NPK76-II-72-1 PLK3 9 40 2.32630161961136 NA 3.81772903111016 3.40273733190908 0.414991699201085 1.49112369094723 1.60719620315473 0.26132346120578 0.278308031533899 0.25820848654726 0.482242801327869 NA NA NA 0.470925698887292 99.311357293691 a5574 gain_cnaBRCA27_(CLTC,PPM1D) 1143 HG-5-88-01 EGFR, ADCK4 7 19 2.30258509299405 NA 4.76058228987336 4.45062774747083 0.309954542402529 0.846257682759131 1.02352508242081 0.315567814621646 0.366264967181102 0.302830431540998 0.482280040667526 NA NA NA 0.448753817907904 99.311357293691 a5575 BRCA2_mut 256 JW-7-24-1 LCK 6 42 2.32630161961136 NA 1.52208293763906 1.88263858449691 -0.360555646857847 0.778629722690571 1.20507952513338 0.309143763703203 0.463064324865405 0.299196558681836 0.482309973270538 NA NA NA 0.353466659974416 99.311357293691 a5576 gain_cnaBRCA58_(CCND1) 1047 Nutlin-3a MDM2 8 35 2.07944154167984 1.38629436111989 4.43477546476103 4.15486893452658 0.279906530234452 0.978205721057857 1.01347901094335 0.277810680625433 0.286142806373852 0.276183845163122 0.482389440388378 NA NA NA 0.48383101315422 99.311357293691 a5577 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1219 PFI-1 BRD2, BRD3, BRD4 18 29 2.30258509299405 NA 3.04133842374703 3.25387994162384 -0.212541517876804 0.846902866876032 1.08259177810908 0.212519571061922 0.25096327594309 0.196326558333965 0.482444095257802 NA NA NA 0.457256622513497 99.311357293691 a5578 loss_cnaBRCA22_(SYNCRIP,ZNF292) 299 OSI-027 MTORC1/2 18 30 2.99573227355399 NA 1.00652659117754 1.42643534710218 -0.419908755924638 2.30694868576392 1.77661291713547 0.211099916219165 0.182019114042665 0.236353542110726 0.482486309639264 NA NA NA 0.512420155542776 99.311357293691 a5579 PTEN_mut 1004 Vinblastine Microtubules 7 38 -2.30258509299405 NA -3.77202385296347 -3.39726444825048 -0.374759404712987 0.570097433643131 1.36747116579443 0.291361516180618 0.657360273169689 0.274052875180934 0.482531524668241 NA NA NA 0.238716099688615 99.311357293691 a5580 loss_cnaBRCA29_(MAP2K4) 1007 Docetaxel Microtubules 6 39 -4.38202663467388 NA -4.17085209940891 -4.6513454333915 0.480493333982583 1.43931218125536 1.56054675400721 0.31060931247647 0.333835383484005 0.307900633382986 0.482582250747586 NA NA NA 0.476482637441419 99.311357293691 a5581 TP53_mut 1038 NU-7441 PRKDC (DNAPK) 34 9 0.693147180559945 NA 2.94550638737154 2.69399761147808 0.251508775893462 0.924088435974218 1.03645095390326 0.265567878913576 0.272169595573728 0.242663461253313 0.482681753906919 NA NA NA 0.521098939131821 99.311357293691 a5582 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 184 BMS-754807 IGF1R 9 39 0.940007258491471 NA 1.98447718144823 1.5443439792718 0.440133202176429 1.05291941842913 1.78666136681562 0.261640925086142 0.418012237663043 0.246343940911915 0.482812880679897 NA NA NA 0.34249556899132 99.311357293691 a5583 loss_cnaBRCA33 228 KIN001-102 AKT1 6 43 2.32630161961136 NA 2.32507618521899 1.89048881608632 0.434587369132671 0.282933750770135 1.48806364563169 0.308281408332779 1.53600398662139 0.292048912295136 0.48281692984077 NA NA NA 0.0951589798807867 99.311357293691 a5584 gain_cnaBRCA64_(SDHC) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 7 35 1.38629436111989 0.693147180559945 3.68922814862677 3.38227011815149 0.306958030475278 1.19974655227501 1.01739205622934 0.29324239156507 0.255852396402566 0.30171066168231 0.482898546406823 NA NA NA 0.54483224935639 99.311357293691 a5585 BRCA1_mut 1023 GW 441756 NTRK1 4 41 0.693147180559945 NA 1.91871739735469 2.40226917075228 -0.48355177339759 0.548378784500342 1.34434124157575 0.370633381640213 0.881784246701265 0.359694219326934 0.483039148588517 NA NA NA 0.202166309910172 99.311357293691 a5586 ARID1A_mut 222 BX-912 PDPK1 (PDK1) 5 44 2.32630161961136 NA 4.33767841977366 3.83220150260801 0.505476917165646 0.613684636929264 1.57274031470606 0.333660687201364 0.823675364752384 0.321398842796318 0.483058324931898 NA NA NA 0.18953240138907 99.311357293691 a5587 PTEN_mut 177 GSK-650394 SGK3 7 40 2.77258872223978 NA 3.59547545886197 4.08775739789859 -0.492281939036613 1.16027710945757 1.76810449203846 0.289634403237266 0.424279626844277 0.278423555425199 0.483250972576317 NA NA NA 0.36320566637755 99.311357293691 a5588 gain_cnaBRCA16 1009 ATRA Retinoic acid and retinoid X receptor agonist 15 30 2.30258509299405 NA 4.27890016292572 4.01950622591587 0.259393937009852 1.34219959613266 1.06095170401941 0.223609407928622 0.19326033010087 0.244491748330428 0.483309729099821 NA NA NA 0.519994167877494 99.311357293691 a5589 gain_cnaBRCA8_(CHD4,WNK1) 1164 XMD8-92 MAP2K5 (ERK5) 3 23 2.30258509299405 NA 3.37904652858451 3.95041626389819 -0.57136973531368 0.723930563519899 1.34802079816944 0.437013646775797 0.789260412677651 0.42385824913798 0.483376191964735 NA NA NA 0.317999449787656 99.311357293691 a5590 gain_cnaBRCA62 273 CUDC-101 HDAC, EGFR 10 39 1.63315443905142 NA 0.286633226912535 -0.106977162117076 0.393610389029611 2.60451124473877 1.2040563898627 0.25039235260257 0.151126392648418 0.326903617092631 0.483422102490568 NA NA NA 0.651661685786842 99.311357293691 a5591 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1001 AICAR AAPK1 (AMPK) agonist 17 28 7.60090245954208 NA 7.55132119386326 7.85211742895757 -0.300796235094311 1.47455040461314 1.32733648129659 0.217347065493684 0.2039918297491 0.226616415153814 0.483449001136413 NA NA NA 0.496181168295048 99.311357293691 a5592 gain_cnaBRCA15 201 Epothilone B Microtubules 22 26 -3.44201937618241 NA -4.03553261068469 -4.40517934438631 0.369646733701615 2.03119145607425 1.59757098152851 0.204397216062844 0.181985175546201 0.231380475719424 0.484001248780997 NA NA NA 0.493241884346045 99.311357293691 a5593 PIK3CA_mut 152 CP466722 ATM 17 32 2.77258872223978 NA 2.58315936707604 2.80822615727787 -0.225066790201826 0.877846680887461 1.14778108430574 0.21160696284238 0.256385078513134 0.196088603723559 0.484247231604793 NA NA NA 0.448517668855206 99.311357293691 a5594 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 231 FMK RSK 7 42 2.99573227355399 2.32630161961136 5.7359267228455 5.56478019312117 0.171146529724332 1.00596139254139 0.507252074024777 0.287796361931103 0.170132304274579 0.337399369048164 0.484317734277725 NA NA NA 0.673548821774099 99.311357293691 a5595 loss_cnaBRCA18 208 SB-715992 KIF11 16 33 -2.05572501506252 NA -1.4874234561329 -1.1198875635351 -0.367535892597803 1.25670307364948 1.88760647950655 0.214718786260609 0.292460407159247 0.194710018527741 0.484389753632214 NA NA NA 0.423373560385974 99.311357293691 a5596 loss_cnaBRCA38 329 QL-XI-92 DDR1 4 44 2.32630161961136 NA 3.93323819704168 4.28243481647911 -0.349196619437422 0.70192078066831 0.963597247182712 0.368065893211774 0.497487222283043 0.362388560633994 0.484492738418739 NA NA NA 0.408670500115082 99.311357293691 a5597 loss_cnaBRCA57 165 DMOG Prolyl-4-Hydroxylase 5 41 8.29404964010203 NA 8.02796735677362 7.51412853167422 0.513838825099403 1.18551028908606 1.56952594133416 0.333969271396226 0.433432615330175 0.327384729087445 0.484510275633129 NA NA NA 0.413597183052489 99.311357293691 a5598 POLR2B_mut 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 42 2.30258509299405 NA 3.69013043295087 3.14020530288055 0.549925130070321 1.32314411954419 1.30446887150604 0.421287704759563 0.41561997816214 0.421570144050599 0.484643016487186 NA NA NA 0.550363972109204 99.311357293691 a5599 gain_cnaBRCA63 300 CX-5461 RNA Pol I 7 42 2.32630161961136 NA 3.49045489480425 3.9826836929603 -0.492228798156058 1.9793228032047 1.66890739169105 0.287571863604557 0.248685458157252 0.294940750221795 0.484656869499048 NA NA NA 0.552314188684659 99.311357293691 a5600 gain_cnaBRCA64_(SDHC) 205 BMS-708163 g-secretase 8 40 2.32630161961136 0.940007258491471 4.74184724302066 4.92746597253942 -0.185618729518757 0.531683209184237 0.703901930116335 0.272763309098305 0.349115274495037 0.263699702440196 0.484813825464833 NA NA NA 0.411487916742017 99.311357293691 a5601 loss_cnaBRCA60 265 Tubastatin A HDAC6 3 46 2.99573227355399 NA 4.28321121044934 4.71840394654732 -0.435192736097979 0.695741223830479 1.04987341108872 0.419555953343621 0.62550948713658 0.414519247274473 0.484847565384819 NA NA NA 0.395678253528427 99.311357293691 a5602 loss_cnaBRCA17 1066 AZD6482 PI3Kbeta 8 35 1.6094379124341 NA 2.29137311560199 1.89308810023726 0.39828501536473 1.71481918520875 1.37911595868212 0.27620809609262 0.232260648119729 0.288797336335178 0.484904118803745 NA NA NA 0.554648074865505 99.311357293691 a5603 NF1_mut 221 TAK-715 p38a 5 44 2.99573227355399 2.32630161961136 4.78311936429061 4.44795195816891 0.335167406121701 0.853596088576891 1.02204712619125 0.332241510115553 0.39265339966645 0.327937330415216 0.484911778209072 NA NA NA 0.449965454861546 99.311357293691 a5604 gain_cnaBRCA9_(KRAS) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 4 43 2.32630161961136 NA 1.93428651100679 1.3688106728283 0.565475838178496 2.66378206568638 1.42177120196557 0.368115246405773 0.212283071300275 0.397726327131072 0.484933598100531 NA NA NA 0.702038522622393 99.311357293691 a5605 loss_cnaBRCA17 9 MG-132 Proteasome 4 10 0 NA 0.816848809296419 0.13404629608793 0.682802513208488 1.59640522297646 1.60338748315942 0.426313328182963 0.42771252773492 0.42584997100205 0.484956452621898 NA NA NA 0.499254598784001 99.311357293691 a5606 PTEN_mut 153 Midostaurin KIT 8 39 -0.669430653942629 NA 0.281357062170405 0.68004601375607 -0.398688951585665 1.58452321054321 1.43446559421667 0.273295129588633 0.251614459752209 0.277935527483585 0.484972433769148 NA NA NA 0.525866720625978 99.311357293691 a5607 gain_cnaBRCA62 1175 AG-014699 PARP1, PARP2 7 36 1.6094379124341 NA 4.11228376055922 3.81282087677399 0.299462883785232 1.38162430693624 0.955545168287577 0.291029367341349 0.216746971142461 0.313394796733572 0.485082331562273 NA NA NA 0.600020701049656 99.311357293691 a5608 loss_cnaBRCA38 1046 681640 WEE1, CHEK1 3 33 0.693147180559945 NA 2.21666457780574 2.67171582049142 -0.455051242685678 0.833261030523568 1.08261415531946 0.42545777566024 0.546108873470001 0.42032633736569 0.485279275147191 NA NA NA 0.450832334034021 99.311357293691 a5609 PIK3CA_mut 257 NPK76-II-72-1 PLK3 17 32 2.32630161961136 NA 3.6978281348701 3.36268675823634 0.335141376633758 1.48757331859446 1.63766171005341 0.211024811924197 0.225294022448868 0.20464627986132 0.485443973823719 NA NA NA 0.473488171160131 99.311357293691 a5610 loss_cnaBRCA28_(GPS2) 1050 ZM-447439 AURKB 3 36 1.38629436111989 0.693147180559945 3.40398102181081 2.8449193365381 0.559061685272715 0.31833059866085 1.35570390705132 0.423329622767665 1.75622980519174 0.412377424277463 0.485555174146224 NA NA NA 0.0808500758351313 99.311357293691 a5611 TP53_mut 135 Gemcitabine DNA replication 37 10 0.0237165266173161 NA -0.127561366902648 -0.821574472213277 0.694013105310629 2.65140165218874 3.19919134020788 0.25057875000918 0.261753289901483 0.216933915951877 0.4856361891627 NA NA NA 0.539991771094825 99.311357293691 a5612 gain_cnaBRCA8_(CHD4,WNK1) 261 TL-1-85 MAP3K7 (TAK1) 4 45 2.32630161961136 NA 4.43376240149285 3.98845482722714 0.445307574265715 1.39489281898565 1.20129373241568 0.366637000360891 0.319241427158208 0.370690000496587 0.485704251219718 NA NA NA 0.575202617951859 99.311357293691 a5613 gain_cnaBRCA48 344 THZ-2-49 CDK9 5 44 2.99573227355399 NA 1.34548701193088 1.83525090258485 -0.489763890653968 1.40328207176355 1.48371653309925 0.331584361502214 0.34901314604445 0.330092628698374 0.485771363138476 NA NA NA 0.494824413397192 99.311357293691 a5614 loss_cnaBRCA38 1248 FK866 NAMPT 3 41 0 NA 0.415414095784098 -0.7287146483771 1.1441287441612 3.10766014513835 2.69967356416027 0.420559918748145 0.368164049711511 0.423802625380406 0.485835837667431 NA NA NA 0.592347750463543 99.311357293691 a5615 gain_cnaBRCA14_(RAD21) 290 KIN001-260 IKK 21 28 2.99573227355399 NA 4.92307873512896 5.13481980992354 -0.211741074794588 1.39820788153749 0.670705020102977 0.202780440357857 0.1514374776387 0.31569925443838 0.485861940609457 NA NA NA 0.527026280916838 99.311357293691 a5616 gain_cnaBRCA14_(RAD21) 203 BMS-345541 IKBKB 21 28 2.77258872223978 NA 3.41526712004166 3.62013091448422 -0.204863794442565 1.1249753920447 0.916335277210692 0.202755545955696 0.18210513393561 0.223568599329894 0.485915209979528 NA NA NA 0.499435618513437 99.311357293691 a5617 gain_cnaBRCA13_(FGFR1,WHSC1L1) 71 Pyrimethamine Dihydrofolate reductase (DHFR) 4 10 2.99573227355399 NA 4.26205744384757 4.69255600207284 -0.43049855822527 1.17431190013658 0.952202038707136 0.425264162269316 0.366596436751769 0.452108418933638 0.486009423252108 NA NA NA 0.544829565118093 99.311357293691 a5618 gain_cnaBRCA10_(MDM2,NUP107) 224 AS605240 PI3Kgamma 5 44 2.99573227355399 2.32630161961136 3.74158509496932 3.21669671004597 0.524888384923351 0.913142517287695 1.63259308640267 0.331340590604047 0.57481540393325 0.321505946150925 0.486090444554415 NA NA NA 0.30573351928322 99.311357293691 a5619 gain_cnaBRCA8_(CHD4,WNK1) 269 NSC-207895 MDM4 4 45 2.99573227355399 NA 5.00439744956062 4.56834639504471 0.436051054515909 1.89331048592847 1.12676849645574 0.3662646988492 0.230311434789351 0.386992586221139 0.48614504578817 NA NA NA 0.679236544093636 99.311357293691 a5620 gain_cnaBRCA15 282 EKB-569 EGFR 21 26 0.916290731874155 2.99573227355399 1.3364056510253 1.7732558298201 -0.436850178794798 2.30935513395181 1.95667180110169 0.205995956443723 0.189165439465022 0.223261856458929 0.486225550830449 NA NA NA 0.494445513520627 99.311357293691 a5621 gain_cnaBRCA13_(FGFR1,WHSC1L1) 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 4 10 1.38629436111989 NA 2.16643569334791 1.82224285410839 0.34419283923952 1.07451415355904 0.700251479835209 0.424829316427197 0.320324155898247 0.491527471417153 0.486446255030189 NA NA NA 0.585009013387848 99.311357293691 a5622 gain_cnaBRCA13_(FGFR1,WHSC1L1) 271 VNLG/124 HDAC, RAR 11 38 1.63315443905142 NA 3.99964319696594 4.19538131603364 -0.195738119067699 0.978358405133313 0.764857897123544 0.240175018238506 0.200067907671348 0.255914359783465 0.486459940111036 NA NA NA 0.550762129076065 99.311357293691 a5623 gain_cnaBRCA48 1036 PLX4720 BRAF 4 39 2.30258509299405 NA 4.19357202262058 4.63795349019277 -0.444381467572186 1.11336365410586 1.21225792430384 0.368690449863246 0.399134160643199 0.366573365834981 0.486492977525797 NA NA NA 0.495331742943333 99.311357293691 a5624 loss_cnaBRCA17 1495 AZD-2281 PARP1, PARP2 9 36 2.30258509299405 NA 4.23571629915118 3.93943504640636 0.296281252744819 0.543474071120491 1.22818082009637 0.261598078964881 0.545161707777467 0.241235857047151 0.486498041042586 NA NA NA 0.286984273958738 99.311357293691 a5625 gain_cnaBRCA14_(RAD21) 1010 Gefitinib EGFR 20 25 -0.693147180559945 NA 1.27777300786062 1.49759766013315 -0.219824652272532 1.02947499896724 1.05565483546253 0.21052614536988 0.213530831242195 0.208235348229346 0.486613800466695 NA NA NA 0.48553307438298 99.311357293691 a5626 loss_cnaBRCA7_(FAS,PTEN) 1259 BMN-673 PARP1 4 42 2.30258509299405 NA 2.78241242963715 3.35535952724512 -0.572947097607964 1.74747221263848 1.54604795425507 0.367130813167248 0.327871936082395 0.370588180030952 0.486616286280408 NA NA NA 0.566337912221254 99.311357293691 a5627 loss_cnaBRCA33 86 A-443654 AKT1, AKT2, AKT3 4 8 0.0237165266173161 NA -0.902596835238865 -1.46139598789374 0.558799152654874 1.51361279949213 1.13962862350058 0.442262572478371 0.369182364764866 0.490334430999478 0.48670958595983 NA NA NA 0.544606439894296 99.311357293691 a5628 loss_cnaBRCA33 17 Cyclopamine SMO 4 9 2.77258872223978 NA 4.94447482041957 4.58504720284428 0.35942761757529 0.291789137842466 0.957995603451946 0.432487307724835 1.23180602346253 0.37518712641286 0.48671854111741 NA NA NA 0.3290112604224 99.311357293691 a5629 loss_cnaBRCA7_(FAS,PTEN) 1022 AZD7762 CHEK1, CHEK2 4 41 0.693147180559945 NA 0.360510477866115 0.957847291252788 -0.597336813386673 1.45445222433608 1.63880396837652 0.367225710476798 0.410695383039715 0.36449558636255 0.487048739975812 NA NA NA 0.484002992045796 99.311357293691 a5630 gain_cnaBRCA16 272 AR-42 HDAC 16 33 1.63315443905142 NA -0.0783596745936067 0.248794460260888 -0.327154134854495 1.89558753338131 1.33014007435978 0.21334856983542 0.172587194784366 0.245954648807917 0.487167789070823 NA NA NA 0.541335757250307 99.311357293691 a5631 gain_cnaBRCA27_(CLTC,PPM1D) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 10 32 1.38629436111989 0.693147180559945 3.63604870893144 3.37011137769923 0.265937331232216 1.05478258906792 1.04460201388743 0.254023313935322 0.252125256890348 0.254582441634919 0.487255695236016 NA NA NA 0.496174319302889 99.311357293691 a5632 BRCA1_mut 221 TAK-715 p38a 4 45 2.99573227355399 2.32630161961136 4.82057653768643 4.45207059622532 0.368505941461106 1.19069370159108 0.995258429960443 0.365267911173411 0.309488444398998 0.370261562593097 0.487326313049279 NA NA NA 0.585979769601968 99.311357293691 a5633 gain_cnaBRCA62 1091 BMS-536924 IGF1R 8 39 1.38629436111989 NA 3.27067847268626 2.97255837232437 0.298120100361897 0.929408927352861 1.12515306226616 0.271759336306918 0.320763112541862 0.264959595596226 0.487416110017254 NA NA NA 0.442220618864935 99.311357293691 a5634 gain_cnaBRCA8_(CHD4,WNK1) 344 THZ-2-49 CDK9 4 45 2.99573227355399 NA 1.28992549463877 1.82930606210739 -0.539380567468617 1.48861242738504 1.47631274002817 0.365161630056012 0.362337810397107 0.365356575774266 0.48745235836063 NA NA NA 0.529924620569242 99.311357293691 a5635 loss_cnaBRCA20 178 BAY 61-3606 SYK 3 45 2.07944154167984 NA 3.72579369190262 3.05375009697753 0.672043594925086 1.24748930905507 1.62473303159338 0.417374304227832 0.538716917288963 0.413633244266605 0.487478556773426 NA NA NA 0.453862916866288 99.311357293691 a5636 loss_cnaBRCA7_(FAS,PTEN) 326 GSK690693 AKT 4 44 2.32630161961136 NA 3.58759744139547 2.88066741497427 0.706930026421195 1.10109971511386 1.97920946334462 0.365502458079011 0.642021804853612 0.357177974092025 0.48752437883821 NA NA NA 0.310255667217713 99.311357293691 a5637 gain_cnaBRCA58_(CCND1) 175 PAC-1 CASP3 agonist 9 39 0.940007258491471 NA 2.65895722086256 2.34194131893247 0.317015901930099 1.1654447759873 1.23767877544075 0.258699321219126 0.27201280443472 0.256137463306831 0.487721561225638 NA NA NA 0.480645273315217 99.311357293691 a5638 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 271 VNLG/124 HDAC, RAR 9 40 1.63315443905142 NA 3.97979036243849 4.19006129784893 -0.210270935410433 0.696575193464457 0.837232885496157 0.257998840868456 0.301863944313949 0.251149876041746 0.487803700665157 NA NA NA 0.444798893455292 99.311357293691 a5639 BRCA1_mut 1028 VX-702 p38 4 41 0.693147180559945 NA 3.65575592307246 3.40449733509581 0.251258587976655 0.356175465428078 0.703950129360435 0.366567119068304 0.705434855471232 0.356926687697228 0.487825803593068 NA NA NA 0.277748342485295 99.311357293691 a5640 NF1_mut 172 Embelin XIAP 5 43 3.46573590279973 NA 2.70597103010077 3.0264448716217 -0.320473841520927 0.451445123357591 1.00553859319381 0.330384102067597 0.709884380049177 0.318708643994492 0.487931342800126 NA NA NA 0.235910328303194 99.311357293691 a5641 loss_cnaBRCA22_(SYNCRIP,ZNF292) 179 5-Fluorouracil DNA antimetabolite 19 30 3.46573590279973 NA 4.24500002939905 3.91257857186873 0.332421457530328 1.5651576222031 1.65607257537668 0.204963564822597 0.212388485871739 0.200728798044806 0.487958108331795 NA NA NA 0.482945751613564 99.311357293691 a5642 gain_cnaBRCA64_(SDHC) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 9 37 1.38629436111989 NA 2.54822629743646 2.93410779853099 -0.385881501094521 2.53853117707846 1.12366534084169 0.259882753726481 0.152009754530029 0.343413191694133 0.488087771033673 NA NA NA 0.66671950904978 99.311357293691 a5643 gain_cnaBRCA64_(SDHC) 312 AV-951 VEGFR 8 40 -2.05572501506252 NA 0.777257232158796 0.603279571668461 0.173977660490334 0.851700680782668 0.597997449951923 0.2705323800548 0.204270895181694 0.290933783253292 0.488373836526571 NA NA NA 0.595774750571933 99.311357293691 a5644 BRCA1_mut 1230 IOX2 EGLN1 4 43 -2.30258509299405 NA 0.468421403252066 0.229094461989023 0.239326941263043 0.25434863148647 0.674929927928969 0.365193341592935 0.940940550237537 0.354595242201544 0.488387388089939 NA NA NA 0.181788716689791 99.311357293691 a5645 gain_cnaBRCA10_(MDM2,NUP107) 206 Ruxolitinib JAK1, JAK2, TYK2 5 44 1.65632149833295 0.0237165266173161 4.56406992068776 4.34823664910854 0.215833271579217 0.366806915134754 0.675465087238139 0.329574499049276 0.588411130417009 0.319532831018287 0.488405642904425 NA NA NA 0.297834983596277 99.311357293691 a5646 gain_cnaBRCA27_(CLTC,PPM1D) 226 GSK1070916 AURKB 9 40 0.940007258491471 2.32630161961136 2.81444816290144 2.31158510712851 0.502863055772937 2.11976814852543 1.91604034334282 0.257585317129341 0.237225498516308 0.262449095876351 0.488497867090199 NA NA NA 0.52633234569314 99.311357293691 a5647 gain_cnaBRCA14_(RAD21) 228 KIN001-102 AKT1 21 28 2.32630161961136 NA 1.78132992959939 2.06548384576565 -0.284153916166267 1.4789353242673 1.35650400224211 0.201541536512425 0.192134105869061 0.209475177144041 0.488516916805687 NA NA NA 0.494426755551052 99.311357293691 a5648 PTEN_mut 1164 XMD8-92 MAP2K5 (ERK5) 4 22 2.30258509299405 NA 3.46135031115939 3.96142329139883 -0.500072980239445 0.685449003287647 1.37383949641665 0.382389020620987 0.729555339406614 0.363996654298971 0.488517608280891 NA NA NA 0.298271765298786 99.311357293691 a5649 loss_cnaBRCA7_(FAS,PTEN) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 4 39 1.6094379124341 NA 3.34415148299347 2.81911869578988 0.525032787203588 0.86262186559775 1.46639273604066 0.366930167373111 0.608647668396128 0.358043772517045 0.488563956501266 NA NA NA 0.333821551277205 99.311357293691 a5650 BRCA1_mut 1241 CHIR-99021 GSK3B 4 42 2.30258509299405 NA 3.90453391775341 4.26262549008061 -0.358091572327208 0.789571929316228 0.992499908797823 0.365399691910543 0.453526219754692 0.360797587136255 0.488662118816506 NA NA NA 0.445767468704839 99.311357293691 a5651 loss_cnaBRCA22_(SYNCRIP,ZNF292) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 18 30 0.246860077931526 2.32630161961136 -0.480457905605263 -0.135648250818245 -0.344809654787018 1.68580453679889 1.64014796618496 0.208071686447882 0.204537149628131 0.210230821789241 0.48875661195733 NA NA NA 0.492853343055711 99.311357293691 a5652 gain_cnaBRCA9_(KRAS) 238 CAL-101 PI3Kdelta 4 45 2.99573227355399 2.32630161961136 5.03572864888652 4.69080738125829 0.344921267628228 0.615529699361402 0.966086902354441 0.36399703569153 0.560364947436454 0.357029234934895 0.488834711872623 NA NA NA 0.362109307136596 99.311357293691 a5653 gain_cnaBRCA27_(CLTC,PPM1D) 179 5-Fluorouracil DNA antimetabolite 9 40 3.46573590279973 NA 4.38218072142758 3.96481828054489 0.417362440882687 1.65689253858226 1.61462057197341 0.257330344511853 0.25189469513805 0.258489485472479 0.488926153632594 NA NA NA 0.506140539508777 99.311357293691 a5654 loss_cnaBRCA20 1066 AZD6482 PI3Kbeta 3 40 1.6094379124341 NA 2.52786527623506 1.92513681511037 0.602728461124684 1.77782587440477 1.42278806243992 0.417941404684404 0.339025587264828 0.423624907346406 0.489001428892993 NA NA NA 0.619546208420845 99.311357293691 a5655 gain_cnaBRCA64_(SDHC) 1248 FK866 NAMPT 9 35 0 NA -0.0861397149060141 -0.795880024627277 0.709740309721263 3.59073706877626 2.47190408253973 0.260864739275779 0.197658668993869 0.287122916594744 0.489034845139448 NA NA NA 0.587865456165015 99.311357293691 a5656 PIK3CA_mut 262 VX-11e ERK 17 32 1.63315443905142 NA 3.95907416912747 3.67998513782505 0.279089031302417 0.876140505401432 1.51670445982417 0.209268485973274 0.318543692001255 0.184010160644463 0.489064490591841 NA NA NA 0.418779010664245 99.311357293691 a5657 BRCA1_mut 1262 UNC1215 LMBL3 4 42 0 NA 2.95598123885544 2.73861926898766 0.217361969867778 0.0656771517232908 0.616564150114576 0.365055999280515 3.30955232016701 0.35253747696389 0.48906886327124 NA NA NA 0.0364175289525287 99.311357293691 a5658 loss_cnaBRCA7_(FAS,PTEN) 254 AC220 FLT3 4 44 0.0237165266173161 NA 2.51921286353144 2.19690271844422 0.32231014508722 0.419879027432173 0.908915562581723 0.364070873206013 0.767626206668029 0.354609557098699 0.489222031596242 NA NA NA 0.245774352719365 99.311357293691 a5659 MLL3_mut 1020 Lenalidomide TNFA 3 42 1.6094379124341 NA 4.53166952033274 4.23494493806639 0.296724582266353 0.808410417694486 0.707007431287171 0.416722176600708 0.367046955075845 0.419690895930384 0.489362302169505 NA NA NA 0.593351223559601 99.311357293691 a5660 gain_cnaBRCA9_(KRAS) 1133 JNJ-26854165 MDM2 3 40 2.30258509299405 NA 3.30854080657815 2.94333640391784 0.365204402660309 0.675497421946177 0.883588721244446 0.417573379176488 0.540645146517537 0.413319448154517 0.489381904584591 NA NA NA 0.453315739996686 99.311357293691 a5661 gain_cnaBRCA61_(NOTCH2) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 46 3.68887945411394 NA 3.92632611576572 3.42901073647713 0.497315379288592 2.11277244531949 1.14033374036006 0.415154361239597 0.235385206954168 0.436113886388704 0.489416910708846 NA NA NA 0.724111514596929 99.311357293691 a5662 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1194 SB-505124 TGFR1 (ALK5) 6 41 2.30258509299405 NA 4.14447561995344 4.4247830115804 -0.280307391626952 0.345718654671388 0.968371690068792 0.304604557935569 0.810796258285193 0.289462604598694 0.489465418299678 NA NA NA 0.190656281231812 99.311357293691 a5663 gain_cnaBRCA58_(CCND1) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 9 36 2.30258509299405 NA 2.90565234889023 3.24467063555065 -0.339018286660429 0.756575003921358 1.40110797260393 0.259681673987829 0.448096070982101 0.241964426217896 0.489678584322869 NA NA NA 0.333943999340343 99.311357293691 a5664 POLR2B_mut 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 44 2.99573227355399 NA 3.29098065295744 3.88561793078203 -0.594637277824595 1.53815162188704 1.42578794901942 0.415548604448089 0.386592107932168 0.417058706544375 0.489758951036906 NA NA NA 0.575588677183395 99.311357293691 a5665 loss_cnaBRCA17 1016 Temsirolimus MTOR 7 37 -1.6094379124341 NA -1.38815808476615 -1.81957555696513 0.431417472198978 1.84862242617982 1.43644308974976 0.287177859696757 0.233372410768868 0.30033732298725 0.48980030834508 NA NA NA 0.575907944043876 99.311357293691 a5666 gain_cnaBRCA61_(NOTCH2) 333 T0901317 LXR 3 45 2.32630161961136 NA 5.03344112356031 4.71556921152766 0.317871912032644 0.239748633515514 0.781808245034999 0.41483774021428 1.32585494804113 0.406585520236377 0.490114264193636 NA NA NA 0.131990874821078 99.311357293691 a5667 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1164 XMD8-92 MAP2K5 (ERK5) 5 21 2.30258509299405 NA 4.25287078830653 3.79677903399425 0.456091754312281 2.23831588131953 1.02498157626925 0.348731200915207 0.203765589172966 0.44497556333878 0.490162441796151 NA NA NA 0.677534057116441 99.311357293691 a5668 BRCA1_mut 1371 PLX4720 (rescreen) BRAF 4 43 2.30258509299405 NA 4.38827761146822 4.73680964445822 -0.348532032990001 0.486578127629647 0.983771070352437 0.363553752956788 0.71629202629363 0.354281644880184 0.490331426199535 NA NA NA 0.271088488937572 99.311357293691 a5669 gain_cnaBRCA62 1033 Vismodegib SMO 8 37 2.30258509299405 NA 4.9346952213365 4.72195388824304 0.212741333093457 1.11070192287021 0.703508272704801 0.271237475820283 0.191537737274915 0.302400613251531 0.490392352623029 NA NA NA 0.616930917288216 99.311357293691 a5670 gain_cnaBRCA63 308 XL-880 MET 7 42 1.63315443905142 NA 2.23885969525579 1.78254078950704 0.456318905748754 1.92449856095696 1.55629854695003 0.28377967597802 0.237110546615243 0.293207820982053 0.490405509729409 NA NA NA 0.569212715570738 99.311357293691 a5671 CDH1_mut 211 TL-2-105 CRAF 4 45 2.32630161961136 1.63315443905142 3.54428663223705 3.93984414578925 -0.395557513552194 1.35930790661321 1.07004165896317 0.362630720004082 0.290999200128061 0.369665526794044 0.490459280930196 NA NA NA 0.606860471881604 99.311357293691 a5672 PIK3CA_mut 260 NG-25 MAP3K7 (TAK1) 17 32 2.32630161961136 NA 3.03288251380524 3.30155700295006 -0.268674489144819 1.31776711100717 1.27261257035277 0.2085719657072 0.203886169946579 0.211120411195013 0.490504455331683 NA NA NA 0.496806213579366 99.311357293691 a5673 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1046 681640 WEE1, CHEK1 12 24 0.693147180559945 NA 2.8095275076275 2.54592857158767 0.263598936039828 1.26072304458889 0.965137526586241 0.246413249196878 0.209085522130504 0.273120595540612 0.490564904048856 NA NA NA 0.532320621261521 99.311357293691 a5674 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 304 SB52334 ALK5 15 34 2.99573227355399 NA 4.11120006900653 4.38602042965049 -0.274820360643965 1.32892257214186 1.25329972756783 0.215326788903503 0.206799377484445 0.219277443853982 0.490675580542038 NA NA NA 0.503411819496484 99.311357293691 a5675 loss_cnaBRCA7_(FAS,PTEN) 292 Masitinib KIT 4 44 2.99573227355399 NA 4.37349941879063 3.97731174162674 0.396187677163891 0.663845549220025 1.11583340230574 0.362784928332447 0.596807009747049 0.355059882904755 0.490749775854482 NA NA NA 0.338450710147935 99.311357293691 a5676 PIK3CA_mut 206 Ruxolitinib JAK1, JAK2, TYK2 17 32 1.65632149833295 0.0237165266173161 4.45939693966191 4.32290669343631 0.136490246225602 0.68139256237136 0.640832747083033 0.208406742652081 0.200310736810207 0.212988875563684 0.490846377365528 NA NA NA 0.5007852268894 99.311357293691 a5677 gain_cnaBRCA10_(MDM2,NUP107) 1268 XAV 939 TNKS1 (tankyrase-1) 3 44 1.6094379124341 NA 4.02673627711874 3.63653630453915 0.390199972579589 0.645736552464022 0.953041061115746 0.414438239102499 0.604271155304205 0.409426192112618 0.490913574690019 NA NA NA 0.409677709654295 99.311357293691 a5678 gain_cnaBRCA47_(EGFR) 328 SNX-2112 HSP90 7 41 0.940007258491471 NA -0.0786585666331909 0.501905558314224 -0.580564124947415 1.3645506511384 2.12801309109998 0.283941356289567 0.42546176242199 0.272819808945498 0.490984125520765 NA NA NA 0.363141447348111 99.311357293691 a5679 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1038 NU-7441 PRKDC (DNAPK) 5 38 0.693147180559945 NA 3.16960478333851 2.85645188834849 0.313152894990021 0.516419097821632 0.982604565888315 0.33058214978905 0.606392939980276 0.31869676354182 0.491037913288957 NA NA NA 0.2949643725903 99.311357293691 a5680 ARID1A_mut 1529 MLN4924 NEDD8-activating enzyme 5 32 0 NA 0.86257464632716 0.292127870165756 0.570446776161404 1.70763481629014 1.70415301629616 0.334660961752713 0.334056655860828 0.334739175828955 0.491069750779538 NA NA NA 0.516292224003028 99.311357293691 a5681 gain_cnaBRCA10_(MDM2,NUP107) 229 LY317615 PRKCB (PKCbeta) 5 44 2.99573227355399 2.32630161961136 3.83432991996131 3.3045209301925 0.529808989768817 1.40300721902953 1.6361344695843 0.327527324741923 0.377623851526073 0.323817509879508 0.491096979382135 NA NA NA 0.465500700771766 99.311357293691 a5682 loss_cnaBRCA23 1262 UNC1215 LMBL3 3 43 0 NA 2.98814460645084 2.74143024264072 0.246714363810122 0.248685367215652 0.607048156372981 0.4143282279784 0.992074308884363 0.406416461725545 0.491428477364351 NA NA NA 0.222607050027487 99.311357293691 a5683 TP53_mut 308 XL-880 MET 38 11 1.63315443905142 NA 1.76205951797177 2.14367903119628 -0.381619513224516 1.56988701425725 1.74200130542181 0.237318097289498 0.243087247527218 0.21906959084173 0.49163289550434 NA NA NA 0.523134644660052 99.311357293691 a5684 gain_cnaBRCA62 225 Genentech Cpd 10 AURKA, AURKB 10 39 2.32630161961136 NA 2.7018275778279 3.09914956715926 -0.397321989331365 2.15464098732422 1.46162957571942 0.245641932900407 0.184402873457256 0.271834940898622 0.491716435552039 NA NA NA 0.592110085998068 99.311357293691 a5685 gain_cnaBRCA8_(CHD4,WNK1) 177 GSK-650394 SGK3 3 44 2.77258872223978 NA 3.35616037161519 4.05932143211663 -0.703161060501443 2.63048179901388 1.6439829999242 0.413617611953804 0.267312650011509 0.427717963345036 0.491767882037662 NA NA NA 0.690499834494803 99.311357293691 a5686 gain_cnaBRCA9_(KRAS) 1038 NU-7441 PRKDC (DNAPK) 4 39 0.693147180559945 NA 3.20561338934541 2.8607882593988 0.344825129946601 0.19487192259836 0.982460645520175 0.364007603027377 1.76949621756081 0.350981112087222 0.492013220995957 NA NA NA 0.0740038625012753 99.311357293691 a5687 gain_cnaBRCA47_(EGFR) 1133 JNJ-26854165 MDM2 7 36 2.30258509299405 NA 3.17851002530407 2.9280418999811 0.250468125322969 0.829023399465892 0.882235828728306 0.286363542788239 0.302124313359955 0.283901556893245 0.49206749152496 NA NA NA 0.487956121919108 99.311357293691 a5688 gain_cnaBRCA63 29 AZ628 BRAF 3 11 1.38629436111989 NA 1.73465667496065 2.69102326996659 -0.956366595005937 4.61993464031686 0.939993244341145 0.46154334107623 0.207008685070996 1.01741858333915 0.492105102389323 NA NA NA 0.754865444125799 99.311357293691 a5689 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1003 Camptothecin TOP1 5 40 -2.30258509299405 NA -2.06404201487479 -2.58743637267372 0.523394357798933 1.94016074194488 1.55243427403442 0.328664321097493 0.269768553957166 0.337144294320914 0.492107073666879 NA NA NA 0.588529875113979 99.311357293691 a5690 loss_cnaBRCA38 1066 AZD6482 PI3Kbeta 3 40 1.6094379124341 NA 2.5238756599723 1.92543603633008 0.598439623642216 0.99880327591845 1.46137623286084 0.414932479742153 0.599156648832495 0.409504144234431 0.492116987411107 NA NA NA 0.413777684940174 99.311357293691 a5691 loss_cnaBRCA57 1053 MK-2206 AKT1, AKT2 5 37 1.38629436111989 0.693147180559945 0.913940801616605 1.4587355732811 -0.5447947716645 1.49782932341553 1.66521483265704 0.330330614495885 0.363722864246104 0.32716185382232 0.492138701037923 NA NA NA 0.482874613203081 99.311357293691 a5692 loss_cnaBRCA36_(FAT1,IRF2) 291 KIN001-266 MAP3K8 (COT) 9 40 2.99573227355399 NA 3.53211662782203 3.83410090971822 -0.301984281896181 0.806061533362169 1.24590898043942 0.255345259368066 0.374641723239877 0.242380692841361 0.492267702433693 NA NA NA 0.376791677090678 99.311357293691 a5693 loss_cnaBRCA22_(SYNCRIP,ZNF292) 230 GSK429286A ROCK2 19 30 2.99573227355399 2.32630161961136 5.29379666975323 5.47625129964824 -0.182454629895017 1.21769063336992 0.62437930418232 0.202926006737395 0.149836604548792 0.292217613032446 0.492271582174612 NA NA NA 0.551026041523236 99.311357293691 a5694 gain_cnaBRCA27_(CLTC,PPM1D) 1502 Bicalutamide ANDR (androgen receptor) 9 36 2.30258509299405 NA 4.67907643275926 4.52810980799637 0.150966624762884 0.541121129904969 0.594556872597253 0.258069207154404 0.27898859685889 0.253914523102566 0.492363650350308 NA NA NA 0.475969582212375 99.311357293691 a5695 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 346 THZ-2-102-1 CDK7 9 39 0.916290731874155 2.99573227355399 -1.86554707762347 -1.21276007584541 -0.652787001778064 2.6169512076241 2.5364513847923 0.255931284828916 0.249445614376097 0.257362315592545 0.492365901350366 NA NA NA 0.510678529184974 99.311357293691 a5696 gain_cnaBRCA64_(SDHC) 192 LFM-A13 BTK 8 40 2.77258872223978 NA 4.98281687720036 4.75800077367434 0.224816103526026 1.3335255817963 0.714579157663728 0.268031811422291 0.168587769589835 0.31461329527305 0.492381370983895 NA NA NA 0.655485717225675 99.311357293691 a5697 loss_cnaBRCA20 225 Genentech Cpd 10 AURKA, AURKB 3 46 2.32630161961136 NA 2.39203753405278 3.05889122381156 -0.666853689758786 0.348467022199646 1.6514319156082 0.412271461919638 1.91367804491045 0.403803319686476 0.492422607144134 NA NA NA 0.0582437848184496 99.311357293691 a5698 PIK3CA_mut 172 Embelin XIAP 17 31 3.46573590279973 NA 3.12383534217775 2.92134786494243 0.202487477235323 1.35649174011837 0.679472609426173 0.208725363207873 0.149272915747834 0.298006828275723 0.492659691444714 NA NA NA 0.570190690478509 99.311357293691 a5699 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 157 JNK-9L JNK 14 33 1.63315443905142 NA -0.108087618055826 0.125391171230432 -0.233478789286257 1.0665818233575 1.05495641963152 0.220610994160516 0.21890377669412 0.221316051489415 0.49269767019826 NA NA NA 0.497623857475987 99.311357293691 a5700 POLR2B_mut 230 GSK429286A ROCK2 3 46 2.99573227355399 2.32630161961136 5.0577580014096 5.42818264588108 -0.370424644471488 0.385702278978503 0.91528719113536 0.41198184914227 0.960390084944594 0.404708651075951 0.492725119748549 NA NA NA 0.233081856772259 99.311357293691 a5701 loss_cnaBRCA29_(MAP2K4) 173 FH535 unknown 7 41 3.46573590279973 NA 1.26304144226872 1.62591749447775 -0.362876052209028 0.876289667836177 1.33357893837855 0.28278824248902 0.414105136153297 0.272106916033208 0.492737220627636 NA NA NA 0.372868957954358 99.311357293691 a5702 gain_cnaBRCA10_(MDM2,NUP107) 1264 SGC0946 Q8TEK3 (DOT1L) 3 43 -0.693147180559945 NA 2.18564154950116 1.93432334568064 0.251318203820522 0.178419822292877 0.621570137753148 0.41303339135468 1.408577817144 0.404327989000544 0.492776199467882 NA NA NA 0.118282521713961 99.311357293691 a5703 gain_cnaBRCA15 274 PXD101, Belinostat HDAC 22 26 2.99573227355399 NA 0.508923118597213 0.809071230662421 -0.300148112065207 1.71109699623579 1.29491263373483 0.200190753784665 0.175412681294806 0.23179024147715 0.492995085632946 NA NA NA 0.503532715448867 99.311357293691 a5704 gain_cnaBRCA58_(CCND1) 1022 AZD7762 CHEK1, CHEK2 9 36 0.693147180559945 NA 0.569510469326382 0.988560739691426 -0.419050270365043 1.12155592692664 1.72167996385335 0.257579417271187 0.373632968543399 0.243396147462362 0.493180859892442 NA NA NA 0.385193336834034 99.311357293691 a5705 gain_cnaBRCA30_(CRNKL1,FOXA2) 283 GSK2126458 PI3K, MTOR 5 43 -2.05572501506252 0.0237165266173161 -3.53424818855924 -2.99967298719869 -0.53457520136055 1.32513188542895 1.66470555137663 0.326363582309477 0.403412827989953 0.32112297632364 0.493214089273063 NA NA NA 0.4409923030846 99.311357293691 a5706 TP53_mut 1192 GSK269962A ROCK1, ROCK2 37 9 1.6094379124341 NA 2.74165956426038 2.36488927505492 0.376770289205451 1.43987711269103 1.58499289170289 0.256772760736914 0.261668364532369 0.237711027713604 0.493280234503931 NA NA NA 0.528041269038875 99.311357293691 a5707 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 64 CMK RSK 3 9 1.38629436111989 NA 2.63633400260675 2.06009730037511 0.576236702231638 1.4977894783576 1.13437755065472 0.473964040315498 0.38472476309789 0.507976115975722 0.493366160773328 NA NA NA 0.587282634793903 99.311357293691 a5708 gain_cnaBRCA27_(CLTC,PPM1D) 64 CMK RSK 3 9 1.38629436111989 NA 2.63633400260675 2.06009730037511 0.576236702231638 1.4977894783576 1.13437755065472 0.473964040315498 0.38472476309789 0.507976115975722 0.493366160773328 NA NA NA 0.587282634793903 99.311357293691 a5709 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1248 FK866 NAMPT 6 38 0 NA 0.0626222404130934 -0.763336624699668 0.825958865112761 2.24635261806682 2.77896711458477 0.303546071776629 0.367688874164186 0.297217934238195 0.493379452981642 NA NA NA 0.443346467522654 99.311357293691 a5710 loss_cnaBRCA20 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 3 45 0.246860077931526 2.32630161961136 -0.904569041941495 -0.222310726658169 -0.682258315283327 1.31073631237103 1.67140214298623 0.411655186316478 0.52051530795631 0.408195189976459 0.493432379864016 NA NA NA 0.46718799980133 99.311357293691 a5711 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1001 AICAR AAPK1 (AMPK) agonist 8 37 7.60090245954208 NA 7.43198009157304 7.80475425875414 -0.372774167181098 2.04621292474304 1.21440516947813 0.269286031509066 0.182177603646947 0.306960293442501 0.493501549134288 NA NA NA 0.632596755818513 99.311357293691 a5712 PTEN_mut 1025 SB 216763 GSK3A, GSK3B 5 34 2.30258509299405 NA 4.66132114339192 4.92266724351681 -0.261346100124896 0.970798475184885 0.764097536043626 0.331212632235706 0.26920736569464 0.342032381727213 0.49356097877237 NA NA NA 0.590606607521951 99.311357293691 a5713 loss_cnaBRCA24 275 I-BET BRD2, BRD3, BRD4 3 46 2.99573227355399 NA 3.51310399118792 4.07323478116725 -0.560130789979332 0.438439189637181 1.38936894200086 0.411107672073227 1.27755639372213 0.403154823061378 0.493638857328821 NA NA NA 0.141941916960718 99.311357293691 a5714 PIK3CA_mut 222 BX-912 PDPK1 (PDK1) 17 32 2.32630161961136 NA 4.08866473550534 3.77493617843844 0.313728557066899 1.38893314400114 1.57660046545125 0.207037102489096 0.225877363803942 0.198990526732532 0.493685872911846 NA NA NA 0.477586556761799 99.311357293691 a5715 gain_cnaBRCA19 1054 PD-0332991 CDK4, CDK6 3 39 1.38629436111989 0.693147180559945 3.44760845861425 2.83946599060045 0.608142468013797 0.813150700213377 1.49618411387161 0.413817347361293 0.747884085759523 0.406462321298236 0.493755270006278 NA NA NA 0.328183086725399 99.311357293691 a5716 gain_cnaBRCA9_(KRAS) 261 TL-1-85 MAP3K7 (TAK1) 4 45 2.32630161961136 NA 4.42623780973037 3.98912367982824 0.437114129902127 1.37403555469083 1.20318240940118 0.359822145346387 0.318124322481947 0.363298304967471 0.493808106293524 NA NA NA 0.576702859039721 99.311357293691 a5717 PTEN_mut 295 NVP-BHG712 EPHB4 9 40 2.32630161961136 NA 4.1425541181956 3.82914293248277 0.313411185712838 0.82298926099692 1.29995171592161 0.254417399842885 0.380820504672431 0.241094482105932 0.493833919616734 NA NA NA 0.372437281804579 99.311357293691 a5718 gain_cnaBRCA30_(CRNKL1,FOXA2) 254 AC220 FLT3 5 43 0.0237165266173161 NA 2.48215576665512 2.19371609842781 0.288439668227311 1.13511935389284 0.857830126150991 0.325774621709807 0.254105145188583 0.336243341699265 0.493990600828677 NA NA NA 0.608093925022426 99.311357293691 a5719 loss_cnaBRCA42 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 3 45 2.77258872223978 NA 0.107378688277708 -0.472787594192859 0.580166282470567 0.708691857377222 1.43506018072212 0.41109389369175 0.818643923210418 0.404280106342737 0.494018867226938 NA NA NA 0.292064994187748 99.311357293691 a5720 PIK3CA_mut 1371 PLX4720 (rescreen) BRAF 16 31 2.30258509299405 NA 4.84136742989545 4.63787246062094 0.203494969274506 0.84075654841632 1.01262971970584 0.212246261423001 0.242037923650808 0.200956939456231 0.494051314426644 NA NA NA 0.468856630511388 99.311357293691 a5721 loss_cnaBRCA23 1495 AZD-2281 PARP1, PARP2 3 42 2.30258509299405 NA 4.43438689089071 3.96757018310279 0.466816707787922 0.579655918459382 1.15302105445882 0.412088703363624 0.805334152420343 0.404863992710892 0.494177898627371 NA NA NA 0.299072593826286 99.311357293691 a5722 gain_cnaBRCA12_(TERT) 228 KIN001-102 AKT1 9 40 2.32630161961136 NA 2.23631240388733 1.87786661420099 0.358445789686338 1.46421926291469 1.39872868290398 0.254200496089058 0.244803356139989 0.256265417351811 0.494200447465511 NA NA NA 0.516712237681007 99.311357293691 a5723 gain_cnaBRCA9_(KRAS) 223 ZSTK474 PI3K 4 45 1.63315443905142 2.32630161961136 0.433318026126943 0.954917511128584 -0.521599485001641 1.01795354950265 1.47603082606992 0.359446466094109 0.512400084715539 0.353379804668749 0.494257006267134 NA NA NA 0.397584271411619 99.311357293691 a5724 gain_cnaBRCA19 265 Tubastatin A HDAC6 4 45 2.99573227355399 NA 4.34930256918356 4.72220010879534 -0.372897539611775 1.17089304922355 1.02777633454386 0.359418809536276 0.318472758770798 0.362819737211862 0.49429006205052 NA NA NA 0.576339975434889 99.311357293691 a5725 gain_cnaBRCA64_(SDHC) 1003 Camptothecin TOP1 9 36 -2.30258509299405 NA -2.20196515969236 -2.61111051511366 0.409145355421301 1.79973081119052 1.54132522509352 0.256907498044301 0.227336973328057 0.265450372679442 0.494303173037107 NA NA NA 0.543353061180845 99.311357293691 a5726 POLR2B_mut 1072 BMS-708163 g-secretase 3 43 1.6094379124341 NA 4.05250166872343 3.65855777590166 0.393943892821767 0.620954194958012 0.970464978707667 0.41149398027573 0.634416992461747 0.40593313665617 0.494381147924632 NA NA NA 0.391020972504998 99.311357293691 a5727 loss_cnaBRCA36_(FAT1,IRF2) 1243 piperlongumine Increases ROS levels 9 38 2.30258509299405 NA 1.53356631424704 1.75209263914908 -0.218526324902035 0.670549471201468 0.890655573574341 0.255385120815865 0.325891428279686 0.245354468534963 0.494419470642235 NA NA NA 0.424058253563324 99.311357293691 a5728 loss_cnaBRCA29_(MAP2K4) 299 OSI-027 MTORC1/2 7 41 2.99573227355399 NA 0.790457765898823 1.35066669982852 -0.560208933929701 1.28276459593932 2.07510674435303 0.28154987310422 0.436719984089897 0.269966321228628 0.494623783810917 NA NA NA 0.355407025978202 99.311357293691 a5729 gain_cnaBRCA63 279 BIX02189 MAP2K5 (MEK5) 7 42 2.99573227355399 NA 5.24461725633546 4.99114584258021 0.253471413755249 1.29742108168128 0.828641196855138 0.280962989302286 0.195365573547475 0.305888018502127 0.49469975029625 NA NA NA 0.632647071967781 99.311357293691 a5730 BRCA2_mut 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 38 1.6094379124341 NA 2.1016418019895 2.62861766027551 -0.526975858286014 0.898548574568612 1.66644198222095 0.327771701379933 0.586474535935925 0.316228145899017 0.494709245438947 NA NA NA 0.30729186998012 99.311357293691 a5731 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 186 Bexarotene Retinioic acid X family agonist 9 38 2.07944154167984 NA 3.8401637137397 3.54856798160808 0.291595732131628 1.11735375522852 1.14843434658198 0.255120920593811 0.260969930755718 0.25390718502933 0.494863833777728 NA NA NA 0.496795445416181 99.311357293691 a5732 loss_cnaBRCA38 1527 GDC0941 (rescreen) PI3K 3 42 1.38629436111989 NA 1.42570752760918 0.948866435203217 0.476841092405964 1.7505041793761 1.12234395194045 0.411377080283296 0.272402144492975 0.424861818501844 0.494919810861024 NA NA NA 0.68534340870557 99.311357293691 a5733 loss_cnaBRCA38 185 OSI-906 IGF1R 4 44 0.940007258491471 NA 3.26582665964697 2.85964111741028 0.406185542236686 0.323303485380313 1.16631492413208 0.359246304742338 1.25635992373814 0.348264035581087 0.49496741354761 NA NA NA 0.112749695039305 99.311357293691 a5734 loss_cnaBRCA7_(FAS,PTEN) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 4 43 0.940007258491471 NA 2.30206484457824 1.85020231640371 0.451862528174525 1.50004566690584 1.23722161560939 0.359632938623727 0.301232514545098 0.365223596543745 0.494997675018697 NA NA NA 0.595671062948342 99.311357293691 a5735 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 211 TL-2-105 CRAF 6 43 2.32630161961136 1.63315443905142 3.62062463864491 3.94759035482779 -0.32696571618288 1.18954055046433 1.07857400672746 0.2997167818453 0.274867230087492 0.303146297002779 0.494998147099442 NA NA NA 0.546473158136246 99.311357293691 a5736 loss_cnaBRCA7_(FAS,PTEN) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 4 41 0.693147180559945 NA 1.09807534537188 0.579470734744371 0.51860461062751 0.83844043398637 1.47471019541903 0.360273526023971 0.618534829196872 0.351665440598756 0.49528635066435 NA NA NA 0.327295527814193 99.311357293691 a5737 gain_cnaBRCA9_(KRAS) 155 AP-24534 ABL 4 43 -0.669430653942629 NA 1.81930997948198 1.41057369407045 0.408736285411532 0.853402933311963 1.1552127337763 0.359301452603463 0.478948770219563 0.353819061598642 0.495393305437394 NA NA NA 0.424799684655845 99.311357293691 a5738 gain_cnaBRCA63 1502 Bicalutamide ANDR (androgen receptor) 5 40 2.30258509299405 NA 4.72789189827141 4.53710453728364 0.190787360987775 1.31998025823945 0.445716029453809 0.326114901479234 0.144538041229678 0.428046891698219 0.495452861367919 NA NA NA 0.763913445026905 99.311357293691 a5739 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1026 17-AAG HSP90 4 39 0 NA -0.309532195973156 -0.956378389123563 0.646846193150407 2.15877418204429 1.75903750082792 0.361101553442548 0.299635876012684 0.367727346828 0.495456385720597 NA NA NA 0.598022397212226 99.311357293691 a5740 gain_cnaBRCA47_(EGFR) 1039 SL 0101-1 RSK, AURKB, PIM3 6 37 2.30258509299405 NA 4.90059850952527 4.60800076720402 0.292597742321246 0.526993257969634 1.01303310487232 0.302604848696022 0.555221035366843 0.288833347018925 0.495593856582386 NA NA NA 0.30301851999894 99.311357293691 a5741 ASH1L_mut 1003 Camptothecin TOP1 3 42 -2.30258509299405 NA -3.13935039983377 -2.48570509004337 -0.653645309790402 1.79886757376597 1.58189676886766 0.410415200977764 0.363364885399529 0.413203517861844 0.495923609634531 NA NA NA 0.596837301560306 99.311357293691 a5742 ASH1L_mut 268 YM155 BIRC5 (Survivin) 3 46 1.63315443905142 NA -2.98085997386209 -3.6356683081582 0.654808334296108 1.52195419094173 1.60561684772857 0.408707098307574 0.430241815550925 0.40782353225955 0.496152876922133 NA NA NA 0.537880949121064 99.311357293691 a5743 gain_cnaBRCA13_(FGFR1,WHSC1L1) 329 QL-XI-92 DDR1 11 37 2.32630161961136 NA 4.42565024554798 4.20210627060053 0.223543974947443 0.869809198929497 0.96985293783983 0.235556935135241 0.25700346147473 0.230492651231584 0.496207275863715 NA NA NA 0.475736495891575 99.311357293691 a5744 CDH1_mut 309 Y-39983 ROCK 4 45 2.99573227355399 NA 4.57812721258551 4.96670125744471 -0.388574044859201 1.33722160877637 1.06670806240394 0.357806277111702 0.290583133198669 0.364274030125457 0.496219508072727 NA NA NA 0.607500463580185 99.311357293691 a5745 loss_cnaBRCA36_(FAT1,IRF2) 1069 EHT 1864 Rac GTPases 9 37 2.30258509299405 NA 3.73800507722679 3.51846897759034 0.219536099636458 0.879516049291088 0.856807770247552 0.254983646213763 0.249610112076305 0.256225617063474 0.496281164112649 NA NA NA 0.512516088599265 99.311357293691 a5746 gain_cnaBRCA13_(FGFR1,WHSC1L1) 258 STF-62247 stimulates autophagy 11 38 2.32630161961136 NA 4.80626359770671 4.58006323128815 0.226200366418555 1.20843312454116 0.885961520451328 0.234732280543301 0.187184844427731 0.255316242519566 0.496341127795535 NA NA NA 0.57326160763561 99.311357293691 a5747 loss_cnaBRCA28_(GPS2) 1149 TW 37 BCL2, BCL2L1 4 39 1.6094379124341 NA 0.266172488639522 -0.184287496764067 0.450459985403588 1.02955123740353 1.26628887149086 0.360227572675298 0.437530420088292 0.355732404781573 0.496494505296841 NA NA NA 0.46128351329611 99.311357293691 a5748 gain_cnaBRCA48 1013 Nilotinib ABL 4 36 0.693147180559945 NA 2.89044925669945 3.23762495192846 -0.347175695229013 0.98548851428373 0.95837756833648 0.36143588532806 0.352287916294333 0.362253569677793 0.497016987539039 NA NA NA 0.542602971218695 99.311357293691 a5749 gain_cnaBRCA16 271 VNLG/124 HDAC, RAR 16 33 1.63315443905142 NA 4.26591019451209 4.09593945647606 0.169970738036034 0.96658190561328 0.73353715174617 0.208506005871516 0.17584721692901 0.231713877928913 0.497056601066886 NA NA NA 0.539949960426656 99.311357293691 a5750 BRCA2_mut 1527 GDC0941 (rescreen) PI3K 5 40 1.38629436111989 NA 0.645895494876857 1.02250088467446 -0.376605389797603 0.54737026327072 1.20450288491715 0.324884725406603 0.688026761898353 0.312664580976498 0.497071797506157 NA NA NA 0.25272133136678 99.311357293691 a5751 PIK3CA_mut 55 A-770041 SRC family 4 8 1.63315443905142 NA 3.05151168961645 2.53165246011114 0.519859229505307 1.39126033522617 1.11577494207473 0.431399997904359 0.373660641608673 0.465917641543958 0.497216138596268 NA NA NA 0.544234416659046 99.311357293691 a5752 loss_cnaBRCA34 255 CP724714 ERBB2 5 43 2.32630161961136 NA 4.28745710145527 3.74670761356427 0.540749487890998 0.449292331927476 1.74509505724289 0.323269531582588 1.20355823917842 0.309868213566165 0.497300957694482 NA NA NA 0.11824222722027 99.311357293691 a5753 gain_cnaBRCA64_(SDHC) 1053 MK-2206 AKT1, AKT2 7 35 1.38629436111989 0.693147180559945 1.78368058919838 1.31591874557415 0.467761843624228 1.18541332115296 1.71840895401289 0.283582107645399 0.394598099479152 0.272206358406067 0.497346941275287 NA NA NA 0.398590354275202 99.311357293691 a5754 gain_cnaBRCA16 1170 CCT018159 HSP90 15 28 2.30258509299405 NA 3.51324463590634 3.25153400365864 0.261710632247699 1.23332594934596 1.17397498683017 0.219083041139956 0.212199080370023 0.222926923642844 0.497387000854913 NA NA NA 0.505729903710451 99.311357293691 a5755 loss_cnaBRCA28_(GPS2) 133 Doxorubicin DNA intercalating 4 44 0.0237165266173161 NA -1.63293668564635 -0.975891192432815 -0.657045493213538 1.16106576558489 1.87794271959688 0.357143399012899 0.56589860168907 0.349875151332934 0.497483285492401 NA NA NA 0.359727061257617 99.311357293691 a5756 gain_cnaBRCA8_(CHD4,WNK1) 235 QL-XII-47 BTK, BMX 4 45 2.32630161961136 NA 1.21405675438686 1.75198783619251 -0.537931081805652 1.84601900418045 1.48199771286832 0.356751089483397 0.291400619705141 0.362976998638221 0.497484314659325 NA NA NA 0.606606614349344 99.311357293691 a5757 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1495 AZD-2281 PARP1, PARP2 18 27 2.30258509299405 NA 4.14019674460278 3.90435433185702 0.235842412745757 1.15504966012188 1.11818607579413 0.208175212939026 0.204183786107405 0.210915175793316 0.497561514777285 NA NA NA 0.501129246824624 99.311357293691 a5758 loss_cnaBRCA60 276 CAY10603 HDAC6 3 46 2.99573227355399 NA 0.795334937419996 1.20033571113026 -0.405000773710262 0.247927035416481 1.0147321512457 0.407353771784518 1.6335482454744 0.399120864765226 0.497573260489163 NA NA NA 0.0848200861909258 99.311357293691 a5759 gain_cnaBRCA13_(FGFR1,WHSC1L1) 235 QL-XII-47 BTK, BMX 11 38 2.32630161961136 NA 1.43439138329156 1.78729932710535 -0.352907943813795 1.3175917675813 1.55529948553825 0.234044789410832 0.267843160906832 0.226906745032236 0.497597070296266 NA NA NA 0.462574307749368 99.311357293691 a5760 gain_cnaBRCA64_(SDHC) 193 GW-2580 CSF1R (cFMS) 8 40 2.99573227355399 NA 5.62833112606275 5.43040041582091 0.197930710241836 0.853032561525281 0.727108334439534 0.264740611120005 0.232031834620617 0.272216258385215 0.497683659573389 NA NA NA 0.554656801881537 99.311357293691 a5761 gain_cnaBRCA19 155 AP-24534 ABL 4 43 -0.669430653942629 NA 1.81723188072939 1.41076700558232 0.406464875147075 0.505650020611029 1.16980168725809 0.357283972813259 0.803846254482302 0.347464770802129 0.497804938376055 NA NA NA 0.232707593971917 99.311357293691 a5762 loss_cnaBRCA42 258 STF-62247 stimulates autophagy 3 46 2.32630161961136 NA 4.99907102730854 4.60682802786517 0.392242999443367 0.291285124327245 0.982953814489237 0.407022957590425 1.3465946822698 0.399045197914191 0.497920806052423 NA NA NA 0.128282323225338 99.311357293691 a5763 loss_cnaBRCA60 255 CP724714 ERBB2 3 45 2.32630161961136 NA 4.44174170182618 3.76045528411248 0.681286417713704 0.188559336516679 1.70990202392894 0.40727812670626 3.6131142074391 0.398435938538908 0.498016104998445 NA NA NA 0.0189878365424054 99.311357293691 a5764 gain_cnaBRCA27_(CLTC,PPM1D) 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 3 11 1.38629436111989 NA 1.63064768353347 1.99965711489773 -0.369009431364261 1.07401879085669 0.747488674322133 0.454954340441413 0.343578189232537 0.493665581888449 0.49818380689873 NA NA NA 0.621187799524274 99.311357293691 a5765 gain_cnaBRCA9_(KRAS) 1114 Cetuximab EGFR 4 41 4.18661983833127 NA 5.99589606293735 6.31055471290827 -0.314658649970927 0.410989334230052 0.905536713148252 0.357526890172169 0.765612690559011 0.347483040060256 0.498561937835568 NA NA NA 0.251153445850868 99.311357293691 a5766 loss_cnaBRCA24 272 AR-42 HDAC 3 46 1.63315443905142 NA -0.443216943925071 0.18013289623667 -0.623349840161741 1.031289325316 1.55239860919561 0.406399652694157 0.604437401667798 0.401539808441812 0.498575997573484 NA NA NA 0.409524812314426 99.311357293691 a5767 BRCA2_mut 1373 Dabrafenib BRAF 5 41 2.30258509299405 NA 3.74236962968767 4.27217687566272 -0.529807245975053 1.26283280570079 1.67242068897221 0.323167604460256 0.419538709782761 0.316790655287006 0.49867440393972 NA NA NA 0.427888152480731 99.311357293691 a5768 MACF1_mut 1241 CHIR-99021 GSK3B 3 43 2.30258509299405 NA 3.85829541262541 4.25752372131449 -0.399228308689086 0.689325158324776 0.991974733628063 0.407273093781383 0.579158186623139 0.402458142486092 0.498796525994453 NA NA NA 0.426627287794777 99.311357293691 a5769 NF1_mut 1143 HG-5-88-01 EGFR, ADCK4 3 23 2.30258509299405 NA 4.90034892786572 4.48630245423749 0.414046473628233 0.939553857130256 0.986839255380435 0.421213125662161 0.440684129479158 0.419568304940012 0.499173954963411 NA NA NA 0.533862265051938 99.311357293691 a5770 gain_cnaBRCA64_(SDHC) 1527 GDC0941 (rescreen) PI3K 8 37 1.38629436111989 NA 1.23393284526388 0.925893245925719 0.308039599338162 1.17327403432888 1.1565144217009 0.26572106405563 0.262547018279802 0.266351714737049 0.499209644382668 NA NA NA 0.514699922438332 99.311357293691 a5771 loss_cnaBRCA36_(FAT1,IRF2) 192 LFM-A13 BTK 9 39 2.77258872223978 NA 4.96712904228004 4.75585652779631 0.211272514483735 0.729972617231409 0.86007973820738 0.25184374398388 0.28942525992966 0.24564293878621 0.499268735195836 NA NA NA 0.462708391132564 99.311357293691 a5772 loss_cnaBRCA34 155 AP-24534 ABL 5 42 -0.669430653942629 NA 1.11777323773629 1.48435815653038 -0.366584918794085 0.860129525373469 1.16122555662661 0.322217822824462 0.426197343516272 0.315687952871985 0.499298902632531 NA NA NA 0.421395856693106 99.311357293691 a5773 loss_cnaBRCA18 329 QL-XI-92 DDR1 15 33 2.32630161961136 NA 4.11497821503768 4.31622459053583 -0.201246375498148 0.758629643133323 1.02128301829254 0.21204557640066 0.265276182284351 0.197052503462368 0.499320745444164 NA NA NA 0.45175708023527 99.311357293691 a5774 NF1_mut 1006 Cytarabine DNA synthesis 4 41 0.693147180559945 NA 0.710447479513412 1.25712701091891 -0.546679531405496 1.35180300224277 1.54528594628138 0.356705384184846 0.404407691430262 0.353772408738359 0.49954396242664 NA NA NA 0.490654912749677 99.311357293691 a5775 loss_cnaBRCA17 223 ZSTK474 PI3K 11 38 1.63315443905142 2.32630161961136 0.650128955495129 0.988240568285464 -0.338111612790335 0.863225361437857 1.57293551711086 0.232972165761709 0.391684058294058 0.214955800229734 0.499560074865914 NA NA NA 0.36081323041354 99.311357293691 a5776 loss_cnaBRCA20 1058 GDC0941 PI3K (class 1) 3 40 1.38629436111989 0.693147180559945 1.87336326231749 1.30645051758754 0.566912744729956 1.12335266251594 1.40282192149629 0.407706279666853 0.504661415463472 0.404123100760552 0.499644175643766 NA NA NA 0.4798550581556 99.311357293691 a5777 gain_cnaBRCA10_(MDM2,NUP107) 158 PF-562271 FAK 3 42 0.940007258491471 NA 1.84248609366542 2.36830478497432 -0.525818691308899 1.45660359918262 1.28385701167966 0.406853242690991 0.360989559276089 0.409561724183734 0.499650575548282 NA NA NA 0.599086001430666 99.311357293691 a5778 gain_cnaBRCA19 1001 AICAR AAPK1 (AMPK) agonist 4 41 7.60090245954208 NA 7.28867655346918 7.78236688030758 -0.493690326838397 0.784647636126099 1.41932874470259 0.356578111611732 0.629187298996791 0.347833670445283 0.499696198558798 NA NA NA 0.321547153346446 99.311357293691 a5779 loss_cnaBRCA23 346 THZ-2-102-1 CDK7 3 45 0.916290731874155 2.99573227355399 -2.30533380054489 -1.27047922788773 -1.03485457265716 1.67369511713719 2.58388942386115 0.405653916526597 0.618305306660184 0.40050265429345 0.499722938377755 NA NA NA 0.400895885231925 99.311357293691 a5780 gain_cnaBRCA8_(CHD4,WNK1) 225 Genentech Cpd 10 AURKA, AURKB 4 45 2.32630161961136 NA 2.49089004533951 3.06492330480294 -0.574033259463428 2.32131750368325 1.55829516556503 0.354826230449831 0.247287696987855 0.368372611395022 0.499796114952294 NA NA NA 0.658579872791793 99.311357293691 a5781 gain_cnaBRCA9_(KRAS) 1243 piperlongumine Increases ROS levels 4 43 2.30258509299405 NA 1.98848130380075 1.68436492792291 0.304116375877831 0.312973689183274 0.881869627542777 0.355362976951168 0.971699495479775 0.344854121720026 0.50010722745167 NA NA NA 0.175638870027571 99.311357293691 a5782 BRCA1_mut 1043 JNK Inhibitor VIII JNK 4 39 2.30258509299405 NA 4.55499003354429 4.82218668349771 -0.267196649953419 0.358947398043747 0.770511227392587 0.357160340496991 0.744389432573221 0.34677839913847 0.500147280166304 NA NA NA 0.263139011409774 99.311357293691 a5783 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 91 KIN001-135 IKKE 5 9 1.6094379124341 NA 3.80527042707703 3.64686498971531 0.15840543736172 0.260964602417336 0.465318005784086 0.387569284179325 0.606999707601713 0.340424044186295 0.500382103151327 NA NA NA 0.430421129249763 99.311357293691 a5784 MACF1_mut 1010 Gefitinib EGFR 3 42 -0.693147180559945 NA 1.79579619771546 1.3716193587475 0.424176838967963 1.44976028867634 1.02066269907162 0.406090854062199 0.292584120479148 0.41558963539452 0.500450277331111 NA NA NA 0.664889160385416 99.311357293691 a5785 gain_cnaBRCA31 1066 AZD6482 PI3Kbeta 13 30 1.6094379124341 NA 2.19429911019523 1.86877266668607 0.325526443509163 1.6415991594962 1.35168571472841 0.225655428648396 0.198298373647479 0.240829979900003 0.500586260995509 NA NA NA 0.536959212476988 99.311357293691 a5786 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1495 AZD-2281 PARP1, PARP2 6 39 2.30258509299405 NA 4.29102809837394 3.95371640442938 0.337311693944564 0.486744777014152 1.19223008011125 0.297716464906773 0.692994994242654 0.282924998766253 0.500840425479143 NA NA NA 0.237979738508591 99.311357293691 a5787 NF1_mut 200 LAQ824 HDAC 5 43 0.0237165266173161 NA -3.09067678577736 -2.63723376152541 -0.453443024251951 0.938257482662266 1.4516354574123 0.320588002972753 0.483282076222111 0.31236700780254 0.500857951411765 NA NA NA 0.37341958094029 99.311357293691 a5788 POLR2B_mut 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 3 44 2.32630161961136 NA 0.834530423836019 1.45664576600309 -0.622115342167071 1.30416393273112 1.54670650594076 0.40482799671716 0.477022348612468 0.402219386662939 0.500969759477712 NA NA NA 0.500414176585764 99.311357293691 a5789 MACF1_mut 1114 Cetuximab EGFR 3 42 4.18661983833127 NA 6.61568499733858 6.2587922021184 0.356892795220179 0.500634699246952 0.894557116546794 0.405489373065021 0.712880660803201 0.398960321950007 0.501081691793524 NA NA NA 0.346207498586142 99.311357293691 a5790 gain_cnaBRCA9_(KRAS) 1052 RO-3306 CDK1 4 39 1.6094379124341 NA 3.91500786952909 3.48574161615228 0.429266253376816 0.630641432875132 1.23874351092121 0.35632570183598 0.680681970767074 0.346533604085308 0.501143806607799 NA NA NA 0.294663162502006 99.311357293691 a5791 gain_cnaBRCA63 3 Rapamycin MTOR 3 11 -2.30258509299405 NA -1.79247813551398 -3.00125958878892 1.20878145327494 1.36449695767115 2.8673015438716 0.451695828181913 0.885880651092118 0.421574583202982 0.501206559834065 NA NA NA 0.333414844917008 99.311357293691 a5792 loss_cnaBRCA17 1161 ZG-10 IRAK1 4 22 2.30258509299405 NA 2.41783071241807 1.89497057582603 0.522860136592034 1.98003701293473 1.30687192559226 0.371159615810655 0.26406583976785 0.400085215967187 0.501250217327153 NA NA NA 0.641601597757244 99.311357293691 a5793 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1378 Bleomycin (50 uM) DNA damage 8 40 3.91202300542815 NA 4.22636189466451 3.72998875687187 0.496373137792645 1.27514704856074 1.98126053205562 0.262506917883621 0.389267369871501 0.250534005882428 0.501300061746096 NA NA NA 0.380416191831222 99.311357293691 a5794 gain_cnaBRCA8_(CHD4,WNK1) 1039 SL 0101-1 RSK, AURKB, PIM3 3 40 2.30258509299405 NA 4.28350779136286 4.67622740174029 -0.392719610377434 1.45694936187308 0.935062095461375 0.406089543356845 0.269549251782194 0.419993080976788 0.501336890232339 NA NA NA 0.688423221580847 99.311357293691 a5795 TP53_mut 1009 ATRA Retinoic acid and retinoid X receptor agonist 35 10 2.30258509299405 NA 4.16866114155314 3.88655492670018 0.282106214852955 1.14752756391309 1.20857751106707 0.24307531329142 0.245838290708214 0.233420043207555 0.501463862217033 NA NA NA 0.521084023878521 99.311357293691 a5796 loss_cnaBRCA29_(MAP2K4) 1042 BIRB 0796 p38, JNK2 5 38 2.30258509299405 NA 4.63071106186005 4.33184351418086 0.298867547679188 0.571583154361594 0.95701670524921 0.322577260819155 0.522876759748099 0.312290836763776 0.501534689142571 NA NA NA 0.34924603812933 99.311357293691 a5797 BRCA2_mut 1033 Vismodegib SMO 5 40 2.30258509299405 NA 4.53564812004856 4.78779037588605 -0.252142255837481 0.934225270581115 0.767562041507156 0.32138024104137 0.269894493092272 0.32849755746439 0.501699721441256 NA NA NA 0.588882046959967 99.311357293691 a5798 loss_cnaBRCA60 310 YM201636 FYV1 3 46 1.63315443905142 NA 2.80054608610317 2.38950148799702 0.411044598106152 0.909964092519036 1.02420439143671 0.403141459193561 0.45171518468192 0.401330634337115 0.502008559233317 NA NA NA 0.520337121696081 99.311357293691 a5799 gain_cnaBRCA15 194 AUY922 HSP90 22 25 -1.36257783450257 NA -2.21154450188291 -2.55408533899129 0.342540837108383 1.93050436396568 1.53779782583252 0.19775174775393 0.17743592995808 0.222747640394758 0.502200586654096 NA NA NA 0.508800362940192 99.311357293691 a5800 TP53_mut 3 Rapamycin MTOR 9 5 -2.30258509299405 NA -2.37340345247437 -3.40613176219015 1.03272830971578 2.64432919362971 2.73925586272141 0.385872560863245 0.390544532883299 0.377010531863856 0.502223635603229 NA NA NA 0.512831172015455 99.311357293691 a5801 loss_cnaBRCA33 269 NSC-207895 MDM4 6 43 2.99573227355399 NA 4.29599206919076 4.64691221302581 -0.350920143835052 1.08661449249928 1.20280442950454 0.294647553552355 0.32294815342276 0.291751622480808 0.502287075819108 NA NA NA 0.489066519837275 99.311357293691 a5802 loss_cnaBRCA60 306 TG101348 JAK2 3 45 2.32630161961136 NA 2.73861334012394 3.257307304426 -0.518693964302056 1.67005949440394 1.26630986422529 0.403181710890617 0.310584123523804 0.409610616607954 0.50232704922984 NA NA NA 0.646885025279658 99.311357293691 a5803 gain_cnaBRCA62 32 VX-680 AURKA, AURKB, AURKC, FLT3, ABL1, JAK2 4 8 0.693147180559945 NA 0.571005372722876 1.50120917618823 -0.930203803465351 1.87034246205785 2.30399572722078 0.426119631907955 0.49734410800998 0.403735038427098 0.502373548353357 NA NA NA 0.47626447928773 99.311357293691 a5804 loss_cnaBRCA34 211 TL-2-105 CRAF 5 44 2.32630161961136 1.63315443905142 3.59503763657609 3.94306692969509 -0.348029293118998 0.935790745594321 1.10443932639376 0.318970570022593 0.371909312800443 0.315118526479304 0.502434699899043 NA NA NA 0.472414420651757 99.311357293691 a5805 gain_cnaBRCA63 258 STF-62247 stimulates autophagy 7 42 2.32630161961136 NA 4.85877377243871 4.59285442753935 0.26591934489936 1.2342924722793 0.917536093388956 0.275910823427084 0.21544273409389 0.289818947521918 0.50245384642602 NA NA NA 0.602048064798393 99.311357293691 a5806 loss_cnaBRCA60 304 SB52334 ALK5 3 46 2.99573227355399 NA 3.81935910953909 4.33336126770864 -0.514002158169555 0.519861696066519 1.30009476743619 0.402619633704073 0.988728660062283 0.395357454736302 0.502559507976333 NA NA NA 0.223545134332072 99.311357293691 a5807 loss_cnaBRCA42 255 CP724714 ERBB2 3 45 2.32630161961136 NA 4.43503708829234 3.76090225834807 0.674134829944272 0.187637453766099 1.71008780561902 0.402960181905719 3.59275196083517 0.394210652651398 0.50256075936676 NA NA NA 0.0200765063889776 99.311357293691 a5808 loss_cnaBRCA17 192 LFM-A13 BTK 11 37 2.77258872223978 NA 4.64540074473633 4.84008534520208 -0.194684600465751 0.977028830915206 0.796381780892568 0.23205240571856 0.199261878775251 0.244461394191556 0.502605535680372 NA NA NA 0.555432262002794 99.311357293691 a5809 gain_cnaBRCA14_(RAD21) 223 ZSTK474 PI3K 21 28 1.63315443905142 2.32630161961136 0.75061376644203 1.03363110750041 -0.283017341058378 1.35921501384857 1.51607396977933 0.194996234413098 0.208221170436474 0.186677791915108 0.502676604227336 NA NA NA 0.49601756174859 99.311357293691 a5810 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 226 GSK1070916 AURKB 6 43 0.940007258491471 2.32630161961136 2.90830989292609 2.33357159055109 0.574738302375004 0.603842898060572 2.05530666300129 0.294305122176676 0.951801046631422 0.27963627653293 0.502781554840278 NA NA NA 0.161384099217223 99.311357293691 a5811 loss_cnaBRCA29_(MAP2K4) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 7 39 1.38629436111989 NA 2.50941530395295 2.92128507935651 -0.411869775403562 2.53041176679068 1.24246000785803 0.277283574176729 0.162767886558612 0.331495398482575 0.502891822445112 NA NA NA 0.686836941213396 99.311357293691 a5812 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 282 EKB-569 EGFR 7 40 0.916290731874155 2.99573227355399 1.07879902011905 1.66543942765051 -0.586640407531465 2.71408523980517 2.01498054172323 0.276515399755375 0.216146640837845 0.291139490126175 0.503182575624653 NA NA NA 0.601470186488559 99.311357293691 a5813 gain_cnaBRCA12_(TERT) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 9 34 1.6094379124341 NA 2.24541011260069 2.65255850255914 -0.407148389958446 1.36717183258746 1.66126780857836 0.253184061743809 0.297803377932305 0.245082934765867 0.503211548539655 NA NA NA 0.460514864011853 99.311357293691 a5814 POLR2B_mut 1377 Afatinib (rescreen) ERBB2, EGFR 3 44 2.30258509299405 NA 2.08313242092799 2.88587929198507 -0.802746871057078 3.10545863014979 1.92617919292747 0.402690038854453 0.25849543228929 0.416756070257948 0.503222174978295 NA NA NA 0.699774293397187 99.311357293691 a5815 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1050 ZM-447439 AURKB 7 32 1.38629436111989 0.693147180559945 3.19373978300553 2.82102689686766 0.372712886137863 1.26095230366122 1.33269040535627 0.282075783546478 0.295580479178854 0.279669520122512 0.503233863413372 NA NA NA 0.500642224532624 99.311357293691 a5816 gain_cnaBRCA48 1018 ABT-888 PARP1, PARP2 5 40 1.6094379124341 NA 4.21344616681932 4.42677994517226 -0.213333778352937 0.737860370144003 0.658464352393686 0.32020113820676 0.289124862894184 0.323986830232213 0.503262104726425 NA NA NA 0.565422579340601 99.311357293691 a5817 gain_cnaBRCA48 193 GW-2580 CSF1R (cFMS) 5 43 2.99573227355399 NA 5.67690045515942 5.43856193873352 0.238338516425896 0.423951218990279 0.771520220318542 0.318745988822528 0.56218382151028 0.308920635064486 0.503309393259267 NA NA NA 0.318348435824159 99.311357293691 a5818 loss_cnaBRCA20 306 TG101348 JAK2 3 45 2.32630161961136 NA 2.73978729210748 3.25722904096043 -0.517441748852954 0.843443481528804 1.30309807692411 0.402198723041155 0.613487163259656 0.397085804987408 0.503364541014068 NA NA NA 0.404087243419338 99.311357293691 a5819 BRCA1_mut 1373 Dabrafenib BRAF 4 42 2.30258509299405 NA 4.74280629040522 4.16428273545212 0.578523554953098 0.468365170301883 1.69381305814146 0.352840553640027 1.23519764413783 0.341551006572049 0.503647080874777 NA NA NA 0.12216188555351 99.311357293691 a5820 loss_cnaBRCA20 1031 Elesclomol HSP70 3 41 -1.6094379124341 NA -2.30448742009226 -3.02682967914234 0.722342259050079 1.28780162610385 1.81190228653474 0.403446844543825 0.560911125136154 0.398665129139804 0.503659607683206 NA NA NA 0.439548952137014 99.311357293691 a5821 ARID1A_mut 1377 Afatinib (rescreen) ERBB2, EGFR 5 42 2.30258509299405 NA 2.26660407717093 2.90226346962553 -0.635659392454601 2.15929789168283 1.97656422385792 0.318868311221005 0.294382444822935 0.321598147321467 0.503747068096721 NA NA NA 0.558659205497507 99.311357293691 a5822 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 9 38 2.77258872223978 NA 5.21847415120001 4.96173953516537 0.256734616034644 0.434365503044495 1.11505474361939 0.249852335087878 0.591056642931299 0.230243956634184 0.503771056748241 NA NA NA 0.275530501649416 99.311357293691 a5823 BRCA2_mut 197 Bryostatin 1 PRKC 6 42 -4.8283137373023 NA -3.05614103376245 -2.77118433585172 -0.28495669791073 0.944851747786351 0.971882522216406 0.294078749609892 0.301588792716256 0.293200763875122 0.503798317496502 NA NA NA 0.514555524694397 99.311357293691 a5824 PIK3CA_mut 1039 SL 0101-1 RSK, AURKB, PIM3 15 28 2.30258509299405 NA 4.51293533596177 4.72162819300978 -0.208692857048002 1.18638644461759 0.830986353212326 0.215783607614824 0.175906306073203 0.251138729584742 0.503850618652935 NA NA NA 0.55067774773294 99.311357293691 a5825 loss_cnaBRCA18 1129 PF-4708671 RPS6KB1 (p70S6KA) 14 29 2.30258509299405 NA 3.97889865600272 3.72693091447793 0.251967741524794 0.839914753427332 1.26620976836037 0.219425392640306 0.299992041450184 0.198993680052768 0.503941645482478 NA NA NA 0.443249462878306 99.311357293691 a5826 loss_cnaBRCA57 309 Y-39983 ROCK 5 44 2.99573227355399 NA 5.24490467955489 4.8997623190359 0.345142360518991 0.78560882338288 1.11001451137582 0.317756770229057 0.439331064323828 0.310934998580513 0.504054484492907 NA NA NA 0.409310438266748 99.311357293691 a5827 loss_cnaBRCA42 309 Y-39983 ROCK 3 46 2.99573227355399 NA 4.52613454758347 4.96164482157834 -0.435510273994868 0.794649151930447 1.09735180512937 0.400951953448692 0.548053531469681 0.396873884891933 0.504322472331139 NA NA NA 0.447655454201588 99.311357293691 a5828 POLR2B_mut 1494 SN-38 TOP1 3 45 -2.99573227355399 NA -3.93857871723088 -3.26146916276977 -0.67710955446111 2.04047606535992 1.67021583893183 0.401130360702422 0.33183900853141 0.40540242684691 0.504493465382242 NA NA NA 0.626302873028845 99.311357293691 a5829 loss_cnaBRCA22_(SYNCRIP,ZNF292) 333 T0901317 LXR 18 30 2.32630161961136 NA 4.83152121942095 4.67778519799496 0.153736021425987 0.847941485685574 0.714481503099225 0.200564809429274 0.181304988635729 0.21517145056817 0.504494249757695 NA NA NA 0.524178683750268 99.311357293691 a5830 loss_cnaBRCA60 1219 PFI-1 BRD2, BRD3, BRD4 3 44 2.30258509299405 NA 2.79638800634435 3.19812377080693 -0.401735764462579 0.232811424097807 1.02241552709206 0.401478261934384 1.72558441244621 0.392928074562003 0.504501276727436 NA NA NA 0.0781000782543923 99.311357293691 a5831 ARID1A_mut 262 VX-11e ERK 5 44 1.63315443905142 NA 3.39662923321227 3.82001452544334 -0.423385292231077 0.633674325883279 1.38133634385664 0.317351984899845 0.668143358405629 0.306504128494151 0.504595291797365 NA NA NA 0.258569864588962 99.311357293691 a5832 loss_cnaBRCA42 152 CP466722 ATM 3 46 2.77258872223978 NA 2.32987238315997 2.75624628529793 -0.426373902137954 1.42314751084393 1.04529596323853 0.400685371586439 0.299599232608792 0.407897779320763 0.504604597340595 NA NA NA 0.657739354417818 99.311357293691 a5833 PIK3CA_mut 300 CX-5461 RNA Pol I 17 32 2.32630161961136 NA 4.13803220504105 3.79247974632077 0.345552458720278 1.37874834273219 1.86144729609656 0.20178620892296 0.250627651189422 0.185636445063419 0.504655473737697 NA NA NA 0.465512055575437 99.311357293691 a5834 gain_cnaBRCA16 151 QS11 ARFGAP 16 32 2.32630161961136 NA 3.9641349599819 3.65860735914244 0.305527600839458 1.36227806320358 1.54053581569291 0.205775517957989 0.224276973322883 0.198325542143943 0.504907170797466 NA NA NA 0.488338016959462 99.311357293691 a5835 loss_cnaBRCA22_(SYNCRIP,ZNF292) 133 Doxorubicin DNA intercalating 18 30 0.0237165266173161 NA -0.800324597753072 -1.16883721500247 0.368512617249394 1.96686620574908 1.76147059826693 0.200273100963415 0.18736028722861 0.209207362082549 0.505111320904535 NA NA NA 0.518216405347884 99.311357293691 a5836 gain_cnaBRCA19 1241 CHIR-99021 GSK3B 4 42 2.30258509299405 NA 3.91681448440978 4.26145591230382 -0.344641427894035 1.27521405307056 0.955262414675535 0.351531497729546 0.270261629460701 0.360781940751952 0.505223305652846 NA NA NA 0.631549762839019 99.311357293691 a5837 BRCA2_mut 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 6 39 -0.669430653942629 NA -4.10867745926712 -3.39042441806375 -0.718253041203367 1.64607132013802 2.5237786733295 0.294606389275093 0.436343815979458 0.284594306463415 0.505300858077318 NA NA NA 0.383290050065446 99.311357293691 a5838 gain_cnaBRCA9_(KRAS) 292 Masitinib KIT 4 44 2.99573227355399 NA 4.36123920178986 3.97842630680863 0.382812894981233 1.25454450374669 1.08023737358432 0.350415792862926 0.305140944651994 0.3543784952663 0.50557908267127 NA NA NA 0.591545194766323 99.311357293691 a5839 gain_cnaBRCA30_(CRNKL1,FOXA2) 300 CX-5461 RNA Pol I 5 44 2.32630161961136 NA 4.39898278968891 3.85706785044359 0.54191493924532 1.27215924179495 1.74784446554529 0.316444378696016 0.425980428739965 0.31004757570134 0.505809032164454 NA NA NA 0.42129437754334 99.311357293691 a5840 ARID1A_mut 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 5 38 1.6094379124341 NA 3.37199853185964 2.88984186920901 0.482156662650628 0.748568158758592 1.57023637927931 0.319332820682849 0.64410522543495 0.307059923596932 0.505823949265765 NA NA NA 0.279417730312819 99.311357293691 a5841 BRCA1_mut 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 4 39 0.693147180559945 NA 2.60208691619677 2.93983733734365 -0.337750421146885 0.848410358638451 0.966846693475536 0.352308921725531 0.398097946009187 0.349331929690704 0.505954906803515 NA NA NA 0.497619945531007 99.311357293691 a5842 BRCA2_mut 293 MP470 PDGFR 6 42 2.99573227355399 NA 3.96017251820611 3.47035841222358 0.489814105982537 1.026718244075 1.7366446396642 0.292579032422982 0.477067694870684 0.282046248723198 0.505965700633227 NA NA NA 0.348700431105446 99.311357293691 a5843 gain_cnaBRCA58_(CCND1) 1373 Dabrafenib BRAF 9 37 2.30258509299405 NA 4.54328164141703 4.13463689940153 0.408644742015501 0.633234456561529 1.78802186303291 0.24921755028807 0.645329289619594 0.228545718855105 0.5060209661544 NA NA NA 0.265950728206623 99.311357293691 a5844 loss_cnaBRCA22_(SYNCRIP,ZNF292) 301 PHA-793887 CDK-pan 18 30 2.32630161961136 NA 2.71668916164067 3.04561835285016 -0.328929191209493 1.79674982717069 1.55113035710088 0.199813920402096 0.18306899838552 0.212057735640139 0.506083488907389 NA NA NA 0.523133779178501 99.311357293691 a5845 loss_cnaBRCA60 1218 JQ1 BRD2, BRD3, BRD4 3 43 0 NA 2.19450631489042 2.47636388762012 -0.281857572729708 1.29879584719942 0.662538469590481 0.400339796091605 0.217014531835373 0.425420689766023 0.506096113699017 NA NA NA 0.744159384607537 99.311357293691 a5846 loss_cnaBRCA29_(MAP2K4) 1203 QL-XII-61 BTK 3 20 2.30258509299405 NA 4.77817869280338 4.14226588985964 0.635912802943735 0.800490329912726 1.57523786396489 0.418755357338383 0.794404103561208 0.40369319293985 0.506199535804259 NA NA NA 0.325381578183016 99.311357293691 a5847 loss_cnaBRCA34 156 AZD6482 PI3Kbeta 5 42 1.63315443905142 NA 2.46840368575665 2.00389386339942 0.464509822357228 1.09213646354778 1.49735034306204 0.316882450687588 0.425322144128655 0.310221201410564 0.506394475022573 NA NA NA 0.423168006784294 99.311357293691 a5848 gain_cnaBRCA15 140 Vinorelbine Microtubules 22 25 -2.74887219562247 NA -3.42789264597391 -3.75111064911312 0.323218003139207 1.73276307167757 1.57562427243528 0.195792612154248 0.186533293802415 0.205136471171292 0.506423882845969 NA NA NA 0.509206962603578 99.311357293691 a5849 gain_cnaBRCA63 1 Erlotinib EGFR 3 9 0.693147180559945 NA 3.12518740173893 2.86036765883804 0.264819742900892 0.47950149290326 0.598364048961167 0.459313725217539 0.552281373093283 0.442572950966307 0.506511848432752 NA NA NA 0.477950153957394 99.311357293691 a5850 loss_cnaBRCA28_(GPS2) 1008 Methotrexate Dihydrofolate reductase (DHFR) 3 42 -1.6094379124341 NA 0.274455609734167 0.711806821928126 -0.437351212193959 0.803108058852231 1.10494574774758 0.400227301135057 0.544573307879643 0.395812385436565 0.506624222580103 NA NA NA 0.45082921715402 99.311357293691 a5851 MLL3_mut 1495 AZD-2281 PARP1, PARP2 3 42 2.30258509299405 NA 3.57542733160213 4.02892443733769 -0.453497105735559 0.747520701560637 1.14866316997833 0.400206197109848 0.606668289973468 0.394804253838932 0.506646518401896 NA NA NA 0.409155546050783 99.311357293691 a5852 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 172 Embelin XIAP 6 42 3.46573590279973 NA 2.7450949781608 3.02848606574458 -0.283391087583771 1.01955428218853 0.964272532511078 0.292025108339928 0.277955860256362 0.293891071278146 0.50676750851457 NA NA NA 0.543889411698751 99.311357293691 a5853 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1043 JNK Inhibitor VIII JNK 6 37 2.30258509299405 NA 4.98706667685978 4.76656326295754 0.220503413902239 1.12820264526896 0.678856015705139 0.294694457710121 0.195446637912882 0.324816174271061 0.50686764908581 NA NA NA 0.659265099759366 99.311357293691 a5854 PIK3CA_mut 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 16 31 2.99573227355399 NA 4.04211171275689 3.74730140352166 0.294810309235233 1.28688257767716 1.4986676799192 0.205936660505263 0.229088740767141 0.196714930991992 0.506913820521158 NA NA NA 0.486844072738251 99.311357293691 a5855 loss_cnaBRCA34 185 OSI-906 IGF1R 5 43 0.940007258491471 NA 2.57330688767765 2.93072049688958 -0.357413609211929 0.877941829276162 1.15217911519611 0.316022488837334 0.407103975791433 0.310206637577435 0.506945920875024 NA NA NA 0.439210343059759 99.311357293691 a5856 loss_cnaBRCA38 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 4 45 1.63315443905142 NA 3.25540689115295 3.60521245437495 -0.349805563221993 0.83838050797771 1.01286500188423 0.348886130452032 0.417239618399255 0.345362474338883 0.506967269586963 NA NA NA 0.478167629079312 99.311357293691 a5857 PTEN_mut 1031 Elesclomol HSP70 7 37 -1.6094379124341 NA -3.39289150174985 -2.89900644845578 -0.493885053294076 2.71002357073456 1.58634701599286 0.27582423815093 0.182243822019676 0.311334814082255 0.507029992849453 NA NA NA 0.654916445501169 99.311357293691 a5858 gain_cnaBRCA63 1373 Dabrafenib BRAF 6 40 2.30258509299405 NA 3.79701662717451 4.27722500718907 -0.480208380014568 3.98220633817595 1.00021259652144 0.29285450881993 0.120588522852517 0.480106311082912 0.507036862338162 NA NA NA 0.780364642885393 99.311357293691 a5859 gain_cnaBRCA16 184 BMS-754807 IGF1R 16 32 0.940007258491471 NA 1.85650021774013 1.51205332314975 0.344446894590382 1.86394683770537 1.58834167926333 0.204640707885049 0.184794376976125 0.216859444719814 0.507247854847461 NA NA NA 0.532140191502301 99.311357293691 a5860 gain_cnaBRCA14_(RAD21) 219 AT-7519 CDK9 21 28 2.32630161961136 NA 1.47180270085723 1.82214885524809 -0.350346154390861 1.95418002752088 1.70817958926009 0.192822486872313 0.179280388427323 0.205099133951492 0.50742823756575 NA NA NA 0.516207570039937 99.311357293691 a5861 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 111 Salubrinal GADD34-PP1C 4 9 2.77258872223978 NA 3.55726074558462 3.09455837953209 0.462702366052529 1.36529651323032 1.01955677940865 0.411495034533971 0.338902473981837 0.453826972070057 0.507661502070052 NA NA NA 0.572894783191606 99.311357293691 a5862 BRCA2_mut 1052 RO-3306 CDK1 5 38 1.6094379124341 NA 3.86421167989913 3.48112884496209 0.383082834937041 0.970592307489394 1.22756018371542 0.31793611191552 0.394689749734316 0.31206847535375 0.507676592324028 NA NA NA 0.453888931886682 99.311357293691 a5863 gain_cnaBRCA47_(EGFR) 203 BMS-345541 IKBKB 7 42 2.77258872223978 NA 3.29622953996199 3.57168257968331 -0.275453039721324 0.548450260427521 1.06182182995027 0.272481013533008 0.502238871227095 0.259415498864085 0.507755518052108 NA NA NA 0.313715409243906 99.311357293691 a5864 gain_cnaBRCA61_(NOTCH2) 309 Y-39983 ROCK 3 46 2.99573227355399 NA 4.52945378896239 4.96142834931449 -0.431974560352106 1.41151965462993 1.06952680651168 0.397665830389265 0.306035101201167 0.403893158845652 0.507806181078599 NA NA NA 0.651389915672794 99.311357293691 a5865 loss_cnaBRCA34 158 PF-562271 FAK 5 40 0.940007258491471 NA 2.6970475764119 2.28777553419646 0.409272042215438 0.849063202823293 1.32982835839909 0.316609593517314 0.482027769964041 0.307763058014599 0.50803747058901 NA NA NA 0.378166110947694 99.311357293691 a5866 gain_cnaBRCA9_(KRAS) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 38 1.38629436111989 0.693147180559945 3.10081471055111 3.46844190351277 -0.367627192961663 1.37780850813604 1.01601697528518 0.350958478112225 0.266820237203357 0.361831742878584 0.508187085209111 NA NA NA 0.636105593255681 99.311357293691 a5867 gain_cnaBRCA15 1047 Nutlin-3a MDM2 20 23 2.07944154167984 1.38629436111989 4.0969116736091 4.30262534584072 -0.205713672231627 1.03357004857368 0.985839434414355 0.204032550995727 0.199032153181597 0.208668536731676 0.508296765354075 NA NA NA 0.509854051100699 99.311357293691 a5868 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 194 AUY922 HSP90 9 38 -1.36257783450257 NA -2.04752314788302 -2.47574747855945 0.428224330676431 1.62528176950336 1.75473029123788 0.24718213190122 0.263476979014713 0.244039971735108 0.508318568722887 NA NA NA 0.496605518918797 99.311357293691 a5869 gain_cnaBRCA9_(KRAS) 1199 Tamoxifen ER 4 43 1.6094379124341 NA 4.17387784935944 3.8408253267523 0.333052522607139 0.557399388403734 0.978058186001212 0.34845726372353 0.597511460428628 0.34052424219138 0.508431645167584 NA NA NA 0.340877047026027 99.311357293691 a5870 gain_cnaBRCA12_(TERT) 1378 Bleomycin (50 uM) DNA damage 10 38 3.91202300542815 NA 3.45810177134499 3.90603757154581 -0.447935800200828 1.76675050637482 1.92026037305701 0.236851865485095 0.253536534210449 0.233268262203279 0.50847147495396 NA NA NA 0.494406097305056 99.311357293691 a5871 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 256 JW-7-24-1 LCK 7 41 2.32630161961136 NA 1.56598400402108 1.88393732064773 -0.317953316626649 0.70289294443256 1.22153485053849 0.272446280397563 0.452349563536066 0.260290008497495 0.508614067758597 NA NA NA 0.348392781359637 99.311357293691 a5872 loss_cnaBRCA18 62 BMS-536924 IGF1R 5 7 1.63315443905142 NA 3.41263775505861 2.98732382819198 0.42531392686663 0.729682846613419 1.23148847936431 0.401362248018503 0.582875051593419 0.345365737474195 0.508633559457897 NA NA NA 0.47192085239706 99.311357293691 a5873 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 226 GSK1070916 AURKB 15 34 0.940007258491471 2.32630161961136 2.68372528432216 2.2805164260712 0.403208858250954 1.69593900121684 2.05251744646183 0.206443237389393 0.237749623047558 0.196446007777431 0.508653825857803 NA NA NA 0.478131031051641 99.311357293691 a5874 ASH1L_mut 203 BMS-345541 IKBKB 3 46 2.77258872223978 NA 3.15571814809122 3.55689392787303 -0.401175779781806 0.140885210261615 1.03272196328513 0.396839072722534 2.84753650888442 0.38846445998461 0.508684697701573 NA NA NA 0.0281332227932807 99.311357293691 a5875 gain_cnaBRCA15 51 Dasatinib ABL, SRC, KIT, PDGFR 6 6 0.246860077931526 NA 1.73820453433124 2.19251654461024 -0.454312010278997 1.31102422683204 0.958005938506524 0.395685735777433 0.346532124258905 0.474226716159237 0.508699296676634 NA NA NA 0.510103883790236 99.311357293691 a5876 gain_cnaBRCA14_(RAD21) 1016 Temsirolimus MTOR 19 25 -1.6094379124341 NA -1.57773031175471 -1.88258105110933 0.304850739354615 1.20753372463807 1.69104919761531 0.202828556983116 0.25245732945967 0.180273134444882 0.508785546501868 NA NA NA 0.489465444016079 99.311357293691 a5877 gain_cnaBRCA48 136 Mitomycin C DNA crosslinker 5 43 2.77258872223978 NA -0.552184708556858 -0.0857146551540569 -0.466470053402802 1.83117510613358 1.44513351087838 0.314608990250787 0.254738092408719 0.32278682204198 0.5088388884468 NA NA NA 0.607931805198485 99.311357293691 a5878 POLR2B_mut 328 SNX-2112 HSP90 3 45 0.940007258491471 NA 1.17838040142349 0.366497260448453 0.811883140975035 1.15306702670101 2.07699459084723 0.396907925810992 0.704107499542227 0.390893238024206 0.508968719257692 NA NA NA 0.350691487951414 99.311357293691 a5879 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1026 17-AAG HSP90 8 35 0 NA -0.515420954439091 -0.983243380691396 0.467822426252305 1.82358713721121 1.78536164351861 0.261069536510758 0.256539661147062 0.262032304743768 0.509018210170854 NA NA NA 0.525477881934217 99.311357293691 a5880 gain_cnaBRCA30_(CRNKL1,FOXA2) 186 Bexarotene Retinioic acid X family agonist 5 42 2.07944154167984 NA 3.92581300184086 3.56614265989428 0.359670341946579 1.76514302124363 1.06341580864547 0.31457138315558 0.203762719291252 0.33822173699365 0.509484922079793 NA NA NA 0.676833786444562 99.311357293691 a5881 loss_cnaBRCA22_(SYNCRIP,ZNF292) 86 A-443654 AKT1, AKT2, AKT3 3 9 0.0237165266173161 NA -1.70829374050639 -1.13074155806513 -0.577552182441259 1.77496522470567 1.10371538012814 0.45593298403514 0.32538788614128 0.523279998484942 0.509575396142521 NA NA NA 0.638643338454376 99.311357293691 a5882 BRCA2_mut 1009 ATRA Retinoic acid and retinoid X receptor agonist 5 40 2.30258509299405 NA 4.43138393162859 4.06529423908047 0.366089692548115 0.994418734974829 1.17654055516312 0.315375704702023 0.368144404034566 0.311157733527816 0.509683728537623 NA NA NA 0.478838378891207 99.311357293691 a5883 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 221 TAK-715 p38a 9 40 2.99573227355399 2.32630161961136 4.28017991893718 4.52759659276126 -0.247416673824085 0.92944667959249 1.02500929729762 0.245116877911562 0.266197813448065 0.241379931359048 0.50968411845164 NA NA NA 0.49188256684303 99.311357293691 a5884 ARID1A_mut 230 GSK429286A ROCK2 5 44 2.99573227355399 2.32630161961136 5.65870389696699 5.37673082340736 0.281973073559634 0.736356670757012 0.91317092652779 0.313485557834896 0.382930018505504 0.308784549932835 0.509776847399541 NA NA NA 0.462187509342489 99.311357293691 a5885 gain_cnaBRCA61_(NOTCH2) 304 SB52334 ALK5 3 46 2.99573227355399 NA 4.77633996184529 4.27094947299302 0.505390488852267 1.31860419862357 1.27496309404469 0.395810214061472 0.383276869116464 0.396396171162074 0.509779115190892 NA NA NA 0.578769466437407 99.311357293691 a5886 PIK3CA_mut 1020 Lenalidomide TNFA 16 29 1.6094379124341 NA 4.34976451321665 4.20229185339035 0.147472659826304 0.832026365730825 0.639183516936295 0.207005937870906 0.177245176235214 0.230720373599688 0.509782089024704 NA NA NA 0.543617924713226 99.311357293691 a5887 loss_cnaBRCA33 111 Salubrinal GADD34-PP1C 4 9 2.77258872223978 NA 2.91816645257646 3.37860028753572 -0.460433834959255 0.655342136597564 1.25625690006672 0.409392219239685 0.702585427132394 0.366512482387004 0.509788813671968 NA NA NA 0.406058020492243 99.311357293691 a5888 loss_cnaBRCA20 207 AS601245 JNK 3 45 2.07944154167984 NA 2.74398804964142 2.2343482240511 0.509639825590317 0.818761909507829 1.30433590087923 0.395978529262573 0.622451801521482 0.390727438573744 0.509956641113735 NA NA NA 0.398713467022842 99.311357293691 a5889 gain_cnaBRCA27_(CLTC,PPM1D) 1017 Olaparib PARP1, PARP2 10 35 1.6094379124341 NA 4.23939584860682 4.02687016902093 0.212525679585896 0.935680203161442 0.880179013013413 0.238235770360703 0.22713495366026 0.241457335887032 0.50997676014441 NA NA NA 0.531508430628324 99.311357293691 a5890 gain_cnaBRCA8_(CHD4,WNK1) 260 NG-25 MAP3K7 (TAK1) 4 45 2.32630161961136 NA 3.61818289373469 3.17191322787005 0.446269665864639 1.49582660631546 1.27339303540629 0.346284114170433 0.298343179604149 0.350457127890801 0.510126031954998 NA NA NA 0.599159975407991 99.311357293691 a5891 loss_cnaBRCA42 261 TL-1-85 MAP3K7 (TAK1) 3 46 2.32630161961136 NA 3.57363673685617 4.05423057870922 -0.480593841853048 0.376501170145518 1.23942925912804 0.395467132729065 1.27647370037999 0.387754152416212 0.510144340249832 NA NA NA 0.144135965917532 99.311357293691 a5892 loss_cnaBRCA20 1043 JNK Inhibitor VIII JNK 3 40 2.30258509299405 NA 5.07413614244929 4.776570809081 0.29756533336829 0.0632657738762472 0.767121824231516 0.397650829932496 4.70341726871707 0.387898406705328 0.510223076007595 NA NA NA 0.0238485635382367 99.311357293691 a5893 loss_cnaBRCA20 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 3 40 1.6094379124341 NA 3.50444546780705 2.90401618214549 0.600429285661563 0.73286522470523 1.53937320686625 0.397619960177071 0.819290185181136 0.390047899355007 0.510255738806532 NA NA NA 0.294437763913495 99.311357293691 a5894 gain_cnaBRCA12_(TERT) 231 FMK RSK 9 40 2.99573227355399 2.32630161961136 5.47034275635101 5.61597925909621 -0.1456365027452 0.52697963978072 0.608054890560986 0.244752635976433 0.276360777061141 0.239512098341709 0.510310417071175 NA NA NA 0.479694686141597 99.311357293691 a5895 loss_cnaBRCA28_(GPS2) 309 Y-39983 ROCK 4 45 2.99573227355399 NA 5.28021254441826 4.90429367239291 0.375918872025347 0.536170107408449 1.11399871228776 0.346042239365718 0.701118668928283 0.337450005892144 0.510420198964694 NA NA NA 0.280595001070016 99.311357293691 a5896 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 287 KIN001-244 PDPK1 (PDK1) 6 43 2.99573227355399 NA 3.23833930321916 3.51156186585319 -0.273222562634028 1.00097631617803 0.93851472881888 0.289015598890029 0.272956071205818 0.291122295947213 0.510453374190104 NA NA NA 0.550253529239166 99.311357293691 a5897 gain_cnaBRCA64_(SDHC) 294 MPS-1-IN-1 MPS1 8 41 2.99573227355399 NA 5.00860614819621 4.70732971363867 0.301276434557535 1.26473145864853 1.15929012334719 0.256275990874412 0.238213758736952 0.259880101184393 0.510537001637572 NA NA NA 0.547084013493235 99.311357293691 a5898 gain_cnaBRCA10_(MDM2,NUP107) 1373 Dabrafenib BRAF 3 43 2.30258509299405 NA 3.60752629642279 4.25694235258934 -0.649416056166546 2.02609722890939 1.61920543982369 0.396011430753639 0.320525612937201 0.40107082164772 0.510682462362545 NA NA NA 0.637406944190322 99.311357293691 a5899 gain_cnaBRCA10_(MDM2,NUP107) 186 Bexarotene Retinioic acid X family agonist 4 43 2.07944154167984 NA 3.24185465345774 3.63813111885891 -0.396276465401177 1.43922358485242 1.11928047478241 0.346577688929246 0.275340447149364 0.35404572341728 0.510710295242145 NA NA NA 0.625679035997382 99.311357293691 a5900 loss_cnaBRCA17 1377 Afatinib (rescreen) ERBB2, EGFR 9 38 2.30258509299405 NA 3.23076443200381 2.74082121637086 0.489943215632951 1.51426070987281 2.08303390005752 0.245731820359582 0.323552749165699 0.235206549264235 0.510797829362716 NA NA NA 0.4316690650676 99.311357293691 a5901 loss_cnaBRCA17 304 SB52334 ALK5 11 38 2.99573227355399 NA 4.07724444179142 4.36692123114498 -0.289676789353556 1.19159431026049 1.29896916298588 0.226862994326988 0.243100178357037 0.223005131767477 0.510820922857806 NA NA NA 0.495886912738768 99.311357293691 a5902 gain_cnaBRCA12_(TERT) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 9 39 2.32630161961136 NA 4.81962077304478 4.99053724126927 -0.17091646822449 0.445990491679246 0.739991501420201 0.244930498867981 0.383228950870577 0.230970852903669 0.511063323425916 NA NA NA 0.379477757324261 99.311357293691 a5903 BRCA2_mut 1042 BIRB 0796 p38, JNK2 5 38 2.30258509299405 NA 4.62478373051609 4.3326234261998 0.292160304316287 0.474197108016146 0.96299770919182 0.315259477709538 0.61611574465009 0.3033862921247 0.511237269820896 NA NA NA 0.295416233273441 99.311357293691 a5904 loss_cnaBRCA42 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 3 44 2.77258872223978 NA 4.63075346674908 5.0368206658372 -0.406067199088118 0.853745058978544 1.03510465441532 0.395113066890492 0.475630511494794 0.392295790919312 0.511249115383543 NA NA NA 0.50180553095998 99.311357293691 a5905 BRCA1_mut 282 EKB-569 EGFR 4 43 0.916290731874155 2.99573227355399 2.24995486279736 1.51556629757359 0.734388565223765 1.9691476710266 2.13244311467962 0.346091729654134 0.37294743102781 0.344388349761021 0.511300330825943 NA NA NA 0.520974841798181 99.311357293691 a5906 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 53 CGP-60474 CDK1,CDK2,CDK5,CDK7,CDK9 3 9 -1.36257783450257 NA -1.18127734849018 -1.87319717321057 0.691919824720387 1.98842170659947 1.38431443462029 0.453893572200101 0.347974387135254 0.499828512523006 0.511428874107717 NA NA NA 0.619284075879768 99.311357293691 a5907 gain_cnaBRCA27_(CLTC,PPM1D) 53 CGP-60474 CDK1,CDK2,CDK5,CDK7,CDK9 3 9 -1.36257783450257 NA -1.18127734849018 -1.87319717321057 0.691919824720387 1.98842170659947 1.38431443462029 0.453893572200101 0.347974387135254 0.499828512523006 0.511428874107717 NA NA NA 0.619284075879768 99.311357293691 a5908 ASH1L_mut 1170 CCT018159 HSP90 3 40 2.30258509299405 NA 2.90214141091449 3.37587993520734 -0.473738524292849 1.30715076535215 1.18897246570574 0.396431112821016 0.362420722115573 0.39844364605336 0.511514501646657 NA NA NA 0.598178469929798 99.311357293691 a5909 gain_cnaBRCA9_(KRAS) 1175 AG-014699 PARP1, PARP2 3 40 1.6094379124341 NA 4.24124506996787 3.83309506694686 0.408150003021013 0.709965084247936 1.0434558701571 0.396378768901198 0.574887430490142 0.391152146146404 0.511569962497285 NA NA NA 0.430632848483266 99.311357293691 a5910 loss_cnaBRCA36_(FAT1,IRF2) 272 AR-42 HDAC 9 40 1.63315443905142 NA -0.163630134332321 0.210728340102563 -0.374358474434884 1.30985427147968 1.57637550159377 0.243995678064949 0.285801621284166 0.23748052038134 0.511613301813538 NA NA NA 0.469025998329634 99.311357293691 a5911 gain_cnaBRCA27_(CLTC,PPM1D) 1058 GDC0941 PI3K (class 1) 10 33 1.38629436111989 0.693147180559945 1.09089502994233 1.42330788457669 -0.332412854634359 1.43255864185549 1.37898491516388 0.238987454219843 0.232041359370678 0.241056193566015 0.511636624267288 NA NA NA 0.526916531671747 99.311357293691 a5912 loss_cnaBRCA29_(MAP2K4) 261 TL-1-85 MAP3K7 (TAK1) 7 42 2.32630161961136 NA 3.74371229769028 4.07165549398478 -0.3279431962945 0.956613469246577 1.24867127430753 0.269845094509636 0.342816829197258 0.262633731585093 0.511850530583085 NA NA NA 0.442467941258527 99.311357293691 a5913 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1243 piperlongumine Increases ROS levels 18 29 2.30258509299405 NA 1.81502935386368 1.64520995677042 0.169819397093263 0.789683598450277 0.893907423553664 0.19838095937576 0.215047390406141 0.1899742552961 0.511900377075002 NA NA NA 0.499884725638581 99.311357293691 a5914 ASH1L_mut 238 CAL-101 PI3Kdelta 3 46 2.99573227355399 2.32630161961136 5.06936919791319 4.69611172083543 0.373257477077761 0.334253918062711 0.966368829014175 0.393692112958547 1.11668841233368 0.386247430454202 0.512036180392583 NA NA NA 0.183947272914205 99.311357293691 a5915 gain_cnaBRCA14_(RAD21) 184 BMS-754807 IGF1R 21 27 0.940007258491471 NA 1.80892089266194 1.48527300291605 0.323647889745884 1.81823220711628 1.57175802099254 0.192262930423889 0.178001406244579 0.205914578085948 0.512040017765692 NA NA NA 0.520272703264744 99.311357293691 a5916 PIK3CA_mut 282 EKB-569 EGFR 16 31 0.916290731874155 2.99573227355399 1.29332514269323 1.72503122463749 -0.431706081944262 2.34526272372621 2.0010234690303 0.203444559945414 0.184075787150344 0.215742638017868 0.512043803048031 NA NA NA 0.535534067315163 99.311357293691 a5917 gain_cnaBRCA64_(SDHC) 1170 CCT018159 HSP90 8 35 2.30258509299405 NA 3.59482468399237 3.28522926197423 0.309595422018135 1.37479862138237 1.15455019290431 0.259069023672632 0.225193288095412 0.26815241461208 0.51225289366765 NA NA NA 0.568422482475996 99.311357293691 a5918 MLL3_mut 1192 GSK269962A ROCK1, ROCK2 3 43 1.6094379124341 NA 2.12685055273392 2.70569431848666 -0.578843765752746 1.61749869172063 1.4605110580485 0.39430475834987 0.357863514026707 0.396329601589037 0.512497016213788 NA NA NA 0.602125981391581 99.311357293691 a5919 PIK3CA_mut 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 4 10 1.38629436111989 NA 2.15218692860124 1.82794236000705 0.324244568594183 0.743240170680753 0.833852570851869 0.399243294605039 0.43625813214213 0.388851194957561 0.512567494502 NA NA NA 0.502395416001153 99.311357293691 a5920 POLR2B_mut 1261 rTRAIL TR10A (DR4), TR10B (DR5) 3 44 -2.30258509299405 NA -0.52407684061247 -0.114460063108215 -0.409616777504255 0.59084987955075 1.05645088762285 0.393789429327539 0.693267091491505 0.387729124281343 0.51265841912863 NA NA NA 0.357137801462571 99.311357293691 a5921 loss_cnaBRCA23 268 YM155 BIRC5 (Survivin) 3 46 1.63315443905142 NA -3.00412958748404 -3.63415072466112 0.630021137177074 1.33856745604596 1.61347865518323 0.393089753457475 0.47066820153996 0.39047379719165 0.512679040826697 NA NA NA 0.505485020788308 99.311357293691 a5922 ASH1L_mut 1261 rTRAIL TR10A (DR4), TR10B (DR5) 3 44 -2.30258509299405 NA -0.524050174151741 -0.114461881275992 -0.409588292875748 0.47422531861869 1.05918241772576 0.393761780329976 0.863699757888898 0.386702314937594 0.512687879877269 NA NA NA 0.273508923731686 99.311357293691 a5923 gain_cnaBRCA8_(CHD4,WNK1) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 3 45 2.77258872223978 NA -0.957174445881839 -0.401817385248889 -0.55535706063295 0.452343572063918 1.44039128891948 0.393344541923106 1.22773284496784 0.385559857869977 0.512762115154649 NA NA NA 0.156020464506964 99.311357293691 a5924 loss_cnaBRCA17 1264 SGC0946 Q8TEK3 (DOT1L) 9 37 -0.693147180559945 NA 1.83065069149366 1.97991816998184 -0.149267478488186 0.57389480387236 0.616246097720306 0.24519718748326 0.260095539253888 0.242220565842728 0.512873050513428 NA NA NA 0.502697434058798 99.311357293691 a5925 loss_cnaBRCA38 1170 CCT018159 HSP90 3 40 2.30258509299405 NA 3.78185587600184 3.30990135032579 0.471954525676047 1.16200621587004 1.19672676473077 0.394922359163188 0.406154906256398 0.394371162729216 0.513114401637111 NA NA NA 0.559379326600873 99.311357293691 a5926 loss_cnaBRCA17 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 9 37 0 NA 1.060362377666 0.554179332172763 0.506183045493233 1.70101619530495 2.13840793506381 0.245032167886767 0.297576852525197 0.236710235307899 0.513155365624834 NA NA NA 0.459892285636465 99.311357293691 a5927 BRCA1_mut 172 Embelin XIAP 4 44 3.46573590279973 NA 2.6869746415737 3.02088831963505 -0.333913678061346 0.533218353830228 0.993934796597823 0.344036125930141 0.626223151665295 0.335951290974329 0.513321887795267 NA NA NA 0.323258793527762 99.311357293691 a5928 loss_cnaBRCA24 1243 piperlongumine Increases ROS levels 3 44 2.30258509299405 NA 2.02529394046695 1.68876671123835 0.336527229228597 0.268115599148141 0.873826549968692 0.393113749588586 1.25515721687889 0.385119025326771 0.513378635128904 NA NA NA 0.150544608532823 99.311357293691 a5929 gain_cnaBRCA27_(CLTC,PPM1D) 303 PIK-93 PI4K, PI3K 9 40 2.99573227355399 NA 2.50874609450147 2.85515294832997 -0.346406853828495 1.80362352017397 1.33530972420547 0.242934613576811 0.192061619264692 0.259420602987529 0.513442631017469 NA NA NA 0.598527167808284 99.311357293691 a5930 ARID1A_mut 276 CAY10603 HDAC6 5 44 2.99573227355399 NA 1.45306325358866 1.14400298309792 0.309060270490733 1.18080140787776 0.97544885657076 0.310745216021531 0.261737721880093 0.316839030984412 0.513466625228627 NA NA NA 0.599024691174977 99.311357293691 a5931 loss_cnaBRCA17 341 EX-527 SIRT1 11 38 2.99573227355399 NA 5.52703884882915 5.67496003588676 -0.147921187057608 0.647645405515617 0.658746610706448 0.225352075525527 0.228398419563931 0.224549446863909 0.513626931627673 NA NA NA 0.515548816919211 99.311357293691 a5932 loss_cnaBRCA38 1033 Vismodegib SMO 3 42 2.30258509299405 NA 4.47146015019832 4.78036845678785 -0.308908306589534 0.229726481498796 0.802098429469597 0.393619911203527 1.34467870040117 0.385125185688003 0.513630759565166 NA NA NA 0.133971534743168 99.311357293691 a5933 gain_cnaBRCA15 53 CGP-60474 CDK1,CDK2,CDK5,CDK7,CDK9 6 6 -1.36257783450257 NA -1.99830141657268 -1.40213301748826 -0.596168399084419 1.72964757425786 1.28769513554241 0.390989386660196 0.344676226508291 0.462973247804728 0.513631611835332 NA NA NA 0.514866528554074 99.311357293691 a5934 gain_cnaBRCA19 133 Doxorubicin DNA intercalating 4 44 0.0237165266173161 NA -1.61049560448072 -0.9779312907206 -0.632564313760119 2.25865028970079 1.80762107313428 0.343708663247602 0.280062972406373 0.349942984822201 0.513721033311017 NA NA NA 0.620193754454873 99.311357293691 a5935 loss_cnaBRCA60 186 Bexarotene Retinioic acid X family agonist 3 44 2.07944154167984 NA 3.18397485032129 3.63307118576819 -0.449096335446904 1.5847966727165 1.11872333047349 0.392745683571619 0.283377888897955 0.401436461736102 0.513771190566588 NA NA NA 0.674246157092362 99.311357293691 a5936 gain_cnaBRCA30_(CRNKL1,FOXA2) 253 XMD14-99 EPHB3, CAMK1 5 43 2.32630161961136 NA 5.14898195423448 4.90799950138443 0.240982452850052 1.23164661121316 0.71687692455365 0.31081356625545 0.195658763362883 0.336155962894322 0.513940619849232 NA NA NA 0.688364992250906 99.311357293691 a5937 loss_cnaBRCA33 200 LAQ824 HDAC 6 42 0.0237165266173161 NA -3.039878661281 -2.63369437397127 -0.406184287309727 0.943172193410002 1.46197777650184 0.287090231829421 0.430657614959135 0.277832053153112 0.513941111800036 NA NA NA 0.386726743292468 99.311357293691 a5938 loss_cnaBRCA18 150 Bicalutamide ANDR (androgen receptor) 16 32 0.0237165266173161 NA 2.67863558958356 2.80456382038728 -0.125928230803719 0.562988753774836 0.653249642529077 0.20140457867362 0.223678057437863 0.192771985785073 0.513954969248216 NA NA NA 0.493767833995689 99.311357293691 a5939 loss_cnaBRCA60 185 OSI-906 IGF1R 3 45 0.940007258491471 NA 3.3094227586951 2.86576105619011 0.443661702504983 0.302432936067655 1.15477749191158 0.39222046914951 1.46697548313896 0.384196700760561 0.513961895609843 NA NA NA 0.110706447924626 99.311357293691 a5940 gain_cnaBRCA64_(SDHC) 1010 Gefitinib EGFR 9 36 -0.693147180559945 NA 1.19488489664981 1.45115104418592 -0.256266147536102 1.37120358632116 0.954759710715145 0.245258622156639 0.186891392417989 0.268409050633432 0.513983301838026 NA NA NA 0.607984570829997 99.311357293691 a5941 gain_cnaBRCA61_(NOTCH2) 225 Genentech Cpd 10 AURKA, AURKB 3 46 2.32630161961136 NA 3.61334546504542 2.97924070657291 0.634104758472509 0.98094846978726 1.64089108619488 0.391833842237287 0.646420049577148 0.38643927303119 0.514020791111645 NA NA NA 0.383983439487699 99.311357293691 a5942 loss_cnaBRCA28_(GPS2) 1003 Camptothecin TOP1 3 42 -2.30258509299405 NA -3.11403358326123 -2.48751343408427 -0.62652014917696 1.59599706722068 1.5932246625723 0.393208452000536 0.392557205802391 0.393240303075293 0.514068795460783 NA NA NA 0.571007341628005 99.311357293691 a5943 ARID1A_mut 344 THZ-2-49 CDK9 5 44 2.99573227355399 NA 2.19690323040396 1.73849905957654 0.458404170827421 1.28617384453659 1.49459619501074 0.310151083524975 0.356409184321877 0.306707706307339 0.514268493653933 NA NA NA 0.489558556341739 99.311357293691 a5944 gain_cnaBRCA47_(EGFR) 266 Zibotentan, ZD4054 Endothelin A Receptor 7 42 2.99573227355399 NA 5.62847170763515 5.76096733064763 -0.132495623012477 0.63807606412196 0.46903555303885 0.268292549678743 0.207648633858097 0.282485244783784 0.514270774288745 NA NA NA 0.614733031556006 99.311357293691 a5945 CDH1_mut 1022 AZD7762 CHEK1, CHEK2 4 41 0.693147180559945 NA 1.41562377770257 0.854909408341914 0.560714369360656 1.07209209710487 1.66192546919474 0.344477361828532 0.523009516509668 0.337388396624272 0.514286174089874 NA NA NA 0.393688200114411 99.311357293691 a5946 gain_cnaBRCA9_(KRAS) 262 VX-11e ERK 4 45 1.63315443905142 NA 4.19696886373948 3.73946466290246 0.457504200837025 0.633914343530894 1.36917716762357 0.342852488200508 0.72171296564885 0.334145362379288 0.514308108856547 NA NA NA 0.270990549418538 99.311357293691 a5947 loss_cnaBRCA20 200 LAQ824 HDAC 3 45 0.0237165266173161 NA -2.1649115971058 -2.71910446407027 0.55419286696447 0.984920140066806 1.43132683013072 0.391697350303349 0.562677971969261 0.387188205585343 0.514520761092044 NA NA NA 0.438043781118218 99.311357293691 a5948 gain_cnaBRCA48 1061 SB590885 BRAF 4 38 1.6094379124341 NA 4.35326996533568 3.97597924705471 0.377290718280966 0.836064322711996 1.10965377068984 0.34565756532383 0.451269965757089 0.340007602593389 0.514579745967607 NA NA NA 0.451608552232254 99.311357293691 a5949 loss_cnaBRCA38 1373 Dabrafenib BRAF 3 43 2.30258509299405 NA 4.81571102650797 4.17265039467642 0.64306063183155 0.263492874754217 1.67766150538051 0.392097752809563 2.44052379948182 0.383307735064051 0.514848675634215 NA NA NA 0.0423180850523316 99.311357293691 a5950 BRCA2_mut 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 5 38 1.6094379124341 NA 2.47252222180581 2.91999010417764 -0.447467882371827 1.41927844219393 1.43321577349417 0.312507686165515 0.315278432384365 0.312212501876743 0.514911981613706 NA NA NA 0.536536611585968 99.311357293691 a5951 gain_cnaBRCA58_(CCND1) 333 T0901317 LXR 10 38 2.32630161961136 NA 4.87699255349643 4.69818453564372 0.178808017852704 0.603946105341889 0.801301822864741 0.233218745488714 0.296066182513889 0.223146900144874 0.514966171641486 NA NA NA 0.448819116736905 99.311357293691 a5952 gain_cnaBRCA12_(TERT) 222 BX-912 PDPK1 (PDK1) 9 40 2.32630161961136 NA 3.58424214828117 3.95117697197725 -0.366934823696087 1.26044531615851 1.56332690833516 0.24203315340872 0.291115226493445 0.234714071471364 0.514999551650894 NA NA NA 0.463948764222727 99.311357293691 a5953 gain_cnaBRCA64_(SDHC) 309 Y-39983 ROCK 8 41 2.99573227355399 NA 5.16540713613746 4.8900197157623 0.275387420375168 1.32831129514098 1.03834870255787 0.25347445888097 0.207321447451774 0.265216703884521 0.515148832393225 NA NA NA 0.59327297039934 99.311357293691 a5954 loss_cnaBRCA38 226 GSK1070916 AURKB 4 45 0.940007258491471 2.32630161961136 1.79017439324293 2.45850533729514 -0.668330944052213 2.71672299857738 1.89016481114312 0.342136983486003 0.246006289342781 0.353583423049774 0.515182397798893 NA NA NA 0.660460040832221 99.311357293691 a5955 BRCA2_mut 288 KIN001-055 JAK3, MNK1 6 43 2.32630161961136 NA 4.12402744288582 4.36900413568188 -0.244976692796057 1.03625266196374 0.833887046380756 0.285624533151224 0.236406333887546 0.29377682967892 0.515404749790419 NA NA NA 0.599440745479513 99.311357293691 a5956 gain_cnaBRCA19 1066 AZD6482 PI3Kbeta 4 39 1.6094379124341 NA 2.41803488609583 1.92094689458299 0.497087991512837 1.91511443947207 1.39910135428086 0.344451668818145 0.259560463472807 0.355290908690701 0.515438345163882 NA NA NA 0.64475216192863 99.311357293691 a5957 BRCA2_mut 1007 Docetaxel Microtubules 5 40 -4.38202663467388 NA -4.15922301345254 -4.64078673578648 0.481563722333934 1.36330563980085 1.56594515130954 0.311044630688946 0.353232399452466 0.307522726406617 0.515485066066363 NA NA NA 0.494731184272856 99.311357293691 a5958 gain_cnaBRCA48 257 NPK76-II-72-1 PLK3 5 44 2.32630161961136 NA 3.92025250184423 3.42881345561667 0.491439046227567 0.899380561270238 1.63872538323771 0.309227012467653 0.546419466230718 0.299891031929101 0.515516996693498 NA NA NA 0.3302607377272 99.311357293691 a5959 NF1_mut 1133 JNJ-26854165 MDM2 5 38 2.30258509299405 NA 3.21011959553182 2.9370652789155 0.273054316616325 1.50566253844623 0.776960622044545 0.311996670236237 0.181351604123792 0.35143906765544 0.515595949980512 NA NA NA 0.709266522052279 99.311357293691 a5960 loss_cnaBRCA18 56 WH-4-023 SRC family, ABL 5 7 1.63315443905142 NA 3.48500643741465 3.03633993032726 0.448666507087392 0.91704200854855 1.26240279371638 0.39463395186667 0.489254039515071 0.355406776126157 0.515608900072096 NA NA NA 0.492127422295301 99.311357293691 a5961 loss_cnaBRCA22_(SYNCRIP,ZNF292) 35 NVP-TAE684 ALK 4 10 0.693147180559945 NA 1.42446399380836 1.91246486239664 -0.488000868588282 1.35581592674666 1.18705543123689 0.396292546901411 0.359931506158997 0.411102005640794 0.515632363004067 NA NA NA 0.55668448600827 99.311357293691 a5962 ARID1A_mut 1049 PD-173074 FGFR1, FGFR3 4 39 0.693147180559945 NA 3.29570855868123 2.90105172643439 0.394656832246833 0.795320257084052 1.16971768776472 0.344234687301436 0.496223790016108 0.337394942707078 0.515701585954367 NA NA NA 0.415093708816217 99.311357293691 a5963 PIK3CA_mut 62 BMS-536924 IGF1R 4 8 1.63315443905142 NA 3.45624072401144 3.0186865845739 0.43755413943754 1.26808020262769 0.957832952615398 0.412599872465663 0.345052417450292 0.456816753112098 0.5157265526385 NA NA NA 0.570421666172981 99.311357293691 a5964 loss_cnaBRCA20 172 Embelin XIAP 3 45 3.46573590279973 NA 3.34844083901855 2.96937026918181 0.379070569836742 0.519749417057532 0.986238807413305 0.390540811161433 0.729333323705839 0.384359819333173 0.515757487948271 NA NA NA 0.337433909218363 99.311357293691 a5965 loss_cnaBRCA24 288 KIN001-055 JAK3, MNK1 3 46 2.32630161961136 NA 4.02482021142938 4.35949743168147 -0.334677220252094 1.17238667228238 0.840979491533883 0.390205624011696 0.285466585525535 0.397961215013303 0.515763097644586 NA NA NA 0.672066952219979 99.311357293691 a5966 gain_cnaBRCA14_(RAD21) 328 SNX-2112 HSP90 21 27 0.940007258491471 NA 0.197985317804844 0.58777134261293 -0.389786024808086 1.97200034049382 2.1008649191725 0.190526669828459 0.197660221859028 0.185535976754572 0.515840236452282 NA NA NA 0.512583339526519 99.311357293691 a5967 gain_cnaBRCA47_(EGFR) 271 VNLG/124 HDAC, RAR 7 42 1.63315443905142 NA 3.96460297127423 4.18257962802342 -0.217976656749196 0.928374013908203 0.797673706931804 0.267283507348932 0.234794009185558 0.273265440310961 0.515847045725087 NA NA NA 0.574847241219031 99.311357293691 a5968 loss_cnaBRCA34 292 Masitinib KIT 5 43 2.99573227355399 NA 4.31318257543492 3.97511166115266 0.338070914282258 0.856569398460372 1.11258442694304 0.309388716194935 0.394680121528878 0.303860908076115 0.51586294747764 NA NA NA 0.452042054116443 99.311357293691 a5969 gain_cnaBRCA15 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 21 24 2.30258509299405 NA 1.48076466492222 1.26431344693831 0.216451217983909 1.00780273835148 1.18431681303416 0.195754500981639 0.2147753818748 0.18276462480455 0.515880144276238 NA NA NA 0.511310144728824 99.311357293691 a5970 gain_cnaBRCA62 165 DMOG Prolyl-4-Hydroxylase 9 37 8.29404964010203 NA 7.87146190671205 7.49664728167845 0.37481462503361 2.06747746770449 1.3956496058997 0.243424069774773 0.181290790776919 0.268559259752012 0.515910873285075 NA NA NA 0.617227142111242 99.311357293691 a5971 gain_cnaBRCA48 1058 GDC0941 PI3K (class 1) 4 39 1.38629436111989 0.693147180559945 0.911935561881441 1.39052226263918 -0.478586700757743 0.774817709517995 1.42844437891263 0.344041817778348 0.61767651265414 0.335040487276135 0.515935634921706 NA NA NA 0.332634574813332 99.311357293691 a5972 loss_cnaBRCA38 1019 Bosutinib SRC, ABL, TEC 3 42 0.693147180559945 NA 2.32041086074437 2.68704051420753 -0.366629653463151 1.11717706225389 0.927332789944937 0.391273615885284 0.32817506360494 0.395359311606916 0.5161312991418 NA NA NA 0.630186334151483 99.311357293691 a5973 loss_cnaBRCA7_(FAS,PTEN) 1091 BMS-536924 IGF1R 4 43 1.38629436111989 NA 3.36684547944214 2.9913447066133 0.375500772828838 0.689405448006663 1.12124064372328 0.342064184981135 0.544673347033382 0.334897575226956 0.516204569995981 NA NA NA 0.37723539691729 99.311357293691 a5974 gain_cnaBRCA48 207 AS601245 JNK 5 43 2.07944154167984 NA 1.90973929658147 2.30764971507713 -0.397910418495655 1.04885014383765 1.30765647976946 0.309124124070318 0.37937776033451 0.304292774632836 0.516220344035484 NA NA NA 0.466912505330207 99.311357293691 a5975 loss_cnaBRCA36_(FAT1,IRF2) 38 AZD-0530 SRC, ABL1 3 11 0.693147180559945 NA 2.81287742613374 2.52473704556441 0.288140380569329 0.833612441018271 0.62120443598617 0.435678392941533 0.345652687497515 0.463841472915277 0.516223555589855 NA NA NA 0.620672339044397 99.311357293691 a5976 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1375 Temozolomide DNA akylating agent 6 40 3.40119738166216 NA 5.72569742659081 5.9262902117404 -0.200592785149589 0.598619231721345 0.712162816466723 0.286484168377217 0.335092450292283 0.281667029661555 0.516275685071049 NA NA NA 0.479274323562346 99.311357293691 a5977 gain_cnaBRCA61_(NOTCH2) 312 AV-951 VEGFR 3 45 -2.05572501506252 NA 0.396976520733434 0.647962470262411 -0.250985949528978 0.408491153186065 0.652183100666633 0.390026724120471 0.614421995608447 0.384839701109137 0.516307729867779 NA NA NA 0.404045260025372 99.311357293691 a5978 gain_cnaBRCA8_(CHD4,WNK1) 1199 Tamoxifen ER 3 44 1.6094379124341 NA 3.51988913483082 3.89298484189306 -0.373095707062236 0.887836198002683 0.959016853608425 0.390281429695994 0.420230339674784 0.389039781374452 0.516403558060255 NA NA NA 0.546991635496359 99.311357293691 a5979 gain_cnaBRCA16 163 JQ1 BRD4 16 31 0.940007258491471 NA 0.510078339229073 0.215704308638612 0.294374030590461 1.32586403034514 1.52640293424117 0.201265572657675 0.222024298007264 0.192854733168346 0.516552081234801 NA NA NA 0.498326690031576 99.311357293691 a5980 gain_cnaBRCA30_(CRNKL1,FOXA2) 1377 Afatinib (rescreen) ERBB2, EGFR 5 42 2.30258509299405 NA 2.28360595377544 2.90023943669642 -0.616633482920984 3.1949875384648 1.83531745159608 0.309232240794743 0.193000277934504 0.33598192093947 0.516663478659866 NA NA NA 0.692291008121143 99.311357293691 a5981 PTEN_mut 1013 Nilotinib ABL 7 33 0.693147180559945 NA 2.98694086137174 3.24871846262486 -0.261777601253112 0.955128010246428 0.96217812061161 0.272381867644096 0.274075933743763 0.272067713498528 0.516689066520469 NA NA NA 0.527533578755583 99.311357293691 a5982 TP53_mut 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 37 10 2.32630161961136 NA 1.34075191295359 1.69881841963612 -0.358066506682529 1.49959391895235 1.67968670738297 0.232918899225995 0.238775645964663 0.213174578990634 0.51674882810823 NA NA NA 0.551322095270631 99.311357293691 a5983 ARID1A_mut 1033 Vismodegib SMO 5 40 2.30258509299405 NA 4.5434507427808 4.78681504804452 -0.243364305263717 1.09240159660502 0.746169391994693 0.310078660636035 0.222779155596302 0.326151552013069 0.516783776189179 NA NA NA 0.650962371516104 99.311357293691 a5984 gain_cnaBRCA19 1028 VX-702 p38 4 41 0.693147180559945 NA 3.21283890661341 3.44770875133571 -0.234869844722308 0.40353973135919 0.702547449292363 0.342411219833567 0.582024089502233 0.334311717961369 0.516800073485423 NA NA NA 0.353354252111153 99.311357293691 a5985 loss_cnaBRCA29_(MAP2K4) 1010 Gefitinib EGFR 6 39 -0.693147180559945 NA 1.65941227188928 1.35997251356937 0.299439758319907 0.985597251671294 1.05251559969662 0.286557672608674 0.303815537038219 0.284499116598574 0.516944085027581 NA NA NA 0.514911889287323 99.311357293691 a5986 gain_cnaBRCA19 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 4 42 0 NA 1.2979170369644 0.59181496527449 0.706102071689908 1.00302744227055 2.12295100856427 0.341777738952107 0.703970840609815 0.332604035063173 0.51705188147818 NA NA NA 0.282934534335551 99.311357293691 a5987 gain_cnaBRCA64_(SDHC) 288 KIN001-055 JAK3, MNK1 8 41 2.32630161961136 NA 4.15792526033016 4.37434000997548 -0.216414749645316 0.901936425981852 0.849743960732299 0.252314391655154 0.239944571935573 0.254682303901063 0.517065032496039 NA NA NA 0.545572889440557 99.311357293691 a5988 loss_cnaBRCA17 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 4 22 2.30258509299405 NA 4.38391551686585 4.74067836266512 -0.356762845799274 1.51535511976208 0.900692360375367 0.357320965120323 0.235431841122025 0.39609844769927 0.51719533221996 NA NA NA 0.675715475327919 99.311357293691 a5989 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 5 21 2.30258509299405 NA 2.36442405482393 2.76942797354223 -0.405003918718291 1.03815528253975 1.27485942259558 0.326997330232484 0.390118824736397 0.317685159273259 0.517349250146419 NA NA NA 0.478008896045462 99.311357293691 a5990 loss_cnaBRCA36_(FAT1,IRF2) 1166 QL-VIII-58 MTOR, ATR 3 23 2.30258509299405 NA -1.1164828561097 -1.5715328409919 0.455049984882197 1.11385089632115 1.12944364013333 0.403358583555708 0.408537611618527 0.402897469791833 0.5173712462755 NA NA NA 0.561137957824769 99.311357293691 a5991 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1018 ABT-888 PARP1, PARP2 17 28 1.6094379124341 NA 4.4863023224148 4.35254604142626 0.133756280988535 0.7821292294728 0.587291289249591 0.200691632500392 0.171015576388437 0.227751174650387 0.517411850816103 NA NA NA 0.547884978948525 99.311357293691 a5992 gain_cnaBRCA58_(CCND1) 1377 Afatinib (rescreen) ERBB2, EGFR 9 38 2.30258509299405 NA 2.44483853243651 2.92696156100522 -0.482123028568714 1.88366781451539 2.01720760799831 0.241772215895133 0.255949071727782 0.239005160726678 0.517599770195818 NA NA NA 0.508115391645878 99.311357293691 a5993 loss_cnaBRCA28_(GPS2) 202 GSK-1904529A IGF1R 4 44 0.0237165266173161 NA 2.4504136045523 2.16597086311632 0.284442741435983 0.395490771601597 0.857632460196135 0.340518220704547 0.719214610960684 0.331660419395661 0.517618590341622 NA NA NA 0.273694631206539 99.311357293691 a5994 gain_cnaBRCA27_(CLTC,PPM1D) 89 Parthenolide NFKB1 3 11 1.6094379124341 NA 3.73517052993081 3.1175097605921 0.617660769338709 1.7642570005451 1.34383599177965 0.434189306130768 0.350096822145453 0.459625112824025 0.517632921853906 NA NA NA 0.61694898221039 99.311357293691 a5995 gain_cnaBRCA61_(NOTCH2) 202 GSK-1904529A IGF1R 3 45 0.0237165266173161 NA 2.49410615511267 2.16937897622198 0.324727178890686 0.308383954634847 0.851563602005057 0.388743850897328 1.05299635084838 0.381330505585368 0.517682195291439 NA NA NA 0.203994503934575 99.311357293691 a5996 gain_cnaBRCA12_(TERT) 197 Bryostatin 1 PRKC 9 39 -4.8283137373023 NA -2.99666833896946 -2.76298905788774 -0.233679281081721 0.824346631586018 0.997115861233462 0.241084506432453 0.283472112492447 0.234355193981824 0.51768944836058 NA NA NA 0.474315835885951 99.311357293691 a5997 gain_cnaBRCA58_(CCND1) 223 ZSTK474 PI3K 10 39 1.63315443905142 2.32630161961136 0.645473441531617 0.980764761281484 -0.335291319749866 1.21024012022628 1.50343955266283 0.230935064851035 0.277045285597684 0.223016162609273 0.517887582315975 NA NA NA 0.468523060317344 99.311357293691 a5998 NF1_mut 1013 Nilotinib ABL 3 37 0.693147180559945 NA 3.55116957500708 3.17466990732976 0.376499667677313 0.784532167042761 0.969968438547611 0.39173786715905 0.479903416958036 0.388156616973092 0.517962104932705 NA NA NA 0.499892985500207 99.311357293691 a5999 gain_cnaBRCA64_(SDHC) 333 T0901317 LXR 8 40 2.32630161961136 NA 4.89663716224866 4.70319601478591 0.193441147462744 0.822266657009051 0.756352285837915 0.25228765993177 0.235253546782957 0.255755355123232 0.518027050346475 NA NA NA 0.552737592918378 99.311357293691 a6000 loss_cnaBRCA34 204 Tipifarnib Farnesyl-transferase (FNTA) 5 43 2.77258872223978 NA 1.20128811605273 1.66866122650697 -0.467373110454247 1.2136988761159 1.54445442131808 0.307774767728258 0.385081604384395 0.302613728189775 0.518045041389004 NA NA NA 0.461548226357041 99.311357293691 a6001 loss_cnaBRCA20 1010 Gefitinib EGFR 3 42 -0.693147180559945 NA 1.020053130675 1.42702957782182 -0.406976447146813 0.853416427808956 1.05343625874954 0.389457738480941 0.47687908726069 0.386332294684736 0.518071028687583 NA NA NA 0.501343190147185 99.311357293691 a6002 loss_cnaBRCA28_(GPS2) 1375 Temozolomide DNA akylating agent 4 42 3.40119738166216 NA 5.68219809589678 5.92088096775175 -0.238682871854973 0.575655853593318 0.708473404818734 0.340869175096864 0.414627716134707 0.336897433596736 0.518161222767991 NA NA NA 0.48229224639172 99.311357293691 a6003 gain_cnaBRCA14_(RAD21) 176 IPA-3 PAK1, PAK2, PAK3 21 26 3.46573590279973 NA 4.65688562589411 4.36757138486137 0.289314241032733 1.39866391472075 1.60033601388638 0.191089592357941 0.20685043632551 0.180783434555184 0.51816203198641 NA NA NA 0.512098119461779 99.311357293691 a6004 PTEN_mut 309 Y-39983 ROCK 9 40 2.99573227355399 NA 4.72193070711939 4.98291722678198 -0.260986519662595 1.19138239054624 1.06373415939311 0.240203822196499 0.219061924814026 0.245349382980701 0.518166771376179 NA NA NA 0.557297761841093 99.311357293691 a6005 loss_cnaBRCA7_(FAS,PTEN) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 4 41 -0.669430653942629 NA -4.24442495791273 -3.41221749337654 -0.832207464536198 1.6137784351363 2.4896431971847 0.341241311915614 0.515688799910075 0.334267763941943 0.518226431496584 NA NA NA 0.399565235847157 99.311357293691 a6006 loss_cnaBRCA42 268 YM155 BIRC5 (Survivin) 3 46 1.63315443905142 NA -4.17927800403371 -3.55751061053831 -0.621767393495394 2.31242724597408 1.56394860626921 0.387893245622539 0.268880845690556 0.397562548413029 0.51824292844749 NA NA NA 0.689056153366896 99.311357293691 a6007 gain_cnaBRCA9_(KRAS) 1502 Bicalutamide ANDR (androgen receptor) 4 41 2.30258509299405 NA 4.74025637381057 4.54055159725513 0.199704776555444 0.334324919760184 0.599965617555004 0.341167162646391 0.597337394707802 0.332860368514592 0.518316905638314 NA NA NA 0.343839684052455 99.311357293691 a6008 gain_cnaBRCA16 300 CX-5461 RNA Pol I 16 33 2.32630161961136 NA 3.68368382961481 4.02324115436744 -0.339557324752629 1.78604168282538 1.67764524343182 0.198225481165111 0.190117245312817 0.202401148921106 0.518411050605976 NA NA NA 0.52963553902308 99.311357293691 a6009 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1218 JQ1 BRD2, BRD3, BRD4 6 40 0 NA 2.63252383401178 2.43180057770665 0.200723256305132 0.409017557221362 0.733555581360315 0.285017506084623 0.490744841538671 0.273630603331936 0.518415485604152 NA NA NA 0.345366792064936 99.311357293691 a6010 NF1_mut 1199 Tamoxifen ER 5 42 1.6094379124341 NA 4.13223809294741 3.83785261864404 0.294385474303369 0.715594800895404 0.976299691254604 0.307931645631403 0.411385708692982 0.30153187278495 0.518420320338297 NA NA NA 0.437419740753497 99.311357293691 a6011 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1069 EHT 1864 Rac GTPases 7 39 2.30258509299405 NA 3.36626525321962 3.59644977162426 -0.23018451840464 0.570141065036508 0.898840931117663 0.267210366561408 0.403732571674872 0.256090383109743 0.518456251417086 NA NA NA 0.391622537346107 99.311357293691 a6012 gain_cnaBRCA12_(TERT) 1529 MLN4924 NEDD8-activating enzyme 7 30 0 NA -0.00945122902325381 0.457570789336759 -0.467022018360013 0.920848212288652 1.82675345938466 0.27375758483279 0.507165037763703 0.255656840807259 0.518538387295662 NA NA NA 0.34493265443744 99.311357293691 a6013 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1175 AG-014699 PARP1, PARP2 5 38 1.6094379124341 NA 4.14352666596782 3.82447117257734 0.319055493390476 1.10707146101076 1.02118071825865 0.309800005691527 0.288197740278823 0.312437835620847 0.518541631174155 NA NA NA 0.568143056464155 99.311357293691 a6014 gain_cnaBRCA61_(NOTCH2) 301 PHA-793887 CDK-pan 3 45 2.32630161961136 NA 2.32340160930653 2.96219445926927 -0.638792849962736 3.02302182083974 1.55539845880578 0.387937967531713 0.211309374467331 0.410694022709265 0.518546614673274 NA NA NA 0.750440588547214 99.311357293691 a6015 loss_cnaBRCA20 1008 Methotrexate Dihydrofolate reductase (DHFR) 3 42 -1.6094379124341 NA 0.285805840130088 0.71099609118556 -0.425190251055472 0.748912575995218 1.10712442811519 0.388987372209986 0.567743505295587 0.384049200124084 0.518574112012693 NA NA NA 0.435332621549933 99.311357293691 a6016 gain_cnaBRCA31 1164 XMD8-92 MAP2K5 (ERK5) 10 16 2.30258509299405 NA 4.09730749956834 3.75147741623303 0.345830083335317 1.52922951204847 1.15784799053599 0.264089700812836 0.226146618679928 0.298683494000993 0.518617219533809 NA NA NA 0.548419406126941 99.311357293691 a6017 gain_cnaBRCA16 133 Doxorubicin DNA intercalating 16 32 0.0237165266173161 NA -0.786284346565232 -1.1528253020183 0.366540955453066 1.79484199904818 1.8623515857981 0.199141056308563 0.204219065325776 0.19681619638753 0.51867446078862 NA NA NA 0.514983768231087 99.311357293691 a6018 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1066 AZD6482 PI3Kbeta 7 36 1.6094379124341 NA 2.29210455446609 1.90400934866271 0.388095205803382 0.838708783015728 1.52297230370341 0.268904660572448 0.462729392683735 0.254827487577845 0.518694539150546 NA NA NA 0.354299281946868 99.311357293691 a6019 gain_cnaBRCA13_(FGFR1,WHSC1L1) 333 T0901317 LXR 11 37 2.32630161961136 NA 4.8674431498801 4.69619089839851 0.171252251481595 0.72127355453478 0.778923331825377 0.223345435276211 0.23743037631825 0.21985764771004 0.518695067569664 NA NA NA 0.506261078049253 99.311357293691 a6020 loss_cnaBRCA24 176 IPA-3 PAK1, PAK2, PAK3 3 44 3.46573590279973 NA 5.04683384377577 4.45933983224647 0.587494011529295 0.601468614405407 1.54341505239361 0.388029109096054 0.976765865181632 0.380645511146323 0.51881584088158 NA NA NA 0.22998436162186 99.311357293691 a6021 gain_cnaBRCA16 287 KIN001-244 PDPK1 (PDK1) 16 33 2.99573227355399 NA 3.6041990414957 3.41697004203245 0.187228999463253 1.13542538963894 0.8418960590354 0.198015243325554 0.164897668461325 0.222389685108836 0.518852805584816 NA NA NA 0.563456587114312 99.311357293691 a6022 gain_cnaBRCA47_(EGFR) 1050 ZM-447439 AURKB 6 33 1.38629436111989 0.693147180559945 2.56459639191179 2.94671093422222 -0.382114542310426 0.530475138670474 1.40587540585721 0.289064558167654 0.720325071723656 0.271798297856585 0.518864382081202 NA NA NA 0.255603627616986 99.311357293691 a6023 TP53_mut 273 CUDC-101 HDAC, EGFR 38 11 1.63315443905142 NA -0.105245759760056 0.244869256131048 -0.350115015891104 1.530861165821 1.7210017823163 0.22254359990655 0.228704616530879 0.203436753807358 0.518864625788675 NA NA NA 0.551949867937432 99.311357293691 a6024 gain_cnaBRCA30_(CRNKL1,FOXA2) 211 TL-2-105 CRAF 5 44 2.32630161961136 1.63315443905142 3.60690790596508 3.94171803544634 -0.334810129481263 1.37694109707358 1.06104693014655 0.306744073223193 0.243155012362429 0.315546956471584 0.51887969809817 NA NA NA 0.623308138925565 99.311357293691 a6025 loss_cnaBRCA17 167 OSU-03012 PDPK1 (PDK1) 11 37 2.77258872223978 NA 2.04361205332655 2.30873677668797 -0.26512472336142 0.867763456654708 1.26214265840647 0.22324383560945 0.305526490345071 0.210059236644577 0.518884422655477 NA NA NA 0.435034520066191 99.311357293691 a6026 gain_cnaBRCA27_(CLTC,PPM1D) 310 YM201636 FYV1 9 40 1.63315443905142 NA 2.21505975983301 2.45957922169189 -0.244519461858879 1.23671133055938 0.969559201439944 0.239728404019957 0.197717491395732 0.25219652548883 0.518991587303551 NA NA NA 0.590085194669133 99.311357293691 a6027 loss_cnaBRCA36_(FAT1,IRF2) 1003 Camptothecin TOP1 8 37 -2.30258509299405 NA -2.86136945936552 -2.45747862990267 -0.403890829462853 0.718031364311922 1.71257154270296 0.253454476828482 0.562497475092742 0.235838806958914 0.519124838690473 NA NA NA 0.296163342187903 99.311357293691 a6028 gain_cnaBRCA19 1219 PFI-1 BRD2, BRD3, BRD4 4 43 2.30258509299405 NA 2.86141578189183 3.20141736760397 -0.340001585712136 0.895760962135028 1.00807217577265 0.339669767426558 0.379567317715822 0.337279010256918 0.519132099265552 NA NA NA 0.514980918919042 99.311357293691 a6029 loss_cnaBRCA28_(GPS2) 151 QS11 ARFGAP 4 44 2.32630161961136 NA 4.22212345794183 3.71847956864775 0.503643889294076 1.62930052240066 1.4746663564839 0.339098868719167 0.309116631566528 0.341530738176554 0.519357587492826 NA NA NA 0.587670400269796 99.311357293691 a6030 gain_cnaBRCA27_(CLTC,PPM1D) 1042 BIRB 0796 p38, JNK2 10 33 2.30258509299405 NA 4.53348707200075 4.31602236752017 0.21746470448058 0.682947735063651 0.984701959942831 0.234610786984879 0.318420712619118 0.220843172174863 0.519358643176755 NA NA NA 0.438894598951536 99.311357293691 a6031 gain_cnaBRCA62 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 10 38 2.32630161961136 NA 4.83101875778951 4.99203557339499 -0.161016815605481 0.92595385314742 0.630131529059377 0.230700805783052 0.17389291600026 0.255528898618733 0.519493315026043 NA NA NA 0.613669837828343 99.311357293691 a6032 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 176 IPA-3 PAK1, PAK2, PAK3 6 41 3.46573590279973 NA 4.12208889640932 4.5516809944321 -0.429592098022782 1.37684013389622 1.53036018820399 0.283733069325525 0.31201305616151 0.280713064371431 0.519556818390218 NA NA NA 0.504742560594448 99.311357293691 a6033 loss_cnaBRCA33 140 Vinorelbine Microtubules 6 41 -2.74887219562247 NA -4.0084940648964 -3.5400107329238 -0.468483331972602 0.793494457329192 1.72886980427114 0.283703254044133 0.59040529854419 0.270976640817731 0.519600500007229 NA NA NA 0.285941985032141 99.311357293691 a6034 loss_cnaBRCA22_(SYNCRIP,ZNF292) 328 SNX-2112 HSP90 18 30 0.940007258491471 NA 0.664608096118438 0.268819073143966 0.395789022974472 2.0349774235689 2.05244448131953 0.193444642875469 0.19449307810027 0.192837870440236 0.519672620909569 NA NA NA 0.519637750975364 99.311357293691 a6035 POLR2B_mut 301 PHA-793887 CDK-pan 3 45 2.32630161961136 NA 2.32506447559659 2.9620836015166 -0.637019125920005 1.49744812314757 1.65314175201018 0.386850917438827 0.425403134888587 0.385338477565766 0.519713843000893 NA NA NA 0.542609476106173 99.311357293691 a6036 BRCA1_mut 151 QS11 ARFGAP 4 44 2.32630161961136 NA 4.22163369012296 3.71852409299492 0.503109597128045 1.3879888976532 1.4918059170274 0.338735842716765 0.362473790661221 0.337248693939054 0.519802868490007 NA NA NA 0.531635094267402 99.311357293691 a6037 loss_cnaBRCA20 193 GW-2580 CSF1R (cFMS) 3 45 2.99573227355399 NA 5.73459546129115 5.44530842794367 0.289287033347485 0.0622459601567927 0.764711544884949 0.38673948209615 4.64748286665983 0.378295627001431 0.51983357662059 NA NA NA 0.0197371008681657 99.311357293691 a6038 loss_cnaBRCA23 211 TL-2-105 CRAF 3 46 2.32630161961136 1.63315443905142 4.30348722581829 3.8817319872176 0.421755238600692 0.955430340634908 1.09717610688145 0.38639279618414 0.441429605763226 0.384400677298254 0.51985543146944 NA NA NA 0.529195900409965 99.311357293691 a6039 gain_cnaBRCA13_(FGFR1,WHSC1L1) 224 AS605240 PI3Kgamma 11 38 2.99573227355399 2.32630161961136 3.54316144204558 3.19125802248336 0.351903419562222 1.32881343000278 1.64783994998377 0.221972393515515 0.264825303249295 0.21355436829025 0.519933377614872 NA NA NA 0.473551806779488 99.311357293691 a6040 gain_cnaBRCA8_(CHD4,WNK1) 268 YM155 BIRC5 (Survivin) 4 45 1.63315443905142 NA -4.093457795491 -3.5513220203311 -0.542135775159898 0.971815645026917 1.63719238349194 0.338201845442037 0.557858661706235 0.331137489171301 0.520005022069227 NA NA NA 0.367432323270348 99.311357293691 a6041 gain_cnaBRCA47_(EGFR) 228 KIN001-102 AKT1 7 42 2.32630161961136 NA 2.26345912224475 1.89041100826934 0.373048113975416 1.29227200803221 1.4274479028924 0.264401979812532 0.28867615459958 0.261339214705854 0.520362617640253 NA NA NA 0.504579747886622 99.311357293691 a6042 loss_cnaBRCA29_(MAP2K4) 203 BMS-345541 IKBKB 7 42 2.77258872223978 NA 3.30320479929884 3.5705200364605 -0.26731523716166 0.950320693815802 1.01978860542289 0.264358093138488 0.28128950458641 0.262128087860728 0.520431553619623 NA NA NA 0.513630949785083 99.311357293691 a6043 NF1_mut 345 KIN001-270 CDK9 5 44 2.99573227355399 NA 5.29755242396936 5.08600000683658 0.211552417132781 0.551731185132067 0.704003065802209 0.305557567876067 0.383433858432602 0.300499283894052 0.520490729573384 NA NA NA 0.462948355033549 99.311357293691 a6044 NF1_mut 1175 AG-014699 PARP1, PARP2 5 38 1.6094379124341 NA 3.58092575720165 3.89849760794131 -0.317571850739656 1.2562405053852 1.00240270457125 0.308344606134158 0.252795423629713 0.316810648346654 0.520498247488446 NA NA NA 0.611911470177161 99.311357293691 a6045 loss_cnaBRCA7_(FAS,PTEN) 221 TAK-715 p38a 4 45 2.99573227355399 2.32630161961136 4.16901705460418 4.50998699472152 -0.340969940117343 1.05530244272236 1.00643115165903 0.33772063586662 0.323101630692471 0.33879112302444 0.52059640298942 NA NA NA 0.572363219335265 99.311357293691 a6046 gain_cnaBRCA14_(RAD21) 1046 681640 WEE1, CHEK1 17 19 0.693147180559945 NA 2.75622774485571 2.52424969195196 0.231978052903751 1.12431457609296 1.02077427579663 0.216650657633494 0.206328422522 0.227256954259267 0.520731594250009 NA NA NA 0.523201193987352 99.311357293691 a6047 loss_cnaBRCA34 221 TAK-715 p38a 5 44 2.99573227355399 2.32630161961136 4.20530496123362 4.51361268578903 -0.308307724555406 0.915199063370686 1.01796309948665 0.305368696655863 0.33687504379638 0.302867289306344 0.520747423299131 NA NA NA 0.510975809204711 99.311357293691 a6048 loss_cnaBRCA36_(FAT1,IRF2) 208 SB-715992 KIF11 9 40 -2.05572501506252 NA -0.906066529048314 -1.31501165333375 0.408945124285436 1.66530750503953 1.72276105471411 0.238713953420379 0.245567333989604 0.237377739162614 0.520753922566031 NA NA NA 0.520700645150364 99.311357293691 a6049 gain_cnaBRCA47_(EGFR) 172 Embelin XIAP 7 41 3.46573590279973 NA 2.77363594875194 3.03052519485301 -0.256889246101065 0.804410587832522 0.993286602650211 0.264633224453614 0.319350901127807 0.258625501859839 0.520789891259221 NA NA NA 0.470038817373412 99.311357293691 a6050 gain_cnaBRCA48 1091 BMS-536924 IGF1R 5 42 1.38629436111989 NA 2.72297353140416 3.05905563440761 -0.33608210300345 1.2930005579313 1.07693501180494 0.306123591994872 0.259924174774645 0.312072779990853 0.520867928476699 NA NA NA 0.602072874471311 99.311357293691 a6051 gain_cnaBRCA19 170 Shikonin unknown 4 43 2.77258872223978 NA -0.364648601836202 0.0378644358499358 -0.402513037686138 0.637595096485803 1.22027940584931 0.338149370514771 0.631298828840821 0.329853176048636 0.520995598773168 NA NA NA 0.322200400399784 99.311357293691 a6052 loss_cnaBRCA34 229 LY317615 PRKCB (PKCbeta) 5 44 2.99573227355399 2.32630161961136 2.91502755471921 3.40898710806092 -0.49395955334171 1.18038637587974 1.65356204312407 0.305160870620679 0.418472767422076 0.298724535553848 0.521029956161622 NA NA NA 0.430158899363292 99.311357293691 a6053 gain_cnaBRCA8_(CHD4,WNK1) 301 PHA-793887 CDK-pan 4 44 2.32630161961136 NA 2.41249358736707 2.96861320785383 -0.556119620486753 1.5563863737095 1.65284539873487 0.33771212677011 0.357314629503787 0.33646197092143 0.521059634301276 NA NA NA 0.536899726462456 99.311357293691 a6054 loss_cnaBRCA34 294 MPS-1-IN-1 MPS1 5 44 2.99573227355399 NA 5.07868573209003 4.7199076996433 0.358778032446734 0.727439829854248 1.2091505842571 0.30511917083314 0.493206472511438 0.296719066357783 0.521086655503791 NA NA NA 0.368752125502611 99.311357293691 a6055 loss_cnaBRCA17 88 MS-275 HDAC 4 10 1.6094379124341 NA 0.637239490661487 1.33994547535252 -0.702705984691033 1.29759628152928 1.93499831142734 0.391050379365742 0.541544388415523 0.363155864550955 0.521103668263303 NA NA NA 0.452206116210828 99.311357293691 a6056 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1170 CCT018159 HSP90 5 38 2.30258509299405 NA 3.66803146615361 3.30003853448077 0.367992931672842 0.742365309707911 1.23434385431253 0.307868229335848 0.495703297097262 0.298128378398898 0.521139536932661 NA NA NA 0.372761504323662 99.311357293691 a6057 gain_cnaBRCA16 219 AT-7519 CDK9 16 33 2.32630161961136 NA 1.43097997790656 1.78885893995283 -0.357878962046273 1.99275350267675 1.7292149305867 0.19690948829274 0.179590180905744 0.20696037011712 0.521179534796424 NA NA NA 0.543941980057721 99.311357293691 a6058 gain_cnaBRCA14_(RAD21) 1114 Cetuximab EGFR 19 26 4.18661983833127 NA 6.38188510402397 6.21001963478973 0.171865469234238 0.589671006868507 1.04085292070131 0.195172812335397 0.291459928048595 0.165119841445454 0.521288456632321 NA NA NA 0.486772024818695 99.311357293691 a6059 gain_cnaBRCA13_(FGFR1,WHSC1L1) 87 GW843682X PLK1 3 9 -1.36257783450257 NA -2.56534789356636 -1.69782035656882 -0.867527536997544 2.61501009107946 1.75546298409839 0.44311375468701 0.331749211965539 0.494187314033915 0.521293196654552 NA NA NA 0.634047040224361 99.311357293691 a6060 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 13 13 2.30258509299405 NA 4.81324359326466 4.55833994874273 0.254903644521934 0.658059721280488 1.24956736941895 0.255257343941468 0.387356399850654 0.203993518685163 0.521370172470435 NA NA NA 0.523328197355178 99.311357293691 a6061 gain_cnaBRCA12_(TERT) 225 Genentech Cpd 10 AURKA, AURKB 9 40 2.32630161961136 NA 3.33299120985214 2.94720470022053 0.385786509631612 1.43505533702986 1.65368251712905 0.238352245345501 0.268830406519427 0.233289344015907 0.521383061804378 NA NA NA 0.491408221457227 99.311357293691 a6062 loss_cnaBRCA33 1129 PF-4708671 RPS6KB1 (p70S6KA) 4 39 2.30258509299405 NA 3.45517244899092 3.84525353610088 -0.390081087109959 0.888324346763481 1.16690128477666 0.339552162254706 0.439120112525542 0.334287991794111 0.521399979382181 NA NA NA 0.462122424155809 99.311357293691 a6063 loss_cnaBRCA7_(FAS,PTEN) 1494 SN-38 TOP1 4 44 -2.99573227355399 NA -3.82589867107628 -3.2563239498188 -0.569574721257484 0.829170953876774 1.73277421078334 0.337296458355596 0.686920735216842 0.328706831918969 0.521570390922626 NA NA NA 0.290744568207056 99.311357293691 a6064 loss_cnaBRCA42 293 MP470 PDGFR 3 45 2.99573227355399 NA 2.92694873349531 3.57189427160313 -0.644945538107826 1.96589554130225 1.66025926246763 0.385109233056916 0.328067043521854 0.388460737842382 0.521586904508087 NA NA NA 0.630181179149511 99.311357293691 a6065 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1043 JNK Inhibitor VIII JNK 8 35 2.30258509299405 NA 4.95166638184205 4.76205456388147 0.18961181796058 0.894718072014215 0.714717435132381 0.25331570181658 0.211923536465203 0.265296197686097 0.521617207762468 NA NA NA 0.588947620498544 99.311357293691 a6066 loss_cnaBRCA38 258 STF-62247 stimulates autophagy 4 45 2.32630161961136 NA 4.92905527387264 4.60433513929407 0.324720134578572 0.361336569236662 0.992046590155381 0.336778520450903 0.898663911224255 0.327323472305583 0.521755247418236 NA NA NA 0.201219018877156 99.311357293691 a6067 BRCA2_mut 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 6 41 2.32630161961136 NA 1.03845616518349 1.4723236093791 -0.433867444195607 1.61646213829328 1.527314565089 0.282194771536049 0.268405571598293 0.284072092359262 0.521813093574406 NA NA NA 0.557794994278474 99.311357293691 a6068 gain_cnaBRCA58_(CCND1) 1033 Vismodegib SMO 9 36 2.30258509299405 NA 4.91087332500198 4.72199988085185 0.188873444150127 0.596060979334707 0.822043060622713 0.240621038434405 0.316869331659552 0.229761010338134 0.521934165324566 NA NA NA 0.444916899908993 99.311357293691 a6069 loss_cnaBRCA17 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 11 37 2.07944154167984 NA 3.41323452999884 3.15516177862685 0.258072751371982 1.22960410293319 1.1459160110606 0.221593811766064 0.209882799476967 0.225210878354971 0.521964789089257 NA NA NA 0.543869533570075 99.311357293691 a6070 loss_cnaBRCA36_(FAT1,IRF2) 1527 GDC0941 (rescreen) PI3K 9 36 1.38629436111989 NA 1.20386216734202 0.924854259869013 0.279007907473009 1.44962256583456 1.08284478150296 0.24054527510988 0.192469346193147 0.257661958795011 0.522064598615822 NA NA NA 0.600025125199108 99.311357293691 a6071 gain_cnaBRCA31 1241 CHIR-99021 GSK3B 14 32 2.30258509299405 NA 4.37248943517851 4.16979856755938 0.202690867619128 0.956920823661244 0.990628695642953 0.206660793820097 0.211815714118979 0.204608314407422 0.522315874752257 NA NA NA 0.518970273005402 99.311357293691 a6072 loss_cnaBRCA34 1091 BMS-536924 IGF1R 5 42 1.38629436111989 NA 2.72406104568823 3.05892616842141 -0.334865122733183 0.703245749820232 1.1290421319219 0.305004836124701 0.476170844713649 0.296592229169662 0.522385492086004 NA NA NA 0.383664141273486 99.311357293691 a6073 gain_cnaBRCA27_(CLTC,PPM1D) 229 LY317615 PRKCB (PKCbeta) 9 40 2.99573227355399 2.32630161961136 3.04443203778466 3.42926705470536 -0.384835016920699 1.69439522651158 1.60277301034665 0.237738186359483 0.227122344833913 0.240105750743498 0.522452053044662 NA NA NA 0.546345478936644 99.311357293691 a6074 BRCA2_mut 1058 GDC0941 PI3K (class 1) 5 38 1.38629436111989 0.693147180559945 1.72328133055984 1.2963606273067 0.426920703253138 0.642539598001977 1.4492536773269 0.306851131788978 0.664427071235264 0.29457969293587 0.522510144813364 NA NA NA 0.275398818164968 99.311357293691 a6075 loss_cnaBRCA23 261 TL-1-85 MAP3K7 (TAK1) 3 46 2.32630161961136 NA 3.58672992347375 4.05337667523416 -0.466646751760411 0.655705179007002 1.23458616430771 0.383887590344138 0.711671596779363 0.377978277459541 0.522553667693734 NA NA NA 0.347044003017157 99.311357293691 a6076 loss_cnaBRCA36_(FAT1,IRF2) 1066 AZD6482 PI3Kbeta 8 35 1.6094379124341 NA 2.26409225587331 1.8993237253181 0.364768530555211 1.16419229569438 1.49440161293224 0.252717912998011 0.313323264467787 0.244090027338421 0.522595403042161 NA NA NA 0.463637638517923 99.311357293691 a6077 loss_cnaBRCA17 1203 QL-XII-61 BTK 3 20 2.30258509299405 NA 4.75725034815783 4.14540514155647 0.611845206601359 0.685323773104142 1.58224831624401 0.402581096406541 0.892782697191482 0.386693542549489 0.522596061417746 NA NA NA 0.292401666349837 99.311357293691 a6078 loss_cnaBRCA38 178 BAY 61-3606 SYK 4 44 2.07944154167984 NA 2.59876425103309 3.14093360080829 -0.542169349775197 1.50634480315154 1.61854800506235 0.336444261037564 0.359923802731541 0.334972671851219 0.522618368000959 NA NA NA 0.534355769401661 99.311357293691 a6079 gain_cnaBRCA12_(TERT) 211 TL-2-105 CRAF 9 40 2.32630161961136 1.63315443905142 4.11929531318779 3.85991188176935 0.259383431418437 0.889924700805084 1.1285050319007 0.237621065285711 0.291466717559116 0.229846942712844 0.522656076460387 NA NA NA 0.465706073404305 99.311357293691 a6080 MLL3_mut 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 3 40 0.693147180559945 NA 3.25270197707081 2.88259744724943 0.370104529821379 0.730593235348802 0.969345217642896 0.385895897631684 0.506580833101586 0.381808795344699 0.522742345569301 NA NA NA 0.479313812252341 99.311357293691 a6081 loss_cnaBRCA22_(SYNCRIP,ZNF292) 345 KIN001-270 CDK9 19 30 2.99573227355399 NA 5.18761629130428 5.05690176286249 0.130714528441795 0.730445907059764 0.667666037161427 0.188789531396677 0.17895168852127 0.195778310062807 0.522771265597944 NA NA NA 0.532174816612137 99.311357293691 a6082 loss_cnaBRCA33 344 THZ-2-49 CDK9 6 43 2.99573227355399 NA 1.42135337289672 1.83605475665133 -0.414701383754608 1.26191689312415 1.50195835580531 0.280530433647845 0.328628125999586 0.276107111859474 0.522890864924082 NA NA NA 0.485463809402675 99.311357293691 a6083 BRCA1_mut 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 4 45 3.68887945411394 NA 3.09012003386447 3.49228871310639 -0.402168679241918 0.771245018499596 1.22253277024641 0.335472194356062 0.521453843584377 0.328963516586028 0.523364350603316 NA NA NA 0.393799042591459 99.311357293691 a6084 BRCA2_mut 301 PHA-793887 CDK-pan 6 42 2.32630161961136 NA 2.51795716071215 2.98002886978009 -0.462071709067946 1.59162778588239 1.65341692301646 0.280585411875704 0.290313924628914 0.279464727036271 0.523479612040588 NA NA NA 0.530306079454906 99.311357293691 a6085 PTEN_mut 275 I-BET BRD2, BRD3, BRD4 9 40 2.99573227355399 NA 3.77506548274185 4.09831306406452 -0.323247581322663 1.58307593403153 1.31380181766215 0.237089906040434 0.204189561835778 0.246039834149315 0.523581879023026 NA NA NA 0.580540378414884 99.311357293691 a6086 gain_cnaBRCA10_(MDM2,NUP107) 155 AP-24534 ABL 4 43 -0.669430653942629 NA 1.09540870403061 1.47791334760081 -0.382504643570205 1.25463547063486 1.12956172510877 0.336023341562063 0.304873130501128 0.33863102393397 0.523607359320144 NA NA NA 0.592669975293738 99.311357293691 a6087 gain_cnaBRCA9_(KRAS) 1072 BMS-708163 g-secretase 4 42 1.6094379124341 NA 3.39006224985202 3.71226762786985 -0.322205378017833 0.703799578238418 0.974015059593481 0.336325860668322 0.457808427257516 0.330801228219521 0.523727576144037 NA NA NA 0.445211641033188 99.311357293691 a6088 gain_cnaBRCA12_(TERT) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 9 34 -1.38629436111989 0.693147180559945 -2.03837068684121 -2.26872480225473 0.230354115413518 1.17074849894874 0.895881435434215 0.241021298089087 0.196757984845048 0.257125671213257 0.523831773211678 NA NA NA 0.594210801357153 99.311357293691 a6089 loss_cnaBRCA24 1067 CCT007093 PPM1D 3 43 1.88706964903238 NA 4.44024897719224 4.0608957992584 0.379353177933835 1.01824280751658 0.987416002302056 0.383635288364579 0.372556697806733 0.384187796277773 0.523919276004021 NA NA NA 0.588952729891185 99.311357293691 a6090 ARID1A_mut 1024 CEP-701 FLT3, JAK2, NTRK1, RET 5 40 0.693147180559945 NA 0.235423171164657 0.674337141254586 -0.438913970089929 1.21491936623917 1.46164300924359 0.304700699098259 0.361270041688942 0.300288078083492 0.524046203143889 NA NA NA 0.487466465915012 99.311357293691 a6091 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 208 SB-715992 KIF11 9 40 -2.05572501506252 NA -0.908701670535819 -1.31441874649906 0.405717075963242 1.34541159446833 1.77931544736399 0.236813056616837 0.301556101962663 0.228018632988491 0.524064767412924 NA NA NA 0.455311569363874 99.311357293691 a6092 gain_cnaBRCA30_(CRNKL1,FOXA2) 301 PHA-793887 CDK-pan 5 43 2.32630161961136 NA 3.36974778801827 2.87023759430106 0.499510193717215 1.26746082855712 1.67849979559881 0.303315264932904 0.394103062171838 0.297593240718277 0.524099926389854 NA NA NA 0.453667463674478 99.311357293691 a6093 POLR2B_mut 1239 YK 4-279 RNA helicase A 3 39 2.30258509299405 NA 2.47802050224477 1.97782460152664 0.500195900718131 1.83614476058845 1.26461811908299 0.38500907245955 0.272416375579138 0.395531183026886 0.524151533053038 NA NA NA 0.685781569819206 99.311357293691 a6094 gain_cnaBRCA47_(EGFR) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 7 38 0.693147180559945 NA 0.304270547595617 0.684755465074669 -0.380484917479052 0.660135223163325 1.52996656176709 0.264137691728169 0.576374209598744 0.248688387698878 0.524157696799063 NA NA NA 0.292192624832875 99.311357293691 a6095 gain_cnaBRCA14_(RAD21) 140 Vinorelbine Microtubules 21 26 -2.74887219562247 NA -3.42776530976256 -3.73878203593231 0.311016726169754 1.56051791490181 1.72079627236327 0.18832572523887 0.199303528142657 0.180740004592534 0.52420452500814 NA NA NA 0.519862799654591 99.311357293691 a6096 gain_cnaBRCA30_(CRNKL1,FOXA2) 281 CH5424802 ALK 5 43 1.63315443905142 NA 3.86536655329026 3.54150393683302 0.323862616457245 1.11884981942229 1.06334699829453 0.303160452945859 0.289460310789941 0.304569079497734 0.524310793234352 NA NA NA 0.565657355229145 99.311357293691 a6097 gain_cnaBRCA12_(TERT) 1052 RO-3306 CDK1 9 34 1.6094379124341 NA 3.75509433356307 3.46494427958787 0.290150053975194 1.10485933673805 1.22854034079523 0.240707648815319 0.262612664189292 0.236174624748082 0.524369405252279 NA NA NA 0.505448883695768 99.311357293691 a6098 loss_cnaBRCA60 269 NSC-207895 MDM4 3 46 2.99573227355399 NA 4.17671219033851 4.63180523922258 -0.455093048884071 0.369591522631172 1.21526022504457 0.381929125290266 1.23134060447113 0.374481974728812 0.524668196868011 NA NA NA 0.156223730299342 99.311357293691 a6099 gain_cnaBRCA47_(EGFR) 256 JW-7-24-1 LCK 7 41 2.32630161961136 NA 1.57617740203329 1.88219698440174 -0.306019582368457 0.665792376754412 1.22510298022548 0.262127435855196 0.459632151182376 0.249790905179362 0.524727500393456 NA NA NA 0.349189124535147 99.311357293691 a6100 loss_cnaBRCA23 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 3 42 -0.669430653942629 NA -4.35863307205492 -3.42387423437915 -0.934758837675769 0.689963741759512 2.49326475815487 0.383233807702654 1.3547941451126 0.374913588546262 0.524748961591614 NA NA NA 0.134287185865279 99.311357293691 a6101 loss_cnaBRCA29_(MAP2K4) 194 AUY922 HSP90 6 41 -1.36257783450257 NA -2.81731349732084 -2.33176174468978 -0.485551752631057 1.15798908017113 1.79202334512798 0.28016890976104 0.419305985648242 0.270951689302005 0.524792424118647 NA NA NA 0.399833400252304 99.311357293691 a6102 gain_cnaBRCA47_(EGFR) 204 Tipifarnib Farnesyl-transferase (FNTA) 7 41 2.77258872223978 NA 1.28000008038925 1.67802128676436 -0.39802120637511 0.973780016976096 1.5844417447125 0.262066588339631 0.408738318137905 0.251205957999631 0.524823311982871 NA NA NA 0.386744607590889 99.311357293691 a6103 gain_cnaBRCA14_(RAD21) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 21 26 2.77258872223978 NA 5.11779931669976 4.92456092486112 0.193238391838646 1.0203966457798 1.03411547832396 0.187967625257869 0.189375761511811 0.186863455667289 0.524990142707571 NA NA NA 0.524527733191577 99.311357293691 a6104 gain_cnaBRCA15 1199 Tamoxifen ER 22 25 1.6094379124341 NA 3.96441565656904 3.78535424013072 0.179061416438317 0.954380459492046 0.957693334392012 0.187273596904299 0.187620581139747 0.186971559692428 0.525010545649844 NA NA NA 0.524969739546129 99.311357293691 a6105 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1377 Afatinib (rescreen) ERBB2, EGFR 6 41 2.30258509299405 NA 2.34747225966637 2.90593298907631 -0.558460729409938 2.78012143212313 1.87321213121797 0.280007434226188 0.200876380059217 0.298129998254295 0.525030284729349 NA NA NA 0.651501313348809 99.311357293691 a6106 gain_cnaBRCA19 201 Epothilone B Microtubules 4 44 -3.44201937618241 NA -4.79076242881818 -4.18530296985988 -0.605459458958305 1.49601073215202 1.83008668034719 0.334474824088779 0.404715986286641 0.330836492861334 0.525044521871492 NA NA NA 0.491257833339901 99.311357293691 a6107 gain_cnaBRCA14_(RAD21) 1023 GW 441756 NTRK1 20 25 0.693147180559945 NA 2.49876896682871 2.24770105014752 0.251067916681189 1.31517124624747 1.29872088599781 0.192239658893048 0.190901312203678 0.193319380159419 0.525053945427516 NA NA NA 0.525840889975472 99.311357293691 a6108 loss_cnaBRCA33 229 LY317615 PRKCB (PKCbeta) 6 43 2.99573227355399 2.32630161961136 3.75482280167569 3.30329380740052 0.451528994275171 1.34882863180523 1.64802958950838 0.278922976957527 0.334756383152143 0.273981120939622 0.525265037472824 NA NA NA 0.479135762921729 99.311357293691 a6109 ASH1L_mut 279 BIX02189 MAP2K5 (MEK5) 3 46 2.99573227355399 NA 4.70422341675632 5.04842991157495 -0.344206494818639 0.795074209888876 0.907252651774817 0.38128108191226 0.43292373282583 0.379394311105384 0.525368875580427 NA NA NA 0.536371369246178 99.311357293691 a6110 gain_cnaBRCA8_(CHD4,WNK1) 1262 UNC1215 LMBL3 3 43 0 NA 2.54458159235632 2.77237649943801 -0.227794907081691 0.599937192568061 0.595745410668754 0.382246890839269 0.379697924888777 0.382369554179159 0.525415502348724 NA NA NA 0.582571613862256 99.311357293691 a6111 loss_cnaBRCA34 1006 Cytarabine DNA synthesis 5 40 0.693147180559945 NA 1.62245609242398 1.15679292259022 0.465663169833755 1.64155682949117 1.52201835616685 0.303654158507805 0.283671671591227 0.305951086560159 0.525465727621115 NA NA NA 0.573479576154416 99.311357293691 a6112 BRCA2_mut 1502 Bicalutamide ANDR (androgen receptor) 5 40 2.30258509299405 NA 4.4003098231871 4.57805229666918 -0.17774247348208 0.539647912721696 0.58995277481382 0.303596834400878 0.329367480707266 0.301282545095533 0.525543540648211 NA NA NA 0.521154444202564 99.311357293691 a6113 loss_cnaBRCA57 167 OSU-03012 PDPK1 (PDK1) 5 43 2.77258872223978 NA 2.56958413599241 2.21058308474616 0.359001051246258 0.451728715165242 1.23520552885286 0.30224720718979 0.794727098796311 0.290640741852624 0.525555623299807 NA NA NA 0.216203075401426 99.311357293691 a6114 gain_cnaBRCA31 207 AS601245 JNK 16 32 2.07944154167984 NA 2.43416093968749 2.182220599882 0.251940339805492 1.62389427998405 1.08799237963397 0.195683290429135 0.155145776982456 0.231564434201506 0.525928386434175 NA NA NA 0.580593461770689 99.311357293691 a6115 gain_cnaBRCA15 310 YM201636 FYV1 22 27 1.63315443905142 NA 2.311503907547 2.49872669407921 -0.18722278653221 1.0518107740827 0.993814006286015 0.183527456236697 0.178000445655722 0.188388154471561 0.525929407033314 NA NA NA 0.528575065712419 99.311357293691 a6116 gain_cnaBRCA13_(FGFR1,WHSC1L1) 175 PAC-1 CASP3 agonist 10 38 0.940007258491471 NA 2.62178240762868 2.34338164078533 0.278400766843354 1.22879712125626 1.22593776596026 0.226988407831439 0.226563654835659 0.227092087847777 0.526206542483524 NA NA NA 0.533839184404137 99.311357293691 a6117 PTEN_mut 345 KIN001-270 CDK9 9 40 2.99573227355399 NA 4.9744689339811 5.13753855037065 -0.16306961638955 0.756421449824043 0.678563455947878 0.235501900708583 0.215580370476648 0.240315942392978 0.526354918284811 NA NA NA 0.563724736005465 99.311357293691 a6118 PIK3CA_mut 1262 UNC1215 LMBL3 16 30 0 NA 2.83436119836581 2.71653850263502 0.117822695730787 0.693666847885667 0.538491963576207 0.197705938666608 0.16985487498778 0.21880121468909 0.52636265392449 NA NA NA 0.559826376704531 99.311357293691 a6119 NF1_mut 1036 PLX4720 BRAF 4 39 2.30258509299405 NA 4.22953374372562 4.63426510854097 -0.404731364815343 1.30692251190571 1.19824840594574 0.335450135356412 0.309682755579119 0.337769166065279 0.526419414324589 NA NA NA 0.588223540751058 99.311357293691 a6120 NF1_mut 341 EX-527 SIRT1 5 44 2.99573227355399 NA 5.81932370066724 5.62157477721548 0.197748923451763 0.468591980065798 0.671396639931678 0.301180248834304 0.422006632345683 0.294533680525845 0.526457168189475 NA NA NA 0.427806168404266 99.311357293691 a6121 gain_cnaBRCA8_(CHD4,WNK1) 1032 Afatinib ERBB2, EGFR 3 42 -0.693147180559945 NA 0.945166603136015 0.243707776627934 0.70145882650808 0.994091780046038 1.86942830357161 0.3816461373727 0.705627830938904 0.375226386145924 0.526459721281997 NA NA NA 0.351708954042568 99.311357293691 a6122 gain_cnaBRCA13_(FGFR1,WHSC1L1) 190 Bleomycin DNA damage 10 38 4.15888308335967 NA 2.57252381279836 1.94836635199549 0.624157460802872 2.7001265864682 2.76471178460338 0.226785349094081 0.231158592315954 0.225758599604773 0.526575055527933 NA NA NA 0.527730359827765 99.311357293691 a6123 gain_cnaBRCA16 165 DMOG Prolyl-4-Hydroxylase 16 30 8.29404964010203 NA 7.7681704336734 7.46427932145788 0.303891112215521 2.04156713802011 1.20131059017422 0.197312215176956 0.148851882730749 0.252966314208092 0.527182855558092 NA NA NA 0.590206432966741 99.311357293691 a6124 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 275 I-BET BRD2, BRD3, BRD4 7 42 2.99573227355399 NA 3.73505091166189 4.08958941727676 -0.354538505614869 1.93808160275724 1.2575866929584 0.260020546220148 0.18293270268418 0.281919733724948 0.527268745555214 NA NA NA 0.654371991833365 99.311357293691 a6125 NF1_mut 1161 ZG-10 IRAK1 3 23 2.30258509299405 NA 2.46611947271326 1.91140509129153 0.554714381421729 1.64075343451367 1.38748268517612 0.393323277864344 0.338085156339259 0.399799137926768 0.527757488953596 NA NA NA 0.623578894633581 99.311357293691 a6126 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 208 SB-715992 KIF11 15 34 -2.05572501506252 NA -1.47428229452082 -1.13649501402861 -0.337787280492212 1.77524916008242 1.68643678943504 0.197147543598965 0.19027598383797 0.200296437203182 0.527841328087402 NA NA NA 0.538631907787419 99.311357293691 a6127 loss_cnaBRCA22_(SYNCRIP,ZNF292) 271 VNLG/124 HDAC, RAR 19 30 1.63315443905142 NA 4.2445699023546 4.09245790103887 0.152112001315734 1.001699784002 0.675011330202249 0.186472610100753 0.151853882515593 0.225347330496153 0.527864018889137 NA NA NA 0.564278629451128 99.311357293691 a6128 ASH1L_mut 166 FTI-277 Farnesyl transferase (FNTA) 3 44 0.0237165266173161 NA 1.95382514079678 2.26419901444681 -0.310373873650031 0.315177178216988 0.833737235241444 0.379567857929752 0.984759986131832 0.372268216568436 0.527931500513257 NA NA NA 0.228157867110673 99.311357293691 a6129 loss_cnaBRCA20 177 GSK-650394 SGK3 3 44 2.77258872223978 NA 4.61898529812406 3.97321973258193 0.645765565542123 0.967904844200821 1.72800379032917 0.379538941247242 0.667178772181183 0.373706104787601 0.527962797751577 NA NA NA 0.372877757630741 99.311357293691 a6130 gain_cnaBRCA48 262 VX-11e ERK 5 44 1.63315443905142 NA 4.13639403588221 3.73595034332176 0.400443692560452 1.11972350885129 1.35306525976401 0.30000379683111 0.357627297627486 0.295952977634126 0.528066840575756 NA NA NA 0.489744067830723 99.311357293691 a6131 loss_cnaBRCA36_(FAT1,IRF2) 196 Phenformin AAPK1 (AMPK) agonist 8 40 8.29404964010203 NA 7.57490429158253 7.12743484254403 0.447469449038493 1.60754106975449 1.85249692658628 0.246220550755892 0.278356464700982 0.24154936109021 0.528097079362461 NA NA NA 0.498467841727664 99.311357293691 a6132 loss_cnaBRCA57 1259 BMN-673 PARP1 5 41 2.30258509299405 NA 2.8863154713791 3.35666274404751 -0.470347272668412 1.28936264377559 1.5868599566901 0.301088226998622 0.364790522619076 0.296401248695864 0.528321815239499 NA NA NA 0.483911618262687 99.311357293691 a6133 NF1_mut 268 YM155 BIRC5 (Survivin) 5 44 1.63315443905142 NA -3.16399641957245 -3.64462136361367 0.480624944041221 1.56746112019139 1.60656806351982 0.299776619398434 0.306626389548046 0.299162516020779 0.528377972488424 NA NA NA 0.545503955777336 99.311357293691 a6134 CDH1_mut 202 GSK-1904529A IGF1R 4 44 0.0237165266173161 NA 1.93557236501516 2.21277461216515 -0.277202247149984 0.112966908404768 0.863656408935815 0.331773270160106 2.45383582736239 0.320963573339946 0.528382233684717 NA NA NA 0.0577742927412049 99.311357293691 a6135 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1052 RO-3306 CDK1 6 37 1.6094379124341 NA 3.81592111160411 3.47860615779542 0.337314953808688 1.46079259411954 1.1656553059354 0.27980811083015 0.230912283623669 0.289377959411427 0.528456986011231 NA NA NA 0.60937687177677 99.311357293691 a6136 loss_cnaBRCA7_(FAS,PTEN) 1009 ATRA Retinoic acid and retinoid X receptor agonist 4 41 2.30258509299405 NA 4.45814692861515 4.07161223187564 0.386534696739511 1.27894646638494 1.15201085611137 0.332841635350953 0.302228988389237 0.335530428978997 0.528528911286392 NA NA NA 0.596122485152069 99.311357293691 a6137 gain_cnaBRCA15 153 Midostaurin KIT 22 25 -0.669430653942629 NA 0.756409986606164 0.485265253140574 0.271144733465589 1.3908890887833 1.51844350091485 0.185676747020086 0.194943461453693 0.178567548481209 0.528534294563138 NA NA NA 0.526192703325998 99.311357293691 a6138 gain_cnaBRCA27_(CLTC,PPM1D) 1166 QL-VIII-58 MTOR, ATR 7 19 2.30258509299405 NA -1.2858238435123 -1.60494405297666 0.319120209464362 1.69025939903421 0.863848153916745 0.282737443578739 0.188799547363383 0.369417018508924 0.528572247582032 NA NA NA 0.647463676859229 99.311357293691 a6139 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 186 Bexarotene Retinioic acid X family agonist 14 33 2.07944154167984 NA 3.44176721344027 3.67340350716971 -0.231636293729436 1.48712048665125 0.970319333153696 0.202504444174117 0.155761618381738 0.23872171337304 0.528707526569528 NA NA NA 0.598307411492973 99.311357293691 a6140 loss_cnaBRCA24 177 GSK-650394 SGK3 3 44 2.77258872223978 NA 3.41111085336896 4.05557480836069 -0.644463954991736 0.636641151143288 1.73517405791622 0.378767082675407 1.01228761891122 0.371411704809417 0.52879856039768 NA NA NA 0.218911968124539 99.311357293691 a6141 gain_cnaBRCA14_(RAD21) 1059 AZD8055 MTORC1/2 19 24 0.693147180559945 NA 0.240524843415392 0.0432728967511037 0.197251946664288 0.850065189922873 1.12146854665036 0.19504309412843 0.232043317386264 0.17588718582741 0.528857262535194 NA NA NA 0.515545057621724 99.311357293691 a6142 loss_cnaBRCA38 1001 AICAR AAPK1 (AMPK) agonist 3 42 7.60090245954208 NA 7.24796727550852 7.77352015428481 -0.525552878776285 1.99062808350648 1.34904178692225 0.379327245830144 0.264013596075931 0.389574944135198 0.528963681743852 NA NA NA 0.694356766459143 99.311357293691 a6143 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1019 Bosutinib SRC, ABL, TEC 7 38 0.693147180559945 NA 2.45600480214549 2.70065527799818 -0.244650475852685 1.03331573393119 0.920782226726145 0.261017297923498 0.236762557482722 0.265698521052631 0.529047912483116 NA NA NA 0.574905942937696 99.311357293691 a6144 gain_cnaBRCA64_(SDHC) 177 GSK-650394 SGK3 8 39 2.77258872223978 NA 4.36199567561569 3.94314509546286 0.418850580152828 1.50593774900171 1.73511114522946 0.246166864606944 0.278132731867892 0.241396974081126 0.529131316828672 NA NA NA 0.499782349974696 99.311357293691 a6145 loss_cnaBRCA7_(FAS,PTEN) 163 JQ1 BRD4 4 43 0.940007258491471 NA -0.127746045013763 0.357187701756214 -0.484933746769977 1.64196142310382 1.44939812511081 0.331459778930678 0.295338087695935 0.334575944572099 0.529236909954944 NA NA NA 0.603496336568024 99.311357293691 a6146 gain_cnaBRCA61_(NOTCH2) 223 ZSTK474 PI3K 3 46 1.63315443905142 2.32630161961136 0.397406994302187 0.945920415704076 -0.548513421401888 0.458286354516121 1.48100618999565 0.377703396632705 1.19687923499497 0.370365380716942 0.529246023237529 NA NA NA 0.165062688990386 99.311357293691 a6147 gain_cnaBRCA19 203 BMS-345541 IKBKB 4 45 2.77258872223978 NA 3.22517994059226 3.55963456364587 -0.334454623053608 0.55656360329386 1.03513195139715 0.330693414449291 0.600927946193814 0.323103371123057 0.529273062867223 NA NA NA 0.340491590473128 99.311357293691 a6148 gain_cnaBRCA9_(KRAS) 154 CHIR-99021 GSK3B 4 43 0.940007258491471 NA 2.99985650730267 3.30107224083333 -0.301215733530658 1.09272723582507 0.894394397261582 0.331383591527925 0.275655006716496 0.336781775973672 0.529331163132207 NA NA NA 0.625894656286282 99.311357293691 a6149 loss_cnaBRCA33 1377 Afatinib (rescreen) ERBB2, EGFR 5 42 2.30258509299405 NA 3.36902939374389 2.7710223605097 0.598007033234194 1.02160156195027 2.06517102862994 0.29980668736329 0.585362293390171 0.28956780089585 0.529467334362437 NA NA NA 0.312086228534049 99.311357293691 a6150 gain_cnaBRCA12_(TERT) 156 AZD6482 PI3Kbeta 9 38 1.63315443905142 NA 1.77478387523974 2.11927646880003 -0.344492593560293 1.32264529000703 1.49594793792708 0.23488622373372 0.260457279183645 0.230283811907019 0.529543180575091 NA NA NA 0.505381988336294 99.311357293691 a6151 gain_cnaBRCA62 1069 EHT 1864 Rac GTPases 8 38 2.30258509299405 NA 3.38607420694792 3.59833695290264 -0.212262745954721 0.618762402731985 0.900266678101029 0.246342849812455 0.343044026297541 0.235777632470476 0.529826936938928 NA NA NA 0.433081066721566 99.311357293691 a6152 loss_cnaBRCA57 1017 Olaparib PARP1, PARP2 5 40 1.6094379124341 NA 4.31244752536718 4.04430441937412 0.268143105993065 0.909253623220836 0.890758291128307 0.300442152847212 0.294904632926538 0.301027909213636 0.529835164092999 NA NA NA 0.560478080467449 99.311357293691 a6153 gain_cnaBRCA61_(NOTCH2) 255 CP724714 ERBB2 3 45 2.32630161961136 NA 4.39516070444288 3.76356068393803 0.631600020504846 0.973292303435671 1.69896784905469 0.377306424605814 0.648931485716399 0.371755134069353 0.530022117751212 NA NA NA 0.383501788421579 99.311357293691 a6154 loss_cnaBRCA7_(FAS,PTEN) 1072 BMS-708163 g-secretase 4 42 1.6094379124341 NA 3.39457023417601 3.71183829602947 -0.317268061853459 1.02210931587907 0.953303996661037 0.331124897846397 0.310405214906579 0.332808907719569 0.530138396437686 NA NA NA 0.587045439206113 99.311357293691 a6155 gain_cnaBRCA30_(CRNKL1,FOXA2) 287 KIN001-244 PDPK1 (PDK1) 5 44 2.99573227355399 NA 3.73156497315501 3.44930389057334 0.282261082581669 0.563660307530872 0.97370405147969 0.298451009946937 0.50076451864798 0.289883853469369 0.530195387064403 NA NA NA 0.36503848535357 99.311357293691 a6156 gain_cnaBRCA31 292 Masitinib KIT 16 32 2.99573227355399 NA 3.86921740749404 4.08088236833857 -0.211664960844534 1.05715293721406 1.109995003083 0.19364713624819 0.200221702455218 0.190690012348377 0.530224891959502 NA NA NA 0.524861824334523 99.311357293691 a6157 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 197 Bryostatin 1 PRKC 9 39 -4.8283137373023 NA -2.62256757658457 -2.84932000305349 0.226752426468915 0.561579610137081 1.03514363744839 0.233875045756528 0.403776102935013 0.219054069663081 0.530233015428092 NA NA NA 0.374055392694774 99.311357293691 a6158 loss_cnaBRCA57 1219 PFI-1 BRD2, BRD3, BRD4 5 42 2.30258509299405 NA 3.44018461768109 3.14061159157458 0.299573026106504 0.634939190846707 1.03000637482326 0.299207453285403 0.471813727086237 0.290845798073734 0.530286950132956 NA NA NA 0.388597256425031 99.311357293691 a6159 loss_cnaBRCA34 224 AS605240 PI3Kgamma 5 44 2.99573227355399 2.32630161961136 3.69505968423914 3.22198368853803 0.47307599570111 0.709003058590511 1.64364326733339 0.29834007828461 0.667241121133636 0.287821576070225 0.530347623192506 NA NA NA 0.266907386227569 99.311357293691 a6160 gain_cnaBRCA58_(CCND1) 272 AR-42 HDAC 10 39 1.63315443905142 NA -0.131706178312151 0.212141645595721 -0.343847823907872 1.64046015799768 1.5088144143301 0.224020060450436 0.209604495562737 0.227892722022103 0.530445409850598 NA NA NA 0.558126190442788 99.311357293691 a6161 loss_cnaBRCA17 166 FTI-277 Farnesyl transferase (FNTA) 10 37 0.0237165266173161 NA 2.099345916236 2.28358845664027 -0.18424254040427 0.433310487100815 0.888229139445433 0.225304686431081 0.425197510535681 0.207426813895457 0.530485802784863 NA NA NA 0.364627811968935 99.311357293691 a6162 gain_cnaBRCA64_(SDHC) 170 Shikonin unknown 8 39 2.77258872223978 NA 0.245926910692387 -0.0460984346496582 0.292025345342046 1.12432903974462 1.20239908250815 0.245277609081955 0.259732991872535 0.242868902338893 0.53061385520186 NA NA NA 0.522667773468549 99.311357293691 a6163 loss_cnaBRCA18 11 Paclitaxel Microtubules 5 7 -2.27886856637673 NA -2.69255864538934 -3.38109394140272 0.688535296013375 1.25079768891625 2.10316272336094 0.380193115354187 0.550476949321798 0.327380895622316 0.530772097989842 NA NA NA 0.495211859339744 99.311357293691 a6164 gain_cnaBRCA13_(FGFR1,WHSC1L1) 166 FTI-277 Farnesyl transferase (FNTA) 10 37 0.0237165266173161 NA 2.38929494025426 2.20522385555425 0.184071084700017 0.946719996129476 0.782198581072422 0.225093159072019 0.194430333628279 0.235325260303654 0.530870143073541 NA NA NA 0.58210015198497 99.311357293691 a6165 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 302 PI-103 PI3Ka, PRKDC (DNAPK) 9 39 2.32630161961136 NA 0.775560780950616 1.20986524674031 -0.43430446578969 1.15860436665081 1.97619606492089 0.23349655046007 0.37485139732827 0.219767903346714 0.530895929939883 NA NA NA 0.394498601030706 99.311357293691 a6166 MLL3_mut 1133 JNJ-26854165 MDM2 3 40 2.30258509299405 NA 3.27690222040818 2.94570929788059 0.331192922527592 1.04447689497298 0.865955241786113 0.378286333228098 0.317089754806075 0.382459631336691 0.530933124298805 NA NA NA 0.641275792353437 99.311357293691 a6167 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 229 LY317615 PRKCB (PKCbeta) 9 40 2.99573227355399 2.32630161961136 3.05080591746441 3.42783293177742 -0.377027014313006 1.16587287764334 1.69708498700667 0.232873347193025 0.323386041088045 0.22216154005228 0.530961967104255 NA NA NA 0.435898593158769 99.311357293691 a6168 CDH1_mut 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 4 43 2.32630161961136 NA 0.952631346676858 1.46012743230085 -0.507496085623993 1.18161323147712 1.56011629922962 0.330017816385718 0.429494247444723 0.325293752699458 0.531022290520173 NA NA NA 0.469723300863844 99.311357293691 a6169 POLR2B_mut 1219 PFI-1 BRD2, BRD3, BRD4 3 44 2.30258509299405 NA 2.81937683311502 3.19655635079984 -0.377179517684814 0.246716991803985 1.02287469676849 0.376713258180307 1.52879424690976 0.368744596846923 0.531025811586955 NA NA NA 0.106432543079298 99.311357293691 a6170 loss_cnaBRCA28_(GPS2) 1043 JNK Inhibitor VIII JNK 3 40 2.30258509299405 NA 5.06063106765599 4.7775836896905 0.283047377965498 0.167504101450181 0.766710812962646 0.378056158540626 1.68979371558661 0.369170974479641 0.531181927866253 NA NA NA 0.0935046026631939 99.311357293691 a6171 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1032 Afatinib ERBB2, EGFR 6 39 -0.693147180559945 NA 0.731511136563996 0.222619477138393 0.508891659425604 1.73024451656979 1.85191247362032 0.276845564030713 0.294115458567949 0.274792500549859 0.53118286939443 NA NA NA 0.528114526582223 99.311357293691 a6172 loss_cnaBRCA18 1006 Cytarabine DNA synthesis 14 31 0.693147180559945 NA 1.42329062275485 1.11154608539229 0.311744537362566 1.24376670858105 1.64357251525652 0.203258821517103 0.250645507080842 0.189674951648794 0.531231089675137 NA NA NA 0.488106339858818 99.311357293691 a6173 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 119 Lapatinib ERBB2, EGFR 3 10 0.693147180559945 NA 0.695736705679699 1.66618025635467 -0.97044355067497 1.50045194310635 2.41989463692712 0.425546362924896 0.646767499041576 0.401027191790167 0.531243428507654 NA NA NA 0.435611063422039 99.311357293691 a6174 loss_cnaBRCA34 1175 AG-014699 PARP1, PARP2 3 40 1.6094379124341 NA 4.22375979856506 3.83440646230207 0.389353336262984 0.243065030961701 1.054842062255 0.377942397989544 1.6018484218914 0.369110552370883 0.531304918113578 NA NA NA 0.102758433495612 99.311357293691 a6175 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 306 TG101348 JAK2 6 42 2.32630161961136 NA 3.53497467520567 3.18059096829304 0.354383706912623 0.970033532855659 1.32081377691728 0.275287123566203 0.365331398255235 0.268307094539656 0.531317668220669 NA NA NA 0.44936977795275 99.311357293691 a6176 gain_cnaBRCA64_(SDHC) 1241 CHIR-99021 GSK3B 9 37 2.30258509299405 NA 4.4165028600316 4.18648325713824 0.230019602893361 0.905188269387405 0.997050446221326 0.234477423355454 0.254112443424647 0.230700065142242 0.531384924300444 NA NA NA 0.514518237883692 99.311357293691 a6177 NF1_mut 302 PI-103 PI3Ka, PRKDC (DNAPK) 4 44 2.32630161961136 NA 0.566902242317718 1.17948142459447 -0.61257918227675 2.29607728061826 1.82571866414615 0.329339503134875 0.266793799776549 0.335527698931226 0.531398630689649 NA NA NA 0.636159748440464 99.311357293691 a6178 ARID1A_mut 154 CHIR-99021 GSK3B 5 42 0.940007258491471 NA 3.51760640613737 3.24660715129422 0.270999254843159 0.628999113477855 0.93183575445133 0.298125195418795 0.430842029879427 0.290822984145661 0.531768918415853 NA NA NA 0.422318510822954 99.311357293691 a6179 gain_cnaBRCA31 51 Dasatinib ABL, SRC, KIT, PDGFR 3 9 0.246860077931526 NA 2.33799675977426 1.84114846603623 0.49684829373803 1.50376001796597 1.04426878255962 0.431690147992466 0.330403979226739 0.475785834103169 0.531869183868233 NA NA NA 0.636167223395354 99.311357293691 a6180 TP53_mut 1026 17-AAG HSP90 34 9 0 NA -0.984889192462689 -0.561183712886684 -0.423705479576005 1.70381156707068 2.12141653827507 0.236317559785877 0.248680950267565 0.199727621582757 0.531925194358812 NA NA NA 0.590928294668522 99.311357293691 a6181 ARID1A_mut 202 GSK-1904529A IGF1R 5 43 0.0237165266173161 NA 2.41242315070189 2.16377341027483 0.248649740427062 0.557605473916627 0.857365990899053 0.297577489453369 0.445924138227237 0.290015866113749 0.53194515650357 NA NA NA 0.40886638975603 99.311357293691 a6182 gain_cnaBRCA62 166 FTI-277 Farnesyl transferase (FNTA) 9 38 0.0237165266173161 NA 2.39877670217602 2.20782215101225 0.190954551163772 1.04655307268752 0.759298559222554 0.233505240009553 0.182460456279972 0.251488098909723 0.531955753024871 NA NA NA 0.616875075017033 99.311357293691 a6183 loss_cnaBRCA33 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 37 1.38629436111989 0.693147180559945 3.15604642381245 3.4709140285575 -0.314867604745046 0.544256423111305 1.08981873022329 0.300411741680051 0.578528045558137 0.288917409852676 0.531959955356894 NA NA NA 0.324076560918481 99.311357293691 a6184 NF1_mut 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 3 23 2.30258509299405 NA 3.11818501741029 2.63589359418589 0.482291423224403 0.528901555080753 1.28455946363429 0.389160308967774 0.911873709939775 0.375452781189202 0.532099001001983 NA NA NA 0.280375340553516 99.311357293691 a6185 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 16 26 1.38629436111989 0.693147180559945 3.56332558798262 3.35349391415261 0.209831673830007 1.10853088964966 1.0101528495079 0.200196751848764 0.189288071076055 0.207722696552535 0.532240996522518 NA NA NA 0.54262972873922 99.311357293691 a6186 loss_cnaBRCA38 1175 AG-014699 PARP1, PARP2 3 40 1.6094379124341 NA 4.2228750025974 3.83447282199965 0.388402180597753 0.242777607883647 1.05487054771958 0.377010174786396 1.59982703505299 0.368198905010101 0.53231333888684 NA NA NA 0.103287905079486 99.311357293691 a6187 loss_cnaBRCA24 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 3 42 -0.669430653942629 NA -4.34273495267917 -3.42500981433456 -0.917725138344618 0.664914873866799 2.49402879435342 0.376185351022678 1.38021448220523 0.367968942629044 0.532366311023927 NA NA NA 0.131489283673491 99.311357293691 a6188 loss_cnaBRCA28_(GPS2) 224 AS605240 PI3Kgamma 4 45 2.99573227355399 2.32630161961136 3.74813684997641 3.22777851815474 0.52035833182167 0.761824425583357 1.62681349123759 0.328144069814501 0.683042331470552 0.319863545897821 0.53243946232879 NA NA NA 0.294011313589545 99.311357293691 a6189 BRCA2_mut 1047 Nutlin-3a MDM2 5 38 2.07944154167984 1.38629436111989 3.93992629630284 4.24207855118433 -0.302152254881485 1.21052922927569 0.984559181674216 0.299505922177202 0.249603435897433 0.306890901537969 0.532465035555682 NA NA NA 0.616659746876657 99.311357293691 a6190 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 17 28 2.30258509299405 NA 1.49847290861608 1.28448361583617 0.213989292779911 1.12212608465895 1.09657653158766 0.193453736817602 0.190699864930908 0.195143053508622 0.532560372946208 NA NA NA 0.535864526337003 99.311357293691 a6191 gain_cnaBRCA27_(CLTC,PPM1D) 330 XMD13-2 RIPK 9 39 2.32630161961136 NA 3.49040770839665 3.77423975261733 -0.283832044220686 1.53875968596971 1.14232140132742 0.232543980496773 0.184455082108431 0.248469514701258 0.532566226056264 NA NA NA 0.613421535460467 99.311357293691 a6192 loss_cnaBRCA33 63 BMS-509744 ITK 4 8 2.32630161961136 NA 3.8858426806839 3.45132668875841 0.434515991925493 0.909869600171011 1.16977434783036 0.395633120928953 0.47755853349076 0.371452829967944 0.532781698849018 NA NA NA 0.500449162280327 99.311357293691 a6193 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1026 17-AAG HSP90 6 37 0 NA -1.32335258126261 -0.82693974249016 -0.496412838772451 1.58857273819098 1.81956115514243 0.27686379108733 0.312489838732692 0.272820090366017 0.532783919818386 NA NA NA 0.508505590040312 99.311357293691 a6194 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 262 VX-11e ERK 9 40 1.63315443905142 NA 4.02942846282421 3.71997322800376 0.309455234820451 0.624360923675456 1.4379177563417 0.231814502918534 0.495635173640859 0.215210663791897 0.53282374621285 NA NA NA 0.323473811106523 99.311357293691 a6195 gain_cnaBRCA27_(CLTC,PPM1D) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 9 36 -0.669430653942629 NA -3.94334092466021 -3.37190413161519 -0.57143679304502 2.64462577045653 2.39025611840136 0.234234792739537 0.216074727633912 0.239069273223827 0.532989249005314 NA NA NA 0.566153164084314 99.311357293691 a6196 loss_cnaBRCA7_(FAS,PTEN) 304 SB52334 ALK5 4 45 2.99573227355399 NA 4.68613148443845 4.2677371045658 0.418394379872655 1.31314701263589 1.27501826009168 0.327513863866832 0.318619603019778 0.328147755187892 0.533223729395575 NA NA NA 0.577749769409005 99.311357293691 a6197 loss_cnaBRCA34 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 5 38 -1.38629436111989 0.693147180559945 -2.47304417783009 -2.18728312023898 -0.285761057591109 1.2774528828149 0.914454211218814 0.298927009062018 0.223695966743938 0.312493566200802 0.533253843613606 NA NA NA 0.650652699353543 99.311357293691 a6198 CDH1_mut 262 VX-11e ERK 4 45 1.63315443905142 NA 3.37533215090689 3.81249903737646 -0.437166886469573 0.782539263632596 1.36448215071237 0.327481010062053 0.558651695558657 0.320390329944101 0.533264631220741 NA NA NA 0.368669296743571 99.311357293691 a6199 gain_cnaBRCA47_(EGFR) 1494 SN-38 TOP1 7 41 -2.99573227355399 NA -3.6740343952975 -3.24057579778658 -0.433458597510923 1.25721796078028 1.74465532834043 0.25662517953725 0.344776014209898 0.24844941603637 0.533428712236847 NA NA NA 0.446381032483231 99.311357293691 a6200 gain_cnaBRCA58_(CCND1) 211 TL-2-105 CRAF 10 39 2.32630161961136 1.63315443905142 4.10078547157934 3.85800713778643 0.242778333792906 1.38069051369335 1.01140297725507 0.222359167718426 0.175838344208995 0.240041150018959 0.533485239090648 NA NA NA 0.611943047327467 99.311357293691 a6201 gain_cnaBRCA27_(CLTC,PPM1D) 222 BX-912 PDPK1 (PDK1) 9 40 2.32630161961136 NA 4.17026889756078 3.81932095338934 0.350947944171439 1.53742488301878 1.51234531325815 0.231397788904229 0.228269977966235 0.232055431451279 0.533557393455647 NA NA NA 0.546727399647851 99.311357293691 a6202 MLL3_mut 185 OSI-906 IGF1R 3 45 0.940007258491471 NA 2.49679648938113 2.91993614081104 -0.42313965142991 1.17927918768547 1.12942110359042 0.373919001382566 0.358812108149209 0.374651801781241 0.533706251834641 NA NA NA 0.601515204065917 99.311357293691 a6203 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 14 28 1.38629436111989 0.693147180559945 3.57701466068959 3.36163735450127 0.215377306188326 1.07763677132186 1.03367500566905 0.205480375931206 0.199860761919007 0.208360756530939 0.533733467034335 NA NA NA 0.541558289261889 99.311357293691 a6204 loss_cnaBRCA42 178 BAY 61-3606 SYK 3 45 2.07944154167984 NA 3.66067889831241 3.05809108321688 0.602587815095526 0.41780107994386 1.64566691651507 0.373848570891345 1.44228400552841 0.366166329922698 0.533782993062408 NA NA NA 0.118478598946996 99.311357293691 a6205 gain_cnaBRCA31 170 Shikonin unknown 16 31 2.77258872223978 NA 0.155186884074381 -0.0746262519673441 0.229813136041725 1.06411037597168 1.24915453006964 0.193011162129342 0.215967385744054 0.183974945060571 0.5338212623179 NA NA NA 0.513327385469533 99.311357293691 a6206 loss_cnaBRCA17 293 MP470 PDGFR 10 38 2.99573227355399 NA 3.82699838184106 3.45384485800569 0.373153523835366 1.49560230126267 1.71598099216471 0.222758767825124 0.249500501249784 0.217457842213411 0.533910550514036 NA NA NA 0.506341611731599 99.311357293691 a6207 loss_cnaBRCA60 170 Shikonin unknown 3 44 2.77258872223978 NA 0.420366043512521 -0.0248073135530712 0.445173357065592 0.408377296912101 1.21486719439763 0.373881628614569 1.09010309934397 0.36643787824588 0.534104593187135 NA NA NA 0.19549734177966 99.311357293691 a6208 CDH1_mut 1033 Vismodegib SMO 4 41 2.30258509299405 NA 4.99460117993836 4.73686465648613 0.257736523452236 1.05511065736208 0.761063484676634 0.328259857007632 0.24427440065539 0.338653119800833 0.534193797855175 NA NA NA 0.663348727900132 99.311357293691 a6209 gain_cnaBRCA19 200 LAQ824 HDAC 4 44 0.0237165266173161 NA -3.10882892555535 -2.64588909027859 -0.46293983527676 0.864584834528415 1.4460712396542 0.327062254263526 0.535447554466149 0.320136257870298 0.534229185283111 NA NA NA 0.385543564008487 99.311357293691 a6210 loss_cnaBRCA29_(MAP2K4) 292 Masitinib KIT 7 41 2.99573227355399 NA 3.77122810271845 4.05114920945634 -0.279921106737885 0.687005821940806 1.14166397373765 0.256071162167948 0.407450850921615 0.245186949204907 0.53430898679098 NA NA NA 0.390860591735533 99.311357293691 a6211 CDH1_mut 136 Mitomycin C DNA crosslinker 4 44 2.77258872223978 NA -0.578978755672349 -0.0938804248118032 -0.485098330860546 1.0397899335707 1.50961550479561 0.326992059774879 0.466534936720046 0.321338996134797 0.534316559760056 NA NA NA 0.438206966857582 99.311357293691 a6212 CDH1_mut 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 4 41 -0.669430653942629 NA -2.75683189110703 -3.55734852428441 0.800516633177378 1.62406688471712 2.49008817610237 0.328125742339501 0.492908660788816 0.321481239443654 0.534360093393621 NA NA NA 0.418775736594037 99.311357293691 a6213 NF1_mut 206 Ruxolitinib JAK1, JAK2, TYK2 5 44 1.65632149833295 0.0237165266173161 4.54414447458318 4.35050090434769 0.193643570235485 0.316987664712525 0.678506262806254 0.295392358976857 0.6108867687678 0.285396879661197 0.534401277770206 NA NA NA 0.296637592585668 99.311357293691 a6214 gain_cnaBRCA64_(SDHC) 201 Epothilone B Microtubules 8 40 -3.44201937618241 NA -3.86995781745906 -4.30891794623587 0.438960128776816 2.49971713788231 1.65676502544175 0.242447469966641 0.175603920189422 0.264950142015325 0.534411116704993 NA NA NA 0.646252312314048 99.311357293691 a6215 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1502 Bicalutamide ANDR (androgen receptor) 18 27 2.30258509299405 NA 4.62522103424993 4.51369119874829 0.111529835501636 0.749688716256549 0.446788230418247 0.190461702528559 0.148768192828808 0.249625724019701 0.534675223361865 NA NA NA 0.575389490054038 99.311357293691 a6216 gain_cnaBRCA62 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 8 37 2.30258509299405 NA 2.91462991841687 3.23356688304056 -0.318936964623691 2.1898101626861 1.05250249497191 0.244036136816578 0.145645942309662 0.303027276559762 0.534699383730757 NA NA NA 0.698571065733605 99.311357293691 a6217 ARID1A_mut 153 Midostaurin KIT 5 42 -0.669430653942629 NA 0.225952125277168 0.658164057320574 -0.432211932043406 1.76231948327278 1.42764262154444 0.295934114274679 0.245251746999216 0.302745186730159 0.534775859772466 NA NA NA 0.621624293104244 99.311357293691 a6218 NF1_mut 1192 GSK269962A ROCK1, ROCK2 5 41 1.6094379124341 NA 3.05591415376115 2.62063016059323 0.435283993167924 0.943151815042078 1.51128743196224 0.296363943378218 0.461520601694971 0.288021976469927 0.534784052223141 NA NA NA 0.398450622301512 99.311357293691 a6219 gain_cnaBRCA62 286 KIN001-236 TIE2 10 39 2.32630161961136 NA 4.40436003996934 4.57491013222689 -0.170550092257551 1.08447290547111 0.673707149365562 0.221629177670071 0.157265424887182 0.253151673420952 0.534824164178828 NA NA NA 0.644624936364368 99.311357293691 a6220 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 293 MP470 PDGFR 5 43 2.99573227355399 NA 3.08856568368905 3.58309906986469 -0.494533386175644 2.29696586120019 1.60344859738088 0.295210132860071 0.215298535572159 0.308418609105044 0.535199850240844 NA NA NA 0.661505782837595 99.311357293691 a6221 gain_cnaBRCA31 287 KIN001-244 PDPK1 (PDK1) 16 33 2.99573227355399 NA 3.59926852435198 3.4193605957991 0.179907928552883 0.936579252710749 0.950170408336864 0.19020686495431 0.192090448333309 0.189342803116533 0.535400961632127 NA NA NA 0.535005535589771 99.311357293691 a6222 PTEN_mut 304 SB52334 ALK5 9 40 2.99573227355399 NA 4.06169085331864 4.35593694908368 -0.294246095765038 1.51952957670019 1.2219971500895 0.230321710298879 0.193642888086471 0.240791147298083 0.535454321473017 NA NA NA 0.598665050420701 99.311357293691 a6223 TP53_mut 1377 Afatinib (rescreen) ERBB2, EGFR 37 10 2.30258509299405 NA 2.74017414553219 3.1841642725436 -0.443990127011415 1.9275093303411 2.24430973356183 0.22256279384604 0.230343957366393 0.197829256974607 0.535479054373258 NA NA NA 0.57771704124529 99.311357293691 a6224 gain_cnaBRCA15 155 AP-24534 ABL 22 25 -0.669430653942629 NA 1.55585992808863 1.3481196138003 0.207740314288333 1.09469760255588 1.17571488881218 0.182448495599655 0.189769589157137 0.176692764772429 0.535695872840306 NA NA NA 0.533815527666192 99.311357293691 a6225 loss_cnaBRCA29_(MAP2K4) 134 Etoposide TOP2 7 40 2.77258872223978 NA 2.00603654112699 2.55953809918039 -0.5535015580534 2.648623729358 2.08240532377874 0.25548565366677 0.208977044160049 0.265799146656528 0.536047521371317 NA NA NA 0.614885860308608 99.311357293691 a6226 TP53_mut 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 34 9 -1.38629436111989 0.693147180559945 -2.26731146874525 -2.04370994676592 -0.22360152197933 0.863893857674064 1.26711442777249 0.23388790100577 0.258829855071955 0.176465137700632 0.536131342594585 NA NA NA 0.628140995175148 99.311357293691 a6227 loss_cnaBRCA22_(SYNCRIP,ZNF292) 224 AS605240 PI3Kgamma 19 30 2.99573227355399 2.32630161961136 3.44764293093092 3.15791216763939 0.289730763291538 1.21847692408023 1.77610519437225 0.182693564347702 0.237781083552518 0.163127028854809 0.536226289791606 NA NA NA 0.501914616787098 99.311357293691 a6228 gain_cnaBRCA12_(TERT) 1268 XAV 939 TNKS1 (tankyrase-1) 10 37 1.6094379124341 NA 3.49661822575795 3.7059898371216 -0.209371611363648 0.924328546618573 0.946974295836417 0.222147614613729 0.226512112094322 0.221095347871845 0.536237264647814 NA NA NA 0.537063946263137 99.311357293691 a6229 gain_cnaBRCA58_(CCND1) 200 LAQ824 HDAC 9 39 0.0237165266173161 NA -2.41943980162222 -2.7456276271764 0.326187825554181 0.944850273359404 1.49584167628838 0.230438637568808 0.345227000246742 0.218063068254354 0.536267588577984 NA NA NA 0.420169026560877 99.311357293691 a6230 gain_cnaBRCA64_(SDHC) 1502 Bicalutamide ANDR (androgen receptor) 8 37 2.30258509299405 NA 4.67534920038252 4.53299587512547 0.142353325257044 1.03823848441367 0.447218180726419 0.243090970608736 0.137110430208563 0.318308448520181 0.536275722115132 NA NA NA 0.714202124698204 99.311357293691 a6231 gain_cnaBRCA27_(CLTC,PPM1D) 1013 Nilotinib ABL 9 31 0.693147180559945 NA 3.37898229924673 3.15178885816135 0.227193441085381 0.817378413165519 0.996488027473266 0.23627655408942 0.277953806249314 0.227994150277411 0.536348298413827 NA NA NA 0.496080959533804 99.311357293691 a6232 gain_cnaBRCA63 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 37 1.38629436111989 0.693147180559945 3.70774052425671 3.39636077174071 0.311379752516002 1.44830021687897 0.993891934823694 0.297051502091128 0.214996689834801 0.313293368832133 0.536536030046315 NA NA NA 0.662688764587314 99.311357293691 a6233 ARID1A_mut 193 GW-2580 CSF1R (cFMS) 5 43 2.99573227355399 NA 5.66052717437049 5.4404658085927 0.220061365777794 0.682936478746263 0.75421169936665 0.294088258675652 0.322228161221939 0.291776653640604 0.536745841028851 NA NA NA 0.528908626297943 99.311357293691 a6234 loss_cnaBRCA17 86 A-443654 AKT1, AKT2, AKT3 3 9 0.0237165266173161 NA -1.68143528923027 -1.13969437515717 -0.541740914073103 1.21886830092918 1.28283922354622 0.426465973653546 0.44446222258805 0.422298370777547 0.536747349683311 NA NA NA 0.55001059720979 99.311357293691 a6235 gain_cnaBRCA8_(CHD4,WNK1) 333 T0901317 LXR 4 44 2.32630161961136 NA 4.5069017278344 4.75621206768382 -0.249310339849423 1.14421384297484 0.733539092543867 0.32502322739401 0.217887889908097 0.339873283351308 0.536770292293036 NA NA NA 0.69571065996702 99.311357293691 a6236 CDH1_mut 1133 JNJ-26854165 MDM2 4 39 2.30258509299405 NA 3.22855156556372 2.94217621318444 0.286375352379273 0.973669471041015 0.867416133356678 0.327051361613848 0.294119679107419 0.330147597406419 0.53677585039924 NA NA NA 0.605828444216171 99.311357293691 a6237 POLR2B_mut 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 3 46 1.63315443905142 NA 3.9257536234418 3.55388972045998 0.371863902981825 0.470444530801191 1.02051689290258 0.370651023872405 0.790452175835739 0.364387797564193 0.536932461071686 NA NA NA 0.307805205414691 99.311357293691 a6238 ASH1L_mut 206 Ruxolitinib JAK1, JAK2, TYK2 3 46 1.65632149833295 0.0237165266173161 4.14219019208629 4.38513459973816 -0.242944407651874 0.538290157460652 0.660311151492161 0.370578447696567 0.451326118980046 0.367924132589419 0.537011862616728 NA NA NA 0.521652418827035 99.311357293691 a6239 PTEN_mut 208 SB-715992 KIF11 9 40 -2.05572501506252 NA -1.56078339009233 -1.16770035959885 -0.393083030493485 1.57533280169339 1.74072186793119 0.229377055550205 0.249523802253685 0.225816104074487 0.537122460211765 NA NA NA 0.519080136935301 99.311357293691 a6240 loss_cnaBRCA34 200 LAQ824 HDAC 5 43 0.0237165266173161 NA -3.05694758328476 -2.64115576181525 -0.415791821469516 0.551656530096122 1.47159544735199 0.29373442805795 0.75371503605163 0.282544922395416 0.537233915592621 NA NA NA 0.235283696813974 99.311357293691 a6241 gain_cnaBRCA13_(FGFR1,WHSC1L1) 256 JW-7-24-1 LCK 11 37 2.32630161961136 NA 1.64554551842523 1.8946572289737 -0.249111710548466 0.791786739368736 1.25232290045965 0.213324407050048 0.314619705234106 0.198919711886632 0.537547697368837 NA NA NA 0.436455867539624 99.311357293691 a6242 gain_cnaBRCA47_(EGFR) 1166 QL-VIII-58 MTOR, ATR 3 23 2.30258509299405 NA -1.9024211341656 -1.46901915254982 -0.433401981615778 1.02278619655562 1.13826684463708 0.383849109937389 0.423746412569235 0.380756044733925 0.537665797473873 NA NA NA 0.549804546914277 99.311357293691 a6243 gain_cnaBRCA61_(NOTCH2) 254 AC220 FLT3 3 45 0.0237165266173161 NA 2.53132359448386 2.20325778404933 0.328065810434533 0.237919620055106 0.904752253137448 0.370171006548561 1.37889346981366 0.36260292173563 0.537798059846401 NA NA NA 0.129791984870184 99.311357293691 a6244 gain_cnaBRCA19 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 42 1.38629436111989 NA 3.29962563185618 2.81660768321786 0.483017948638328 0.667331412174902 1.52936661050488 0.32492398482202 0.723805203570626 0.315828752452541 0.53783532318562 NA NA NA 0.277897338051592 99.311357293691 a6245 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1268 XAV 939 TNKS1 (tankyrase-1) 8 39 1.6094379124341 NA 3.47303896087543 3.70008960369424 -0.22705064281881 0.815846016457706 0.964043920229916 0.240896760626646 0.2783008536398 0.235518982127557 0.537949151518331 NA NA NA 0.501557218701982 99.311357293691 a6246 gain_cnaBRCA64_(SDHC) 155 AP-24534 ABL 8 39 -0.669430653942629 NA 1.6729204101062 1.39868065338738 0.274239756718827 1.36935615971984 1.09088044671327 0.240839906257684 0.200269122661949 0.25139304453122 0.538044693313361 NA NA NA 0.607180563336743 99.311357293691 a6247 CDH1_mut 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 4 45 3.68887945411394 NA 3.10310575928123 3.49113442640267 -0.388028667121449 1.20542577177923 1.19875075481342 0.323578893060147 0.321901751402505 0.323694200452742 0.538134247457309 NA NA NA 0.574451181493112 99.311357293691 a6248 gain_cnaBRCA64_(SDHC) 282 EKB-569 EGFR 8 39 0.916290731874155 2.99573227355399 1.15386663269034 1.66508300475208 -0.511216372061743 2.63321715980622 2.01521717935999 0.240776588757165 0.194141364360303 0.253678053808622 0.538151106537137 NA NA NA 0.616729005224698 99.311357293691 a6249 NF1_mut 150 Bicalutamide ANDR (androgen receptor) 5 43 0.0237165266173161 NA 2.92671101451144 2.74350364216681 0.183207372344637 0.239680402351253 0.650497143301998 0.292861439333397 0.764381945905387 0.28164208595084 0.538439102342763 NA NA NA 0.231961282743727 99.311357293691 a6250 loss_cnaBRCA7_(FAS,PTEN) 219 AT-7519 CDK9 4 45 2.32630161961136 NA 1.13236934897182 1.71996771709025 -0.587598368118433 1.69021153157601 1.82652926509036 0.323187685957808 0.347647828180734 0.321702137134586 0.538623718868254 NA NA NA 0.547505201508842 99.311357293691 a6251 loss_cnaBRCA28_(GPS2) 201 Epothilone B Microtubules 4 44 -3.44201937618241 NA -3.69908151289545 -4.28454668948922 0.585465176593761 1.60151823825861 1.82440314491003 0.323335723099601 0.365568847489592 0.320907787419229 0.538878057892917 NA NA NA 0.529715709504903 99.311357293691 a6252 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 165 DMOG Prolyl-4-Hydroxylase 9 37 8.29404964010203 NA 7.28473972482104 7.63936348808437 -0.354623763263329 1.33562859788722 1.58248445727095 0.230193471951864 0.2655107593715 0.22409304662296 0.53887971868029 NA NA NA 0.502837140406949 99.311357293691 a6253 gain_cnaBRCA14_(RAD21) 265 Tubastatin A HDAC6 21 28 2.99573227355399 NA 4.58571327097582 4.77129416007259 -0.185580889096769 1.13647880971291 0.959495944250874 0.178700741126556 0.163294632078225 0.19341498023909 0.538880747951351 NA NA NA 0.549309080936225 99.311357293691 a6254 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1192 GSK269962A ROCK1, ROCK2 6 40 1.6094379124341 NA 3.01419778381403 2.6160055162561 0.398192267557926 1.62358238263631 1.44785219474209 0.271085506648117 0.245255351263025 0.275022732986124 0.538975758912208 NA NA NA 0.589940308317529 99.311357293691 a6255 POLR2B_mut 1199 Tamoxifen ER 3 44 1.6094379124341 NA 3.53848196219059 3.89171714911853 -0.353235186927937 0.220049134518808 0.977274920464138 0.369324208505538 1.60525597021944 0.361449147554277 0.539079289161669 NA NA NA 0.0990452963580994 99.311357293691 a6256 loss_cnaBRCA38 154 CHIR-99021 GSK3B 4 43 0.940007258491471 NA 3.5444994931956 3.25040777702934 0.29409171616626 0.115527248940237 0.940556764877368 0.323478568819132 2.54564805155531 0.312678327505947 0.539158381308224 NA NA NA 0.064143364676135 99.311357293691 a6257 loss_cnaBRCA29_(MAP2K4) 302 PI-103 PI3Ka, PRKDC (DNAPK) 7 41 2.32630161961136 NA 0.726576535997558 1.19704282681572 -0.470466290818163 0.725897690535003 1.97507308772316 0.252893967394282 0.648116527924781 0.238201965153862 0.539371796324112 NA NA NA 0.265319716472943 99.311357293691 a6258 loss_cnaBRCA20 288 KIN001-055 JAK3, MNK1 3 46 2.32630161961136 NA 4.63579490361484 4.31965125610416 0.316143647510679 0.173247154414466 0.876216807651497 0.368416086302865 1.82481293028546 0.360805276445257 0.539380373340381 NA NA NA 0.0756357364707521 99.311357293691 a6259 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1028 VX-702 p38 8 37 0.693147180559945 NA 3.29073326574796 3.45625806230363 -0.165524796555671 1.08109895543474 0.579052041875781 0.241190630720982 0.153107905362011 0.285854784346274 0.539452401019908 NA NA NA 0.685537279607858 99.311357293691 a6260 loss_cnaBRCA29_(MAP2K4) 260 NG-25 MAP3K7 (TAK1) 7 42 2.32630161961136 NA 2.92944792619915 3.25482598442135 -0.325378058222208 1.19495762067113 1.30279841443985 0.252322248163568 0.272292550458371 0.249753188686607 0.539518887753389 NA NA NA 0.527724441854343 99.311357293691 a6261 gain_cnaBRCA31 1069 EHT 1864 Rac GTPases 14 32 2.30258509299405 NA 3.44266987153061 3.61337561451422 -0.17070574298361 0.860443178085764 0.862424845071319 0.198071309395694 0.198392813530558 0.197936949473543 0.539674551052649 NA NA NA 0.541727477433825 99.311357293691 a6262 loss_cnaBRCA7_(FAS,PTEN) 211 TL-2-105 CRAF 4 45 2.32630161961136 1.63315443905142 4.23077768259433 3.87882271909082 0.351954963503504 0.827021298150654 1.10772612095492 0.322312857697844 0.425569407088462 0.317727420926121 0.539719121773482 NA NA NA 0.47322412007629 99.311357293691 a6263 ARID1A_mut 163 JQ1 BRD4 5 42 0.940007258491471 NA 0.69805996464986 0.270423504100306 0.427636460549554 1.14068707428167 1.49110081415955 0.292230214582923 0.374893754993105 0.286792453259164 0.539879010743066 NA NA NA 0.474851716231106 99.311357293691 a6264 gain_cnaBRCA19 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 3 40 0.693147180559945 NA 2.57830094831636 2.93317752440601 -0.354876576089656 0.887089419814769 0.963035569333876 0.369867159664651 0.40004600231142 0.368497890825695 0.540073418469535 NA NA NA 0.565429390506152 99.311357293691 a6265 gain_cnaBRCA48 1067 CCT007093 PPM1D 5 41 1.88706964903238 NA 3.8277342705676 4.11708768163049 -0.289353411062889 1.49383503813056 0.923681572674218 0.292516126263743 0.193698369416342 0.313260997753978 0.540077707453478 NA NA NA 0.69199654046218 99.311357293691 a6266 loss_cnaBRCA57 1175 AG-014699 PARP1, PARP2 3 40 1.6094379124341 NA 4.21608112130279 3.83498236309674 0.381098758206048 0.477733259973281 1.05093890278285 0.369854319763157 0.797722892953617 0.362626939774435 0.540087420253753 NA NA NA 0.307196875714138 99.311357293691 a6267 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 288 KIN001-055 JAK3, MNK1 15 34 2.32630161961136 NA 4.22511520805568 4.38925336384708 -0.164138155791391 0.53027005857728 0.96410594051012 0.191274441314325 0.309536910742755 0.170249086635171 0.540157687293056 NA NA NA 0.448547357114057 99.311357293691 a6268 gain_cnaBRCA58_(CCND1) 261 TL-1-85 MAP3K7 (TAK1) 10 39 2.32630161961136 NA 4.23650111980919 3.97052578546412 0.265975334345066 1.33465347571289 1.18618761001976 0.218725896781045 0.199284188132053 0.224227038032066 0.540166533457791 NA NA NA 0.575403430502955 99.311357293691 a6269 loss_cnaBRCA17 286 KIN001-236 TIE2 11 38 2.32630161961136 NA 4.66620003423078 4.50360250473694 0.162597529493842 0.614508952709073 0.806426729134272 0.211272159824487 0.264597494921803 0.201627157954444 0.540168481232663 NA NA NA 0.481326008133769 99.311357293691 a6270 MLL3_mut 279 BIX02189 MAP2K5 (MEK5) 3 46 2.99573227355399 NA 4.71564811595822 5.04768482249657 -0.332036706538352 0.616027574999912 0.913702060782136 0.367689255385591 0.538996499529099 0.363397129972681 0.540177708053299 NA NA NA 0.455434597196467 99.311357293691 a6271 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 281 CH5424802 ALK 7 41 1.63315443905142 NA 3.80555590287443 3.53591733488171 0.269638567992728 1.3056732953349 1.02838929458826 0.252318234338682 0.206513044998417 0.262195035879564 0.540291867397299 NA NA NA 0.618696014241931 99.311357293691 a6272 MACF1_mut 1028 VX-702 p38 3 42 0.693147180559945 NA 3.66307653371778 3.40995678166821 0.253119752049572 0.568908968256777 0.691512684681904 0.368820073329185 0.444921360310365 0.366037757016716 0.540387536959153 NA NA NA 0.527528439798476 99.311357293691 a6273 loss_cnaBRCA34 219 AT-7519 CDK9 5 44 2.32630161961136 NA 1.19682129540084 1.7259981406351 -0.529176845234257 1.20916416729999 1.86476766042356 0.29104462039776 0.437638543669291 0.283776288309322 0.540409542319602 NA NA NA 0.416564586405991 99.311357293691 a6274 CDH1_mut 1021 Axitinib PDGFR, KIT, VEGFR 4 41 0.693147180559945 NA 2.80824106098039 2.42860657278311 0.379634488197273 1.30355425404865 1.16445995560448 0.323176030060563 0.291230293651516 0.326017641371103 0.540516355458021 NA NA NA 0.608871236489949 99.311357293691 a6275 POLR2B_mut 273 CUDC-101 HDAC, EGFR 3 46 1.63315443905142 NA 0.516126277716811 -0.0620468670998053 0.578173144816617 1.54933212555924 1.5750320872388 0.367339648235253 0.373175728611399 0.36708658160115 0.540561444345545 NA NA NA 0.588498315298955 99.311357293691 a6276 ARID1A_mut 1016 Temsirolimus MTOR 5 39 -1.6094379124341 NA -2.14152719135754 -1.70086580113551 -0.440661390222031 0.618314016327505 1.56853476794252 0.292968235266108 0.712682194784056 0.280938235624868 0.540726467393021 NA NA NA 0.260229757584305 99.311357293691 a6277 gain_cnaBRCA8_(CHD4,WNK1) 1004 Vinblastine Microtubules 3 42 -2.30258509299405 NA -3.01282417126713 -3.4871843688205 0.474360197553377 0.704491825650639 1.30987568645862 0.368279759955477 0.67333669502166 0.362141386741713 0.540978425066571 NA NA NA 0.370789535167343 99.311357293691 a6278 gain_cnaBRCA61_(NOTCH2) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 3 45 0.246860077931526 2.32630161961136 0.306257470160382 -0.303032494131627 0.60928996429201 2.78675625891166 1.58893074357925 0.367243180315383 0.21863769475482 0.383459107172609 0.541005745342203 NA NA NA 0.742572189177244 99.311357293691 a6279 loss_cnaBRCA28_(GPS2) 288 KIN001-055 JAK3, MNK1 4 45 2.32630161961136 NA 4.08582258251468 4.36151227025727 -0.27568968774259 1.11156188584813 0.838079737280351 0.321262720044486 0.248020097893369 0.328954006974598 0.541035554315832 NA NA NA 0.658645235047634 99.311357293691 a6280 loss_cnaBRCA57 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 37 1.38629436111989 0.693147180559945 3.70470326291419 3.39677121246267 0.307932050451522 0.829456781716301 1.06990741204775 0.293731021862015 0.371245443089094 0.287811867628952 0.541078067505355 NA NA NA 0.481722988146554 99.311357293691 a6281 TP53_mut 1219 PFI-1 BRD2, BRD3, BRD4 37 10 2.30258509299405 NA 3.12571192424081 3.3455268737628 -0.219814949521989 0.838004195110903 1.48509616840084 0.219496586517997 0.262307695837846 0.148013949668113 0.541091769645746 NA NA NA 0.662381573372679 99.311357293691 a6282 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 279 BIX02189 MAP2K5 (MEK5) 9 40 2.99573227355399 NA 5.19478428033523 4.9896846914925 0.205099588842731 0.708012289020092 0.938062439979622 0.227117956313583 0.289683656658833 0.218641723729165 0.541122643705505 NA NA NA 0.473136338268616 99.311357293691 a6283 gain_cnaBRCA27_(CLTC,PPM1D) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 10 33 0.693147180559945 NA 2.74461707471991 2.95805554769668 -0.213438472976775 1.00273805069465 0.946975501077016 0.222449058447478 0.212855663379797 0.225389646019381 0.541139505515978 NA NA NA 0.559740859951655 99.311357293691 a6284 loss_cnaBRCA33 326 GSK690693 AKT 6 42 2.32630161961136 NA 2.48472478581568 3.00455731689419 -0.519832531078506 1.91242732617645 1.93936572342762 0.268445339082866 0.271818188311405 0.268042548550234 0.541529300023586 NA NA NA 0.555111660821892 99.311357293691 a6285 MLL3_mut 346 THZ-2-102-1 CDK7 3 45 0.916290731874155 2.99573227355399 -2.21308453807169 -1.27662917871927 -0.936455359352418 2.5995822023139 2.55128190375897 0.366748266503836 0.360233024567899 0.367052875643682 0.541548940041342 NA NA NA 0.600381328652822 99.311357293691 a6286 gain_cnaBRCA12_(TERT) 1001 AICAR AAPK1 (AMPK) agonist 10 35 7.60090245954208 NA 7.50067565194408 7.80642833677276 -0.305752684828678 1.16778910496411 1.43807831652862 0.220620669689976 0.261821833693228 0.212611984559183 0.541611601832297 NA NA NA 0.498218534184674 99.311357293691 a6287 TP53_mut 1059 AZD8055 MTORC1/2 34 9 0.693147180559945 NA 0.179277623826218 -0.0541019625747189 0.233379586400937 0.926785631635884 1.30451977638316 0.230697376095257 0.251816146511675 0.178900765343697 0.541680929752524 NA NA NA 0.624874719684192 99.311357293691 a6288 gain_cnaBRCA47_(EGFR) 330 XMD13-2 RIPK 7 41 2.32630161961136 NA 3.45883410084117 3.7657849029697 -0.306950802128529 0.874242971489221 1.26459802944895 0.251437975534287 0.351104683867982 0.242725984843012 0.541700162822808 NA NA NA 0.442346473846207 99.311357293691 a6289 loss_cnaBRCA60 225 Genentech Cpd 10 AURKA, AURKB 3 46 2.32630161961136 NA 2.46128045251859 3.05437538130292 -0.593094928784329 0.535688639702617 1.65096532830627 0.366281712825407 1.10716353647817 0.359241298781717 0.541723513250159 NA NA NA 0.190439574445229 99.311357293691 a6290 loss_cnaBRCA29_(MAP2K4) 286 KIN001-236 TIE2 7 42 2.32630161961136 NA 4.37460416585345 4.56768729513257 -0.193083129279127 1.12855357930325 0.701883344468884 0.250875507523992 0.171089022993781 0.275092906535961 0.541837376158775 NA NA NA 0.674463117446622 99.311357293691 a6291 PTEN_mut 1008 Methotrexate Dihydrofolate reductase (DHFR) 7 38 -1.6094379124341 NA 0.44912945143077 0.725667031320221 -0.276537579889451 1.04159710530106 1.1018542073827 0.252858502234672 0.265493806081116 0.250974746056765 0.541946846743477 NA NA NA 0.538968585048565 99.311357293691 a6292 ARID1A_mut 265 Tubastatin A HDAC6 5 44 2.99573227355399 NA 4.42141760492886 4.72248016245182 -0.30106255752296 0.985672542150951 1.04334982608234 0.289882979257427 0.305438717878837 0.28855380045772 0.542020731279441 NA NA NA 0.547988423773771 99.311357293691 a6293 CDH1_mut 301 PHA-793887 CDK-pan 4 44 2.32630161961136 NA 2.43788932292155 2.9663045046216 -0.528415181700052 0.703650627198183 1.6937877154445 0.320746571689506 0.75096242549248 0.311972496247195 0.542120330902842 NA NA NA 0.264335794144242 99.311357293691 a6294 ASH1L_mut 1067 CCT007093 PPM1D 3 43 1.88706964903238 NA 4.42469413999953 4.06198102045789 0.362713119541635 0.587278394592226 1.00437220800845 0.366659870922012 0.61761699882299 0.361134165849582 0.542366947280205 NA NA NA 0.403896528831288 99.311357293691 a6295 ARID1A_mut 231 FMK RSK 5 44 2.99573227355399 2.32630161961136 5.43441154007447 5.60682266978716 -0.172411129712694 0.41639840114892 0.609421679675404 0.28955480222303 0.414053294241717 0.282909413075894 0.542476358465552 NA NA NA 0.437406204803566 99.311357293691 a6296 loss_cnaBRCA36_(FAT1,IRF2) 133 Doxorubicin DNA intercalating 9 39 0.0237165266173161 NA -1.37017265305272 -0.952292444414226 -0.417880208638493 2.11595884043975 1.77836946809352 0.226919922848409 0.197489762396156 0.234979410148374 0.542483489602369 NA NA NA 0.593960828997902 99.311357293691 a6297 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1069 EHT 1864 Rac GTPases 8 38 2.30258509299405 NA 3.3914231212211 3.59721086568723 -0.20578774446613 0.447563936433683 0.919511126861484 0.238762882146831 0.459795188383375 0.223801255313281 0.542510082733403 NA NA NA 0.354393455205682 99.311357293691 a6298 gain_cnaBRCA9_(KRAS) 1004 Vinblastine Microtubules 4 41 -2.30258509299405 NA -3.0782693894363 -3.49236923040286 0.41409984096656 0.416999921759226 1.33062769294047 0.321483831914054 0.993045368496879 0.31120639015972 0.54262943786489 NA NA NA 0.186891965417371 99.311357293691 a6299 gain_cnaBRCA14_(RAD21) 326 GSK690693 AKT 21 27 2.32630161961136 NA 3.13396934709582 2.78838517538658 0.345584171709247 2.18350319787529 1.72256316645529 0.178458099860753 0.158270513203519 0.200622060449832 0.542667126901392 NA NA NA 0.555192005639406 99.311357293691 a6300 PIK3CA_mut 287 KIN001-244 PDPK1 (PDK1) 17 32 2.99573227355399 NA 3.59180879910277 3.41770145207047 0.174107347032302 1.03007569359149 0.899523287020651 0.184047463574252 0.169023837874725 0.19355513030571 0.542673374029554 NA NA NA 0.561120181334837 99.311357293691 a6301 gain_cnaBRCA47_(EGFR) 224 AS605240 PI3Kgamma 7 42 2.99573227355399 2.32630161961136 2.92989925083769 3.32698299907156 -0.39708374823387 0.290025551826212 1.69455395198168 0.250354178407309 1.3691336702354 0.234329363057165 0.542674093320176 NA NA NA 0.167950088357038 99.311357293691 a6302 gain_cnaBRCA31 163 JQ1 BRD4 16 31 0.940007258491471 NA 0.498179417569842 0.221845687559506 0.276333730010336 1.49818918019463 1.44575239408878 0.188824762815889 0.184445151295538 0.191134893596011 0.54269357461939 NA NA NA 0.548941692301193 99.311357293691 a6303 CDH1_mut 326 GSK690693 AKT 4 44 2.32630161961136 NA 2.37115322471575 2.99125325285425 -0.620100028138499 1.70467534914005 1.95165175897923 0.320216076524639 0.363764295912015 0.317730878618851 0.542785883666184 NA NA NA 0.531761747092341 99.311357293691 a6304 gain_cnaBRCA30_(CRNKL1,FOXA2) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 5 42 2.32630161961136 NA 1.01824414268574 1.46439962529084 -0.446155482605102 1.58137777694756 1.53388702435395 0.29005644404301 0.282130866582867 0.290865934401536 0.542885673498251 NA NA NA 0.576041664529168 99.311357293691 a6305 loss_cnaBRCA18 298 OSI-930 KIT, VEGFR, PDGFR 15 33 2.32630161961136 NA 4.02844222918507 3.86106050883184 0.167381720353229 0.831814971880185 0.895948736929554 0.190873161274985 0.201224702622134 0.186820644367279 0.542926518716302 NA NA NA 0.533216026297975 99.311357293691 a6306 gain_cnaBRCA58_(CCND1) 1149 TW 37 BCL2, BCL2L1 6 37 1.6094379124341 NA -0.433238499267809 -0.095218687125234 -0.338019812142575 0.563267190116587 1.31943137660798 0.270002665476975 0.600105630282868 0.256185973848494 0.542938587013965 NA NA NA 0.300721707821653 99.311357293691 a6307 gain_cnaBRCA16 288 KIN001-055 JAK3, MNK1 16 33 2.32630161961136 NA 4.23112019924753 4.39131573647501 -0.160195537227477 0.747274561067624 0.905499007155824 0.186669537137422 0.214373063895829 0.176914094837776 0.542986951062789 NA NA NA 0.516448151131934 99.311357293691 a6308 PIK3CA_mut 295 NVP-BHG712 EPHB4 17 32 2.32630161961136 NA 4.03480926361966 3.80802959004802 0.226779673571639 1.15472385273627 1.2717792639236 0.183898473029373 0.19639299303834 0.178316851048503 0.542998828504714 NA NA NA 0.531771645919682 99.311357293691 a6309 PTEN_mut 279 BIX02189 MAP2K5 (MEK5) 9 40 2.99573227355399 NA 4.86072017988913 5.06484911409287 -0.204128934203732 1.08327777812375 0.861479468528558 0.226034492550726 0.188436371839258 0.23695159508838 0.543046567562893 NA NA NA 0.607963357932034 99.311357293691 a6310 loss_cnaBRCA33 1243 piperlongumine Increases ROS levels 5 42 2.30258509299405 NA 1.48832267693108 1.73666675550555 -0.248344078574464 0.39354878183492 0.888961832773551 0.289915997750335 0.631037599497986 0.279364163250557 0.54308022872253 NA NA NA 0.291828218974245 99.311357293691 a6311 gain_cnaBRCA8_(CHD4,WNK1) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 3 43 0 NA 1.36046690068669 0.603871999705258 0.756594900981432 1.24326112618053 2.09833351234439 0.366007984648631 0.608556710291262 0.360569421653146 0.543081997038007 NA NA NA 0.409641349280873 99.311357293691 a6312 gain_cnaBRCA14_(RAD21) 1001 AICAR AAPK1 (AMPK) agonist 20 25 7.60090245954208 NA 7.88008578949865 7.62520130066059 0.254884488838059 1.46702901572635 1.31817244064872 0.183910067075031 0.173741954730092 0.193362022280349 0.543083184890827 NA NA NA 0.548285679068286 99.311357293691 a6313 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1022 AZD7762 CHEK1, CHEK2 8 37 0.693147180559945 NA 1.22478774043467 0.835553484577065 0.389234255857602 1.48120870920086 1.65596062062715 0.238971302430087 0.262781506373671 0.235050429949349 0.543174624599465 NA NA NA 0.522996329686762 99.311357293691 a6314 POLR2B_mut 178 BAY 61-3606 SYK 3 45 2.07944154167984 NA 2.54384902177058 3.13254640831967 -0.588697386549094 1.28688902163005 1.62540310327899 0.365159784671845 0.457457773478723 0.362185469783768 0.543294282622369 NA NA NA 0.517082382761947 99.311357293691 a6315 gain_cnaBRCA62 196 Phenformin AAPK1 (AMPK) agonist 10 38 8.29404964010203 NA 6.8888887562881 7.28441422293527 -0.39552546664717 2.81513059238727 1.47684011057255 0.217569322943423 0.140499864452739 0.267818746129417 0.543442542805581 NA NA NA 0.676701569556946 99.311357293691 a6316 gain_cnaBRCA15 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 22 25 2.77258872223978 NA 5.10875343664074 4.92479176363951 0.183961673001233 0.959083519094885 1.08551373404743 0.178872924553009 0.191809857367629 0.169469687237689 0.543686516481219 NA NA NA 0.540453436760402 99.311357293691 a6317 gain_cnaBRCA12_(TERT) 208 SB-715992 KIF11 9 40 -2.05572501506252 NA -1.55563029113256 -1.1688598068648 -0.386770484267761 1.87039313783726 1.68002582220281 0.225663910473535 0.206785662566633 0.23021698783215 0.543705422266821 NA NA NA 0.579569972687583 99.311357293691 a6318 gain_cnaBRCA47_(EGFR) 1067 CCT007093 PPM1D 7 39 1.88706964903238 NA 3.87499231120534 4.12344410567309 -0.248451794467757 1.5125256202298 0.878606191710476 0.251147668907088 0.164262866787016 0.282779471408082 0.543798216553876 NA NA NA 0.686144044189235 99.311357293691 a6319 gain_cnaBRCA19 1020 Lenalidomide TNFA 4 41 1.6094379124341 NA 4.04654556589669 4.27503691941951 -0.228491353522813 0.881267555014819 0.698706916627446 0.320481703719086 0.259275803611051 0.327020311500144 0.543882822227658 NA NA NA 0.645732517722067 99.311357293691 a6320 gain_cnaBRCA63 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 7 41 2.32630161961136 NA 5.10756668151477 4.93303835600735 0.174528325507417 0.91755973587434 0.659158112809802 0.249930825617409 0.190209224188668 0.264774599774632 0.544115785510907 NA NA NA 0.644020035352228 99.311357293691 a6321 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 255 CP724714 ERBB2 5 43 2.32630161961136 NA 3.37001778180876 3.85338660422085 -0.483368822412087 1.60904631746492 1.6805578329459 0.288671347891259 0.300407028166625 0.287624033482249 0.544243079236502 NA NA NA 0.554299454677207 99.311357293691 a6322 loss_cnaBRCA23 257 NPK76-II-72-1 PLK3 3 46 2.32630161961136 NA 4.02220863669388 3.44353105752767 0.578677579166213 0.667280909096473 1.61904880211473 0.363903476368996 0.867217346214456 0.357418243607216 0.544340531455748 NA NA NA 0.274006486350599 99.311357293691 a6323 gain_cnaBRCA15 1091 BMS-536924 IGF1R 22 25 1.38629436111989 NA 3.12763642765011 2.93148811575352 0.196148311896586 1.26055788133612 0.933721673170138 0.178573956875774 0.155604367558814 0.210071499390852 0.544357413144053 NA NA NA 0.552457368575745 99.311357293691 a6324 CDH1_mut 1050 ZM-447439 AURKB 4 35 1.38629436111989 0.693147180559945 3.27128052479619 2.84411191661769 0.427168608178496 1.76237061785289 1.27674871677606 0.322932012815924 0.242382960684467 0.334575318201334 0.544380661417262 NA NA NA 0.666575795570157 99.311357293691 a6325 gain_cnaBRCA8_(CHD4,WNK1) 1049 PD-173074 FGFR1, FGFR3 3 40 0.693147180559945 NA 3.32818468917733 2.90848243745336 0.419702251723971 0.739671565234105 1.16431948263971 0.365830934488925 0.567417042172137 0.360470006713652 0.544484137335679 NA NA NA 0.437425965620364 99.311357293691 a6326 gain_cnaBRCA16 1008 Methotrexate Dihydrofolate reductase (DHFR) 15 30 -1.6094379124341 NA 0.823472430811006 0.61223889626729 0.211233534543716 1.14227561299155 1.06947201505649 0.19313527147428 0.184923438915507 0.197511979341095 0.544581824604572 NA NA NA 0.555447671649828 99.311357293691 a6327 gain_cnaBRCA15 279 BIX02189 MAP2K5 (MEK5) 22 27 2.99573227355399 NA 4.94012695505696 5.0984315989431 -0.158304643886138 1.06945962438089 0.742018460587914 0.175287330257825 0.148023020483622 0.213343268792411 0.54460081709148 NA NA NA 0.559907953023299 99.311357293691 a6328 loss_cnaBRCA36_(FAT1,IRF2) 37 Crizotinib MET, ALK 3 11 0.693147180559945 NA 2.39953515879373 2.72122629775384 -0.321691138960112 0.786109848364521 0.79342748385191 0.406066692671977 0.409219067321675 0.405444915266075 0.544667436286953 NA NA NA 0.572354710910588 99.311357293691 a6329 loss_cnaBRCA60 1495 AZD-2281 PARP1, PARP2 3 42 2.30258509299405 NA 4.38484849308229 3.97110864008911 0.413739852993178 0.587160956822646 1.15421929803082 0.364802073317354 0.704644694415792 0.358458616745575 0.544789613264073 NA NA NA 0.353638233351256 99.311357293691 a6330 POLR2B_mut 1030 KU-55933 ATM 3 39 2.30258509299405 NA 3.90771483247365 4.24649816447668 -0.338783332003024 1.14372606401219 0.913135823247166 0.365844859534109 0.296210205103285 0.371010887294171 0.544910687843658 NA NA NA 0.662086034650283 99.311357293691 a6331 gain_cnaBRCA15 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 22 25 2.99573227355399 NA 3.71177858920095 3.96724007803444 -0.255461488833485 1.33554272133177 1.51268948729353 0.178301603014575 0.191279159216071 0.168879000600811 0.544968957234272 NA NA NA 0.541723601356941 99.311357293691 a6332 loss_cnaBRCA24 279 BIX02189 MAP2K5 (MEK5) 3 46 2.99573227355399 NA 4.71960636224823 5.04742667599939 -0.327820313751161 0.504689636238902 0.916826747631472 0.362983023841226 0.649548336665234 0.357559718450679 0.545355138381994 NA NA NA 0.383790641976787 99.311357293691 a6333 loss_cnaBRCA38 194 AUY922 HSP90 4 43 -1.36257783450257 NA -2.89890682986336 -2.34675546969192 -0.552151360171439 1.07340638146405 1.77160324537132 0.318458327926123 0.514391724985224 0.311667616106512 0.545448061466554 NA NA NA 0.402909784195526 99.311357293691 a6334 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 179 5-Fluorouracil DNA antimetabolite 7 42 3.46573590279973 NA 3.69549789018757 4.09913982103169 -0.403641930844114 1.06651732244521 1.69009153093052 0.248567170276361 0.378467299451528 0.238828444174192 0.54554722105835 NA NA NA 0.417249024343872 99.311357293691 a6335 TP53_mut 1019 Bosutinib SRC, ABL, TEC 35 10 0.693147180559945 NA 2.70811853499791 2.50327854540222 0.204839989595688 1.02115904609551 0.510983767197977 0.218464174906845 0.200595578503575 0.400873770841969 0.545553040669439 NA NA NA 0.393021817614756 99.311357293691 a6336 gain_cnaBRCA13_(FGFR1,WHSC1L1) 104 Bortezomib Proteasome 4 10 -3.91202300542815 NA -4.10131278376282 -4.76007516566137 0.658762381898549 1.69928528523348 1.81977912310024 0.367938155348395 0.387670267978597 0.362001285505605 0.545623758726279 NA NA NA 0.54476656607626 99.311357293691 a6337 gain_cnaBRCA8_(CHD4,WNK1) 275 I-BET BRD2, BRD3, BRD4 4 45 2.99573227355399 NA 3.64108777089977 4.07430579608129 -0.43321802518152 0.887606084213263 1.39055809971542 0.317606884504628 0.488074645821638 0.311542556380909 0.545631319981461 NA NA NA 0.4217934814441 99.311357293691 a6338 loss_cnaBRCA23 263 FR-180204 ERK 3 46 2.99573227355399 NA 5.60838252185026 5.34154808725143 0.266834434598831 0.738572878766264 0.735562305766815 0.362699225162108 0.361283824887477 0.362762518561441 0.545668162509445 NA NA NA 0.599423585100028 99.311357293691 a6339 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 221 TAK-715 p38a 7 42 2.99573227355399 2.32630161961136 4.26705113365158 4.51800297726962 -0.25095184361804 1.2895115740625 0.96247811167263 0.248432795742748 0.19460999704519 0.260735117583014 0.545763581138284 NA NA NA 0.637093345972192 99.311357293691 a6340 loss_cnaBRCA7_(FAS,PTEN) 184 BMS-754807 IGF1R 4 44 0.940007258491471 NA 2.11757152015059 1.58225963054618 0.535311889604409 0.675186141653378 1.73318743171824 0.317774471370859 0.792836014515274 0.30885978042993 0.545854503534882 NA NA NA 0.247607273908784 99.311357293691 a6341 gain_cnaBRCA64_(SDHC) 1023 GW 441756 NTRK1 9 36 0.693147180559945 NA 2.59638672714605 2.30001180683188 0.296374920314163 1.24175190750863 1.32099993080246 0.226825625673253 0.238674825882725 0.224356499499683 0.54596706460252 NA NA NA 0.538300015767363 99.311357293691 a6342 loss_cnaBRCA36_(FAT1,IRF2) 265 Tubastatin A HDAC6 9 40 2.99573227355399 NA 4.88201346737561 4.6489523491536 0.233061118222008 0.856468207489707 1.07219726402388 0.224389244732885 0.27211882027134 0.217367760618364 0.545974769653225 NA NA NA 0.494013352818519 99.311357293691 a6343 loss_cnaBRCA42 229 LY317615 PRKCB (PKCbeta) 3 46 2.99573227355399 2.32630161961136 3.90953113059712 3.32265167688011 0.586879453717006 1.27789833770468 1.63303515177032 0.362380839203338 0.459253632625536 0.359379559638253 0.546019445153545 NA NA NA 0.515602730310549 99.311357293691 a6344 gain_cnaBRCA15 345 KIN001-270 CDK9 22 27 2.99573227355399 NA 5.17424607724897 5.05327217485847 0.120973902390499 0.803047684726177 0.588682870375024 0.174638530753901 0.150643485675135 0.205499273850845 0.546085257311215 NA NA NA 0.559215224793487 99.311357293691 a6345 loss_cnaBRCA18 1243 piperlongumine Increases ROS levels 15 32 2.30258509299405 NA 1.82125168948325 1.65821380542624 0.163037884057009 0.71107141889007 0.914846796450587 0.190318035851561 0.229284822488716 0.178213319092947 0.546107719118075 NA NA NA 0.509584048049705 99.311357293691 a6346 gain_cnaBRCA10_(MDM2,NUP107) 306 TG101348 JAK2 5 43 2.32630161961136 NA 2.8934949800653 3.26342311207478 -0.369928132009481 1.06736417516489 1.30676487842061 0.287274744267344 0.346580989522468 0.283086986892841 0.546184723583221 NA NA NA 0.503720100466409 99.311357293691 a6347 gain_cnaBRCA47_(EGFR) 193 GW-2580 CSF1R (cFMS) 7 41 2.99573227355399 NA 5.62231532643224 5.43625508186129 0.186060244570952 0.64109961054723 0.763226082168605 0.248601545662644 0.290220492275974 0.243781297465997 0.546250904849551 NA NA NA 0.507870450362029 99.311357293691 a6348 gain_cnaBRCA13_(FGFR1,WHSC1L1) 55 A-770041 SRC family 3 9 1.63315443905142 NA 3.08314804232649 2.5788691458195 0.504278896506995 1.62409664270821 1.083663912651 0.416347290397773 0.310498084440407 0.46534621169894 0.546269403784271 NA NA NA 0.654820166806832 99.311357293691 a6349 gain_cnaBRCA12_(TERT) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 10 35 0.693147180559945 NA 0.381148538183561 0.695403317833461 -0.3142547796499 1.07437485148053 1.52357257117748 0.218052782677871 0.292500126205342 0.206261772884917 0.546306614733616 NA NA NA 0.469388091580053 99.311357293691 a6350 loss_cnaBRCA60 1243 piperlongumine Increases ROS levels 3 44 2.30258509299405 NA 2.00109251027877 1.69041680875118 0.310675701527585 0.274279958872865 0.874362688336567 0.362657044294595 1.13269559615032 0.355316741750074 0.5463998918078 NA NA NA 0.185720466338431 99.311357293691 a6351 gain_cnaBRCA13_(FGFR1,WHSC1L1) 158 PF-562271 FAK 10 35 0.940007258491471 NA 2.55261698826752 2.27057398192122 0.282043006346306 1.39495566716251 1.26567313309416 0.21799554765265 0.202187792046475 0.222840320278272 0.546411498171199 NA NA NA 0.57453793407603 99.311357293691 a6352 gain_cnaBRCA8_(CHD4,WNK1) 192 LFM-A13 BTK 3 45 2.77258872223978 NA 4.51023243139003 4.81448597045348 -0.304253539063446 0.765991498890215 0.842958180268098 0.362310757841413 0.397202239847643 0.360935508054125 0.546431877750689 NA NA NA 0.567459333901461 99.311357293691 a6353 ARID1A_mut 1061 SB590885 BRAF 4 38 1.6094379124341 NA 4.32792273117796 3.97864737696605 0.349275354211908 0.699199509978988 1.11819475304378 0.319744060629067 0.499536039752666 0.312356459607026 0.546444101129621 NA NA NA 0.417357977601142 99.311357293691 a6354 gain_cnaBRCA8_(CHD4,WNK1) 1026 17-AAG HSP90 3 40 0 NA -0.28904189294118 -0.941744007022201 0.652702114081021 1.21819518330394 1.8181567842992 0.363915790811895 0.5357943645047 0.35899110556222 0.546583449322801 NA NA NA 0.45933868780375 99.311357293691 a6355 loss_cnaBRCA20 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 3 40 1.6094379124341 NA 3.35294871954348 2.83158472272872 0.52136399681476 1.06607829179584 1.44924819320756 0.363843162984154 0.489048506875144 0.359747901883423 0.546663143096074 NA NA NA 0.493539756594205 99.311357293691 a6356 gain_cnaBRCA8_(CHD4,WNK1) 173 FH535 unknown 3 45 3.46573590279973 NA 1.13704153043177 1.60206183951497 -0.465020309083202 1.26422401458559 1.28564834278087 0.361961174484566 0.367830624729616 0.361701013884838 0.546817507005164 NA NA NA 0.593575440506456 99.311357293691 a6357 loss_cnaBRCA29_(MAP2K4) 192 LFM-A13 BTK 7 41 2.77258872223978 NA 4.61742801135035 4.82586755817376 -0.20843954682341 0.960516919431372 0.820121328994933 0.248211472647048 0.217007678476717 0.254156963676161 0.546878261844853 NA NA NA 0.603770201076357 99.311357293691 a6358 loss_cnaBRCA33 1059 AZD8055 MTORC1/2 5 38 0.693147180559945 NA -0.127954021681799 0.164428727771788 -0.292382749453587 1.69361772598 0.907854808206603 0.288988470787001 0.172637983748312 0.322058931461922 0.546890656847478 NA NA NA 0.7226828630211 99.311357293691 a6359 gain_cnaBRCA62 1018 ABT-888 PARP1, PARP2 8 37 1.6094379124341 NA 4.53287783831402 4.37501097120202 0.157866867111998 1.10096514420526 0.543667080738841 0.236711021335526 0.143389523222332 0.290374151213015 0.546979096029655 NA NA NA 0.703288032261008 99.311357293691 a6360 POLR2B_mut 157 JNK-9L JNK 3 44 1.63315443905142 NA -0.303323466277119 0.0803330090148645 -0.383656475291983 1.11147274797873 1.05713881104773 0.362072324519095 0.345178481424473 0.362919676472516 0.547044339590006 NA NA NA 0.61453013151944 99.311357293691 a6361 loss_cnaBRCA7_(FAS,PTEN) 1066 AZD6482 PI3Kbeta 4 39 1.6094379124341 NA 2.38473046947169 1.92436273218547 0.460367737286217 1.2239600158862 1.46017951661542 0.31876877520591 0.376129719362517 0.31528160205487 0.54709210939666 NA NA NA 0.521593999633324 99.311357293691 a6362 MLL3_mut 1067 CCT007093 PPM1D 3 43 1.88706964903238 NA 3.75056292269393 4.10901343096759 -0.358450508273658 1.50385937850635 0.957965289112517 0.362314609401947 0.238353740646732 0.374179014988879 0.547142385206902 NA NA NA 0.721455612724239 99.311357293691 a6363 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 88 MS-275 HDAC 3 11 1.6094379124341 NA 1.71000523999849 0.983490636015971 0.726514603982518 2.22891896209304 1.70234440039323 0.403432887000858 0.32594931280063 0.426772986602885 0.547239433231633 NA NA NA 0.640340592038737 99.311357293691 a6364 loss_cnaBRCA33 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 6 39 -0.669430653942629 NA -4.04872453198956 -3.39964794533722 -0.649076586652337 2.09936566567074 2.48173517152704 0.265976431189702 0.309177480258047 0.261541438465794 0.547358785683014 NA NA NA 0.513169565175405 99.311357293691 a6365 loss_cnaBRCA33 1194 SB-505124 TGFR1 (ALK5) 5 42 2.30258509299405 NA 4.15289326672237 4.41710692525965 -0.264213658537279 0.453910972886869 0.95486627795929 0.286742315480909 0.582082554331927 0.27670226149566 0.547486164660002 NA NA NA 0.319403469185308 99.311357293691 a6366 gain_cnaBRCA9_(KRAS) 1026 17-AAG HSP90 4 39 0 NA -1.41417957752289 -0.843081221785129 -0.571098355737757 0.946190436947093 1.84397938389989 0.318410592361044 0.603576545943985 0.30970972925409 0.547540524493308 NA NA NA 0.347121048265255 99.311357293691 a6367 loss_cnaBRCA38 1133 JNJ-26854165 MDM2 3 40 2.30258509299405 NA 2.67305257524428 2.99099802126788 -0.317945446023602 0.983111720042522 0.869985350043919 0.363016577159798 0.323407237999208 0.365460689662822 0.547570567491335 NA NA NA 0.635509613053443 99.311357293691 a6368 POLR2B_mut 194 AUY922 HSP90 3 44 -1.36257783450257 NA -2.98065985779805 -2.35373029415482 -0.626929563643235 1.79432373227736 1.73104032844295 0.361571515797594 0.349396016095455 0.362169242011334 0.547596613960117 NA NA NA 0.610611896523803 99.311357293691 a6369 TP53_mut 1005 Cisplatin DNA crosslinker 35 10 1.79175946922805 2.30258509299405 3.61274645605987 3.87076338592814 -0.25801692986827 1.16184831647669 1.27834607434506 0.217336363999795 0.222074539515371 0.201836525371629 0.547620199076611 NA NA NA 0.5753064558159 99.311357293691 a6370 ASH1L_mut 200 LAQ824 HDAC 3 45 0.0237165266173161 NA -3.16387006627427 -2.65250723279237 -0.511362833481905 1.18287823072 1.42552012506068 0.361173922733143 0.432303867128103 0.358720178335004 0.547686442422455 NA NA NA 0.537689603329091 99.311357293691 a6371 gain_cnaBRCA58_(CCND1) 1502 Bicalutamide ANDR (androgen receptor) 9 36 2.30258509299405 NA 4.45247307426219 4.58476064762064 -0.132287573358449 0.414591897137436 0.618244642443169 0.225846236795691 0.319079013053156 0.213972858439463 0.547694614774913 NA NA NA 0.452741604937601 99.311357293691 a6372 loss_cnaBRCA17 329 QL-XI-92 DDR1 10 38 2.32630161961136 NA 4.09142661560315 4.29594259361095 -0.204515978007793 0.910905457720299 0.959344695158592 0.215265972420284 0.224519434233746 0.213182997769101 0.547701214583267 NA NA NA 0.541761284053041 99.311357293691 a6373 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 230 GSK429286A ROCK2 9 40 2.99573227355399 2.32630161961136 5.56963990078484 5.36857291519238 0.201066985592464 0.400103712039875 0.971452344024992 0.223361620227402 0.502537166094637 0.206975655397967 0.547807820605132 NA NA NA 0.330400475716433 99.311357293691 a6374 gain_cnaBRCA63 1529 MLN4924 NEDD8-activating enzyme 4 33 0 NA 0.858479852068451 0.309910474808067 0.548569377260384 3.37589360717877 1.4559785194626 0.321299696760763 0.162496050258771 0.376770240719526 0.547853345788294 NA NA NA 0.768148879724786 99.311357293691 a6375 gain_cnaBRCA48 1006 Cytarabine DNA synthesis 5 40 0.693147180559945 NA 0.816663701949155 1.25751697139958 -0.440853269450423 0.520797246331708 1.60239347851238 0.287333902217243 0.846496928614006 0.275121732185093 0.547863045561814 NA NA NA 0.217725120587969 99.311357293691 a6376 NF1_mut 133 Doxorubicin DNA intercalating 5 43 0.0237165266173161 NA -0.558832350799072 -1.08550691757288 0.52667456677381 0.975133522858262 1.90380517528362 0.285966514789666 0.540105077333459 0.276643100676176 0.548006715985387 NA NA NA 0.343564311209313 99.311357293691 a6377 gain_cnaBRCA63 1019 Bosutinib SRC, ABL, TEC 6 39 0.693147180559945 NA 2.87829279595784 2.62941480521031 0.248877990747531 1.17787264056773 0.901334080697803 0.265416243114551 0.211294483100968 0.27612180220108 0.548199271347396 NA NA NA 0.637912230584518 99.311357293691 a6378 PIK3CA_mut 150 Bicalutamide ANDR (androgen receptor) 17 31 0.0237165266173161 NA 2.8363609588752 2.72213146402747 0.114229494847727 0.727565556496391 0.563897083301153 0.182562714915665 0.157002339964803 0.202571529859682 0.548205871727508 NA NA NA 0.579177336502208 99.311357293691 a6379 loss_cnaBRCA7_(FAS,PTEN) 330 XMD13-2 RIPK 4 44 2.32630161961136 NA 3.36746463645064 3.7531627541328 -0.385698117682163 0.632282280824064 1.25172136768848 0.315902434556841 0.610009372996308 0.308134164390291 0.548213291295119 NA NA NA 0.338892871543261 99.311357293691 a6380 loss_cnaBRCA20 194 AUY922 HSP90 3 44 -1.36257783450257 NA -1.80775478224399 -2.43370109476078 0.625946312516784 0.911602789987804 1.76286066673378 0.360999825615489 0.686643699856555 0.355074183869866 0.548227402100069 NA NA NA 0.363134938431784 99.311357293691 a6381 gain_cnaBRCA15 290 KIN001-260 IKK 22 27 2.99573227355399 NA 4.9440068552935 5.12560952959668 -0.181602674303184 1.36760414803406 0.682376563502484 0.173683391234849 0.132788917439479 0.266132637045825 0.548274358250318 NA NA NA 0.574418500013551 99.311357293691 a6382 gain_cnaBRCA10_(MDM2,NUP107) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 5 43 0.246860077931526 2.32630161961136 0.159690969692397 -0.314328945904746 0.474019915597143 1.68203414981471 1.6571601918093 0.285668098258522 0.281813490914771 0.286043508611924 0.548422759701862 NA NA NA 0.57655997091947 99.311357293691 a6383 loss_cnaBRCA20 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 42 2.30258509299405 NA 3.61791500892136 3.14536354745408 0.472551461467272 1.19717237941029 1.31245156526506 0.361467129303672 0.394722990268156 0.360052495630067 0.548457294601825 NA NA NA 0.570041816462022 99.311357293691 a6384 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1049 PD-173074 FGFR1, FGFR3 16 27 0.693147180559945 NA 2.80023618272346 3.01926194970707 -0.219025766983604 1.08214685178305 1.18334894017656 0.190895460696122 0.202399301557561 0.185089756324051 0.54846922364495 NA NA NA 0.53980959055536 99.311357293691 a6385 gain_cnaBRCA10_(MDM2,NUP107) 273 CUDC-101 HDAC, EGFR 5 44 1.63315443905142 NA 0.376543063748554 -0.0724657357314404 0.449008799479994 1.53967839045808 1.5773643449103 0.285231252315168 0.291625057715077 0.284657632162675 0.548497335080713 NA NA NA 0.564603429258587 99.311357293691 a6386 gain_cnaBRCA19 1043 JNK Inhibitor VIII JNK 3 40 2.30258509299405 NA 4.54501949534306 4.81625455761397 -0.27123506227091 0.480786552133883 0.760196480817133 0.362134947707787 0.564148604130217 0.3567959982916 0.548539269266924 NA NA NA 0.439881583636161 99.311357293691 a6387 gain_cnaBRCA19 1378 Bleomycin (50 uM) DNA damage 4 44 3.91202300542815 NA 3.26520782989408 3.86249122983215 -0.597283399938067 1.34449496543019 1.92525346945813 0.315552586796117 0.44424368651091 0.310236241312254 0.548654679668038 NA NA NA 0.458283878246419 99.311357293691 a6388 PTEN_mut 1052 RO-3306 CDK1 6 37 1.6094379124341 NA 3.24944905712845 3.57046649095364 -0.321017433825192 1.83827924457327 1.08964440133503 0.266165368375636 0.174629308780403 0.294607519142834 0.548661191731762 NA NA NA 0.692878136371625 99.311357293691 a6389 gain_cnaBRCA16 1241 CHIR-99021 GSK3B 16 30 2.30258509299405 NA 4.35123355842919 4.16762231065108 0.183611247778111 0.892447175785929 1.02431085051317 0.187100688466929 0.205739065302565 0.179253444094752 0.548688593264093 NA NA NA 0.532376444499319 99.311357293691 a6390 loss_cnaBRCA38 261 TL-1-85 MAP3K7 (TAK1) 4 45 2.32630161961136 NA 3.67285436468753 4.05609109716539 -0.383236732477857 0.528857323278208 1.24939731217515 0.315102943287166 0.724650516517957 0.306737279441284 0.548790529043248 NA NA NA 0.276941894652284 99.311357293691 a6391 gain_cnaBRCA47_(EGFR) 1219 PFI-1 BRD2, BRD3, BRD4 7 40 2.30258509299405 NA 3.38346233130456 3.13555934038515 0.247902990919405 0.672038097144072 1.04311026419034 0.247504847237856 0.368882347552775 0.237657512757605 0.548806249999408 NA NA NA 0.429258639767915 99.311357293691 a6392 gain_cnaBRCA8_(CHD4,WNK1) 253 XMD14-99 EPHB3, CAMK1 4 44 2.32630161961136 NA 5.15740877746021 4.91271030047413 0.244698476986072 0.643869850759746 0.78427867506594 0.315375161233695 0.380043384074182 0.312004501417177 0.548878599361809 NA NA NA 0.516312081611455 99.311357293691 a6393 gain_cnaBRCA27_(CLTC,PPM1D) 263 FR-180204 ERK 9 40 2.99573227355399 NA 5.22411410357596 5.38798331617332 -0.163869212597359 0.536881552992552 0.770208381664077 0.222727837065731 0.305224144290226 0.212759581041316 0.548939910842968 NA NA NA 0.459773599169994 99.311357293691 a6394 loss_cnaBRCA24 197 Bryostatin 1 PRKC 3 45 -4.8283137373023 NA -2.47960781950778 -2.82861699666275 0.349009177154968 0.438691850120051 0.987297994459816 0.359833108278441 0.795567952902381 0.353499327572242 0.549167998673873 NA NA NA 0.306811848168218 99.311357293691 a6395 gain_cnaBRCA64_(SDHC) 1061 SB590885 BRAF 7 35 1.6094379124341 NA 3.78420239958175 4.05745355578142 -0.273251156199663 2.26236290604079 0.707650892838992 0.2501321406659 0.120781310315002 0.386138361393737 0.549170868287023 NA NA NA 0.761967311201888 99.311357293691 a6396 gain_cnaBRCA12_(TERT) 1248 FK866 NAMPT 10 34 0 NA -0.193404402635421 -0.785206302051606 0.591801899416185 2.70358855858785 2.73037401229293 0.217202393226305 0.218894956311436 0.216747557935917 0.54923823266608 NA NA NA 0.552950326868367 99.311357293691 a6397 loss_cnaBRCA7_(FAS,PTEN) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 4 42 1.63315443905142 NA 1.47576457603296 1.98048358313585 -0.504719007102893 1.00452754516972 1.63319102757619 0.315804161695034 0.502444168435039 0.30903856228744 0.549259896613 NA NA NA 0.412922778470569 99.311357293691 a6398 PTEN_mut 202 GSK-1904529A IGF1R 8 40 0.0237165266173161 NA 2.02693069579337 2.2222231707245 -0.195292474931138 0.501802605248116 0.88255073383039 0.233638466012115 0.389181867309308 0.221281867936976 0.549304186905123 NA NA NA 0.398857471504395 99.311357293691 a6399 loss_cnaBRCA18 281 CH5424802 ALK 15 33 1.63315443905142 NA 3.43727273273058 3.63795185028219 -0.200679117551613 1.06024925695408 1.07257995475718 0.187753738501534 0.189275414470113 0.18709944807522 0.549513119281401 NA NA NA 0.549746594498576 99.311357293691 a6400 gain_cnaBRCA62 11 Paclitaxel Microtubules 4 8 -2.27886856637673 NA -3.55295516282503 -2.8648287706832 -0.688126392141825 0.503201241190954 2.14336607606475 0.379273996816624 1.36749740623294 0.32104939973914 0.549534257729552 NA NA NA 0.412745818784053 99.311357293691 a6401 gain_cnaBRCA16 274 PXD101, Belinostat HDAC 16 32 2.99573227355399 NA 0.486790514902963 0.76385976149732 -0.277069246594357 1.7991024229252 1.33329623293179 0.184570590765019 0.154004153995782 0.207807717258083 0.54959891859948 NA NA NA 0.590454913271419 99.311357293691 a6402 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 326 GSK690693 AKT 5 43 2.32630161961136 NA 2.44545461324375 2.99703448740072 -0.551579874156978 2.86643869895097 1.82367803657898 0.284793722458855 0.192426886491185 0.30245463458653 0.549642716193019 NA NA NA 0.693922902340057 99.311357293691 a6403 PIK3CA_mut 89 Parthenolide NFKB1 4 10 1.6094379124341 NA 3.62090462983419 3.10145004369687 0.519454586137313 1.30490732966147 1.46454837916797 0.364193653309963 0.398077759492756 0.354685849594413 0.549656515355234 NA NA NA 0.539286614977916 99.311357293691 a6404 loss_cnaBRCA33 34 Imatinib ABL, KIT, PDGFR 5 9 0.693147180559945 NA 2.88336525010474 2.71853225846195 0.164832991642788 0.370292509033652 0.526457223050245 0.343344708092719 0.445142657821922 0.313098547091368 0.549679822141115 NA NA NA 0.508576809297874 99.311357293691 a6405 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 6 42 2.77258872223978 NA -0.761706420613829 -0.390073027384823 -0.371633393229006 1.3380632843272 1.42184613888216 0.263013913624864 0.277739773284242 0.261373845640696 0.54970738823189 NA NA NA 0.548696537972805 99.311357293691 a6406 gain_cnaBRCA10_(MDM2,NUP107) 282 EKB-569 EGFR 5 42 0.916290731874155 2.99573227355399 2.11914577492541 1.5136533660054 0.605492408920004 1.40564784885549 2.18113881957228 0.285111438457594 0.430756828186383 0.2776037927924 0.549757354345115 NA NA NA 0.425651865470926 99.311357293691 a6407 gain_cnaBRCA19 208 SB-715992 KIF11 4 45 -2.05572501506252 NA -1.73462297594713 -1.19592384424436 -0.538699131702768 1.99851919004909 1.6929984216231 0.314270161659459 0.26954914137679 0.318192341364566 0.549843306687687 NA NA NA 0.633421636075261 99.311357293691 a6408 loss_cnaBRCA57 171 AKT inhibitor VIII AKT1, AKT2, AKT3 5 42 0.940007258491471 NA 1.56824873685597 1.92680274522364 -0.358554008367662 1.47893128742326 1.234310089586 0.28502319031324 0.242441289474895 0.290489408936068 0.549880387108224 NA NA NA 0.62606057989747 99.311357293691 a6409 loss_cnaBRCA34 263 FR-180204 ERK 5 44 2.99573227355399 NA 5.54550154847591 5.33656481447129 0.20893673400461 0.207894782957956 0.766598629232961 0.28397554395001 1.00501191531519 0.272550362128442 0.550252397515873 NA NA NA 0.173437557978618 99.311357293691 a6410 loss_cnaBRCA18 1378 Bleomycin (50 uM) DNA damage 16 32 3.91202300542815 NA 4.04508948236164 3.69653167857514 0.3485578037865 1.66007912384319 1.99581055464928 0.184140830571758 0.209964572640108 0.174644734178066 0.550525113537281 NA NA NA 0.526351114068056 99.311357293691 a6411 gain_cnaBRCA14_(RAD21) 263 FR-180204 ERK 21 28 2.99573227355399 NA 5.28491506900421 5.41261225464386 -0.127697185639653 0.811410839796112 0.674273542095784 0.173558034329862 0.157376731215152 0.189384838151507 0.550580573361518 NA NA NA 0.561722275273749 99.311357293691 a6412 loss_cnaBRCA18 91 KIN001-135 IKKE 6 8 1.6094379124341 NA 3.62567454914427 3.76176121849467 -0.136086669350403 0.49729408333513 0.334925982763616 0.331546235741806 0.27365431021767 0.40631863860634 0.550739483454363 NA NA NA 0.577956992119306 99.311357293691 a6413 BRCA2_mut 261 TL-1-85 MAP3K7 (TAK1) 6 43 2.32630161961136 NA 3.74528274259065 4.06380977617787 -0.318527033587222 0.824084902794906 1.25482421089265 0.261887667498564 0.386522107742696 0.253841957161975 0.550771134834106 NA NA NA 0.432624305130286 99.311357293691 a6414 gain_cnaBRCA27_(CLTC,PPM1D) 17 Cyclopamine SMO 3 10 2.77258872223978 NA 4.95619659227515 4.61747343304514 0.338723159230015 0.554804519536659 0.886618660366219 0.405102906226749 0.610527036645082 0.382039285176002 0.550813236790938 NA NA NA 0.459049334458561 99.311357293691 a6415 loss_cnaBRCA24 257 NPK76-II-72-1 PLK3 3 46 2.32630161961136 NA 2.9444513855788 3.51381957390474 -0.569368188325942 1.66836874549334 1.58684225173538 0.358003901499307 0.341272389490597 0.358805790369697 0.55086032212935 NA NA NA 0.618107736748233 99.311357293691 a6416 loss_cnaBRCA22_(SYNCRIP,ZNF292) 298 OSI-930 KIT, VEGFR, PDGFR 18 30 2.32630161961136 NA 4.01156256251205 3.85445013680034 0.157112425711711 0.955500122437502 0.827637963461729 0.179134192337258 0.164429519183016 0.189832309110814 0.550899545547803 NA NA NA 0.566445096975577 99.311357293691 a6417 loss_cnaBRCA33 279 BIX02189 MAP2K5 (MEK5) 6 43 2.99573227355399 NA 4.81989132717717 5.05630460975939 -0.236413282582225 0.675410134872074 0.926624855286793 0.261742887725756 0.350029219841367 0.255133759075623 0.550990574354322 NA NA NA 0.467599755452904 99.311357293691 a6418 NF1_mut 258 STF-62247 stimulates autophagy 5 44 2.32630161961136 NA 4.3852982547645 4.65874570658866 -0.273447451824164 0.819622471797606 0.977170524263303 0.283434454606953 0.33362610376511 0.279835960085184 0.55100953945847 NA NA NA 0.517533500196338 99.311357293691 a6419 gain_cnaBRCA62 1194 SB-505124 TGFR1 (ALK5) 8 39 2.30258509299405 NA 4.5672059534637 4.35244383504634 0.214762118417362 1.12733276498442 0.878339877729242 0.233056708540059 0.190504636330986 0.24450912894059 0.551206638730872 NA NA NA 0.623823246651357 99.311357293691 a6420 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 5 21 2.30258509299405 NA 2.9927533960478 2.6198257494413 0.372927646606501 1.92940058194679 1.04944800734561 0.300687938490915 0.193286790776341 0.355356000484248 0.551340685507851 NA NA NA 0.694995977090642 99.311357293691 a6421 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1194 SB-505124 TGFR1 (ALK5) 15 32 2.30258509299405 NA 4.50679755919752 4.33378105645482 0.173016502742699 0.878950555493934 0.940094937993672 0.187753845962398 0.19684440912091 0.184041521499888 0.551507381821911 NA NA NA 0.543251599488708 99.311357293691 a6422 CDH1_mut 226 GSK1070916 AURKB 4 45 0.940007258491471 2.32630161961136 2.96568125292501 2.35401583865674 0.611665414268269 0.426436209389414 2.01732531907586 0.312895996721626 1.43436556465051 0.30320613561152 0.551582728023291 NA NA NA 0.111852231204201 99.311357293691 a6423 gain_cnaBRCA47_(EGFR) 1013 Nilotinib ABL 7 33 0.693147180559945 NA 3.00453943665455 3.24498543150426 -0.240445994849707 0.974725990844489 0.959493959006012 0.249965934383356 0.246680602659818 0.250596673999696 0.551606849048773 NA NA NA 0.567448817645546 99.311357293691 a6424 gain_cnaBRCA48 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 5 41 2.30258509299405 NA 1.16018735157914 1.44402705720063 -0.283839705621491 0.687894609652248 1.02489857872048 0.284132125240593 0.412620918435428 0.276944188932184 0.551705229529009 NA NA NA 0.442428604140944 99.311357293691 a6425 CDH1_mut 1149 TW 37 BCL2, BCL2L1 4 39 1.6094379124341 NA 0.215438347787385 -0.179083995138206 0.394522342925591 1.28667948323024 1.24939246303125 0.315073822005794 0.306620528319247 0.315771348554808 0.551726919074718 NA NA NA 0.592829218887553 99.311357293691 a6426 ASH1L_mut 1371 PLX4720 (rescreen) BRAF 3 44 2.30258509299405 NA 4.38555817029758 4.72907387833372 -0.343515708036138 0.461224813267897 0.97701232317933 0.357832145262922 0.744790172068672 0.351598132271548 0.551729248671429 NA NA NA 0.332339074471488 99.311357293691 a6427 loss_cnaBRCA20 1047 Nutlin-3a MDM2 3 40 2.07944154167984 1.38629436111989 4.54407849513815 4.1816595235276 0.362418971610547 0.863276933831096 1.01620309579137 0.359086287190764 0.419817740295903 0.356640294751623 0.551895773835126 NA NA NA 0.548996423244752 99.311357293691 a6428 ASH1L_mut 326 GSK690693 AKT 3 45 2.32630161961136 NA 3.58829347452896 2.89633056890807 0.691962905620892 0.997048330260807 1.96894885185744 0.35726014974486 0.69401139806321 0.351437725245181 0.552016741503089 NA NA NA 0.358993836847155 99.311357293691 a6429 ASH1L_mut 281 CH5424802 ALK 3 45 1.63315443905142 NA 3.21726730488941 3.59910444745784 -0.381837142568426 1.09253488253681 1.06780857694125 0.357225877293784 0.349496522876981 0.357589506971561 0.552054738001514 NA NA NA 0.610531011902166 99.311357293691 a6430 PIK3CA_mut 54 CGP-082996 CDK4 4 8 1.63315443905142 NA 3.06983655175887 2.67871335256774 0.391123199191132 1.28912938492772 0.909325754358761 0.376817965951486 0.303401042412093 0.430124405160992 0.552075091223157 NA NA NA 0.612607106839009 99.311357293691 a6431 loss_cnaBRCA28_(GPS2) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 4 41 -0.669430653942629 NA -4.18424435153785 -3.41808877204726 -0.766155579490595 1.28666243758257 2.50581340899808 0.313921108101339 0.595459661455633 0.305751248971459 0.552124962452593 NA NA NA 0.351048690385999 99.311357293691 a6432 gain_cnaBRCA14_(RAD21) 134 Etoposide TOP2 21 26 2.77258872223978 NA 2.68780110689903 2.30692140423941 0.380879702659624 2.2858048679324 2.06739552890324 0.175748546939794 0.16662826648197 0.184231656368959 0.552165422613933 NA NA NA 0.556758881120695 99.311357293691 a6433 BRCA1_mut 157 JNK-9L JNK 4 43 1.63315443905142 NA -0.247710174506194 0.0840819231592433 -0.331792097665438 0.391204559267266 1.09192348374162 0.313093184397758 0.848129424378108 0.303860208710328 0.552211212820998 NA NA NA 0.230116156057011 99.311357293691 a6434 loss_cnaBRCA18 196 Phenformin AAPK1 (AMPK) agonist 15 33 8.29404964010203 NA 7.43511992192263 7.09605543047218 0.339064491450442 1.55631025058448 1.92164668125883 0.186479009265347 0.217864330921875 0.176444762066421 0.552216351441071 NA NA NA 0.521133678477156 99.311357293691 a6435 loss_cnaBRCA38 158 PF-562271 FAK 4 41 0.940007258491471 NA 2.70323817437175 2.29715381835197 0.40608435601978 0.496286092065284 1.33470505958924 0.313830454459416 0.818246496350258 0.304250255966478 0.552239294778989 NA NA NA 0.243888550486623 99.311357293691 a6436 gain_cnaBRCA64_(SDHC) 1149 TW 37 BCL2, BCL2L1 8 35 1.6094379124341 NA 0.0969907712230654 -0.197098531115001 0.294089302338066 1.05972744028808 1.28823031301022 0.234863157271189 0.277514095754772 0.228289382238542 0.552256290514085 NA NA NA 0.509994226611604 99.311357293691 a6437 loss_cnaBRCA60 1375 Temozolomide DNA akylating agent 3 43 3.40119738166216 NA 5.66588744111934 5.9164681559489 -0.250580714829566 0.703898620476532 0.700586238371544 0.357595880413742 0.355989779692884 0.357672904640576 0.552352532384126 NA NA NA 0.604723877738093 99.311357293691 a6438 NF1_mut 1022 AZD7762 CHEK1, CHEK2 4 41 0.693147180559945 NA 1.37038259815561 0.859323181956252 0.511059416199355 0.602722855813603 1.68101252016943 0.313704705982056 0.847917763977087 0.304018804183471 0.552397908611059 NA NA NA 0.233353612056975 99.311357293691 a6439 TP53_mut 134 Etoposide TOP2 37 10 2.77258872223978 NA 2.57548211863661 2.11309413655498 0.462387982081625 2.04115820416168 2.61120589165731 0.213357663191897 0.226532162543242 0.177078331340678 0.552419693735776 NA NA NA 0.613249964300678 99.311357293691 a6440 gain_cnaBRCA19 1046 681640 WEE1, CHEK1 3 33 0.693147180559945 NA 2.98928277608688 2.60147780246586 0.387804973621012 0.834259407255067 1.08481344225728 0.361860407645839 0.464849386472 0.357485405798501 0.552433367613039 NA NA NA 0.514256539086365 99.311357293691 a6441 loss_cnaBRCA33 177 GSK-650394 SGK3 5 42 2.77258872223978 NA 3.58367813457167 4.0657198441695 -0.482041709597825 1.16959904121677 1.7456054231519 0.283168249653262 0.412142702422483 0.276145859313063 0.552469727372662 NA NA NA 0.442218953747525 99.311357293691 a6442 gain_cnaBRCA30_(CRNKL1,FOXA2) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 5 42 2.77258872223978 NA 5.27108590924653 4.97992714644885 0.291158762797681 1.47891899565914 0.973618702237184 0.283053448689685 0.196872691237504 0.299048038137164 0.552630182818601 NA NA NA 0.687813653103459 99.311357293691 a6443 gain_cnaBRCA63 151 QS11 ARFGAP 6 42 2.32630161961136 NA 3.42103200977807 3.80893816175238 -0.38790615197431 1.75668474317673 1.44984283268851 0.260993586031227 0.220817169091384 0.267550484251453 0.5527653602867 NA NA NA 0.624041097592603 99.311357293691 a6444 loss_cnaBRCA23 288 KIN001-055 JAK3, MNK1 3 46 2.32630161961136 NA 4.62580361282635 4.32030286202515 0.305500750801198 0.732056827634452 0.863531033677666 0.355917653052017 0.417318354626081 0.353780858923055 0.553175351881786 NA NA NA 0.550279472182079 99.311357293691 a6445 gain_cnaBRCA9_(KRAS) 1017 Olaparib PARP1, PARP2 4 41 1.6094379124341 NA 4.32878805396621 4.04925029721795 0.279537756748261 0.529288790927168 0.914410584353907 0.313050454721715 0.528138440752897 0.305702669600848 0.55322352688911 NA NA NA 0.395502587581226 99.311357293691 a6446 gain_cnaBRCA63 1025 SB 216763 GSK3A, GSK3B 6 33 2.30258509299405 NA 5.06673465293145 4.85687527511947 0.209859377811977 1.04255821710937 0.74322313640931 0.265534882377155 0.201292718591619 0.282363892526083 0.553282318411631 NA NA NA 0.653882840415932 99.311357293691 a6447 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 341 EX-527 SIRT1 9 40 2.99573227355399 NA 5.52364165058418 5.66832834613899 -0.144686695554814 0.35527264285056 0.702989807300776 0.220245872237926 0.407255381089599 0.205816206795882 0.553384741109318 NA NA NA 0.381711149004827 99.311357293691 a6448 loss_cnaBRCA7_(FAS,PTEN) 295 NVP-BHG712 EPHB4 4 45 2.32630161961136 NA 4.23949063558476 3.85534981823849 0.384140817346275 0.32552267759018 1.27194635917921 0.31144164593039 1.18007390511174 0.302010233823194 0.553426684077434 NA NA NA 0.145319210627023 99.311357293691 a6449 gain_cnaBRCA48 1170 CCT018159 HSP90 5 38 2.30258509299405 NA 3.64329921982553 3.30329277741867 0.340006442406859 1.19995430510681 1.195778515203 0.284241987260993 0.283349491693014 0.28433897923742 0.553465996721057 NA NA NA 0.576711056601248 99.311357293691 a6450 gain_cnaBRCA48 291 KIN001-266 MAP3K8 (COT) 5 44 2.99573227355399 NA 3.47918594293482 3.81266264373756 -0.333476700802742 1.24973905355894 1.17790189995114 0.281608528843448 0.266837064788114 0.283110758898152 0.55356844031931 NA NA NA 0.594938627251464 99.311357293691 a6451 POLR2B_mut 1005 Cisplatin DNA crosslinker 3 42 1.79175946922805 2.30258509299405 4.06549795369271 3.6418396657214 0.423658287971309 1.69696859635398 1.15673690409003 0.356816846954705 0.249655938761365 0.366252936578167 0.553592538411419 NA NA NA 0.70961015588282 99.311357293691 a6452 NF1_mut 298 OSI-930 KIT, VEGFR, PDGFR 4 44 2.32630161961136 NA 4.1639081388017 3.89059085622773 0.273317282573972 0.974413247425689 0.869918039749003 0.311610292286371 0.280494218747591 0.314187394772078 0.553641001401068 NA NA NA 0.621084993748574 99.311357293691 a6453 gain_cnaBRCA12_(TERT) 1059 AZD8055 MTORC1/2 9 34 0.693147180559945 NA 0.30955619382152 0.0830151706625077 0.226541023159012 1.0741877430182 0.996208957068329 0.223877704394227 0.210895185344872 0.227403118142687 0.553641922698681 NA NA NA 0.578607231278958 99.311357293691 a6454 gain_cnaBRCA64_(SDHC) 1033 Vismodegib SMO 9 36 2.30258509299405 NA 4.89956746464215 4.72482634594181 0.174741118700335 1.04281935179362 0.713761634426296 0.222461454132022 0.167566049095449 0.244817191443454 0.553686518410016 NA NA NA 0.644614172936487 99.311357293691 a6455 gain_cnaBRCA27_(CLTC,PPM1D) 1175 AG-014699 PARP1, PARP2 9 34 1.6094379124341 NA 4.04397511131028 3.81328711429369 0.230687997016589 1.28962329645797 0.957466139926847 0.223813094247519 0.178880140929672 0.240935932245306 0.553755880697047 NA NA NA 0.626542426927151 99.311357293691 a6456 MACF1_mut 1008 Methotrexate Dihydrofolate reductase (DHFR) 3 42 -1.6094379124341 NA 1.04679276512845 0.656639882257106 0.390152882871339 0.693868774188163 1.10975195812561 0.356655731294057 0.562286267065158 0.351567645377542 0.553770892382846 NA NA NA 0.44090395051066 99.311357293691 a6457 loss_cnaBRCA36_(FAT1,IRF2) 301 PHA-793887 CDK-pan 9 39 2.32630161961136 NA 3.21753641336318 2.85413148140431 0.363404931958871 1.54786907576021 1.66811989310543 0.220534488630131 0.234777564620827 0.217853005327059 0.553857497817633 NA NA NA 0.542755960901308 99.311357293691 a6458 NF1_mut 1058 GDC0941 PI3K (class 1) 4 39 1.38629436111989 0.693147180559945 1.741656345435 1.30542269509523 0.436233650339769 0.680701730251633 1.43351568929741 0.313318030665124 0.640858735849706 0.304310342465505 0.553936308359357 NA NA NA 0.327288728283133 99.311357293691 a6459 ARID1A_mut 1527 GDC0941 (rescreen) PI3K 5 40 1.38629436111989 NA 0.688835814445128 1.01713334472843 -0.328297530283297 1.89498508313613 1.05694513276875 0.282840992343016 0.173245443040627 0.310609813229658 0.554113672603213 NA NA NA 0.721863103865842 99.311357293691 a6460 loss_cnaBRCA29_(MAP2K4) 154 CHIR-99021 GSK3B 7 40 0.940007258491471 NA 3.46441098756827 3.24236638680165 0.222044600766616 0.845309351660277 0.918900108725943 0.244157416673317 0.262678509743797 0.241641717808132 0.554203473984753 NA NA NA 0.543270582540226 99.311357293691 a6461 loss_cnaBRCA34 260 NG-25 MAP3K7 (TAK1) 5 44 2.32630161961136 NA 2.88279347597388 3.24533771475503 -0.362544238781158 0.669974670929376 1.33299631131402 0.281062586471857 0.541131261392678 0.271976925745409 0.554334703749298 NA NA NA 0.34349147720524 99.311357293691 a6462 loss_cnaBRCA42 279 BIX02189 MAP2K5 (MEK5) 3 46 2.99573227355399 NA 4.7264778290722 5.0469785368587 -0.3205007077865 0.644759807816279 0.913078619229573 0.354816456925504 0.497085432282133 0.351011075099894 0.554399288761496 NA NA NA 0.486648206740888 99.311357293691 a6463 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 262 VX-11e ERK 6 43 1.63315443905142 NA 4.08084445363195 3.73438880380876 0.346455649823185 1.15498564689268 1.35538523446957 0.259420905141126 0.299965329227486 0.255614153830419 0.554516005459619 NA NA NA 0.522347527983881 99.311357293691 a6464 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1264 SGC0946 Q8TEK3 (DOT1L) 18 28 -0.693147180559945 NA 1.88401909782644 1.99358874113912 -0.109569643312677 0.717668183876736 0.529853941272064 0.179822758236107 0.152674516962418 0.206792164364436 0.554742405595985 NA NA NA 0.581562174665095 99.311357293691 a6465 loss_cnaBRCA29_(MAP2K4) 1050 ZM-447439 AURKB 5 34 1.38629436111989 0.693147180559945 3.21718706905091 2.83950305398675 0.377684015064168 1.02967352650391 1.35437733130959 0.285449244105058 0.366799772299218 0.278861736927459 0.554826901011612 NA NA NA 0.490542769156816 99.311357293691 a6466 gain_cnaBRCA19 193 GW-2580 CSF1R (cFMS) 4 44 2.99573227355399 NA 5.25021286372118 5.48276850423759 -0.232555640516409 1.46468506788364 0.670636550477651 0.310673283795975 0.158775183563818 0.346768514705581 0.554829519183449 NA NA NA 0.772987717742747 99.311357293691 a6467 BRCA1_mut 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 4 42 1.63315443905142 NA 2.39093301561308 1.89332468412822 0.49760833148486 1.65529898721362 1.59414357047082 0.311318941064243 0.300615378447424 0.312147751747287 0.554923705823948 NA NA NA 0.598933161946652 99.311357293691 a6468 gain_cnaBRCA62 302 PI-103 PI3Ka, PRKDC (DNAPK) 10 38 2.32630161961136 NA 0.817025081432931 1.21038265360785 -0.393357572174915 1.72344485307267 1.89283304094291 0.211379661052895 0.228239140622116 0.207814193680266 0.554925060276855 NA NA NA 0.538774133903152 99.311357293691 a6469 gain_cnaBRCA12_(TERT) 330 XMD13-2 RIPK 9 39 2.32630161961136 NA 3.50281966703159 3.77137545447081 -0.268555787439221 0.881121086549512 1.28123185932878 0.219929127910611 0.304788741909345 0.209607484768537 0.554942020821457 NA NA NA 0.463825217730654 99.311357293691 a6470 gain_cnaBRCA10_(MDM2,NUP107) 1175 AG-014699 PARP1, PARP2 3 40 1.6094379124341 NA 4.20321427206936 3.83594737678925 0.367266895280113 0.568071935801183 1.04898442374223 0.35631236453118 0.646514767116838 0.35011663373408 0.554958861591029 NA NA NA 0.388247993885473 99.311357293691 a6471 loss_cnaBRCA33 207 AS601245 JNK 6 42 2.07944154167984 NA 2.55873193547057 2.22441053853334 0.334321396937229 0.915030995319916 1.32660293710611 0.259515509921995 0.365366199229506 0.252013159013901 0.555008025777247 NA NA NA 0.454201564944865 99.311357293691 a6472 loss_cnaBRCA57 208 SB-715992 KIF11 5 44 -2.05572501506252 NA -0.808111415556721 -1.28896608675003 0.480854671193307 1.74687004442531 1.71123938986523 0.280496119694223 0.275266424498967 0.28099789780504 0.555130340275008 NA NA NA 0.584702359081472 99.3153155673545 a6473 loss_cnaBRCA20 202 GSK-1904529A IGF1R 3 45 0.0237165266173161 NA 2.46737032762998 2.17116136472083 0.296208962909154 0.288325362567657 0.852547079820764 0.354328767114815 1.02734272237201 0.347440006446832 0.555271435710813 NA NA NA 0.217141628937914 99.3153155673545 a6474 gain_cnaBRCA63 205 BMS-708163 g-secretase 7 41 2.32630161961136 0.940007258491471 4.75506039788957 4.92068278196378 -0.16562238407421 0.689288627242695 0.680393595362347 0.243004705039412 0.240280163531401 0.243421433127992 0.555287462633261 NA NA NA 0.572091159083089 99.3153155673545 a6475 gain_cnaBRCA61_(NOTCH2) 208 SB-715992 KIF11 3 46 -2.05572501506252 NA -1.809508039782 -1.20275088642258 -0.606757153359413 2.08588126781625 1.69590580655005 0.353936938555753 0.290887675497772 0.357777625983679 0.555377820680244 NA NA NA 0.667123635548764 99.3161356858154 a6476 gain_cnaBRCA62 1017 Olaparib PARP1, PARP2 8 37 1.6094379124341 NA 4.24419656405735 4.03732005106329 0.206876512994053 1.35085493827893 0.773087459285736 0.231667099727399 0.153144876723496 0.267597812523292 0.555517898811799 NA NA NA 0.686501404118434 99.3258454345556 a6477 loss_cnaBRCA29_(MAP2K4) 1161 ZG-10 IRAK1 3 23 2.30258509299405 NA 2.43362085830299 1.91564404099722 0.517976817305767 0.721742719196496 1.45850611507825 0.366872647143337 0.717675154218974 0.355142026454909 0.555665628570863 NA NA NA 0.365402197860174 99.3369200744484 a6478 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1203 QL-XII-61 BTK 5 18 2.30258509299405 NA 3.86466586367427 4.32536247540176 -0.460696611727491 2.42464799302396 1.21598224982825 0.302673163618254 0.190005564953337 0.378867875573482 0.555756775499332 NA NA NA 0.699779287922792 99.3378774854394 a6479 TP53_mut 208 SB-715992 KIF11 38 11 -2.05572501506252 NA -1.318036458813 -0.969970859990084 -0.348065598822914 1.653328071919 1.92328464929979 0.203033079446873 0.210524217627852 0.18097456294347 0.556021982285396 NA NA NA 0.594154907914234 99.3454142393126 a6480 gain_cnaBRCA47_(EGFR) 279 BIX02189 MAP2K5 (MEK5) 7 42 2.99573227355399 NA 5.21469088173687 4.99613357167997 0.218557310056895 1.19149250340854 0.853018468076896 0.241949573091388 0.18343154441313 0.256216387142973 0.556254294831874 NA NA NA 0.655367587775582 99.3454142393126 a6481 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 15 28 0.693147180559945 NA 1.88931795365307 1.57085545093254 0.318462502720523 1.86892343795598 1.5701754254322 0.189766915932496 0.170398902519421 0.202819696170487 0.55638734371613 NA NA NA 0.579056658679517 99.3454142393126 a6482 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 312 AV-951 VEGFR 14 34 -2.05572501506252 NA 0.718006418460332 0.59697502545777 0.121031393002562 0.453283342152438 0.705168431782686 0.187922848837925 0.267010458464763 0.171634729445548 0.556893390903807 NA NA NA 0.483932626592875 99.3454142393126 a6483 loss_cnaBRCA36_(FAT1,IRF2) 178 BAY 61-3606 SYK 9 39 2.07944154167984 NA 2.80902111100167 3.1619216779662 -0.352900566964537 1.86148476913633 1.55513018735162 0.218840117553327 0.189580152798281 0.226926703522825 0.55689571287927 NA NA NA 0.608369553408876 99.3454142393126 a6484 gain_cnaBRCA9_(KRAS) 235 QL-XII-47 BTK, BMX 4 45 2.32630161961136 NA 1.28015933294557 1.74611205143174 -0.465952718486172 1.32480522929947 1.52152306137785 0.308632606834702 0.351714129881989 0.306240983336931 0.556997038605892 NA NA NA 0.544506259949334 99.3454142393126 a6485 loss_cnaBRCA24 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 46 3.68887945411394 NA 3.06260317671282 3.48534049337189 -0.422737316659072 1.42493051241738 1.18861499237517 0.352392784233957 0.296672232768672 0.355655379892465 0.557097915015516 NA NA NA 0.661374969516991 99.3454142393126 a6486 gain_cnaBRCA8_(CHD4,WNK1) 167 OSU-03012 PDPK1 (PDK1) 3 45 2.77258872223978 NA 1.85505626946884 2.27417387812534 -0.419117608656499 0.862135765076549 1.20126536344971 0.35263396292353 0.486138756370101 0.348896772860333 0.557157573144059 NA NA NA 0.495242404746134 99.3454142393126 a6487 loss_cnaBRCA20 201 Epothilone B Microtubules 3 45 -3.44201937618241 NA -3.63723562048417 -4.27565941172566 0.638423791241493 1.71422703266436 1.81565875873946 0.352454175992966 0.372426626739874 0.351621023591859 0.55735784587943 NA NA NA 0.589694440101577 99.3454142393126 a6488 gain_cnaBRCA63 1170 CCT018159 HSP90 6 37 2.30258509299405 NA 3.6107683573928 3.29937868909947 0.311389668293335 1.67078023910386 1.11452565262005 0.260296005608875 0.186373803690874 0.279392105117825 0.557473575487287 NA NA NA 0.675400943859574 99.3454142393126 a6489 loss_cnaBRCA7_(FAS,PTEN) 308 XL-880 MET 4 45 1.63315443905142 NA 1.39190493541412 1.88824691743177 -0.496341982017658 1.39418764837462 1.62396782116895 0.308233157433317 0.356008018430163 0.305635355299334 0.557505687315052 NA NA NA 0.540223209427936 99.3454142393126 a6490 BRCA2_mut 286 KIN001-236 TIE2 6 43 2.32630161961136 NA 4.36617137550433 4.56437365822131 -0.198202282716982 0.545678649147897 0.792345314132691 0.257449024556965 0.363221619585967 0.2501463429918 0.557518798223646 NA NA NA 0.455928736386687 99.3454142393126 a6491 ASH1L_mut 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 40 1.6094379124341 NA 2.03744309497416 2.60708377038736 -0.569640675413201 1.57537359436978 1.61195477877122 0.353772419796509 0.361590848957376 0.353385022281725 0.557771117788733 NA NA NA 0.600082067047958 99.3454142393126 a6492 gain_cnaBRCA47_(EGFR) 268 YM155 BIRC5 (Survivin) 7 42 1.63315443905142 NA -3.92691432563713 -3.54035528136676 -0.38655904427037 1.57878203260117 1.60789681407124 0.240965444280287 0.244846366558582 0.240412842968196 0.557855578949035 NA NA NA 0.565849993088594 99.3454142393126 a6493 NF1_mut 151 QS11 ARFGAP 5 43 2.32630161961136 NA 4.13186337753907 3.71726227824588 0.414601099293189 0.974112349234936 1.52626194696946 0.278927165564127 0.425619385298641 0.271644785560184 0.557863486203161 NA NA NA 0.430764559699905 99.3454142393126 a6494 gain_cnaBRCA9_(KRAS) 254 AC220 FLT3 4 44 0.0237165266173161 NA 2.47422985563598 2.20099208279835 0.273237772837624 0.560195442611092 0.905000051829392 0.308182681104919 0.487754365804998 0.301920173689817 0.557994892950896 NA NA NA 0.42414056763109 99.3454142393126 a6495 loss_cnaBRCA17 1114 Cetuximab EGFR 9 36 4.18661983833127 NA 6.12755821998623 6.32134176391979 -0.193783543933556 1.19470232426894 0.792438531970859 0.219885681959989 0.162202366227198 0.24454078911534 0.55826844007726 NA NA NA 0.654228061937638 99.3454142393126 a6496 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 9 17 2.30258509299405 NA 2.88994964434992 2.58650358349159 0.303446060858328 1.4318196378699 1.13291950474625 0.244600036931672 0.211930366669479 0.267844325732827 0.558493720962342 NA NA NA 0.590673149241248 99.3454142393126 a6497 gain_cnaBRCA31 1067 CCT007093 PPM1D 14 32 1.88706964903238 NA 3.95561562252801 4.14252023700925 -0.186904614481239 1.3262158589555 0.807655938758244 0.188875375000678 0.140930764188297 0.231416133420131 0.558584562173766 NA NA NA 0.630873268276898 99.3454142393126 a6498 gain_cnaBRCA31 1036 PLX4720 BRAF 13 30 2.30258509299405 NA 4.4316985897455 4.66807975137696 -0.236381161631456 1.00717875915817 1.28115111777247 0.195774388014617 0.234696333180249 0.184506853525953 0.558697343533115 NA NA NA 0.521601756867751 99.3454142393126 a6499 loss_cnaBRCA38 193 GW-2580 CSF1R (cFMS) 4 44 2.99573227355399 NA 5.67443596683705 5.44420276759069 0.230233199246358 0.0597232938095269 0.774124303817431 0.307547202072486 3.85499835257968 0.297411149748189 0.558803990759733 NA NA NA 0.0622193368157467 99.3454142393126 a6500 loss_cnaBRCA34 228 KIN001-102 AKT1 5 44 2.32630161961136 NA 2.29593892311186 1.9036768542606 0.39226206885126 0.883763095235469 1.45139634080295 0.277806163239291 0.443854321328892 0.270265300954424 0.55891638873444 NA NA NA 0.414950770813109 99.3454142393126 a6501 ASH1L_mut 230 GSK429286A ROCK2 3 46 2.99573227355399 2.32630161961136 5.10902515849826 5.42483913563617 -0.315813977137913 0.416505766582211 0.915968240594613 0.350757697631789 0.758246349695082 0.344787038612713 0.558922217430221 NA NA NA 0.325435820799783 99.3454142393126 a6502 BRCA2_mut 173 FH535 unknown 6 42 3.46573590279973 NA 1.28418351644104 1.61425729216244 -0.330073775721407 1.03155723175235 1.31259760590707 0.25686064243905 0.319976212236616 0.251466080873513 0.559047721632563 NA NA NA 0.501241450470976 99.3454142393126 a6503 PIK3CA_mut 219 AT-7519 CDK9 17 32 2.32630161961136 NA 1.88175981991618 1.56056586644917 0.321193953467005 1.72298238828118 1.86640894030097 0.176591478733586 0.186417432732684 0.172091949696303 0.559082329686168 NA NA NA 0.55021500648942 99.3454142393126 a6504 loss_cnaBRCA22_(SYNCRIP,ZNF292) 164 JQ12 HDAC 17 30 1.63315443905142 NA 1.76576376368593 1.47141750229319 0.294346261392736 1.40988692251906 1.76544713517452 0.178625618617361 0.20877295667572 0.166726182579032 0.559199162541102 NA NA NA 0.534646789079874 99.3454142393126 a6505 loss_cnaBRCA60 176 IPA-3 PAK1, PAK2, PAK3 3 44 3.46573590279973 NA 4.9948557247308 4.46288379490863 0.531971929822172 0.625350476899284 1.54428847755645 0.351060869948311 0.850678058902078 0.344477043993697 0.559252736074853 NA NA NA 0.283676018405247 99.3454142393126 a6506 gain_cnaBRCA31 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 16 32 2.77258872223978 NA -0.266875781651871 -0.521352911481737 0.254477129829865 1.70853214458576 1.24547783049623 0.180065953160375 0.148944888532703 0.204320882796023 0.559346300056199 NA NA NA 0.601436749332022 99.3454142393126 a6507 BRCA1_mut 150 Bicalutamide ANDR (androgen receptor) 4 44 0.0237165266173161 NA 2.93873385046143 2.74657446099737 0.192159389464064 0.352077948802067 0.6405850340641 0.307043984171384 0.545786494490438 0.299974834324393 0.559445109809546 NA NA NA 0.382131107849139 99.3454142393126 a6508 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 305 TPCA-1 IKK 7 42 2.99573227355399 NA 4.46335696284165 4.13082126612804 0.332535696713609 1.50401034688768 1.368058349452 0.239897644219529 0.22109934110609 0.243071281898767 0.559595619586984 NA NA NA 0.59886958152256 99.3454142393126 a6509 loss_cnaBRCA17 3 Rapamycin MTOR 4 10 -2.30258509299405 NA -2.06029970649611 -3.01500910572356 0.954709399227446 0.971421724752195 3.05408378952142 0.355023766177722 0.982796014234691 0.312600918973821 0.559601944724608 NA NA NA 0.394721129082073 99.3454142393126 a6510 loss_cnaBRCA28_(GPS2) 1067 CCT007093 PPM1D 4 42 1.88706964903238 NA 3.80772085757231 4.1121043540333 -0.304383496460992 0.532556688446038 1.01498024922714 0.30758637896711 0.571551354183835 0.299891053735051 0.559659488822851 NA NA NA 0.366630212715384 99.3454142393126 a6511 loss_cnaBRCA7_(FAS,PTEN) 256 JW-7-24-1 LCK 4 44 2.32630161961136 NA 1.50900900135015 1.86743823112054 -0.358429229770387 0.487831173590391 1.20144976720302 0.306802627765168 0.734740314220558 0.298330599875858 0.559752737959318 NA NA NA 0.276255538092199 99.3454142393126 a6512 loss_cnaBRCA17 1022 AZD7762 CHEK1, CHEK2 8 37 0.693147180559945 NA 0.597835200018572 0.971110790612978 -0.373275590594406 1.20696418464966 1.69934595474396 0.229093083930107 0.309268158361099 0.219658386541219 0.559901250959349 NA NA NA 0.476509930701465 99.3454142393126 a6513 POLR2B_mut 1032 Afatinib ERBB2, EGFR 3 42 -0.693147180559945 NA -0.312258496464329 0.333523855170816 -0.645782351635145 2.47173012290157 1.80279467192697 0.351100237232754 0.261267338878025 0.358211815073139 0.559938547796378 NA NA NA 0.697579711946842 99.3454142393126 a6514 loss_cnaBRCA57 1161 ZG-10 IRAK1 5 21 2.30258509299405 NA 2.31091793771043 1.89552789663299 0.415390041077433 1.58188549843003 1.37562449369089 0.294165768572107 0.262591724552564 0.301964702564225 0.559944721707845 NA NA NA 0.609878458088879 99.3454142393126 a6515 gain_cnaBRCA31 60 BI-2536 PLK1, PLK2, PLK3 3 9 -1.36257783450257 NA -1.01529190324083 -1.65871062110476 0.643418717863934 0.678484253777264 1.75786376631773 0.40181222556873 0.948317833880281 0.36602308449177 0.560115183339091 NA NA NA 0.384342142552774 99.3454142393126 a6516 ASH1L_mut 271 VNLG/124 HDAC, RAR 3 46 1.63315443905142 NA 3.88348210949191 4.16891562711799 -0.285433517626086 0.88408672171496 0.813105140177 0.349688248729028 0.322856921855357 0.351041339578731 0.560117043112748 NA NA NA 0.635810876890055 99.3454142393126 a6517 gain_cnaBRCA48 1375 Temozolomide DNA akylating agent 5 41 3.40119738166216 NA 5.72644234676347 5.92130686086204 -0.194864514098565 0.541460234614848 0.71483526338646 0.278040880250741 0.359887027044887 0.272600589365742 0.560232088531388 NA NA NA 0.493094707455064 99.3454142393126 a6518 gain_cnaBRCA47_(EGFR) 258 STF-62247 stimulates autophagy 7 42 2.32630161961136 NA 4.43276516858274 4.66385586151534 -0.231090692932599 0.795132597001423 0.987335479215018 0.239488840911099 0.290631642827977 0.234054885899905 0.560262506421013 NA NA NA 0.509388356920133 99.3454142393126 a6519 loss_cnaBRCA36_(FAT1,IRF2) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 9 36 -0.669430653942629 NA -3.91338975998407 -3.37939192278423 -0.533997837199835 2.71704532742025 2.37341233328319 0.21876105668015 0.196536226985528 0.22499159952588 0.560274952519299 NA NA NA 0.599509878034641 99.3454142393126 a6520 gain_cnaBRCA12_(TERT) 192 LFM-A13 BTK 9 39 2.77258872223978 NA 4.94354055770426 4.76130002423688 0.182240533467381 0.811465027132587 0.845866568614541 0.216956914715175 0.224582116756591 0.21544832273709 0.560282339897986 NA NA NA 0.557782282934157 99.3454142393126 a6521 TP53_mut 196 Phenformin AAPK1 (AMPK) agonist 38 10 8.29404964010203 NA 7.28099787229841 6.90187088870818 0.379126983590231 1.79927832578679 1.89562111670791 0.208479955151077 0.210710582213258 0.200001456118327 0.560346174470384 NA NA NA 0.578882271892674 99.3454142393126 a6522 loss_cnaBRCA33 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 5 38 -1.38629436111989 0.693147180559945 -2.4565526403371 -2.1894530593828 -0.267099580954301 0.925855856140237 0.959795522691105 0.27923591387227 0.288489378970719 0.27828800472563 0.560444203204181 NA NA NA 0.571348386985302 99.3454142393126 a6523 gain_cnaBRCA48 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 5 42 2.99573227355399 NA 4.20303048046744 3.80535663121297 0.397673849254471 1.94410501010464 1.37320682678537 0.277474254612365 0.204553687783082 0.289595013291197 0.560456494175675 NA NA NA 0.677362080800877 99.3454142393126 a6524 MACF1_mut 1025 SB 216763 GSK3A, GSK3B 3 36 2.30258509299405 NA 5.14670423992278 4.86769942435452 0.27900481556826 0.504896301446428 0.803723535098104 0.352963263304006 0.55259825585762 0.347140283174865 0.560525276200199 NA NA NA 0.449921167536249 99.3454142393126 a6525 gain_cnaBRCA31 254 AC220 FLT3 16 32 0.0237165266173161 NA 2.11767049071214 2.27680760044616 -0.159137109734017 0.757291196326523 0.942898866518219 0.179480479363023 0.210139917783227 0.168774314388193 0.560619517177989 NA NA NA 0.532030645712201 99.3454142393126 a6526 gain_cnaBRCA10_(MDM2,NUP107) 268 YM155 BIRC5 (Survivin) 5 44 1.63315443905142 NA -3.9939899248884 -3.55030391982776 -0.443686005060631 1.12174660875228 1.6419882415417 0.276561566383789 0.39553139862321 0.270212656726484 0.560672498527789 NA NA NA 0.457194632727003 99.3454142393126 a6527 gain_cnaBRCA9_(KRAS) 299 OSI-027 MTORC1/2 4 44 2.99573227355399 NA 1.82758484633601 1.21818635611176 0.609398490224252 2.18961528460631 1.9780609111602 0.305839610641185 0.278313041797122 0.308078728408227 0.560981023676584 NA NA NA 0.623869112976881 99.3454142393126 a6528 loss_cnaBRCA20 1020 Lenalidomide TNFA 3 42 1.6094379124341 NA 4.02169948476672 4.27137136917825 -0.249671884411526 0.248093067879153 0.7283489629981 0.350063556332494 1.00636380752542 0.34279156983186 0.561093267319535 NA NA NA 0.227259663845064 99.3454142393126 a6529 gain_cnaBRCA47_(EGFR) 265 Tubastatin A HDAC6 7 42 2.99573227355399 NA 4.90451703648986 4.65629990278799 0.248217133701875 0.757935438316913 1.07392117461223 0.238912077744204 0.327491130713021 0.231131613352816 0.561204064201495 NA NA NA 0.469692674828056 99.3454142393126 a6530 gain_cnaBRCA19 1010 Gefitinib EGFR 4 41 -0.693147180559945 NA 1.69217391492069 1.37138307319167 0.320790841729018 0.901872778344079 1.05598398673661 0.306692457522042 0.355694117210212 0.303783812783357 0.56127932303787 NA NA NA 0.541967801257516 99.3454142393126 a6531 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1114 Cetuximab EGFR 6 39 4.18661983833127 NA 6.47867099671301 6.2524179871977 0.226253009515307 0.818148937671575 0.889328757967243 0.256712617392713 0.276542569570786 0.254408740849062 0.561342069494765 NA NA NA 0.553089957897314 99.3454142393126 a6532 loss_cnaBRCA24 1219 PFI-1 BRD2, BRD3, BRD4 3 44 2.30258509299405 NA 3.49992654838269 3.15015523384977 0.349771314532923 0.995018011944755 1.00217552357058 0.34912247119816 0.35152259590688 0.349012030633864 0.561415908945525 NA NA NA 0.60897177726195 99.3454142393126 a6533 TP53_mut 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 35 8 1.6094379124341 NA 3.01044368167007 2.66355685384853 0.346886827821542 1.31274831339512 2.23994174888255 0.229444603465537 0.264244733192154 0.154864218230048 0.561424499524573 NA NA NA 0.684115894265756 99.3454142393126 a6534 loss_cnaBRCA17 1378 Bleomycin (50 uM) DNA damage 10 38 3.91202300542815 NA 4.12419335913325 3.73075031160154 0.393443047531711 1.46997938996084 1.98264005986013 0.207809011932339 0.267652084252823 0.198444011849265 0.56160429523005 NA NA NA 0.494998126043906 99.3454142393126 a6535 gain_cnaBRCA14_(RAD21) 1042 BIRB 0796 p38, JNK2 19 24 2.30258509299405 NA 4.27353752251721 4.44026649668108 -0.166728974163878 1.04899472479945 0.820585429929242 0.179701070438664 0.158941670746489 0.203182957048427 0.561625333475195 NA NA NA 0.573396145521832 99.3454142393126 a6536 loss_cnaBRCA38 266 Zibotentan, ZD4054 Endothelin A Receptor 4 45 2.99573227355399 NA 5.60366237796138 5.75433956286225 -0.150677184900865 0.197314905356069 0.508289125089345 0.304817252424066 0.763638127737776 0.296439914732348 0.561864921095663 NA NA NA 0.263017697158143 99.3454142393126 a6537 loss_cnaBRCA20 203 BMS-345541 IKBKB 3 46 2.77258872223978 NA 3.20161003535908 3.55390097870339 -0.352290943344308 0.428207431149064 1.0303167529328 0.348106989555738 0.82271095202379 0.341924890905162 0.561886019481597 NA NA NA 0.295219256412465 99.3454142393126 a6538 MLL3_mut 1218 JQ1 BRD2, BRD3, BRD4 3 43 0 NA 2.2280060180355 2.47402669902861 -0.246020680993109 0.332685623013229 0.717828016063892 0.34901421599716 0.739498986354833 0.34272928262417 0.561892022679206 NA NA NA 0.336458637291628 99.3454142393126 a6539 loss_cnaBRCA28_(GPS2) 1529 MLN4924 NEDD8-activating enzyme 3 34 0 NA 0.922641134131923 0.320383578663066 0.602257555468857 1.60331920532104 1.71409774754281 0.352617838012407 0.375631722909639 0.351355432519647 0.561989024080569 NA NA NA 0.588549508376367 99.3454142393126 a6540 loss_cnaBRCA60 1529 MLN4924 NEDD8-activating enzyme 3 34 0 NA 0.922641134131923 0.320383578663066 0.602257555468857 1.60331920532104 1.71409774754281 0.352617838012407 0.375631722909639 0.351355432519647 0.561989024080569 NA NA NA 0.588549508376367 99.3454142393126 a6541 loss_cnaBRCA17 283 GSK2126458 PI3K, MTOR 10 38 -2.05572501506252 0.0237165266173161 -3.32490257295136 -2.98442509639016 -0.3404774765612 0.49776005882616 1.81248343806813 0.207560539630912 0.684019279015937 0.187851358754541 0.562070576384725 NA NA NA 0.312664575575829 99.3454142393126 a6542 loss_cnaBRCA29_(MAP2K4) 1059 AZD8055 MTORC1/2 5 38 0.693147180559945 NA -0.118274221072724 0.163155069796909 -0.281429290869634 1.26406100979776 0.980969570632289 0.278070182928291 0.222639009263217 0.286888910007919 0.562075494802034 NA NA NA 0.653443143724304 99.3454142393126 a6543 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1495 AZD-2281 PARP1, PARP2 9 36 2.30258509299405 NA 4.19633078802038 3.94928142418906 0.247049363831322 1.34862361761792 1.07968521679939 0.217749530962964 0.183186294978052 0.228816103052401 0.562082762258157 NA NA NA 0.620263996935404 99.3454142393126 a6544 PTEN_mut 292 Masitinib KIT 9 39 2.99573227355399 NA 3.81843448743178 4.05461035691931 -0.236175869487525 1.13896905694421 1.08397831299096 0.215934090214637 0.207359337856966 0.217878777330755 0.562126029888731 NA NA NA 0.582351313302715 99.3454142393126 a6545 gain_cnaBRCA15 207 AS601245 JNK 22 26 2.07944154167984 NA 2.14815859073858 2.3660825090375 -0.217923918298914 1.51201742716583 1.0649325164351 0.169139368976747 0.144127914390112 0.204636364216224 0.562154776372641 NA NA NA 0.573911178749303 99.3454142393126 a6546 gain_cnaBRCA10_(MDM2,NUP107) 184 BMS-754807 IGF1R 4 44 0.940007258491471 NA 2.09774590706847 1.58406195900819 0.513683948060288 1.37107810872854 1.704853634435 0.304838469080123 0.374656954107925 0.301306773604953 0.562259362389175 NA NA NA 0.5225451494588 99.3454142393126 a6547 CDH1_mut 206 Ruxolitinib JAK1, JAK2, TYK2 4 45 1.65632149833295 0.0237165266173161 4.18688707306885 4.38656030826531 -0.199673235196459 0.43443914505586 0.668334996797976 0.304425288519594 0.459611518595511 0.298762201819601 0.562366214505103 NA NA NA 0.446567261342476 99.3454142393126 a6548 loss_cnaBRCA18 106 XMD8-85 MAP2K5 (ERK5) 5 8 2.07944154167984 NA 2.96428939072698 3.38640915004391 -0.422119759316931 0.873273873634283 1.40680416808559 0.340514654924431 0.483376145859265 0.30005580655292 0.562399058178048 NA NA NA 0.518225968645604 99.3454142393126 a6549 loss_cnaBRCA18 87 GW843682X PLK1 5 7 -1.36257783450257 NA -1.51297884689074 -2.20164752219496 0.688668675304227 1.92781770513121 1.99055774924303 0.350342350569446 0.35722707259676 0.345967694514823 0.562929827249918 NA NA NA 0.562209756385319 99.3454142393126 a6550 gain_cnaBRCA8_(CHD4,WNK1) 273 CUDC-101 HDAC, EGFR 4 45 1.63315443905142 NA -0.466154485444321 0.0124186864074817 -0.478573171851802 1.43330362645794 1.58379984655605 0.303928631641387 0.333895179651835 0.302167709444127 0.563001722687108 NA NA NA 0.563149619933766 99.3454142393126 a6551 PIK3CA_mut 1268 XAV 939 TNKS1 (tankyrase-1) 16 31 1.6094379124341 NA 3.54987821184811 3.7190243497261 -0.16914613787799 1.10407646335908 0.851101495033088 0.179370734275302 0.153201470633088 0.198737916529467 0.563005297157634 NA NA NA 0.596741220363735 99.3454142393126 a6552 gain_cnaBRCA13_(FGFR1,WHSC1L1) 274 PXD101, Belinostat HDAC 11 37 2.99573227355399 NA 0.903078172406795 0.602656775942889 0.300421396463907 1.7944896370189 1.40940529317062 0.200074999654415 0.167413280225447 0.213154724137635 0.563008660829064 NA NA NA 0.617785582707171 99.3454142393126 a6553 CDH1_mut 154 CHIR-99021 GSK3B 4 43 0.940007258491471 NA 3.52889021800821 3.25185980262816 0.277030415380046 0.564259930086107 0.929358537275459 0.304566473146717 0.490962410422748 0.298087771585118 0.563046587546192 NA NA NA 0.42296470023964 99.3454142393126 a6554 loss_cnaBRCA7_(FAS,PTEN) 222 BX-912 PDPK1 (PDK1) 4 45 2.32630161961136 NA 4.30729517891873 3.84613505550991 0.461160123408827 0.720996206919265 1.55705061388164 0.303892533487814 0.639615186575407 0.296175422492646 0.563047926807076 NA NA NA 0.323898525831324 99.3454142393126 a6555 gain_cnaBRCA14_(RAD21) 1005 Cisplatin DNA crosslinker 20 25 1.79175946922805 2.30258509299405 3.78538344748027 3.57784363487085 0.207539812609416 1.30578273094015 1.08487189782944 0.174761272327141 0.158939008528616 0.191303519820775 0.563247052466922 NA NA NA 0.571786052710025 99.3454142393126 a6556 POLR2B_mut 179 5-Fluorouracil DNA antimetabolite 3 46 3.46573590279973 NA 3.51250282219997 4.07597498365313 -0.563472161453156 0.945173900319657 1.64812490895284 0.346875741247947 0.596157131785579 0.341886806268321 0.563265361230501 NA NA NA 0.418045877188191 99.3454142393126 a6557 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1072 BMS-708163 g-secretase 14 32 1.6094379124341 NA 3.55978651292413 3.73870244340638 -0.178915930482244 1.12950016835755 0.877410024930498 0.186601179416797 0.158402747953914 0.203913706703335 0.563311973146583 NA NA NA 0.603821785057373 99.3454142393126 a6558 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1203 QL-XII-61 BTK 8 15 2.30258509299405 NA 4.48047330924493 4.08907116010957 0.391402149135366 1.53662890611154 1.51550837829887 0.257064892813284 0.254714816035717 0.258264589453941 0.563344887428755 NA NA NA 0.567974715198708 99.3454142393126 a6559 gain_cnaBRCA12_(TERT) 287 KIN001-244 PDPK1 (PDK1) 9 40 2.99573227355399 NA 3.3122605880274 3.51542126896889 -0.203160680941485 1.25478538267086 0.869684754772443 0.214674540795386 0.161908708650279 0.233602670193572 0.563428000526368 NA NA NA 0.654563237294887 99.3454142393126 a6560 loss_cnaBRCA28_(GPS2) 1001 AICAR AAPK1 (AMPK) agonist 3 42 7.60090245954208 NA 8.18869919529564 7.70632501715716 0.482374178138484 2.58590915329204 1.29999690655094 0.347905524797152 0.18653949135235 0.371057943067176 0.56350083671179 NA NA NA 0.77821392445246 99.3454142393126 a6561 gain_cnaBRCA13_(FGFR1,WHSC1L1) 269 NSC-207895 MDM4 11 38 2.99573227355399 NA 4.41975436241264 4.65725998917672 -0.237505626764073 1.18555216378216 1.19433941892243 0.199170283922737 0.200333341728617 0.198859405459763 0.563534603519436 NA NA NA 0.567093593307734 99.3454142393126 a6562 gain_cnaBRCA9_(KRAS) 226 GSK1070916 AURKB 4 45 0.940007258491471 2.32630161961136 2.94883615679569 2.3555131805349 0.593322976260786 0.287062241922499 2.01946204246573 0.303444386991252 2.06687919765139 0.293802489863264 0.563621692657329 NA NA NA 0.0832983339612849 99.3454142393126 a6563 gain_cnaBRCA14_(RAD21) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 19 24 0.693147180559945 NA 2.81264262912434 2.98424141115946 -0.171598782035125 1.18780971290322 0.733871530339431 0.178754632574686 0.144466559054907 0.233826732528726 0.563679663555312 NA NA NA 0.585367725712762 99.3454142393126 a6564 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 258 STF-62247 stimulates autophagy 9 40 2.32630161961136 NA 4.79973244140003 4.59284275977808 0.206889681621943 0.596478953393956 1.02433401959733 0.214393772574597 0.346851603807216 0.201974822337026 0.563936523847622 NA NA NA 0.429151165050285 99.3454142393126 a6565 loss_cnaBRCA20 268 YM155 BIRC5 (Survivin) 3 46 1.63315443905142 NA -4.11711459661601 -3.56156474580469 -0.555549850811326 2.28072318200324 1.56757340541828 0.346268407972482 0.243584953752856 0.354401171193057 0.563946364188139 NA NA NA 0.715969461786567 99.3454142393126 a6566 PIK3CA_mut 1059 AZD8055 MTORC1/2 15 28 0.693147180559945 NA 0.00785950057597027 0.196093894224264 -0.188234393648293 1.0550126114407 0.989158057918001 0.185979052943232 0.178419093390027 0.190297589087525 0.564261563560499 NA NA NA 0.573522216770243 99.3454142393126 a6567 PTEN_mut 206 Ruxolitinib JAK1, JAK2, TYK2 9 40 1.65632149833295 0.0237165266173161 4.25558579232724 4.39606225083173 -0.140476458504495 0.587918638730661 0.669022557363756 0.214165029728204 0.238938603490764 0.209972678736027 0.564350988185901 NA NA NA 0.53901810026782 99.3454142393126 a6568 gain_cnaBRCA62 1008 Methotrexate Dihydrofolate reductase (DHFR) 8 37 -1.6094379124341 NA 0.479075325881589 0.72666623630084 -0.247590910419251 1.62611067151811 0.956988476557055 0.226283087619173 0.152259569262961 0.25871880015735 0.56470619947109 NA NA NA 0.688674973216412 99.3454142393126 a6569 gain_cnaBRCA15 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 19 23 -1.38629436111989 0.693147180559945 -0.134338656666197 -0.440937244064945 0.306598587398749 1.23368808121211 2.0076455579803 0.179986709402943 0.248521966020383 0.152715496109377 0.564785325183627 NA NA NA 0.547708350393162 99.3454142393126 a6570 gain_cnaBRCA63 170 Shikonin unknown 6 41 2.77258872223978 NA 0.267101885167452 -0.0349520726049336 0.302053957772385 1.41414721511819 1.160574574449 0.253524880725769 0.213594422520672 0.260262428991941 0.564797565530498 NA NA NA 0.635350979436255 99.3454142393126 a6571 loss_cnaBRCA42 158 PF-562271 FAK 3 42 0.940007258491471 NA 2.75209449175413 2.30333275653941 0.448761735214718 0.648834621043442 1.31771728162997 0.346723096865069 0.691642709344069 0.340559952784116 0.564822174020178 NA NA NA 0.3625728294066 99.3454142393126 a6572 gain_cnaBRCA10_(MDM2,NUP107) 1049 PD-173074 FGFR1, FGFR3 3 40 0.693147180559945 NA 2.56682985114086 2.96558405030609 -0.398754199165234 1.07355818774113 1.15144251597179 0.347417708139126 0.371432311465343 0.346308385902093 0.564838475895235 NA NA NA 0.591413207831619 99.3454142393126 a6573 PTEN_mut 184 BMS-754807 IGF1R 8 40 0.940007258491471 NA 1.31149318218151 1.68994410917955 -0.378450926998042 1.51529610851993 1.71389508029262 0.224575434729892 0.249753777410341 0.220813357450928 0.564844377730077 NA NA NA 0.541436932563456 99.3454142393126 a6574 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1030 KU-55933 ATM 4 38 2.30258509299405 NA 4.47793174299817 4.19539068263207 0.282541060366095 0.308531759143194 0.959258042091535 0.304973049793484 0.915760053845751 0.294541247472945 0.565051128784517 NA NA NA 0.223089376954568 99.3454142393126 a6575 gain_cnaBRCA31 9 MG-132 Proteasome 4 10 0 NA 0.732317292054746 0.167858902984599 0.564458389070146 1.51170519711079 1.64482911355416 0.350034617056319 0.373391842635028 0.343171448279184 0.565054210893869 NA NA NA 0.560799772878413 99.3454142393126 a6576 loss_cnaBRCA38 186 Bexarotene Retinioic acid X family agonist 4 43 2.07944154167984 NA 3.92170257391093 3.57488945184001 0.346813122070918 0.706612773236344 1.16973570237973 0.302971605767055 0.490810717279402 0.296488447232444 0.565084986808013 NA NA NA 0.423378460482174 99.3454142393126 a6577 gain_cnaBRCA8_(CHD4,WNK1) 305 TPCA-1 IKK 4 45 2.99573227355399 NA 4.56309511455227 4.14412469909022 0.418970415462049 1.87376335688997 1.34665324199163 0.302222101400394 0.223598360978436 0.311119746641247 0.565188072383333 NA NA NA 0.689113268875031 99.3454142393126 a6578 gain_cnaBRCA16 263 FR-180204 ERK 16 33 2.99573227355399 NA 5.27045788842977 5.40027373831031 -0.129815849880533 0.892461225872924 0.649758213916081 0.176388762470461 0.145458251985747 0.199791010102258 0.565343865967434 NA NA NA 0.608751237721714 99.3454142393126 a6579 loss_cnaBRCA18 167 OSU-03012 PDPK1 (PDK1) 16 32 2.77258872223978 NA 2.10749282607491 2.31822212833901 -0.210729302264097 0.750306123020457 1.35070148327582 0.177274022862281 0.280857766981533 0.156014711520876 0.565430837686695 NA NA NA 0.491214719862014 99.3454142393126 a6580 gain_cnaBRCA16 302 PI-103 PI3Ka, PRKDC (DNAPK) 16 32 2.32630161961136 NA 0.90848697506526 1.23840625157448 -0.329919276509218 1.86505054626648 1.8594509934126 0.177254089538553 0.176895622035371 0.177428325714423 0.565474396832877 NA NA NA 0.567362854011557 99.3454142393126 a6581 loss_cnaBRCA23 207 AS601245 JNK 3 45 2.07944154167984 NA 2.68312553038459 2.23840572533489 0.444719805049704 0.562755562526074 1.31199417039823 0.345142729544474 0.790253948008021 0.33896477216413 0.565532930446156 NA NA NA 0.311023331533044 99.3454142393126 a6582 gain_cnaBRCA16 17 Cyclopamine SMO 3 10 2.77258872223978 NA 4.44470036966655 4.77092229982772 -0.326221930161173 0.391826208873248 0.906922597971536 0.389666117766859 0.832567916013763 0.359702063760255 0.565854912921638 NA NA NA 0.396014144060774 99.3454142393126 a6583 loss_cnaBRCA57 1052 RO-3306 CDK1 5 38 1.6094379124341 NA 3.23206728156238 3.56430573948009 -0.332238457917705 1.10748282604004 1.21675552166897 0.27536680997252 0.299994230254271 0.273052763682541 0.565867651181195 NA NA NA 0.558762091244913 99.3454142393126 a6584 gain_cnaBRCA8_(CHD4,WNK1) 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 3 23 2.30258509299405 NA 2.2992443158146 2.74271194656794 -0.443467630753337 1.45707565179009 1.21936578699492 0.357371372647329 0.304354568143743 0.363687119552736 0.56587461660132 NA NA NA 0.656738860770228 99.3454142393126 a6585 loss_cnaBRCA34 238 CAL-101 PI3Kdelta 5 44 2.99573227355399 2.32630161961136 4.9515361791751 4.69253558764304 0.259000591532065 0.552016519398067 0.977893404897669 0.272885676844007 0.469189928979816 0.264855648105294 0.565875177094528 NA NA NA 0.396555597211799 99.3454142393126 a6586 gain_cnaBRCA12_(TERT) 170 Shikonin unknown 9 38 2.77258872223978 NA -0.202935594618413 0.0525262285728459 -0.255461823191259 0.862834000588517 1.25119613592579 0.21441394169578 0.296072967705277 0.204174082588767 0.565887691888093 NA NA NA 0.477870144948755 99.3454142393126 a6587 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1 Erlotinib EGFR 3 9 0.693147180559945 NA 3.09872802411247 2.86918745138019 0.229540572732283 0.271507165869528 0.634031619942387 0.395794845179551 0.845430992574936 0.362033320598649 0.565904344599865 NA NA NA 0.406463241526294 99.3454142393126 a6588 CDH1_mut 184 BMS-754807 IGF1R 4 44 0.940007258491471 NA 2.09296397518313 1.58449668008867 0.508467295094454 1.00312877073819 1.72276771178814 0.301720140082455 0.506881379466643 0.295145591373252 0.56625038648401 NA NA NA 0.410881156170632 99.3454142393126 a6589 gain_cnaBRCA62 62 BMS-536924 IGF1R 4 8 1.63315443905142 NA 2.90661309250678 3.29350040032623 -0.386887307819443 1.20417073468201 1.00053557404728 0.363029193811834 0.321289412436691 0.386680211933333 0.566462860505393 NA NA NA 0.602690837580829 99.3454142393126 a6590 MACF1_mut 1042 BIRB 0796 p38, JNK2 3 40 2.30258509299405 NA 4.06801054965102 4.3889894299805 -0.32097888032948 0.667631277483053 0.93931400957505 0.345916506418392 0.480772682699288 0.341716270658725 0.566514528996946 NA NA NA 0.500858672916563 99.3454142393126 a6591 loss_cnaBRCA28_(GPS2) 230 GSK429286A ROCK2 4 45 2.99573227355399 2.32630161961136 5.15650185428412 5.42763707328049 -0.271135218996376 0.442619427282694 0.923493411561789 0.301092548533562 0.612569630440569 0.293597350670687 0.566637531301687 NA NA NA 0.340216164425199 99.3454142393126 a6592 loss_cnaBRCA36_(FAT1,IRF2) 135 Gemcitabine DNA replication 9 38 0.0237165266173161 NA -0.755192728307039 -0.161546861651774 -0.593645866655265 3.04303892695314 2.71301969490376 0.213960348061716 0.195083231238733 0.218813695960406 0.566706783849766 NA NA NA 0.601836365704609 99.3454142393126 a6593 loss_cnaBRCA34 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 40 2.30258509299405 NA 3.49521897992433 3.13707297800535 0.358146001918979 1.0128442204127 1.33437678242937 0.273852587767297 0.353604231234145 0.268399455562272 0.566726005009251 NA NA NA 0.500926251047761 99.3454142393126 a6594 gain_cnaBRCA16 1036 PLX4720 BRAF 14 29 2.30258509299405 NA 4.74966790812072 4.52272839635552 0.226939511765202 1.01007408276479 1.28909260720678 0.187922430742168 0.22467610607731 0.176045933780457 0.566799478386406 NA NA NA 0.533789449749201 99.3454142393126 a6595 loss_cnaBRCA60 254 AC220 FLT3 3 45 0.0237165266173161 NA 2.50959747416034 2.2047061920709 0.304891282089438 0.496360556000899 0.900493439662179 0.343825932390233 0.614253647682845 0.338582457862011 0.567011569784595 NA NA NA 0.407095817979592 99.3454142393126 a6596 loss_cnaBRCA60 277 ABT-869 VEGFR and PDGFR family 3 45 0.0237165266173161 NA 2.53725282989743 2.70133327579319 -0.16408044589576 0.44728664296016 0.478642816016912 0.343751868932877 0.366835112289224 0.342803527818879 0.56709479289547 NA NA NA 0.595010166513323 99.3454142393126 a6597 BRCA1_mut 201 Epothilone B Microtubules 4 44 -3.44201937618241 NA -3.73579034662235 -4.28120952278677 0.545419176164418 0.83202556413549 1.86090156993709 0.301053771042878 0.655531752478221 0.293094049129561 0.567105062963507 NA NA NA 0.317118493352566 99.3454142393126 a6598 POLR2B_mut 1026 17-AAG HSP90 3 40 0 NA -1.47268878571223 -0.852970490064372 -0.619718295647862 2.27764309101938 1.76600284643576 0.345372257504047 0.27208753561582 0.35091579659603 0.567122779301831 NA NA NA 0.686676437284952 99.3454142393126 a6599 gain_cnaBRCA10_(MDM2,NUP107) 279 BIX02189 MAP2K5 (MEK5) 5 44 2.99573227355399 NA 5.24798655302995 5.0022843958538 0.245702157176152 1.13243649702643 0.879178980697081 0.271944592012443 0.216967713263676 0.279467733613627 0.56721098089765 NA NA NA 0.660376223902823 99.3454142393126 a6600 loss_cnaBRCA28_(GPS2) 1025 SB 216763 GSK3A, GSK3B 3 36 2.30258509299405 NA 5.14233561650519 4.86806347630599 0.274272140199199 0.396015443207756 0.807331379906796 0.346921651519441 0.692579405433216 0.339726842069316 0.567224934266011 NA NA NA 0.365585145750262 99.3454142393126 a6601 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 204 Tipifarnib Farnesyl-transferase (FNTA) 6 42 2.77258872223978 NA 1.28544781619163 1.66776634340271 -0.382318527211076 1.44451301521597 1.52902381796965 0.251514512332935 0.264669492890595 0.250040923311938 0.567226978065498 NA NA NA 0.567005919108444 99.3454142393126 a6602 BRCA1_mut 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 3 23 2.30258509299405 NA 5.00089261258365 4.6446916612324 0.356200951351254 0.463594221197408 1.03549111688645 0.356058853079491 0.768346400934916 0.343992281094879 0.567292398928494 NA NA NA 0.345644135732384 99.3454142393126 a6603 loss_cnaBRCA7_(FAS,PTEN) 346 THZ-2-102-1 CDK7 4 44 0.916290731874155 2.99573227355399 -2.03963635417208 -1.2711141190885 -0.768522235083576 1.3136898678678 2.61941246464022 0.300829038893673 0.585010400004788 0.293394891204785 0.567393445473861 NA NA NA 0.357959256389423 99.3454142393126 a6604 gain_cnaBRCA61_(NOTCH2) 153 Midostaurin KIT 3 44 -0.669430653942629 NA 1.08246868062745 0.5801192043629 0.502349476264553 0.898324257393303 1.48245347487461 0.34373166350855 0.559207293057227 0.338863569601767 0.567453732112964 NA NA NA 0.443320157017847 99.3454142393126 a6605 loss_cnaBRCA17 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 10 37 2.77258872223978 NA 4.84463259145129 5.05583902115057 -0.211206429699286 1.0867958816795 1.01395198696234 0.205267345340698 0.194338636407873 0.208300227639014 0.567529968043388 NA NA NA 0.589311677206086 99.3454142393126 a6606 gain_cnaBRCA10_(MDM2,NUP107) 303 PIK-93 PI4K, PI3K 5 44 2.99573227355399 NA 3.13980737613065 2.75194990688769 0.387857469242958 1.34260172108426 1.435102910941 0.271710887000374 0.28888497843555 0.270264568684235 0.567542950290998 NA NA NA 0.569426665740092 99.3454142393126 a6607 CDH1_mut 1013 Nilotinib ABL 4 36 0.693147180559945 NA 3.46611744708094 3.17366181966385 0.292455627417086 0.980827805822385 0.960662872532158 0.303922563583172 0.29817224356917 0.304431071272921 0.567574666486241 NA NA NA 0.60364249717912 99.3454142393126 a6608 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1018 ABT-888 PARP1, PARP2 15 30 1.6094379124341 NA 4.48405000722035 4.36258928442273 0.121460722797621 0.559913200311164 0.713246458964045 0.182044340875033 0.216927771536946 0.170292780666639 0.567835752473077 NA NA NA 0.536527045660043 99.3454142393126 a6609 loss_cnaBRCA36_(FAT1,IRF2) 136 Mitomycin C DNA crosslinker 9 39 2.77258872223978 NA -0.390938961582075 -0.0750821297479503 -0.315856831834125 1.71032092225031 1.43242148498805 0.212770766915346 0.184676938535339 0.220505511223018 0.567847159421959 NA NA NA 0.617667786839056 99.3454142393126 a6610 gain_cnaBRCA61_(NOTCH2) 134 Etoposide TOP2 3 44 2.77258872223978 NA 3.17383182679296 2.42959736988012 0.744234456912837 1.33285059255102 2.19898436015047 0.343305285165117 0.558378006561415 0.338444633986351 0.567932653761645 NA NA NA 0.443915609997339 99.3454142393126 a6611 BRCA2_mut 230 GSK429286A ROCK2 6 43 2.99573227355399 2.32630161961136 5.20743756079542 5.43314070581363 -0.225703145018213 0.513194727344723 0.936020999859038 0.2506347419686 0.439800202519625 0.241130428753418 0.56795811069706 NA NA NA 0.393341352321987 99.3454142393126 a6612 ASH1L_mut 1038 NU-7441 PRKDC (DNAPK) 3 40 0.693147180559945 NA 2.58864089620906 2.9156818246327 -0.327040928423635 1.61191006562753 0.9019780089719 0.344612275459491 0.202890307218421 0.362581931234006 0.567972674578564 NA NA NA 0.760131775487072 99.3454142393126 a6613 loss_cnaBRCA22_(SYNCRIP,ZNF292) 268 YM155 BIRC5 (Survivin) 19 30 1.63315443905142 NA -3.42997143469422 -3.70046216125578 0.270490726561556 1.55166591965337 1.63645314854871 0.168581419796078 0.174322786326313 0.165290846732423 0.568050465154574 NA NA NA 0.563819051919672 99.3454142393126 a6614 loss_cnaBRCA36_(FAT1,IRF2) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 9 39 0.246860077931526 2.32630161961136 0.0218632290381411 -0.331139971456035 0.353003200494176 1.85476044652198 1.61596188440996 0.212657448260941 0.190322799451606 0.21844772695432 0.568052638429469 NA NA NA 0.608881697065344 99.3454142393126 a6615 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 265 Tubastatin A HDAC6 7 42 2.99573227355399 NA 4.48274680667856 4.72659494108987 -0.243848134411316 1.75931830271557 0.885851728600778 0.234677029503476 0.138603761488145 0.275269694169338 0.568141826850382 NA NA NA 0.730800726457302 99.3454142393126 a6616 POLR2B_mut 309 Y-39983 ROCK 3 46 2.99573227355399 NA 5.28451627353065 4.91218514379917 0.372331129731473 0.152377803882568 1.11103937898446 0.342342730792217 2.44347352596323 0.335119651719097 0.568358075212501 NA NA NA 0.055768726245227 99.3454142393126 a6617 TP53_mut 235 QL-XII-47 BTK, BMX 38 11 2.32630161961136 NA 1.64141751724929 1.93834672643066 -0.296929209181369 1.50157113660157 1.54102893840136 0.196634989420866 0.197745682467893 0.192682435600073 0.568492717106812 NA NA NA 0.579286852226416 99.3454142393126 a6618 PIK3CA_mut 286 KIN001-236 TIE2 17 32 2.32630161961136 NA 4.45343155312172 4.58614872354603 -0.132717170424319 0.724514737186391 0.792493812607054 0.172354131040609 0.183180774127132 0.167467768597109 0.56851737926418 NA NA NA 0.55856558377851 99.3454142393126 a6619 loss_cnaBRCA57 271 VNLG/124 HDAC, RAR 5 44 1.63315443905142 NA 4.35010479565374 4.12886457267352 0.221240222980225 0.598250177840703 0.833772508775041 0.271002299286036 0.36981221431268 0.265348426161551 0.568550059682763 NA NA NA 0.482793734830075 99.3454142393126 a6620 loss_cnaBRCA60 1241 CHIR-99021 GSK3B 3 43 2.30258509299405 NA 4.54628503203555 4.20952444554169 0.336760586493861 0.9527792651988 0.983098548507298 0.343023959421139 0.353450792638309 0.342550181774947 0.568599342650865 NA NA NA 0.607487831374601 99.3454142393126 a6621 gain_cnaBRCA48 1033 Vismodegib SMO 5 40 2.30258509299405 NA 4.95010132830663 4.73598372485379 0.214117603452839 0.928493161040682 0.769588875179192 0.272508723441887 0.230607625814766 0.278223361015949 0.568623864855245 NA NA NA 0.642907387553618 99.3454142393126 a6622 gain_cnaBRCA14_(RAD21) 204 Tipifarnib Farnesyl-transferase (FNTA) 21 27 2.77258872223978 NA 1.76276686402753 1.50891737686983 0.253849487157705 1.74723793214218 1.31904591853956 0.166994187563108 0.145286158506458 0.19244931779082 0.56879918663317 NA NA NA 0.582856543941422 99.3454142393126 a6623 gain_cnaBRCA9_(KRAS) 1192 GSK269962A ROCK1, ROCK2 4 42 1.6094379124341 NA 3.07104333072618 2.6295531911958 0.441490139530381 0.801309615098106 1.50708867126827 0.30037978098466 0.550960741281418 0.29294237820715 0.568860036670864 NA NA NA 0.381863033613025 99.3454142393126 a6624 PIK3CA_mut 261 TL-1-85 MAP3K7 (TAK1) 17 32 2.32630161961136 NA 4.16163176841911 3.95211802400211 0.209513744416997 1.30420309301748 1.16895111255253 0.172200697087751 0.160645029550003 0.179232255452926 0.568860490508027 NA NA NA 0.583368091361114 99.3454142393126 a6625 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 294 MPS-1-IN-1 MPS1 9 40 2.99573227355399 NA 4.95977598906743 4.71078458857871 0.248991400488717 0.512551975804747 1.2710321607603 0.211553016650989 0.485787612266602 0.195897010457845 0.569094455414581 NA NA NA 0.352131914096555 99.3454142393126 a6626 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 328 SNX-2112 HSP90 9 39 0.940007258491471 NA 0.770033005533494 0.335826176273062 0.434206829260432 1.93085092786639 2.07187136967336 0.212010528650625 0.224878483881837 0.209572290836225 0.569226391100002 NA NA NA 0.559341401727774 99.3454142393126 a6627 gain_cnaBRCA10_(MDM2,NUP107) 305 TPCA-1 IKK 5 44 2.99573227355399 NA 4.51504992644114 4.14006232466053 0.374987601780604 1.55325729046605 1.36984911393151 0.270475132168364 0.241420145961839 0.2737437269309 0.569299889201768 NA NA NA 0.628094686400595 99.3454142393126 a6628 gain_cnaBRCA64_(SDHC) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 8 40 0.246860077931526 2.32630161961136 -0.572045977289099 -0.203533050178232 -0.368512927110867 1.58337539062944 1.6733818714618 0.221995728701973 0.232738824470659 0.220220460969227 0.569307363860129 NA NA NA 0.56448237259239 99.3454142393126 a6629 loss_cnaBRCA18 127 GSK269962A ROCK1, ROCK2 6 8 0.916290731874155 NA 2.67093401469579 2.31593042609108 0.355003588604713 0.558666496383219 1.39325408074558 0.315963231248708 0.635448144649786 0.254801757633998 0.569351899435701 NA NA NA 0.528319664206664 99.3454142393126 a6630 MACF1_mut 1072 BMS-708163 g-secretase 3 43 1.6094379124341 NA 3.3773676714993 3.70566014780102 -0.328292476301724 1.24616228787834 0.943069878041495 0.342353851656601 0.263442795127961 0.34811044647455 0.56935212098086 NA NA NA 0.695409930869831 99.3454142393126 a6631 loss_cnaBRCA33 292 Masitinib KIT 6 42 2.99573227355399 NA 3.77091554461136 4.04452907235883 -0.273613527747473 1.08663946963146 1.09476877064281 0.25012936276934 0.251797891935833 0.249928144723034 0.569355793991325 NA NA NA 0.583630468014325 99.3454142393126 a6632 gain_cnaBRCA58_(CCND1) 1218 JQ1 BRD2, BRD3, BRD4 9 37 0 NA 2.57881312198801 2.42859048687688 0.150222635111128 0.309608202989489 0.765624476950918 0.213080445609636 0.485202374034734 0.196209290107059 0.56935598351417 NA NA NA 0.362709637971555 99.3454142393126 a6633 ARID1A_mut 228 KIN001-102 AKT1 5 44 2.32630161961136 NA 1.60082157637592 1.98266746184422 -0.381845885468305 1.79121789537969 1.37170927598164 0.270377034703562 0.213176680767453 0.278372314129788 0.569439474379894 NA NA NA 0.66562731719474 99.3454142393126 a6634 PTEN_mut 1192 GSK269962A ROCK1, ROCK2 8 38 1.6094379124341 NA 2.39724181104422 2.72493349644143 -0.327691685397207 1.67853366738456 1.42686705975722 0.222951333581092 0.195224970320558 0.22965817534043 0.569461252517587 NA NA NA 0.619012012002968 99.3454142393126 a6635 gain_cnaBRCA47_(EGFR) 257 NPK76-II-72-1 PLK3 7 42 2.32630161961136 NA 3.16010717787247 3.53210248360112 -0.371995305728658 1.29214247729087 1.63008981088923 0.233819639563106 0.287890315709294 0.228205405152328 0.569551522489526 NA NA NA 0.51444560974076 99.3454142393126 a6636 gain_cnaBRCA64_(SDHC) 134 Etoposide TOP2 8 39 2.77258872223978 NA 2.87701523059425 2.39506815154744 0.481947079046804 2.47504233001761 2.10646698093065 0.222308468944351 0.194722762193476 0.228794034470873 0.569647808554627 NA NA NA 0.619438852568767 99.3454142393126 a6637 gain_cnaBRCA48 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 5 43 2.32630161961136 NA 5.1278455660308 4.93879794271513 0.189047623315673 0.338019151373285 0.723682537135289 0.27059004573475 0.559280805681043 0.261230047175135 0.56965154733053 NA NA NA 0.338423837590004 99.3454142393126 a6638 gain_cnaBRCA64_(SDHC) 1069 EHT 1864 Rac GTPases 9 37 2.30258509299405 NA 3.41374250667146 3.5973436569146 -0.18360115024314 0.610114760573164 0.908962211907612 0.21290443845871 0.300928877823999 0.201989860346143 0.569673804977049 NA NA NA 0.476365588014945 99.3454142393126 a6639 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1039 SL 0101-1 RSK, AURKB, PIM3 4 39 2.30258509299405 NA 4.91316253680011 4.62171716144871 0.291445375351395 0.341797955630729 1.00153144430934 0.300888219217309 0.852683202313434 0.290999725477792 0.569704562452816 NA NA NA 0.242028858902816 99.3454142393126 a6640 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1009 ATRA Retinoic acid and retinoid X receptor agonist 6 39 2.30258509299405 NA 3.85289875484806 4.14490504339162 -0.292006288543565 1.17805264110274 1.16024445851867 0.251225117277695 0.247872020617199 0.25167652075355 0.569708759559422 NA NA NA 0.589914639730502 99.3454142393126 a6641 gain_cnaBRCA64_(SDHC) 1047 Nutlin-3a MDM2 7 36 2.07944154167984 1.38629436111989 4.00690956099031 4.2458402638774 -0.238930702887092 1.42162699797548 0.920720593638197 0.236642964319061 0.168068489995865 0.259504028190535 0.569858201891582 NA NA NA 0.681788849492535 99.3454142393126 a6642 TP53_mut 83 JW-7-52-1 MTOR 9 3 0.182321556793955 NA -1.80212964495224 -2.67327235111743 0.871142706165189 2.26841529216803 2.03692624182685 0.391692777583425 0.384031402527091 0.427675135347017 0.569869799963308 NA NA NA 0.568394299445501 99.3454142393126 a6643 gain_cnaBRCA16 304 SB52334 ALK5 16 33 2.99573227355399 NA 4.45193372748198 4.22914412131827 0.222789606163712 1.27673851445482 1.27915872990496 0.1742740170151 0.174499009500661 0.174168850944921 0.569998693520966 NA NA NA 0.571300582343284 99.3529259713874 a6644 gain_cnaBRCA58_(CCND1) 1054 PD-0332991 CDK4, CDK6 8 34 1.38629436111989 0.693147180559945 2.61489198146279 2.94596656345759 -0.331074581994804 1.33975757241059 1.49892609236689 0.224866787128779 0.247115290715701 0.220874520552256 0.570355693208803 NA NA NA 0.550949595236869 99.3647909440408 a6645 loss_cnaBRCA18 1143 HG-5-88-01 EGFR, ADCK4 7 19 2.30258509299405 NA 4.71734966477951 4.46655555671594 0.250794108063571 0.844288785973131 1.02865970564984 0.2544053948335 0.297047778236809 0.243806680368739 0.570380700065104 NA NA NA 0.538363947118059 99.3647909440408 a6646 gain_cnaBRCA64_(SDHC) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 7 36 0.693147180559945 NA 3.0983652841699 2.87148463422223 0.226880649947665 1.09221964069292 0.935582970962988 0.236308668259405 0.207724382070011 0.242501902011041 0.570401176675312 NA NA NA 0.621391185947415 99.3647909440408 a6647 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1192 GSK269962A ROCK1, ROCK2 8 38 1.6094379124341 NA 2.39790732262125 2.724793388741 -0.326886066119751 1.37110720382628 1.48775545269462 0.222399138010923 0.238410290025118 0.219717605825403 0.570414310955894 NA NA NA 0.558570209456222 99.3647909440408 a6648 PTEN_mut 1001 AICAR AAPK1 (AMPK) agonist 7 38 7.60090245954208 NA 7.46314503343207 7.78920350190692 -0.326058468474849 0.811854712035025 1.45872914946136 0.235132212484513 0.401621698613461 0.223522282114707 0.570520847973317 NA NA NA 0.413826169581305 99.3647909440408 a6649 loss_cnaBRCA33 1378 Bleomycin (50 uM) DNA damage 5 43 3.91202300542815 NA 3.35495110370157 3.86594627706239 -0.510995173360823 1.35791347343684 1.93691959292593 0.269852036505463 0.376309082542284 0.263818475081306 0.570700924557744 NA NA NA 0.477504372612864 99.3647909440408 a6650 gain_cnaBRCA12_(TERT) 1013 Nilotinib ABL 9 31 0.693147180559945 NA 3.041467367341 3.2497770641985 -0.208309696857497 0.992443259554127 0.954154500989368 0.216461215226633 0.209895825128667 0.218318623075718 0.570905848432117 NA NA NA 0.585860061221842 99.3647909440408 a6651 gain_cnaBRCA64_(SDHC) 265 Tubastatin A HDAC6 8 41 2.99573227355399 NA 4.88350813040691 4.65434512510413 0.229163005302777 1.5676185369741 0.915812655670629 0.220532825289524 0.146185439823338 0.250229131344517 0.571006279568939 NA NA NA 0.699425768021746 99.3647909440408 a6652 loss_cnaBRCA22_(SYNCRIP,ZNF292) 127 GSK269962A ROCK1, ROCK2 4 10 0.916290731874155 NA 2.19156487130675 2.57867880116764 -0.387113929860891 0.558370721250326 1.25685839629647 0.344497647588549 0.693291956630624 0.308001228301917 0.57113875220599 NA NA NA 0.441455131283823 99.3647909440408 a6653 gain_cnaBRCA8_(CHD4,WNK1) 1001 AICAR AAPK1 (AMPK) agonist 3 42 7.60090245954208 NA 7.29706692405504 7.77001303653149 -0.472946112476451 0.562180939527283 1.41470195794323 0.341053645751972 0.841270273008782 0.334307950746066 0.571179008499057 NA NA NA 0.290581864312728 99.3647909440408 a6654 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 263 FR-180204 ERK 9 40 2.99573227355399 NA 5.4842702435191 5.32944818468612 0.154822058832982 0.490778970050622 0.776841444827138 0.210343572621876 0.315461884638237 0.199296857632812 0.571297468050115 NA NA NA 0.45876403402139 99.3647909440408 a6655 CDH1_mut 225 Genentech Cpd 10 AURKA, AURKB 4 45 2.32630161961136 NA 2.57572694001653 3.05738224749832 -0.48165530748179 1.5103914284729 1.62735445955304 0.297292208355415 0.318894359701692 0.295974429328739 0.571527649382755 NA NA NA 0.579444759516164 99.3647909440408 a6656 gain_cnaBRCA27_(CLTC,PPM1D) 150 Bicalutamide ANDR (androgen receptor) 9 39 0.0237165266173161 NA 2.6554205804161 2.78731862723038 -0.131898046814277 0.536880240563912 0.643165378479624 0.210706932984337 0.245674988291127 0.20507640993685 0.571595225592648 NA NA NA 0.533372082215357 99.3647909440408 a6657 PTEN_mut 1026 17-AAG HSP90 6 37 0 NA -1.28369430657456 -0.833370814061194 -0.45032349251337 2.05802400428627 1.754792477374 0.250944073077114 0.218813527721482 0.256624927630911 0.571660795585085 NA NA NA 0.629625723378987 99.3647909440408 a6658 loss_cnaBRCA36_(FAT1,IRF2) 1133 JNJ-26854165 MDM2 9 34 2.30258509299405 NA 3.11687625708299 2.92962330184415 0.187252955238832 0.8455546420787 0.883587878464676 0.213686781116161 0.221455771064649 0.211923408868174 0.571762274745301 NA NA NA 0.568438158041256 99.3647909440408 a6659 loss_cnaBRCA29_(MAP2K4) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 5 38 -1.38629436111989 0.693147180559945 -1.99124112303393 -2.25067825902795 0.259437135994021 0.91205084646014 0.961473979320963 0.271160883993869 0.284454684737096 0.269832716822194 0.571792724601381 NA NA NA 0.577150128759346 99.3647909440408 a6660 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1164 XMD8-92 MAP2K5 (ERK5) 13 13 2.30258509299405 NA 4.03197206359876 3.73700590989446 0.294966153704292 1.26576322617233 1.35709999751563 0.224782951936445 0.233034225995228 0.217350345769855 0.571917241401099 NA NA NA 0.571942846695165 99.3647909440408 a6661 MLL3_mut 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 3 42 2.30258509299405 NA 1.71695891257843 1.34020723695597 0.376751675622461 0.26766854503646 1.1322034963748 0.340315533411827 1.40753062923827 0.332759682185033 0.572009198685292 NA NA NA 0.138556246396736 99.3647909440408 a6662 loss_cnaBRCA24 1133 JNJ-26854165 MDM2 3 40 2.30258509299405 NA 3.24677184517953 2.94796907602274 0.298802769156788 1.07460489323232 0.864907278047957 0.3409817274377 0.278058262193479 0.345473759720427 0.572041449403374 NA NA NA 0.680693020012358 99.3647909440408 a6663 loss_cnaBRCA60 171 AKT inhibitor VIII AKT1, AKT2, AKT3 3 44 0.940007258491471 NA 2.28861271179418 1.86138911018841 0.427223601605767 1.51431724556574 1.2453525406063 0.339463006545973 0.282122918996513 0.34305434619965 0.572257417443768 NA NA NA 0.676326417316069 99.3647909440408 a6664 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1495 AZD-2281 PARP1, PARP2 8 37 2.30258509299405 NA 4.2056898007314 3.95393486370644 0.251754937024963 0.777051630246783 1.19194476631657 0.221851865935918 0.323987399582455 0.211213593229619 0.572324841998078 NA NA NA 0.467043988806101 99.3647909440408 a6665 CDH1_mut 1028 VX-702 p38 4 41 0.693147180559945 NA 3.24040789889142 3.44501909355249 -0.204611194661078 1.23957496768448 0.625904856600405 0.297941202084047 0.16506560715992 0.326904628560355 0.572462688320623 NA NA NA 0.764815019922221 99.3647909440408 a6666 gain_cnaBRCA47_(EGFR) 1053 MK-2206 AKT1, AKT2 6 36 1.38629436111989 0.693147180559945 1.74921962163664 1.33465562471289 0.414563996923752 1.54849450463808 1.66676865465956 0.250878784475853 0.267720676878117 0.248723178087619 0.57257805949564 NA NA NA 0.566973253587063 99.3647909440408 a6667 loss_cnaBRCA7_(FAS,PTEN) 1007 Docetaxel Microtubules 4 41 -4.38202663467388 NA -4.16665353505706 -4.62831635020716 0.461662815150096 1.35570028916467 1.56372757139344 0.297823877081656 0.340534570096282 0.295232253747824 0.572613361141397 NA NA NA 0.55805268612153 99.3647909440408 a6668 MLL3_mut 1028 VX-702 p38 3 42 0.693147180559945 NA 3.64461757173679 3.41127527895256 0.233342292784233 0.797872142020824 0.680868082699372 0.339776499295728 0.292455746347067 0.342712925915287 0.572615850935811 NA NA NA 0.666107235376842 99.3647909440408 a6669 gain_cnaBRCA9_(KRAS) 163 JQ1 BRD4 4 43 0.940007258491471 NA 0.713774653565807 0.27890670653951 0.434867947026297 1.5891927819984 1.45497294468427 0.296979333108212 0.273640776595684 0.298883871768944 0.572776319608567 NA NA NA 0.629860029704292 99.3647909440408 a6670 loss_cnaBRCA20 166 FTI-277 Farnesyl transferase (FNTA) 3 44 0.0237165266173161 NA 2.50404979190462 2.22668369732582 0.277366094578802 0.298561512594314 0.834780919098474 0.338894707462331 0.929008203933128 0.332262139961638 0.572898449721448 NA NA NA 0.254567595189011 99.3647909440408 a6671 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 91 KIN001-135 IKKE 4 10 1.6094379124341 NA 3.80412035838527 3.66316556092819 0.140954797457078 0.405469802904343 0.413016936230701 0.342836310192565 0.347633279833497 0.341280913909895 0.572971234010536 NA NA NA 0.581347856659121 99.3647909440408 a6672 gain_cnaBRCA62 276 CAY10603 HDAC6 10 39 2.99573227355399 NA 1.01608073153037 1.21642667202431 -0.200345940493945 1.38274775646211 0.879490787415717 0.201201634275062 0.144889723781978 0.227797656735711 0.572987508076561 NA NA NA 0.671234019995322 99.3647909440408 a6673 gain_cnaBRCA13_(FGFR1,WHSC1L1) 230 GSK429286A ROCK2 11 38 2.99573227355399 2.32630161961136 5.54119167501081 5.36622545499052 0.174966220020287 0.947789572515057 0.887427988873624 0.194275288288562 0.184604499874372 0.197161034150348 0.57312669295565 NA NA NA 0.592326238019465 99.3647909440408 a6674 loss_cnaBRCA36_(FAT1,IRF2) 1046 681640 WEE1, CHEK1 8 28 0.693147180559945 NA 2.44368128116778 2.68811305572471 -0.244431774556932 0.968014937715129 1.09768569846172 0.227956993903837 0.252508267211125 0.222679201249935 0.573347917618473 NA NA NA 0.552174505808 99.3647909440408 a6675 gain_cnaBRCA16 54 CGP-082996 CDK4 3 9 1.63315443905142 NA 2.50640840324512 2.90998086864911 -0.403572465403994 1.11727467785253 1.01971515996142 0.388065562277643 0.361211502778961 0.39576980047964 0.573388943029538 NA NA NA 0.616230945711084 99.3647909440408 a6676 MACF1_mut 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 39 1.38629436111989 0.693147180559945 3.76468731841052 3.40794844155021 0.356738876860315 0.579767599676806 1.06810398015801 0.340042850637821 0.615313579198252 0.333992648176015 0.573514394584661 NA NA NA 0.409205676306585 99.3647909440408 a6677 gain_cnaBRCA63 221 TAK-715 p38a 7 42 2.99573227355399 2.32630161961136 4.2817258024124 4.51555719914282 -0.233831396730425 1.49325475740961 0.919025318030239 0.23136411354702 0.156591764111341 0.254434118563349 0.573598334024573 NA NA NA 0.700189219815013 99.3647909440408 a6678 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1009 ATRA Retinoic acid and retinoid X receptor agonist 7 38 2.30258509299405 NA 3.8771445925063 4.14812308088994 -0.270978488383633 0.969349803702748 1.19078559704839 0.233115284244923 0.279546648019674 0.227562786328042 0.573818581414177 NA NA NA 0.528193278730698 99.3647909440408 a6679 loss_cnaBRCA60 326 GSK690693 AKT 3 45 2.32630161961136 NA 3.55301322146155 2.89868258577923 0.654330635682318 1.19163118447825 1.96485111216406 0.337691232775278 0.549104995073467 0.333017922646387 0.573925376261274 NA NA NA 0.450399501241169 99.3647909440408 a6680 loss_cnaBRCA24 219 AT-7519 CDK9 3 46 2.32630161961136 NA 1.09587933939456 1.70957362275576 -0.613694283361194 1.61104986364888 1.82805508888881 0.337315468222395 0.380928174359069 0.335708856418671 0.574032516822176 NA NA NA 0.582473043753632 99.3647909440408 a6681 loss_cnaBRCA7_(FAS,PTEN) 1133 JNJ-26854165 MDM2 4 39 2.30258509299405 NA 3.20526969469128 2.94456409737649 0.260705597314788 0.801802987826745 0.88195341406749 0.297494562264224 0.325149196589327 0.295600190618274 0.574047993185094 NA NA NA 0.574564841372981 99.3647909440408 a6682 POLR2B_mut 261 TL-1-85 MAP3K7 (TAK1) 3 46 2.32630161961136 NA 3.63951476614732 4.04993418549458 -0.410419419347253 0.921336276805979 1.22827973435936 0.337294997578072 0.445461043572565 0.334141651829269 0.574055679247819 NA NA NA 0.527774007537188 99.3647909440408 a6683 loss_cnaBRCA20 286 KIN001-236 TIE2 3 46 2.32630161961136 NA 4.78381914276449 4.52420952452715 0.259609618237339 0.830582471803391 0.767306807802175 0.337109244381571 0.312563323993179 0.338338739598764 0.574265878886448 NA NA NA 0.646054929726376 99.3647909440408 a6684 loss_cnaBRCA29_(MAP2K4) 156 AZD6482 PI3Kbeta 7 40 1.63315443905142 NA 1.76369629818076 2.10399216510734 -0.340295866926577 1.29553023307356 1.49271077400648 0.231816889874975 0.262669182269292 0.227971736288345 0.574329710722843 NA NA NA 0.546779622152054 99.3647909440408 a6685 loss_cnaBRCA29_(MAP2K4) 151 QS11 ARFGAP 7 41 2.32630161961136 NA 4.05426626255878 3.71028612230139 0.343980140257395 2.03738996677674 1.38555293773246 0.231345095076126 0.168833726417918 0.248261997712148 0.574351866187563 NA NA NA 0.680136510553598 99.3647909440408 a6686 gain_cnaBRCA62 211 TL-2-105 CRAF 10 39 2.32630161961136 1.63315443905142 3.73320931771713 3.95225743364854 -0.219048115931409 0.951010535827262 1.12361916721521 0.200468821264582 0.230331954988137 0.194948717788697 0.57438100224984 NA NA NA 0.540692883039266 99.3647909440408 a6687 gain_cnaBRCA16 277 ABT-869 VEGFR and PDGFR family 16 32 0.0237165266173161 NA 2.74619588020065 2.66351943178674 0.082676448413912 0.508445935277509 0.461607764930053 0.173185637910144 0.162606174378771 0.179105410903215 0.574399633001813 NA NA NA 0.588534823768799 99.3647909440408 a6688 BRCA2_mut 193 GW-2580 CSF1R (cFMS) 6 42 2.99573227355399 NA 5.6251194348519 5.44028450076731 0.184834934084592 0.474795073592084 0.77565222079522 0.246832067165321 0.389294127856498 0.238296145010833 0.574439152880326 NA NA NA 0.437274657720195 99.3647909440408 a6689 gain_cnaBRCA15 223 ZSTK474 PI3K 22 27 1.63315443905142 2.32630161961136 0.782279107394083 1.01831184231942 -0.236032734925333 1.50359405770872 1.41172843241913 0.162390058640079 0.156979028824453 0.16719414974229 0.574492075276378 NA NA NA 0.577185558781189 99.3647909440408 a6690 loss_cnaBRCA33 52 GNF-2 ABL [T315I] 4 8 0.246860077931526 NA 2.62328371747568 2.41861483614077 0.204668881334908 0.381037843506133 0.641543648560857 0.35538912643173 0.537135312995789 0.319025652882748 0.574523590955325 NA NA NA 0.506269947218359 99.3647909440408 a6691 MACF1_mut 1262 UNC1215 LMBL3 3 43 0 NA 2.94582569342369 2.74438272494494 0.201442968478744 0.334363147641992 0.606204065177415 0.337684952362635 0.602467616121476 0.332302239543361 0.574610633559511 NA NA NA 0.415745349634898 99.3647909440408 a6692 gain_cnaBRCA64_(SDHC) 1377 Afatinib (rescreen) ERBB2, EGFR 9 38 2.30258509299405 NA 2.49642490633683 2.91474373560777 -0.418318829270944 2.46297252762293 1.88042190946798 0.20953144671349 0.169843075624832 0.22246009109163 0.57473515234005 NA NA NA 0.642873098823217 99.3647909440408 a6693 gain_cnaBRCA9_(KRAS) 312 AV-951 VEGFR 4 44 -2.05572501506252 NA 0.80654709851348 0.616433007498975 0.190114091014505 0.14054734204906 0.665323793032225 0.295087578999216 1.35266941546389 0.285746719124619 0.574785542986206 NA NA NA 0.135204961289665 99.3647909440408 a6694 PTEN_mut 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 8 40 2.77258872223978 NA -0.694188097213254 -0.384995022403487 -0.309193074809767 1.33430298559589 1.42743061921628 0.218718931017364 0.23172628566943 0.216608128372311 0.575001299123382 NA NA NA 0.56690181149829 99.3647909440408 a6695 gain_cnaBRCA8_(CHD4,WNK1) 1175 AG-014699 PARP1, PARP2 3 40 1.6094379124341 NA 3.53712425558583 3.88590412802551 -0.348779872439684 0.90325429570975 1.03731632783831 0.338233363545091 0.386136965078724 0.336232895481859 0.575131078727393 NA NA NA 0.578748437185869 99.3647909440408 a6696 gain_cnaBRCA62 1046 681640 WEE1, CHEK1 7 29 0.693147180559945 NA 2.83964544434983 2.58410681721329 0.255538627136544 1.32944006753635 1.0087318635776 0.238304454265319 0.192215229085201 0.253326613705096 0.575187406876397 NA NA NA 0.646846354632524 99.3647909440408 a6697 gain_cnaBRCA14_(RAD21) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 21 26 -2.30258509299405 NA -0.236028213556475 -0.0635338774581887 -0.172494336098286 1.25687256969456 0.829964114682568 0.165615832513669 0.137240910699646 0.207833487071016 0.575229978542518 NA NA NA 0.59221695443685 99.3647909440408 a6698 BRCA1_mut 1013 Nilotinib ABL 3 37 0.693147180559945 NA 2.90097702233964 3.22738822241091 -0.326411200071269 0.582111962102702 0.979245315979849 0.339150480175974 0.560736114908562 0.333329345307775 0.575415898950521 NA NA NA 0.445273833246912 99.3647909440408 a6699 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 254 AC220 FLT3 9 39 0.0237165266173161 NA 2.37400987214182 2.18908928759988 0.184920584541941 0.457626078611551 0.952943591297302 0.208502136541286 0.404086640129852 0.194051973517338 0.575612668563213 NA NA NA 0.399115233836772 99.3647909440408 a6700 gain_cnaBRCA62 1024 CEP-701 FLT3, JAK2, NTRK1, RET 8 37 0.693147180559945 NA 0.886346717305965 0.569184534258352 0.317162183047613 1.77774352703165 1.36723214284917 0.219939139764927 0.178407165164701 0.231973907800821 0.575628959878578 NA NA NA 0.64615831305448 99.3647909440408 a6701 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 305 TPCA-1 IKK 6 43 2.99573227355399 NA 3.87943449608236 4.220032207925 -0.34059771184264 0.796726430143343 1.44078364823488 0.245642116144213 0.427496439124482 0.236397541199132 0.57566749098722 NA NA NA 0.405220061048713 99.3647909440408 a6702 ARID1A_mut 1036 PLX4720 BRAF 4 39 2.30258509299405 NA 4.92101610229475 4.56334384099542 0.357672261299331 0.828122280494301 1.23285412539303 0.296123806519049 0.431907545206777 0.290117260373611 0.575806978863924 NA NA NA 0.474533327111651 99.3647909440408 a6703 loss_cnaBRCA60 290 KIN001-260 IKK 3 46 2.99573227355399 NA 4.71435632205354 5.06557693803058 -0.351220615977045 0.616864431091479 1.06118470519971 0.335733592142055 0.569364350211595 0.330970295987206 0.575823746353671 NA NA NA 0.436486696880618 99.3647909440408 a6704 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1175 AG-014699 PARP1, PARP2 17 26 1.6094379124341 NA 3.75188867241376 3.93328578679785 -0.181397114384095 1.08682221393304 0.993962712849969 0.175909454581687 0.166905968665884 0.182498912724783 0.575837892580099 NA NA NA 0.583882027917886 99.3647909440408 a6705 gain_cnaBRCA19 254 AC220 FLT3 4 44 0.0237165266173161 NA 1.9845216320099 2.24551101221891 -0.260989380209012 0.744111512318007 0.896017319207375 0.294270206997125 0.350739608094484 0.291277160177981 0.575841719766573 NA NA NA 0.547113606676627 99.3647909440408 a6706 gain_cnaBRCA64_(SDHC) 207 AS601245 JNK 8 40 2.07944154167984 NA 2.50047780675174 2.21934529443025 0.281132512321496 1.55889356093295 1.23402767238399 0.218142318026611 0.1803410568668 0.227817024377081 0.576006123039762 NA NA NA 0.642307930627997 99.3647909440408 a6707 gain_cnaBRCA64_(SDHC) 166 FTI-277 Farnesyl transferase (FNTA) 8 39 0.0237165266173161 NA 2.39288004104928 2.21392799306809 0.178952047981189 1.23504805055124 0.715786234077361 0.218636676380022 0.144894806239577 0.250007669135822 0.576016692981718 NA NA NA 0.702187913783706 99.3647909440408 a6708 gain_cnaBRCA8_(CHD4,WNK1) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 3 40 -1.38629436111989 0.693147180559945 -1.92018335986935 -2.24303573446559 0.322852374596245 0.532022820335371 0.973649801156663 0.337412492478064 0.606839335186277 0.331589832620216 0.576055461823537 NA NA NA 0.414266791793141 99.3647909440408 a6709 loss_cnaBRCA7_(FAS,PTEN) 1175 AG-014699 PARP1, PARP2 4 39 1.6094379124341 NA 4.13824021873204 3.83319428238077 0.305045936351271 0.396721518585687 1.06531991184492 0.295815443593629 0.768917041452049 0.28634209589023 0.576203040694924 NA NA NA 0.274585405366078 99.3647909440408 a6710 POLR2B_mut 1039 SL 0101-1 RSK, AURKB, PIM3 3 40 2.30258509299405 NA 4.34491988856268 4.67162149445031 -0.326701605887631 1.42520950492597 0.939377943240465 0.337241633452708 0.229230583123707 0.347785050988791 0.576247957605624 NA NA NA 0.731609802100678 99.3647909440408 a6711 gain_cnaBRCA27_(CLTC,PPM1D) 134 Etoposide TOP2 9 38 2.77258872223978 NA 2.84283831196743 2.39047986703677 0.45235844493066 2.95079947183616 1.95827917982998 0.208633983225813 0.153300300223104 0.230997934099434 0.576368757464488 NA NA NA 0.671197644454703 99.3647909440408 a6712 loss_cnaBRCA60 205 BMS-708163 g-secretase 3 45 2.32630161961136 0.940007258491471 5.11095656776786 4.88223438094307 0.228722186824791 0.526737634891952 0.688049054820994 0.335453610045707 0.434224121600325 0.332421337144771 0.576457406395962 NA NA NA 0.537195704203316 99.3647909440408 a6713 MLL3_mut 229 LY317615 PRKCB (PKCbeta) 3 46 2.99573227355399 2.32630161961136 2.84886446240368 3.39182559002316 -0.542961127619485 1.37314860193416 1.63054792142029 0.335072687190851 0.395413232664471 0.332993051284588 0.576572924853008 NA NA NA 0.569838223360262 99.3647909440408 a6714 BRCA1_mut 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 4 43 2.99573227355399 NA 3.46200322942126 3.88353762780458 -0.421534398383318 1.79948184787374 1.40385250240283 0.294033212839561 0.234253209545516 0.300269720402836 0.576576533863177 NA NA NA 0.676503348564489 99.3647909440408 a6715 MACF1_mut 1032 Afatinib ERBB2, EGFR 3 42 -0.693147180559945 NA 0.867749413818877 0.249237575864873 0.618511837954005 1.51974041416615 1.85412545822171 0.336162226084746 0.406985187857474 0.333586832116106 0.576691657738088 NA NA NA 0.560477920339443 99.3647909440408 a6716 PIK3CA_mut 229 LY317615 PRKCB (PKCbeta) 17 32 2.99573227355399 2.32630161961136 3.18005137731428 3.45342803481043 -0.273376657496148 1.86190970426106 1.48046643921541 0.168706077640261 0.146825948041688 0.184655761356554 0.576702733395525 NA NA NA 0.604711501059666 99.3647909440408 a6717 MLL3_mut 1022 AZD7762 CHEK1, CHEK2 3 42 0.693147180559945 NA 1.41601348075031 0.868231914537568 0.547781566212738 0.555527520092354 1.66467170922901 0.336081535924696 0.986056579378231 0.329062819519196 0.576782813211857 NA NA NA 0.237108245258948 99.3647909440408 a6718 gain_cnaBRCA15 5 Sunitinib PDGFRA, PDGFRB, KDR, KIT, FLT3 6 6 2.07944154167984 NA 3.01894392569972 3.49186355679331 -0.472919631093595 1.47674004098311 1.36128270026599 0.332998574186694 0.320245688454929 0.34740736145489 0.576846554638366 NA NA NA 0.576929073470107 99.3647909440408 a6719 gain_cnaBRCA62 282 EKB-569 EGFR 9 38 0.916290731874155 2.99573227355399 1.93603269190086 1.49328621104595 0.442746480854906 1.88503422858172 2.17317977981937 0.208369748466459 0.234874504739377 0.203732100292092 0.576850161074149 NA NA NA 0.54906561518911 99.3647909440408 a6720 PIK3CA_mut 63 BMS-509744 ITK 4 8 2.32630161961136 NA 3.8557524938788 3.46637178216096 0.389380711717839 1.45551918074637 0.910709990545902 0.353088371344693 0.267520151481734 0.427557307770868 0.576963276025002 NA NA NA 0.648984531683479 99.3647909440408 a6721 ARID1A_mut 150 Bicalutamide ANDR (androgen receptor) 5 43 0.0237165266173161 NA 2.61372739020343 2.77989708685378 -0.166169696650355 0.764869406464691 0.611175738840737 0.265429809945516 0.217252377001728 0.271885295979748 0.577008744281161 NA NA NA 0.660585207723519 99.3647909440408 a6722 BRCA2_mut 1018 ABT-888 PARP1, PARP2 5 40 1.6094379124341 NA 4.24496930235563 4.42283955323022 -0.177870250874586 0.635208351511302 0.670531550027941 0.266542345267389 0.280018753612722 0.265267534193096 0.577087595308957 NA NA NA 0.582088074775596 99.3647909440408 a6723 gain_cnaBRCA9_(KRAS) 178 BAY 61-3606 SYK 4 44 2.07944154167984 NA 2.66210228678736 3.1351755975579 -0.473073310770538 2.43054093798997 1.54007587301517 0.293251027028903 0.194637046994882 0.307175327566395 0.57715998952982 NA NA NA 0.726032066232912 99.3647909440408 a6724 gain_cnaBRCA48 309 Y-39983 ROCK 5 44 2.99573227355399 NA 4.67617735857665 4.96439042369252 -0.288213065115867 1.15037218531086 1.08176074954323 0.264958086539913 0.25053897233962 0.266429582731268 0.577176298384835 NA NA NA 0.616923884540378 99.3647909440408 a6725 gain_cnaBRCA31 1161 ZG-10 IRAK1 10 16 2.30258509299405 NA 2.17347811939516 1.85161839524334 0.321859724151828 1.6335118919097 1.26228323348672 0.227789465018419 0.197035433746092 0.25498217485055 0.577266536197086 NA NA NA 0.602386283135525 99.3647909440408 a6726 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1170 CCT018159 HSP90 5 38 2.30258509299405 NA 3.62551272543812 3.30563310562754 0.31987961981058 1.93166256818995 1.08800284492974 0.267282511474926 0.165598083784541 0.29400623472748 0.577283328215681 NA NA NA 0.733744537338334 99.3647909440408 a6727 gain_cnaBRCA12_(TERT) 238 CAL-101 PI3Kdelta 9 40 2.99573227355399 2.32630161961136 4.55852082894175 4.75506398229233 -0.196543153350582 0.966330026973729 0.945783640581219 0.207037402524698 0.203391334082932 0.20780984668946 0.577340970772636 NA NA NA 0.590374246119958 99.3647909440408 a6728 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1529 MLN4924 NEDD8-activating enzyme 6 31 0 NA 0.0101890854309423 0.438704211753366 -0.428515126322424 0.959535815549988 1.8034492115474 0.250798448258678 0.446585858889287 0.237608646574942 0.577484730821783 NA NA NA 0.414279851664716 99.3647909440408 a6729 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 228 KIN001-102 AKT1 9 40 2.32630161961136 NA 2.18226334969108 1.89002765139515 0.29223569829593 1.09864499848364 1.46858637258026 0.206895933854168 0.265996476295142 0.198991154863082 0.577600259941666 NA NA NA 0.510459086521869 99.3647909440408 a6730 loss_cnaBRCA33 281 CH5424802 ALK 6 42 1.63315443905142 NA 3.34618758172361 3.60796134666498 -0.261773764941371 0.816932714261131 1.09622566482572 0.244784055237945 0.320434915105745 0.238795508389223 0.577607654395914 NA NA NA 0.504156169895397 99.3647909440408 a6731 gain_cnaBRCA27_(CLTC,PPM1D) 135 Gemcitabine DNA replication 9 38 0.0237165266173161 NA -0.741701883502364 -0.164742061737091 -0.576959821765273 3.66552156281966 2.54192967669807 0.207903759693668 0.157401835421602 0.226977098168481 0.577699613043579 NA NA NA 0.664208600721637 99.3647909440408 a6732 gain_cnaBRCA19 192 LFM-A13 BTK 4 44 2.77258872223978 NA 4.5700114644121 4.81596636606655 -0.245954901654448 0.601034872765922 0.854451462858868 0.292713813300742 0.40921902005882 0.28785122660042 0.5778554452268 NA NA NA 0.491928296703864 99.3647909440408 a6733 gain_cnaBRCA48 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 5 38 1.6094379124341 NA 2.58922625431208 2.9928382215179 -0.403611967205818 0.817363786546943 1.56917313893001 0.266874094078742 0.493797222055712 0.257213150794203 0.577863019467 NA NA NA 0.389557288210115 99.3647909440408 a6734 gain_cnaBRCA12_(TERT) 1192 GSK269962A ROCK1, ROCK2 10 36 1.6094379124341 NA 2.89850881820399 2.60389775475245 0.294611063451541 1.58854540035787 1.43797036837703 0.200412268736024 0.185459643385181 0.204879787463252 0.577875897933475 NA NA NA 0.605251453200403 99.3647909440408 a6735 POLR2B_mut 1170 CCT018159 HSP90 3 40 2.30258509299405 NA 2.96919131723975 3.37085119223295 -0.401659874993198 1.88038762677524 1.15085500633804 0.335610389323305 0.21360482768227 0.349009973264363 0.578087357422769 NA NA NA 0.748492614609097 99.3863921543911 a6736 gain_cnaBRCA13_(FGFR1,WHSC1L1) 268 YM155 BIRC5 (Survivin) 11 38 1.63315443905142 NA -3.834123476137 -3.52652536471991 -0.307598111417093 1.21246973811505 1.69532374481844 0.191673511649337 0.253695495852373 0.181439157185896 0.57825739957464 NA NA NA 0.50816187604404 99.4001803783016 a6737 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1239 YK 4-279 RNA helicase A 6 36 2.30258509299405 NA 2.28894336199889 1.96765446650778 0.321288895491108 0.848648369181843 1.35308928414841 0.246997749507035 0.378588950569543 0.23744840732614 0.578508952242314 NA NA NA 0.45524146585225 99.4001803783016 a6738 TP53_mut 255 CP724714 ERBB2 37 11 2.32630161961136 NA 3.87681766830454 3.55485992393382 0.321957744370719 1.73146708094067 1.45657307248572 0.192150671027211 0.185945056602408 0.221037825326044 0.578518752863731 NA NA NA 0.545649028647758 99.4001803783016 a6739 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1050 ZM-447439 AURKB 4 35 1.38629436111989 0.693147180559945 3.23935962616356 2.84776001931856 0.391599606844996 0.762904782228167 1.36230007113178 0.295803733431086 0.513300763040542 0.287454735666027 0.578551951608881 NA NA NA 0.416078979417355 99.4001803783016 a6740 POLR2B_mut 1043 JNK Inhibitor VIII JNK 3 40 2.30258509299405 NA 5.03099615989946 4.77980630777224 0.251189852127226 0.56285864278066 0.757796487046845 0.335159060509343 0.446275197776632 0.331474025573964 0.578596783616679 NA NA NA 0.528495487667744 99.4001803783016 a6741 gain_cnaBRCA9_(KRAS) 1268 XAV 939 TNKS1 (tankyrase-1) 4 43 1.6094379124341 NA 3.91376160949824 3.63797115797874 0.275790451519502 0.582173798112036 0.963905606974024 0.292375375304621 0.473725290306568 0.286117696094005 0.578720376984732 NA NA NA 0.438596969188294 99.4064078827018 a6742 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1373 Dabrafenib BRAF 6 40 2.30258509299405 NA 4.56423711253374 4.16214193438519 0.402095178148546 0.743790248926418 1.72388857922945 0.244845456579315 0.540602916923054 0.233248936731327 0.578815685907997 NA NA NA 0.339992727596403 99.4064078827018 a6743 gain_cnaBRCA62 158 PF-562271 FAK 9 36 0.940007258491471 NA 2.54911631773727 2.27928367750784 0.269832640229423 1.40129829480025 1.26901608690138 0.208421218604805 0.192559029887271 0.212631378762334 0.578890584984073 NA NA NA 0.608713368789128 99.4064078827018 a6744 gain_cnaBRCA14_(RAD21) 165 DMOG Prolyl-4-Hydroxylase 20 26 8.29404964010203 NA 7.71484273061781 7.45854815269826 0.256294577919548 1.83548257822368 1.2740704133556 0.166232474149373 0.139633348177884 0.201162019958167 0.579059665674142 NA NA NA 0.597413932110756 99.4206979365494 a6745 TP53_mut 1239 YK 4-279 RNA helicase A 33 9 2.30258509299405 NA 2.07215914149845 1.79866325520273 0.273495886295722 1.25962233041977 1.4538732291069 0.210252837648864 0.217125307872702 0.188115360280572 0.579205376540894 NA NA NA 0.616880667943806 99.4216848576665 a6746 gain_cnaBRCA63 165 DMOG Prolyl-4-Hydroxylase 6 40 8.29404964010203 NA 7.89787589626046 7.5207962801237 0.37707961613676 1.95542433774342 1.480424273879 0.244572751944434 0.19283774312225 0.254710506163709 0.579237141419655 NA NA NA 0.666569619378885 99.4216848576665 a6747 TP53_mut 345 KIN001-270 CDK9 38 11 2.99573227355399 NA 5.13732185868007 5.00486652643758 0.132455332242493 0.680580179529859 0.737737715199365 0.19109567720926 0.19462120147841 0.179542579311807 0.57939990841553 NA NA NA 0.601436931358962 99.4348080073093 a6748 gain_cnaBRCA63 1036 PLX4720 BRAF 5 38 2.30258509299405 NA 4.31295254451569 4.63393977593215 -0.320987231416467 2.98496649887989 0.808459122262729 0.265731889701601 0.107534617737559 0.397035821079095 0.579485724716704 NA NA NA 0.822419667606526 99.4348080073093 a6749 ARID1A_mut 1494 SN-38 TOP1 5 43 -2.99573227355399 NA -3.70292075525263 -3.25737778372254 -0.445542971530088 1.53834185637774 1.70436930750795 0.263544519633831 0.28962546243082 0.261412224197784 0.579708184655868 NA NA NA 0.570038621794819 99.4348080073093 a6750 MLL3_mut 1175 AG-014699 PARP1, PARP2 3 40 1.6094379124341 NA 3.54111163443257 3.88560507461201 -0.344493440179435 1.39877120504497 1.00883137905575 0.334044775964106 0.246282908124606 0.341477720986311 0.579855440604158 NA NA NA 0.713578749893493 99.4348080073093 a6751 NF1_mut 222 BX-912 PDPK1 (PDK1) 5 44 2.32630161961136 NA 3.52523576169821 3.92452453193477 -0.399288770236555 0.983902141949544 1.55837244204204 0.263041440309463 0.405821629217503 0.256221657586129 0.579924950008679 NA NA NA 0.451453243458321 99.4348080073093 a6752 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 333 T0901317 LXR 7 41 2.32630161961136 NA 4.88486526049599 4.7099239284379 0.174941332058094 0.998126672205354 0.726850611440925 0.227880139875299 0.175269669601718 0.240684026819881 0.580078447647242 NA NA NA 0.670174257443942 99.4348080073093 a6753 gain_cnaBRCA8_(CHD4,WNK1) 202 GSK-1904529A IGF1R 3 45 0.0237165266173161 NA 1.92916629992478 2.2070416332345 -0.277875333309721 0.870336098137667 0.834779528698709 0.332244922350352 0.319273593160521 0.332872721187695 0.580097736070723 NA NA NA 0.639767458404717 99.4348080073093 a6754 BRCA2_mut 1017 Olaparib PARP1, PARP2 5 40 1.6094379124341 NA 3.86431958461303 4.10032041196839 -0.236000827355356 1.14415754185965 0.863611453232326 0.264150628315513 0.206266024320193 0.273271998040382 0.580497589496391 NA NA NA 0.676099799226757 99.4348080073093 a6755 loss_cnaBRCA18 231 FMK RSK 16 33 2.99573227355399 2.32630161961136 5.52120200773667 5.62221281961275 -0.101010811876079 0.404099516904287 0.667026922016509 0.169522399468624 0.249965188401855 0.151434385242968 0.580525914691095 NA NA NA 0.515018648609663 99.4348080073093 a6756 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1018 ABT-888 PARP1, PARP2 7 38 1.6094379124341 NA 4.27402809912645 4.42684820913426 -0.152820110007808 0.340137702448058 0.706289333516938 0.22898884420477 0.449288946529371 0.216370406228347 0.580594412550828 NA NA NA 0.386869505192525 99.4348080073093 a6757 gain_cnaBRCA30_(CRNKL1,FOXA2) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 5 41 0 NA 1.13930447588638 0.593935958779373 0.545368517107004 3.01393128851513 1.94911670735672 0.263629666743942 0.180949220436837 0.279802905104949 0.580665043161036 NA NA NA 0.711407140810314 99.4348080073093 a6758 gain_cnaBRCA14_(RAD21) 222 BX-912 PDPK1 (PDK1) 21 28 2.32630161961136 NA 4.02305812047285 3.77932277441753 0.243735346055323 1.51379634904194 1.52108828817187 0.160564567349848 0.161009336698149 0.16023747467562 0.580704545332778 NA NA NA 0.580661795960164 99.4348080073093 a6759 gain_cnaBRCA58_(CCND1) 1025 SB 216763 GSK3A, GSK3B 6 33 2.30258509299405 NA 5.05461496844978 4.85907885411614 0.195536114333645 0.445528337903234 0.831937130464924 0.247254024627624 0.438885919701284 0.235037128616162 0.580804663691866 NA NA NA 0.416061828307045 99.4348080073093 a6760 PTEN_mut 1248 FK866 NAMPT 7 37 0 NA -1.176461475588 -0.551238593702509 -0.625222881885486 2.74276856482087 2.72369364878079 0.229319518197725 0.227953203892112 0.229549634616711 0.580909616670921 NA NA NA 0.594236363135391 99.4348080073093 a6761 NF1_mut 1230 IOX2 EGLN1 5 42 -2.30258509299405 NA 0.403822422094589 0.23108655638246 0.172735865712129 0.675688460213848 0.654746847044625 0.263062079528958 0.255644244179425 0.263820843875489 0.580926720678314 NA NA NA 0.611279462598707 99.4348080073093 a6762 gain_cnaBRCA30_(CRNKL1,FOXA2) 235 QL-XII-47 BTK, BMX 5 44 2.32630161961136 NA 1.35239101304316 1.74849374047715 -0.396102727433992 1.04222501136686 1.54675157295222 0.26225218965062 0.380054904760451 0.256086843136656 0.581058648705361 NA NA NA 0.475068016482049 99.4348080073093 a6763 loss_cnaBRCA28_(GPS2) 1010 Gefitinib EGFR 3 42 -0.693147180559945 NA 1.72436907995516 1.37672129573038 0.347647784224782 0.721490735864077 1.05967949372701 0.332239738012145 0.481846497735595 0.328068804089119 0.58113099927539 NA NA NA 0.500383911974886 99.4348080073093 a6764 loss_cnaBRCA57 205 BMS-708163 g-secretase 5 43 2.32630161961136 0.940007258491471 4.73616580097851 4.9151764614151 -0.179010660436596 0.825708782761476 0.66657314417726 0.262522500615163 0.21679636231786 0.26855366436574 0.581174108998299 NA NA NA 0.661402322749783 99.4348080073093 a6765 gain_cnaBRCA15 1192 GSK269962A ROCK1, ROCK2 22 24 1.6094379124341 NA 2.79373495550448 2.55263493050124 0.241100025003237 1.68318450959031 1.24410928338023 0.164000432976791 0.143240401530265 0.193793285062684 0.581280496681622 NA NA NA 0.586569157819391 99.4348080073093 a6766 gain_cnaBRCA9_(KRAS) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 4 44 2.32630161961136 NA 4.77268225348966 4.97538205347605 -0.202699799986386 0.903906225064611 0.682188776684462 0.29006996022415 0.224248704528942 0.297131537360577 0.581283994583773 NA NA NA 0.688800758421939 99.4348080073093 a6767 PTEN_mut 1016 Temsirolimus MTOR 6 38 -1.6094379124341 NA -2.06827601177368 -1.70083542448501 -0.36744058728867 1.32257810294257 1.52842973195451 0.24408163977269 0.277821465871211 0.240403977760102 0.581419905750995 NA NA NA 0.555120462865828 99.4348080073093 a6768 gain_cnaBRCA8_(CHD4,WNK1) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 3 44 2.77258872223978 NA 5.33015737892037 4.98913403546189 0.341023343458488 0.477712577189614 1.04780844579473 0.331348472471601 0.713867207484322 0.325463442127374 0.581443701244277 NA NA NA 0.351463785952043 99.4348080073093 a6769 gain_cnaBRCA10_(MDM2,NUP107) 166 FTI-277 Farnesyl transferase (FNTA) 4 43 0.0237165266173161 NA 2.46173101500934 2.22416995344215 0.23756106156719 0.625385517356748 0.830654315441151 0.290213755485616 0.37986338822054 0.28599268931869 0.581521490770507 NA NA NA 0.519657444195259 99.4348080073093 a6770 loss_cnaBRCA7_(FAS,PTEN) 172 Embelin XIAP 4 44 3.46573590279973 NA 3.25130503397173 2.96958555668977 0.281719477281958 0.476820537605186 0.997306668258192 0.28986588607988 0.590829159114841 0.282480290414567 0.581549046127451 NA NA NA 0.357428155922383 99.4348080073093 a6771 gain_cnaBRCA58_(CCND1) 208 SB-715992 KIF11 10 39 -2.05572501506252 NA -0.971437164871239 -1.30873572425827 0.337298559387029 1.92065541585063 1.66272772641724 0.196661395301655 0.175616384179795 0.202858564290512 0.581647610271989 NA NA NA 0.619749477403144 99.4348080073093 a6772 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1259 BMN-673 PARP1 18 28 2.30258509299405 NA 3.14592244833902 3.40814806402647 -0.262225615687449 1.51164343256632 1.59584171297139 0.167679728972559 0.173470548700938 0.164318060842761 0.581684598762642 NA NA NA 0.577596453524941 99.4348080073093 a6773 TP53_mut 330 XMD13-2 RIPK 37 11 2.32630161961136 NA 3.77436729578699 3.5415845257752 0.23278277001179 1.1313833978168 1.50256420420544 0.190539108603071 0.205750562064977 0.154923676046766 0.581698237032332 NA NA NA 0.642128374152279 99.4348080073093 a6774 loss_cnaBRCA18 1199 Tamoxifen ER 15 32 1.6094379124341 NA 3.98233286738703 3.81612523240567 0.166207634981355 0.857290645431517 0.99909210567029 0.173634000833374 0.193875479532026 0.166358671075523 0.581718101253574 NA NA NA 0.561403473261046 99.4348080073093 a6775 gain_cnaBRCA30_(CRNKL1,FOXA2) 1058 GDC0941 PI3K (class 1) 4 39 1.38629436111989 0.693147180559945 1.71420770519904 1.30823794024764 0.405969764951406 0.72269821262188 1.43274130480587 0.291411994099312 0.561741758677645 0.283351756237958 0.581873332016323 NA NA NA 0.380522976136266 99.4376656736132 a6776 gain_cnaBRCA62 1047 Nutlin-3a MDM2 7 36 2.07944154167984 1.38629436111989 4.01314854053955 4.24462712896505 -0.231478588425497 1.42000594555885 0.921467883907769 0.229205879680853 0.163012407905375 0.251206355064531 0.581997774173141 NA NA NA 0.690786067483345 99.4376656736132 a6777 BRCA2_mut 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 5 41 0 NA 0.168999236419419 0.712265866031441 -0.543266629612022 1.72918752370847 2.09968571575067 0.262606509297319 0.314174502281231 0.258737117434642 0.582129353536196 NA NA NA 0.543581884519744 99.4376656736132 a6778 ARID1A_mut 238 CAL-101 PI3Kdelta 5 44 2.99573227355399 2.32630161961136 4.49602882946276 4.74429778647398 -0.248268957011221 1.17251286944613 0.925906619361134 0.261503246161165 0.211740922833963 0.268136064501325 0.582135438168609 NA NA NA 0.668143648425146 99.4376656736132 a6779 BRCA1_mut 1149 TW 37 BCL2, BCL2L1 4 39 1.6094379124341 NA 0.188486922751429 -0.17631974641657 0.364806669167999 0.825610986046826 1.28063398964459 0.291156938823953 0.441862663328596 0.284864115834722 0.582202591814934 NA NA NA 0.46718088847588 99.4376656736132 a6780 ASH1L_mut 225 Genentech Cpd 10 AURKA, AURKB 3 46 2.32630161961136 NA 3.52018965597995 2.98531608542501 0.534873570554943 1.7227850084135 1.61574746961351 0.330077937221636 0.310470295447662 0.331037851281851 0.582250084866653 NA NA NA 0.648260511393481 99.4376656736132 a6781 loss_cnaBRCA28_(GPS2) 286 KIN001-236 TIE2 4 45 2.32630161961136 NA 4.74421933227036 4.52196040505468 0.222258927215674 0.543494885779009 0.783293007353247 0.288565285789636 0.408943916550573 0.283749408113177 0.582834875149245 NA NA NA 0.492298520223759 99.4766901953356 a6782 loss_cnaBRCA18 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 7 19 2.30258509299405 NA 2.46821556323634 2.77382098820274 -0.305605424966394 0.750090610092355 1.36677342581462 0.246127164596645 0.407424677571642 0.223596259039239 0.58290628701189 NA NA NA 0.478174312314248 99.4766901953356 a6783 gain_cnaBRCA12_(TERT) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 9 39 2.07944154167984 NA 3.40802033649628 3.16959955412088 0.238420782375398 0.729498822351969 1.23845628464282 0.204475580855278 0.326828193644931 0.192514491897597 0.582984965829614 NA NA NA 0.456090720038149 99.4766901953356 a6784 loss_cnaBRCA7_(FAS,PTEN) 1049 PD-173074 FGFR1, FGFR3 4 39 0.693147180559945 NA 2.63552746369928 2.968762607971 -0.333235144271724 1.23151037698542 1.14136399334599 0.290223933667176 0.270590610115231 0.291962201553967 0.583407809014527 NA NA NA 0.634535391952081 99.4766901953356 a6785 loss_cnaBRCA36_(FAT1,IRF2) 170 Shikonin unknown 9 38 2.77258872223978 NA -0.193711907950861 0.0503416712042154 -0.244053579155077 1.10762245573906 1.20926493126446 0.204772334592414 0.220340042665741 0.201819777325291 0.583423623292969 NA NA NA 0.569437989679057 99.4766901953356 a6786 gain_cnaBRCA10_(MDM2,NUP107) 202 GSK-1904529A IGF1R 4 44 0.0237165266173161 NA 2.41077319499803 2.16957453671216 0.241198658285868 0.427769009060714 0.857681626557987 0.288374764693266 0.56385257738864 0.281221668760513 0.583487484079117 NA NA NA 0.37471484672563 99.4766901953356 a6787 loss_cnaBRCA34 1033 Vismodegib SMO 5 40 2.30258509299405 NA 4.57687383242799 4.78263716183862 -0.205763329410623 0.268014236942262 0.820804426168106 0.261799327571988 0.767732832994805 0.250684965688138 0.58385945625517 NA NA NA 0.260647643715904 99.4766901953356 a6788 gain_cnaBRCA15 283 GSK2126458 PI3K, MTOR 22 26 -2.05572501506252 0.0237165266173161 -3.19726009063822 -2.9352868230115 -0.261973267626714 1.58511140881886 1.68658473808431 0.15963870567506 0.165271201865818 0.155327664072351 0.584244913135196 NA NA NA 0.582296265434458 99.4766901953356 a6789 gain_cnaBRCA16 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 16 33 1.63315443905142 NA 3.69016404609183 3.52162312951561 0.168540916576221 1.21971948709062 0.88522109401343 0.167843389788955 0.138180063826183 0.190394148666395 0.584268120124692 NA NA NA 0.626485355539087 99.4766901953356 a6790 loss_cnaBRCA33 166 FTI-277 Farnesyl transferase (FNTA) 6 41 0.0237165266173161 NA 2.07249257422731 2.26954333201673 -0.197050757789418 0.739555260536991 0.827969571570507 0.240711648637725 0.266444941039754 0.237992753061745 0.584562534013725 NA NA NA 0.567517488104077 99.4766901953356 a6791 gain_cnaBRCA9_(KRAS) 1009 ATRA Retinoic acid and retinoid X receptor agonist 4 41 2.30258509299405 NA 4.41154544428013 4.07615871815222 0.335386726127908 1.77626388440587 1.10296762162309 0.288464071764495 0.188815822396845 0.304076674194991 0.584695907823306 NA NA NA 0.733839134326028 99.4766901953356 a6792 gain_cnaBRCA62 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 7 35 1.38629436111989 0.693147180559945 3.63280694048666 3.39355435977952 0.239252580707145 1.28386425986908 1.00227939359864 0.228001771161856 0.186353486256827 0.238708470148348 0.584918030695542 NA NA NA 0.654741319846018 99.4766901953356 a6793 PIK3CA_mut 254 AC220 FLT3 16 32 0.0237165266173161 NA 2.32332672936818 2.17397948111815 0.14934724825003 0.569089569548847 1.00542761328641 0.168364154884879 0.262431884612516 0.148541025009113 0.585065221896836 NA NA NA 0.515157336917866 99.4766901953356 a6794 MACF1_mut 1495 AZD-2281 PARP1, PARP2 3 42 2.30258509299405 NA 3.65039763841493 4.02356941542249 -0.373171777007564 0.465492209020206 1.15786436571581 0.328766903400461 0.801671370167584 0.322293170130392 0.585075203325162 NA NA NA 0.310174825745184 99.4766901953356 a6795 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1143 HG-5-88-01 EGFR, ADCK4 13 13 2.30258509299405 NA 4.42709567616239 4.64105841853449 -0.213962742372094 0.974720547955461 0.997776247294596 0.216931280459572 0.219511882478413 0.214439603019454 0.585332050322126 NA NA NA 0.585334824899941 99.4766901953356 a6796 loss_cnaBRCA28_(GPS2) 310 YM201636 FYV1 4 45 1.63315443905142 NA 2.68340637766481 2.39077958212252 0.292626795542295 0.779044250960598 1.03574059141286 0.28652797703565 0.37562281626682 0.282529040542015 0.585489991238106 NA NA NA 0.52331923516245 99.4766901953356 a6797 gain_cnaBRCA27_(CLTC,PPM1D) 341 EX-527 SIRT1 9 40 2.99573227355399 NA 5.53305107249939 5.66621122620807 -0.133160153708687 0.703637417328219 0.647401626765873 0.202582401391849 0.189245413091176 0.205683996152273 0.58553330372692 NA NA NA 0.612909733904032 99.4766901953356 a6798 gain_cnaBRCA48 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 39 1.6094379124341 NA 2.14573563854696 2.61058301400587 -0.464847375458911 1.39931017185709 1.62665747659792 0.288526065464525 0.332197524757496 0.285768443662225 0.58560413291311 NA NA NA 0.568210189188329 99.4766901953356 a6799 gain_cnaBRCA15 1061 SB590885 BRAF 20 22 1.6094379124341 NA 4.10911288090297 3.92354698324375 0.185565897659227 0.885966502073577 1.25160659281349 0.169732741937295 0.209450241318284 0.148262160590008 0.585803722772538 NA NA NA 0.579891760159718 99.4766901953356 a6800 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1058 GDC0941 PI3K (class 1) 6 37 1.38629436111989 0.693147180559945 1.63578527755308 1.29901077905772 0.336774498495365 1.52057455095174 1.37460020363477 0.24172366497742 0.221478452526103 0.244998143900207 0.585820590995787 NA NA NA 0.627311500092912 99.4766901953356 a6801 PIK3CA_mut 52 GNF-2 ABL [T315I] 4 8 0.246860077931526 NA 2.61932031272859 2.42059653851431 0.198723774214274 0.607667333293989 0.562549522292259 0.344733777353009 0.32702724554412 0.353255609220893 0.585869565087646 NA NA NA 0.605049954076412 99.4766901953356 a6802 loss_cnaBRCA18 1502 Bicalutamide ANDR (androgen receptor) 14 31 2.30258509299405 NA 4.62967100690683 4.52607248019377 0.103598526713059 0.418888783149573 0.645353257637476 0.176732581118869 0.247317500206413 0.16052995082463 0.585945895413382 NA NA NA 0.524237080315699 99.4766901953356 a6803 loss_cnaBRCA28_(GPS2) 254 AC220 FLT3 4 44 0.0237165266173161 NA 2.45665135696996 2.20259012813163 0.25406122883833 0.418882282196121 0.910790931972522 0.286406814474811 0.606521783414508 0.278945716211846 0.586050543963541 NA NA NA 0.349167301340418 99.4766901953356 a6804 loss_cnaBRCA57 193 GW-2580 CSF1R (cFMS) 5 43 2.99573227355399 NA 5.63725284215258 5.44317212629246 0.194080715860127 0.491144783758981 0.769043819064055 0.259125607815075 0.39515988416843 0.252366264507955 0.586059242606212 NA NA NA 0.462918080904311 99.4766901953356 a6805 gain_cnaBRCA13_(FGFR1,WHSC1L1) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 11 37 2.32630161961136 NA 5.05993442090759 4.92833137126814 0.131603049639448 0.743630235530217 0.685899351183325 0.188312289330833 0.176973774534079 0.191869330992083 0.586105407973845 NA NA NA 0.607471969656374 99.4766901953356 a6806 gain_cnaBRCA27_(CLTC,PPM1D) 3 Rapamycin MTOR 3 11 -2.30258509299405 NA -3.51325171957453 -2.53195770222695 -0.981294017347579 4.56030164369085 2.13353102340514 0.364208571412086 0.215181822172924 0.459938949367337 0.5863309447444 NA NA NA 0.748601671831263 99.4766901953356 a6807 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1032 Afatinib ERBB2, EGFR 5 40 -0.693147180559945 NA 0.715870767529785 0.237296814753309 0.478573952776476 1.19197446705837 1.89424414174245 0.260058202030471 0.401496815579892 0.252646394532994 0.586354934265826 NA NA NA 0.459989243151635 99.4766901953356 a6808 loss_cnaBRCA29_(MAP2K4) 136 Mitomycin C DNA crosslinker 7 41 2.77258872223978 NA -0.418415304298857 -0.085798697178457 -0.3326166071204 1.33129170047276 1.50669491799364 0.22398550737218 0.249845024198891 0.220759095386957 0.586547980594068 NA NA NA 0.564327138701422 99.4766901953356 a6809 gain_cnaBRCA64_(SDHC) 1013 Nilotinib ABL 7 33 0.693147180559945 NA 3.02164992755366 3.24135593343475 -0.219706005881094 1.68392413818333 0.75420016711791 0.228225989431761 0.130472626942756 0.29130994059664 0.586587478985725 NA NA NA 0.74592675823851 99.4766901953356 a6810 loss_cnaBRCA17 308 XL-880 MET 11 38 1.63315443905142 NA 1.61351641470019 1.91552764379958 -0.302011229099388 1.37733507377175 1.66869101404816 0.18745432034942 0.219272154503659 0.180986909234158 0.586624732725033 NA NA NA 0.549449369505698 99.4766901953356 a6811 loss_cnaBRCA24 303 PIK-93 PI4K, PI3K 3 46 2.99573227355399 NA 2.35422845598208 2.82004668295143 -0.465818226969348 0.808549642642912 1.44934083357503 0.326216250426315 0.576115803411556 0.321400057307661 0.586657767097441 NA NA NA 0.432781248119479 99.4766901953356 a6812 loss_cnaBRCA38 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 4 43 2.77258872223978 NA 4.74139738962621 5.03597163112975 -0.294574241503541 0.843788273627981 1.04128305841114 0.286189923946718 0.349109190907547 0.282895452033015 0.58675311685992 NA NA NA 0.549935726352849 99.4766901953356 a6813 NF1_mut 1038 NU-7441 PRKDC (DNAPK) 4 39 0.693147180559945 NA 2.6453748685349 2.91824862050757 -0.272873751972678 0.995812078211519 0.945612288517564 0.28742448595885 0.274021331878962 0.288568322647818 0.587031237251129 NA NA NA 0.630829548649779 99.4766901953356 a6814 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 223 ZSTK474 PI3K 9 40 1.63315443905142 2.32630161961136 1.15179314329425 0.858460545391144 0.293332597903108 1.36069730462057 1.47218070533601 0.201768365822917 0.215575203174892 0.199250402372417 0.587036240221408 NA NA NA 0.575175582941099 99.4766901953356 a6815 loss_cnaBRCA28_(GPS2) 330 XMD13-2 RIPK 4 44 2.32630161961136 NA 3.40117432895814 3.75009823663212 -0.348923907673985 0.667843320196698 1.25135302138326 0.285576671836198 0.522463723334416 0.278837307867193 0.58713333800443 NA NA NA 0.403256508010049 99.4766901953356 a6816 gain_cnaBRCA47_(EGFR) 1241 CHIR-99021 GSK3B 6 40 2.30258509299405 NA 4.43595383428351 4.20081708121746 0.235136753066056 0.728261939212541 1.01002150132851 0.239426580377481 0.322873873266405 0.232803710373268 0.587218174051313 NA NA NA 0.505210269297853 99.4766901953356 a6817 loss_cnaBRCA36_(FAT1,IRF2) 1054 PD-0332991 CDK4, CDK6 9 33 1.38629436111989 0.693147180559945 2.6447633920707 2.94785237820073 -0.303088986130032 1.58308118180676 1.44394707492207 0.205787401083565 0.191455112734091 0.209903113066931 0.587259036294281 NA NA NA 0.613594209649234 99.4766901953356 a6818 gain_cnaBRCA15 41 S-Trityl-L-cysteine KIF11 6 6 1.63315443905142 NA 0.95422690086998 1.49406479434433 -0.539837893474348 1.80029543358426 1.52333074537194 0.323726670594673 0.299860724747587 0.35437996319213 0.587336826384101 NA NA NA 0.587668360359753 99.4766901953356 a6819 PIK3CA_mut 207 AS601245 JNK 17 31 2.07944154167984 NA 2.4035069268256 2.19090375726415 0.212603169561458 1.75872149714433 0.947667564206454 0.164934499458736 0.12088506901557 0.224343617521071 0.587358317658172 NA NA NA 0.648129519518572 99.4766901953356 a6820 loss_cnaBRCA29_(MAP2K4) 1046 681640 WEE1, CHEK1 5 31 0.693147180559945 NA 2.38994874257751 2.67312490634667 -0.283176163769157 0.889401478694296 1.09475121899177 0.264000527997128 0.318389580580505 0.258667137205796 0.587410110143952 NA NA NA 0.546366210488556 99.4766901953356 a6821 loss_cnaBRCA17 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 4 22 2.30258509299405 NA 2.37750723523547 2.74863994443475 -0.371132709199279 0.681149013214076 1.30239213717905 0.298854584324289 0.544862727537473 0.284962338611121 0.58752861504675 NA NA NA 0.423422205509501 99.4766901953356 a6822 gain_cnaBRCA10_(MDM2,NUP107) 231 FMK RSK 5 44 2.99573227355399 2.32630161961136 5.72715613862653 5.57355623813352 0.15359990049301 0.477259475937723 0.605785175877763 0.257749538189196 0.321837298654397 0.253555066398659 0.587546754756539 NA NA NA 0.534551056775926 99.4766901953356 a6823 NF1_mut 165 DMOG Prolyl-4-Hydroxylase 4 42 8.29404964010203 NA 7.16743292441459 7.60831844963935 -0.440885525224757 1.37449727965682 1.55357357283749 0.285913420332126 0.320761293419829 0.283787992363639 0.587551587423459 NA NA NA 0.579255246963036 99.4766901953356 a6824 loss_cnaBRCA34 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 5 42 2.99573227355399 NA 3.51665098764687 3.88706847559637 -0.370417487949495 1.48382198008706 1.42895479522339 0.258325631906908 0.249637418046443 0.259222677433674 0.58773226062077 NA NA NA 0.619294667416264 99.4766901953356 a6825 loss_cnaBRCA22_(SYNCRIP,ZNF292) 37 Crizotinib MET, ALK 4 10 0.693147180559945 NA 2.46525865843926 2.72710601179163 -0.261847353352373 0.779535251130591 0.799737152112492 0.329477639978745 0.335901876114782 0.327416767697621 0.587819606868333 NA NA NA 0.594434938787805 99.4766901953356 a6826 MLL3_mut 287 KIN001-244 PDPK1 (PDK1) 3 46 2.99573227355399 NA 3.1891135538897 3.49695337802898 -0.307839824139275 0.975865785129199 0.945460774366588 0.325145877333272 0.315453035479176 0.325597668867344 0.587882297349601 NA NA NA 0.643550704310724 99.4766901953356 a6827 loss_cnaBRCA38 341 EX-527 SIRT1 4 45 2.99573227355399 NA 5.46990727981014 5.65702843514615 -0.187121155336016 0.280690950526542 0.675414983473577 0.284664089134539 0.666644774208073 0.27704620109799 0.587924164206332 NA NA NA 0.315774550838802 99.4766901953356 a6828 CDH1_mut 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 4 39 0.693147180559945 NA 2.65867346946728 2.93403358829027 -0.275360118822986 0.875229066930631 0.966848025804402 0.286701873812269 0.314614915371419 0.284801862830398 0.587968292849675 NA NA NA 0.586598249294013 99.4766901953356 a6829 loss_cnaBRCA23 1264 SGC0946 Q8TEK3 (DOT1L) 3 43 -0.693147180559945 NA 1.76496961965532 1.96367255008849 -0.198702930433169 0.761578745125666 0.601520702249466 0.325898356395402 0.260909238479839 0.330334317156656 0.587990465154241 NA NA NA 0.698307514841842 99.4766901953356 a6830 gain_cnaBRCA15 309 Y-39983 ROCK 22 27 2.99573227355399 NA 4.84106541115508 5.01150468110897 -0.170439269953882 1.27414859821263 0.910210245257419 0.156657781987211 0.133767183979148 0.18725263843375 0.588030181906808 NA NA NA 0.60113870908667 99.4766901953356 a6831 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 17 26 1.6094379124341 NA 3.10165398654567 2.84407176607555 0.257582220470114 1.41170199106377 1.57389904395517 0.170282789054635 0.182462178349707 0.163658667599681 0.588063293381101 NA NA NA 0.57969065835511 99.4766901953356 a6832 ARID1A_mut 1022 AZD7762 CHEK1, CHEK2 5 40 0.693147180559945 NA 1.27986003484555 0.857862016965026 0.421998017880522 2.04184876243224 1.58199604566153 0.258854124366536 0.206674473469739 0.266750362011214 0.588083674593529 NA NA NA 0.675904328985317 99.4766901953356 a6833 gain_cnaBRCA14_(RAD21) 201 Epothilone B Microtubules 21 27 -3.44201937618241 NA -4.07401381304745 -4.36155890055966 0.287545087512208 1.8497839196994 1.7830820670495 0.158655672776627 0.155447933377503 0.161262957452101 0.588189375108364 NA NA NA 0.590155854859506 99.4766901953356 a6834 POLR2B_mut 1011 ABT-263 BCL2, BCL2L1, BCL2L2 3 40 0.693147180559945 NA 1.17190190043704 1.7202004057399 -0.548298505302863 3.62765706857754 1.51318357114199 0.326508352816084 0.151143973903205 0.36234764622052 0.588403086860541 NA NA NA 0.818564188910642 99.4766901953356 a6835 BRCA1_mut 1046 681640 WEE1, CHEK1 3 33 0.693147180559945 NA 2.30998213961801 2.66323240578122 -0.353250266163209 1.44782330399753 1.04475264007749 0.329320649412288 0.243987139306201 0.338118567603722 0.588551721545243 NA NA NA 0.716556400668338 99.4766901953356 a6836 CDH1_mut 1016 Temsirolimus MTOR 4 40 -1.6094379124341 NA -1.35966965917884 -1.79006808910893 0.430398429930091 0.836041508169663 1.54513939228564 0.285863926595822 0.514805097264079 0.278549904350977 0.588553503081965 NA NA NA 0.412213150074864 99.4766901953356 a6837 gain_cnaBRCA16 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 16 33 3.68887945411394 NA 3.32535956122909 3.52447634077514 -0.199116779546049 1.06726276545828 1.25781846905382 0.165889989995981 0.186567718832156 0.158303272248684 0.588636419619439 NA NA NA 0.567745489344867 99.4766901953356 a6838 gain_cnaBRCA15 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 21 24 2.30258509299405 NA 3.29047599315701 3.07745909014743 0.213016903009585 0.917122456380342 1.57127620788294 0.162812675302628 0.232266587223597 0.135569355623728 0.588654218283103 NA NA NA 0.576450456567544 99.4766901953356 a6839 gain_cnaBRCA15 295 NVP-BHG712 EPHB4 22 27 2.32630161961136 NA 3.99302229894365 3.80008199208558 0.192940306858071 1.28546845305161 1.19120135603316 0.156326862690592 0.150093381443974 0.161971194778173 0.588816352612146 NA NA NA 0.591957490519493 99.4766901953356 a6840 gain_cnaBRCA19 1058 GDC0941 PI3K (class 1) 3 40 1.38629436111989 0.693147180559945 1.76869765892379 1.31430043784206 0.454397221081728 0.781788201923791 1.41756932891274 0.326129565542263 0.581228035884356 0.320546735749598 0.588834288068665 NA NA NA 0.431770675854283 99.4766901953356 a6841 BRCA1_mut 1008 Methotrexate Dihydrofolate reductase (DHFR) 4 41 -1.6094379124341 NA 0.967001314045435 0.654908490097611 0.312092823947824 0.621004279202491 1.12217125023916 0.285100350884353 0.502561470830155 0.278115148540216 0.589067920974467 NA NA NA 0.420152589089312 99.4766901953356 a6842 PTEN_mut 221 TAK-715 p38a 9 40 2.99573227355399 2.32630161961136 4.3165755014591 4.51940758669383 -0.202832085234728 0.911381478729856 1.03016853685331 0.200637980195628 0.222554539420094 0.1968921375276 0.589126300185082 NA NA NA 0.566302589025617 99.4766901953356 a6843 BRCA1_mut 1194 SB-505124 TGFR1 (ALK5) 4 43 2.30258509299405 NA 4.62890211782538 4.36668252844687 0.262219589378509 0.506465943197281 0.944879108061961 0.284353978849882 0.517743775076239 0.277516549092028 0.589147606678636 NA NA NA 0.407738548510665 99.4766901953356 a6844 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1050 ZM-447439 AURKB 5 34 1.38629436111989 0.693147180559945 2.5867254822605 2.93221799322063 -0.345492510960134 1.65589545873756 1.27810917719163 0.26091497502398 0.208643914769556 0.270315335438932 0.589199227411899 NA NA NA 0.674366373180444 99.4766901953356 a6845 gain_cnaBRCA64_(SDHC) 221 TAK-715 p38a 8 41 2.99573227355399 2.32630161961136 4.3044345232959 4.51682943401263 -0.212394910716732 1.26994031502521 0.95844431187026 0.210096731804862 0.167247947170269 0.221603809513226 0.589304248065868 NA NA NA 0.6646630069031 99.4766901953356 a6846 gain_cnaBRCA14_(RAD21) 221 TAK-715 p38a 21 28 2.99573227355399 2.32630161961136 4.57279372603727 4.41417195478938 0.158621771247891 1.10885898130728 0.931795063580723 0.156905367251849 0.143049543649713 0.17023246575093 0.589329677953818 NA NA NA 0.599110347949121 99.4766901953356 a6847 gain_cnaBRCA27_(CLTC,PPM1D) 175 PAC-1 CASP3 agonist 9 39 0.940007258491471 NA 2.20082096846925 2.44766506948477 -0.246844101015516 0.984228581114944 1.2733713206092 0.201015408180529 0.250799566027526 0.193850840693838 0.589356385597419 NA NA NA 0.532499135161515 99.4766901953356 a6848 BRCA1_mut 1377 Afatinib (rescreen) ERBB2, EGFR 4 43 2.30258509299405 NA 3.353832909288 2.78634312727849 0.567489782009511 1.83579634834413 2.00799424377487 0.284174507299205 0.30912458373794 0.28261524342952 0.589381928230385 NA NA NA 0.591442739508628 99.4766901953356 a6849 loss_cnaBRCA20 1239 YK 4-279 RNA helicase A 3 39 2.30258509299405 NA 2.40731609429227 1.98326340213837 0.424052692153893 0.601465307621657 1.32771292266163 0.325927521310421 0.705032670680047 0.319385828755666 0.589469284753136 NA NA NA 0.36004885227253 99.4766901953356 a6850 MLL3_mut 1239 YK 4-279 RNA helicase A 3 39 2.30258509299405 NA 1.61989620939899 2.04383416251478 -0.423937953115794 1.1005597969614 1.31077065853674 0.325838680558436 0.385202107405949 0.323426489870509 0.589570373184253 NA NA NA 0.580330733980389 99.4766901953356 a6851 gain_cnaBRCA9_(KRAS) 222 BX-912 PDPK1 (PDK1) 4 45 2.32630161961136 NA 3.48867783749381 3.91890104141434 -0.430223203920538 0.898781043631424 1.55147493986631 0.283373325893114 0.478674096398685 0.277299486356905 0.589612682027635 NA NA NA 0.43522470875269 99.4766901953356 a6852 loss_cnaBRCA34 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 41 1.38629436111989 NA 3.19986458419149 2.81699273906383 0.382871845127662 1.1133239120107 1.52047915577903 0.257293276112189 0.343899777052469 0.251809992706867 0.589762030517287 NA NA NA 0.513608713464836 99.4766901953356 a6853 gain_cnaBRCA9_(KRAS) 298 OSI-930 KIT, VEGFR, PDGFR 4 44 2.32630161961136 NA 3.68522982073289 3.93410706696126 -0.248877246228364 1.03936250484587 0.86528640191632 0.283558678343043 0.239451822697097 0.287624127314591 0.589769484095326 NA NA NA 0.670532419720367 99.4766901953356 a6854 gain_cnaBRCA15 1373 Dabrafenib BRAF 21 25 2.30258509299405 NA 4.35807778244915 4.09405866476711 0.264019117682039 1.06611518896948 1.99981208674799 0.160735111922807 0.247645958348313 0.132021963179239 0.589860163778401 NA NA NA 0.571646493091934 99.4766901953356 a6855 loss_cnaBRCA57 211 TL-2-105 CRAF 5 44 2.32630161961136 1.63315443905142 4.15894427578013 3.87898662978554 0.279957645994596 1.47890888738185 1.0498822665189 0.256143636827995 0.189300130916254 0.266656228914938 0.589869125708425 NA NA NA 0.699570878247909 99.4766901953356 a6856 gain_cnaBRCA31 1010 Gefitinib EGFR 14 31 -0.693147180559945 NA 1.27384455941114 1.45682509125114 -0.182980531840002 1.17475490518541 0.98582785011019 0.174841916798129 0.155760602515742 0.185611039310311 0.589946965403071 NA NA NA 0.616839959517991 99.4766901953356 a6857 gain_cnaBRCA64_(SDHC) 1005 Cisplatin DNA crosslinker 9 36 1.79175946922805 2.30258509299405 3.86222511771205 3.62204816005468 0.240176957657372 1.46460569765639 1.11542082883008 0.202138359321579 0.163987452760626 0.21532407451032 0.590347192169524 NA NA NA 0.655118024431472 99.4766901953356 a6858 BRCA1_mut 346 THZ-2-102-1 CDK7 4 44 0.916290731874155 2.99573227355399 -0.6719139684816 -1.39545251778763 0.723538549306034 2.79195649862248 2.53842659603446 0.283104687446429 0.259151082641516 0.285034261158604 0.590363317209353 NA NA NA 0.64720903654243 99.4766901953356 a6859 gain_cnaBRCA47_(EGFR) 344 THZ-2-49 CDK9 7 42 2.99573227355399 NA 1.50463988541044 1.83204751370273 -0.327407628292293 2.02101976356887 1.38338836493345 0.221197067337661 0.162001200678083 0.236670798014152 0.590502112232179 NA NA NA 0.692159879790661 99.4766901953356 a6860 gain_cnaBRCA15 303 PIK-93 PI4K, PI3K 22 27 2.99573227355399 NA 2.669101549366 2.89128143324666 -0.222179883880663 1.45597020468625 1.40507135344547 0.155584055742893 0.152599196855503 0.158127118125241 0.590582873526282 NA NA NA 0.592105918277648 99.4766901953356 a6861 loss_cnaBRCA33 71 Pyrimethamine Dihydrofolate reductase (DHFR) 5 9 2.99573227355399 NA 4.36724780769305 4.68195008418372 -0.314702276490669 0.987450652911318 1.03731415261747 0.308240443269622 0.318701775691602 0.303381840203932 0.590664659252191 NA NA NA 0.588788523696707 99.4766901953356 a6862 loss_cnaBRCA57 1049 PD-173074 FGFR1, FGFR3 5 38 0.693147180559945 NA 3.19942891254356 2.90333439481443 0.296094517729125 1.24257762947238 1.13771201684033 0.257840201398992 0.238290558840057 0.260254364326258 0.590757425081747 NA NA NA 0.634899259146697 99.4766901953356 a6863 gain_cnaBRCA61_(NOTCH2) 136 Mitomycin C DNA crosslinker 3 45 2.77258872223978 NA 0.315196173248168 -0.16427204964785 0.479468222896018 1.653724832885 1.47697887223186 0.322852277845892 0.289932287017522 0.324627678777485 0.590817408338846 NA NA NA 0.668762827868483 99.4766901953356 a6864 loss_cnaBRCA17 1049 PD-173074 FGFR1, FGFR3 6 37 0.693147180559945 NA 3.17341159130134 2.89955086534752 0.273860725953826 0.705664310471291 1.19697240178285 0.238478536295206 0.388089240011193 0.228794519861878 0.590844011763179 NA NA NA 0.449917391088568 99.4766901953356 a6865 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 268 YM155 BIRC5 (Survivin) 7 42 1.63315443905142 NA -3.89959414561124 -3.5449086447044 -0.354685500906838 1.44778234568535 1.62690225776801 0.220967304837071 0.244985375021227 0.218012790389412 0.590886837400638 NA NA NA 0.570691357918844 99.4766901953356 a6866 loss_cnaBRCA20 1248 FK866 NAMPT 3 41 0 NA -1.47381100969897 -0.590478665049071 -0.8833323446499 2.78561458191715 2.72398333968173 0.323926887852263 0.317105011721314 0.324279642897195 0.590960441491902 NA NA NA 0.642506503884391 99.4766901953356 a6867 gain_cnaBRCA10_(MDM2,NUP107) 192 LFM-A13 BTK 4 44 2.77258872223978 NA 4.57774013857985 4.81526375932402 -0.237523620744174 0.558521015440832 0.856664599845906 0.282614622876702 0.425272486043699 0.277265595878362 0.59100465467205 NA NA NA 0.479448425977459 99.4766901953356 a6868 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1059 AZD8055 MTORC1/2 6 37 0.693147180559945 NA 0.338128087823297 0.0967500816210582 0.241378006202239 1.02451658758312 1.01101627439494 0.238357471197336 0.23560185274468 0.238747893891912 0.591031816089193 NA NA NA 0.609128360814962 99.4766901953356 a6869 gain_cnaBRCA27_(CLTC,PPM1D) 91 KIN001-135 IKKE 3 11 1.6094379124341 NA 3.81972435479286 3.6717239980404 0.148000356752456 0.495123957587999 0.392849088017137 0.359518024962925 0.298915765404366 0.376735905127008 0.591102141824771 NA NA NA 0.668100573892232 99.4766901953356 a6870 BRCA1_mut 1494 SN-38 TOP1 4 44 -2.99573227355399 NA -3.74154949643429 -3.26399205660443 -0.477557439829852 0.993899333485174 1.72909535905251 0.282424653207325 0.480488741405294 0.276189186055961 0.591253353065292 NA NA NA 0.434738808119271 99.4766901953356 a6871 loss_cnaBRCA28_(GPS2) 346 THZ-2-102-1 CDK7 4 44 0.916290731874155 2.99573227355399 -1.99641616689843 -1.27504322702247 -0.72137293987596 1.97117545231945 2.59164646771433 0.282251943202288 0.365960797161477 0.27834542591458 0.591479499118474 NA NA NA 0.533502265195076 99.4766901953356 a6872 loss_cnaBRCA22_(SYNCRIP,ZNF292) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 18 30 2.32630161961136 NA 5.02887730797267 4.91625826077989 0.112619047192781 0.882865561660523 0.563848739908279 0.161132914567437 0.127560811162419 0.199732728339697 0.591489824064425 NA NA NA 0.631767709976012 99.4766901953356 a6873 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 211 TL-2-105 CRAF 9 40 2.32630161961136 1.63315443905142 3.72971720427849 3.94756695627395 -0.217849751995459 0.721631615757463 1.15450906936385 0.199313107348863 0.301884988460203 0.188694708232563 0.591580464810513 NA NA NA 0.479610813574644 99.4766901953356 a6874 PTEN_mut 204 Tipifarnib Farnesyl-transferase (FNTA) 8 40 2.77258872223978 NA 1.35484348090214 1.67300313682116 -0.318159655919022 1.08191461484829 1.58669406294345 0.209215487140281 0.29407094751524 0.200517329300904 0.591670490855377 NA NA NA 0.498233123714958 99.4766901953356 a6875 ARID1A_mut 326 GSK690693 AKT 5 43 2.32630161961136 NA 2.49661513322926 2.99108558972799 -0.494470456498729 1.69433040077386 1.95992049177833 0.255109051242757 0.291838272082522 0.252291079445815 0.591860789080721 NA NA NA 0.568753592807693 99.4766901953356 a6876 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1054 PD-0332991 CDK4, CDK6 5 37 1.38629436111989 0.693147180559945 3.21681749978069 2.83778139217181 0.379036107608883 1.47610116571289 1.47261962154419 0.257328108940423 0.256781930949717 0.25738901075583 0.592144501646765 NA NA NA 0.612367793536882 99.4766901953356 a6877 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 277 ABT-869 VEGFR and PDGFR family 7 41 0.0237165266173161 NA 2.78104915207796 2.67571736184976 0.1053317902282 0.716800613172173 0.430321020189554 0.220573539661392 0.146947126289497 0.244774912882021 0.592243977419532 NA NA NA 0.717485220581914 99.4766901953356 a6878 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 5 42 0.940007258491471 NA 1.60157704525181 1.92283508946223 -0.321258044210418 1.08273745496306 1.27487284533104 0.255172851287759 0.296709089297531 0.251992224469254 0.592283349153303 NA NA NA 0.563684087577215 99.4766901953356 a6879 BRCA2_mut 1036 PLX4720 BRAF 5 38 2.30258509299405 NA 4.87068864633027 4.56055344674602 0.310135199584247 0.607754208118474 1.25608066722295 0.256683031157879 0.510297083000682 0.246907071876141 0.592418968527798 NA NA NA 0.383981985527971 99.4766901953356 a6880 gain_cnaBRCA47_(EGFR) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 6 37 1.6094379124341 NA 2.57492873101117 2.91547736977601 -0.340548638764836 1.29932797001784 1.45204927045444 0.237432670183374 0.262095980863215 0.234529671750228 0.592467367990634 NA NA NA 0.576153778247484 99.4766901953356 a6881 gain_cnaBRCA15 302 PI-103 PI3Ka, PRKDC (DNAPK) 22 26 2.32630161961136 NA 0.970957044609943 1.26168217961572 -0.290725135005776 2.02794199873485 1.71056480968163 0.156121118578228 0.143359689373339 0.169958561850624 0.592528330863251 NA NA NA 0.598086533803175 99.4766901953356 a6882 PIK3CA_mut 11 Paclitaxel Microtubules 4 8 -2.27886856637673 NA -2.68319808159708 -3.29970731129717 0.616509229700087 2.48589686023839 1.44557798411175 0.338522090426752 0.248002738794628 0.426479398881346 0.592538963859572 NA NA NA 0.66995938501512 99.4766901953356 a6883 loss_cnaBRCA18 1039 SL 0101-1 RSK, AURKB, PIM3 12 31 2.30258509299405 NA 4.77691767466155 4.59924539831489 0.177672276346658 0.717224801134036 1.04631881214606 0.183345330091912 0.247721880316649 0.169807017024039 0.592616490104737 NA NA NA 0.530084591271601 99.4766901953356 a6884 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 18 29 -2.30258509299405 NA -0.244552733932411 -0.076087037510879 -0.168465696421532 1.17387977141218 0.952818004407347 0.161697418904135 0.143511883008996 0.176807843305099 0.592628023934877 NA NA NA 0.611661685630539 99.4766901953356 a6885 loss_cnaBRCA23 295 NVP-BHG712 EPHB4 3 46 2.32630161961136 NA 4.25841164912515 3.86246672642817 0.395944922696986 0.217297957183283 1.26059333700219 0.320786337174232 1.82212906108004 0.314094094482985 0.592882267239884 NA NA NA 0.095598013022155 99.4766901953356 a6886 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1052 RO-3306 CDK1 5 38 1.6094379124341 NA 3.79905551449232 3.48970202462089 0.309353489871432 1.03090285904204 1.22472485095995 0.256259985742783 0.300080155135952 0.25259019577251 0.593026960220671 NA NA NA 0.561931599094638 99.4766901953356 a6887 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1013 Nilotinib ABL 5 35 0.693147180559945 NA 2.98584408611013 3.23391642473348 -0.248072338623355 0.926573689583972 0.966971421485796 0.257657492756556 0.267730825310547 0.256545677681126 0.593079209542917 NA NA NA 0.600184780262986 99.4766901953356 a6888 gain_cnaBRCA9_(KRAS) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 42 1.38629436111989 NA 3.24121761309381 2.82217035167141 0.419047261422395 1.06988201203568 1.51424338227464 0.281586192694349 0.391676144386302 0.276737059793464 0.593199279283968 NA NA NA 0.510393327856643 99.4766901953356 a6889 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1 Erlotinib EGFR 3 9 0.693147180559945 NA 3.0869431180298 2.87311575340775 0.213827364622058 0.313243199016348 0.630756845778993 0.367844520623147 0.682624124940373 0.339001258651387 0.593223365373533 NA NA NA 0.464012923220869 99.4766901953356 a6890 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1069 EHT 1864 Rac GTPases 6 40 2.30258509299405 NA 3.73813511611021 3.53491467923056 0.203220436879648 1.2284021143651 0.803920844318482 0.235552261227295 0.165434782717452 0.252786624847285 0.593261274053409 NA NA NA 0.708824573562228 99.4766901953356 a6891 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 275 I-BET BRD2, BRD3, BRD4 6 43 2.99573227355399 NA 3.7581676610532 4.07811874281252 -0.319951081759319 1.31835908742671 1.37064711060447 0.234365534135195 0.24268887347212 0.233430676126561 0.59326564303647 NA NA NA 0.597734455978058 99.4766901953356 a6892 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 6 40 0 NA 1.07702133153872 0.589644217503847 0.487377114034869 2.38080600163355 2.02574675808422 0.23554289098201 0.204710973384838 0.240591333585936 0.593275925268903 NA NA NA 0.650385995985314 99.4766901953356 a6893 gain_cnaBRCA58_(CCND1) 1038 NU-7441 PRKDC (DNAPK) 8 35 0.693147180559945 NA 3.05584936473405 2.85561145017322 0.200237914560829 0.463271341559201 1.0212531320738 0.210889592164527 0.432225990683779 0.196070796036843 0.593386006983775 NA NA NA 0.408105046736248 99.4766901953356 a6894 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1248 FK866 NAMPT 6 38 0 NA -0.0943250595972829 -0.738555472066451 0.644230412469168 2.06866631582909 2.80422657113636 0.236234222740789 0.311423068834071 0.229735506788278 0.593584882235919 NA NA NA 0.520247003099068 99.4766901953356 a6895 gain_cnaBRCA15 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 22 26 2.32630161961136 NA 4.89956982071657 5.0083462811977 -0.108776460481131 0.802774499637108 0.597956905357218 0.155629197622337 0.135500642497119 0.181913545117684 0.59369115582336 NA NA NA 0.603099743631659 99.4766901953356 a6896 gain_cnaBRCA9_(KRAS) 328 SNX-2112 HSP90 4 44 0.940007258491471 NA -0.109275313368726 0.465104981316494 -0.57438029468522 1.97864595835553 2.05375484989631 0.280330410091247 0.290289575181298 0.279673250541183 0.593998314428442 NA NA NA 0.612000793342678 99.4766901953356 a6897 gain_cnaBRCA64_(SDHC) 196 Phenformin AAPK1 (AMPK) agonist 8 40 8.29404964010203 NA 7.51725292392294 7.13896511607595 0.378287807846991 2.66287294911944 1.62253339085972 0.207892869876289 0.142060028801631 0.233146393151608 0.594008446314305 NA NA NA 0.708284205797936 99.4766901953356 a6898 CDH1_mut 1230 IOX2 EGLN1 5 42 -2.30258509299405 NA 0.100471057944044 0.267199814019429 -0.166728756075385 0.570783382768153 0.664584722850772 0.25385416389958 0.292105133241254 0.250876600593816 0.594191840543616 NA NA NA 0.569115402294675 99.4766901953356 a6899 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 306 TG101348 JAK2 9 39 2.32630161961136 NA 3.01715372008049 3.27282782663635 -0.25567410655586 0.656083258760337 1.38572702825674 0.198373203409606 0.389697653677299 0.184505390558414 0.594243863571138 NA NA NA 0.419049217948656 99.4766901953356 a6900 loss_cnaBRCA7_(FAS,PTEN) 1203 QL-XII-61 BTK 3 20 2.30258509299405 NA 4.66911358757544 4.15862565564383 0.510487931931614 0.692047966768889 1.58686911116798 0.334867385868313 0.737648192675195 0.321695046137662 0.594295600137511 NA NA NA 0.376277852802338 99.4766901953356 a6901 gain_cnaBRCA12_(TERT) 1166 QL-VIII-58 MTOR, ATR 5 21 2.30258509299405 NA -1.27361729043284 -1.57745797423707 0.303840683804226 1.75489364070677 0.95925938394009 0.268550239845628 0.173139087609809 0.316745073221199 0.59439249562823 NA NA NA 0.725018742598545 99.4766901953356 a6902 loss_cnaBRCA7_(FAS,PTEN) 272 AR-42 HDAC 4 45 1.63315443905142 NA 0.536456179816615 0.106903059463226 0.429553120353389 1.55775086804374 1.53527632589892 0.279525825787388 0.275752130308766 0.279788799649393 0.594659448840175 NA NA NA 0.628141818821538 99.4766901953356 a6903 loss_cnaBRCA28_(GPS2) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 4 44 2.32630161961136 NA 4.77920459017821 4.97478911377709 -0.195584523598878 0.794123898226252 0.691830025741078 0.279823055545147 0.246289683556601 0.28270603518454 0.59466421796468 NA NA NA 0.66253049637403 99.4766901953356 a6904 loss_cnaBRCA18 64 CMK RSK 5 7 1.38629436111989 NA 1.97369757445134 2.36876997699136 -0.395072402540013 1.23459685816814 1.22312430223928 0.321791948362686 0.32000114039348 0.323002659514426 0.59467763042831 NA NA NA 0.597030369883987 99.4766901953356 a6905 loss_cnaBRCA34 310 YM201636 FYV1 5 44 1.63315443905142 NA 2.64650700022648 2.38832208420546 0.258184916021027 0.728856382028136 1.04450337599714 0.252764549343845 0.354232908412758 0.247184376761394 0.59476999303865 NA NA NA 0.502260045004177 99.4766901953356 a6906 gain_cnaBRCA47_(EGFR) 1023 GW 441756 NTRK1 7 38 0.693147180559945 NA 2.60263079425244 2.3144602639604 0.288170530292039 1.62638475741323 1.24859714797889 0.220334196206237 0.177184721498728 0.230795441715129 0.594930480625872 NA NA NA 0.668949623288804 99.4766901953356 a6907 gain_cnaBRCA10_(MDM2,NUP107) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 5 44 3.68887945411394 NA 3.73177800535933 3.42851323178292 0.303264773576411 0.995346116944554 1.21774307814502 0.252632047927415 0.304682731377255 0.249038388326027 0.594962557388312 NA NA NA 0.554217844243793 99.4766901953356 a6908 PIK3CA_mut 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 16 29 2.30258509299405 NA 1.48438493065171 1.29963523446409 0.184749696187611 0.986116404645339 1.16740980251126 0.166810330179857 0.187350798868473 0.158256077506106 0.594964959429583 NA NA NA 0.577105469753275 99.4766901953356 a6909 ARID1A_mut 1053 MK-2206 AKT1, AKT2 4 38 1.38629436111989 0.693147180559945 0.972539596231692 1.43823057459361 -0.465690978361917 2.27498622172113 1.59217361979873 0.281691291308574 0.204700570893831 0.292487560760356 0.595006441335837 NA NA NA 0.714055013864222 99.4766901953356 a6910 gain_cnaBRCA12_(TERT) 1028 VX-702 p38 10 35 0.693147180559945 NA 3.5294386775136 3.39751507588806 0.131923601625545 0.640374345547983 0.698873344439347 0.192016889894147 0.206010129141971 0.188766108587784 0.595056639329414 NA NA NA 0.581583355337643 99.4766901953356 a6911 ARID1A_mut 1502 Bicalutamide ANDR (androgen receptor) 5 40 2.30258509299405 NA 4.42593461391774 4.57484919782785 -0.148914583910103 0.611454686696177 0.583643540687886 0.253996365196084 0.243541487456284 0.255146461030977 0.595082796608671 NA NA NA 0.628048909927575 99.4766901953356 a6912 loss_cnaBRCA36_(FAT1,IRF2) 1050 ZM-447439 AURKB 8 31 1.38629436111989 0.693147180559945 3.11164869759033 2.83018869677682 0.281460000813519 1.01905722103887 1.38591425986464 0.212530691023076 0.276196463753614 0.203086156888961 0.595208290903604 NA NA NA 0.530429586804112 99.4766901953356 a6913 loss_cnaBRCA18 288 KIN001-055 JAK3, MNK1 16 33 2.32630161961136 NA 4.24473499537237 4.38471462320236 -0.139979627829992 0.915448512783184 0.831202047346902 0.162958885882272 0.15290824756973 0.168406259677524 0.595220168055834 NA NA NA 0.609329644395116 99.4766901953356 a6914 loss_cnaBRCA29_(MAP2K4) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 7 39 0 NA 0.267907712986622 0.722372889704611 -0.454465176717989 3.30240489494802 1.79884336871507 0.219629084686308 0.13761643141131 0.252642995283473 0.595310981679029 NA NA NA 0.733736572701586 99.4766901953356 a6915 loss_cnaBRCA20 255 CP724714 ERBB2 3 45 2.32630161961136 NA 4.30407546716789 3.7696330330897 0.534442434078191 0.738380505049276 1.70646131145495 0.318872374197087 0.723803554432311 0.313187548109437 0.595387835328349 NA NA NA 0.347514093340466 99.4766901953356 a6916 loss_cnaBRCA29_(MAP2K4) 258 STF-62247 stimulates autophagy 7 42 2.32630161961136 NA 4.81147040537715 4.60073832204961 0.210732083327545 0.908174334807084 0.973637710206186 0.218255830114176 0.232039240981534 0.21643788148152 0.595436021302002 NA NA NA 0.588403747620253 99.4766901953356 a6917 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1494 SN-38 TOP1 6 42 -2.99573227355399 NA -2.95849666657382 -3.35311591611641 0.394619249542597 1.6624320736043 1.69449553313116 0.233358933319904 0.237374660780592 0.23288302732401 0.595437736822755 NA NA NA 0.605310289813985 99.4766901953356 a6918 gain_cnaBRCA47_(EGFR) 1006 Cytarabine DNA synthesis 7 38 0.693147180559945 NA 0.923234662961113 1.26108828223687 -0.337853619275758 1.6929201246068 1.50868690058961 0.21999670815728 0.199568552801171 0.223938856461021 0.595492891462764 NA NA NA 0.635383108256192 99.4766901953356 a6919 loss_cnaBRCA7_(FAS,PTEN) 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 3 23 2.30258509299405 NA 4.97835674923285 4.64763112166946 0.330725627563396 0.693731221396529 1.02476328549649 0.330274550580363 0.476734529689499 0.322733681274658 0.595505692889392 NA NA NA 0.514898835511273 99.4766901953356 a6920 gain_cnaBRCA14_(RAD21) 135 Gemcitabine DNA replication 20 27 0.0237165266173161 NA -0.023691310018901 -0.461544040635286 0.437852730616385 2.8059837841938 2.75389682448155 0.157727456852817 0.156042502128068 0.158993876140881 0.595535987945801 NA NA NA 0.596859917241019 99.4766901953356 a6921 loss_cnaBRCA7_(FAS,PTEN) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 4 43 2.77258872223978 NA 5.27411019272621 4.98641695177161 0.287693240954598 0.900809664511149 1.03803364142084 0.279461803332681 0.31937184101008 0.277152135995139 0.595550765066228 NA NA NA 0.581019979871018 99.4766901953356 a6922 loss_cnaBRCA29_(MAP2K4) 207 AS601245 JNK 7 41 2.07944154167984 NA 2.50681203246051 2.22512073180488 0.281691300655632 0.933046409010344 1.33444927160045 0.21850090732718 0.301904919128743 0.211091801427408 0.595716817594213 NA NA NA 0.506262113301127 99.4766901953356 a6923 loss_cnaBRCA29_(MAP2K4) 1030 KU-55933 ATM 5 37 2.30258509299405 NA 4.01429273887536 4.25040835723336 -0.236115618358007 0.357452920939856 0.96988452040274 0.254701010595113 0.660550255785253 0.243447145913785 0.595917056345708 NA NA NA 0.312978531213143 99.4766901953356 a6924 loss_cnaBRCA28_(GPS2) 1038 NU-7441 PRKDC (DNAPK) 3 40 0.693147180559945 NA 3.17529095465247 2.87168307024944 0.303607884403033 0.882975463374235 0.952829343957073 0.319741709174534 0.343846343411191 0.318638260175907 0.596128732015699 NA NA NA 0.617583789113886 99.4766901953356 a6925 gain_cnaBRCA47_(EGFR) 1061 SB590885 BRAF 6 36 1.6094379124341 NA 4.23265091130692 3.97512182726612 0.257529084040799 0.728617931799744 1.13610789202453 0.235507342618494 0.353448731909029 0.226676608664241 0.596241854796476 NA NA NA 0.482536368333021 99.4766901953356 a6926 ASH1L_mut 1001 AICAR AAPK1 (AMPK) agonist 3 42 7.60090245954208 NA 8.15132190899992 7.70899482332114 0.442327085678782 0.730889198453095 1.41161396097567 0.318822234479465 0.60519034432983 0.31334847763411 0.596440337447909 NA NA NA 0.416469853031558 99.4766901953356 a6927 loss_cnaBRCA60 184 BMS-754807 IGF1R 3 45 0.940007258491471 NA 2.12919924158732 1.59338026888605 0.535818972701275 0.72959385760006 1.71699803381809 0.31777955264348 0.734407187121624 0.312067318743385 0.596645715750665 NA NA NA 0.342262068299672 99.4766901953356 a6928 BRCA1_mut 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 4 43 2.32630161961136 NA 1.80940133897053 1.380427898134 0.428973440836532 2.07780198397674 1.49389543551614 0.278603561076639 0.206455400536057 0.287150914741446 0.596677456507487 NA NA NA 0.711472450210056 99.4766901953356 a6929 loss_cnaBRCA34 1268 XAV 939 TNKS1 (tankyrase-1) 5 42 1.6094379124341 NA 3.448923784272 3.6867425549933 -0.237818770721299 0.772792521945615 0.958611525762861 0.252039533490558 0.307739482419623 0.248086700743602 0.596822834991913 NA NA NA 0.551997387511144 99.4766901953356 a6930 loss_cnaBRCA33 1219 PFI-1 BRD2, BRD3, BRD4 5 42 2.30258509299405 NA 2.94678992418927 3.19934905508551 -0.252559130896244 0.5497485804412 1.03614102944447 0.251927273552927 0.459408427564385 0.243749763515933 0.596985778168095 NA NA NA 0.414322831965111 99.4766901953356 a6931 loss_cnaBRCA57 1264 SGC0946 Q8TEK3 (DOT1L) 5 41 -0.693147180559945 NA 1.81367408935349 1.96742580648789 -0.153751717134405 0.777101294566428 0.590478037486161 0.252131176421377 0.197852864497141 0.260385158081359 0.597222988294979 NA NA NA 0.688280467210244 99.4766901953356 a6932 loss_cnaBRCA60 1378 Bleomycin (50 uM) DNA damage 3 45 3.91202300542815 NA 4.3760685993204 3.77516088076066 0.600907718559737 2.04671356587794 1.88728565958206 0.317186006740567 0.293596392078429 0.318397861769801 0.597329433609166 NA NA NA 0.665253404232111 99.4766901953356 a6933 TP53_mut 290 KIN001-260 IKK 38 11 2.99573227355399 NA 5.08685177537853 4.89629460465301 0.190557170725521 1.10338596572569 0.801731397743006 0.18208795510335 0.17270218821407 0.237682060677638 0.597350033871319 NA NA NA 0.532869298342264 99.4766901953356 a6934 NF1_mut 271 VNLG/124 HDAC, RAR 5 44 1.63315443905142 NA 4.33550400459571 4.13052375347556 0.20498025112015 0.592595429867249 0.834581710468834 0.250960466876406 0.345902517618248 0.245608367100449 0.597394386324569 NA NA NA 0.51098226232832 99.4766901953356 a6935 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1032 Afatinib ERBB2, EGFR 7 38 -0.693147180559945 NA -0.0496012704134396 0.353116718965141 -0.402717989378581 1.74313316766539 1.85595940809319 0.218793388127176 0.23103110929726 0.216986420943513 0.597500218676234 NA NA NA 0.592241985065657 99.4766901953356 a6936 loss_cnaBRCA20 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 3 45 2.32630161961136 NA 4.75077432673453 4.97233814192669 -0.221563815192155 0.640312194709467 0.701542644985297 0.316976185112665 0.346024668939324 0.315823730425966 0.597571219501531 NA NA NA 0.614977486049837 99.4766901953356 a6937 loss_cnaBRCA34 1018 ABT-888 PARP1, PARP2 5 40 1.6094379124341 NA 4.25337896168544 4.42178834581399 -0.168409384128558 0.387623932376999 0.689897793248955 0.252269143268258 0.434465908995434 0.24410772983555 0.597580855429094 NA NA NA 0.435744240797414 99.4766901953356 a6938 loss_cnaBRCA18 1053 MK-2206 AKT1, AKT2 12 30 1.38629436111989 0.693147180559945 1.60849652024027 1.30803206588669 0.300464454353578 1.99893590033128 1.50149528535012 0.181738431640973 0.150312200758305 0.200110155046884 0.597616757541384 NA NA NA 0.644390396318918 99.4766901953356 a6939 gain_cnaBRCA15 1114 Cetuximab EGFR 20 25 4.18661983833127 NA 6.3607503363859 6.22005283013082 0.140697506255075 0.556538266180184 1.07165230178713 0.159528713622272 0.252808323892545 0.131290257129522 0.597627327399982 NA NA NA 0.573622320687191 99.4766901953356 a6940 loss_cnaBRCA42 185 OSI-906 IGF1R 3 45 0.940007258491471 NA 3.2300301780648 2.8710538948988 0.358976283165997 0.225759482161217 1.15745266576469 0.316839932963989 1.59008286043839 0.310143381050346 0.59772825292654 NA NA NA 0.120288949415219 99.4766901953356 a6941 loss_cnaBRCA24 179 5-Fluorouracil DNA antimetabolite 3 46 3.46573590279973 NA 3.55867122769405 4.07296400068612 -0.514292772992068 1.18774097949207 1.64214448815167 0.316410346619349 0.4330007820493 0.313183630735768 0.597921245830568 NA NA NA 0.539011708518783 99.4766901953356 a6942 loss_cnaBRCA38 1239 YK 4-279 RNA helicase A 3 39 2.30258509299405 NA 1.62892872095812 2.04313935393331 -0.414210632975185 1.30536796194267 1.3010699422347 0.318308883573227 0.317313313219937 0.318361541935049 0.598168221746835 NA NA NA 0.642744180147358 99.4766901953356 a6943 gain_cnaBRCA10_(MDM2,NUP107) 1017 Olaparib PARP1, PARP2 3 42 1.6094379124341 NA 4.33876318492185 4.05519344873893 0.283569736182915 0.356884940673825 0.911862254670901 0.317290025959354 0.794569072170751 0.310978697418787 0.598200617572767 NA NA NA 0.3156637163302 99.4766901953356 a6944 gain_cnaBRCA27_(CLTC,PPM1D) 1161 ZG-10 IRAK1 7 19 2.30258509299405 NA 1.73144311362262 2.06529335381509 -0.33385024019247 1.00582967553752 1.52593930410634 0.236109599030927 0.33191528179367 0.218783433452478 0.598243826631587 NA NA NA 0.527148899156312 99.4766901953356 a6945 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1377 Afatinib (rescreen) ERBB2, EGFR 6 41 2.30258509299405 NA 2.43055139777168 2.89377506642675 -0.463223668655075 2.13583970811972 1.97928365254816 0.231926690500058 0.216881288841134 0.234036020081666 0.598303173804754 NA NA NA 0.633521714049056 99.4766901953356 a6946 TP53_mut 294 MPS-1-IN-1 MPS1 38 11 2.99573227355399 NA 4.8045168676535 4.59070240672021 0.213814460933284 1.19574654594584 1.10768209499327 0.181573981536514 0.178812526499213 0.193028723583893 0.598382081915996 NA NA NA 0.586914199376349 99.4766901953356 a6947 loss_cnaBRCA17 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 6 37 1.6094379124341 NA 3.15631327952659 2.82119879434108 0.335114485185512 1.33401262025754 1.44785635153659 0.233617693401157 0.251207882216898 0.231455617009145 0.598406747170657 NA NA NA 0.590328916839483 99.4766901953356 a6948 ARID1A_mut 1030 KU-55933 ATM 4 38 2.30258509299405 NA 3.98824058075178 4.24693712076327 -0.258696540011492 0.876061843220223 0.931089741691015 0.27904567984638 0.295294837931277 0.277842756103891 0.598457516779497 NA NA NA 0.608251270622399 99.4766901953356 a6949 BRCA2_mut 310 YM201636 FYV1 6 43 1.63315443905142 NA 2.20758647191157 2.44356250871403 -0.235976036802453 0.848046380027976 1.04023300488271 0.23100758113064 0.278258409398161 0.226849211373621 0.598554787339989 NA NA NA 0.554380413344868 99.4766901953356 a6950 PIK3CA_mut 1003 Camptothecin TOP1 16 29 -2.30258509299405 NA -2.35939346291103 -2.62301274395677 0.263619281045736 1.54318100285434 1.62380463769975 0.165160220340824 0.170828490344381 0.162346673316055 0.598601310449262 NA NA NA 0.593990251505753 99.4766901953356 a6951 loss_cnaBRCA20 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 43 1.38629436111989 NA 3.29913354908674 2.82787499012359 0.471258558963145 0.233990871275081 1.52247616576918 0.316640403458945 2.01400403526482 0.309534276830573 0.59860325930056 NA NA NA 0.0932316038642839 99.4766901953356 a6952 gain_cnaBRCA27_(CLTC,PPM1D) 1008 Methotrexate Dihydrofolate reductase (DHFR) 10 35 -1.6094379124341 NA 0.844585501288561 0.636382809637091 0.20820269165147 0.922107823700539 1.13620819343456 0.190162648054944 0.22578996327775 0.183243434481942 0.598605679024152 NA NA NA 0.558560176316279 99.4766901953356 a6953 gain_cnaBRCA30_(CRNKL1,FOXA2) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 5 43 0.246860077931526 2.32630161961136 0.107677379747483 -0.308280854050686 0.415958233798169 1.87422089743072 1.63908474956702 0.250448493205715 0.221936610763643 0.2537746958527 0.598626479249214 NA NA NA 0.655487415368002 99.4766901953356 a6954 POLR2B_mut 341 EX-527 SIRT1 3 46 2.99573227355399 NA 5.44685053923062 5.65446428441577 -0.20761374518515 0.649468138396723 0.657810048882647 0.315782891526661 0.3196673291744 0.31561352025224 0.598645406984595 NA NA NA 0.639756472461998 99.4766901953356 a6955 TP53_mut 1003 Camptothecin TOP1 35 10 -2.30258509299405 NA -2.46190133977516 -2.76511180891922 0.303210469144053 1.52475858682223 1.84104946887104 0.189963202454237 0.198858017108124 0.164694362791884 0.598988011559789 NA NA NA 0.641971093397183 99.4766901953356 a6956 gain_cnaBRCA12_(TERT) 1072 BMS-708163 g-secretase 10 36 1.6094379124341 NA 3.8264214409693 3.64475763778469 0.18166380318461 0.833961044453395 0.989146556403049 0.189341951777116 0.217832480776939 0.18365711532699 0.598991787644021 NA NA NA 0.566930654605253 99.4766901953356 a6957 gain_cnaBRCA47_(EGFR) 177 GSK-650394 SGK3 6 41 2.77258872223978 NA 4.35838305498719 3.96410550726961 0.394277547717574 1.37015830167722 1.74099407627203 0.231413325404577 0.287760580098618 0.226466909388822 0.599110800248559 NA NA NA 0.544747561849889 99.4766901953356 a6958 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1067 CCT007093 PPM1D 8 38 1.88706964903238 NA 4.25411379674062 4.05016726120429 0.20394653553633 0.595663409809504 1.04839922789953 0.205940903185705 0.342385535484802 0.194531367544917 0.599175169778701 NA NA NA 0.461114824831015 99.4766901953356 a6959 MLL3_mut 1194 SB-505124 TGFR1 (ALK5) 3 44 2.30258509299405 NA 4.11633724527397 4.4075896695158 -0.291252424241822 0.491920226909565 0.937542498543942 0.315782285328749 0.592072470919896 0.310655169972726 0.599262711329568 NA NA NA 0.424199816704403 99.4766901953356 a6960 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 8 37 2.30258509299405 NA 1.55326721177656 1.32468764853172 0.228579563244842 1.13553310416158 1.10212266471696 0.20636811153772 0.201297137359649 0.207399385352033 0.599335971005534 NA NA NA 0.615016993997398 99.4766901953356 a6961 ARID1A_mut 290 KIN001-260 IKK 5 44 2.99573227355399 NA 4.80952748385957 5.0707266067334 -0.261199122873824 0.84147933873933 1.06361463433335 0.249581903755257 0.310404677630163 0.245576841877076 0.599403433416451 NA NA NA 0.548470578944685 99.4766901953356 a6962 gain_cnaBRCA12_(TERT) 134 Etoposide TOP2 9 38 2.77258872223978 NA 2.8206338482474 2.39573881897047 0.424895029276937 1.3619195802985 2.30677130705266 0.195886326158129 0.311982466089379 0.184194691505774 0.599813636448928 NA NA NA 0.478314186845836 99.4766901953356 a6963 gain_cnaBRCA31 1219 PFI-1 BRD2, BRD3, BRD4 15 32 2.30258509299405 NA 3.05964816372819 3.22537148370672 -0.165723319978529 1.0016375886715 1.00297360591527 0.165300457127663 0.165452377040216 0.165231985170036 0.599916206481634 NA NA NA 0.601378402362797 99.4766901953356 a6964 POLR2B_mut 344 THZ-2-49 CDK9 3 46 2.99573227355399 NA 2.22218910769396 1.75678059674578 0.465408510948185 0.409420595831819 1.51047686986962 0.31438007188956 1.13674914180274 0.308120250122305 0.600265918654181 NA NA NA 0.19564399873867 99.4766901953356 a6965 loss_cnaBRCA24 135 Gemcitabine DNA replication 3 44 0.0237165266173161 NA -1.09368460860967 -0.219419578902312 -0.874265029707358 2.55855571454074 2.78594315763977 0.314910589378763 0.341702556930361 0.313812946007136 0.600268085830646 NA NA NA 0.619191647647858 99.4766901953356 a6966 loss_cnaBRCA60 179 5-Fluorouracil DNA antimetabolite 3 46 3.46573590279973 NA 3.56193816839179 4.07275093933627 -0.510812770944484 1.19084308245346 1.64211261658909 0.314256618068015 0.42895052964667 0.311070486752313 0.600408628243948 NA NA NA 0.542459651431928 99.4766901953356 a6967 loss_cnaBRCA57 1199 Tamoxifen ER 5 42 1.6094379124341 NA 4.08267615298389 3.84375284959208 0.238923303391811 0.641810419176546 0.982932209664431 0.24951680538413 0.372264606888673 0.24307200541671 0.600489562913675 NA NA NA 0.487461257617245 99.4766901953356 a6968 loss_cnaBRCA38 255 CP724714 ERBB2 4 44 2.32630161961136 NA 4.22608848623384 3.76457633967284 0.461512146561003 0.632988550928106 1.7255884866761 0.275335071832945 0.729100306607948 0.267452031654422 0.600569983699173 NA NA NA 0.291977825347336 99.4766901953356 a6969 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 254 AC220 FLT3 7 41 0.0237165266173161 NA 2.387056267701 2.19588237053084 0.191173897170162 0.594168266331582 0.923262505243153 0.215459026562861 0.32175043334185 0.207063425715327 0.60083099823641 NA NA NA 0.487875138697998 99.4766901953356 a6970 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1243 piperlongumine Increases ROS levels 9 38 2.30258509299405 NA 1.5749064868829 1.74230154563006 -0.167395058747164 0.932589532202418 0.840427583403799 0.195204667027058 0.179494893484212 0.199178444464187 0.601079790944822 NA NA NA 0.631369075528067 99.4766901953356 a6971 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1067 CCT007093 PPM1D 18 28 1.88706964903238 NA 3.98973176476848 4.14728909049483 -0.157557325726344 1.14553894429951 0.878685957062585 0.159092722101147 0.137539912117689 0.179310167028335 0.601111332238833 NA NA NA 0.622820242053318 99.4766901953356 a6972 gain_cnaBRCA19 282 EKB-569 EGFR 4 43 0.916290731874155 2.99573227355399 1.04292120308881 1.62784849847671 -0.584927295387907 2.8795720656057 2.0613542341915 0.275166284270865 0.203129938081571 0.283758747373824 0.601199897696984 NA NA NA 0.715781634387501 99.4766901953356 a6973 gain_cnaBRCA64_(SDHC) 135 Gemcitabine DNA replication 7 40 0.0237165266173161 NA 0.234340011421814 -0.364397384437086 0.598737395858901 3.43200010631589 2.66109321254862 0.215662015931315 0.174457277771364 0.224996776901877 0.601205548423676 NA NA NA 0.673299356751849 99.4766901953356 a6974 loss_cnaBRCA29_(MAP2K4) 1043 JNK Inhibitor VIII JNK 5 38 2.30258509299405 NA 4.63131284103952 4.81917569961553 -0.18786285857601 0.674078254508475 0.757524386561865 0.250553219626638 0.278695918937478 0.247995789849952 0.601257421849359 NA NA NA 0.587017845206949 99.4766901953356 a6975 gain_cnaBRCA64_(SDHC) 287 KIN001-244 PDPK1 (PDK1) 8 41 2.99573227355399 NA 3.63922439551474 3.44666831431425 0.192556081200493 1.10551626096435 0.916426261245849 0.203336033833486 0.174177520493932 0.210116284684727 0.601305165408501 NA NA NA 0.654655281983345 99.4766901953356 a6976 loss_cnaBRCA20 1018 ABT-888 PARP1, PARP2 3 42 1.6094379124341 NA 4.20708002720004 4.41707591808064 -0.209995890880604 0.196608855006625 0.682332365408525 0.314542578969706 1.06808968941672 0.307761878999944 0.601363125081782 NA NA NA 0.219036161278974 99.4766901953356 a6977 PIK3CA_mut 1175 AG-014699 PARP1, PARP2 15 28 1.6094379124341 NA 3.74840675384899 3.92219416357297 -0.173787409723982 1.25951733820637 0.890938483570249 0.168446458807264 0.137979370709947 0.195061065302248 0.601416214144464 NA NA NA 0.639840933579256 99.4766901953356 a6978 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 18 28 1.38629436111989 NA 3.0025899881868 2.76605019411472 0.236539794072073 1.31393567093863 1.58842145146301 0.158924011809373 0.180023877350935 0.148915008579246 0.601496032064465 NA NA NA 0.58636323691967 99.4766901953356 a6979 gain_cnaBRCA48 1066 AZD6482 PI3Kbeta 5 38 1.6094379124341 NA 1.64730511793236 2.0092774432489 -0.361972325316541 0.780122376624835 1.50018504224261 0.250359720500918 0.46399428623314 0.241285118251434 0.60153742703655 NA NA NA 0.417809997558337 99.4766901953356 a6980 loss_cnaBRCA29_(MAP2K4) 1243 piperlongumine Increases ROS levels 7 40 2.30258509299405 NA 1.86740354708624 1.68274480715712 0.184658739929121 0.459813791839194 0.903323707014921 0.215333930845142 0.401594608962274 0.204421447699336 0.601757398472077 NA NA NA 0.423977556025673 99.4766901953356 a6981 loss_cnaBRCA38 1502 Bicalutamide ANDR (androgen receptor) 3 42 2.30258509299405 NA 4.73024149436716 4.54602182141908 0.184219672948082 0.287244334900037 0.597126757983516 0.314176973678663 0.641334399204744 0.308510162180954 0.601784551172438 NA NA NA 0.395273114058223 99.4766901953356 a6982 loss_cnaBRCA20 302 PI-103 PI3Ka, PRKDC (DNAPK) 3 45 2.32630161961136 NA 0.581366114960623 1.16490429570101 -0.583538180740391 0.741308376587451 1.89775437293715 0.313314841707403 0.787173326472659 0.307488782037294 0.601797707647501 NA NA NA 0.317524736399606 99.4766901953356 a6983 loss_cnaBRCA38 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 4 42 1.63315443905142 NA 1.53492195340897 1.97484954719528 -0.439927593786304 0.186152963265966 1.6565216973571 0.274990650238204 2.36325861306735 0.265573094809556 0.601856609919792 NA NA NA 0.113245273928591 99.4766901953356 a6984 loss_cnaBRCA42 202 GSK-1904529A IGF1R 3 45 0.0237165266173161 NA 2.4353185896325 2.17329814725399 0.262020442378509 0.264938904686425 0.853606805861419 0.313170697743735 0.988984395057531 0.306956833731065 0.601964385447297 NA NA NA 0.239163323578676 99.4766901953356 a6985 BRCA1_mut 312 AV-951 VEGFR 4 44 -2.05572501506252 NA 0.794333054252744 0.617543375159042 0.176789679093702 0.326790412737617 0.661059887020158 0.274277233704622 0.54098796109924 0.267433681221549 0.601965977856491 NA NA NA 0.393738100473988 99.4766901953356 a6986 loss_cnaBRCA38 1038 NU-7441 PRKDC (DNAPK) 3 40 0.693147180559945 NA 2.6149037621942 2.91371210968381 -0.298808347489605 0.37161791458944 0.970046614998387 0.314652785235014 0.80407411956909 0.308035039625495 0.60197028116541 NA NA NA 0.313883844399969 99.4766901953356 a6987 loss_cnaBRCA38 1005 Cisplatin DNA crosslinker 3 42 1.79175946922805 2.30258509299405 4.01836346640445 3.64520641481342 0.373157051591037 1.19938809723396 1.18789283148228 0.313991622543836 0.311122857106566 0.314133600019628 0.601998254468592 NA NA NA 0.648469894741077 99.4766901953356 a6988 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 140 Vinorelbine Microtubules 6 41 -2.74887219562247 NA -3.93105722011945 -3.55134295411066 -0.379714266008789 1.40522508311668 1.6824728978292 0.229578286965503 0.270215975056901 0.225688191767436 0.602001851201042 NA NA NA 0.565593071613296 99.4766901953356 a6989 TP53_mut 1042 BIRB 0796 p38, JNK2 34 9 2.30258509299405 NA 4.32831215927968 4.51122171474044 -0.18290955546076 1.0184079058831 0.374986264860822 0.196982361218653 0.179603432381205 0.487776680376939 0.60208209299136 NA NA NA 0.40001054615163 99.4766901953356 a6990 gain_cnaBRCA15 1049 PD-173074 FGFR1, FGFR3 20 23 0.693147180559945 NA 2.83912293000706 3.02353882458805 -0.184415894580984 1.37510360175774 0.908661749631372 0.160555054425353 0.134110545812877 0.202953293297311 0.602319679899262 NA NA NA 0.613113649021353 99.4766901953356 a6991 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1494 SN-38 TOP1 10 38 -2.99573227355399 NA -3.05413635611437 -3.36948644513654 0.315350089022174 1.6182492992917 1.70851618084682 0.186461490602255 0.194871142017612 0.184575418458063 0.602353704085372 NA NA NA 0.596004419661969 99.4766901953356 a6992 PTEN_mut 346 THZ-2-102-1 CDK7 8 40 0.916290731874155 2.99573227355399 -1.76793129096738 -1.24860290822108 -0.519328382746303 2.58513086962315 2.55102533630333 0.203160671714391 0.20089055793992 0.2035763327615 0.602408962135988 NA NA NA 0.614575377029748 99.4766901953356 a6993 loss_cnaBRCA36_(FAT1,IRF2) 1042 BIRB 0796 p38, JNK2 9 34 2.30258509299405 NA 4.22210102010592 4.4048441078594 -0.182743087753485 0.940164964319931 0.925729415014807 0.196801879995207 0.194373428801053 0.197404430268171 0.602413750631343 NA NA NA 0.61207506773749 99.4766901953356 a6994 loss_cnaBRCA57 1143 HG-5-88-01 EGFR, ADCK4 5 21 2.30258509299405 NA 4.32469956037652 4.5839288299608 -0.259229269584279 1.30231769568537 0.910761000661205 0.262678571934762 0.199052251568965 0.284629303841601 0.602431786823268 NA NA NA 0.691166039824977 99.4766901953356 a6995 gain_cnaBRCA48 1024 CEP-701 FLT3, JAK2, NTRK1, RET 5 40 0.693147180559945 NA 0.306559464662047 0.665445104567413 -0.358885639905365 0.368451229021038 1.51034437185002 0.248748585470012 0.974038384561537 0.23761841775579 0.602687809982057 NA NA NA 0.22696700380038 99.4766901953356 a6996 TP53_mut 152 CP466722 ATM 38 11 2.77258872223978 NA 2.77308010356402 2.58180930343198 0.191270800132046 1.04715602892082 1.1334788993915 0.179410320663827 0.182657402382686 0.168746679126297 0.60273579783432 NA NA NA 0.623383254887066 99.4766901953356 a6997 gain_cnaBRCA9_(KRAS) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 4 43 0.940007258491471 NA 2.20407231196921 1.85931790083246 0.344754411136746 0.706830340230942 1.2896470665403 0.273785606564656 0.487747046942134 0.267324619332953 0.603020954600678 NA NA NA 0.432113567109429 99.4766901953356 a6998 gain_cnaBRCA10_(MDM2,NUP107) 1020 Lenalidomide TNFA 3 42 1.6094379124341 NA 4.46327919982465 4.23982996095982 0.223449238864827 0.2974405588368 0.728029036903155 0.313048445156361 0.751239977959526 0.30692352576392 0.60308625283223 NA NA NA 0.336821866414453 99.4766901953356 a6999 loss_cnaBRCA7_(FAS,PTEN) 1230 IOX2 EGLN1 4 43 -2.30258509299405 NA 0.41393552833495 0.234162915469685 0.179772612865265 0.289352550181941 0.675533688974511 0.273672355091118 0.621292650616789 0.266119389453645 0.603170442409055 NA NA NA 0.346639967620621 99.4766901953356 a7000 gain_cnaBRCA15 277 ABT-869 VEGFR and PDGFR family 22 26 0.0237165266173161 NA 2.65186183387143 2.72426136750825 -0.0723995336368257 0.464565269710465 0.488323717121141 0.151582663757201 0.155843620600283 0.148261350203609 0.603297210522998 NA NA NA 0.601799237532666 99.4766901953356 a7001 gain_cnaBRCA61_(NOTCH2) 282 EKB-569 EGFR 3 44 0.916290731874155 2.99573227355399 2.19945302597874 1.53570025383904 0.663752772139699 0.623137108282662 2.17051899935671 0.312236687681165 1.06517933744786 0.305803714381868 0.603356950287884 NA NA NA 0.217848475187705 99.4766901953356 a7002 loss_cnaBRCA17 176 IPA-3 PAK1, PAK2, PAK3 11 36 3.46573590279973 NA 4.70612186162331 4.43289204645321 0.273229815170103 1.31623496213377 1.56908277447067 0.180166346715835 0.207584377433012 0.174133461673032 0.603564480315275 NA NA NA 0.571935599676869 99.4766901953356 a7003 gain_cnaBRCA12_(TERT) 1033 Vismodegib SMO 10 35 2.30258509299405 NA 4.87443228205119 4.72701522329065 0.147417058760539 0.888064318050031 0.756999204649693 0.187495921807248 0.165998178019618 0.194738723442593 0.60372717808303 NA NA NA 0.640820563819882 99.4766901953356 a7004 CDH1_mut 153 Midostaurin KIT 4 43 -0.669430653942629 NA 0.97775841859035 0.578177147895083 0.399581270695267 1.29680109695168 1.4735207743454 0.273235899158925 0.30812841817804 0.271174507785802 0.603746709390484 NA NA NA 0.593495656679613 99.4766901953356 a7005 loss_cnaBRCA20 228 KIN001-102 AKT1 3 46 2.32630161961136 NA 2.35669470542684 1.91676939319011 0.439925312236728 0.259970776737643 1.443117565281 0.311319940620983 1.69221063135374 0.304843709771537 0.603808013021114 NA NA NA 0.111315304322553 99.4766901953356 a7006 CDH1_mut 167 OSU-03012 PDPK1 (PDK1) 4 44 2.77258872223978 NA 1.95047157412144 2.27502515971729 -0.324553585595857 0.646607010640574 1.21840308375947 0.272844154284599 0.501933292177473 0.266376201703647 0.603859571967038 NA NA NA 0.421142889699352 99.4766901953356 a7007 PIK3CA_mut 238 CAL-101 PI3Kdelta 17 32 2.99573227355399 2.32630161961136 4.8161359406982 4.66734174250936 0.148794198188841 1.03896466746622 0.900232228611011 0.15666865221417 0.143213915591291 0.165284238288624 0.604111128246172 NA NA NA 0.62137330385704 99.4766901953356 a7008 loss_cnaBRCA7_(FAS,PTEN) 329 QL-XI-92 DDR1 4 44 2.32630161961136 NA 4.01573311920211 4.27493527810089 -0.259202158898776 0.760731654203031 0.96290554479883 0.27254851077395 0.340727452928622 0.269187523427262 0.60425056311163 NA NA NA 0.559519986187962 99.4766901953356 a7009 loss_cnaBRCA18 1261 rTRAIL TR10A (DR4), TR10B (DR5) 15 32 -2.30258509299405 NA -0.256473414510294 -0.086292877529515 -0.170180536980779 1.02060478600203 1.05161298913178 0.16331088520311 0.166744796139375 0.161828104768163 0.604299953697006 NA NA NA 0.601826364311561 99.4766901953356 a7010 gain_cnaBRCA58_(CCND1) 1072 BMS-708163 g-secretase 8 38 1.6094379124341 NA 3.52331114945192 3.71813158353491 -0.194820434082985 0.73098026551521 0.996899483092094 0.203036006779262 0.266519416834969 0.195426356806514 0.604321300422377 NA NA NA 0.533756425004113 99.4766901953356 a7011 loss_cnaBRCA60 1149 TW 37 BCL2, BCL2L1 3 40 1.6094379124341 NA 0.222076257174789 -0.169718779769122 0.391795036943911 1.25630281376839 1.25334047345434 0.312564564471401 0.311863535327672 0.312600642237365 0.604375059474224 NA NA NA 0.648044895347411 99.4766901953356 a7012 loss_cnaBRCA28_(GPS2) 167 OSU-03012 PDPK1 (PDK1) 4 44 2.77258872223978 NA 2.54487946686455 2.22098807855883 0.323891388305718 1.22749553909896 1.18684065316691 0.272284168220285 0.263863597046935 0.27290216883072 0.604600257841085 NA NA NA 0.642393877973986 99.4766901953356 a7013 loss_cnaBRCA17 157 JNK-9L JNK 10 37 1.63315443905142 NA -0.0993242372555873 0.097781739739961 -0.197105976995548 1.12644380997231 1.04366785258053 0.18581932412284 0.174980744934266 0.188858913789663 0.604668326061661 NA NA NA 0.626152644961564 99.4766901953356 a7014 BRCA1_mut 290 KIN001-260 IKK 4 45 2.99573227355399 NA 5.30531198528247 5.02085244832083 0.284459536961641 0.503636239443691 1.07370792006695 0.271783835907173 0.564811494255954 0.264931953695475 0.60487587777373 NA NA NA 0.378137169213462 99.4766901953356 a7015 POLR2B_mut 299 OSI-027 MTORC1/2 3 45 2.99573227355399 NA 0.688489936007099 1.307668205472 -0.619178269464901 1.98671091015904 1.99442287484799 0.310506963473249 0.311659973425793 0.310454857529697 0.605048399133931 NA NA NA 0.647736133875308 99.4766901953356 a7016 POLR2B_mut 1066 AZD6482 PI3Kbeta 3 40 1.6094379124341 NA 2.38665879849403 1.93572730094095 0.450931497553082 1.95433160912168 1.41491655449637 0.311867820676162 0.230734382767181 0.318698297874951 0.605178417760557 NA NA NA 0.730375948887152 99.4766901953356 a7017 NF1_mut 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 38 -1.38629436111989 0.693147180559945 0.12015758128262 -0.346700563560052 0.466858144842672 1.73743695135934 1.7021692621515 0.273842848437404 0.268705085659316 0.274272456460984 0.605271719189168 NA NA NA 0.638078474594722 99.4766901953356 a7018 PIK3CA_mut 1259 BMN-673 PARP1 16 30 2.30258509299405 NA 3.14111077391415 3.3932325826739 -0.252121808759753 1.930214479713 1.33663880674849 0.161151411299658 0.13061854597487 0.188623738504992 0.605278965043922 NA NA NA 0.645449487190536 99.4766901953356 a7019 loss_cnaBRCA38 225 Genentech Cpd 10 AURKA, AURKB 4 45 2.32630161961136 NA 2.61403414228835 3.05397716285193 -0.439943020563576 1.65895515304549 1.61845252440847 0.271390843141626 0.265192835234837 0.271829425904458 0.605396636688001 NA NA NA 0.640737773594967 99.4766901953356 a7020 NF1_mut 1059 AZD8055 MTORC1/2 4 39 0.693147180559945 NA 0.3815570489243 0.104674188492865 0.276882860431435 1.45713367072493 0.969246416346595 0.273344343849599 0.190018847271359 0.28566818072446 0.605417554069088 NA NA NA 0.732861891924493 99.4766901953356 a7021 gain_cnaBRCA9_(KRAS) 302 PI-103 PI3Ka, PRKDC (DNAPK) 4 44 2.32630161961136 NA 1.59169773480622 1.0863181980046 0.505379536801612 2.62826291121038 1.79703720791155 0.271331669614675 0.192286523028578 0.281229311544943 0.605861080782162 NA NA NA 0.729627090820986 99.4766901953356 a7022 loss_cnaBRCA36_(FAT1,IRF2) 302 PI-103 PI3Ka, PRKDC (DNAPK) 9 39 2.32630161961136 NA 1.41919036278282 1.06133534324057 0.357855019542248 1.78776363851676 1.877962935023 0.192127649404842 0.200169089376461 0.190554889486072 0.605872162437699 NA NA NA 0.601346426964349 99.4766901953356 a7023 gain_cnaBRCA27_(CLTC,PPM1D) 219 AT-7519 CDK9 9 40 2.32630161961136 NA 1.95670384579673 1.60794225131945 0.348761594477278 1.92765177148975 1.79751695073841 0.191593070383499 0.180925621336547 0.194024092142223 0.605976383713075 NA NA NA 0.629097044422091 99.4766901953356 a7024 gain_cnaBRCA19 1022 AZD7762 CHEK1, CHEK2 4 41 0.693147180559945 NA 0.500575442959761 0.944182416609505 -0.443606973649744 1.08507115019653 1.66451563906073 0.272020676877463 0.408827544230071 0.266508144014836 0.606214976076807 NA NA NA 0.497368658078775 99.4766901953356 a7025 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 273 CUDC-101 HDAC, EGFR 9 40 1.63315443905142 NA 0.219625329421247 -0.0820601254557957 0.301685454877043 0.957348683396711 1.67465403828116 0.191450334214781 0.315125993391092 0.180147927858991 0.606244068707938 NA NA NA 0.475010410689288 99.4766901953356 a7026 loss_cnaBRCA28_(GPS2) 282 EKB-569 EGFR 4 43 0.916290731874155 2.99573227355399 1.05053722799027 1.62714003104402 -0.57660280305375 2.01584710640854 2.1335521791739 0.271226610410764 0.286034988080536 0.270254840112233 0.606402931023558 NA NA NA 0.617655367562659 99.4766901953356 a7027 CDH1_mut 223 ZSTK474 PI3K 4 45 1.63315443905142 2.32630161961136 0.550940738151213 0.944462158948649 -0.393521420797435 1.50428117976513 1.45079920508499 0.27059690218972 0.2616009733359 0.27124457982756 0.606449328293897 NA NA NA 0.644932227287256 99.4766901953356 a7028 gain_cnaBRCA13_(FGFR1,WHSC1L1) 167 OSU-03012 PDPK1 (PDK1) 10 38 2.77258872223978 NA 2.42153786333655 2.20230564975477 0.219232213581781 1.1922183246547 1.18892790504426 0.184294973365579 0.183885962032397 0.184394875964846 0.606565137132755 NA NA NA 0.612705617759416 99.4766901953356 a7029 gain_cnaBRCA63 1230 IOX2 EGLN1 6 41 -2.30258509299405 NA 0.379296309642392 0.230462673675168 0.148833635967223 0.651853487462297 0.657561046027749 0.226559587242501 0.228323754999979 0.226341929568837 0.606771816260975 NA NA NA 0.61891784563248 99.4766901953356 a7030 gain_cnaBRCA16 291 KIN001-266 MAP3K8 (COT) 16 33 2.99573227355399 NA 3.90463694655482 3.71754226952272 0.187094677032103 1.44858415777212 1.03914070475829 0.157848264437225 0.129156926111803 0.180047491331428 0.606781704639832 NA NA NA 0.648341935554748 99.4766901953356 a7031 loss_cnaBRCA60 294 MPS-1-IN-1 MPS1 3 46 2.99573227355399 NA 5.0977832993282 4.73426125101675 0.363522048311446 0.931477991372286 1.18748169110777 0.308665392682518 0.390263700998338 0.306128550051434 0.606888474862191 NA NA NA 0.575487193602947 99.4766901953356 a7032 loss_cnaBRCA36_(FAT1,IRF2) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 9 34 1.6094379124341 NA 2.31969861908943 2.63289389790035 -0.313195278810924 1.22190003153276 1.69280407957195 0.194318749652867 0.256318250862185 0.185015668730029 0.606985462010849 NA NA NA 0.539461326306643 99.4766901953356 a7033 MACF1_mut 1494 SN-38 TOP1 3 45 -2.99573227355399 NA -2.81410205828732 -3.33643427336601 0.522332215078683 0.913106844363858 1.71838328606093 0.308823326888695 0.572038440301673 0.303967234385776 0.607001442831384 NA NA NA 0.437549701640326 99.4766901953356 a7034 gain_cnaBRCA10_(MDM2,NUP107) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 3 40 1.6094379124341 NA 2.50923602131695 2.97865689063225 -0.469420869315299 1.91887554588264 1.48943530449901 0.310214514407596 0.244633306377031 0.315167008528238 0.607086693069328 NA NA NA 0.715729129578606 99.4766901953356 a7035 loss_cnaBRCA18 60 BI-2536 PLK1, PLK2, PLK3 5 7 -1.36257783450257 NA -1.20643588177059 -1.70601312725891 0.499577245488319 1.66164888352249 1.57059393940307 0.310752922142675 0.300651509739697 0.318081735167137 0.607202691960514 NA NA NA 0.612917587747788 99.4766901953356 a7036 gain_cnaBRCA27_(CLTC,PPM1D) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 10 37 2.99573227355399 NA 3.63935350939577 3.90396204917092 -0.26460853977515 1.2702331446738 1.47258015791852 0.184473822235738 0.208314938784802 0.179690415052972 0.607278932206397 NA NA NA 0.580348537393063 99.4766901953356 a7037 loss_cnaBRCA20 290 KIN001-260 IKK 3 46 2.99573227355399 NA 4.741208456572 5.06382571186633 -0.322617255294338 1.17369894192518 1.0406757530072 0.308228894325724 0.274872238331543 0.310007468091847 0.6073957010849 NA NA NA 0.68417554620037 99.4766901953356 a7038 loss_cnaBRCA20 262 VX-11e ERK 3 46 1.63315443905142 NA 4.16347916500535 3.75159451718592 0.411884647819423 0.679237634226679 1.35858055928241 0.308129876280634 0.606392559929868 0.303172782066731 0.607510790657092 NA NA NA 0.4152309892587 99.4766901953356 a7039 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 165 DMOG Prolyl-4-Hydroxylase 6 40 8.29404964010203 NA 7.26618147313793 7.61555044359208 -0.349368970454154 1.39522003813045 1.56044733961 0.226486021636612 0.250404209304719 0.223890266326751 0.607516586355185 NA NA NA 0.591062908587858 99.4766901953356 a7040 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 304 SB52334 ALK5 9 40 2.99573227355399 NA 4.50108417110282 4.25707345258223 0.244010718520583 1.23997001415575 1.28709589772455 0.190753029308128 0.196787596260318 0.189582391608867 0.607552566592053 NA NA NA 0.60586228172219 99.4766901953356 a7041 loss_cnaBRCA38 1129 PF-4708671 RPS6KB1 (p70S6KA) 3 40 2.30258509299405 NA 3.4773248866977 3.83384007609512 -0.356515189397422 0.431856504414132 1.17598529704981 0.309769888451992 0.825540858487427 0.303162964955269 0.607600363284492 NA NA NA 0.305950591936934 99.4766901953356 a7042 loss_cnaBRCA7_(FAS,PTEN) 310 YM201636 FYV1 4 45 1.63315443905142 NA 2.6676968785241 2.39217598204614 0.275520896477963 0.804524482374192 1.03480377331972 0.269680410719037 0.342464278607019 0.266254244120191 0.607665559771799 NA NA NA 0.557761840001788 99.4766901953356 a7043 loss_cnaBRCA36_(FAT1,IRF2) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 9 39 2.07944154167984 NA 3.03312277118111 3.25611437688592 -0.222991605704805 0.720570632861572 1.24010867548808 0.191163589748429 0.309465298105819 0.179816180720646 0.607676434809487 NA NA NA 0.482299495337833 99.4766901953356 a7044 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1030 KU-55933 ATM 16 26 2.30258509299405 NA 4.31663662908409 4.16424564794869 0.1523909811354 0.803475820199299 0.994130263116838 0.164348980374658 0.189664676029205 0.153290757548832 0.607839779922192 NA NA NA 0.589444145317465 99.4766901953356 a7045 gain_cnaBRCA9_(KRAS) 1016 Temsirolimus MTOR 4 40 -1.6094379124341 NA -1.37974452104265 -1.78806060292255 0.408316081879902 1.8366279318954 1.47765764019539 0.271101306006719 0.222318344825846 0.276326579833412 0.607889033269269 NA NA NA 0.692417932397647 99.4766901953356 a7046 loss_cnaBRCA38 1022 AZD7762 CHEK1, CHEK2 3 42 0.693147180559945 NA 0.434604862261465 0.938332530143913 -0.503727667882448 1.40454626071588 1.64107217897237 0.308877753043286 0.358640852189306 0.306950342792284 0.607908278847801 NA NA NA 0.604197871511532 99.4766901953356 a7047 gain_cnaBRCA16 1529 MLN4924 NEDD8-activating enzyme 13 24 0 NA 0.566919755917002 0.262125343750791 0.304794412166212 1.94426617159645 1.57361511702728 0.178266180035754 0.156765784756695 0.193690572026277 0.607951563618119 NA NA NA 0.632356889833749 99.4766901953356 a7048 gain_cnaBRCA62 133 Doxorubicin DNA intercalating 9 39 0.0237165266173161 NA -0.74466596284705 -1.096640142154 0.351974179306945 2.10912971958046 1.78281691473428 0.190904331017617 0.16688123828484 0.197425869363263 0.608162068963395 NA NA NA 0.651962154139802 99.4766901953356 a7049 gain_cnaBRCA31 194 AUY922 HSP90 15 32 -1.36257783450257 NA -2.20282198315138 -2.48324321152923 0.28042122837785 1.9959131529576 1.60461148661303 0.161548947199605 0.140497710515267 0.174759579323314 0.608194506434333 NA NA NA 0.638106339894952 99.4766901953356 a7050 loss_cnaBRCA42 224 AS605240 PI3Kgamma 3 46 2.99573227355399 2.32630161961136 3.72866081420734 3.24036083204885 0.488299982158485 0.366287621466313 1.62099372507386 0.307507579280337 1.33310533455577 0.301234961372991 0.608234321908295 NA NA NA 0.158022042315993 99.4766901953356 a7051 BRCA2_mut 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 3 23 2.30258509299405 NA 4.40352376122972 4.72260933749595 -0.319085576266236 0.809259180204227 1.01748070874338 0.318517564183464 0.39429342795433 0.313603563708168 0.608592734429633 NA NA NA 0.579522874900561 99.4766901953356 a7052 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 235 QL-XII-47 BTK, BMX 6 43 2.32630161961136 NA 2.00592564233009 1.66651455330767 0.339411089022422 1.52524753725896 1.50938212344771 0.224615223313242 0.22252852781679 0.224867569152829 0.608684002051473 NA NA NA 0.626203127797619 99.4766901953356 a7053 loss_cnaBRCA34 166 FTI-277 Farnesyl transferase (FNTA) 5 42 0.0237165266173161 NA 2.06596740822821 2.26562845278354 -0.199661044555331 0.655613156046957 0.833181596062151 0.243798802391593 0.304540936547391 0.239636887683291 0.608839274219338 NA NA NA 0.557109991097222 99.4766901953356 a7054 gain_cnaBRCA15 204 Tipifarnib Farnesyl-transferase (FNTA) 22 26 2.77258872223978 NA 1.74295846511922 1.51591488797849 0.227043577140724 1.80200216331499 1.23691872402816 0.14925688913782 0.125995174569076 0.183555776729883 0.608850841656926 NA NA NA 0.620308852333687 99.4766901953356 a7055 loss_cnaBRCA34 1004 Vinblastine Microtubules 5 40 -2.30258509299405 NA -3.17531926227882 -3.49059049232171 0.315271230042888 1.60748976335399 1.25260303820242 0.244445236685464 0.19612643092985 0.251692851148857 0.608957772423834 NA NA NA 0.69136208792787 99.4766901953356 a7056 gain_cnaBRCA62 1072 BMS-708163 g-secretase 8 38 1.6094379124341 NA 3.84310827070257 3.65080587379793 0.192302396904642 1.46107772595739 0.831385163231223 0.200395851220481 0.131616815100397 0.23130361883925 0.609016159154052 NA NA NA 0.728049086155601 99.4766901953356 a7057 loss_cnaBRCA22_(SYNCRIP,ZNF292) 201 Epothilone B Microtubules 18 30 -3.44201937618241 NA -4.06177279785958 -4.34014900092116 0.278376203061576 1.92643710848543 1.74309572721403 0.153543374383578 0.144503135781285 0.159702188878921 0.609018941114851 NA NA NA 0.618958510650175 99.4766901953356 a7058 gain_cnaBRCA48 164 JQ12 HDAC 5 42 1.63315443905142 NA 1.93701540837552 1.5351293335614 0.401886074814114 2.15730662319059 1.5910910249163 0.243668989501908 0.186290660073039 0.252585218897363 0.609029452301536 NA NA NA 0.704769169137646 99.4766901953356 a7059 loss_cnaBRCA20 170 Shikonin unknown 3 44 2.77258872223978 NA 0.346500916638564 -0.0197710549025742 0.366271971541138 0.784354938969758 1.20798438818413 0.307183213749598 0.466972225638348 0.303209193035786 0.609214756546032 NA NA NA 0.513064783786865 99.4766901953356 a7060 loss_cnaBRCA17 63 BMS-509744 ITK 3 9 2.32630161961136 NA 3.88788621850768 3.4989250641422 0.388961154365478 0.165839015608234 1.23340284150711 0.351784805165976 2.34541403263229 0.315356136110568 0.60923133764235 NA NA NA 0.381434898485089 99.4766901953356 a7061 gain_cnaBRCA16 256 JW-7-24-1 LCK 16 32 2.32630161961136 NA 1.71473484689046 1.89898626951428 -0.184251422623825 1.29920395208014 1.10093251432412 0.157575985638267 0.141818705468701 0.167359415973776 0.609267932465482 NA NA NA 0.630601667094039 99.4766901953356 a7062 PTEN_mut 291 KIN001-266 MAP3K8 (COT) 9 40 2.99573227355399 NA 3.5949675818354 3.81995944506521 -0.224991863229809 1.36576424894899 1.14480714521959 0.189813821604313 0.164736969358327 0.196532546262762 0.609317049670299 NA NA NA 0.655270692621938 99.4766901953356 a7063 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1009 ATRA Retinoic acid and retinoid X receptor agonist 6 39 2.30258509299405 NA 4.3335344862878 4.07096108470859 0.262573401579216 0.916193775976813 1.19187178826508 0.225737934089842 0.28659155788225 0.220303395184329 0.60935556232649 NA NA NA 0.549463167778727 99.4766901953356 a7064 loss_cnaBRCA22_(SYNCRIP,ZNF292) 53 CGP-60474 CDK1,CDK2,CDK5,CDK7,CDK9 3 9 -1.36257783450257 NA -2.10587998115209 -1.5649962956566 -0.540883685495493 0.682220590826006 1.68546539435351 0.35165939448793 0.792828144985498 0.320910584879114 0.609357215413717 NA NA NA 0.45067293775307 99.4766901953356 a7065 gain_cnaBRCA27_(CLTC,PPM1D) 208 SB-715992 KIF11 9 40 -2.05572501506252 NA -0.974066047058463 -1.29971176178147 0.325645714723004 1.94229565824879 1.66566980536085 0.189780482160408 0.167660218638707 0.195504363274722 0.609379727468615 NA NA NA 0.65053163010606 99.4766901953356 a7066 gain_cnaBRCA8_(CHD4,WNK1) 265 Tubastatin A HDAC6 4 45 2.99573227355399 NA 4.94798392765082 4.66898398804269 0.278999939608126 1.12552093843878 1.03370145758081 0.268319597417948 0.247885161510305 0.269903788528146 0.609473498025734 NA NA NA 0.661104428054791 99.4766901953356 a7067 gain_cnaBRCA19 1175 AG-014699 PARP1, PARP2 3 40 1.6094379124341 NA 3.56580211371545 3.88375328866579 -0.317951174950339 0.948817923568605 1.03593842496485 0.308134230132876 0.335102412225193 0.306920920479543 0.609491744742037 NA NA NA 0.626183759144565 99.4766901953356 a7068 loss_cnaBRCA28_(GPS2) 304 SB52334 ALK5 4 45 2.99573227355399 NA 3.98686955761248 4.32989372028366 -0.343024162671183 0.540749285294428 1.31457043408867 0.26814676227085 0.634349729162217 0.260940116844317 0.609703298503229 NA NA NA 0.339196517429637 99.4766901953356 a7069 gain_cnaBRCA58_(CCND1) 1008 Methotrexate Dihydrofolate reductase (DHFR) 9 36 -1.6094379124341 NA 0.850482750338699 0.640691905475986 0.209790844862712 0.634984738210751 1.17522173825577 0.191575536204562 0.330387223878573 0.17851171232935 0.609848071485134 NA NA NA 0.474091561169752 99.4766901953356 a7070 loss_cnaBRCA36_(FAT1,IRF2) 173 FH535 unknown 9 39 3.46573590279973 NA 1.77152824750987 1.52718341389436 0.244344833615512 1.00306813161005 1.33816636059831 0.189977864675748 0.243597444595621 0.182596753894085 0.609898950582593 NA NA NA 0.547367948746521 99.4766901953356 a7071 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 110 Roscovitine CDKs 4 9 2.77258872223978 NA 4.30796488791835 3.97871689041304 0.32924799750531 1.00391397831093 1.05774161347569 0.315572112871702 0.327964352144259 0.311274505333506 0.609904675807218 NA NA NA 0.610351165255825 99.4766901953356 a7072 gain_cnaBRCA9_(KRAS) 1494 SN-38 TOP1 4 44 -2.99573227355399 NA -2.88783552122796 -3.34160241798683 0.453766896758867 1.11268844886419 1.72458734456841 0.268272224169792 0.407811276572579 0.263116216286758 0.609919068879224 NA NA NA 0.49713687748568 99.4766901953356 a7073 gain_cnaBRCA48 345 KIN001-270 CDK9 5 44 2.99573227355399 NA 5.25852311119927 5.09043515601499 0.168087955184281 0.386602783742074 0.715371776551058 0.242381098672105 0.434782061208391 0.234965874659837 0.609948486647738 NA NA NA 0.434527572905648 99.4766901953356 a7074 BRCA1_mut 1047 Nutlin-3a MDM2 4 39 2.07944154167984 1.38629436111989 3.95959933145313 4.23231331027452 -0.272713978821386 0.947476504410451 1.01525434553245 0.269893814682912 0.287831917258019 0.268616411268214 0.609963880218886 NA NA NA 0.616895563079031 99.4766901953356 a7075 ARID1A_mut 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 5 41 0 NA 1.10219155194983 0.598461925113098 0.503729626836732 1.23502425446324 2.13536238531711 0.243375762486815 0.407870230091684 0.235898894866936 0.609977990007522 NA NA NA 0.459353806117409 99.4766901953356 a7076 gain_cnaBRCA10_(MDM2,NUP107) 1262 UNC1215 LMBL3 3 43 0 NA 2.92870389759777 2.74557726883977 0.183126628757992 0.334545870877604 0.606587068274582 0.306787260941839 0.547388698230236 0.301896691070072 0.609996102533534 NA NA NA 0.455064516316895 99.4766901953356 a7077 PIK3CA_mut 201 Epothilone B Microtubules 17 31 -3.44201937618241 NA -4.41721441771609 -4.13624952541722 -0.280964892298876 2.22988704745099 1.54541869231866 0.154968603684323 0.125999607298517 0.181805030374863 0.610069226846415 NA NA NA 0.648000193999776 99.4766901953356 a7078 gain_cnaBRCA8_(CHD4,WNK1) 194 AUY922 HSP90 3 44 -1.36257783450257 NA -2.89168772925032 -2.35979657564671 -0.531891153603615 1.00115367861996 1.76261837984354 0.306409575971424 0.531278229269256 0.301761946707277 0.610113833263161 NA NA NA 0.465826824804722 99.4766901953356 a7079 PIK3CA_mut 310 YM201636 FYV1 17 32 1.63315443905142 NA 2.31193935597519 2.46924180170607 -0.157302445730886 1.15752064962813 0.943984236682206 0.153961440077148 0.135896016871424 0.166636729320558 0.610357522727352 NA NA NA 0.63386214024518 99.4766901953356 a7080 gain_cnaBRCA62 1373 Dabrafenib BRAF 8 38 2.30258509299405 NA 3.94363940355041 4.27163117953176 -0.327991775981347 3.37812903457746 1.02556915122448 0.199610616440301 0.0970927316938242 0.319814393392919 0.610415736172425 NA NA NA 0.793186369764567 99.4766901953356 a7081 NF1_mut 274 PXD101, Belinostat HDAC 4 44 2.99573227355399 NA 0.302482956862544 0.70505065406617 -0.402567697203626 0.979042892430076 1.53265722529118 0.267881705535871 0.411184944312721 0.262659967643545 0.610437941482562 NA NA NA 0.49426619695963 99.4766901953356 a7082 NF1_mut 253 XMD14-99 EPHB3, CAMK1 4 44 2.32630161961136 NA 4.74239870867705 4.95043848854533 -0.208039779868281 0.419400974157889 0.795713359390598 0.26783414703148 0.49604028766505 0.261450656085013 0.610501145128312 NA NA NA 0.426764195501558 99.4766901953356 a7083 loss_cnaBRCA7_(FAS,PTEN) 1262 UNC1215 LMBL3 4 42 0 NA 2.90379674536807 2.74358922074836 0.160207524619703 0.210242082781655 0.615755608699285 0.268388860733128 0.762014542949926 0.2601803740905 0.610580702586103 NA NA NA 0.286106816421551 99.4766901953356 a7084 MACF1_mut 1024 CEP-701 FLT3, JAK2, NTRK1, RET 3 42 0.693147180559945 NA 0.212699173419731 0.655059618708275 -0.442360445288544 1.95183841251819 1.41346030534248 0.306564122900878 0.226637841765716 0.312962764936905 0.610590879478337 NA NA NA 0.73472642875204 99.4766901953356 a7085 gain_cnaBRCA58_(CCND1) 274 PXD101, Belinostat HDAC 10 38 2.99573227355399 NA 0.454779158765097 0.728536026808175 -0.273756868043079 1.58696988470377 1.48158863739662 0.182165957655299 0.172502875247806 0.184772521287766 0.610716867179726 NA NA NA 0.630671135355398 99.4766901953356 a7086 loss_cnaBRCA29_(MAP2K4) 219 AT-7519 CDK9 7 42 2.32630161961136 NA 1.34555304471378 1.72640841314171 -0.380855368427937 1.71499162758092 1.83538731816847 0.209208192482021 0.222074185263022 0.207506810501444 0.610733761791401 NA NA NA 0.604162662635113 99.4766901953356 a7087 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1268 XAV 939 TNKS1 (tankyrase-1) 18 29 1.6094379124341 NA 3.57189924046444 3.71702137595582 -0.145122135491375 1.08454976096125 0.847007168584453 0.153763880350521 0.133808646421858 0.171335191570938 0.61085122959612 NA NA NA 0.632276756093413 99.4766901953356 a7088 loss_cnaBRCA60 219 AT-7519 CDK9 3 46 2.32630161961136 NA 1.15044922036185 1.70601471747528 -0.555565497113431 1.52159440703628 1.83261941680906 0.305177440374103 0.365120622515657 0.303153776511206 0.610947037635292 NA NA NA 0.597889867613311 99.4766901953356 a7089 gain_cnaBRCA47_(EGFR) 1268 XAV 939 TNKS1 (tankyrase-1) 7 40 1.6094379124341 NA 3.82996307362238 3.63195161789305 0.198011455729329 0.352380633803794 1.00434059193941 0.209801814251121 0.561924909413672 0.19715568335933 0.611097942619776 NA NA NA 0.347911603582373 99.4766901953356 a7090 loss_cnaBRCA20 204 Tipifarnib Farnesyl-transferase (FNTA) 3 45 2.77258872223978 NA 2.0553736505458 1.59095005263169 0.464423597914111 0.368577560139457 1.55341713316388 0.305297895018009 1.26004306322498 0.298969019974827 0.611100387986341 NA NA NA 0.173974304276571 99.4766901953356 a7091 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 150 Bicalutamide ANDR (androgen receptor) 9 39 0.0237165266173161 NA 2.85892317608009 2.74035648976946 0.118566686310625 0.202677466613354 0.682889745106491 0.189281947502242 0.585001817379205 0.173624933102686 0.611205107976524 NA NA NA 0.361463355800119 99.4766901953356 a7092 loss_cnaBRCA24 167 OSU-03012 PDPK1 (PDK1) 3 45 2.77258872223978 NA 1.90758726260124 2.27067181191651 -0.363084549315268 0.538231903433725 1.21097379476114 0.305199946925712 0.674587565320672 0.299828576709114 0.611214450909272 NA NA NA 0.376012704773785 99.4766901953356 a7093 PTEN_mut 258 STF-62247 stimulates autophagy 9 40 2.32630161961136 NA 4.48210480007089 4.66430897907714 -0.182204179006246 0.751243154682394 1.00413352444027 0.188660872938658 0.242536890846316 0.181454133908945 0.611486296684215 NA NA NA 0.547956319840292 99.4766901953356 a7094 MLL3_mut 1010 Gefitinib EGFR 3 42 -0.693147180559945 NA 1.69861965093394 1.37856054066046 0.320059110273475 0.92570141101858 1.05250660828073 0.305706405789526 0.345747674643062 0.304092257241302 0.611586762272364 NA NA NA 0.616109437735405 99.4766901953356 a7095 ARID1A_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 41 1.38629436111989 NA 2.53724414291098 2.8978001099517 -0.360555967040723 1.03371222793398 1.526695172282 0.242204928982614 0.348797235146717 0.236167621138009 0.611693125176927 NA NA NA 0.512686991505493 99.4766901953356 a7096 loss_cnaBRCA28_(GPS2) 1026 17-AAG HSP90 3 40 0 NA -0.384626829720638 -0.934575136763742 0.549948307043104 1.07964165142458 1.82506538141484 0.306225036977 0.509380409988306 0.301330742801537 0.611702852635178 NA NA NA 0.482927851642929 99.4766901953356 a7097 gain_cnaBRCA14_(RAD21) 1018 ABT-888 PARP1, PARP2 20 25 1.6094379124341 NA 4.45998457680611 4.35754948419459 0.102435092611526 0.779160469103707 0.564141788276727 0.153404958732473 0.131468544251687 0.181576856634629 0.611721985427593 NA NA NA 0.624870080605901 99.4766901953356 a7098 loss_cnaBRCA17 253 XMD14-99 EPHB3, CAMK1 10 38 2.32630161961136 NA 5.04472422885368 4.90372752742542 0.140996701428265 0.480292324149217 0.833078721971991 0.181517395735658 0.293564344751969 0.169247752594749 0.611984190932874 NA NA NA 0.494351362223097 99.4766901953356 a7099 POLR2B_mut 287 KIN001-244 PDPK1 (PDK1) 3 46 2.99573227355399 NA 3.74866045514568 3.46046118881663 0.28819926632905 1.17644268479298 0.935650529889527 0.304282135091309 0.244975186683034 0.308020203187484 0.611990810197354 NA NA NA 0.71511847843619 99.4766901953356 a7100 gain_cnaBRCA8_(CHD4,WNK1) 152 CP466722 ATM 4 45 2.77258872223978 NA 2.46948089469533 2.75331161543118 -0.283830720735852 0.886611668562811 1.0774283377396 0.266190463419296 0.320129692400664 0.263433502530032 0.612307146462164 NA NA NA 0.580968399352521 99.4766901953356 a7101 loss_cnaBRCA7_(FAS,PTEN) 1194 SB-505124 TGFR1 (ALK5) 4 43 2.30258509299405 NA 4.16385430589602 4.40994279002169 -0.24608848412567 1.16484621060054 0.902725823539789 0.266756652570687 0.211262638695281 0.272606009165332 0.612331371671551 NA NA NA 0.705884094029457 99.4766901953356 a7102 loss_cnaBRCA57 153 Midostaurin KIT 5 42 -0.669430653942629 NA 0.927596386371421 0.574634978618877 0.352961407752543 1.50566567549547 1.45834598395546 0.241322294179589 0.234422165223627 0.24202858007344 0.612472100770024 NA NA NA 0.64042168569366 99.4766901953356 a7103 BRCA1_mut 1375 Temozolomide DNA akylating agent 4 42 3.40119738166216 NA 6.0711083878559 5.88384189232708 0.187266495528825 0.283868441763991 0.722659345566313 0.266945715661145 0.659694661249169 0.259135229728571 0.612495486191635 NA NA NA 0.331247259112041 99.4766901953356 a7104 loss_cnaBRCA7_(FAS,PTEN) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 41 2.30258509299405 NA 3.49537386732062 3.14579313537934 0.34958073194128 0.794359596768004 1.33956143617719 0.267076905443612 0.44007869151907 0.260966554052874 0.612755799203506 NA NA NA 0.472275319878407 99.4766901953356 a7105 gain_cnaBRCA47_(EGFR) 202 GSK-1904529A IGF1R 7 41 0.0237165266173161 NA 2.04072157278162 2.21510539965502 -0.174383826873401 0.917157962608053 0.824089512010747 0.208389669026499 0.190134997440919 0.211607870664329 0.612794823117681 NA NA NA 0.650212078311868 99.4766901953356 a7106 loss_cnaBRCA38 302 PI-103 PI3Ka, PRKDC (DNAPK) 4 44 2.32630161961136 NA 0.674121159711741 1.16973425028592 -0.495613090574179 1.87033235209707 1.86227200298358 0.266058313037921 0.264986642624496 0.266133566836718 0.61286331191162 NA NA NA 0.641524161240767 99.4766901953356 a7107 BRCA1_mut 300 CX-5461 RNA Pol I 4 45 2.32630161961136 NA 4.33115443935645 3.87513959134526 0.456014848011191 0.942413639530519 1.75633300954648 0.265749978439462 0.483879719990432 0.259640310540507 0.612894134592353 NA NA NA 0.435430115733008 99.4766901953356 a7108 loss_cnaBRCA38 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 3 40 0.693147180559945 NA 3.18114658883836 2.88796410136686 0.293182487471503 0.586605000119051 0.976220909039104 0.305116359505161 0.499795411583606 0.300323917216732 0.612988541234347 NA NA NA 0.489971590069469 99.4766901953356 a7109 gain_cnaBRCA58_(CCND1) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 8 35 1.6094379124341 NA 2.3053948522697 2.62721489377883 -0.321820041509131 1.52110561811533 1.630012230674 0.199647731537423 0.211569819791915 0.197434126844594 0.61316190306139 NA NA NA 0.604912653794847 99.4766901953356 a7110 PIK3CA_mut 156 AZD6482 PI3Kbeta 16 31 1.63315443905142 NA 1.90147073326528 2.13167835352627 -0.230207620260994 1.69317630081291 1.34285196802224 0.156716894992541 0.135961990579758 0.171431867207258 0.613165746928637 NA NA NA 0.640648607206702 99.4766901953356 a7111 BRCA1_mut 1264 SGC0946 Q8TEK3 (DOT1L) 4 42 -0.693147180559945 NA 2.09907617052608 1.93658390073016 0.162492269795914 0.411161023769357 0.622032022991003 0.266391854821086 0.395203485744468 0.26122814226602 0.613231084377476 NA NA NA 0.509785758233176 99.4766901953356 a7112 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 176 IPA-3 PAK1, PAK2, PAK3 6 41 3.46573590279973 NA 4.79096174720737 4.45379716260799 0.337164584599376 1.36545072936029 1.53465949848776 0.222288099646269 0.246925485738571 0.219699930135392 0.613551020547478 NA NA NA 0.595773416213933 99.4766901953356 a7113 ARID1A_mut 192 LFM-A13 BTK 5 43 2.77258872223978 NA 4.97642243270505 4.77442915816398 0.201993274541072 0.342800706061856 0.873505367884926 0.240250155533866 0.589244044627561 0.231244457066326 0.613556294129159 NA NA NA 0.340087892124117 99.4766901953356 a7114 MLL3_mut 1230 IOX2 EGLN1 3 44 -2.30258509299405 NA 0.436091697177348 0.23673800879555 0.199353688381798 0.821990069925819 0.648307577991437 0.303429122382928 0.242525665060392 0.30749862434036 0.613583220647811 NA NA NA 0.717819884706138 99.4766901953356 a7115 loss_cnaBRCA7_(FAS,PTEN) 156 AZD6482 PI3Kbeta 4 43 1.63315443905142 NA 1.69609513218743 2.0865390735537 -0.390443941366269 1.72839250624329 1.44864134223831 0.265798005945927 0.225900042933483 0.269524229346506 0.613606253400928 NA NA NA 0.687898116493493 99.4766901953356 a7116 loss_cnaBRCA29_(MAP2K4) 333 T0901317 LXR 7 41 2.32630161961136 NA 4.87177745687587 4.71215843149499 0.159619025380882 0.702342073561516 0.777511380442769 0.207803728081956 0.227266785501641 0.205294776894435 0.613791302768022 NA NA NA 0.598232023859084 99.4766901953356 a7117 gain_cnaBRCA47_(EGFR) 179 5-Fluorouracil DNA antimetabolite 7 42 3.46573590279973 NA 3.75244782611044 4.08964816504454 -0.337200338934102 1.95897821529825 1.57113678314011 0.20740473223905 0.172130724221844 0.21462188560067 0.613804440604819 NA NA NA 0.677584463531056 99.4766901953356 a7118 gain_cnaBRCA63 345 KIN001-270 CDK9 7 42 2.99573227355399 NA 5.2308556312065 5.08704221433835 0.143813416868152 1.15829642841898 0.595844216928518 0.207364809751533 0.124159423563493 0.24136076642564 0.613872494452323 NA NA NA 0.75787522079358 99.4766901953356 a7119 gain_cnaBRCA8_(CHD4,WNK1) 1143 HG-5-88-01 EGFR, ADCK4 3 23 2.30258509299405 NA 4.26008641793886 4.5698149555323 -0.309728537593433 0.888744941172844 0.995692954263968 0.31373708213122 0.348501041462689 0.311068323088004 0.613952733599716 NA NA NA 0.618783202215818 99.4766901953356 a7120 loss_cnaBRCA29_(MAP2K4) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 6 39 0.693147180559945 NA 0.904243745417869 0.582695872653834 0.321547872764034 2.1866452510068 1.31424581627848 0.222825956960344 0.147050772234766 0.244663417437809 0.613965125519234 NA NA NA 0.738773822312913 99.4766901953356 a7121 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 305 TPCA-1 IKK 9 40 2.99573227355399 NA 3.96615790874579 4.22606426846393 -0.259906359718137 1.10389721486051 1.4387110003372 0.187328125426392 0.235444347733932 0.180652236381887 0.613998220931666 NA NA NA 0.557042442763838 99.4766901953356 a7122 POLR2B_mut 1230 IOX2 EGLN1 3 44 -2.30258509299405 NA 0.0632125639699712 0.26216158605969 -0.198949022089718 1.00426832892045 0.636262616657563 0.302809665892543 0.198103451398871 0.312683814640634 0.614305424719685 NA NA NA 0.765696005037221 99.4766901953356 a7123 gain_cnaBRCA19 221 TAK-715 p38a 4 45 2.99573227355399 2.32630161961136 4.23631867844985 4.50400462815746 -0.267685949707617 1.24301923209994 0.993585273311642 0.264682773654508 0.215351414358562 0.269414167961058 0.614317349088235 NA NA NA 0.700675689403297 99.4766901953356 a7124 gain_cnaBRCA62 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 8 37 2.30258509299405 NA 1.18510315759866 1.40429068727289 -0.219187529674225 1.81917373140593 0.907013357176817 0.197836854827472 0.120487409140867 0.241658546635378 0.614469812955332 NA NA NA 0.74868018239028 99.4766901953356 a7125 loss_cnaBRCA42 207 AS601245 JNK 3 45 2.07944154167984 NA 2.63174313156308 2.24183121858966 0.38991191297342 1.57517298040762 1.27509506676154 0.302352291409164 0.247535932766267 0.30579046467783 0.614534864791279 NA NA NA 0.712527126011463 99.4766901953356 a7126 loss_cnaBRCA57 228 KIN001-102 AKT1 5 44 2.32630161961136 NA 2.24735208249882 1.90919808614844 0.338153996350376 0.777326743427129 1.45846647682257 0.239259549865078 0.43502169352813 0.231855858001675 0.614546051663748 NA NA NA 0.4356550423729 99.4766901953356 a7127 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 7 38 2.30258509299405 NA 1.17015354572729 1.40127647025776 -0.231122924530479 0.809649818322442 1.1490189646037 0.208609132411038 0.285460354958586 0.20114805033718 0.614615203121045 NA NA NA 0.532096616322668 99.4766901953356 a7128 CDH1_mut 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 4 44 2.77258872223978 NA -0.779776002545238 -0.405322765083286 -0.374453237461952 1.21823562400493 1.42729406567963 0.264705735515898 0.30737340961262 0.262351849185086 0.614665267196503 NA NA NA 0.594845575848641 99.4766901953356 a7129 loss_cnaBRCA36_(FAT1,IRF2) 1022 AZD7762 CHEK1, CHEK2 8 37 0.693147180559945 NA 0.639612209532597 0.962077923691027 -0.32246571415843 1.25619983970268 1.69430057455493 0.19770792296573 0.256699375343617 0.190323794373461 0.614699860730721 NA NA NA 0.548954274356722 99.4766901953356 a7130 gain_cnaBRCA58_(CCND1) 1058 GDC0941 PI3K (class 1) 8 35 1.38629436111989 0.693147180559945 1.12060829285875 1.39752126135954 -0.276912968500794 1.10907988755774 1.44567799208478 0.198649788968504 0.249678108499988 0.191545399471333 0.614931914106791 NA NA NA 0.55917959206695 99.4766901953356 a7131 gain_cnaBRCA48 298 OSI-930 KIT, VEGFR, PDGFR 5 43 2.32630161961136 NA 4.10155197957094 3.89148535654354 0.210066623027401 1.00308541207517 0.865207684149199 0.23924031974271 0.209420474566387 0.242793293305029 0.615043832141725 NA NA NA 0.673128999830653 99.4766901953356 a7132 gain_cnaBRCA63 333 T0901317 LXR 7 41 2.32630161961136 NA 4.87129487449707 4.71224082360845 0.159054050888622 0.855958431930327 0.754084737901048 0.207064096508872 0.18581983067791 0.210923312585984 0.61505020883456 NA NA NA 0.656909556987018 99.4766901953356 a7133 loss_cnaBRCA24 194 AUY922 HSP90 3 44 -1.36257783450257 NA -2.88480474497797 -2.36026587002892 -0.524538874949049 0.71444468852824 1.76923963369426 0.30214980377752 0.734191020482779 0.296477009083154 0.615075161855649 NA NA NA 0.3458915961061 99.4766901953356 a7134 gain_cnaBRCA13_(FGFR1,WHSC1L1) 330 XMD13-2 RIPK 11 37 2.32630161961136 NA 3.88484603729948 3.67231657614464 0.212529461154846 1.21607420824411 1.22413374378641 0.173864415919681 0.174766851984894 0.173616210020863 0.615080929664542 NA NA NA 0.618081273856361 99.4766901953356 a7135 PIK3CA_mut 1018 ABT-888 PARP1, PARP2 16 29 1.6094379124341 NA 4.47095101846353 4.36562801191622 0.105323006547308 0.763649162617739 0.610259893042174 0.157720766105554 0.137920673135118 0.172587135002872 0.615123760314279 NA NA NA 0.63921636281192 99.4766901953356 a7136 NF1_mut 277 ABT-869 VEGFR and PDGFR family 4 44 0.0237165266173161 NA 2.57532338926055 2.70160141689418 -0.126278027633622 0.090818060366046 0.493515876244545 0.26433758443127 1.39045061218719 0.255874296475619 0.615156148891453 NA NA NA 0.158878082574368 99.4766901953356 a7137 gain_cnaBRCA61_(NOTCH2) 310 YM201636 FYV1 3 46 1.63315443905142 NA 2.70385046075653 2.39580772443267 0.308042736323852 0.202711505813304 1.04336253189531 0.301477158995503 1.51961150447749 0.295240366514101 0.615266191636956 NA NA NA 0.134779787902381 99.4766901953356 a7138 CDH1_mut 155 AP-24534 ABL 4 43 -0.669430653942629 NA 1.7213452670152 1.41968669057899 0.30165857643621 0.5958284686999 1.16953308604277 0.264542782050306 0.506284261801774 0.257930775996174 0.615277373493103 NA NA NA 0.421346075794114 99.4766901953356 a7139 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 326 GSK690693 AKT 9 39 2.32630161961136 NA 3.23431549409359 2.8715619635284 0.36275353056519 1.53406704595448 2.01391963031993 0.187081235874875 0.236465238935818 0.180123141511641 0.615343993642236 NA NA NA 0.557364291991629 99.4766901953356 a7140 loss_cnaBRCA34 230 GSK429286A ROCK2 5 44 2.99573227355399 2.32630161961136 5.21234757968448 5.42745313218946 -0.215105552504978 0.40737275488357 0.933998619442711 0.238677227955428 0.528031268479054 0.230306071151717 0.615405463466307 NA NA NA 0.372468274883352 99.4766901953356 a7141 gain_cnaBRCA12_(TERT) 1017 Olaparib PARP1, PARP2 10 35 1.6094379124341 NA 4.20026575255035 4.03805019646563 0.162215556084717 0.709393066793539 0.936785494125234 0.181451071734597 0.228668087803469 0.173161900031547 0.61541123481215 NA NA NA 0.561655778297202 99.4766901953356 a7142 NF1_mut 329 QL-XI-92 DDR1 4 44 2.32630161961136 NA 4.02306100937149 4.27426910626731 -0.251208096895819 0.712039210926258 0.965680193455651 0.264095354392908 0.352800931523188 0.260135911037877 0.615479228316449 NA NA NA 0.548670968916455 99.4766901953356 a7143 gain_cnaBRCA12_(TERT) 266 Zibotentan, ZD4054 Endothelin A Receptor 9 40 2.99573227355399 NA 5.66671829151948 5.75898663042428 -0.0922683389047956 0.569862207049668 0.477908209820377 0.186487968143994 0.161913420057269 0.193067072313897 0.615584133986097 NA NA NA 0.660773578676926 99.4766901953356 a7144 loss_cnaBRCA17 1010 Gefitinib EGFR 8 37 -0.693147180559945 NA 1.23013049102919 1.43660426303535 -0.20647377200616 0.982590173722897 1.05909348784284 0.197201278399087 0.210132135988964 0.194953301456612 0.615604225493968 NA NA NA 0.605911536216643 99.4766901953356 a7145 gain_cnaBRCA8_(CHD4,WNK1) 1006 Cytarabine DNA synthesis 3 42 0.693147180559945 NA 1.64176504221546 1.17758814854958 0.464176893665876 1.27851930417339 1.54773730823857 0.302146953088159 0.363058181562603 0.299906767895995 0.615727523213896 NA NA NA 0.600547414291121 99.4766901953356 a7146 loss_cnaBRCA33 41 S-Trityl-L-cysteine KIF11 4 8 1.63315443905142 NA 1.57755107609039 1.04744323336554 0.530107842724855 1.56488084698322 1.71490725133255 0.317180283011673 0.338752847379273 0.309117500268857 0.615755579415204 NA NA NA 0.609696173915358 99.4766901953356 a7147 loss_cnaBRCA29_(MAP2K4) 1378 Bleomycin (50 uM) DNA damage 7 41 3.91202300542815 NA 4.14715515427803 3.75561852078645 0.391536633491576 1.51268450575464 1.94595102366821 0.20660866366874 0.25883562104462 0.201205800520873 0.615825971395553 NA NA NA 0.55918558747676 99.4766901953356 a7148 MLL3_mut 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 3 40 1.6094379124341 NA 3.27186761883849 2.8376658052816 0.434201813556896 1.62657504399078 1.42438903482998 0.302598032654777 0.266942380040203 0.304833723750705 0.61591353102083 NA NA NA 0.692860918467858 99.4766901953356 a7149 loss_cnaBRCA29_(MAP2K4) 255 CP724714 ERBB2 7 41 2.32630161961136 NA 4.09873125242052 3.75255107618528 0.34618017623524 1.05911785970527 1.75053748876317 0.20647732733217 0.326857084943854 0.197756505334731 0.616049765883148 NA NA NA 0.488272164980586 99.4766901953356 a7150 gain_cnaBRCA61_(NOTCH2) 256 JW-7-24-1 LCK 3 45 2.32630161961136 NA 1.50753905440703 1.85957113358852 -0.35203207918149 0.453723387035373 1.19177515597413 0.301033313688138 0.775873779576729 0.295384643165972 0.616075590004043 NA NA NA 0.325333070816035 99.4766901953356 a7151 POLR2B_mut 229 LY317615 PRKCB (PKCbeta) 3 46 2.99573227355399 2.32630161961136 2.90088182501225 3.3884331533313 -0.487551328319052 2.06126776055609 1.59913262466468 0.300682298902039 0.236529837437287 0.304884861204859 0.616195797705272 NA NA NA 0.724089496677978 99.4766901953356 a7152 loss_cnaBRCA20 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 3 45 2.77258872223978 NA -0.0376586414529115 -0.463118438877484 0.425459797424573 1.14686311015633 1.42561755402784 0.30075472627633 0.370976966350044 0.298438944036925 0.616401237676282 NA NA NA 0.593017703644392 99.4766901953356 a7153 loss_cnaBRCA38 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 3 43 0 NA 1.23598969235569 0.612556456100444 0.62343323625525 0.210362425495266 2.11819996652933 0.301177640355996 2.96361498393771 0.294322182091591 0.616526506533012 NA NA NA 0.0786491176243983 99.4766901953356 a7154 MLL3_mut 1011 ABT-263 BCL2, BCL2L1, BCL2L2 3 40 0.693147180559945 NA 1.20986114956374 1.7173534620554 -0.507492312491656 2.33716990497774 1.63937568357479 0.302051509214877 0.217139674531488 0.30956437720549 0.616549146326455 NA NA NA 0.745102175310916 99.4766901953356 a7155 gain_cnaBRCA61_(NOTCH2) 178 BAY 61-3606 SYK 3 45 2.07944154167984 NA 3.55068375405987 3.06542409283372 0.485259661226151 2.29740728295473 1.5761978941171 0.300606456092497 0.211220563644271 0.30786721834695 0.61657458613907 NA NA NA 0.751317002534649 99.4766901953356 a7156 gain_cnaBRCA62 1230 IOX2 EGLN1 8 39 -2.30258509299405 NA 0.356114288472039 0.227585465916922 0.128528822555118 0.563736844864288 0.67281245197058 0.195619291522437 0.227994362486737 0.191032169780261 0.616712430872405 NA NA NA 0.581414186479188 99.4766901953356 a7157 loss_cnaBRCA20 292 Masitinib KIT 3 45 2.99573227355399 NA 3.70205384341916 4.03087895058848 -0.328825107169322 0.456483868767635 1.11513727664998 0.300359600690735 0.720343323537474 0.294874105686033 0.61686324341345 NA NA NA 0.352520491965012 99.4766901953356 a7158 gain_cnaBRCA16 269 NSC-207895 MDM4 16 33 2.99573227355399 NA 4.72720724141578 4.5441776276546 0.183029613761178 1.27555984928378 1.1530976777168 0.153349278181692 0.143489632308471 0.158728629237713 0.617044481742797 NA NA NA 0.631036576232881 99.4766901953356 a7159 gain_cnaBRCA16 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 15 30 2.30258509299405 NA 1.48295856028388 1.30650674285426 0.176451817429623 1.13881688152847 1.09276615414459 0.159256916334473 0.154943099537475 0.161472623177782 0.617102658770992 NA NA NA 0.623494979860569 99.4766901953356 a7160 gain_cnaBRCA13_(FGFR1,WHSC1L1) 178 BAY 61-3606 SYK 10 38 2.07944154167984 NA 3.32430989699134 3.03560622288904 0.288703674102294 1.71437948606787 1.58898492777918 0.178843033916113 0.168401264975743 0.181690630952552 0.617222681145788 NA NA NA 0.638340523318087 99.4766901953356 a7161 ARID1A_mut 256 JW-7-24-1 LCK 5 43 2.32630161961136 NA 1.58848958853035 1.86653186586169 -0.278042277331336 1.11919035101182 1.1741063972737 0.237758098478057 0.24843162477229 0.236811823849146 0.61723017971299 NA NA NA 0.62293923884786 99.4766901953356 a7162 ASH1L_mut 1241 CHIR-99021 GSK3B 3 43 2.30258509299405 NA 3.95542903322596 4.25074695708655 -0.295317923860582 0.633597861842933 0.996164308593249 0.300550311552389 0.466096781011219 0.296455033886549 0.617258775890328 NA NA NA 0.514581014234851 99.4766901953356 a7163 gain_cnaBRCA31 272 AR-42 HDAC 16 33 1.63315443905142 NA -0.0166845098284668 0.21889135007173 -0.235575859900197 1.98226856494072 1.27634706654705 0.153242683022565 0.118841545523495 0.184570377505163 0.61728858927342 NA NA NA 0.668833903508082 99.4766901953356 a7164 loss_cnaBRCA36_(FAT1,IRF2) 1006 Cytarabine DNA synthesis 8 37 0.693147180559945 NA 0.960699160121205 1.26211902931782 -0.301419869196613 1.27639709100168 1.58189135907887 0.196197940028205 0.236148978497019 0.190543976023821 0.617396976462784 NA NA NA 0.573346218393644 99.4766901953356 a7165 POLR2B_mut 302 PI-103 PI3Ka, PRKDC (DNAPK) 3 45 2.32630161961136 NA 0.604709731645436 1.16334805458869 -0.558638322943257 1.09782042327296 1.89036671217784 0.299870393680068 0.508861295618617 0.295518493498896 0.617435472210364 NA NA NA 0.482074381163162 99.4766901953356 a7166 gain_cnaBRCA8_(CHD4,WNK1) 345 KIN001-270 CDK9 4 45 2.99573227355399 NA 4.94049276455614 5.12243980805403 -0.181947043497895 1.00235062835111 0.667330358220677 0.262335334718066 0.181520356601364 0.272649132856815 0.617453147104209 NA NA NA 0.743705103314587 99.4766901953356 a7167 gain_cnaBRCA64_(SDHC) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 7 36 0.693147180559945 NA 1.97430774841081 1.62509910255643 0.349208645854384 1.53140286913019 1.70438246953674 0.207839880162928 0.228031860781825 0.204888663252504 0.617553329412543 NA NA NA 0.601030105824157 99.4766901953356 a7168 loss_cnaBRCA22_(SYNCRIP,ZNF292) 208 SB-715992 KIF11 19 30 -2.05572501506252 NA -1.39464336010593 -1.14189470175908 -0.25274865834685 1.75830509871699 1.68942357074435 0.14727823406026 0.143745621013826 0.149606447266206 0.617789935546892 NA NA NA 0.621591924999929 99.4766901953356 a7169 gain_cnaBRCA13_(FGFR1,WHSC1L1) 229 LY317615 PRKCB (PKCbeta) 11 38 2.99573227355399 2.32630161961136 3.14239254298248 3.4211645409334 -0.278771997950924 1.63073610227251 1.61902782846609 0.17191953300957 0.170948565842409 0.172184809334032 0.617921204742739 NA NA NA 0.623746051541201 99.4766901953356 a7170 gain_cnaBRCA47_(EGFR) 170 Shikonin unknown 7 40 2.77258872223978 NA -0.205233235733806 0.0401552246084768 -0.245388460342283 0.939418719556106 1.22683829473339 0.205772194263132 0.261213083403568 0.200016955287175 0.617943174285878 NA NA NA 0.557728911608188 99.4766901953356 a7171 BRCA1_mut 175 PAC-1 CASP3 agonist 4 44 0.940007258491471 NA 2.69667009853526 2.37453740981791 0.322132688717349 1.39741534359945 1.21590666055002 0.262203065911226 0.230520360458905 0.264932086622202 0.618005754640765 NA NA NA 0.682336562155157 99.4766901953356 a7172 gain_cnaBRCA10_(MDM2,NUP107) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 4 43 2.77258872223978 NA 4.76363787489125 5.03390274877951 -0.27026487388826 0.973905269606703 1.0337180678382 0.262434196742449 0.277506326665017 0.261449308372312 0.618089246474599 NA NA NA 0.627862700717561 99.4766901953356 a7173 MLL3_mut 190 Bleomycin DNA damage 3 45 4.15888308335967 NA 1.30485019561532 2.12996908704369 -0.825118891428376 1.82497337518431 2.7917848610365 0.299302158861362 0.452126536555661 0.295552462850606 0.618100441593508 NA NA NA 0.525007980393969 99.4766901953356 a7174 MACF1_mut 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 44 2.99573227355399 NA 3.44536108340446 3.87509199234246 -0.429730908938008 1.83263012005061 1.41341287903122 0.299537453748968 0.234488620609455 0.304037776444031 0.618126794608516 NA NA NA 0.726377501843126 99.4766901953356 a7175 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1259 BMN-673 PARP1 9 37 2.30258509299405 NA 3.54006735811229 3.24849036864413 0.291576989468163 1.47954773843098 1.58318213050772 0.186329023329871 0.197071700962736 0.184171475820445 0.618638008320851 NA NA NA 0.609959379179882 99.4766901953356 a7176 loss_cnaBRCA57 155 AP-24534 ABL 5 42 -0.669430653942629 NA 1.20373775960528 1.47412428487931 -0.270386525274027 1.02621353521122 1.15089419719175 0.23710553600688 0.263479788559186 0.234936040110191 0.618680402467855 NA NA NA 0.605142578082625 99.4766901953356 a7177 gain_cnaBRCA58_(CCND1) 288 KIN001-055 JAK3, MNK1 10 39 2.32630161961136 NA 4.46041724200422 4.30787615568189 0.152541086322335 0.843356941741758 0.863043395962876 0.177516078487142 0.180873695077789 0.176747875061542 0.618843043590255 NA NA NA 0.619341207632856 99.4766901953356 a7178 loss_cnaBRCA18 1203 QL-XII-61 BTK 6 17 2.30258509299405 NA 4.49562278198566 4.12977159904053 0.365851182945129 1.40992076048665 1.56024104530016 0.239777517746101 0.259483506590009 0.234483757523983 0.618855061984872 NA NA NA 0.607302087940918 99.4766901953356 a7179 BRCA1_mut 309 Y-39983 ROCK 4 45 2.99573227355399 NA 5.19615703543321 4.91176527319158 0.28439176224163 0.8658321944229 1.10205539101852 0.26126700681278 0.328460600187297 0.258055778828681 0.618882651609839 NA NA NA 0.572939631668442 99.4766901953356 a7180 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 344 THZ-2-49 CDK9 6 43 2.99573227355399 NA 1.50171244469014 1.82484186291272 -0.323129418222579 2.26782251908174 1.3570779062619 0.218207751712742 0.142484438488342 0.238106756238221 0.618915506294299 NA NA NA 0.746004419632566 99.4766901953356 a7181 loss_cnaBRCA28_(GPS2) 200 LAQ824 HDAC 4 44 0.0237165266173161 NA -3.02410528272845 -2.65359123962649 -0.370514043101958 0.629676520816618 1.45677042881155 0.261364172130274 0.588419658115001 0.254339349408834 0.619127317390678 NA NA NA 0.368852407173263 99.4766901953356 a7182 gain_cnaBRCA16 306 TG101348 JAK2 16 32 2.32630161961136 NA 3.35657148802679 3.15904765347229 0.197523834554507 1.44146501823594 1.20893426237853 0.153193411551649 0.137029918905862 0.163386745418139 0.619229789132765 NA NA NA 0.641272765584292 99.4766901953356 a7183 BRCA2_mut 1230 IOX2 EGLN1 5 42 -2.30258509299405 NA 0.110504477933087 0.266005359258829 -0.155500881325742 0.773600160960217 0.644566373016383 0.236660555760395 0.201009370438508 0.241248826863311 0.6193371982542 NA NA NA 0.684911271051084 99.4766901953356 a7184 loss_cnaBRCA20 1038 NU-7441 PRKDC (DNAPK) 3 40 0.693147180559945 NA 3.15765485009962 2.8730057780909 0.284649072008719 0.69334755011112 0.961254788397054 0.299649302746169 0.410543127992736 0.296122396938472 0.619346480406499 NA NA NA 0.560066440120476 99.4766901953356 a7185 loss_cnaBRCA38 228 KIN001-102 AKT1 4 45 2.32630161961136 NA 1.60510636878741 1.97380112728613 -0.368694758498721 1.13294931938336 1.43056426081671 0.26084903879585 0.325429171623841 0.257726806545714 0.619442330487181 NA NA NA 0.576093648260616 99.4766901953356 a7186 gain_cnaBRCA9_(KRAS) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 4 42 1.63315443905142 NA 2.31888596722058 1.90018630778465 0.418699659435928 1.34800287735394 1.6171777640196 0.261644137064812 0.310607392958844 0.258907628308729 0.619553137568324 NA NA NA 0.592405539409782 99.4766901953356 a7187 gain_cnaBRCA13_(FGFR1,WHSC1L1) 179 5-Fluorouracil DNA antimetabolite 11 38 3.46573590279973 NA 3.82579577108412 4.10391063770312 -0.278114866618996 1.44728457867265 1.67096791390149 0.171047099651724 0.192163221191829 0.166439381812924 0.619700994729944 NA NA NA 0.59471562060564 99.4766901953356 a7188 gain_cnaBRCA8_(CHD4,WNK1) 136 Mitomycin C DNA crosslinker 3 45 2.77258872223978 NA -0.549206145168225 -0.10664522842009 -0.442560916748135 1.67912523927907 1.47641247244865 0.29786010008906 0.263566353715312 0.299754252288415 0.619789442337396 NA NA NA 0.696019424242704 99.4766901953356 a7189 gain_cnaBRCA19 345 KIN001-270 CDK9 4 45 2.99573227355399 NA 4.94160112044094 5.12234128753094 -0.180740167089999 1.01851842400842 0.665686598054286 0.260585966812761 0.177453998700082 0.271509397392524 0.619794713080895 NA NA NA 0.749043695256891 99.4766901953356 a7190 loss_cnaBRCA29_(MAP2K4) 226 GSK1070916 AURKB 7 42 0.940007258491471 2.32630161961136 2.74587553948343 2.34695973749689 0.398915801986546 1.21899191737208 2.04290520216352 0.203826502331405 0.327250571805705 0.195268875699214 0.619917649765114 NA NA NA 0.487968516147031 99.4766901953356 a7191 loss_cnaBRCA20 153 Midostaurin KIT 3 44 -0.669430653942629 NA 1.02025326006495 0.584361164855798 0.43589209520915 0.52419396001299 1.49214431881589 0.297986985505327 0.831547344037212 0.292124622070778 0.619941213823 NA NA NA 0.302484962544482 99.4766901953356 a7192 loss_cnaBRCA7_(FAS,PTEN) 179 5-Fluorouracil DNA antimetabolite 4 45 3.46573590279973 NA 4.43038657494123 4.00690692033064 0.423479654610589 1.62868837797936 1.625775629915 0.260448725866706 0.260012695084116 0.260478535179377 0.619978581904699 NA NA NA 0.647440435530503 99.4766901953356 a7193 POLR2B_mut 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 3 40 1.6094379124341 NA 3.36697111703419 2.91432675845345 0.452644358580732 0.996061638711744 1.53540558473935 0.299059088936515 0.454434084185954 0.294804423716859 0.620034653442216 NA NA NA 0.524736401001045 99.4766901953356 a7194 CDH1_mut 292 Masitinib KIT 4 44 2.99573227355399 NA 3.74873325455636 4.03410866564804 -0.285375411091677 1.17951599046072 1.08867153582371 0.260658240684964 0.241942808236291 0.26213178328003 0.620071825886257 NA NA NA 0.668742203921356 99.4766901953356 a7195 BRCA2_mut 152 CP466722 ATM 6 43 2.77258872223978 NA 2.52662280216609 2.75853975488809 -0.231916952722006 1.19025128529952 1.05067968497836 0.217477250588208 0.194847050859218 0.220730405315471 0.620086884797333 NA NA NA 0.665938910239076 99.4766901953356 a7196 gain_cnaBRCA27_(CLTC,PPM1D) 202 GSK-1904529A IGF1R 9 39 0.0237165266173161 NA 2.06417111726369 2.21863672666548 -0.154465609401788 0.935521869610304 0.81463190345656 0.184566226176498 0.165111703338514 0.189613994672165 0.620089500661365 NA NA NA 0.65660865690626 99.4766901953356 a7197 loss_cnaBRCA33 186 Bexarotene Retinioic acid X family agonist 6 41 2.07944154167984 NA 3.8224889926887 3.57249079923493 0.249998193453774 0.397639600702927 1.20714740828602 0.218186243360686 0.628705473528894 0.207098314371347 0.620093323037457 NA NA NA 0.325656553859583 99.4766901953356 a7198 gain_cnaBRCA9_(KRAS) 333 T0901317 LXR 4 44 2.32630161961136 NA 4.91896126530994 4.7187521097315 0.200209155578441 0.775782612756033 0.767668066988807 0.260621172144865 0.25807378547346 0.260801724323073 0.620121440047217 NA NA NA 0.649857952364471 99.4766901953356 a7199 gain_cnaBRCA16 1 Erlotinib EGFR 3 9 0.693147180559945 NA 3.07553155650231 2.87691960725025 0.198611949252058 0.309584201753584 0.632604849541323 0.340958016273905 0.641544200663525 0.313958941977862 0.620147368525786 NA NA NA 0.493652628369824 99.4766901953356 a7200 BRCA2_mut 219 AT-7519 CDK9 6 43 2.32630161961136 NA 1.32477860746666 1.72045007023601 -0.39567146276935 1.85909154148179 1.81610894831737 0.217314762143303 0.212830543273829 0.217867690776999 0.620347574932739 NA NA NA 0.640637974378584 99.4766901953356 a7201 loss_cnaBRCA29_(MAP2K4) 172 Embelin XIAP 7 41 3.46573590279973 NA 2.82366684737919 3.02198333411177 -0.198316486732587 0.854837047359637 0.98896576736716 0.20392013709811 0.231993322405871 0.200529172269075 0.620414494296978 NA NA NA 0.593243090081698 99.4766901953356 a7202 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 9 38 2.32630161961136 NA 1.64711451432366 1.36242037754555 0.284694136778105 1.35966993134239 1.57667293829655 0.184826643123052 0.20938474126366 0.180566387525933 0.620508634434674 NA NA NA 0.593199612095156 99.4766901953356 a7203 loss_cnaBRCA22_(SYNCRIP,ZNF292) 167 OSU-03012 PDPK1 (PDK1) 18 30 2.77258872223978 NA 2.35847593140012 2.18168088529482 0.176795046105295 1.17698122196304 1.19730753237842 0.148587732418378 0.150210591984148 0.147660514382714 0.620592043145579 NA NA NA 0.619689769041379 99.4766901953356 a7204 gain_cnaBRCA12_(TERT) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 9 37 1.63315443905142 NA 1.69824458605461 1.99457209517151 -0.296327509116903 1.76031477673645 1.56251296482739 0.185170380959573 0.168337795622146 0.189648032232256 0.620815478360031 NA NA NA 0.652439138372259 99.4766901953356 a7205 MLL3_mut 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 3 40 -1.38629436111989 0.693147180559945 -1.95474424267149 -2.24044366825543 0.285699425583947 0.486876164699768 0.975689887443867 0.298333381249409 0.58680101080759 0.292817860736907 0.62088128176715 NA NA NA 0.431936860953743 99.4766901953356 a7206 gain_cnaBRCA58_(CCND1) 262 VX-11e ERK 10 39 1.63315443905142 NA 3.96460590974807 3.7286596458484 0.23594626389967 1.18145895992184 1.37125725268432 0.176474362170389 0.199707541187278 0.172065645186409 0.620897346549097 NA NA NA 0.593705088400166 99.4766901953356 a7207 loss_cnaBRCA36_(FAT1,IRF2) 194 AUY922 HSP90 9 38 -1.36257783450257 NA -2.65285539064303 -2.3323793158005 -0.320476074842533 1.93604260008279 1.68986766715479 0.184586354433889 0.165531520240737 0.189645663427666 0.620961814968398 NA NA NA 0.656462192665706 99.4766901953356 a7208 MLL3_mut 136 Mitomycin C DNA crosslinker 3 45 2.77258872223978 NA -0.547755812445231 -0.10674191726829 -0.441013895176941 1.57726581569641 1.48153912116077 0.296813278269332 0.279606576639221 0.297672797753333 0.621016824864288 NA NA NA 0.679759883316115 99.4766901953356 a7209 gain_cnaBRCA8_(CHD4,WNK1) 283 GSK2126458 PI3K, MTOR 4 44 -2.05572501506252 0.0237165266173161 -3.44648629926135 -3.01980077716578 -0.426685522095565 1.8171939332927 1.62911052772063 0.259851872692015 0.234804615114702 0.261913181969649 0.621151507085378 NA NA NA 0.677303641333781 99.4766901953356 a7210 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 12 31 1.6094379124341 NA 3.13058961840756 2.87441639575323 0.256173222654336 1.15391443907439 1.62565846244041 0.169248281959508 0.222003654672893 0.157581206983522 0.621279316623212 NA NA NA 0.567622101836768 99.4766901953356 a7211 ASH1L_mut 302 PI-103 PI3Ka, PRKDC (DNAPK) 3 45 2.32630161961136 NA 0.610431410605734 1.16296660932467 -0.552535198718938 1.0482435971234 1.89176000848304 0.296576593223516 0.527105722596553 0.292074679790913 0.621294485706285 NA NA NA 0.469426070347144 99.4766901953356 a7212 loss_cnaBRCA18 51 Dasatinib ABL, SRC, KIT, PDGFR 5 7 0.246860077931526 NA 2.16728254755711 1.82113053369476 0.34615201386235 0.927140312734269 1.29190831260863 0.298445512327299 0.373354506440884 0.267938529757887 0.621325648718574 NA NA NA 0.600787809397864 99.4766901953356 a7213 gain_cnaBRCA14_(RAD21) 1036 PLX4720 BRAF 19 24 2.30258509299405 NA 4.69974318663798 4.51497306924494 0.184770117393039 0.896882135694347 1.40554167076084 0.152844407603833 0.206013822819644 0.131458299128919 0.621330386604515 NA NA NA 0.603667783450776 99.4766901953356 a7214 loss_cnaBRCA28_(GPS2) 225 Genentech Cpd 10 AURKA, AURKB 4 45 2.32630161961136 NA 2.63174273069057 3.05240306610507 -0.420660335414497 0.554560876360098 1.6695660897285 0.259431777586686 0.758546722905396 0.251957881752919 0.621341803968662 NA NA NA 0.286982836042384 99.4766901953356 a7215 gain_cnaBRCA14_(RAD21) 344 THZ-2-49 CDK9 21 28 2.99573227355399 NA 1.66382854523446 1.87635983298086 -0.212531287746402 1.47587983751741 1.48458919946202 0.143515981083594 0.144003110784346 0.143158314652578 0.621398279847763 NA NA NA 0.621292940805114 99.4766901953356 a7216 PIK3CA_mut 164 JQ12 HDAC 16 31 1.63315443905142 NA 1.41132915248797 1.66384653585965 -0.252517383371677 1.84763092146286 1.54113497607136 0.1530742583403 0.136670901335504 0.163851568676607 0.621418287374733 NA NA NA 0.643021227519225 99.4766901953356 a7217 loss_cnaBRCA7_(FAS,PTEN) 287 KIN001-244 PDPK1 (PDK1) 4 45 2.99573227355399 NA 3.70355493821838 3.45806613995841 0.245488798259967 0.47949843472482 0.971008200319958 0.259149687781515 0.511969967953808 0.252818460419877 0.621720184238098 NA NA NA 0.417133885170635 99.4766901953356 a7218 gain_cnaBRCA27_(CLTC,PPM1D) 274 PXD101, Belinostat HDAC 9 39 2.99573227355399 NA 0.447173462980313 0.723271780500995 -0.276098317520682 1.76235425073741 1.44252944017035 0.183692323176165 0.156664482980738 0.191398740179665 0.621742292917921 NA NA NA 0.67059305098326 99.4766901953356 a7219 loss_cnaBRCA33 263 FR-180204 ERK 6 43 2.99573227355399 NA 5.21797440976138 5.37740728187322 -0.159432872111839 0.802455874444739 0.728424990452287 0.216428335743193 0.198681170129335 0.218873424445317 0.621770589313706 NA NA NA 0.660586886534699 99.4766901953356 a7220 gain_cnaBRCA47_(EGFR) 1243 piperlongumine Increases ROS levels 7 40 2.30258509299405 NA 1.56171536088495 1.73624023974234 -0.174524878857394 0.457535064456371 0.903809345756207 0.20345000323024 0.381445909647951 0.193099219074097 0.621903629906656 NA NA NA 0.448048536066382 99.4766901953356 a7221 BRCA2_mut 1022 AZD7762 CHEK1, CHEK2 5 40 0.693147180559945 NA 0.563135024775987 0.947452643223721 -0.384317618447733 1.57866219179932 1.63651183678604 0.235601770377514 0.243445127427609 0.234839498138001 0.62193604927413 NA NA NA 0.630475601194923 99.4766901953356 a7222 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 303 PIK-93 PI4K, PI3K 7 42 2.99573227355399 NA 2.54339030944409 2.83288334803817 -0.289493038594079 1.29789923643573 1.44690600665278 0.202619881053894 0.223047391097233 0.20007729407647 0.621985254355177 NA NA NA 0.604666733574079 99.4766901953356 a7223 gain_cnaBRCA8_(CHD4,WNK1) 1218 JQ1 BRD2, BRD3, BRD4 3 43 0 NA 2.26248816382729 2.47162096792685 -0.209132804099562 0.475481050533959 0.714774615531071 0.296364729769769 0.439834150834632 0.292585662047019 0.622154578794553 NA NA NA 0.535555831086816 99.4766901953356 a7224 loss_cnaBRCA29_(MAP2K4) 1529 MLN4924 NEDD8-activating enzyme 6 31 0 NA 0.0515080345505577 0.430706995794731 -0.379198961244173 2.53303440593497 1.53074430197662 0.221717862302605 0.149701464913268 0.247721948567452 0.622216930204627 NA NA NA 0.735734186544584 99.4766901953356 a7225 BRCA2_mut 1020 Lenalidomide TNFA 5 40 1.6094379124341 NA 4.10533418966239 4.27340062528686 -0.168066435624473 0.649923121496677 0.720268512656056 0.235381502127632 0.258594332261085 0.233338585085044 0.622260887273252 NA NA NA 0.612112438207839 99.4766901953356 a7226 loss_cnaBRCA60 1264 SGC0946 Q8TEK3 (DOT1L) 3 43 -0.693147180559945 NA 2.11966064244859 1.93892666477733 0.180733977671261 0.318838381203922 0.620532592712077 0.296253860342008 0.566851384042335 0.291256220533641 0.622284497548256 NA NA NA 0.443388264660565 99.4766901953356 a7227 loss_cnaBRCA20 1114 Cetuximab EGFR 3 42 4.18661983833127 NA 6.03847704771474 6.30002134137725 -0.26154429366251 1.46772272929754 0.843446584087785 0.296423953675989 0.178197345071904 0.310089931712011 0.622411753680851 NA NA NA 0.787965543149058 99.4766901953356 a7228 loss_cnaBRCA28_(GPS2) 1028 VX-702 p38 3 42 0.693147180559945 NA 3.23669752633119 3.44041242505296 -0.203714898721772 1.09116313762347 0.661392063638252 0.296370380614071 0.186695180305906 0.308009288168892 0.622474478538881 NA NA NA 0.778467897589489 99.4766901953356 a7229 gain_cnaBRCA15 219 AT-7519 CDK9 22 27 2.32630161961136 NA 1.52918704339616 1.78836702630492 -0.259179982908756 1.94320383188783 1.71554894916366 0.14234493659194 0.133377661496767 0.15107699668675 0.622481401441008 NA NA NA 0.627194002952826 99.4766901953356 a7230 gain_cnaBRCA48 167 OSU-03012 PDPK1 (PDK1) 5 43 2.77258872223978 NA 1.9983586512063 2.27700465274454 -0.278646001538235 1.19313438134143 1.18956008594564 0.23418162682316 0.233541171804099 0.234242897715188 0.622520067315538 NA NA NA 0.642077297851463 99.4766901953356 a7231 gain_cnaBRCA64_(SDHC) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 8 37 -0.669430653942629 NA -3.09771348593561 -3.5701867343947 0.472473248459092 3.1292211370059 2.28678124411815 0.193335998190023 0.150987491063403 0.206610601549381 0.622523607139989 NA NA NA 0.695728898138599 99.4766901953356 a7232 loss_cnaBRCA7_(FAS,PTEN) 196 Phenformin AAPK1 (AMPK) agonist 3 45 8.29404964010203 NA 7.70633953216364 7.1683913208429 0.537948211320742 0.598716310761461 1.85699782215796 0.295500390179136 0.898502682575272 0.289687044810645 0.622557707156443 NA NA NA 0.275898310139679 99.4766901953356 a7233 gain_cnaBRCA9_(KRAS) 1025 SB 216763 GSK3A, GSK3B 3 36 2.30258509299405 NA 5.10709605176671 4.87100010670086 0.236095945065851 0.334904369645319 0.809862925453153 0.298285541124181 0.704965257144566 0.291525809671736 0.622564560592415 NA NA NA 0.368946502263447 99.4766901953356 a7234 gain_cnaBRCA12_(TERT) 190 Bleomycin DNA damage 9 39 4.15888308335967 NA 2.48884966354368 1.98367980851074 0.505169855032932 3.50760083095074 2.57120896586487 0.183231656767427 0.144021477750649 0.196471722734137 0.62261433505513 NA NA NA 0.692140292395654 99.4766901953356 a7235 loss_cnaBRCA23 238 CAL-101 PI3Kdelta 3 46 2.99573227355399 2.32630161961136 4.45585439956114 4.73612355551056 -0.280269155949417 1.34953925891846 0.928274147605531 0.295016016843028 0.207677660429107 0.3019249826922 0.622840985455331 NA NA NA 0.755214849616922 99.4766901953356 a7236 gain_cnaBRCA14_(RAD21) 256 JW-7-24-1 LCK 21 27 2.32630161961136 NA 1.74281337273193 1.91126804990126 -0.168454677169328 1.2077101715199 1.13930184602885 0.144035434445072 0.139482701348228 0.14785781112924 0.622928356103163 NA NA NA 0.625731895582211 99.4766901953356 a7237 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1004 Vinblastine Microtubules 6 39 -2.30258509299405 NA -3.21276910583261 -3.49291285562223 0.280143749789621 1.41352319437554 1.27290670056915 0.21715808806543 0.198188293552113 0.220081919330271 0.622982477154266 NA NA NA 0.662470617303007 99.4766901953356 a7238 loss_cnaBRCA24 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 44 2.99573227355399 NA 4.24437657542675 3.82061366334094 0.423762912085803 1.67447912244996 1.42262660597255 0.295354742876066 0.253071481396429 0.297873602466548 0.623027047736635 NA NA NA 0.706971002930888 99.4766901953356 a7239 gain_cnaBRCA58_(CCND1) 1021 Axitinib PDGFR, KIT, VEGFR 9 36 0.693147180559945 NA 2.63599899651671 2.41894007664941 0.217058919867299 1.31603856796257 1.14226343533339 0.184489402257719 0.164933555255405 0.190025271888308 0.623094209848772 NA NA NA 0.658565293184042 99.4766901953356 a7240 gain_cnaBRCA31 1373 Dabrafenib BRAF 14 32 2.30258509299405 NA 4.39576004867204 4.13532685528755 0.260433193384493 0.96130813979172 1.8564231779401 0.158461924155868 0.270915414739877 0.140287622175388 0.623398260671989 NA NA NA 0.535393738124333 99.4766901953356 a7241 CDH1_mut 346 THZ-2-102-1 CDK7 4 44 0.916290731874155 2.99573227355399 -1.94023827960684 -1.28015030768534 -0.6600879719215 2.18346303689658 2.58114652052549 0.258139630674367 0.302312409583862 0.255734405882202 0.623446896661681 NA NA NA 0.600915902100569 99.4766901953356 a7242 gain_cnaBRCA14_(RAD21) 333 T0901317 LXR 21 27 2.32630161961136 NA 4.79758390674385 4.68709910547426 0.110484801269591 0.90228896792194 0.646478664805107 0.14381562216698 0.122449464858302 0.170902471008689 0.62345760222534 NA NA NA 0.638194136149708 99.4766901953356 a7243 loss_cnaBRCA29_(MAP2K4) 344 THZ-2-49 CDK9 7 42 2.99573227355399 NA 1.52919410411727 1.82795514391826 -0.298761039800986 1.30651898385211 1.50476558300741 0.201737990121593 0.228669497721438 0.198543243661836 0.62349836889325 NA NA NA 0.597520176629073 99.4766901953356 a7244 loss_cnaBRCA29_(MAP2K4) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 7 40 0.940007258491471 NA 1.67156279927342 1.92665048471897 -0.255087685445542 1.47010477714545 1.22404176977036 0.202509937365226 0.173516669975629 0.208397860061097 0.62351012800371 NA NA NA 0.676780493074575 99.4766901953356 a7245 gain_cnaBRCA30_(CRNKL1,FOXA2) 298 OSI-930 KIT, VEGFR, PDGFR 5 43 2.32630161961136 NA 4.09703109514602 3.892011040779 0.205020054367027 1.07978099388063 0.856500887234651 0.233462011520545 0.189871886548221 0.239369342662291 0.623586885206739 NA NA NA 0.700288326173486 99.4766901953356 a7246 gain_cnaBRCA63 175 PAC-1 CASP3 agonist 6 42 0.940007258491471 NA 2.16963783387616 2.43448808149696 -0.264850247620793 1.83633138746487 1.13247424764472 0.215558486526788 0.144227915194779 0.233868671337665 0.62372244116591 NA NA NA 0.743444118385136 99.4766901953356 a7247 loss_cnaBRCA60 1072 BMS-708163 g-secretase 3 43 1.6094379124341 NA 3.4195793013338 3.70271515037071 -0.283135849036908 1.20217029622106 0.946759329755894 0.29498096407388 0.235520583004692 0.299057891629027 0.623776971080501 NA NA NA 0.72542548128223 99.4766901953356 a7248 gain_cnaBRCA62 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 7 36 1.6094379124341 NA 2.84289069287189 2.51376236806427 0.329128324807625 2.78655767289887 1.30911561659373 0.204143676745437 0.11811287023004 0.251412725228964 0.623803098622521 NA NA NA 0.769136504509354 99.4766901953356 a7249 loss_cnaBRCA38 1192 GSK269962A ROCK1, ROCK2 3 43 1.6094379124341 NA 2.26233233461346 2.69624210114623 -0.433909766532768 1.00430260219353 1.48978164499437 0.294937148322376 0.432050823710953 0.291257291288757 0.623828373642118 NA NA NA 0.541934486341058 99.4766901953356 a7250 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 196 Phenformin AAPK1 (AMPK) agonist 7 41 8.29404964010203 NA 7.5159743715627 7.14840993740201 0.367564434160687 2.66599910962162 1.65687290206281 0.201902821371111 0.137871176638485 0.221842263038444 0.623867520671032 NA NA NA 0.734535271779975 99.4766901953356 a7251 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 165 DMOG Prolyl-4-Hydroxylase 5 41 8.29404964010203 NA 7.24837112144244 7.60920124329997 -0.360830121857534 1.68807006027766 1.52771323171619 0.233852764262034 0.213753048731984 0.236189694745385 0.623991588251301 NA NA NA 0.668309942356349 99.4766901953356 a7252 PTEN_mut 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 37 1.6094379124341 NA 2.26578947097366 2.61624171012364 -0.350452239149986 0.731243834627584 1.69884784430962 0.217369178064745 0.479254966065414 0.20628818544512 0.62401156466924 NA NA NA 0.404044461327826 99.4766901953356 a7253 gain_cnaBRCA64_(SDHC) 1058 GDC0941 PI3K (class 1) 7 36 1.38629436111989 0.693147180559945 1.58413476269468 1.2996990875442 0.284435675150482 1.25010008010262 1.41742800267034 0.204014130936797 0.227530323113916 0.200670280687714 0.624022656506212 NA NA NA 0.602954099248857 99.4766901953356 a7254 gain_cnaBRCA62 277 ABT-869 VEGFR and PDGFR family 10 38 0.0237165266173161 NA 2.62475854531944 2.70853080124188 -0.0837722559224399 0.705181897458198 0.403535470769044 0.175336009403855 0.118795244495631 0.207595767883278 0.624122745076041 NA NA NA 0.725588383257207 99.4766901953356 a7255 gain_cnaBRCA58_(CCND1) 326 GSK690693 AKT 10 38 2.32630161961136 NA 2.67043323162204 3.01040588705867 -0.339972655436629 1.83014664203734 1.96491071858221 0.175308621198751 0.185762521771572 0.173021935409838 0.624176766656025 NA NA NA 0.614387016166317 99.4766901953356 a7256 ASH1L_mut 208 SB-715992 KIF11 3 46 -2.05572501506252 NA -1.71328974569798 -1.2090259925585 -0.50426375313948 1.42178963553736 1.72822242724466 0.293809035962086 0.35466832823612 0.291781743593872 0.62426061561762 NA NA NA 0.607877175112093 99.4766901953356 a7257 loss_cnaBRCA20 326 GSK690693 AKT 3 45 2.32630161961136 NA 3.47407822788691 2.9039449186842 0.570133309202707 1.31952693055768 1.96281211513642 0.293991438823295 0.432074022893755 0.290467592290708 0.624330812153134 NA NA NA 0.541466146131817 99.4766901953356 a7258 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1018 ABT-888 PARP1, PARP2 6 39 1.6094379124341 NA 4.27791425945264 4.42233187395567 -0.144417614503035 0.89694302951546 0.631591004118072 0.216231363920403 0.16101091122928 0.228656857937193 0.624462491832219 NA NA NA 0.717384877272373 99.4766901953356 a7259 gain_cnaBRCA47_(EGFR) 1230 IOX2 EGLN1 7 40 -2.30258509299405 NA 0.362394575962869 0.229699636169904 0.132694939792965 0.493750989684949 0.67876828505478 0.201935311606149 0.268748706463626 0.195493724021381 0.624493031064473 NA NA NA 0.550832891476138 99.4766901953356 a7260 CDH1_mut 166 FTI-277 Farnesyl transferase (FNTA) 4 43 0.0237165266173161 NA 2.05130105070576 2.26234948500527 -0.211048434299517 0.148491251868895 0.846985345082199 0.257639020106007 1.4212853056546 0.249176016474092 0.624505301289152 NA NA NA 0.167108856134469 99.4766901953356 a7261 gain_cnaBRCA61_(NOTCH2) 257 NPK76-II-72-1 PLK3 3 46 2.32630161961136 NA 3.91784002997382 3.45033770579202 0.467502324181796 1.16485276755516 1.60875165380636 0.293586215903987 0.401340269949317 0.290599436572867 0.624522850466248 NA NA NA 0.566812462778007 99.4766901953356 a7262 loss_cnaBRCA22_(SYNCRIP,ZNF292) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 18 29 2.32630161961136 NA 1.27638512476098 1.50417492172229 -0.227789796961305 1.63022463854752 1.4832584928871 0.147874367161565 0.139729084921853 0.153573903708397 0.624543259072616 NA NA NA 0.633059070439789 99.4766901953356 a7263 PIK3CA_mut 135 Gemcitabine DNA replication 17 30 0.0237165266173161 NA -0.540351315975893 -0.124984764198019 -0.415366551777873 3.18082514674164 2.52728676743924 0.149556010039247 0.130584528421301 0.164352758511351 0.624653977904525 NA NA NA 0.6476583703163 99.4766901953356 a7264 loss_cnaBRCA34 164 JQ12 HDAC 5 42 1.63315443905142 NA 1.23445799103246 1.61876712134034 -0.384309130307875 1.18414850735641 1.68828963394819 0.232953105478461 0.324544706952203 0.227632227658201 0.624821610555265 NA NA NA 0.538542800072803 99.4766901953356 a7265 loss_cnaBRCA34 1371 PLX4720 (rescreen) BRAF 5 42 2.30258509299405 NA 4.50705363115629 4.73096802385226 -0.223914392695966 0.472702018315545 0.996149217151925 0.232944878044822 0.473690367335168 0.224779971555021 0.624833805426257 NA NA NA 0.413610915276322 99.4766901953356 a7266 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 11 Paclitaxel Microtubules 3 9 -2.27886856637673 NA -3.55466572479832 -2.94071707137453 -0.613948653423785 2.00496086908355 1.77808325857143 0.33627835174589 0.306214780991919 0.345286785905094 0.624895944607213 NA NA NA 0.667811186888714 99.4766901953356 a7267 gain_cnaBRCA27_(CLTC,PPM1D) 11 Paclitaxel Microtubules 3 9 -2.27886856637673 NA -3.55466572479832 -2.94071707137453 -0.613948653423785 2.00496086908355 1.77808325857143 0.33627835174589 0.306214780991919 0.345286785905094 0.624895944607213 NA NA NA 0.667811186888714 99.4766901953356 a7268 gain_cnaBRCA15 271 VNLG/124 HDAC, RAR 22 27 1.63315443905142 NA 4.0878044044105 4.20329141773602 -0.115487013325515 0.951297058929454 0.689983325632945 0.141331759348438 0.121399527352138 0.167376527859676 0.624954068347754 NA NA NA 0.636571711014365 99.4766901953356 a7269 gain_cnaBRCA10_(MDM2,NUP107) 1194 SB-505124 TGFR1 (ALK5) 3 44 2.30258509299405 NA 4.64270009712918 4.37170129325294 0.270998803876241 0.785164884613348 0.928607118467205 0.293700200728135 0.345148909721928 0.291833649007087 0.624970215552571 NA NA NA 0.616898709137132 99.4766901953356 a7270 ARID1A_mut 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 5 42 2.32630161961136 NA 1.09640292716943 1.4550950080904 -0.358692080920969 1.01436438711031 1.58242633499705 0.232850684935341 0.353612651901946 0.226672214047573 0.624973427951783 NA NA NA 0.510040804937898 99.4766901953356 a7271 loss_cnaBRCA36_(FAT1,IRF2) 157 JNK-9L JNK 9 38 1.63315443905142 NA -0.100683071438682 0.092916569493969 -0.193599640932651 0.975003712573578 1.07879649893231 0.182454114704315 0.19856297820819 0.179458907332623 0.624989682725795 NA NA NA 0.608719700893884 99.4766901953356 a7272 gain_cnaBRCA61_(NOTCH2) 166 FTI-277 Farnesyl transferase (FNTA) 3 44 0.0237165266173161 NA 2.46959581347217 2.22903283221894 0.240562981253233 0.173658668153314 0.837166348720475 0.293666834773879 1.38526330883093 0.28735385938638 0.625009429805306 NA NA NA 0.161475009045664 99.4766901953356 a7273 POLR2B_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 43 1.38629436111989 NA 3.26771545466776 2.83006695019933 0.437648504468426 1.24108410379531 1.49974447584043 0.293928529873151 0.352634042390899 0.291815380232139 0.62501216035826 NA NA NA 0.610207253495072 99.4766901953356 a7274 loss_cnaBRCA20 231 FMK RSK 3 46 2.99573227355399 2.32630161961136 5.42513707338649 5.59993139023583 -0.174794316849337 0.244049469420734 0.607212582523114 0.293140475532551 0.716224941050773 0.28786346311044 0.625047585456249 NA NA NA 0.355396464271328 99.4766901953356 a7275 MACF1_mut 1038 NU-7441 PRKDC (DNAPK) 3 40 0.693147180559945 NA 3.15329148637053 2.87333303037059 0.279958455999945 0.629883641034821 0.963590581912451 0.294682072407293 0.444460592023009 0.290536729244808 0.625148874154035 NA NA NA 0.532962171746585 99.4766901953356 a7276 gain_cnaBRCA31 1031 Elesclomol HSP70 13 31 -1.6094379124341 NA -2.77195124335175 -3.06381009488839 0.291858851536642 1.39105589109796 1.93299806603713 0.162601568362676 0.209811017231146 0.150987658324453 0.625213047552886 NA NA NA 0.577918977239067 99.4766901953356 a7277 gain_cnaBRCA19 1030 KU-55933 ATM 3 39 2.30258509299405 NA 4.47624635645133 4.20276497032455 0.273481386126785 0.478602290238287 0.945272505452915 0.294848378868275 0.571416793661025 0.289314863755346 0.625327862141151 NA NA NA 0.442884842789582 99.4766901953356 a7278 loss_cnaBRCA18 173 FH535 unknown 16 32 3.46573590279973 NA 1.70207950840846 1.50845735109167 0.193622157316787 0.849458755038962 1.45145480608632 0.150504745345378 0.227935913507544 0.133398681450418 0.625377399664573 NA NA NA 0.563938851217844 99.4766901953356 a7279 gain_cnaBRCA10_(MDM2,NUP107) 1008 Methotrexate Dihydrofolate reductase (DHFR) 3 42 -1.6094379124341 NA 0.98300444076828 0.661196191139975 0.321808249628305 0.84434845061123 1.10615604810965 0.293790241109367 0.381132042577145 0.290924820397859 0.625498730680019 NA NA NA 0.5850412365734 99.4766901953356 a7280 loss_cnaBRCA28_(GPS2) 344 THZ-2-49 CDK9 4 45 2.99573227355399 NA 1.43664048873735 1.81626472929863 -0.379624240561282 0.691429590497895 1.51995045419588 0.256333112794657 0.549042513913696 0.249760931031216 0.62550383643997 NA NA NA 0.393519351363008 99.4766901953356 a7281 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 345 KIN001-270 CDK9 7 42 2.99573227355399 NA 5.22679123967153 5.08771961292751 0.139071626744026 1.06409137043323 0.621180090192537 0.200491927920356 0.130695192732748 0.223882943030129 0.625639112189667 NA NA NA 0.746885903446064 99.4766901953356 a7282 NF1_mut 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 5 41 0 NA 0.22384703366654 0.705577110269597 -0.481730076603057 2.40207998696417 2.03413804330117 0.232687105574231 0.200547058889527 0.23682270639866 0.625716769322311 NA NA NA 0.68607123806383 99.4766901953356 a7283 loss_cnaBRCA34 290 KIN001-260 IKK 5 44 2.99573227355399 NA 4.82630596857132 5.06881996074343 -0.242513992172107 0.860863203045483 1.06263316749605 0.231632767699805 0.281710254677123 0.228219859486936 0.625844814932454 NA NA NA 0.583916205942295 99.4766901953356 a7284 gain_cnaBRCA14_(RAD21) 1218 JQ1 BRD2, BRD3, BRD4 20 26 0 NA 2.51621986268672 2.41318341763854 0.103036445048182 0.797700676112935 0.626817955326819 0.146005448434533 0.129166801700936 0.164380174774124 0.625937702022115 NA NA NA 0.637264764661983 99.4766901953356 a7285 CDH1_mut 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 4 41 2.30258509299405 NA 1.62495913702077 1.33999375955617 0.284965377464604 1.20809400740728 1.10026796260677 0.257158512330408 0.235880134921102 0.258996341936068 0.625974597290833 NA NA NA 0.676666067425389 99.4766901953356 a7286 gain_cnaBRCA12_(TERT) 176 IPA-3 PAK1, PAK2, PAK3 9 38 3.46573590279973 NA 4.27387368439146 4.54964713133286 -0.2757734469414 1.61491553785255 1.49510431129967 0.181777215188011 0.170766483124011 0.184450974328122 0.62627079982722 NA NA NA 0.649186743818603 99.4766901953356 a7287 gain_cnaBRCA13_(FGFR1,WHSC1L1) 133 Doxorubicin DNA intercalating 10 38 0.0237165266173161 NA -0.776246991427107 -1.09759182356206 0.321344832134951 1.89166178357172 1.8325212339476 0.174242278807844 0.169874358580215 0.175356675918409 0.626281682716113 NA NA NA 0.638015680097939 99.4766901953356 a7288 ASH1L_mut 292 Masitinib KIT 3 45 2.99573227355399 NA 4.31036404851119 3.99032493691568 0.320039111595517 1.07595233309412 1.09578544313582 0.29229168529973 0.297447295527655 0.292063664105318 0.626330814908771 NA NA NA 0.662174901368578 99.4766901953356 a7289 loss_cnaBRCA24 308 XL-880 MET 3 46 1.63315443905142 NA 1.40581909189944 1.87654942935626 -0.47073033745682 1.55881840749908 1.61446455273318 0.291991747319073 0.301978944559709 0.291570562301851 0.626400796571161 NA NA NA 0.65764435104824 99.4766901953356 a7290 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1091 BMS-536924 IGF1R 8 39 1.38629436111989 NA 2.84973792386306 3.05890515157015 -0.209167227707095 1.06789481256341 1.10584809139392 0.19014679515473 0.19586875528031 0.189146438226827 0.626576767021649 NA NA NA 0.626486983681428 99.4766901953356 a7291 gain_cnaBRCA10_(MDM2,NUP107) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 42 2.30258509299405 NA 2.81899863263137 3.20242900290337 -0.383430370271999 0.815354830128935 1.32861683872178 0.29287073691077 0.47026197197037 0.28859364046664 0.62657808922282 NA NA NA 0.512442698254566 99.4766901953356 a7292 gain_cnaBRCA14_(RAD21) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 21 27 2.77258872223978 NA -0.323118112737328 -0.524734270605986 0.201616157868658 1.07433541457534 1.62906954085761 0.142498735388545 0.187665932941764 0.123761541672751 0.626632494239732 NA NA NA 0.609065977579661 99.4766901953356 a7293 loss_cnaBRCA18 253 XMD14-99 EPHB3, CAMK1 15 33 2.32630161961136 NA 4.85164866880191 4.97012600905073 -0.118477340248823 0.595819333923821 0.844050711539128 0.152491562743028 0.198847760559531 0.140367561603946 0.626675356566951 NA NA NA 0.580881516769066 99.4766901953356 a7294 gain_cnaBRCA16 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 3 11 1.38629436111989 NA 1.71139086076592 1.97763624837979 -0.266245387613869 1.21060214544163 0.715345250689409 0.325102677563418 0.219928065232976 0.372191452109701 0.626712338146807 NA NA NA 0.745550773700569 99.4766901953356 a7295 gain_cnaBRCA48 258 STF-62247 stimulates autophagy 5 44 2.32630161961136 NA 4.83124801168337 4.60806959784788 0.223178413835495 0.716980763256845 0.985971857846026 0.23103367229322 0.311275316260536 0.226353736224333 0.626736252097626 NA NA NA 0.551473891972652 99.4766901953356 a7296 gain_cnaBRCA14_(RAD21) 1494 SN-38 TOP1 22 26 -2.99573227355399 NA -3.17384213822961 -3.41374313212619 0.239900993896577 2.02933673534551 1.34449516672095 0.141794988483929 0.118216454528297 0.178432024030004 0.626825406885728 NA NA NA 0.638775726432885 99.4766901953356 a7297 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1203 QL-XII-61 BTK 5 18 2.30258509299405 NA 4.5230239671719 4.14248522443019 0.380538742741711 1.23590131404287 1.58682339695998 0.249335012839372 0.307903825667841 0.239811653565698 0.626975504042413 NA NA NA 0.583997845585823 99.4766901953356 a7298 gain_cnaBRCA19 1114 Cetuximab EGFR 4 41 4.18661983833127 NA 6.48869414011599 6.26247685172011 0.22621728839588 0.922140133872992 0.879345124299004 0.256366450900053 0.245317690973677 0.257256544836381 0.627035686091236 NA NA NA 0.66558137355753 99.4766901953356 a7299 POLR2B_mut 186 Bexarotene Retinioic acid X family agonist 3 44 2.07944154167984 NA 3.91755246524875 3.58305453020495 0.334497935043794 1.34050875690547 1.13606558188744 0.291901678832782 0.249530585548709 0.294435409695333 0.627085539887847 NA NA NA 0.710726858614216 99.4766901953356 a7300 CDH1_mut 1192 GSK269962A ROCK1, ROCK2 5 41 1.6094379124341 NA 2.36411394462324 2.70499603975639 -0.340882095133152 1.36126166636713 1.48182431846596 0.231692037998908 0.250416289208291 0.230042179012183 0.627191154154713 NA NA NA 0.622113077057996 99.4766901953356 a7301 NF1_mut 255 CP724714 ERBB2 4 44 2.32630161961136 NA 3.41064185789548 3.83870785133996 -0.428065993444478 2.22414181242182 1.63187642895077 0.255273602539731 0.192463444126509 0.262315200985964 0.627297481889415 NA NA NA 0.729911953593182 99.4766901953356 a7302 loss_cnaBRCA20 305 TPCA-1 IKK 3 46 2.99573227355399 NA 3.79895295892264 4.20306810957612 -0.404115150653479 1.2738559870785 1.39256232615867 0.291208437814416 0.31723770563758 0.29019537801817 0.627324286904172 NA NA NA 0.642922340193033 99.4766901953356 a7303 CDH1_mut 1248 FK866 NAMPT 5 39 0 NA -0.0895442699296786 -0.722649665293857 0.633105395364179 2.88239511736711 2.7120333900646 0.232015810898312 0.219645596660073 0.233443068099209 0.627780954353012 NA NA NA 0.661364763305593 99.482402686627 a7304 gain_cnaBRCA14_(RAD21) 1026 17-AAG HSP90 19 24 0 NA -1.04659547926482 -0.777148827236663 -0.269446652028161 1.34391779342655 2.08304728252777 0.149992639405406 0.200493403202261 0.129352153591631 0.627835104927499 NA NA NA 0.61079080350707 99.482402686627 a7305 ASH1L_mut 1030 KU-55933 ATM 3 39 2.30258509299405 NA 3.97023361314641 4.24168902750185 -0.271455414355436 1.09492113558647 0.917921212423042 0.292651041713057 0.247922343932138 0.295728446713714 0.62789973186663 NA NA NA 0.712763962957755 99.482402686627 a7306 loss_cnaBRCA17 282 EKB-569 EGFR 10 37 0.916290731874155 2.99573227355399 1.8691908101431 1.49938546338981 0.369805346753292 1.83865560056061 2.19273438278783 0.173891833242373 0.201128121351566 0.168650316087589 0.627989287126003 NA NA NA 0.59597552461018 99.482402686627 a7307 PIK3CA_mut 1024 CEP-701 FLT3, JAK2, NTRK1, RET 16 29 0.693147180559945 NA 0.766937855516215 0.547572269577493 0.219365585938721 1.51006374932874 1.40635493860903 0.151980586163769 0.145269089491245 0.155981665734887 0.628012445773769 NA NA NA 0.636294896885186 99.482402686627 a7308 loss_cnaBRCA17 185 OSI-906 IGF1R 11 37 0.940007258491471 NA 2.7471198150396 2.93700534700553 -0.189885531965933 1.19476230202675 1.11592910288766 0.167516510872761 0.158931639911821 0.170159135983255 0.62801449287378 NA NA NA 0.645072004791899 99.482402686627 a7309 loss_cnaBRCA36_(FAT1,IRF2) 211 TL-2-105 CRAF 9 40 2.32630161961136 1.63315443905142 4.06810834695816 3.87142894917102 0.196679397787142 0.692679063427298 1.15885458959574 0.179840895449083 0.283940150888919 0.169718789184546 0.628196312503261 NA NA NA 0.512375173268578 99.482402686627 a7310 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 277 ABT-869 VEGFR and PDGFR family 6 42 0.0237165266173161 NA 2.60220366101599 2.70377461748309 -0.101570956467102 0.265460553807389 0.497547510094172 0.212574713438919 0.38262165512093 0.204143231362724 0.628521843742969 NA NA NA 0.460583466866162 99.482402686627 a7311 loss_cnaBRCA38 175 PAC-1 CASP3 agonist 4 44 0.940007258491471 NA 2.11488745923753 2.42742674066316 -0.312539281425632 0.756938625303518 1.2550753993816 0.254353528057824 0.412899105657754 0.249020323065552 0.62853586013614 NA NA NA 0.495569542533472 99.482402686627 a7312 loss_cnaBRCA7_(FAS,PTEN) 1017 Olaparib PARP1, PARP2 4 41 1.6094379124341 NA 3.86615410992158 4.09438531614913 -0.228231206227546 0.949677339950286 0.889881902290794 0.25523980391015 0.240324999477711 0.256473590079782 0.628546380724333 NA NA NA 0.67152521396102 99.482402686627 a7313 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 291 KIN001-266 MAP3K8 (COT) 7 42 2.99573227355399 NA 3.98060516408232 3.74497261644168 0.235632547640639 1.61043095656966 1.10996700625838 0.198732469365901 0.146316454412025 0.212287884515541 0.628667426745946 NA NA NA 0.720467641658937 99.482402686627 a7314 loss_cnaBRCA34 1527 GDC0941 (rescreen) PI3K 5 40 1.38629436111989 NA 1.21921345231451 0.950836139994753 0.268377312319755 1.28315258405635 1.14919192230477 0.230900960056696 0.209154636521364 0.233535675904777 0.628884972099125 NA NA NA 0.674939527061276 99.482402686627 a7315 ASH1L_mut 1194 SB-505124 TGFR1 (ALK5) 3 44 2.30258509299405 NA 4.13817837052426 4.40610050188509 -0.267922131360832 1.2121177170171 0.90705947827797 0.29034815240749 0.221036395722489 0.295374380376329 0.628915269014946 NA NA NA 0.740896251838905 99.482402686627 a7316 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 4 39 0.693147180559945 NA 2.68574892029238 2.93125661897487 -0.245507698682493 0.797590651967583 0.972899223001873 0.255429445934298 0.307811655110109 0.252346484484776 0.629190485106281 NA NA NA 0.597215939040202 99.482402686627 a7317 gain_cnaBRCA58_(CCND1) 177 GSK-650394 SGK3 9 38 2.77258872223978 NA 4.26281773266624 3.95561222457845 0.307205508087795 1.17398220717044 1.79887454773348 0.180220597227772 0.261678163613936 0.170776504940193 0.62922131584524 NA NA NA 0.536977031156811 99.482402686627 a7318 PTEN_mut 263 FR-180204 ERK 9 40 2.99573227355399 NA 5.2500570409688 5.38214615525993 -0.132089114291131 1.00899350008105 0.66729670295576 0.179289626623728 0.130911759372603 0.19794660112368 0.629247411740862 NA NA NA 0.715979382619766 99.482402686627 a7319 gain_cnaBRCA16 266 Zibotentan, ZD4054 Endothelin A Receptor 16 33 2.99573227355399 NA 5.79135263606428 5.71812992920055 0.0732227068637323 0.649695291012675 0.4022830202906 0.147963231597139 0.112703151579875 0.182017890814377 0.629432926398902 NA NA NA 0.683138259486492 99.482402686627 a7320 gain_cnaBRCA62 170 Shikonin unknown 9 38 2.77258872223978 NA 0.177251260462534 -0.0375180265779046 0.214769287040439 1.21225456375867 1.18847851290314 0.180063790857859 0.177165170964202 0.180709440438947 0.629518877520093 NA NA NA 0.640124552409656 99.482402686627 a7321 loss_cnaBRCA60 272 AR-42 HDAC 3 46 1.63315443905142 NA -0.275667552307899 0.169205762000768 -0.444873314308667 0.792871233340767 1.5624349306351 0.28933830580703 0.561091505910979 0.284730778598141 0.62953153338393 NA NA NA 0.446739238451886 99.482402686627 a7322 loss_cnaBRCA28_(GPS2) 136 Mitomycin C DNA crosslinker 4 44 2.77258872223978 NA -0.479772570051947 -0.102899168959112 -0.376873401092835 0.23500358939728 1.53573129899811 0.253612395578458 1.60369210555214 0.245403216916072 0.629534176577782 NA NA NA 0.155562066076832 99.482402686627 a7323 BRCA2_mut 1377 Afatinib (rescreen) ERBB2, EGFR 5 42 2.30258509299405 NA 2.42437954343996 2.88348067602207 -0.45910113258211 1.79333658124723 2.0171746015546 0.229746602927711 0.256003885373718 0.227596129868128 0.629582370091389 NA NA NA 0.615257106205602 99.482402686627 a7324 loss_cnaBRCA36_(FAT1,IRF2) 306 TG101348 JAK2 9 39 2.32630161961136 NA 3.03680167193744 3.26829368390013 -0.231492011962683 1.10572546941786 1.32503996819167 0.179509566777005 0.209357583202418 0.17470568248489 0.62968024040745 NA NA NA 0.594868030368996 99.482402686627 a7325 NF1_mut 326 GSK690693 AKT 4 44 2.32630161961136 NA 3.39018179700801 2.89861429173677 0.491567505271236 2.01031635888413 1.93440195133203 0.253458021847106 0.244522461899525 0.254118594603744 0.629742208377944 NA NA NA 0.666147075807903 99.482402686627 a7326 TP53_mut 1264 SGC0946 Q8TEK3 (DOT1L) 36 10 -0.693147180559945 NA 1.97371901352539 1.86789440258569 0.105824610939704 0.606482998602889 0.624149948241905 0.173443642199682 0.174488998345352 0.169549979516603 0.629933832789649 NA NA NA 0.640520994682859 99.482402686627 a7327 gain_cnaBRCA16 225 Genentech Cpd 10 AURKA, AURKB 16 33 2.32630161961136 NA 2.85683937130559 3.09623269565457 -0.239393324348977 1.67601334497772 1.59557637380733 0.14762045267944 0.142834975071252 0.150035641213302 0.630225058318327 NA NA NA 0.637554379793487 99.482402686627 a7328 loss_cnaBRCA28_(GPS2) 260 NG-25 MAP3K7 (TAK1) 4 45 2.32630161961136 NA 2.90889182669089 3.23496132271839 -0.326069496027495 0.704902856705927 1.32210375932496 0.252463597680782 0.46257366235008 0.246629278320771 0.630718589449964 NA NA NA 0.455152901646652 99.482402686627 a7329 gain_cnaBRCA13_(FGFR1,WHSC1L1) 6 PHA-665752 MET 4 10 0.693147180559945 NA 2.70282557176595 2.92901983053589 -0.226194258769935 1.18760004258923 0.575439455836665 0.291785503818067 0.190463329958107 0.393080899259955 0.630768022844107 NA NA NA 0.736181137668283 99.482402686627 a7330 gain_cnaBRCA14_(RAD21) 163 JQ1 BRD4 21 26 0.940007258491471 NA 0.431002043080745 0.22296323426025 0.208038808820494 1.25582575462645 1.61413325518258 0.141934390987985 0.1656589762187 0.128885770832447 0.630898084996962 NA NA NA 0.621702127384453 99.482402686627 a7331 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 300 CX-5461 RNA Pol I 7 42 2.32630161961136 NA 4.20266163384718 3.86398256978648 0.338679064060703 0.967647468688069 1.80006167960214 0.19731672438317 0.350002531934365 0.188148588405904 0.631108848676379 NA NA NA 0.472833131489553 99.482402686627 a7332 BRCA2_mut 1053 MK-2206 AKT1, AKT2 5 37 1.38629436111989 0.693147180559945 1.72987351154652 1.34847439626355 0.381399115282969 0.78689638782376 1.72392963677305 0.230552166602113 0.484687846055268 0.221238214801443 0.631115389779648 NA NA NA 0.417635624620287 99.482402686627 a7333 gain_cnaBRCA15 176 IPA-3 PAK1, PAK2, PAK3 22 25 3.46573590279973 NA 4.38282637849597 4.59717095293042 -0.214344574434451 1.55914243094147 1.47954680427285 0.141275373736381 0.137475942018345 0.144871776827496 0.631240091832018 NA NA NA 0.632479278584873 99.482402686627 a7334 gain_cnaBRCA61_(NOTCH2) 288 KIN001-055 JAK3, MNK1 3 46 2.32630161961136 NA 4.10675888424277 4.35415360519364 -0.247394720950873 0.879955106617112 0.858545467372014 0.287846550798079 0.281144707372577 0.28815564271528 0.631294649111005 NA NA NA 0.678385898898984 99.482402686627 a7335 BRCA2_mut 1114 Cetuximab EGFR 5 40 4.18661983833127 NA 6.10274786771066 6.30506470356088 -0.202316835850223 0.83625868704307 0.887060951243963 0.229264974922734 0.241930922793276 0.228075461518745 0.631311398009412 NA NA NA 0.633255765226777 99.482402686627 a7336 gain_cnaBRCA63 275 I-BET BRD2, BRD3, BRD4 7 42 2.99573227355399 NA 3.80805639925068 4.07742183601197 -0.269365436761287 1.35036267881201 1.36825882224682 0.197194691326317 0.199476363637555 0.196867312223109 0.631319487230397 NA NA NA 0.638552709776238 99.482402686627 a7337 gain_cnaBRCA9_(KRAS) 1262 UNC1215 LMBL3 4 42 0 NA 2.89534271565872 2.74439436643497 0.150948349223757 0.108569785397022 0.617886224522672 0.252792542308782 1.39033478487374 0.244297968190449 0.631417666840133 NA NA NA 0.179222319468619 99.482402686627 a7338 gain_cnaBRCA61_(NOTCH2) 235 QL-XII-47 BTK, BMX 3 46 2.32630161961136 NA 1.29985748276855 1.73469798256315 -0.434840499794596 1.15947121791452 1.52536357656909 0.287669220905297 0.375033457558972 0.285073346757537 0.631504380906525 NA NA NA 0.589959925600712 99.482402686627 a7339 ARID1A_mut 261 TL-1-85 MAP3K7 (TAK1) 5 44 2.32630161961136 NA 4.27393454947861 3.99649645644999 0.277438093028623 1.03843548527401 1.23329142983947 0.227796227101795 0.267169310913346 0.224957448268926 0.631563194714409 NA NA NA 0.601462050200957 99.482402686627 a7340 gain_cnaBRCA30_(CRNKL1,FOXA2) 225 Genentech Cpd 10 AURKA, AURKB 5 44 2.32630161961136 NA 3.34977339912274 2.98036913413356 0.36940426498918 2.06140160452509 1.57458234905204 0.227786438470953 0.17920053238451 0.234604601792708 0.631577814054439 NA NA NA 0.715478480769188 99.482402686627 a7341 PIK3CA_mut 1194 SB-505124 TGFR1 (ALK5) 16 31 2.30258509299405 NA 4.29854562161163 4.43568474995906 -0.137139128347432 0.929088234346807 0.919638642762793 0.148612092070975 0.147606140383262 0.149122842354075 0.631594895833364 NA NA NA 0.633870079511726 99.482402686627 a7342 gain_cnaBRCA16 281 CH5424802 ALK 16 32 1.63315443905142 NA 3.469793488696 3.62796269472297 -0.15816920602697 1.29452196167161 0.942938668060067 0.147773238233594 0.122183486035823 0.16774071462397 0.631650642452902 NA NA NA 0.667944530823786 99.482402686627 a7343 loss_cnaBRCA20 190 Bleomycin DNA damage 3 45 4.15888308335967 NA 1.33480049525228 2.12797240040123 -0.793171905148943 2.23033431786054 2.77896497016563 0.287653951868812 0.355629153350336 0.285419900453682 0.631802193134836 NA NA NA 0.607476481216054 99.482402686627 a7344 TP53_mut 140 Vinorelbine Microtubules 37 10 -2.74887219562247 NA -3.66035704611802 -3.37581937328874 -0.284537672829274 1.62428944814537 1.77137133739814 0.171951850889168 0.175176704591759 0.160631295551623 0.631819835702222 NA NA NA 0.653932707151895 99.482402686627 a7345 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1170 CCT018159 HSP90 13 30 2.30258509299405 NA 3.20886974723837 3.40087716423128 -0.192007416992906 1.24509498713397 1.17793874399978 0.160275447735742 0.154211059378594 0.163002887858948 0.631885718675808 NA NA NA 0.641645648036084 99.482402686627 a7346 loss_cnaBRCA22_(SYNCRIP,ZNF292) 91 KIN001-135 IKKE 4 10 1.6094379124341 NA 3.617769442863 3.7377059271371 -0.119936484274094 0.360605386823905 0.428696030917621 0.290594600969684 0.332597594646201 0.279770456510574 0.632149431537223 NA NA NA 0.612256471417298 99.482402686627 a7347 NF1_mut 1170 CCT018159 HSP90 5 38 2.30258509299405 NA 3.09995067914048 3.37478600645618 -0.274835327315697 1.60968590728406 1.14464736848823 0.229413659884413 0.170738481384491 0.240104799855242 0.632201139797664 NA NA NA 0.728201080535959 99.482402686627 a7348 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 309 Y-39983 ROCK 9 40 2.99573227355399 NA 5.09293249776813 4.89944182388602 0.193490673882109 0.402761862533981 1.1811820773046 0.17772218620521 0.48040962136971 0.163811047932293 0.632240269428119 NA NA NA 0.405348908176771 99.482402686627 a7349 ARID1A_mut 286 KIN001-236 TIE2 5 44 2.32630161961136 NA 4.38278453669623 4.55798120166048 -0.17519666496425 0.653480851312114 0.780842969432985 0.227285103998255 0.268097626139275 0.224368627012767 0.632326756874732 NA NA NA 0.600461806616792 99.482402686627 a7350 gain_cnaBRCA47_(EGFR) 1143 HG-5-88-01 EGFR, ADCK4 3 23 2.30258509299405 NA 4.2742210177256 4.56797131208185 -0.293750294356253 1.08509715311353 0.978434542210588 0.297389416163955 0.27071335825864 0.300224779158532 0.632447154927131 NA NA NA 0.692165772025896 99.482402686627 a7351 gain_cnaBRCA63 171 AKT inhibitor VIII AKT1, AKT2, AKT3 6 41 0.940007258491471 NA 2.11988907168063 1.85482011106314 0.265068960617489 1.55527026775208 1.2178430696693 0.210404593031888 0.170432731926784 0.217654447620634 0.632590215164442 NA NA NA 0.703221308514765 99.482402686627 a7352 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 274 PXD101, Belinostat HDAC 7 41 2.99573227355399 NA 0.924154604984864 0.628367765157746 0.295786839827119 2.58830176534429 1.26253204351033 0.196758905474474 0.114278344120271 0.234280659526642 0.632710908816934 NA NA NA 0.776180977051728 99.482402686627 a7353 gain_cnaBRCA62 254 AC220 FLT3 10 38 0.0237165266173161 NA 2.34385253894247 2.19215909674334 0.15169344219913 0.505780343462461 0.95788042521616 0.170877560433549 0.299919607710869 0.158363651877423 0.632944077768577 NA NA NA 0.50194039022215 99.482402686627 a7354 loss_cnaBRCA24 231 FMK RSK 3 46 2.99573227355399 2.32630161961136 5.42888783201669 5.59968677554255 -0.170798943525864 0.552616719141879 0.59822067533753 0.28640667448997 0.309073065670337 0.28551160226867 0.632998505451706 NA NA NA 0.650955318268902 99.482402686627 a7355 loss_cnaBRCA24 186 Bexarotene Retinioic acid X family agonist 3 44 2.07944154167984 NA 3.29663587838698 3.62538975203644 -0.32875387364946 1.63961787462998 1.1177809092549 0.286863118324804 0.200506397701752 0.294112979500253 0.633028475905281 NA NA NA 0.763246654343064 99.482402686627 a7356 loss_cnaBRCA36_(FAT1,IRF2) 292 Masitinib KIT 9 39 2.99573227355399 NA 4.16829055475239 3.97387434138378 0.194416213368612 0.851417042418988 1.1397200306876 0.177541514242549 0.228344282158424 0.170582430889908 0.633430586564375 NA NA NA 0.572800579704736 99.482402686627 a7357 loss_cnaBRCA24 1268 XAV 939 TNKS1 (tankyrase-1) 3 44 1.6094379124341 NA 3.40857037234504 3.67868397986463 -0.27011360751959 0.426016697287687 0.961467182941855 0.286094908296873 0.634044649515659 0.280938977753883 0.633936740651844 NA NA NA 0.403002654421078 99.482402686627 a7358 gain_cnaBRCA48 1019 Bosutinib SRC, ABL, TEC 5 40 0.693147180559945 NA 2.47268754847889 2.68633741091387 -0.213649862434981 0.741901905195634 0.95710275724821 0.227488784975752 0.287975891339224 0.223225626315456 0.633950434016737 NA NA NA 0.579985156875944 99.482402686627 a7359 loss_cnaBRCA60 261 TL-1-85 MAP3K7 (TAK1) 3 46 2.32630161961136 NA 3.69827216914583 4.0461021809512 -0.347830011805363 0.463445194840423 1.24089587921685 0.285583014150316 0.750531056698365 0.280305557969041 0.633974077021194 NA NA NA 0.340147665874314 99.482402686627 a7360 loss_cnaBRCA36_(FAT1,IRF2) 274 PXD101, Belinostat HDAC 9 39 2.99573227355399 NA 0.455028576722719 0.721459061945055 -0.266430485222336 1.33521411487012 1.53637462766502 0.177227468260839 0.199541393590085 0.173415051527671 0.634029941199646 NA NA NA 0.608913398302358 99.482402686627 a7361 loss_cnaBRCA42 154 CHIR-99021 GSK3B 3 44 0.940007258491471 NA 3.51911756240978 3.25882226585942 0.260295296550354 0.195802060405959 0.930675766744238 0.285820487829321 1.32937976245337 0.279684188469781 0.634261329876364 NA NA NA 0.174970081833084 99.482402686627 a7362 BRCA2_mut 225 Genentech Cpd 10 AURKA, AURKB 6 43 2.32630161961136 NA 2.72108765506272 3.05950192946777 -0.338414274405051 1.54245352052323 1.63096286152433 0.208668860692553 0.219399981848564 0.207493550214113 0.634289055734088 NA NA NA 0.633267670608506 99.482402686627 a7363 gain_cnaBRCA10_(MDM2,NUP107) 153 Midostaurin KIT 4 43 -0.669430653942629 NA 0.947236378135518 0.581016407472276 0.366219970663241 1.7632080587481 1.43928663206145 0.250301701908721 0.207700939685622 0.254445474935535 0.634379880701278 NA NA NA 0.711025771642528 99.482402686627 a7364 loss_cnaBRCA28_(GPS2) 274 PXD101, Belinostat HDAC 4 44 2.99573227355399 NA 0.326999771330688 0.702821852750884 -0.375822081420196 0.777258266300262 1.54127823416229 0.249992467604981 0.483522784786971 0.243837921726352 0.634420298819039 NA NA NA 0.441187448791811 99.482402686627 a7365 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1230 IOX2 EGLN1 9 38 -2.30258509299405 NA 0.343746677697457 0.227132299454188 0.116614378243269 0.428089502527881 0.696922363400063 0.177436754748933 0.272406535443307 0.167327645613701 0.634513254712137 NA NA NA 0.529261796099861 99.482402686627 a7366 gain_cnaBRCA15 34 Imatinib ABL, KIT, PDGFR 6 8 0.693147180559945 NA 2.70473199543105 2.83190307551187 -0.127171080080826 0.350549660658065 0.558464970445802 0.263381711505615 0.362776217903321 0.227715410653796 0.634559121912988 NA NA NA 0.611709964768667 99.482402686627 a7367 NF1_mut 1527 GDC0941 (rescreen) PI3K 5 40 1.38629436111989 NA 1.21491214742111 0.951373803106428 0.263538344314681 0.808780587566427 1.19277631981128 0.226715386098349 0.325846525455875 0.22094531886446 0.635101048812911 NA NA NA 0.540624991407828 99.482402686627 a7368 MLL3_mut 1261 rTRAIL TR10A (DR4), TR10B (DR5) 3 44 -2.30258509299405 NA 0.137634453649956 -0.159576742262472 0.297211195912427 0.919164089707916 1.04795955222837 0.285074648707769 0.323349442434019 0.283609415344745 0.635143888448107 NA NA NA 0.63762656796732 99.482402686627 a7369 gain_cnaBRCA9_(KRAS) 346 THZ-2-102-1 CDK7 4 44 0.916290731874155 2.99573227355399 -0.75033215719452 -1.38832359154101 0.637991434346485 2.06652560936483 2.58832695329446 0.249454762029445 0.308726604429827 0.24648796147428 0.635147498224355 NA NA NA 0.595130183807298 99.482402686627 a7370 gain_cnaBRCA13_(FGFR1,WHSC1L1) 228 KIN001-102 AKT1 11 38 2.32630161961136 NA 2.12284228713634 1.89184765906647 0.230994628069869 1.155972029306 1.47573898124893 0.163388701596616 0.199827177659782 0.156528106260618 0.635422227228905 NA NA NA 0.590776599509869 99.482402686627 a7371 gain_cnaBRCA48 222 BX-912 PDPK1 (PDK1) 5 44 2.32630161961136 NA 4.19101599118962 3.84886768767438 0.342148303515247 1.37834767130504 1.53175427762517 0.225201048426151 0.248230769810999 0.223370228837039 0.6354442919207 NA NA NA 0.62460929927969 99.482402686627 a7372 loss_cnaBRCA24 1192 GSK269962A ROCK1, ROCK2 3 43 1.6094379124341 NA 3.06000688741219 2.64059038816027 0.419416499251914 0.230123637530533 1.50525183052019 0.285033886976643 1.82257026593484 0.278635435445357 0.635494615742662 NA NA NA 0.127878319774701 99.482402686627 a7373 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1375 Temozolomide DNA akylating agent 9 37 3.40119738166216 NA 6.00023978387311 5.8757739182244 0.124465865648714 0.839856923091176 0.667218411538188 0.177359085313411 0.148198892247748 0.186544411089877 0.635584497546748 NA NA NA 0.687166833808305 99.482402686627 a7374 loss_cnaBRCA34 268 YM155 BIRC5 (Survivin) 5 44 1.63315443905142 NA -3.92016267570022 -3.55869337996278 -0.361469295737439 1.8149009475916 1.58546012391372 0.225037367143904 0.199167506203087 0.227990152691542 0.635689426160783 NA NA NA 0.68800453262023 99.482402686627 a7375 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1494 SN-38 TOP1 18 30 -2.99573227355399 NA -3.4541085214278 -3.21359650302106 -0.240512018406733 1.65431231307455 1.71388215991545 0.142137213422431 0.145384892868106 0.1403317124315 0.635802381004001 NA NA NA 0.633304218475456 99.482402686627 a7376 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1009 ATRA Retinoic acid and retinoid X receptor agonist 8 37 2.30258509299405 NA 3.92805449300896 4.1444392777646 -0.216384784755641 0.876856826964143 1.21159506108874 0.185948223179312 0.246773222379769 0.178594970964306 0.635844821888152 NA NA NA 0.566730210784046 99.482402686627 a7377 loss_cnaBRCA42 226 GSK1070916 AURKB 3 46 0.940007258491471 2.32630161961136 2.92582707883601 2.36991209814664 0.55591498068937 0.581835742889377 1.99685837473536 0.283978827200479 0.955450034624403 0.278394796407654 0.63587601580305 NA NA NA 0.259035793319827 99.482402686627 a7378 gain_cnaBRCA14_(RAD21) 287 KIN001-244 PDPK1 (PDK1) 21 28 2.99573227355399 NA 3.40364807720509 3.53394951534626 -0.130301438141161 1.15496065437702 0.758029067765643 0.137523659412157 0.112818941188473 0.171895041604719 0.635999670874745 NA NA NA 0.65607671137528 99.482402686627 a7379 TP53_mut 88 MS-275 HDAC 9 5 1.6094379124341 NA 0.964005950631269 1.45447183209795 -0.490465881466678 1.65329758846287 2.0928280999598 0.270722117765553 0.296659164623038 0.234355550499393 0.636160000993318 NA NA NA 0.665542839801862 99.482402686627 a7380 loss_cnaBRCA20 175 PAC-1 CASP3 agonist 3 45 0.940007258491471 NA 2.72835749441782 2.3795834209528 0.348774073465022 1.37149723590911 1.22202433597215 0.283809679599086 0.254301696228964 0.285406814904028 0.63635334381137 NA NA NA 0.70589895694165 99.482402686627 a7381 gain_cnaBRCA62 3 Rapamycin MTOR 5 9 -2.30258509299405 NA -2.27214913597277 -3.00339380037291 0.731244664400144 1.20692073937088 3.19837187477789 0.270548073482361 0.605876293733517 0.228630282227868 0.636374912092158 NA NA NA 0.55284271192694 99.482402686627 a7382 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1013 Nilotinib ABL 6 34 0.693147180559945 NA 3.37568640619785 3.17241696644222 0.203269439755635 0.399788240710388 1.02224740032209 0.210948344401729 0.508442768087534 0.198845641174131 0.63652557732443 NA NA NA 0.406491419443687 99.482402686627 a7383 gain_cnaBRCA13_(FGFR1,WHSC1L1) 34 Imatinib ABL, KIT, PDGFR 4 10 0.693147180559945 NA 2.67848147023896 2.81696906957255 -0.138487599333589 0.446548251904467 0.494418071189346 0.286785737188751 0.310129081779984 0.28010221997034 0.636577313076279 NA NA NA 0.629053303219776 99.482402686627 a7384 loss_cnaBRCA29_(MAP2K4) 1054 PD-0332991 CDK4, CDK6 4 38 1.38629436111989 0.693147180559945 3.21668548396019 2.84776992298472 0.36891556097547 0.845046401425811 1.5137511439778 0.250255085863787 0.436562489767443 0.243709517540672 0.636607424014742 NA NA NA 0.482378934085613 99.482402686627 a7385 gain_cnaBRCA9_(KRAS) 257 NPK76-II-72-1 PLK3 4 45 2.32630161961136 NA 3.11609225871071 3.51121523381137 -0.395122975100664 1.04920814409871 1.62310699112643 0.248089062349856 0.376591601316707 0.243436185821891 0.63663686557947 NA NA NA 0.528355685108451 99.482402686627 a7386 gain_cnaBRCA13_(FGFR1,WHSC1L1) 253 XMD14-99 EPHB3, CAMK1 11 37 2.32630161961136 NA 5.03089321885688 4.90402872765614 0.126864491200743 0.750819725762761 0.784192520836023 0.163262261692004 0.168967978394361 0.161777226675783 0.636749182093711 NA NA NA 0.632481958670307 99.482402686627 a7387 gain_cnaBRCA15 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 21 24 -0.669430653942629 NA -3.30094601499116 -3.64828128105311 0.347335266061951 2.71560463915903 2.18122864810216 0.142097135390224 0.127903473522388 0.159238356952702 0.636803467659486 NA NA NA 0.642009982453541 99.482402686627 a7388 gain_cnaBRCA9_(KRAS) 1067 CCT007093 PPM1D 4 42 1.88706964903238 NA 4.31071132245362 4.06420050023508 0.246510822218538 0.552909698430529 1.01558275050222 0.248768841630027 0.445842825543259 0.242728445413863 0.636843870856335 NA NA NA 0.471710779650466 99.482402686627 a7389 loss_cnaBRCA28_(GPS2) 1377 Afatinib (rescreen) ERBB2, EGFR 4 43 2.30258509299405 NA 3.2888969686122 2.79238367989949 0.496513288712712 2.502300874282 1.95757381999096 0.24844129799847 0.198422697212692 0.253637070358351 0.636894439363316 NA NA NA 0.722716287492189 99.482402686627 a7390 BRCA1_mut 208 SB-715992 KIF11 4 45 -2.05572501506252 NA -1.63070512137648 -1.20516098687286 -0.42554413450362 2.43548654395172 1.65627581938648 0.247897503729904 0.174726538958064 0.256928302353197 0.636896575313536 NA NA NA 0.752945822628305 99.482402686627 a7391 ARID1A_mut 253 XMD14-99 EPHB3, CAMK1 5 43 2.32630161961136 NA 4.77692864321409 4.95126151429377 -0.174332871079688 0.431429117687665 0.802252798321112 0.224348084203527 0.40408230212662 0.217304160788865 0.63716813083377 NA NA NA 0.468021983028578 99.482402686627 a7392 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1025 SB 216763 GSK3A, GSK3B 7 32 2.30258509299405 NA 5.01804850326335 4.86096726480274 0.157081238460611 1.00704215172868 0.742877735962842 0.198403628894939 0.15598278402842 0.211449651613288 0.637233100774076 NA NA NA 0.707298904479578 99.482402686627 a7393 loss_cnaBRCA28_(GPS2) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 4 39 1.6094379124341 NA 3.28841945408543 2.91077707366408 0.377642380421357 1.03846343279207 1.54532221733623 0.24943357824582 0.363654962222413 0.244377759010236 0.637238546013971 NA NA NA 0.543540824280683 99.482402686627 a7394 loss_cnaBRCA7_(FAS,PTEN) 275 I-BET BRD2, BRD3, BRD4 4 45 2.99573227355399 NA 4.34963040937647 4.0113242282167 0.338306181159772 1.6786681413417 1.34214406413748 0.247643171951236 0.201532496404785 0.252063984932335 0.637241462267819 NA NA NA 0.718633433645335 99.482402686627 a7395 PIK3CA_mut 1218 JQ1 BRD2, BRD3, BRD4 16 30 0 NA 2.52563944561335 2.42189783275077 0.103741612862583 0.69478549775895 0.711470711634678 0.146978834690958 0.149314591621737 0.145812907216133 0.637288805307552 NA NA NA 0.635748781473111 99.482402686627 a7396 gain_cnaBRCA30_(CRNKL1,FOXA2) 1032 Afatinib ERBB2, EGFR 5 40 -0.693147180559945 NA -0.0782227015602507 0.336558498389564 -0.414781199949814 2.66509894808193 1.73548015836215 0.225197307752587 0.155634446611572 0.239000830952318 0.637362204220809 NA NA NA 0.749968576959068 99.482402686627 a7397 gain_cnaBRCA10_(MDM2,NUP107) 173 FH535 unknown 4 44 3.46573590279973 NA 1.86518068255399 1.54643601452848 0.318744668025516 1.23059980965624 1.29054062473574 0.247719410921861 0.259015697487029 0.246985381100099 0.637496885726736 NA NA NA 0.649754035807401 99.482402686627 a7398 loss_cnaBRCA36_(FAT1,IRF2) 1023 GW 441756 NTRK1 8 37 0.693147180559945 NA 2.55831509729823 2.31625364356422 0.242061453734008 1.16867734152426 1.33435774732565 0.18494682124128 0.207124280700349 0.181406713618707 0.637660047830073 NA NA NA 0.614808020508751 99.482402686627 a7399 loss_cnaBRCA17 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 9 38 2.99573227355399 NA 4.05158644299334 3.7993645506932 0.252221892300134 1.52828848167878 1.41411919132042 0.175754593913382 0.165035525245258 0.178359712426096 0.637720362733959 NA NA NA 0.660083741320844 99.482402686627 a7400 loss_cnaBRCA23 203 BMS-345541 IKBKB 3 46 2.77258872223978 NA 3.26378323117251 3.54984620506338 -0.286062973890871 0.671060104584255 1.02583313459371 0.282316632582587 0.426285174661214 0.278859167484553 0.637849346827206 NA NA NA 0.546844258420361 99.482402686627 a7401 gain_cnaBRCA58_(CCND1) 1529 MLN4924 NEDD8-activating enzyme 7 30 0 NA 0.64569046570346 0.304704393900526 0.340986071802933 0.865278073826169 1.83779618185696 0.199313517713249 0.39407686629008 0.18554074449017 0.637852060073254 NA NA NA 0.474975268673521 99.482402686627 a7402 gain_cnaBRCA10_(MDM2,NUP107) 200 LAQ824 HDAC 4 44 0.0237165266173161 NA -2.36283365483518 -2.71370684216224 0.350873187327066 2.06506604354807 1.3614431430861 0.247439804384726 0.169908942342695 0.257721513460865 0.637875781221058 NA NA NA 0.759318939266917 99.482402686627 a7403 loss_cnaBRCA17 211 TL-2-105 CRAF 11 38 2.32630161961136 1.63315443905142 4.04509182689652 3.86774007877901 0.17735174811751 0.831492948200832 1.15448976341756 0.162145059635258 0.21329314758623 0.153619160374803 0.637991532360266 NA NA NA 0.576529593062478 99.482402686627 a7404 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 219 AT-7519 CDK9 7 42 2.32630161961136 NA 1.37033667620221 1.72227780789364 -0.351941131691434 1.70165010663761 1.83804734411715 0.193246427050647 0.206823441739651 0.191475553019815 0.638151094686714 NA NA NA 0.629280606267862 99.482402686627 a7405 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 287 KIN001-244 PDPK1 (PDK1) 9 40 2.99573227355399 NA 3.61306394521003 3.4477405136028 0.165323431607238 0.66990297923341 0.99493430164659 0.174480746833674 0.246787126990273 0.166165174256865 0.638449167207189 NA NA NA 0.55298529426589 99.482402686627 a7406 loss_cnaBRCA60 253 XMD14-99 EPHB3, CAMK1 3 45 2.32630161961136 NA 5.13846304380656 4.9194110933174 0.219051950489156 0.048579667659819 0.794477842531401 0.281890870973312 4.5091282225946 0.275718136822045 0.638630309601253 NA NA NA 0.0784685824465375 99.482402686627 a7407 gain_cnaBRCA27_(CLTC,PPM1D) 294 MPS-1-IN-1 MPS1 9 40 2.99573227355399 NA 4.92406396560367 4.71881979385805 0.205244171745621 1.12950688661667 1.18804700982284 0.174188438368799 0.181711306214706 0.172757618215988 0.639010374208082 NA NA NA 0.634261297930722 99.482402686627 a7408 loss_cnaBRCA28_(GPS2) 279 BIX02189 MAP2K5 (MEK5) 4 45 2.99573227355399 NA 5.23195508797337 5.00916946290719 0.222785625066181 0.79986165029925 0.911244503673014 0.246295834183151 0.278530199544923 0.244485013811534 0.639069873019485 NA NA NA 0.627684808976127 99.482402686627 a7409 gain_cnaBRCA31 276 CAY10603 HDAC6 16 33 2.99573227355399 NA 1.07902930929853 1.22233268410532 -0.14330337480679 1.06620088863951 0.962540522450924 0.14376406425742 0.134405604360026 0.148880355127175 0.639166905099791 NA NA NA 0.652604149420573 99.482402686627 a7410 POLR2B_mut 223 ZSTK474 PI3K 3 46 1.63315443905142 2.32630161961136 0.528350032604591 0.937380652336528 -0.409030619731937 1.05161367844291 1.47034758817622 0.281123386346153 0.388955210565135 0.278186343842199 0.639267586076614 NA NA NA 0.578236220045683 99.482402686627 a7411 ASH1L_mut 173 FH535 unknown 3 45 3.46573590279973 NA 1.23364994817591 1.59562127833203 -0.361971330156113 0.208588192798809 1.31491809983474 0.281306528614448 1.73533949980212 0.275280513821817 0.639324423971196 NA NA NA 0.131162481650213 99.482402686627 a7412 PIK3CA_mut 1495 AZD-2281 PARP1, PARP2 16 29 2.30258509299405 NA 3.89107861539508 4.05806381091959 -0.166985195524516 1.21108552672973 1.09383815821647 0.14697932660149 0.13788059706685 0.152659874104949 0.639338733721734 NA NA NA 0.650428583802761 99.482402686627 a7413 TP53_mut 256 JW-7-24-1 LCK 37 11 2.32630161961136 NA 1.79417236468927 1.98354006192741 -0.189367697238139 1.19596766030165 1.07044155155637 0.161876844827318 0.158338476468817 0.176906153318513 0.639605049811271 NA NA NA 0.622355006120778 99.482402686627 a7414 gain_cnaBRCA8_(CHD4,WNK1) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 43 1.38629436111989 NA 2.4668447580386 2.88594164996416 -0.41909689192556 0.536084098478781 1.51985420831884 0.281404822899324 0.781774525890267 0.275748087962421 0.639793477983348 NA NA NA 0.329840624963186 99.482402686627 a7415 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1262 UNC1215 LMBL3 8 38 0 NA 2.66713802586769 2.77654815910426 -0.109410133236573 0.27503882476269 0.640166002761313 0.183204698358416 0.397798868326952 0.170909002922116 0.639987902656937 NA NA NA 0.448869732334998 99.482402686627 a7416 PIK3CA_mut 185 OSI-906 IGF1R 17 31 0.940007258491471 NA 2.99751997388535 2.83644116930934 0.161078804576007 1.12633401126707 1.13765981614811 0.142078223590811 0.14301157823939 0.141587847517887 0.64002715954414 NA NA NA 0.639874417564908 99.482402686627 a7417 PIK3CA_mut 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 17 31 2.77258872223978 NA -0.566356941927465 -0.365330247131568 -0.201026694795896 1.60359760510796 1.30354087067784 0.142053978147931 0.12535981230925 0.154215874099415 0.640084103690709 NA NA NA 0.661321836003429 99.482402686627 a7418 ASH1L_mut 1373 Dabrafenib BRAF 3 43 2.30258509299405 NA 3.78273781636679 4.24471829305836 -0.461980476691572 1.84318127456161 1.63384149093072 0.281021073400667 0.250642995926405 0.282757219262687 0.640248789847589 NA NA NA 0.709909480504969 99.482402686627 a7419 NF1_mut 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 4 39 0.693147180559945 NA 3.12390772287329 2.8863172546076 0.237590468265695 0.935883678679537 0.963313141271056 0.247146988410832 0.253867519733775 0.246638873785323 0.640319556692369 NA NA NA 0.656892008207323 99.482402686627 a7420 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 268 YM155 BIRC5 (Survivin) 9 40 1.63315443905142 NA -3.82307585310023 -3.54439098547404 -0.278684867626189 1.48755811366928 1.62967093855352 0.173487384845238 0.187343852361353 0.171006833976893 0.640357205666567 NA NA NA 0.626497626120081 99.482402686627 a7421 CDH1_mut 178 BAY 61-3606 SYK 4 44 2.07944154167984 NA 3.45922524869329 3.06270987374827 0.396515374945025 1.70697335074551 1.60822209299578 0.245543697205437 0.232291485260652 0.246555109939076 0.640447775226235 NA NA NA 0.681167084707543 99.482402686627 a7422 loss_cnaBRCA28_(GPS2) 219 AT-7519 CDK9 4 45 2.32630161961136 NA 1.26176235710949 1.7084661163669 -0.446703759257414 1.26216565896338 1.85325136486799 0.245271398889581 0.35391848612352 0.241037868756262 0.640461605136819 NA NA NA 0.550091555136153 99.482402686627 a7423 gain_cnaBRCA15 1011 ABT-263 BCL2, BCL2L1, BCL2L2 20 23 0.693147180559945 NA 1.81124619681744 1.56951295628514 0.241733240532302 1.26918649761425 1.96823695572215 0.143817699115267 0.190463136021931 0.122817143448874 0.640570002863484 NA NA NA 0.630838958578895 99.482402686627 a7424 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1371 PLX4720 (rescreen) BRAF 6 41 2.30258509299405 NA 4.87944343850825 4.6819332811348 0.197510157373448 1.01914827620864 0.954006740832076 0.205426757185002 0.193799236072116 0.20703224507741 0.640641899336932 NA NA NA 0.669771721880401 99.482402686627 a7425 PIK3CA_mut 193 GW-2580 CSF1R (cFMS) 16 32 2.99573227355399 NA 5.53528562584946 5.4274404883671 0.107845137482364 0.941739513318702 0.636179233161646 0.14386430088675 0.114516950767327 0.169520053250405 0.640675769369309 NA NA NA 0.683351452921192 99.482402686627 a7426 gain_cnaBRCA15 1 Erlotinib EGFR 6 6 0.693147180559945 NA 3.00760425097528 2.84554093815125 0.162063312824032 0.312437487180685 0.763553736361081 0.277807323594301 0.518706363587894 0.212248732612309 0.640746202464315 NA NA NA 0.645866276799487 99.482402686627 a7427 loss_cnaBRCA36_(FAT1,IRF2) 226 GSK1070916 AURKB 9 40 0.940007258491471 2.32630161961136 2.12713664469715 2.46623019872447 -0.339093554027316 1.93663155179072 1.96203231349138 0.17320733621347 0.175094510731157 0.172827711192946 0.640895564401218 NA NA NA 0.644394647617772 99.482402686627 a7428 loss_cnaBRCA42 153 Midostaurin KIT 3 44 -0.669430653942629 NA 0.228404707829658 0.63835083887184 -0.409946131042182 1.23749041751074 1.47291595066857 0.28016000793721 0.331272166023561 0.278322826809028 0.64097278709595 NA NA NA 0.630421334308709 99.482402686627 a7429 BRCA1_mut 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 38 1.38629436111989 0.693147180559945 3.66816775428088 3.40872053048858 0.259447223792295 1.17157320540176 1.03997882967081 0.246993698581414 0.221451995142997 0.249473562720906 0.640995474962444 NA NA NA 0.695129745295009 99.482402686627 a7430 ARID1A_mut 1013 Nilotinib ABL 4 36 0.693147180559945 NA 2.98807612950595 3.22677752161663 -0.238701392110678 0.921310351700355 0.967219559305622 0.247699145640507 0.259089015628811 0.246791320351343 0.641058175194864 NA NA NA 0.651821690920743 99.482402686627 a7431 loss_cnaBRCA38 136 Mitomycin C DNA crosslinker 4 44 2.77258872223978 NA -0.468211338352887 -0.103950190022663 -0.364261148330224 0.383973327337487 1.53389520883711 0.245083789742754 0.94866263460551 0.237474598154838 0.641072295800175 NA NA NA 0.243436534960279 99.482402686627 a7432 loss_cnaBRCA17 196 Phenformin AAPK1 (AMPK) agonist 10 38 8.29404964010203 NA 6.96174707120688 7.26524098216717 -0.303493910960292 1.54787972676396 1.88141442999633 0.166665973398412 0.196070731926171 0.161311567574659 0.641326827617779 NA NA NA 0.605696094797032 99.482402686627 a7433 loss_cnaBRCA7_(FAS,PTEN) 1030 KU-55933 ATM 4 38 2.30258509299405 NA 4.42939921207392 4.20049937009778 0.228899841976141 0.738156020828403 0.941487471322523 0.246716568539849 0.310096829826377 0.243125744046919 0.641368944917608 NA NA NA 0.596529759775904 99.482402686627 a7434 loss_cnaBRCA22_(SYNCRIP,ZNF292) 185 OSI-906 IGF1R 18 30 0.940007258491471 NA 2.99249003566903 2.83408983875326 0.158400196915766 1.19346380673733 1.09724889758314 0.139712507942358 0.132723083868625 0.144361226759642 0.641561604192693 NA NA NA 0.649425932630869 99.482402686627 a7435 gain_cnaBRCA16 71 Pyrimethamine Dihydrofolate reductase (DHFR) 3 11 2.99573227355399 NA 4.31928693268068 4.63781172709788 -0.3185247944172 1.48904482836078 0.902943805854328 0.311001635824132 0.213912159224816 0.352762588714838 0.641599046123751 NA NA NA 0.752419713352091 99.482402686627 a7436 gain_cnaBRCA12_(TERT) 1050 ZM-447439 AURKB 8 31 1.38629436111989 0.693147180559945 3.08392406516498 2.83734344062852 0.246580624536459 1.39201102213805 1.30952088524539 0.186025449147116 0.17713985062972 0.188298351950494 0.641750303611159 NA NA NA 0.660478746168155 99.482402686627 a7437 loss_cnaBRCA20 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 3 40 -1.38629436111989 0.693147180559945 -1.97050215554384 -2.23926182479001 0.26875966924617 0.985479638394826 0.956554010436388 0.280546762970669 0.272719657286813 0.280966538547634 0.641792141907228 NA NA NA 0.687689603386369 99.482402686627 a7438 loss_cnaBRCA60 238 CAL-101 PI3Kdelta 3 46 2.99573227355399 2.32630161961136 4.96771645511344 4.70274124753976 0.264975207573685 0.467739176808851 0.966144892668393 0.278840170662547 0.566502060788403 0.274260320149135 0.641985108622011 NA NA NA 0.444704114511851 99.482402686627 a7439 BRCA2_mut 255 CP724714 ERBB2 6 42 2.32630161961136 NA 3.50344632426513 3.84583416535594 -0.342387841090805 2.12630939607474 1.61396934315042 0.204135626633139 0.161024468839233 0.212140238316098 0.64218365484867 NA NA NA 0.717962864798849 99.482402686627 a7440 MLL3_mut 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 3 43 0 NA 1.19386566606404 0.615495341655676 0.578370324408359 1.71568732153284 2.08622237359978 0.279295489427105 0.337107069073419 0.277233305388428 0.642297893949788 NA NA NA 0.625215267407797 99.482402686627 a7441 ASH1L_mut 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 3 40 1.6094379124341 NA 2.55147289503516 2.97548912510338 -0.424016230068219 1.50553000657321 1.51456532661548 0.280040285696443 0.28163917571682 0.279959023633366 0.642392026641059 NA NA NA 0.678799854564943 99.482402686627 a7442 gain_cnaBRCA15 206 Ruxolitinib JAK1, JAK2, TYK2 22 27 1.65632149833295 0.0237165266173161 4.41883129010398 4.33068421414544 0.0881470759585437 0.592061220315505 0.704675810993356 0.134217199837996 0.148881691510839 0.125088834586625 0.642438814362827 NA NA NA 0.636440064965721 99.482402686627 a7443 CDH1_mut 1170 CCT018159 HSP90 4 39 2.30258509299405 NA 3.60968310355016 3.31545869812401 0.294224405426152 0.809126632314236 1.22364903531418 0.245557236849882 0.363632086345522 0.240448361364177 0.642465428841737 NA NA NA 0.544373887228683 99.482402686627 a7444 gain_cnaBRCA47_(EGFR) 1502 Bicalutamide ANDR (androgen receptor) 6 39 2.30258509299405 NA 4.66252047711914 4.5422696953843 0.120250781734838 0.454158260964652 0.602025636331879 0.204943989409473 0.264777263941914 0.199743622991742 0.642613376020631 NA NA NA 0.580832268239723 99.482402686627 a7445 loss_cnaBRCA24 266 Zibotentan, ZD4054 Endothelin A Receptor 3 46 2.99573227355399 NA 5.87135319986833 5.73360587480525 0.13774732506308 0.369567948763016 0.499807661649142 0.278297574827464 0.372725301325872 0.27560066728184 0.64263164575387 NA NA NA 0.592568869955165 99.482402686627 a7446 gain_cnaBRCA9_(KRAS) 175 PAC-1 CASP3 agonist 4 44 0.940007258491471 NA 2.67613616121988 2.37640413139204 0.299732029827839 1.12340028262467 1.23604535341906 0.243880139838575 0.266807864003342 0.242492744298372 0.642708005637381 NA NA NA 0.641247792052879 99.482402686627 a7447 ARID1A_mut 1373 Dabrafenib BRAF 5 41 2.30258509299405 NA 3.89035078289613 4.25413039356413 -0.363779610668006 1.25436586541509 1.67799031870809 0.221277683161314 0.290010770141315 0.216794820930841 0.64271359247288 NA NA NA 0.578590082729844 99.482402686627 a7448 loss_cnaBRCA18 1008 Methotrexate Dihydrofolate reductase (DHFR) 14 31 -1.6094379124341 NA 0.796194616004777 0.631371894390868 0.164822721613908 0.933599810049199 1.15887487834867 0.150431785669709 0.176545367554458 0.142226503217303 0.642734494096791 NA NA NA 0.615577080400159 99.482402686627 a7449 loss_cnaBRCA7_(FAS,PTEN) 302 PI-103 PI3Ka, PRKDC (DNAPK) 4 44 2.32630161961136 NA 0.711852587278023 1.16630412050717 -0.454451533229144 1.23107239938652 1.89992443121202 0.243852189317447 0.369150939827432 0.23919453098418 0.642746010533667 NA NA NA 0.536569163731893 99.482402686627 a7450 loss_cnaBRCA60 345 KIN001-270 CDK9 3 46 2.99573227355399 NA 4.92640323015068 5.11940332022183 -0.193000090071148 0.139406234188604 0.708464182633793 0.278169125807288 1.38444375313974 0.272420391604907 0.642784741796822 NA NA NA 0.167434732789699 99.482402686627 a7451 loss_cnaBRCA23 308 XL-880 MET 3 46 1.63315443905142 NA 2.26875195453183 1.82027119918458 0.448480755347243 0.472245342815866 1.64494990572613 0.278124873501891 0.949677455097977 0.272640980607413 0.642837488939598 NA NA NA 0.263366675711682 99.482402686627 a7452 loss_cnaBRCA22_(SYNCRIP,ZNF292) 134 Etoposide TOP2 17 30 2.77258872223978 NA 2.67338709343893 2.36587330555475 0.307513787884176 2.11269405795285 2.20183866403716 0.141674711919791 0.145555286022885 0.139662270858818 0.642973315534902 NA NA NA 0.639774403644118 99.482402686627 a7453 loss_cnaBRCA28_(GPS2) 1192 GSK269962A ROCK1, ROCK2 4 42 1.6094379124341 NA 2.33984183292684 2.69919142908145 -0.359349596154607 0.989506728320344 1.50083824172368 0.24418483519845 0.3631603362259 0.239432595841842 0.643050308135894 NA NA NA 0.543186867386672 99.482402686627 a7454 ASH1L_mut 1042 BIRB 0796 p38, JNK2 3 40 2.30258509299405 NA 4.60814725328964 4.3484791772076 0.259668076082037 0.176502351461786 0.951902643522899 0.279449368873976 1.47118762969148 0.272788480890263 0.643092229600926 NA NA NA 0.172028445268655 99.482402686627 a7455 loss_cnaBRCA29_(MAP2K4) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 7 41 2.77258872223978 NA -0.667029597120869 -0.397173133999986 -0.269856463120882 1.2439146711504 1.43914293478435 0.190683449983612 0.216941297807279 0.187511925743026 0.643226001982883 NA NA NA 0.617075008639961 99.482402686627 a7456 ARID1A_mut 1375 Temozolomide DNA akylating agent 5 41 3.40119738166216 NA 5.76192611779517 5.91697957171183 -0.155053453916654 0.674199787479349 0.704560067088749 0.220919713918393 0.229981463649458 0.220071305711856 0.643250072963999 NA NA NA 0.648955413649652 99.482402686627 a7457 gain_cnaBRCA9_(KRAS) 1049 PD-173074 FGFR1, FGFR3 4 39 0.693147180559945 NA 3.19310364981122 2.91157530683132 0.281528342979902 0.814777727542872 1.17178040645157 0.24492987477142 0.345527784404353 0.240256912839528 0.643313105850197 NA NA NA 0.561381860143461 99.482402686627 a7458 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 268 YM155 BIRC5 (Survivin) 6 43 1.63315443905142 NA -3.88191181274595 -3.55562444698576 -0.326287365760189 1.59066476425938 1.60830336342223 0.203112567750529 0.205126418269602 0.202876753963815 0.64332020805094 NA NA NA 0.653652429227051 99.482402686627 a7459 gain_cnaBRCA15 1046 681640 WEE1, CHEK1 19 17 0.693147180559945 NA 2.55473374316996 2.72215733467087 -0.167423591500912 1.18852053392731 0.928232446839547 0.155899569964656 0.140867226708892 0.180368174018218 0.643495574878982 NA NA NA 0.638941735095342 99.482402686627 a7460 gain_cnaBRCA58_(CCND1) 303 PIK-93 PI4K, PI3K 10 39 2.99573227355399 NA 2.60376154184865 2.83967224013398 -0.235910698285333 1.07850195073709 1.50029515662242 0.165065414586304 0.218739241152139 0.157242858009642 0.643593288695472 NA NA NA 0.578337759568419 99.482402686627 a7461 BRCA2_mut 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 37 1.38629436111989 0.693147180559945 3.2278901333605 3.46120541915911 -0.23331528579861 1.30964671634827 1.01760141075991 0.222106460822135 0.178151315836664 0.229279640664393 0.643639279867871 NA NA NA 0.718480438030929 99.482402686627 a7462 loss_cnaBRCA34 184 BMS-754807 IGF1R 5 43 0.940007258491471 NA 1.29440202133167 1.66552790041804 -0.371125879086367 0.718667334614707 1.7519026476065 0.219944426450005 0.516408442698089 0.211841610944198 0.643776072421374 NA NA NA 0.393649354044242 99.482402686627 a7463 loss_cnaBRCA42 286 KIN001-236 TIE2 3 46 2.32630161961136 NA 4.74079290524421 4.52701558349586 0.21377732174835 0.361434148955009 0.784201753407165 0.277291153457893 0.591469628330446 0.27260500352051 0.643831600111619 NA NA NA 0.429055880727894 99.482402686627 a7464 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1161 ZG-10 IRAK1 13 13 2.30258509299405 NA 1.84545720996147 2.10536398371892 -0.259906773757449 0.972925629936548 1.75011993840201 0.183563895836617 0.267139404863247 0.148507978255915 0.644008245577169 NA NA NA 0.645174320473371 99.482402686627 a7465 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1058 GDC0941 PI3K (class 1) 8 35 1.38629436111989 0.693147180559945 1.1389991959411 1.39331762636929 -0.254318430428185 1.07996445570645 1.45100156618361 0.182351661050804 0.235487778402693 0.175270955149337 0.644162400737887 NA NA NA 0.584386968796344 99.482402686627 a7466 loss_cnaBRCA34 197 Bryostatin 1 PRKC 5 43 -4.8283137373023 NA -2.61563897645192 -2.82903240525785 0.21339342880593 0.590677063434106 1.00020524835528 0.219659938524542 0.361269197698812 0.213349639143395 0.644203972474277 NA NA NA 0.506651228273874 99.482402686627 a7467 gain_cnaBRCA12_(TERT) 299 OSI-027 MTORC1/2 9 39 2.99573227355399 NA 1.54754364311456 1.20468323759565 0.342860405518907 1.76052046796014 2.04126527722987 0.17183576176332 0.194749457196694 0.167964648859452 0.64435838210555 NA NA NA 0.61802840039464 99.482402686627 a7468 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1039 SL 0101-1 RSK, AURKB, PIM3 6 37 2.30258509299405 NA 4.47801288230786 4.67652816621225 -0.19851528390439 1.35748921750539 0.903046857036607 0.204668844846619 0.146237098125313 0.219828331561695 0.644360532226921 NA NA NA 0.741667166004455 99.482402686627 a7469 gain_cnaBRCA9_(KRAS) 1018 ABT-888 PARP1, PARP2 4 41 1.6094379124341 NA 4.25484886184156 4.41753739496636 -0.162688533124795 0.49446738733606 0.679328849759444 0.243511638701584 0.329017721474572 0.239484210309049 0.64436713474035 NA NA NA 0.576556124300213 99.482402686627 a7470 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 202 GSK-1904529A IGF1R 15 33 0.0237165266173161 NA 2.1063959724463 2.22752826692826 -0.121132294481955 0.885215064943168 0.815322836632363 0.144685281659645 0.136839395621596 0.148569730957474 0.644388924026272 NA NA NA 0.656386227494632 99.482402686627 a7471 gain_cnaBRCA63 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 40 1.38629436111989 NA 2.5951231738768 2.89813215448285 -0.303008980606046 3.14960372551976 1.10947516300135 0.203442879517646 0.0962054299564439 0.273110197245286 0.644440400017934 NA NA NA 0.824315339119993 99.482402686627 a7472 loss_cnaBRCA17 1248 FK866 NAMPT 9 35 0 NA -0.273554960424429 -0.747687532922542 0.474132572498113 2.23381172330978 2.83349315939997 0.173710245079454 0.212252701313432 0.167331468906216 0.644484366900426 NA NA NA 0.599942249977766 99.482402686627 a7473 loss_cnaBRCA57 1003 Camptothecin TOP1 5 40 -2.30258509299405 NA -2.21632734757801 -2.56840070608582 0.352073358507806 1.07834577372245 1.64132697786502 0.220411033053291 0.326493938296292 0.214505313844149 0.64451411806514 NA NA NA 0.541991803687338 99.482402686627 a7474 loss_cnaBRCA38 176 IPA-3 PAK1, PAK2, PAK3 3 44 3.46573590279973 NA 4.89059060883209 4.46999278008354 0.420597828748546 0.755420914138089 1.54382732717737 0.277163140716416 0.556772814833218 0.272438388247433 0.644538449334795 NA NA NA 0.452355733756014 99.482402686627 a7475 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 38 1.6094379124341 NA 2.88243507963817 2.52588170269016 0.356553376948015 1.72435306712248 1.60026498114917 0.221078410871948 0.206775157446738 0.222808960483513 0.64459244880234 NA NA NA 0.679699309359521 99.482402686627 a7476 gain_cnaBRCA48 172 Embelin XIAP 5 43 3.46573590279973 NA 2.80185457303674 3.0152956224431 -0.213441049406359 1.07710067418228 0.962352348922892 0.21939366130095 0.198162580826905 0.221790958005404 0.644604592073009 NA NA NA 0.690081049041424 99.482402686627 a7477 loss_cnaBRCA18 89 Parthenolide NFKB1 6 8 1.6094379124341 NA 3.45941219290502 3.09270572485942 0.366706468045598 1.05867288919509 1.65263533016157 0.255484275787675 0.346383166876413 0.221891945157524 0.644655665654904 NA NA NA 0.623146145465191 99.482402686627 a7478 gain_cnaBRCA48 171 AKT inhibitor VIII AKT1, AKT2, AKT3 5 42 0.940007258491471 NA 2.13599388773383 1.8592140367858 0.276779850948035 1.41047272406812 1.24437984833306 0.219661225081372 0.1962319768579 0.222423925715932 0.644659604521324 NA NA NA 0.692879608407841 99.482402686627 a7479 POLR2B_mut 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 3 40 -1.38629436111989 0.693147180559945 -2.46835532118411 -2.20192283736699 -0.266432483817128 1.43331604649531 0.927110947740537 0.278104668706572 0.185885370130753 0.287379287739456 0.644686848003139 NA NA NA 0.77965341338643 99.482402686627 a7480 loss_cnaBRCA22_(SYNCRIP,ZNF292) 193 GW-2580 CSF1R (cFMS) 18 30 2.99573227355399 NA 5.52820512533434 5.42449911284401 0.103706012490328 0.977509677487442 0.575616093033374 0.138334546097871 0.106092057069849 0.180165241634957 0.64484455944893 NA NA NA 0.685760340293947 99.482402686627 a7481 CDH1_mut 228 KIN001-102 AKT1 4 45 2.32630161961136 NA 1.62959372821287 1.97162447311498 -0.342030744902108 1.86326542354574 1.37800649918391 0.241894776823024 0.183565229397771 0.248206917097029 0.645058094102744 NA NA NA 0.741691995403931 99.482402686627 a7482 loss_cnaBRCA20 150 Bicalutamide ANDR (androgen receptor) 3 45 0.0237165266173161 NA 2.92501887563555 2.75175900130718 0.173259874328374 0.246200399056036 0.638653172455595 0.276454461749591 0.703735148247826 0.271289460071413 0.645100536493594 NA NA NA 0.366429209730113 99.482402686627 a7483 loss_cnaBRCA36_(FAT1,IRF2) 333 T0901317 LXR 9 39 2.32630161961136 NA 4.62838887955749 4.7601394352156 -0.131750555658106 0.475282779963383 0.816908825863602 0.171442288978177 0.277204563708908 0.161279388209358 0.645114941558816 NA NA NA 0.528414150098419 99.482402686627 a7484 gain_cnaBRCA62 1025 SB 216763 GSK3A, GSK3B 8 31 2.30258509299405 NA 5.00502917235512 4.85925995540936 0.145769216945758 0.892338115662406 0.766494618645537 0.184089629947187 0.163356483811688 0.190176438816159 0.645210811568446 NA NA NA 0.681055236453927 99.482402686627 a7485 ARID1A_mut 301 PHA-793887 CDK-pan 5 43 2.32630161961136 NA 3.24594643990059 2.88463309989613 0.361313340004454 0.95424132394028 1.70185866908686 0.218931574750839 0.378639376580873 0.212305138239428 0.645300063864241 NA NA NA 0.491640315799383 99.482402686627 a7486 PIK3CA_mut 328 SNX-2112 HSP90 17 31 0.940007258491471 NA 0.232055892447521 0.518792508156226 -0.286736615708705 2.07468555464004 2.03758909389489 0.139832753450762 0.138207264743044 0.140723473917208 0.645310243389579 NA NA NA 0.647971887846122 99.482402686627 a7487 loss_cnaBRCA17 62 BMS-536924 IGF1R 3 9 1.63315443905142 NA 3.41888357795541 3.07975609319675 0.339127484758659 0.477065839782585 1.17488204519621 0.316265977653736 0.710860968190912 0.288648112502242 0.645404750386782 NA NA NA 0.496626196176058 99.482402686627 a7488 gain_cnaBRCA15 1262 UNC1215 LMBL3 21 25 0 NA 2.80201275739695 2.7201466539027 0.0818661034942547 0.655044869933906 0.544423654578796 0.137071429707657 0.124977856100934 0.150372054567673 0.645595718866209 NA NA NA 0.651206572733449 99.482402686627 a7489 gain_cnaBRCA10_(MDM2,NUP107) 1192 GSK269962A ROCK1, ROCK2 3 43 1.6094379124341 NA 3.04830784389595 2.64140660049861 0.406901243397336 2.52971543439094 1.40152029595367 0.276486485522485 0.160848622681271 0.290328470142103 0.645639568726683 NA NA NA 0.807723511015422 99.482402686627 a7490 NF1_mut 194 AUY922 HSP90 5 42 -1.36257783450257 NA -2.0539059837197 -2.43420434756209 0.38029836384239 1.19842232729623 1.7806652051654 0.218960911405329 0.317332508899749 0.213570952439128 0.645712273289335 NA NA NA 0.549845196108828 99.482402686627 a7491 MLL3_mut 305 TPCA-1 IKK 3 46 2.99573227355399 NA 3.81914015541871 4.20175155328289 -0.382611397864185 1.8459118029998 1.36417354096118 0.275640130943812 0.207275015654812 0.280471205734282 0.645802187350854 NA NA NA 0.755930728004757 99.482402686627 a7492 loss_cnaBRCA34 269 NSC-207895 MDM4 5 44 2.99573227355399 NA 4.36990263289144 4.63053782751812 -0.260635194626676 0.732646654366967 1.22818630184076 0.218278993988015 0.355744741442755 0.212211448895047 0.64584668631285 NA NA NA 0.511233938139781 99.482402686627 a7493 gain_cnaBRCA8_(CHD4,WNK1) 1067 CCT007093 PPM1D 3 43 1.88706964903238 NA 3.82965648332251 4.10349527557489 -0.273838792252385 1.18689069277221 0.980756411919711 0.276309908133499 0.230719470562856 0.279211829690085 0.645849878790692 NA NA NA 0.73089370914497 99.482402686627 a7494 gain_cnaBRCA61_(NOTCH2) 271 VNLG/124 HDAC, RAR 3 46 1.63315443905142 NA 4.36289192465647 4.13764976960726 0.225242155049205 0.134082499266128 0.834866989060475 0.275566402714737 1.67987736119195 0.269794060611599 0.645890246114175 NA NA NA 0.137553463571908 99.482402686627 a7495 PTEN_mut 277 ABT-869 VEGFR and PDGFR family 9 39 0.0237165266173161 NA 2.62466389011629 2.70640463818819 -0.081740748071895 0.528286536350046 0.466641171628749 0.171029503306327 0.154728054658832 0.175168315703027 0.645909043369716 NA NA NA 0.677353242098685 99.482402686627 a7496 NF1_mut 219 AT-7519 CDK9 5 44 2.32630161961136 NA 1.31524204843797 1.71254123688088 -0.397299188442904 1.61868638021986 1.83912714299496 0.218127843629111 0.245445438534511 0.216025950112353 0.646074643132641 NA NA NA 0.629117536851054 99.482402686627 a7497 NF1_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 5 38 2.30258509299405 NA 3.58502715209994 3.83843268272101 -0.253405530621067 0.993542513270819 1.16746638243218 0.220035964729037 0.255052528941954 0.217055955044416 0.646149489867635 NA NA NA 0.620056438511512 99.482402686627 a7498 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 152 CP466722 ATM 9 40 2.77258872223978 NA 2.58176343664858 2.76352688358368 -0.181763446935101 0.839172806687136 1.10772623911654 0.1703819303705 0.216598351956449 0.164086974305191 0.646337926643012 NA NA NA 0.589904020570829 99.482402686627 a7499 loss_cnaBRCA38 1036 PLX4720 BRAF 3 40 2.30258509299405 NA 4.90786529172437 4.57327195832068 0.334593333403693 0.283461408380971 1.23833699465223 0.276665724247373 1.1803840787879 0.270195701855503 0.646395105535267 NA NA NA 0.217243143831969 99.482402686627 a7500 gain_cnaBRCA9_(KRAS) 290 KIN001-260 IKK 4 45 2.99573227355399 NA 5.27561903117194 5.02349182201955 0.252127209152395 0.612654195560908 1.07051375699814 0.24074330373802 0.411532657377075 0.235519821678324 0.646628776420137 NA NA NA 0.499297455894828 99.482402686627 a7501 loss_cnaBRCA20 157 JNK-9L JNK 3 44 1.63315443905142 NA -0.217774742573673 0.0745001414896296 -0.292274884063303 0.447924567128669 1.08152854502258 0.275359464138241 0.652509162283446 0.270242413303294 0.646688546005648 NA NA NA 0.39478449351527 99.482402686627 a7502 gain_cnaBRCA63 253 XMD14-99 EPHB3, CAMK1 7 41 2.32630161961136 NA 4.80792264932577 4.95447389720542 -0.146551247879647 1.41582817805819 0.627622964041775 0.188569870207516 0.103509204118711 0.233502048643798 0.646901599792047 NA NA NA 0.796104088785436 99.482402686627 a7503 gain_cnaBRCA48 135 Gemcitabine DNA replication 4 43 0.0237165266173161 NA -0.887882937550766 -0.218232175519249 -0.669650762031517 3.63559444352564 2.7066451167823 0.241032840614148 0.18419292152458 0.247409886829792 0.646950563384879 NA NA NA 0.741085894338555 99.482402686627 a7504 gain_cnaBRCA61_(NOTCH2) 305 TPCA-1 IKK 3 46 2.99573227355399 NA 4.53625444056648 4.15498323033847 0.381271210228002 0.584134743913587 1.41326149516755 0.274670263224095 0.65271106401506 0.269781078400357 0.646960977193772 NA NA NA 0.393377424619721 99.482402686627 a7505 loss_cnaBRCA34 277 ABT-869 VEGFR and PDGFR family 5 43 0.0237165266173161 NA 2.59781906485404 2.70192233897944 -0.104103274125394 0.43603418428984 0.481741813254548 0.217816254972414 0.238750258296709 0.216097650777071 0.646980015890816 NA NA NA 0.637765395119906 99.482402686627 a7506 loss_cnaBRCA57 1046 681640 WEE1, CHEK1 3 33 0.693147180559945 NA 2.35948801215068 2.65873187191461 -0.299243859763925 0.214626478416465 1.10574382470814 0.278627819766772 1.39425415713744 0.270626751944928 0.646987157511124 NA NA NA 0.208474119465803 99.482402686627 a7507 gain_cnaBRCA62 1036 PLX4720 BRAF 7 36 2.30258509299405 NA 4.40367717919972 4.63413149871117 -0.230454319511451 2.44213514759251 0.831236597004627 0.190554254118355 0.0943659157187251 0.277242749347053 0.647020481448553 NA NA NA 0.812866202112445 99.482402686627 a7508 gain_cnaBRCA8_(CHD4,WNK1) 1166 QL-VIII-58 MTOR, ATR 3 23 2.30258509299405 NA -1.23414168833345 -1.5561860367888 0.32204434845535 1.98178619679471 1.02169233964249 0.284188577706999 0.162502064539665 0.315206776012473 0.647562811427555 NA NA NA 0.806454606469474 99.482402686627 a7509 loss_cnaBRCA20 1022 AZD7762 CHEK1, CHEK2 3 42 0.693147180559945 NA 1.32371779707348 0.874824463371627 0.448893333701856 0.626891266326848 1.66545687414599 0.275078370298936 0.716062510061852 0.269531646643231 0.647624382187309 NA NA NA 0.363460145014629 99.482402686627 a7510 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 330 XMD13-2 RIPK 14 34 2.32630161961136 NA 3.59452797876516 3.77310670661569 -0.178578727850532 1.32126150979354 1.18202086540059 0.146019387430866 0.135157746234837 0.151079167109298 0.6478072610221 NA NA NA 0.665232787892201 99.482402686627 a7511 loss_cnaBRCA38 1006 Cytarabine DNA synthesis 3 42 0.693147180559945 NA 1.60291090109763 1.18036344434371 0.422547456753912 1.6823126225859 1.52960502018716 0.274909120227558 0.251170591649255 0.276246123134592 0.647826028619502 NA NA NA 0.709615858393086 99.482402686627 a7512 gain_cnaBRCA48 1052 RO-3306 CDK1 4 39 1.6094379124341 NA 3.2609226495206 3.55282727974289 -0.291904630222298 1.34009011521705 1.19731535871489 0.241576019873916 0.217824627543812 0.243799286543527 0.647852903169196 NA NA NA 0.699673829438032 99.482402686627 a7513 loss_cnaBRCA38 235 QL-XII-47 BTK, BMX 4 45 2.32630161961136 NA 1.37523509792304 1.73766087232263 -0.362425774399592 0.921326966190732 1.54401526564418 0.239707371851138 0.393373674818244 0.234729398383497 0.648043243662916 NA NA NA 0.515123307600819 99.482402686627 a7514 BRCA2_mut 1004 Vinblastine Microtubules 5 40 -2.30258509299405 NA -3.7056820750775 -3.42429514072188 -0.281386934355619 0.816490589707363 1.32965082323956 0.218036173205974 0.344629733523898 0.211624683290946 0.64807550252201 NA NA NA 0.525602460648503 99.482402686627 a7515 loss_cnaBRCA29_(MAP2K4) 305 TPCA-1 IKK 7 42 2.99573227355399 NA 3.95531688974421 4.21549461164428 -0.260177721900075 1.11854331071355 1.42330517712987 0.187430364075675 0.232604065848911 0.182798268481486 0.648272412676277 NA NA NA 0.597478773149333 99.482402686627 a7516 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 37 1.38629436111989 0.693147180559945 3.63607725404636 3.40604499744481 0.230032256601547 0.979327663651009 1.05816301213568 0.218964534299881 0.234887939082584 0.217388298365557 0.648325552103719 NA NA NA 0.64482077295828 99.482402686627 a7517 BRCA1_mut 134 Etoposide TOP2 4 43 2.77258872223978 NA 2.95330968818994 2.43280327912429 0.520506409065645 1.30350907225341 2.21975745918357 0.239782972364496 0.399311688844507 0.234487964850488 0.648653771838473 NA NA NA 0.511336635216316 99.482402686627 a7518 MACF1_mut 1175 AG-014699 PARP1, PARP2 3 40 1.6094379124341 NA 3.59765883526074 3.88136403454989 -0.28370519928915 0.760119859869785 1.04459555776265 0.27476472263616 0.373237451443185 0.271593342687385 0.648654864674123 NA NA NA 0.593757865350824 99.482402686627 a7519 BRCA2_mut 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 5 42 2.99573227355399 NA 3.56936121393969 3.88079344865675 -0.311432234717053 1.85163509391052 1.38802181516841 0.216979271557459 0.168193093629118 0.224371282434971 0.648694924443834 NA NA NA 0.732073116136162 99.482402686627 a7520 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1020 Lenalidomide TNFA 8 37 1.6094379124341 NA 4.14966594642811 4.27744238887464 -0.127776442446527 1.01699429819599 0.639020212718286 0.178880283570253 0.125641257451674 0.199956808725952 0.648704585673473 NA NA NA 0.741564669744189 99.482402686627 a7521 CDH1_mut 1047 Nutlin-3a MDM2 4 39 2.07944154167984 1.38629436111989 4.42790382012366 4.18428208066728 0.243621739456382 1.19655842382926 0.994994680918015 0.240945637705471 0.203602042829415 0.24484727821018 0.648707717073471 NA NA NA 0.717106925415222 99.482402686627 a7522 ARID1A_mut 197 Bryostatin 1 PRKC 5 43 -4.8283137373023 NA -2.99533773811334 -2.78488138646001 -0.210456351653332 0.781121665947145 0.987756139161866 0.216622699931145 0.269428388467684 0.213065090976715 0.648779870220886 NA NA NA 0.601452643711949 99.482402686627 a7523 loss_cnaBRCA28_(GPS2) 165 DMOG Prolyl-4-Hydroxylase 4 42 8.29404964010203 NA 7.23178565488721 7.60218961816576 -0.370403963278555 1.71725043372733 1.53008002842732 0.239966890707573 0.21569594975998 0.242081431295637 0.648783988651792 NA NA NA 0.701861081945627 99.482402686627 a7524 gain_cnaBRCA9_(KRAS) 277 ABT-869 VEGFR and PDGFR family 4 44 0.0237165266173161 NA 2.58619079212268 2.70061347117944 -0.114422679056753 0.206103907410987 0.491338017241767 0.239401526161949 0.555169867927761 0.232879759028397 0.64880993283864 NA NA NA 0.398189309699489 99.482402686627 a7525 PIK3CA_mut 151 QS11 ARFGAP 17 31 2.32630161961136 NA 3.62744817945469 3.83338631617866 -0.205938136723972 1.66472163392494 1.38560566712089 0.13834005209946 0.123707250826331 0.14862680025832 0.648832513498714 NA NA NA 0.667434134016932 99.482402686627 a7526 gain_cnaBRCA16 310 YM201636 FYV1 16 33 1.63315443905142 NA 2.31855131494393 2.46126926263847 -0.142717947694542 0.933781105353046 1.06121953004858 0.139608150646144 0.152838761543138 0.134484848472406 0.64886420355054 NA NA NA 0.634763560442989 99.482402686627 a7527 loss_cnaBRCA33 1494 SN-38 TOP1 5 43 -2.99573227355399 NA -3.63207384889666 -3.26561579608951 -0.366458052807144 1.76110018154459 1.68574178247049 0.216528014995614 0.208084728312128 0.217386824374782 0.648922743922489 NA NA NA 0.67712183269991 99.482402686627 a7528 NF1_mut 1003 Camptothecin TOP1 4 41 -2.30258509299405 NA -2.17974243412354 -2.56338281084948 0.383640376725944 2.06400153185121 1.55683775673656 0.240157265660532 0.185872137595681 0.246422836975723 0.648923298750559 NA NA NA 0.739163765055112 99.482402686627 a7529 gain_cnaBRCA62 54 CGP-082996 CDK4 4 8 1.63315443905142 NA 3.00945509360032 2.70890408164701 0.300551011953305 0.63031797490138 1.18012299282382 0.287339254773602 0.476824434525018 0.254677702053868 0.648973364810043 NA NA NA 0.578371624593202 99.482402686627 a7530 gain_cnaBRCA62 266 Zibotentan, ZD4054 Endothelin A Receptor 10 39 2.99573227355399 NA 5.67807423918793 5.75844070381454 -0.0803664646266133 0.804572009361818 0.386975916658846 0.162353930179942 0.099887224128465 0.20767820726545 0.649039216394777 NA NA NA 0.765158968120759 99.482402686627 a7531 BRCA2_mut 295 NVP-BHG712 EPHB4 6 43 2.32630161961136 NA 3.6703400977636 3.91689915759278 -0.246559059829181 1.01131549996552 1.25935904810526 0.199587844877242 0.243800337122873 0.195781385936072 0.64907770212078 NA NA NA 0.60418627292111 99.482402686627 a7532 loss_cnaBRCA33 178 BAY 61-3606 SYK 6 42 2.07944154167984 NA 2.81330679663443 3.13610225380691 -0.322795457172487 1.30849240525552 1.64853397521302 0.199867811801754 0.246692648635933 0.195807585421936 0.649141016588038 NA NA NA 0.60124865613091 99.482402686627 a7533 MLL3_mut 1058 GDC0941 PI3K (class 1) 3 40 1.38629436111989 0.693147180559945 1.70195256236019 1.31930632008433 0.382646242275854 0.663519789813815 1.42216955507084 0.27434381497776 0.576691529250733 0.269058102749776 0.649155661042965 NA NA NA 0.442673199364524 99.482402686627 a7534 gain_cnaBRCA12_(TERT) 273 CUDC-101 HDAC, EGFR 9 40 1.63315443905142 NA -0.244052488603646 0.0222673835998051 -0.266319872203451 0.790744013118577 1.6935146820447 0.168900488067746 0.336796571058597 0.157258673353752 0.649199365542765 NA NA NA 0.484498588761304 99.482402686627 a7535 gain_cnaBRCA9_(KRAS) 255 CP724714 ERBB2 4 44 2.32630161961136 NA 4.170617582683 3.76961914908655 0.40099843359645 1.60381291377402 1.68243970681892 0.239056065380486 0.250028186051226 0.238343419958057 0.649281629127616 NA NA NA 0.660803206840731 99.482402686627 a7536 gain_cnaBRCA31 1527 GDC0941 (rescreen) PI3K 14 31 1.38629436111989 NA 0.862545793033229 1.03399586319024 -0.171450070157012 1.34037004776834 1.07659782735695 0.1474622211119 0.127912489869845 0.159251733377469 0.649293245647756 NA NA NA 0.677931094786096 99.482402686627 a7537 CDH1_mut 1072 BMS-708163 g-secretase 5 41 1.6094379124341 NA 3.86982597030971 3.66161852483886 0.208207445470851 1.18688783385804 0.934532943189219 0.216833342538386 0.175423017686567 0.222793050783544 0.64938780504685 NA NA NA 0.721998331141272 99.482402686627 a7538 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1008 Methotrexate Dihydrofolate reductase (DHFR) 6 39 -1.6094379124341 NA 0.49202237149175 0.711977413364956 -0.219955041873206 1.00057532688067 1.10769218831677 0.200730138929405 0.219828568588557 0.198570545313176 0.649447378785987 NA NA NA 0.636423010599362 99.482402686627 a7539 gain_cnaBRCA9_(KRAS) 294 MPS-1-IN-1 MPS1 4 45 2.99573227355399 NA 4.49820902938169 4.77947847393841 -0.281269444556716 0.379112810004642 1.21394129695757 0.238675724476641 0.741914905363582 0.231699378925196 0.6494531651265 NA NA NA 0.307483576274743 99.482402686627 a7540 loss_cnaBRCA7_(FAS,PTEN) 328 SNX-2112 HSP90 4 44 0.940007258491471 NA 0.8662421362988 0.376421576801265 0.489820559497535 1.95898099304799 2.05693576665582 0.238856457847094 0.250038444086903 0.238131188847909 0.6495542418868 NA NA NA 0.660808087843929 99.482402686627 a7541 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 286 KIN001-236 TIE2 6 43 2.32630161961136 NA 4.67487389755266 4.52129888770294 0.153575009849719 0.686157868280442 0.780498744951228 0.199186438812648 0.223818769628903 0.196765223317964 0.649734766366556 NA NA NA 0.629472335945748 99.482402686627 a7542 NF1_mut 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 4 39 1.6094379124341 NA 2.55521423469087 2.90003533664143 -0.344821101950565 1.94580991231905 1.38748366124637 0.240173266250824 0.177212121167376 0.248522639640177 0.649755726492656 NA NA NA 0.750446696116402 99.482402686627 a7543 gain_cnaBRCA58_(CCND1) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 10 38 2.32630161961136 NA 5.04841996957527 4.93482472818821 0.113595241387056 0.751866652471452 0.686221760653301 0.162383258177488 0.151084292691608 0.165537218287731 0.649899857964213 NA NA NA 0.67221111405905 99.482402686627 a7544 gain_cnaBRCA58_(CCND1) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 9 39 2.07944154167984 NA 3.37452027888858 3.17733033664573 0.197189942242853 0.782688850613664 1.23300319331699 0.168937695700304 0.251939122536685 0.159926546266582 0.649939580681404 NA NA NA 0.554028392943516 99.482402686627 a7545 gain_cnaBRCA64_(SDHC) 156 AZD6482 PI3Kbeta 8 39 1.63315443905142 NA 2.26947187696994 2.00896886348203 0.260503013487903 1.46663392627832 1.4703375167864 0.177241628721266 0.17761965601665 0.177172255018877 0.650111293722654 NA NA NA 0.657033640378712 99.482402686627 a7546 ARID1A_mut 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 5 41 2.30258509299405 NA 1.22035031334268 1.4366901106441 -0.216339797301425 0.900048515710443 1.01019295089479 0.216192587730993 0.24036459538035 0.214156906469997 0.650352470267273 NA NA NA 0.636836163910077 99.482402686627 a7547 loss_cnaBRCA57 1170 CCT018159 HSP90 3 40 2.30258509299405 NA 3.64737429017469 3.31998746926283 0.327386820911864 0.949922709584806 1.20970799280384 0.273199625829457 0.344645746025967 0.270632931963235 0.650517849309797 NA NA NA 0.619283163937681 99.482402686627 a7548 ARID1A_mut 287 KIN001-244 PDPK1 (PDK1) 5 44 2.99573227355399 NA 3.29505154282752 3.49890768947419 -0.20385614664667 1.23377928072744 0.916533059160345 0.21511155402273 0.165229024211264 0.222420942277223 0.650630797710629 NA NA NA 0.736183619007939 99.482402686627 a7549 gain_cnaBRCA15 305 TPCA-1 IKK 22 27 2.99573227355399 NA 4.07826222904084 4.25986010660632 -0.181597877565475 1.43544222314086 1.34879631188432 0.130817337611026 0.126510057066682 0.134636991490417 0.650867917424712 NA NA NA 0.653122759341325 99.482402686627 a7550 loss_cnaBRCA38 1114 Cetuximab EGFR 3 42 4.18661983833127 NA 6.05823205320202 6.29861026955673 -0.240378216354705 0.911334879215911 0.881304350552931 0.272314197819893 0.263764969208158 0.272752785350364 0.650920989880945 NA NA NA 0.696798541299145 99.482402686627 a7551 gain_cnaBRCA14_(RAD21) 346 THZ-2-102-1 CDK7 21 27 0.916290731874155 2.99573227355399 -1.52579947992473 -1.18688065104307 -0.338918828881659 2.66849403951894 2.46986251354436 0.132487470598601 0.127007527040516 0.137221738871325 0.650999281065892 NA NA NA 0.654427777299375 99.482402686627 a7552 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 177 GSK-650394 SGK3 6 41 2.77258872223978 NA 3.7183853198342 4.05776371241395 -0.339378392579753 1.63383368146086 1.7138613809113 0.199030828316302 0.207719057594837 0.198019744396888 0.651051767448309 NA NA NA 0.651732708179382 99.482402686627 a7553 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 7 36 1.6094379124341 NA 3.18438701333922 2.89953540544073 0.284851607898488 1.11943002261961 1.572106275288 0.188103183873191 0.254461290248315 0.1811910634644 0.651247206193066 NA NA NA 0.578373870952353 99.482402686627 a7554 gain_cnaBRCA9_(KRAS) 186 Bexarotene Retinioic acid X family agonist 4 43 2.07944154167984 NA 3.35498222383519 3.62760762394008 -0.272625400104888 0.683125783854882 1.17244072705263 0.237823236208651 0.399085214682517 0.232528087616194 0.651328150265816 NA NA NA 0.512034826044806 99.482402686627 a7555 loss_cnaBRCA23 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 3 45 2.07944154167984 NA 3.51078329631037 3.19453812778333 0.316245168527042 1.75037627649985 1.13365377795171 0.270928762080115 0.180672677511045 0.27896097969032 0.651705595518596 NA NA NA 0.78537727077431 99.482402686627 a7556 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 155 AP-24534 ABL 6 41 -0.669430653942629 NA 1.24769262220276 1.47428665926197 -0.226594037059209 0.473608395499039 1.19849596780061 0.198605067718679 0.47844176584 0.189065331170899 0.651747259159594 NA NA NA 0.411527379668619 99.482402686627 a7557 PIK3CA_mut 302 PI-103 PI3Ka, PRKDC (DNAPK) 16 32 2.32630161961136 NA 1.30119340774124 1.04205303523649 0.259140372504748 2.04514872070345 1.76950628209342 0.139033195738595 0.126709793709092 0.146447839788492 0.651906205382423 NA NA NA 0.668985643876004 99.482402686627 a7558 gain_cnaBRCA47_(EGFR) 134 Etoposide TOP2 7 40 2.77258872223978 NA 2.13344959001445 2.53724081562508 -0.403791225610624 1.62385961259221 2.24318679117028 0.186006671263313 0.248661412895196 0.180007847407109 0.652008948209559 NA NA NA 0.58091805081931 99.482402686627 a7559 gain_cnaBRCA27_(CLTC,PPM1D) 1031 Elesclomol HSP70 10 34 -1.6094379124341 NA -3.20427470742365 -2.91090388326106 -0.293370824162586 1.24362168016166 1.9188905942249 0.163374439178167 0.235900377777629 0.152885643947349 0.652060775400871 NA NA NA 0.572814746013615 99.482402686627 a7560 gain_cnaBRCA63 17 Cyclopamine SMO 3 10 2.77258872223978 NA 4.89330170878425 4.63634189809241 0.256959810691846 0.555502654019272 0.893537276826722 0.305094952930597 0.462571706602381 0.287575926999268 0.652061405364985 NA NA NA 0.571384999180373 99.482402686627 a7561 gain_cnaBRCA47_(EGFR) 1052 RO-3306 CDK1 6 37 1.6094379124341 NA 3.31787209308168 3.55937086350176 -0.241498770420083 1.97868290641911 1.0579730916049 0.19984746905373 0.122050263656005 0.228265512928822 0.652159622422229 NA NA NA 0.780845182093258 99.482402686627 a7562 CDH1_mut 1052 RO-3306 CDK1 4 39 1.6094379124341 NA 3.26448301642751 3.55246211390629 -0.287979097478777 1.52776023355828 1.17953005299022 0.238310868634925 0.188497573868676 0.244147316762911 0.65228571610415 NA NA NA 0.736129750497261 99.482402686627 a7563 loss_cnaBRCA28_(GPS2) 1248 FK866 NAMPT 3 41 0 NA 0.039725117221397 -0.701225210921293 0.74095032814269 2.95453164975011 2.71804476154825 0.271433180021144 0.250784359749661 0.272604167019174 0.652290689741557 NA NA NA 0.710209801862988 99.482402686627 a7564 loss_cnaBRCA60 1248 FK866 NAMPT 3 41 0 NA 0.039725117221397 -0.701225210921293 0.74095032814269 2.95453164975011 2.71804476154825 0.271433180021144 0.250784359749661 0.272604167019174 0.652290689741557 NA NA NA 0.710209801862988 99.482402686627 a7565 gain_cnaBRCA47_(EGFR) 1043 JNK Inhibitor VIII JNK 6 37 2.30258509299405 NA 4.6683395947488 4.8182487357323 -0.149909140983493 0.976662172181775 0.713370336519969 0.199761325506624 0.15349129438341 0.210142100545972 0.652299331519781 NA NA NA 0.730895621109716 99.482402686627 a7566 gain_cnaBRCA27_(CLTC,PPM1D) 1046 681640 WEE1, CHEK1 9 27 0.693147180559945 NA 2.77463239114629 2.5868490477525 0.187783343393794 1.10762515311036 1.06357730359454 0.174827892816799 0.169536907740379 0.17655824617463 0.65255973096461 NA NA NA 0.663605792915395 99.482402686627 a7567 loss_cnaBRCA36_(FAT1,IRF2) 222 BX-912 PDPK1 (PDK1) 9 40 2.32630161961136 NA 3.6764333699553 3.93043394710058 -0.254000577145278 1.21355227444749 1.57511871092715 0.16714271756205 0.209303367060081 0.16125805336651 0.652601479831171 NA NA NA 0.600811909990212 99.482402686627 a7568 gain_cnaBRCA12_(TERT) 1494 SN-38 TOP1 10 38 -2.99573227355399 NA -3.08801917756107 -3.36056991317688 0.272550735615813 1.72076983161809 1.68556955011304 0.161033060079257 0.158388838883539 0.161696523052125 0.652612678238386 NA NA NA 0.661376380113315 99.482402686627 a7569 TP53_mut 167 OSU-03012 PDPK1 (PDK1) 38 10 2.77258872223978 NA 2.28788700007694 2.09632873211229 0.191558267964655 0.988722704161206 1.79547601780621 0.160919992570263 0.193743166975382 0.106689404962763 0.652840069822166 NA NA NA 0.751816515705438 99.482402686627 a7570 gain_cnaBRCA47_(EGFR) 1020 Lenalidomide TNFA 7 38 1.6094379124341 NA 4.14238224291456 4.27542158577328 -0.133039342858715 0.55928310990311 0.736434303257035 0.186236307962159 0.237874773085428 0.180653375691926 0.652974817934864 NA NA NA 0.595454214176314 99.482402686627 a7571 MLL3_mut 1241 CHIR-99021 GSK3B 3 43 2.30258509299405 NA 3.98322932543178 4.24880740181637 -0.265578076384589 1.32701776771564 0.963699953991094 0.27013484752652 0.20013151507516 0.275581704953618 0.653222917938178 NA NA NA 0.763947820993357 99.482402686627 a7572 loss_cnaBRCA33 1133 JNJ-26854165 MDM2 4 39 2.30258509299405 NA 2.77973094051632 2.98820909780469 -0.208478157288372 0.756111052309404 0.886454214937867 0.237562019193305 0.275724255916659 0.235182092628422 0.65330416970713 NA NA NA 0.633565523895803 99.482402686627 a7573 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1008 Methotrexate Dihydrofolate reductase (DHFR) 6 39 -1.6094379124341 NA 0.870991064479854 0.653674537520633 0.217316526959221 1.26815077227954 1.07110417571799 0.198310718767393 0.171364897384078 0.202890187421357 0.653385078320752 NA NA NA 0.703761769486873 99.482402686627 a7574 gain_cnaBRCA10_(MDM2,NUP107) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 40 1.6094379124341 NA 2.16103854332112 2.59781411176134 -0.436775568440216 2.21680795012553 1.57582558331502 0.270782358248467 0.197029051801931 0.277172532966106 0.653399651152551 NA NA NA 0.767475850347261 99.482402686627 a7575 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 228 KIN001-102 AKT1 6 43 2.32630161961136 NA 1.69934356595816 1.97780034435527 -0.278456778397106 1.32022308399177 1.42489341259648 0.19691078778647 0.210916459326839 0.195422882817385 0.653465099615853 NA NA NA 0.646985757932981 99.482402686627 a7576 gain_cnaBRCA12_(TERT) 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 5 21 2.30258509299405 NA 4.50252340719528 4.72942709571999 -0.226903688524708 1.2256306169643 0.952346435288848 0.22620749273392 0.185132196751671 0.238257508105112 0.65349295125942 NA NA NA 0.714002901481047 99.482402686627 a7577 loss_cnaBRCA38 1268 XAV 939 TNKS1 (tankyrase-1) 3 44 1.6094379124341 NA 3.42307096801461 3.67769530288716 -0.254624334872549 0.532524479055126 0.95927135666589 0.269612508106807 0.4781457846301 0.265435148358373 0.653559570180694 NA NA NA 0.508421692367026 99.482402686627 a7578 gain_cnaBRCA31 17 Cyclopamine SMO 4 9 2.77258872223978 NA 4.53399589038237 4.76748228286082 -0.233486392478443 1.41084302595135 0.478646275764943 0.277199389968877 0.165494238681159 0.487805722723527 0.653579652189037 NA NA NA 0.76614702392538 99.482402686627 a7579 gain_cnaBRCA61_(NOTCH2) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 3 45 2.32630161961136 NA 5.13515067899711 4.94671305177585 0.188437627221264 0.285051713190998 0.7127223873855 0.269356013570337 0.661064706862512 0.264391340241907 0.653590758310538 NA NA NA 0.390763193461578 99.482402686627 a7580 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 15 32 2.99573227355399 NA 3.70956084094748 3.91239744684592 -0.202836605898438 1.43803106645737 1.43422575756876 0.141309106958242 0.14105161608096 0.141425856304713 0.65373526212738 NA NA NA 0.655434206604534 99.482402686627 a7581 gain_cnaBRCA48 1527 GDC0941 (rescreen) PI3K 5 40 1.38629436111989 NA 0.759205525381166 1.00833713086142 -0.249131605480255 0.878810487253946 1.18803864989049 0.214261115074369 0.283487292304313 0.20969991633119 0.653753819030487 NA NA NA 0.588127753351423 99.482402686627 a7582 loss_cnaBRCA57 1018 ABT-888 PARP1, PARP2 5 40 1.6094379124341 NA 4.53033373020508 4.38716899974904 0.143164730456045 0.456597122602835 0.686209269464505 0.214258530847976 0.313547158685394 0.208631297807688 0.653757713303835 NA NA NA 0.556815539983143 99.482402686627 a7583 BRCA2_mut 1143 HG-5-88-01 EGFR, ADCK4 3 23 2.30258509299405 NA 4.29038170650533 4.56586339615406 -0.275481689648727 0.755703849702379 1.00683220512045 0.278730288551968 0.364536570453122 0.273612314194667 0.65385879303921 NA NA NA 0.608966772520964 99.482402686627 a7584 gain_cnaBRCA8_(CHD4,WNK1) 1021 Axitinib PDGFR, KIT, VEGFR 3 42 0.693147180559945 NA 2.16589381130223 2.48352743557435 -0.317633624272114 0.779575810918862 1.19310738443282 0.269844391243327 0.407444176465313 0.266223835688614 0.653872524301525 NA NA NA 0.564575104121202 99.482402686627 a7585 loss_cnaBRCA34 302 PI-103 PI3Ka, PRKDC (DNAPK) 5 43 2.32630161961136 NA 0.77256706768582 1.16981293751159 -0.39724586982577 0.78720181894447 1.93548292418032 0.213122814552749 0.504630274303002 0.205243799809809 0.654069815334908 NA NA NA 0.405542862956793 99.482402686627 a7586 PIK3CA_mut 37 Crizotinib MET, ALK 4 10 0.693147180559945 NA 2.80722297458171 2.59032028533465 0.216902689247061 0.668507275253306 0.836660902343157 0.271824402548394 0.324458232956214 0.259248028250875 0.654111186381301 NA NA NA 0.626485308631563 99.482402686627 a7587 gain_cnaBRCA27_(CLTC,PPM1D) 295 NVP-BHG712 EPHB4 9 40 2.32630161961136 NA 4.05442613408149 3.84897172890844 0.205454405173054 1.07486148504973 1.2658484150522 0.166302366697399 0.191145006152629 0.162305693738679 0.654230599736464 NA NA NA 0.624700350924133 99.482402686627 a7588 loss_cnaBRCA17 1032 Afatinib ERBB2, EGFR 8 37 -0.693147180559945 NA 0.556739601977005 0.232900259782845 0.32383934219416 1.574010282204 1.89008397962863 0.175777143083013 0.205741567164801 0.171335954213944 0.654385340851517 NA NA NA 0.620739231396914 99.482402686627 a7589 PTEN_mut 226 GSK1070916 AURKB 9 40 0.940007258491471 2.32630161961136 2.13825116016484 2.46372943274424 -0.325478272579398 2.47524781922936 1.83407392071437 0.166222048485006 0.131493206478506 0.17746191628559 0.654386395332651 NA NA NA 0.717486924877149 99.482402686627 a7590 gain_cnaBRCA30_(CRNKL1,FOXA2) 257 NPK76-II-72-1 PLK3 5 44 2.32630161961136 NA 3.78304364838555 3.44440537078242 0.338638277603126 2.23018056911461 1.52027604434705 0.212571287190024 0.151843434694423 0.222747887702571 0.654478402504331 NA NA NA 0.755774881978041 99.482402686627 a7591 gain_cnaBRCA47_(EGFR) 303 PIK-93 PI4K, PI3K 7 42 2.99573227355399 NA 2.56637430309547 2.82905268242961 -0.262678379334139 0.646399333484016 1.51032314733025 0.183766898231989 0.406371674175983 0.17392197146582 0.654682473145907 NA NA NA 0.44590797962329 99.482402686627 a7592 gain_cnaBRCA9_(KRAS) 1042 BIRB 0796 p38, JNK2 4 39 2.30258509299405 NA 4.56593358299 4.34615062862084 0.219782954369156 0.931524809313333 0.929213634825922 0.236482664895826 0.235938916679167 0.236525752670783 0.654773296779497 NA NA NA 0.678519144817046 99.482402686627 a7593 gain_cnaBRCA27_(CLTC,PPM1D) 223 ZSTK474 PI3K 9 40 1.63315443905142 2.32630161961136 0.715195081315363 0.956695109336394 -0.241500028021032 1.76564568096345 1.3830562126457 0.165945383466722 0.136777174845892 0.174613313481349 0.654923169519952 NA NA NA 0.708312044840272 99.482402686627 a7594 TP53_mut 1007 Docetaxel Microtubules 35 10 -4.38202663467388 NA -4.64294725265947 -4.39244306556402 -0.250504187095451 1.56054970122232 1.5206533641033 0.161377790258377 0.160523043193844 0.164734575945365 0.654927208969448 NA NA NA 0.65446173988316 99.482402686627 a7595 loss_cnaBRCA23 1194 SB-505124 TGFR1 (ALK5) 3 44 2.30258509299405 NA 4.62095310205956 4.37318404291678 0.247769059142784 0.775208729163984 0.929419627998937 0.26840598705825 0.31961593029272 0.266584706927523 0.655005969106552 NA NA NA 0.641972994869228 99.482402686627 a7596 gain_cnaBRCA9_(KRAS) 1005 Cisplatin DNA crosslinker 4 41 1.79175946922805 2.30258509299405 3.92545983882834 3.6451687918552 0.28029104697314 0.776188270352488 1.21478284104376 0.235649016260365 0.36111219104851 0.230733459103118 0.655068205317351 NA NA NA 0.54751749354826 99.482402686627 a7597 gain_cnaBRCA12_(TERT) 272 AR-42 HDAC 9 40 1.63315443905142 NA -0.0662859488021591 0.188825898358276 -0.255111847160435 0.870238806492587 1.64185735738849 0.165861434502969 0.293151540999003 0.155380031043751 0.655086080303183 NA NA NA 0.518768258193574 99.482402686627 a7598 loss_cnaBRCA38 1067 CCT007093 PPM1D 3 43 1.88706964903238 NA 3.83685642198637 4.10299295427276 -0.266136532286398 0.716183449837769 1.00240587722375 0.268501913623682 0.371603857009937 0.265497777231201 0.655178555261582 NA NA NA 0.594901223403019 99.482402686627 a7599 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1378 Bleomycin (50 uM) DNA damage 10 38 3.91202300542815 NA 4.05252849041627 3.74960948757969 0.302919002836585 1.83622649168867 1.91044731927598 0.159754391387112 0.164968212912563 0.158559202224632 0.655186164936894 NA NA NA 0.652146692599036 99.482402686627 a7600 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 56 WH-4-023 SRC family, ABL 3 9 1.63315443905142 NA 3.48797321012943 3.13505467433064 0.35291853579879 1.16894075576591 1.14563699479645 0.306796174840186 0.301913107279377 0.308054416365539 0.655220690802071 NA NA NA 0.676548077106108 99.482402686627 a7601 gain_cnaBRCA27_(CLTC,PPM1D) 56 WH-4-023 SRC family, ABL 3 9 1.63315443905142 NA 3.48797321012943 3.13505467433064 0.35291853579879 1.16894075576591 1.14563699479645 0.306796174840186 0.301913107279377 0.308054416365539 0.655220690802071 NA NA NA 0.676548077106108 99.482402686627 a7602 gain_cnaBRCA10_(MDM2,NUP107) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 3 40 1.6094379124341 NA 2.50839983634632 2.89492588896851 -0.386526052622192 1.02096987122815 1.45392846518564 0.269198437518832 0.378587129272707 0.265849429237799 0.655290874017004 NA NA NA 0.589594865485241 99.482402686627 a7603 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 287 KIN001-244 PDPK1 (PDK1) 15 34 2.99573227355399 NA 3.56966763882945 3.43771121966354 0.131956419165912 0.893805160919626 0.969710707227751 0.139233236505411 0.147634434142385 0.136078129469308 0.655359228874827 NA NA NA 0.646191841710092 99.482402686627 a7604 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1 Erlotinib EGFR 3 9 0.693147180559945 NA 3.0608593175473 2.88181035356858 0.179048963978724 0.397420501448255 0.62188556069448 0.306623988944771 0.450527749137865 0.287913042680673 0.655399817174007 NA NA NA 0.584874875516482 99.482402686627 a7605 gain_cnaBRCA31 41 S-Trityl-L-cysteine KIF11 3 9 1.63315443905142 NA 1.60948426190048 1.09569970950938 0.513784552391098 1.0922241140775 1.79242942987744 0.306561815209347 0.470402132464404 0.286641439728106 0.655464502644537 NA NA NA 0.575829767259478 99.482402686627 a7606 gain_cnaBRCA14_(RAD21) 150 Bicalutamide ANDR (androgen receptor) 21 27 0.0237165266173161 NA 2.80864815591128 2.72676297820715 0.0818851777041352 0.65318632267379 0.605742765380606 0.130637582791784 0.125362664314436 0.135181437375788 0.655545321660683 NA NA NA 0.658853296108405 99.482402686627 a7607 gain_cnaBRCA64_(SDHC) 136 Mitomycin C DNA crosslinker 8 40 2.77258872223978 NA 0.0810333808532763 -0.177373019030874 0.25840639988415 1.60782748660292 1.46374811179368 0.173826761715153 0.160717739954876 0.176537477863933 0.65566969932294 NA NA NA 0.683138065873879 99.482402686627 a7608 loss_cnaBRCA57 1239 YK 4-279 RNA helicase A 4 38 2.30258509299405 NA 2.29179082841512 1.98426467506876 0.307526153346355 0.461007042788129 1.3479897626872 0.236088600080585 0.667074740304322 0.228136861168223 0.655761882934033 NA NA NA 0.355565624760374 99.482402686627 a7609 TP53_mut 1259 BMN-673 PARP1 36 10 2.30258509299405 NA 3.36014250662163 3.10896196244649 0.251180544175132 1.36151209460694 2.18548020811205 0.160423558512232 0.184486458232783 0.114931511730375 0.65578773582679 NA NA NA 0.736368265930431 99.482402686627 a7610 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 286 KIN001-236 TIE2 9 40 2.32630161961136 NA 4.64418161461186 4.51668652562589 0.127495088985976 0.552067310658936 0.808703997367686 0.165346758604054 0.230941203227194 0.157653590684564 0.656085227035231 NA NA NA 0.576918784021723 99.482402686627 a7611 loss_cnaBRCA34 154 CHIR-99021 GSK3B 5 42 0.940007258491471 NA 3.10279652723698 3.29598927973474 -0.193192752497755 0.535032398286662 0.939640930426774 0.212070884500987 0.361086082107209 0.205602742751967 0.656107790146127 NA NA NA 0.510989960020592 99.482402686627 a7612 gain_cnaBRCA9_(KRAS) 1031 Elesclomol HSP70 4 40 -1.6094379124341 NA -2.5937110106252 -3.0159658765653 0.422254865940101 2.49968947490559 1.72983893193307 0.235133809270199 0.168922928299344 0.244100683679398 0.656181829942204 NA NA NA 0.761266011752586 99.482402686627 a7613 gain_cnaBRCA13_(FGFR1,WHSC1L1) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 10 37 2.77258872223978 NA 5.14045360556703 4.97588739571389 0.164566209853137 1.02923582901358 1.03071863264938 0.159707548076419 0.159891645057535 0.159661623104777 0.656229294438352 NA NA NA 0.660536700432081 99.482402686627 a7614 PIK3CA_mut 133 Doxorubicin DNA intercalating 17 31 0.0237165266173161 NA -1.19171738014338 -0.942314959586834 -0.249402420556543 2.17679719251047 1.64089260846384 0.135174941766161 0.114573108333032 0.151991921512784 0.656327919286116 NA NA NA 0.683346005848973 99.482402686627 a7615 loss_cnaBRCA29_(MAP2K4) 329 QL-XI-92 DDR1 7 41 2.32630161961136 NA 4.10452480126819 4.27874173425293 -0.174216932984744 1.26678028144473 0.89500921674203 0.183044738605791 0.137527348299149 0.194653786492747 0.656551954099633 NA NA NA 0.737064732084396 99.482402686627 a7616 gain_cnaBRCA10_(MDM2,NUP107) 1047 Nutlin-3a MDM2 3 40 2.07944154167984 1.38629436111989 4.45913369807493 4.18803038330735 0.271103314767579 0.744324697800261 1.02304196253957 0.268092675054412 0.36422721907359 0.264997257878455 0.656612530615101 NA NA NA 0.60217588314074 99.482402686627 a7617 gain_cnaBRCA15 134 Etoposide TOP2 22 25 2.77258872223978 NA 2.62817890212692 2.34415375633249 0.284025145794433 2.38910700024018 1.96031425014684 0.130827923868277 0.118883392734557 0.144887558600952 0.656631490366227 NA NA NA 0.660917702776152 99.482402686627 a7618 gain_cnaBRCA9_(KRAS) 344 THZ-2-49 CDK9 4 45 2.99573227355399 NA 1.46774188556437 1.81350016069178 -0.345758275127416 0.992280644398426 1.50922599445757 0.233363725267001 0.348448069686004 0.229096421872646 0.656733355450202 NA NA NA 0.557502645020073 99.482402686627 a7619 PTEN_mut 283 GSK2126458 PI3K, MTOR 9 39 -2.05572501506252 0.0237165266173161 -3.27614271196142 -3.00440756370992 -0.271735148251497 1.09751364820785 1.73599614863459 0.165401892821972 0.247591589129864 0.156529810544352 0.656776502639103 NA NA NA 0.561364245539563 99.482402686627 a7620 MACF1_mut 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 3 43 0 NA 0.136032444632255 0.689297659429986 -0.553265214797731 1.1698301293189 2.10457229696882 0.267115823930628 0.472944918182144 0.262887245828803 0.656840489089666 NA NA NA 0.513047433950135 99.482402686627 a7621 gain_cnaBRCA47_(EGFR) 186 Bexarotene Retinioic acid X family agonist 7 40 2.07944154167984 NA 3.42573325488254 3.63567309851466 -0.20993984363212 1.03173736963162 1.16306887265539 0.183125252410626 0.20348186448561 0.18050508320527 0.657040684170121 NA NA NA 0.638075240682471 99.482402686627 a7622 loss_cnaBRCA18 1013 Nilotinib ABL 14 26 0.693147180559945 NA 3.10995747092702 3.25295733474016 -0.142999863813139 1.06205522904096 0.908734426686254 0.148350178868306 0.134644470365508 0.157361556483114 0.657043148690192 NA NA NA 0.673526049672846 99.482402686627 a7623 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 262 VX-11e ERK 15 34 1.63315443905142 NA 3.90536051988306 3.72009933786243 0.185261182020633 0.78321073166994 1.51271152197883 0.138494054044093 0.236540658253781 0.122469604633068 0.657067884066416 NA NA NA 0.576046000969575 99.482402686627 a7624 loss_cnaBRCA42 204 Tipifarnib Farnesyl-transferase (FNTA) 3 45 2.77258872223978 NA 1.23983268102774 1.64531945059956 -0.405486769571826 0.926277585846265 1.54387739033229 0.266374267452514 0.437759453286744 0.262641821242394 0.657171072372188 NA NA NA 0.539425178374608 99.482402686627 a7625 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 286 KIN001-236 TIE2 7 42 2.32630161961136 NA 4.41958827555805 4.56018994351514 -0.140601667957085 0.936845882422144 0.74373875621452 0.182341866526231 0.15007982699734 0.189047117394715 0.657183038048979 NA NA NA 0.716353327788343 99.482402686627 a7626 gain_cnaBRCA58_(CCND1) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 8 37 -0.669430653942629 NA -3.13590560248842 -3.56192897946437 0.426023376975945 2.58071402564157 2.4178466584841 0.174235611062454 0.165079653438174 0.176199501933281 0.657215091246466 NA NA NA 0.677825222220887 99.482402686627 a7627 gain_cnaBRCA19 263 FR-180204 ERK 4 45 2.99573227355399 NA 5.51548782927801 5.34387573915565 0.171612090122353 0.741617205602076 0.736710520631058 0.232844425186918 0.231402519825617 0.232943721199138 0.657446888535991 NA NA NA 0.682922962091732 99.482402686627 a7628 gain_cnaBRCA8_(CHD4,WNK1) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 4 45 1.63315443905142 NA 3.79151357093458 3.55755852728325 0.233955043651332 1.07543626781114 1.00030440377755 0.232729064443936 0.217544312623478 0.233883848524334 0.65760544126277 NA NA NA 0.699599352465077 99.482402686627 a7629 loss_cnaBRCA29_(MAP2K4) 1026 17-AAG HSP90 5 38 0 NA -0.55889852527414 -0.940589298245813 0.381690772971673 0.933128805208377 1.86686836568595 0.212374237824123 0.409044036408712 0.204455107809075 0.657642352001306 NA NA NA 0.477904060389579 99.482402686627 a7630 CDH1_mut 1036 PLX4720 BRAF 4 39 2.30258509299405 NA 4.85367631437003 4.57025048591077 0.283425828459264 1.12352375686396 1.21612457665844 0.234315751518032 0.252265096067375 0.233056574876595 0.657726902192681 NA NA NA 0.659947044950313 99.482402686627 a7631 gain_cnaBRCA27_(CLTC,PPM1D) 1023 GW 441756 NTRK1 10 35 0.693147180559945 NA 2.52210061653027 2.31276855499884 0.209332061531435 0.829940303566935 1.40905073977762 0.159891566608672 0.252225443964781 0.148562472324079 0.657895026070416 NA NA NA 0.559980291641215 99.482402686627 a7632 gain_cnaBRCA47_(EGFR) 1378 Bleomycin (50 uM) DNA damage 7 41 3.91202300542815 NA 3.51749853210064 3.8631208709143 -0.345622338813659 1.28126915238922 1.97199625872494 0.182268694766698 0.269749988259039 0.175265210207413 0.65791221651236 NA NA NA 0.558659542160588 99.482402686627 a7633 loss_cnaBRCA36_(FAT1,IRF2) 186 Bexarotene Retinioic acid X family agonist 9 38 2.07944154167984 NA 3.45126290313075 3.64067606833125 -0.189413165200501 0.788061439118502 1.21005374237484 0.165218240155802 0.240353297088578 0.156532853515052 0.657966094122185 NA NA NA 0.570607246474477 99.482402686627 a7634 PIK3CA_mut 173 FH535 unknown 17 31 3.46573590279973 NA 1.68477628096175 1.51170034171352 0.173075939248232 1.70003627093372 0.999351232383564 0.134471239533406 0.101807203885816 0.173188298207655 0.657999282456383 NA NA NA 0.703989654723054 99.482402686627 a7635 gain_cnaBRCA64_(SDHC) 310 YM201636 FYV1 8 41 1.63315443905142 NA 2.26741743831108 2.44339919999229 -0.175981761681211 1.03486859369659 1.02020451646024 0.172125823469758 0.170052277896074 0.172496552251902 0.658123582754942 NA NA NA 0.668752256497231 99.482402686627 a7636 ARID1A_mut 302 PI-103 PI3Ka, PRKDC (DNAPK) 5 43 2.32630161961136 NA 0.777072556613011 1.16928904345029 -0.392216486837278 1.79776264508487 1.87022206195905 0.210412838145826 0.218169227127734 0.209716533033747 0.658178225665161 NA NA NA 0.664753119306583 99.482402686627 a7637 gain_cnaBRCA12_(TERT) 193 GW-2580 CSF1R (cFMS) 9 39 2.99573227355399 NA 5.56366983040871 5.44024710686308 0.123422723545625 0.643091630674301 0.770401063101735 0.164604314875835 0.191920898451458 0.160205806374032 0.658322858838384 NA NA NA 0.625588525325057 99.482402686627 a7638 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1031 Elesclomol HSP70 6 38 -1.6094379124341 NA -3.28092928277176 -2.92968166864427 -0.351247614127494 1.3646127920998 1.84643500872116 0.19558668424244 0.257397275007961 0.190230152953375 0.65844291044727 NA NA NA 0.593473080822086 99.482402686627 a7639 gain_cnaBRCA8_(CHD4,WNK1) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 3 40 1.6094379124341 NA 3.32144650802171 2.91774110412939 0.403705403892323 1.04652148941283 1.53466074227454 0.26655954350574 0.385759306403568 0.263058402923623 0.658446841849639 NA NA NA 0.5837044967922 99.482402686627 a7640 gain_cnaBRCA9_(KRAS) 157 JNK-9L JNK 4 43 1.63315443905142 NA -0.170053657543398 0.0768580611161925 -0.246911718659591 1.69070679905507 1.00166390896452 0.232583141724072 0.146040530976505 0.246501562499979 0.658501846072644 NA NA NA 0.791410387847709 99.482402686627 a7641 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 3 Rapamycin MTOR 3 11 -2.30258509299405 NA -2.11471532098499 -2.9133767200241 0.798661399039109 0.628566179766331 2.95107290064734 0.295129071300752 1.27060829034106 0.270634249280632 0.658552498102024 NA NA NA 0.422199992072143 99.482402686627 a7642 loss_cnaBRCA60 1129 PF-4708671 RPS6KB1 (p70S6KA) 3 40 2.30258509299405 NA 3.52348710087586 3.83037791003176 -0.306890809155903 0.507626979665019 1.17543464940044 0.266426858661972 0.604559689397161 0.261087087497752 0.658605692755148 NA NA NA 0.427678847811775 99.482402686627 a7643 gain_cnaBRCA27_(CLTC,PPM1D) 140 Vinorelbine Microtubules 9 38 -2.74887219562247 NA -3.82049697977424 -3.5475508321391 -0.272946147635134 1.4413203112476 1.69813261444761 0.164883139497508 0.189372303647669 0.160733116667641 0.658614373987558 NA NA NA 0.629866968216104 99.482402686627 a7644 gain_cnaBRCA31 1030 KU-55933 ATM 13 29 2.30258509299405 NA 4.3174945774176 4.17962563467526 0.13786894274234 1.01243299749859 0.889424550483232 0.148559168250168 0.13617586850979 0.155009149081206 0.658655848633714 NA NA NA 0.676511629261495 99.482402686627 a7645 loss_cnaBRCA38 1043 JNK Inhibitor VIII JNK 3 40 2.30258509299405 NA 4.9832676819247 4.78338594362034 0.199881738304352 0.132080373600754 0.768936682568402 0.266326174458138 1.51333413780722 0.259945640305139 0.658726243009346 NA NA NA 0.179908302022444 99.482402686627 a7646 gain_cnaBRCA13_(FGFR1,WHSC1L1) 287 KIN001-244 PDPK1 (PDK1) 11 38 2.99573227355399 NA 3.36626073587947 3.51048231464021 -0.144221578760733 1.15024058697518 0.885145766179302 0.152167923588807 0.125383837428305 0.162935399197874 0.658764290273307 NA NA NA 0.706748747246516 99.482402686627 a7647 MLL3_mut 1008 Methotrexate Dihydrofolate reductase (DHFR) 3 42 -1.6094379124341 NA 0.954487277540805 0.663233131370509 0.291254146170296 0.877561736388025 1.10547304877777 0.265761258849459 0.331890206800805 0.263465623600964 0.658764353254689 NA NA NA 0.631022043266091 99.482402686627 a7648 PIK3CA_mut 1264 SGC0946 Q8TEK3 (DOT1L) 16 30 -0.693147180559945 NA 2.00548888932673 1.92150020945145 0.0839886798752822 0.598656432637704 0.616385954421674 0.137596211012232 0.140295293421011 0.136259885989915 0.658877219544314 NA NA NA 0.656836890053525 99.482402686627 a7649 PTEN_mut 173 FH535 unknown 8 40 3.46573590279973 NA 1.38844590773894 1.60990850268893 -0.221462594949992 0.861102125878768 1.34940152399024 0.172063061009035 0.257185051917026 0.164119123191085 0.658934180422704 NA NA NA 0.560301360469275 99.482402686627 a7650 gain_cnaBRCA62 1377 Afatinib (rescreen) ERBB2, EGFR 8 39 2.30258509299405 NA 2.54858160080431 2.89331880265878 -0.344737201854472 2.73035452433998 1.83290061491738 0.172442485349712 0.126260966765042 0.188082866604314 0.658957834716977 NA NA NA 0.741043893104645 99.482402686627 a7651 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 345 KIN001-270 CDK9 15 34 2.99573227355399 NA 5.04131283139692 5.13682558675595 -0.095512755359028 0.657521495476366 0.708874639651503 0.137631316815619 0.145261799068379 0.134738570145469 0.65906448418989 NA NA NA 0.650802966973159 99.482402686627 a7652 gain_cnaBRCA10_(MDM2,NUP107) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 44 2.99573227355399 NA 3.49162255494817 3.87193780110085 -0.38031524615268 1.65326627802251 1.4245811778439 0.26493227213346 0.230038712582694 0.266966356194798 0.659177782996718 NA NA NA 0.731813536466279 99.482402686627 a7653 loss_cnaBRCA34 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 5 43 2.77258872223978 NA -0.170552922463321 -0.46745444329137 0.296901520828049 0.844934777396383 1.45826181348997 0.209747590532781 0.351389869100824 0.203599599249941 0.659188400425839 NA NA NA 0.519549265846242 99.482402686627 a7654 loss_cnaBRCA20 1069 EHT 1864 Rac GTPases 3 43 2.30258509299405 NA 3.34735892664549 3.57635630432435 -0.228997377678863 0.712539216504972 0.870182055039693 0.265153450819226 0.321382139220494 0.263160308067278 0.659196396006492 NA NA NA 0.640658953913997 99.482402686627 a7655 MLL3_mut 1046 681640 WEE1, CHEK1 3 33 0.693147180559945 NA 2.3696079193188 2.65781188035387 -0.288203961035076 1.72352253142115 1.02002335999975 0.268287504476777 0.167217982811884 0.282546432108326 0.659208346347729 NA NA NA 0.800910064518181 99.482402686627 a7656 gain_cnaBRCA10_(MDM2,NUP107) 164 JQ12 HDAC 4 43 1.63315443905142 NA 1.9281975961348 1.54529578295157 0.382901813183237 2.05688500694529 1.61763395275518 0.231983239007783 0.186156159381943 0.236704856825658 0.659325206649158 NA NA NA 0.738946031721257 99.482402686627 a7657 gain_cnaBRCA63 1010 Gefitinib EGFR 6 39 -0.693147180559945 NA 1.57662817554585 1.37270852839144 0.203919647154404 1.39056673226875 0.993857937244872 0.19462939145394 0.14664499187443 0.205179874821648 0.659395766558261 NA NA NA 0.741613556020434 99.482402686627 a7658 gain_cnaBRCA9_(KRAS) 1373 Dabrafenib BRAF 4 42 2.30258509299405 NA 4.56321547083507 4.18138662303023 0.381828847804842 0.604827006634184 1.69561588413592 0.232200636041491 0.631302576797438 0.225185934725671 0.65939739831449 NA NA NA 0.365118230102266 99.482402686627 a7659 NF1_mut 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 4 44 2.32630161961136 NA 5.10705634938827 4.94498440839435 0.162071940993918 0.24890716855488 0.720642806279223 0.231650156251127 0.651134083180027 0.224899131139209 0.659428422720206 NA NA NA 0.352334711161872 99.482402686627 a7660 PIK3CA_mut 1133 JNJ-26854165 MDM2 15 28 2.30258509299405 NA 3.04998691729623 2.92533124346445 0.124655673831777 0.868597144124818 0.882316022998958 0.1420325562111 0.143513796556835 0.141282341680793 0.659453915486488 NA NA NA 0.658856589148022 99.482402686627 a7661 loss_cnaBRCA7_(FAS,PTEN) 1218 JQ1 BRD2, BRD3, BRD4 4 42 0 NA 2.30833075050926 2.47223435976904 -0.163903609259776 1.07184642915638 0.671511849130333 0.232139907835954 0.152917064237252 0.244081484894191 0.659480673673324 NA NA NA 0.782279178873793 99.482402686627 a7662 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1133 JNJ-26854165 MDM2 17 26 2.30258509299405 NA 3.04225704562197 2.92079649234133 0.121460553280641 0.822272759775368 0.911338999865332 0.13839174758036 0.147713215398042 0.133277027866238 0.659594041311118 NA NA NA 0.652813751776144 99.482402686627 a7663 gain_cnaBRCA27_(CLTC,PPM1D) 1 Erlotinib EGFR 3 9 0.693147180559945 NA 3.05912571087693 2.88238822245871 0.176737488418222 0.306488473954733 0.634803052795922 0.302583463765457 0.57665296883016 0.278413104095515 0.659609768085342 NA NA NA 0.540028159398646 99.482402686627 a7664 POLR2B_mut 171 AKT inhibitor VIII AKT1, AKT2, AKT3 3 44 0.940007258491471 NA 2.2006534280933 1.86738633407711 0.333267094016191 1.4211045823899 1.25231636995597 0.264435116095588 0.234512715071068 0.26612052833575 0.659775752101896 NA NA NA 0.727106042752546 99.482402686627 a7665 loss_cnaBRCA17 229 LY317615 PRKCB (PKCbeta) 11 38 2.99573227355399 2.32630161961136 3.16772533042243 3.41383136562184 -0.246106035199408 1.63027760981763 1.62037287507058 0.151684598162364 0.150959587322639 0.151882346949734 0.659777699995602 NA NA NA 0.664686342192521 99.482402686627 a7666 TP53_mut 207 AS601245 JNK 38 10 2.07944154167984 NA 2.30852205116777 2.10537962868483 0.203142422482941 1.2900028474835 1.29226016849472 0.157420465587891 0.157474398509449 0.157199322114501 0.659894399753013 NA NA NA 0.664862270013085 99.482402686627 a7667 gain_cnaBRCA27_(CLTC,PPM1D) 277 ABT-869 VEGFR and PDGFR family 9 39 0.0237165266173161 NA 2.62746465700424 2.70575830736789 -0.0782936503636549 0.365056246690256 0.498557132279314 0.163785562889325 0.214470101726778 0.157040478000405 0.659911839276504 NA NA NA 0.598117316412182 99.482402686627 a7668 gain_cnaBRCA9_(KRAS) 1047 Nutlin-3a MDM2 4 39 2.07944154167984 1.38629436111989 4.42036679125478 4.18505510926922 0.235311681985557 0.805820246139333 1.02575009896271 0.232686789460733 0.292015102763836 0.229404493573548 0.659950912072397 NA NA NA 0.616867949782027 99.482402686627 a7669 gain_cnaBRCA10_(MDM2,NUP107) 261 TL-1-85 MAP3K7 (TAK1) 5 44 2.32630161961136 NA 4.25337723857615 3.99883251450709 0.254544724069061 0.839507008237987 1.2478103513008 0.208917244138915 0.303207384299646 0.203993117867396 0.660029617573102 NA NA NA 0.565846552437749 99.482402686627 a7670 NF1_mut 164 JQ12 HDAC 4 43 1.63315443905142 NA 1.22838350822941 1.610394767873 -0.382011259643589 1.38933180255675 1.6676698565929 0.231441339002778 0.274960422658277 0.229068876032843 0.660069326075467 NA NA NA 0.633789992286875 99.482402686627 a7671 gain_cnaBRCA61_(NOTCH2) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 3 44 0.940007258491471 NA 1.57701240518664 1.90990731291165 -0.332894907725009 1.98306949598256 1.21627896163392 0.264138513393257 0.167868503045107 0.273699470455204 0.660132606823084 NA NA NA 0.799861549666064 99.482402686627 a7672 loss_cnaBRCA28_(GPS2) 1009 ATRA Retinoic acid and retinoid X receptor agonist 3 42 2.30258509299405 NA 3.81847268758535 4.12650645615728 -0.308033768571923 1.26100905075433 1.15917149405471 0.264609795868657 0.244275620692539 0.265736148750897 0.660146621413087 NA NA NA 0.717058974075459 99.482402686627 a7673 loss_cnaBRCA7_(FAS,PTEN) 282 EKB-569 EGFR 4 43 0.916290731874155 2.99573227355399 2.02842388232599 1.5361738306407 0.492250051685297 1.0166735929109 2.18548174191251 0.231360552533845 0.484177080154021 0.225236405431843 0.660180289217936 NA NA NA 0.448697973098926 99.482402686627 a7674 loss_cnaBRCA36_(FAT1,IRF2) 294 MPS-1-IN-1 MPS1 9 40 2.99573227355399 NA 4.599458932088 4.79185592639908 -0.192396994311083 1.14169108043898 1.1860613855417 0.163238243206121 0.168519311053132 0.162215039336443 0.660185131843485 NA NA NA 0.658152498177486 99.482402686627 a7675 PIK3CA_mut 1 Erlotinib EGFR 3 9 0.693147180559945 NA 3.05879585601086 2.88249817408073 0.176297681930131 0.306012878283444 0.634894802684099 0.301815040587947 0.5761119692709 0.277680146671244 0.660411830955142 NA NA NA 0.540763449464114 99.482402686627 a7676 loss_cnaBRCA22_(SYNCRIP,ZNF292) 155 AP-24534 ABL 17 30 -0.669430653942629 NA 1.5431441452836 1.3899486097712 0.153195535512403 1.21864255839048 1.09591517311785 0.134256639803045 0.125709983175653 0.139787767584754 0.660423647971329 NA NA NA 0.670784907516667 99.482402686627 a7677 gain_cnaBRCA9_(KRAS) 1058 GDC0941 PI3K (class 1) 4 39 1.38629436111989 0.693147180559945 1.05209267821219 1.37614717378475 -0.324054495572556 0.999138502912933 1.42157626344132 0.232295363645279 0.324333908289785 0.227954351733541 0.660485788447234 NA NA NA 0.584250986232958 99.482402686627 a7678 gain_cnaBRCA8_(CHD4,WNK1) 1268 XAV 939 TNKS1 (tankyrase-1) 3 44 1.6094379124341 NA 3.42816009528218 3.67734831693709 -0.249188221654912 1.07515569438144 0.937979062614856 0.263831124270122 0.231769429262312 0.265665014910073 0.660502523460482 NA NA NA 0.730012354177189 99.482402686627 a7679 ASH1L_mut 308 XL-880 MET 3 46 1.63315443905142 NA 1.44921455209145 1.87371929064809 -0.424504738556639 0.149049521364652 1.64805782120266 0.263192703954747 2.84807850887411 0.257578789466779 0.660740748365414 NA NA NA 0.107051866211797 99.482402686627 a7680 gain_cnaBRCA62 269 NSC-207895 MDM4 10 39 2.99573227355399 NA 4.45513822913778 4.64209731497119 -0.186959085833411 0.97492572090589 1.24057015298716 0.156544803804077 0.191767518103524 0.15070416242341 0.660771753367976 NA NA NA 0.616651553028839 99.482402686627 a7681 loss_cnaBRCA38 260 NG-25 MAP3K7 (TAK1) 4 45 2.32630161961136 NA 2.93512519085704 3.23262946812584 -0.297504277268796 0.681320624929788 1.3235083533442 0.230250537076805 0.436658258069694 0.224784585996055 0.661015780183843 NA NA NA 0.481981410831898 99.482402686627 a7682 NF1_mut 205 BMS-708163 g-secretase 4 44 2.32630161961136 0.940007258491471 5.04076641648792 4.88341707226796 0.157349344219963 0.498866139668454 0.693738762284657 0.230471736254745 0.315413959192614 0.226813539583361 0.661049019411792 NA NA NA 0.590949633062889 99.482402686627 a7683 gain_cnaBRCA27_(CLTC,PPM1D) 1004 Vinblastine Microtubules 10 35 -2.30258509299405 NA -3.29662161688887 -3.50097142386782 0.204349806978949 1.30820446469704 1.28614828884451 0.158313029595892 0.156206321330873 0.158885105824413 0.661053305498551 NA NA NA 0.668419491710752 99.482402686627 a7684 loss_cnaBRCA20 312 AV-951 VEGFR 3 45 -2.05572501506252 NA 0.473167918401422 0.642883043751212 -0.16971512534979 0.38747445525762 0.654437676822643 0.263070450685747 0.438003391054389 0.259329698396603 0.661147620845858 NA NA NA 0.539602067116343 99.482402686627 a7685 loss_cnaBRCA7_(FAS,PTEN) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 42 1.38629436111989 NA 3.17271665645498 2.82869425230368 0.344022404151299 0.787733632489661 1.52852318006093 0.230924305582433 0.436724280851135 0.225068490055601 0.661148521529561 NA NA NA 0.484516695238001 99.482402686627 a7686 loss_cnaBRCA23 172 Embelin XIAP 3 45 3.46573590279973 NA 2.75311104790973 3.0090589219224 -0.255947874012663 1.0238008338347 0.970721214959784 0.263026108501433 0.249997719824075 0.263667745247812 0.661201059664154 NA NA NA 0.710920238294384 99.482402686627 a7687 loss_cnaBRCA7_(FAS,PTEN) 300 CX-5461 RNA Pol I 4 45 2.32630161961136 NA 4.27501509950107 3.88012975488796 0.394885344613113 1.40297251166402 1.73649044494823 0.229967076302855 0.281463351085012 0.227404271507457 0.661406274104634 NA NA NA 0.626261674103507 99.482402686627 a7688 BRCA2_mut 294 MPS-1-IN-1 MPS1 6 43 2.99573227355399 NA 4.55794978181089 4.78422485474162 -0.226275072930735 1.3562327671408 1.15569116906315 0.19197843672287 0.166840883374147 0.195791989233735 0.661581044913164 NA NA NA 0.710287055289568 99.482402686627 a7689 gain_cnaBRCA31 266 Zibotentan, ZD4054 Endothelin A Receptor 16 33 2.99573227355399 NA 5.78677223042375 5.72035073193535 0.0664214984884 0.55315473308989 0.465386376080078 0.13416020439999 0.120077610323197 0.142723341082445 0.661669731915325 NA NA NA 0.682004179734011 99.482402686627 a7690 gain_cnaBRCA19 184 BMS-754807 IGF1R 4 44 0.940007258491471 NA 1.27104858473685 1.65921626103833 -0.388167676301485 1.66048364470929 1.68966501385622 0.229987502122569 0.233767840796435 0.229730551984144 0.661715428570182 NA NA NA 0.680522907429134 99.482402686627 a7691 loss_cnaBRCA57 1529 MLN4924 NEDD8-activating enzyme 3 34 0 NA -0.048751060922378 0.406094654697269 -0.454845715619647 2.62955742748597 1.6394754377249 0.265750688921502 0.172974246869561 0.27743368711326 0.661754050054873 NA NA NA 0.794455904086415 99.482402686627 a7692 BRCA1_mut 1050 ZM-447439 AURKB 3 36 1.38629436111989 0.693147180559945 3.21225731673383 2.86089631196118 0.351361004772646 0.834993488276136 1.34864532294895 0.264982688134582 0.420794904039359 0.260528842382636 0.661809456523825 NA NA NA 0.556728065053421 99.482402686627 a7693 loss_cnaBRCA42 177 GSK-650394 SGK3 3 44 2.77258872223978 NA 4.43383794520132 3.98584341573576 0.447994529465559 0.871657228762808 1.73446260398504 0.262690192563076 0.513957223875057 0.258290105786232 0.661876286937584 NA NA NA 0.483704840041156 99.482402686627 a7694 gain_cnaBRCA31 1023 GW 441756 NTRK1 14 31 0.693147180559945 NA 2.48716564446434 2.30153505057295 0.18563059389139 1.37331630070406 1.28054858665493 0.141779800251046 0.135169584600593 0.144961773278981 0.661922186496863 NA NA NA 0.672117938410749 99.482402686627 a7695 gain_cnaBRCA64_(SDHC) 303 PIK-93 PI4K, PI3K 8 41 2.99573227355399 NA 2.58808794593821 2.83122266380991 -0.243134717871699 0.927811880313472 1.5001963138068 0.170078168523385 0.26205174026178 0.16206860104511 0.661928595975093 NA NA NA 0.555264142488863 99.482402686627 a7696 gain_cnaBRCA63 1042 BIRB 0796 p38, JNK2 5 38 2.30258509299405 NA 4.53863613489646 4.34395863614975 0.194677498746702 0.712664836747583 0.949965521343495 0.209446616173492 0.273168379732554 0.204931120522541 0.662056343855237 NA NA NA 0.602063574962296 99.482402686627 a7697 loss_cnaBRCA20 300 CX-5461 RNA Pol I 3 46 2.32630161961136 NA 4.33463748762261 3.88482580228467 0.449811685337944 1.08323271259963 1.73997930853732 0.261951381923825 0.415249355107129 0.258515537012949 0.662238308956906 NA NA NA 0.557718697879744 99.482402686627 a7698 loss_cnaBRCA42 175 PAC-1 CASP3 agonist 3 45 0.940007258491471 NA 2.09928270290174 2.4215217403872 -0.322239037485455 0.904692003057528 1.24208644737631 0.262122731436941 0.356186455054764 0.259433663547435 0.662290149130581 NA NA NA 0.608563156469057 99.482402686627 a7699 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1019 Bosutinib SRC, ABL, TEC 8 37 0.693147180559945 NA 2.53014689375685 2.69123673051066 -0.161089836753813 1.29397503551585 0.853734202772479 0.171451526263248 0.124492229241188 0.188688512455842 0.662338653748947 NA NA NA 0.744684761898288 99.482402686627 a7700 loss_cnaBRCA20 1219 PFI-1 BRD2, BRD3, BRD4 3 44 2.30258509299405 NA 3.41887280032 3.15568162576314 0.263191174556861 0.764618684006437 1.01325156415975 0.262270562638419 0.344212324472371 0.259749092788341 0.662381847810944 NA NA NA 0.619557595236761 99.482402686627 a7701 gain_cnaBRCA14_(RAD21) 238 CAL-101 PI3Kdelta 21 28 2.99573227355399 2.32630161961136 4.78785481873313 4.66729626995619 0.120558548776935 0.845547821483877 1.02137312407421 0.12683198637691 0.142580402567135 0.118035755920454 0.662415016065451 NA NA NA 0.653737763108249 99.482402686627 a7702 ASH1L_mut 196 Phenformin AAPK1 (AMPK) agonist 3 45 8.29404964010203 NA 7.64915780695473 7.17220343585683 0.476954371097901 1.58455371657968 1.83154680795303 0.261846380728127 0.301002336561632 0.260410691677027 0.662623458391093 NA NA NA 0.659943461871959 99.482402686627 a7703 gain_cnaBRCA15 1248 FK866 NAMPT 21 23 0 NA -0.461490603991729 -0.823467635316631 0.361977031324902 2.72379425427098 2.73599331131158 0.132583041531015 0.132894410345903 0.13230186997474 0.662715067485236 NA NA NA 0.662667068892611 99.482402686627 a7704 gain_cnaBRCA31 268 YM155 BIRC5 (Survivin) 16 33 1.63315443905142 NA -3.74011539681419 -3.52549926508596 -0.214616131728229 1.53979292994112 1.63735445391506 0.133562309219796 0.139379865665726 0.131074936899009 0.66308143031625 NA NA NA 0.657171088164709 99.482402686627 a7705 gain_cnaBRCA19 1031 Elesclomol HSP70 4 40 -1.6094379124341 NA -3.3531550552357 -2.94002147210425 -0.413133583131456 1.56440890631148 1.81257920524995 0.23003106969895 0.264082863159818 0.227925809771434 0.663161926987999 NA NA NA 0.646888530004895 99.482402686627 a7706 NF1_mut 1054 PD-0332991 CDK4, CDK6 4 38 1.38629436111989 0.693147180559945 3.19064626607826 2.85051089328809 0.340135372790169 1.83654323498159 1.44147881165737 0.230633997277176 0.185204119517273 0.235962797399076 0.663201082599642 NA NA NA 0.740781989813039 99.482402686627 a7707 gain_cnaBRCA31 1042 BIRB 0796 p38, JNK2 13 30 2.30258509299405 NA 4.27217293667441 4.40751202238019 -0.135339085705777 1.14708631696772 0.822806192431292 0.145603779961696 0.117985092929659 0.164484768042236 0.663325022937673 NA NA NA 0.705091301768135 99.482402686627 a7708 gain_cnaBRCA15 186 Bexarotene Retinioic acid X family agonist 21 26 2.07944154167984 NA 3.52286796321502 3.67026267297111 -0.147394709756095 1.40043428696794 0.892842603082674 0.128557627923774 0.105249286687502 0.16508476325748 0.663357431038446 NA NA NA 0.678345667206749 99.482402686627 a7709 gain_cnaBRCA31 203 BMS-345541 IKBKB 16 33 2.77258872223978 NA 3.62337500330541 3.48819015374383 0.13518484956158 0.915511046601757 1.05647990020197 0.1333680942309 0.14766053349478 0.127957805478113 0.663540260141251 NA NA NA 0.648147076135306 99.482402686627 a7710 MLL3_mut 1199 Tamoxifen ER 3 44 1.6094379124341 NA 3.63471780689915 3.88515561425203 -0.250437807352882 1.13588723327499 0.949400033173948 0.26129210215648 0.22047770237792 0.263785336635855 0.663561292982067 NA NA NA 0.74206503651851 99.482402686627 a7711 loss_cnaBRCA7_(FAS,PTEN) 266 Zibotentan, ZD4054 Endothelin A Receptor 4 45 2.99573227355399 NA 5.8458441664791 5.73281229277178 0.113031873707321 0.351799431376714 0.503391311667735 0.228299277004974 0.321296351347095 0.22454077193515 0.663705747867691 NA NA NA 0.584957701495812 99.482402686627 a7712 loss_cnaBRCA18 1028 VX-702 p38 14 31 0.693147180559945 NA 3.36007881298376 3.45697777578856 -0.0968989628047945 0.7103775267407 0.677782281154885 0.140882554765197 0.136404882132715 0.142964732922328 0.663925532533713 NA NA NA 0.671266224061098 99.482402686627 a7713 loss_cnaBRCA36_(FAT1,IRF2) 276 CAY10603 HDAC6 9 40 2.99573227355399 NA 1.04423189043942 1.20508401275743 -0.160852122318005 0.868036218406569 1.02159453373158 0.161315358757922 0.18530577285505 0.157452019374516 0.663933293634157 NA NA NA 0.635176975009722 99.482402686627 a7714 NF1_mut 228 KIN001-102 AKT1 5 44 2.32630161961136 NA 1.68174673937134 1.97347142059475 -0.29172468122341 1.2512661316796 1.42854565035406 0.20626447951444 0.23314359258795 0.20421096179258 0.664071852461459 NA NA NA 0.646177466745657 99.482402686627 a7715 CDH1_mut 231 FMK RSK 4 45 2.99573227355399 2.32630161961136 5.46429883857626 5.60033466259339 -0.136035824017131 0.377306808240047 0.60868573967918 0.228016948295896 0.360544313132519 0.223491064681146 0.664095332329295 NA NA NA 0.547284655277994 99.482402686627 a7716 BRCA1_mut 291 KIN001-266 MAP3K8 (COT) 4 45 2.99573227355399 NA 3.53023510208173 3.80071434735111 -0.270479245269378 0.78855115577477 1.20861466649143 0.228011100293268 0.343007861048184 0.22379278753465 0.664103402960043 NA NA NA 0.563756314617673 99.482402686627 a7717 loss_cnaBRCA38 171 AKT inhibitor VIII AKT1, AKT2, AKT3 4 43 0.940007258491471 NA 1.62523676887944 1.91316306763151 -0.287926298752072 1.94251574051546 1.1968635904119 0.228445211278118 0.148223405734498 0.240567347071676 0.664189768877357 NA NA NA 0.788581222446362 99.482402686627 a7718 loss_cnaBRCA24 190 Bleomycin DNA damage 3 45 4.15888308335967 NA 1.40463481505304 2.12331677908118 -0.718681964028141 2.54746182431981 2.76784636554649 0.260521279973381 0.282116873025186 0.259653849640691 0.664222633215662 NA NA NA 0.6784946830518 99.482402686627 a7719 loss_cnaBRCA34 288 KIN001-055 JAK3, MNK1 5 44 2.32630161961136 NA 4.17986797629246 4.35709096841304 -0.177222992120579 0.753817647440768 0.869061878354839 0.206107900811198 0.235100614481839 0.203924480562958 0.664310761368084 NA NA NA 0.643789728371719 99.482402686627 a7720 loss_cnaBRCA60 1230 IOX2 EGLN1 3 44 -2.30258509299405 NA 0.0890329007362977 0.260401108552895 -0.171368207816597 0.339608271815866 0.668612280136801 0.260638008940378 0.504605517705152 0.256304308053592 0.66435022397527 NA NA NA 0.490597087413426 99.482402686627 a7721 POLR2B_mut 163 JQ1 BRD4 3 44 0.940007258491471 NA 0.67361776416691 0.291528038703669 0.382089725463242 0.419513755302075 1.49742726498504 0.260555581641808 0.910791888547526 0.255164130103548 0.664449670518135 NA NA NA 0.287728041199492 99.482402686627 a7722 MACF1_mut 1059 AZD8055 MTORC1/2 3 40 0.693147180559945 NA -0.11625450452241 0.148932126512154 -0.265186631034564 1.38197462127135 0.991380191715824 0.26154319415582 0.191889653364694 0.267492363929114 0.664463502311434 NA NA NA 0.773275033179694 99.482402686627 a7723 loss_cnaBRCA17 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 11 37 2.77258872223978 NA -0.600029337536695 -0.387918458403834 -0.212110879132861 1.42236991430978 1.41374018830947 0.149835955710664 0.14912497585819 0.150035261702859 0.664654687853448 NA NA NA 0.669365026415576 99.482402686627 a7724 BRCA2_mut 1021 Axitinib PDGFR, KIT, VEGFR 5 40 0.693147180559945 NA 2.24569554392548 2.48943390021005 -0.243738356284564 1.18855825180269 1.17611884910887 0.207034890501674 0.205070602063369 0.207239562965291 0.664681109412846 NA NA NA 0.683065701997847 99.482402686627 a7725 NF1_mut 157 JNK-9L JNK 4 43 1.63315443905142 NA -0.165541459952672 0.0764383218054272 -0.241979781758099 0.562505536106576 1.08863107070947 0.227917584227732 0.43018204484347 0.222278959574797 0.664916483628229 NA NA NA 0.48964833337371 99.482402686627 a7726 gain_cnaBRCA15 175 PAC-1 CASP3 agonist 22 26 0.940007258491471 NA 2.31729696729096 2.47253050560493 -0.155233538313968 1.10480581344713 1.32501425500838 0.126269028149343 0.140507532115187 0.117156126982941 0.664957279654511 NA NA NA 0.66012302390097 99.482402686627 a7727 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1129 PF-4708671 RPS6KB1 (p70S6KA) 5 38 2.30258509299405 NA 3.59772665723149 3.8367616952037 -0.239035037972209 2.01054658878771 1.0166287985516 0.207498193293041 0.118890573988807 0.235125188576956 0.665000767755094 NA NA NA 0.805842909513605 99.482402686627 a7728 gain_cnaBRCA63 110 Roscovitine CDKs 3 10 2.77258872223978 NA 3.84416190316751 4.15078258558882 -0.306620682421307 1.02012842766358 1.05282583680612 0.292868511139356 0.300570667483079 0.291235902180629 0.665019867076343 NA NA NA 0.677747194275372 99.482402686627 a7729 gain_cnaBRCA48 1230 IOX2 EGLN1 5 42 -2.30258509299405 NA 0.370604863339813 0.23504102766279 0.135563835677023 0.457372778097429 0.673851249200667 0.206180346896974 0.296396817145391 0.201177686971466 0.66505031586227 NA NA NA 0.575238627147162 99.482402686627 a7730 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1058 GDC0941 PI3K (class 1) 16 27 1.38629436111989 0.693147180559945 1.46651415451555 1.27458829697056 0.191925857544989 1.08859864898008 1.54451181469333 0.13757081521469 0.176305434261568 0.124263120371855 0.665089600461833 NA NA NA 0.636527045268733 99.482402686627 a7731 loss_cnaBRCA20 1061 SB590885 BRAF 3 39 1.6094379124341 NA 4.27751399370317 3.99148075046955 0.286033243233627 0.565902946780782 1.11571354901119 0.261265167586419 0.505445756840051 0.25636799291998 0.665135123447319 NA NA NA 0.492818763904492 99.482402686627 a7732 gain_cnaBRCA14_(RAD21) 152 CP466722 ATM 21 28 2.77258872223978 NA 2.65349951532579 2.78762344469083 -0.13412392936504 0.805674729469316 1.22525203867542 0.125693913782052 0.166474042760886 0.109466399672379 0.665253266777891 NA NA NA 0.646721149600083 99.482402686627 a7733 gain_cnaBRCA64_(SDHC) 306 TG101348 JAK2 8 40 2.32630161961136 NA 3.40614629123587 3.18863745974137 0.217508831494502 1.50116711094549 1.24859667046349 0.16858213117375 0.144893150075416 0.17420263615933 0.665396812541451 NA NA NA 0.709777703068749 99.482402686627 a7734 gain_cnaBRCA13_(FGFR1,WHSC1L1) 151 QS11 ARFGAP 10 38 2.32630161961136 NA 3.5781423110025 3.8084255721643 -0.2302832611618 1.29542557526815 1.53235839546146 0.154659274445052 0.177766492771405 0.150280288112659 0.665482564036921 NA NA NA 0.637193330293998 99.482402686627 a7735 NF1_mut 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 3 23 2.30258509299405 NA 4.9242713154747 4.654685743464 0.269585572010699 0.905610406105621 1.01181082680505 0.268674709584258 0.297683827607494 0.266438710546277 0.665526202118189 NA NA NA 0.66858470392312 99.482402686627 a7736 gain_cnaBRCA62 281 CH5424802 ALK 10 38 1.63315443905142 NA 3.70630226521926 3.54074945784417 0.165552807375088 1.00385268748903 1.08653097105343 0.154598399565067 0.164917432047914 0.15236823595979 0.66560598202909 NA NA NA 0.654935204463827 99.482402686627 a7737 gain_cnaBRCA48 1219 PFI-1 BRD2, BRD3, BRD4 5 42 2.30258509299405 NA 3.35700021434468 3.15051449673368 0.206485717611006 0.923162606340097 1.01105588016902 0.205754279858886 0.223672098710349 0.204227799532194 0.665699070006252 NA NA NA 0.658795440556495 99.482402686627 a7738 gain_cnaBRCA9_(KRAS) 193 GW-2580 CSF1R (cFMS) 4 44 2.99573227355399 NA 5.61944294372505 5.44920213332814 0.17024081039691 0.763499865423739 0.748930095964062 0.227021368391326 0.222974250692798 0.227312016587833 0.665803485674097 NA NA NA 0.693586007762897 99.482402686627 a7739 ASH1L_mut 312 AV-951 VEGFR 3 45 -2.05572501506252 NA 0.475533641705519 0.642725328864273 -0.167191687158754 0.578237090458122 0.648050386148983 0.25914276083892 0.289140371514896 0.257991802384819 0.665887952509866 NA NA NA 0.671627719850952 99.482402686627 a7740 gain_cnaBRCA58_(CCND1) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 8 38 1.63315443905142 NA 2.1601927327624 1.88952176141417 0.270670971348237 1.21821073016371 1.66396614588917 0.169024430158815 0.222187315089453 0.162666152804208 0.666036219550998 NA NA NA 0.603230093671126 99.482402686627 a7741 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1052 RO-3306 CDK1 4 39 1.6094379124341 NA 3.27548427429741 3.55133377976578 -0.275849505468371 1.05469367939943 1.21999668422245 0.228226002526332 0.261544665390853 0.226106766547632 0.666057111048304 NA NA NA 0.650250049375914 99.482402686627 a7742 gain_cnaBRCA8_(CHD4,WNK1) 226 GSK1070916 AURKB 4 45 0.940007258491471 2.32630161961136 1.99646774487062 2.44016815048379 -0.443700405613169 3.27644449562212 1.83435595110601 0.226563557691981 0.135421309961462 0.241883482508204 0.666102342291244 NA NA NA 0.805805044629275 99.482402686627 a7743 gain_cnaBRCA31 277 ABT-869 VEGFR and PDGFR family 16 32 0.0237165266173161 NA 2.73343781886973 2.6698984624522 0.0635393564175359 0.439817637120957 0.495513620753127 0.132909343766556 0.144467504380825 0.128229283225278 0.666259537521447 NA NA NA 0.654193946803479 99.482402686627 a7744 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1049 PD-173074 FGFR1, FGFR3 5 38 0.693147180559945 NA 3.14769767356945 2.91014113678471 0.237556536784743 0.567343725154036 1.1959265618899 0.206601560677047 0.418717130819144 0.19863806387019 0.666357549926101 NA NA NA 0.474670836587506 99.482402686627 a7745 gain_cnaBRCA61_(NOTCH2) 300 CX-5461 RNA Pol I 3 46 2.32630161961136 NA 4.32895755886856 3.8851962324208 0.443761326447756 0.921605359030336 1.74420984576618 0.258413712240926 0.481509056017922 0.254419688963987 0.666513876253287 NA NA NA 0.506654001468596 99.482402686627 a7746 loss_cnaBRCA42 222 BX-912 PDPK1 (PDK1) 3 46 2.32630161961136 NA 4.25228651330506 3.85974779725447 0.392538716050589 0.867287860878785 1.54255412046952 0.258258822008964 0.452604877523417 0.254473221290354 0.66670133103993 NA NA NA 0.528437825785627 99.482402686627 a7747 gain_cnaBRCA19 1243 piperlongumine Increases ROS levels 4 43 2.30258509299405 NA 1.53229941377368 1.7268004525766 -0.19450103880292 0.512501136281335 0.877890506679119 0.2265898234847 0.37951338062234 0.221555008652135 0.66674668314628 NA NA NA 0.531909511678969 99.482402686627 a7748 loss_cnaBRCA29_(MAP2K4) 1149 TW 37 BCL2, BCL2L1 7 36 1.6094379124341 NA 0.045812499108977 -0.178978053138982 0.224790552247959 0.887252470438803 1.30744211228376 0.179148651052795 0.253355791882761 0.171931552560525 0.666786946099004 NA NA NA 0.584603687267061 99.482402686627 a7749 loss_cnaBRCA20 1025 SB 216763 GSK3A, GSK3B 3 36 2.30258509299405 NA 5.07984341668281 4.87327115962452 0.206572257058288 0.425852383309472 0.808058369967796 0.260781569910428 0.485079490345764 0.255640266515054 0.666832656103869 NA NA NA 0.509262876881001 99.482402686627 a7750 gain_cnaBRCA16 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 14 28 1.38629436111989 0.693147180559945 3.33402817488051 3.4831305974058 -0.149102422525293 1.20992558956186 0.964950144664615 0.141887434136249 0.12323272093062 0.154518265373302 0.666999791063157 NA NA NA 0.691913000951881 99.482402686627 a7751 CDH1_mut 1495 AZD-2281 PARP1, PARP2 5 40 2.30258509299405 NA 4.20629873021779 3.97274036779751 0.233558362420272 1.22065348672837 1.12759682681152 0.20549318923606 0.191338791032549 0.207129318624193 0.667022109179056 NA NA NA 0.701401643753123 99.482402686627 a7752 loss_cnaBRCA18 1219 PFI-1 BRD2, BRD3, BRD4 15 32 2.30258509299405 NA 3.07995433542317 3.2158529657247 -0.135898630301536 1.20587513632136 0.897388894923017 0.135414412257766 0.112697099565473 0.151437833775728 0.667263798121447 NA NA NA 0.701161931778077 99.482402686627 a7753 loss_cnaBRCA28_(GPS2) 1066 AZD6482 PI3Kbeta 4 39 1.6094379124341 NA 2.26550621578102 1.93659086076913 0.328915355011888 1.30362378359915 1.45812656111525 0.227248661205063 0.252308495096486 0.225573941098993 0.667398045363082 NA NA NA 0.660661818275757 99.482402686627 a7754 loss_cnaBRCA20 1009 ATRA Retinoic acid and retinoid X receptor agonist 3 42 2.30258509299405 NA 3.82508321410501 4.12603427569159 -0.30095106158658 1.06243235116179 1.16896515042755 0.258498761957015 0.283266093372895 0.257450841435698 0.667502595504119 NA NA NA 0.677838869735913 99.482402686627 a7755 POLR2B_mut 1149 TW 37 BCL2, BCL2L1 3 40 1.6094379124341 NA 0.159516400972205 -0.165026790553928 0.324543191526133 1.47254889786454 1.24259722221714 0.258642928334249 0.220395527779607 0.261181327081238 0.667952399355641 NA NA NA 0.742496928241941 99.482402686627 a7756 POLR2B_mut 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 3 45 2.77258872223978 NA -0.778088012474576 -0.413756480809373 -0.364331531665203 1.74187165640378 1.39905079670692 0.257353827467473 0.20916095070827 0.260413369209157 0.668051611071873 NA NA NA 0.754260183729006 99.482402686627 a7757 gain_cnaBRCA58_(CCND1) 1166 QL-VIII-58 MTOR, ATR 5 21 2.30258509299405 NA -1.71679655847202 -1.47193910089441 -0.244857457577613 0.914554401264192 1.17275828238295 0.215958901716144 0.267734163478024 0.208787660045412 0.668172650483884 NA NA NA 0.626350839450258 99.482402686627 a7758 loss_cnaBRCA29_(MAP2K4) 1017 Olaparib PARP1, PARP2 6 39 1.6094379124341 NA 3.92744222981681 4.09666053904871 -0.169218309231904 0.74096390625898 0.913020603902933 0.189130832993958 0.22837591386369 0.185338981955652 0.668415994917995 NA NA NA 0.628852057551976 99.482402686627 a7759 gain_cnaBRCA30_(CRNKL1,FOXA2) 294 MPS-1-IN-1 MPS1 5 44 2.99573227355399 NA 4.9717670872858 4.73205754564378 0.239709541642021 1.60640487344823 1.13077886904155 0.203358573358357 0.149221124514813 0.21198622312884 0.668511423046233 NA NA NA 0.760103341485317 99.482402686627 a7760 gain_cnaBRCA8_(CHD4,WNK1) 1031 Elesclomol HSP70 3 41 -1.6094379124341 NA -3.40917398681113 -2.94599895474828 -0.463175032062856 1.94765716234436 1.78821573581658 0.257874012425787 0.237811377185777 0.259015186359127 0.668560363084682 NA NA NA 0.724084408568249 99.482402686627 a7761 loss_cnaBRCA57 1043 JNK Inhibitor VIII JNK 5 38 2.30258509299405 NA 4.66128004481876 4.81523264648668 -0.153952601667925 0.283618179957981 0.784635970220855 0.205099277314109 0.542816407928199 0.196208952317839 0.668633338512253 NA NA NA 0.405496421371367 99.482402686627 a7762 loss_cnaBRCA34 1058 GDC0941 PI3K (class 1) 5 38 1.38629436111989 0.693147180559945 1.59885912491475 1.31273197015474 0.286127154760012 1.64050875823762 1.36601994088164 0.205082805651737 0.174413670956195 0.209460452367441 0.668658308766675 NA NA NA 0.724943359579282 99.482402686627 a7763 MACF1_mut 1020 Lenalidomide TNFA 3 42 1.6094379124341 NA 4.08303708817614 4.26699011179186 -0.183953023615724 1.01129396476198 0.696815799577239 0.257450353264848 0.181898666486178 0.2639908907452 0.668767942376175 NA NA NA 0.784295443786791 99.482402686627 a7764 loss_cnaBRCA42 219 AT-7519 CDK9 3 46 2.32630161961136 NA 1.23343615942666 1.70060252579714 -0.467166366370484 1.6334161693398 1.82988311213817 0.256409466057382 0.286005719264617 0.255298474132925 0.668941157379837 NA NA NA 0.674709477548633 99.482402686627 a7765 gain_cnaBRCA12_(TERT) 256 JW-7-24-1 LCK 9 39 2.32630161961136 NA 1.68626158595813 1.87248625387388 -0.186224667915753 0.872888113394239 1.22373073114225 0.15912631965878 0.213343113576854 0.15217781426632 0.668984200865691 NA NA NA 0.602714780855431 99.482402686627 a7766 loss_cnaBRCA33 152 CP466722 ATM 6 43 2.77258872223978 NA 2.55456668939122 2.75464060783343 -0.200073918442207 1.36184865573405 1.02640992980598 0.18748984697872 0.146913475003112 0.194925938099631 0.669002682412732 NA NA NA 0.741223751575376 99.482402686627 a7767 gain_cnaBRCA19 1018 ABT-888 PARP1, PARP2 4 41 1.6094379124341 NA 4.26577254381778 4.41647166989551 -0.150699126077733 0.737985050502338 0.662812737887542 0.225485512522631 0.204203494332512 0.227363050622756 0.669009927237297 NA NA NA 0.716973174109299 99.482402686627 a7768 loss_cnaBRCA38 1091 BMS-536924 IGF1R 3 44 1.38629436111989 NA 2.75872832160014 3.04134134857591 -0.282613026975773 0.368950001269018 1.12318963137093 0.256758039486707 0.765992752415542 0.251616484948161 0.669037909075535 NA NA NA 0.344619733263004 99.482402686627 a7769 gain_cnaBRCA14_(RAD21) 193 GW-2580 CSF1R (cFMS) 21 27 2.99573227355399 NA 5.41059440088988 5.50445123046855 -0.0938568295786721 0.976481861742915 0.511378587815224 0.125155630235085 0.0961173302401621 0.183536878185806 0.669094116098879 NA NA NA 0.692234708213039 99.482402686627 a7770 gain_cnaBRCA9_(KRAS) 263 FR-180204 ERK 4 45 2.99573227355399 NA 5.20598274078108 5.3713873025776 -0.165404561796525 0.451481396507743 0.752674506258516 0.224388240177044 0.366359639790137 0.219755764837496 0.669110885449675 NA NA NA 0.542825533513339 99.482402686627 a7771 gain_cnaBRCA31 56 WH-4-023 SRC family, ABL 3 9 1.63315443905142 NA 3.4766854335227 3.13881726653289 0.337868166989815 1.18830834377895 1.14192583329182 0.293453450877322 0.284327017275128 0.295875754045993 0.669168460639512 NA NA NA 0.693023547138799 99.482402686627 a7772 TP53_mut 299 OSI-027 MTORC1/2 37 11 2.99573227355399 NA 1.33651967478252 1.04175555339163 0.294764121390899 1.88123913403879 2.36324335986903 0.147681186787206 0.156686152258632 0.124728636244739 0.669179607249255 NA NA NA 0.710035465626968 99.482402686627 a7773 gain_cnaBRCA12_(TERT) 1194 SB-505124 TGFR1 (ALK5) 10 37 2.30258509299405 NA 4.50032626429363 4.35891066355623 0.141415600737393 1.11431136511806 0.869002688302296 0.153164332602465 0.126908515128004 0.162733214339838 0.669432919461928 NA NA NA 0.716376474580453 99.482402686627 a7774 loss_cnaBRCA7_(FAS,PTEN) 201 Epothilone B Microtubules 4 44 -3.44201937618241 NA -3.86252512336173 -4.26968817944683 0.4071630560851 1.8744698835385 1.81034391471282 0.224382316100321 0.217215042856002 0.224909230105977 0.669449393177012 NA NA NA 0.700707081160921 99.482402686627 a7775 gain_cnaBRCA8_(CHD4,WNK1) 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 3 23 2.30258509299405 NA 4.45030222830961 4.71650779831162 -0.266205570002011 0.395454878363509 1.04130692851751 0.265279746849138 0.673162943655257 0.255645634069681 0.669485070661609 NA NA NA 0.427092059921911 99.482402686627 a7776 gain_cnaBRCA13_(FGFR1,WHSC1L1) 52 GNF-2 ABL [T315I] 3 9 0.246860077931526 NA 2.35933580864978 2.52933845923106 -0.170002650581281 0.943319043620755 0.4449148173741 0.293138728231136 0.18021755389222 0.382101570778518 0.669499081019469 NA NA NA 0.788324049321825 99.482402686627 a7777 ARID1A_mut 1004 Vinblastine Microtubules 5 40 -2.30258509299405 NA -3.68933890113053 -3.42633803746525 -0.263000863665287 1.92441935294703 1.20733266535662 0.203726234852599 0.136665048219626 0.217836285898554 0.669709276854528 NA NA NA 0.779002034959062 99.482402686627 a7778 NF1_mut 190 Bleomycin DNA damage 5 43 4.15888308335967 NA 1.57712460492569 2.13668689486474 -0.559562289939048 2.37959742823855 2.79226063524373 0.202826063433777 0.235149980958439 0.200397585696797 0.669736519262816 NA NA NA 0.64470529181384 99.482402686627 a7779 BRCA2_mut 1013 Nilotinib ABL 5 35 0.693147180559945 NA 3.02972486260605 3.22764774237692 -0.197922879770873 0.751978426350106 0.986098505036612 0.205285396306155 0.263202869704036 0.200713091805696 0.670067777233108 NA NA NA 0.616406581397277 99.482402686627 a7780 CDH1_mut 1502 Bicalutamide ANDR (androgen receptor) 4 41 2.30258509299405 NA 4.43813878658656 4.57002648381357 -0.131887697227006 0.0664695382011038 0.608324943530088 0.224687306649225 1.98418254130154 0.216804684124353 0.670109963072126 NA NA NA 0.197194095389657 99.482402686627 a7781 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1194 SB-505124 TGFR1 (ALK5) 8 39 2.30258509299405 NA 4.26148951487493 4.41515489937224 -0.153665384497312 0.727522266679389 0.954998423248039 0.166430339045754 0.211217431459086 0.160906427441715 0.670110234991025 NA NA NA 0.616522968366737 99.482402686627 a7782 loss_cnaBRCA28_(GPS2) 135 Gemcitabine DNA replication 4 43 0.0237165266173161 NA -0.845030919415278 -0.22221840976441 -0.622812509650868 2.11676312233456 2.82050775683694 0.224102511568313 0.294228722656493 0.220815740761983 0.670180736486372 NA NA NA 0.614179996670021 99.482402686627 a7783 loss_cnaBRCA7_(FAS,PTEN) 223 ZSTK474 PI3K 4 45 1.63315443905142 2.32630161961136 1.21118646448359 0.885773649941327 0.32541281454226 1.47719975673041 1.45410163282155 0.223561236563384 0.220290325028566 0.223789594342747 0.670256104862449 NA NA NA 0.696889925045188 99.482402686627 a7784 gain_cnaBRCA30_(CRNKL1,FOXA2) 293 MP470 PDGFR 5 43 2.99573227355399 NA 3.83580910342545 3.4962103001279 0.33959880329755 2.02201050411992 1.64253696761552 0.202269415799025 0.1679510579226 0.206752608917257 0.670587793710849 NA NA NA 0.733320346552953 99.482402686627 a7785 gain_cnaBRCA48 1008 Methotrexate Dihydrofolate reductase (DHFR) 5 40 -1.6094379124341 NA 0.484749032418488 0.707387704702284 -0.222638672283796 0.939385594585943 1.11093128127461 0.203117700912059 0.237004562947263 0.200407240336553 0.670635746010444 NA NA NA 0.64375109278011 99.482402686627 a7786 loss_cnaBRCA18 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 15 30 -0.669430653942629 NA -3.70688553817718 -3.37584446624771 -0.331041071929473 1.55234476923254 2.77573898717272 0.135363833282631 0.213252286792667 0.11926232021789 0.670745322895956 NA NA NA 0.611070035526052 99.482402686627 a7787 PTEN_mut 166 FTI-277 Farnesyl transferase (FNTA) 8 39 0.0237165266173161 NA 2.35732674286409 2.22122097731121 0.136105765552885 0.410248901753431 0.874465022706087 0.166042152997476 0.331763875469647 0.155644607867444 0.670832935829134 NA NA NA 0.506481415439585 99.482402686627 a7788 loss_cnaBRCA17 186 Bexarotene Retinioic acid X family agonist 11 36 2.07944154167984 NA 3.73369395395422 3.56490064531299 0.168793308641223 0.966944915451043 1.1930276700778 0.147206140832752 0.174563520572925 0.141483146514293 0.671204484600641 NA NA NA 0.637561211147103 99.482402686627 a7789 TP53_mut 204 Tipifarnib Farnesyl-transferase (FNTA) 38 10 2.77258872223978 NA 1.57181580245053 1.80298728269435 -0.231171480243819 1.39379215323224 1.96507206666223 0.151834220124024 0.165857929180994 0.117640204736346 0.671219903993479 NA NA NA 0.732969766525999 99.482402686627 a7790 loss_cnaBRCA18 1248 FK866 NAMPT 15 29 0 NA -0.406036884211843 -0.777258794239006 0.371221910027163 2.55024909738605 2.81633468120013 0.135952722149281 0.145563000260507 0.131810296732551 0.671220386285122 NA NA NA 0.661935765932907 99.482402686627 a7791 loss_cnaBRCA38 1050 ZM-447439 AURKB 3 36 1.38629436111989 0.693147180559945 3.20262043064572 2.86169938580186 0.340921044843867 0.540086068934319 1.35741986246908 0.257069738201426 0.631234657684397 0.251153717629967 0.671283808973619 NA NA NA 0.420146678709566 99.482402686627 a7792 gain_cnaBRCA27_(CLTC,PPM1D) 301 PHA-793887 CDK-pan 9 39 2.32630161961136 NA 3.13409126884093 2.87338805321714 0.260703215623788 1.83612186249504 1.60922392018039 0.157913323806099 0.141985791329519 0.162005555817592 0.671354398231243 NA NA NA 0.702118996758066 99.482402686627 a7793 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 207 AS601245 JNK 6 42 2.07944154167984 NA 2.05587067828005 2.29624786098913 -0.240377182709084 0.354079993811072 1.36147230472812 0.186246294004908 0.678878182644071 0.176556792139144 0.671556569131202 NA NA NA 0.353076478091582 99.482402686627 a7794 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1021 Axitinib PDGFR, KIT, VEGFR 17 28 0.693147180559945 NA 2.55844159885518 2.4040116624104 0.154429936444785 1.10797852438812 1.21666755968399 0.131162071757532 0.139379900463386 0.126928621722187 0.671809869058263 NA NA NA 0.664939157042009 99.482402686627 a7795 gain_cnaBRCA30_(CRNKL1,FOXA2) 328 SNX-2112 HSP90 5 43 0.940007258491471 NA 0.0472258470412488 0.460264853238247 -0.413039006196998 2.84248202515048 1.95936042896487 0.201354505709828 0.145309276379727 0.210802974323211 0.671987903554115 NA NA NA 0.766054761409535 99.482402686627 a7796 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1017 Olaparib PARP1, PARP2 5 40 1.6094379124341 NA 3.91329312249964 4.09419871973256 -0.180905597232925 0.900890003092103 0.894129380137802 0.202183278484365 0.200807642011796 0.202325973457045 0.672059377025857 NA NA NA 0.689272187367792 99.482402686627 a7797 NF1_mut 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 5 44 3.68887945411394 NA 3.67640168766718 3.43480599515703 0.241595692510155 1.40444904677417 1.18113496550132 0.201035386293366 0.172021685703065 0.204545373362656 0.672069367319918 NA NA NA 0.727529960294438 99.482402686627 a7798 loss_cnaBRCA57 1028 VX-702 p38 5 40 0.693147180559945 NA 3.55045020603453 3.41137908502613 0.139071121008396 0.446363198331041 0.708004994594364 0.202174316102499 0.311564935300189 0.196426751322671 0.672073037490455 NA NA NA 0.563033840242348 99.482402686627 a7799 gain_cnaBRCA13_(FGFR1,WHSC1L1) 17 Cyclopamine SMO 3 10 2.77258872223978 NA 4.5099848970269 4.75133694161961 -0.241352044592716 0.790785175014107 0.854407654091436 0.286234443124498 0.305205575696852 0.282478795030653 0.672099595589818 NA NA NA 0.675569605405905 99.482402686627 a7800 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1046 681640 WEE1, CHEK1 15 21 0.693147180559945 NA 2.54333819501749 2.69840680401771 -0.155068609000224 1.15478201180429 1.0144973671588 0.144319400060801 0.134283879914216 0.152852648040388 0.672141550877043 NA NA NA 0.679474846170697 99.482402686627 a7801 BRCA2_mut 1243 piperlongumine Increases ROS levels 5 42 2.30258509299405 NA 1.86483610536855 1.69184372831061 0.17299237705794 1.15144591331352 0.824302294659608 0.20151828741881 0.150239255754636 0.209865213500803 0.672163038703059 NA NA NA 0.758924978832859 99.482402686627 a7802 gain_cnaBRCA27_(CLTC,PPM1D) 224 AS605240 PI3Kgamma 9 40 2.99573227355399 2.32630161961136 3.06648502247642 3.31610538786453 -0.249620365388111 1.29854510270246 1.64266226736188 0.15705720882045 0.192230801123977 0.151960856682367 0.67226428548551 NA NA NA 0.628404139325926 99.482402686627 a7803 ARID1A_mut 136 Mitomycin C DNA crosslinker 5 43 2.77258872223978 NA -0.402104308841502 -0.103165864423284 -0.298938444418217 2.16674373691985 1.40510392563389 0.20104778499246 0.137966682134351 0.212751839180405 0.672457549443497 NA NA NA 0.776949305928948 99.482402686627 a7804 loss_cnaBRCA36_(FAT1,IRF2) 134 Etoposide TOP2 9 38 2.77258872223978 NA 2.20016660838901 2.54269158630535 -0.34252497791634 2.01361167329921 2.20408519956659 0.157740594539463 0.170104783587755 0.155404599597009 0.672494622004933 NA NA NA 0.659867906590877 99.482402686627 a7805 gain_cnaBRCA12_(TERT) 177 GSK-650394 SGK3 9 38 2.77258872223978 NA 4.23195403399878 3.96292204794706 0.269031986051716 1.06694279960289 1.81442521825993 0.157729776698091 0.252152211113706 0.148273945569233 0.672515733836876 NA NA NA 0.56637232651769 99.482402686627 a7806 PTEN_mut 165 DMOG Prolyl-4-Hydroxylase 8 38 8.29404964010203 NA 7.35885973968028 7.61442707013339 -0.255567330453103 1.07672723331042 1.61737046591062 0.165514966065211 0.237355685401731 0.158014095001551 0.672549381944811 NA NA NA 0.588780556511436 99.482402686627 a7807 gain_cnaBRCA10_(MDM2,NUP107) 172 Embelin XIAP 4 44 3.46573590279973 NA 3.19117171343262 2.97505222219333 0.216119491239291 0.639472782071612 0.992339605609658 0.222063178606026 0.337965113290917 0.217787831925256 0.672659991642267 NA NA NA 0.570348472743566 99.482402686627 a7808 gain_cnaBRCA9_(KRAS) 152 CP466722 ATM 4 45 2.77258872223978 NA 2.51274438984079 2.74946597141825 -0.236721581577463 0.128992480953553 1.10243416037704 0.221822287988955 1.83515798616743 0.214726275804538 0.6726667480939 NA NA NA 0.186929086036298 99.482402686627 a7809 gain_cnaBRCA8_(CHD4,WNK1) 286 KIN001-236 TIE2 4 45 2.32630161961136 NA 4.38302570813904 4.55406650497747 -0.17104079683843 0.774085432156818 0.77104773918519 0.221773190026435 0.220958552807102 0.221829062126787 0.672734861456817 NA NA NA 0.696217668701163 99.482402686627 a7810 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 5 38 1.6094379124341 NA 2.61109483612964 2.90175686545082 -0.290662029321183 1.35650203867825 1.44456495644644 0.202381122430498 0.214273197557742 0.201210771467279 0.672759057409643 NA NA NA 0.672689079980676 99.482402686627 a7811 gain_cnaBRCA10_(MDM2,NUP107) 152 CP466722 ATM 5 44 2.77258872223978 NA 2.53798970624426 2.75197722140826 -0.213987515163995 0.484313638555914 1.10588095687501 0.200518620483931 0.441836649081461 0.193499593092442 0.672861825988647 NA NA NA 0.452144396460752 99.482402686627 a7812 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 45 Z-LLNle-CHO g-secretase 3 9 0.940007258491471 NA 1.31504745779574 0.861458382346675 0.453589075449067 2.08063183918173 1.40656670887048 0.289873239989778 0.218005447627609 0.322479604122946 0.672933880614992 NA NA NA 0.751186876360448 99.482402686627 a7813 gain_cnaBRCA27_(CLTC,PPM1D) 45 Z-LLNle-CHO g-secretase 3 9 0.940007258491471 NA 1.31504745779574 0.861458382346675 0.453589075449067 2.08063183918173 1.40656670887048 0.289873239989778 0.218005447627609 0.322479604122946 0.672933880614992 NA NA NA 0.751186876360448 99.482402686627 a7814 loss_cnaBRCA36_(FAT1,IRF2) 34 Imatinib ABL, KIT, PDGFR 3 11 0.693147180559945 NA 2.88451928403836 2.74818715677875 0.13633212725961 0.21070958124154 0.521579114813895 0.281769539764379 0.647014371422104 0.261383409318939 0.672977553094937 NA NA NA 0.509894098984185 99.482402686627 a7815 gain_cnaBRCA8_(CHD4,WNK1) 308 XL-880 MET 4 45 1.63315443905142 NA 2.1760066658947 1.8185489858335 0.357457680061204 1.7588519178282 1.60274012794962 0.221589012996818 0.203233527756325 0.223029094877969 0.672990394044785 NA NA NA 0.717826047778189 99.482402686627 a7816 MLL3_mut 269 NSC-207895 MDM4 3 46 2.99573227355399 NA 4.32025842873838 4.62244352802259 -0.302185099284216 1.90952734532834 1.15243995617758 0.252986311761049 0.158251255224761 0.26221331329617 0.67309509280154 NA NA NA 0.810828205748494 99.482402686627 a7817 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1529 MLN4924 NEDD8-activating enzyme 6 31 0 NA 0.641363039974187 0.316541510874028 0.324821529100159 1.50279284991425 1.74429715648543 0.189745086048835 0.216145245247004 0.186219147289467 0.673129172940351 NA NA NA 0.650078311723232 99.482402686627 a7818 gain_cnaBRCA8_(CHD4,WNK1) 185 OSI-906 IGF1R 3 45 0.940007258491471 NA 2.62437393616236 2.9114309776923 -0.287057041529939 1.05409348853544 1.1377513425476 0.253082632412917 0.272325979291246 0.252302089916392 0.673228994016719 NA NA NA 0.688563452063643 99.482402686627 a7819 gain_cnaBRCA12_(TERT) 158 PF-562271 FAK 9 36 0.940007258491471 NA 2.16911178436184 2.3742848108517 -0.205173026489865 1.29465460885903 1.29708743359657 0.158234970572442 0.158477037107744 0.158179796654849 0.673253311125069 NA NA NA 0.678097075643539 99.482402686627 a7820 loss_cnaBRCA7_(FAS,PTEN) 1050 ZM-447439 AURKB 4 35 1.38629436111989 0.693147180559945 3.15482284151061 2.85742136613604 0.297401475374562 0.438016365741185 1.37736716349061 0.224246529085293 0.678973432582404 0.215920259505002 0.673391165952677 NA NA NA 0.370145370219294 99.482402686627 a7821 loss_cnaBRCA34 312 AV-951 VEGFR 5 43 -2.05572501506252 NA 0.516448549491054 0.645744138989617 -0.129295589498564 0.388612743009879 0.66452676194638 0.200385236514966 0.332710627287064 0.194567919461754 0.673472483593188 NA NA NA 0.540608234497512 99.482402686627 a7822 gain_cnaBRCA12_(TERT) 1239 YK 4-279 RNA helicase A 9 33 2.30258509299405 NA 1.8501622684538 2.05811395606634 -0.207951687612544 0.860635647983164 1.39172021642864 0.159602162097305 0.241625696193114 0.149420612819851 0.673536140855981 NA NA NA 0.585602495782795 99.482402686627 a7823 gain_cnaBRCA63 200 LAQ824 HDAC 6 42 0.0237165266173161 NA -2.45483163114383 -2.71727252113372 0.262440889989894 1.70349423172583 1.3799569241166 0.184986539831934 0.154060333813993 0.190180494335284 0.673645347620203 NA NA NA 0.730637161670614 99.482402686627 a7824 gain_cnaBRCA12_(TERT) 312 AV-951 VEGFR 9 39 -2.05572501506252 NA 0.714397303012745 0.613324743510105 0.10107255950264 0.375969553623445 0.688638181419372 0.156643817644659 0.268831767169822 0.146771646170295 0.673838637608975 NA NA NA 0.55095635001631 99.482402686627 a7825 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1001 AICAR AAPK1 (AMPK) agonist 5 40 7.60090245954208 NA 7.98667091371065 7.70745984344836 0.279211070262294 1.10623252913816 1.4148802144115 0.201006496574279 0.252398173899136 0.197339016701444 0.673853985737525 NA NA NA 0.626145966022864 99.482402686627 a7826 PTEN_mut 1261 rTRAIL TR10A (DR4), TR10B (DR5) 8 39 -2.30258509299405 NA -0.282876637174242 -0.111422056441153 -0.171454580733089 0.97630854961881 1.05498625144624 0.164364343017271 0.175615158548014 0.162518308175153 0.673960193088172 NA NA NA 0.664430285878831 99.482402686627 a7827 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1004 Vinblastine Microtubules 7 38 -2.30258509299405 NA -3.26568836628943 -3.49053677474307 0.224848408453633 1.39168212335271 1.27395841835058 0.174162089458766 0.161565924201103 0.176495877114066 0.674087418863628 NA NA NA 0.701186276927611 99.482402686627 a7828 gain_cnaBRCA48 166 FTI-277 Farnesyl transferase (FNTA) 5 42 0.0237165266173161 NA 2.3910336047579 2.22693009605382 0.164103508704085 0.658824954363939 0.833780113390816 0.200189219590043 0.249085144114674 0.196818688846762 0.674196350760459 NA NA NA 0.62906587718094 99.482402686627 a7829 gain_cnaBRCA47_(EGFR) 261 TL-1-85 MAP3K7 (TAK1) 7 42 2.32630161961136 NA 3.84441618146462 4.05487151335572 -0.210455331891094 1.42325245156952 1.18571456786184 0.172699800135516 0.147869291676968 0.177492406347509 0.674205392011302 NA NA NA 0.721395306837898 99.482402686627 a7830 loss_cnaBRCA24 269 NSC-207895 MDM4 3 46 2.99573227355399 NA 4.32131837658431 4.62237440098916 -0.301056024404855 0.601860465337485 1.21413287671843 0.252037456900422 0.500209004816493 0.247959700439504 0.674248342487436 NA NA NA 0.494169160945356 99.482402686627 a7831 gain_cnaBRCA62 1042 BIRB 0796 p38, JNK2 7 36 2.30258509299405 NA 4.50269958956322 4.34013088114529 0.162568708417935 0.58659619862232 0.976431529604536 0.174870861605311 0.277139041814018 0.166492686367652 0.674263845655245 NA NA NA 0.564196641101959 99.482402686627 a7832 CDH1_mut 194 AUY922 HSP90 4 43 -1.36257783450257 NA -2.74523881922799 -2.36105016835568 -0.384188650872313 1.34974724939626 1.7619454303011 0.221114433166135 0.2846374764195 0.218047985065383 0.674315596222931 NA NA NA 0.624738233838669 99.482402686627 a7833 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1006 Cytarabine DNA synthesis 5 40 0.693147180559945 NA 1.48281047256109 1.17424862507309 0.308561847488005 1.00384493928024 1.58222220793036 0.200674338650871 0.307379990090149 0.195018023348074 0.674360879658089 NA NA NA 0.567697628132659 99.482402686627 a7834 gain_cnaBRCA10_(MDM2,NUP107) 185 OSI-906 IGF1R 4 44 0.940007258491471 NA 2.66389698783283 2.91436199666611 -0.250465008833283 1.37154866446804 1.11582236905424 0.220818184014537 0.182614744428646 0.224466739312257 0.674386104885898 NA NA NA 0.74385430961611 99.482402686627 a7835 loss_cnaBRCA7_(FAS,PTEN) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 4 44 0.246860077931526 2.32630161961136 0.0715723803760096 -0.295544985157866 0.367117365533876 2.09446072520041 1.62829975829489 0.220797213801345 0.175280138279388 0.225460553969689 0.674415194073865 NA NA NA 0.753244232924346 99.482402686627 a7836 loss_cnaBRCA33 1025 SB 216763 GSK3A, GSK3B 5 34 2.30258509299405 NA 4.74909549743901 4.90975925027459 -0.160663752835581 0.340581895943592 0.830441819043454 0.202800936244259 0.471733097822059 0.193467801297196 0.674446637739714 NA NA NA 0.454938033806258 99.482402686627 a7837 gain_cnaBRCA8_(CHD4,WNK1) 272 AR-42 HDAC 4 45 1.63315443905142 NA -0.169607188790831 0.169664247783887 -0.339271436574718 1.31724755732015 1.55242147905702 0.220523095926099 0.257560877368368 0.218543379585806 0.674470043255764 NA NA NA 0.653773600544976 99.482402686627 a7838 loss_cnaBRCA33 1149 TW 37 BCL2, BCL2L1 4 39 1.6094379124341 NA -0.395074935484133 -0.116467248135999 -0.278607687348133 1.58210997393948 1.22536551078076 0.222013671789671 0.176098812305945 0.227367005923494 0.674599238579236 NA NA NA 0.752644919826555 99.482402686627 a7839 gain_cnaBRCA15 1149 TW 37 BCL2, BCL2L1 21 22 1.6094379124341 NA -0.0595905504783071 -0.221414584508912 0.161824034030605 1.03164345015733 1.43562636005794 0.128952217003831 0.156860428868062 0.112720160713735 0.674734676355324 NA NA NA 0.672569342105634 99.482402686627 a7840 gain_cnaBRCA8_(CHD4,WNK1) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 3 44 0.940007258491471 NA 1.5912091000314 1.90893935644496 -0.317730256413565 1.17630096103181 1.26433046505049 0.252057127610971 0.270109663206314 0.251303172071296 0.674735335565894 NA NA NA 0.690945551754828 99.482402686627 a7841 gain_cnaBRCA27_(CLTC,PPM1D) 1043 JNK Inhibitor VIII JNK 10 33 2.30258509299405 NA 4.70943258079229 4.82396712068682 -0.114534539894526 0.813934885312563 0.731919210834227 0.152572225003774 0.140717079414213 0.156485221591577 0.674746899732529 NA NA NA 0.696178251315685 99.482402686627 a7842 gain_cnaBRCA62 293 MP470 PDGFR 10 38 2.99573227355399 NA 3.33225529310472 3.58404040767315 -0.251785114568425 1.74542727935612 1.66248843802819 0.149957960511819 0.14425414197795 0.151450746248231 0.675041352420273 NA NA NA 0.688280062924755 99.482402686627 a7843 CDH1_mut 190 Bleomycin DNA damage 4 44 4.15888308335967 NA 2.63564566220557 2.02774038306795 0.607905279137623 1.89098634796338 2.80958543661071 0.220334144919108 0.321475234230192 0.216368319402651 0.675057675982139 NA NA NA 0.586712175310089 99.482402686627 a7844 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 258 STF-62247 stimulates autophagy 15 34 2.32630161961136 NA 4.54315091606291 4.66953054772882 -0.126379631665916 0.775964696307042 1.03698256409425 0.130742325469934 0.162867759664041 0.121872475046195 0.675096446106966 NA NA NA 0.640000404103516 99.482402686627 a7845 loss_cnaBRCA18 185 OSI-906 IGF1R 16 32 0.940007258491471 NA 2.79582073135101 2.94232450321951 -0.146503771868495 1.07041436489739 1.16390987482267 0.129161364703665 0.136866410497526 0.125872092880745 0.675107330393445 NA NA NA 0.66715010077765 99.482402686627 a7846 loss_cnaBRCA34 205 BMS-708163 g-secretase 5 43 2.32630161961136 0.940007258491471 4.77467760348205 4.91069834484492 -0.136020741362871 0.50328856856922 0.69754799037775 0.199194698796552 0.270263919861242 0.194998399019414 0.675297768421641 NA NA NA 0.604645222502391 99.482402686627 a7847 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 6 PHA-665752 MET 5 9 0.693147180559945 NA 2.98400756350215 2.79794030832355 0.186067255178603 0.451489073951742 0.896582936801745 0.239443857541678 0.41211906536301 0.207529328901054 0.675322141404857 NA NA NA 0.615322798939115 99.482402686627 a7848 loss_cnaBRCA34 1239 YK 4-279 RNA helicase A 5 37 2.30258509299405 NA 1.78285515266794 2.04472824872794 -0.261873096060003 1.27756335931004 1.30576638720947 0.200981128887771 0.204978558716204 0.200551261408749 0.675422397166821 NA NA NA 0.685084217275552 99.482402686627 a7849 gain_cnaBRCA48 194 AUY922 HSP90 5 42 -1.36257783450257 NA -2.70317962122135 -2.35690986690713 -0.346269754314224 1.92891403150418 1.71772685737404 0.199287497209487 0.179515389830101 0.201586039612597 0.675577279269871 NA NA NA 0.717645554855045 99.482402686627 a7850 ARID1A_mut 279 BIX02189 MAP2K5 (MEK5) 5 44 2.99573227355399 NA 4.86591156750444 5.04570200784533 -0.179790440340895 0.922846900233606 0.903302396116307 0.198667379427028 0.194821524887155 0.199036824339106 0.675703771892455 NA NA NA 0.696534783436778 99.482402686627 a7851 gain_cnaBRCA15 288 KIN001-055 JAK3, MNK1 22 27 2.32630161961136 NA 4.28171447501205 4.38568977931002 -0.10397530429797 0.663765368691697 0.990477727009589 0.120904519905326 0.156644665724138 0.104974903990914 0.67570527893279 NA NA NA 0.663486306033617 99.482402686627 a7852 loss_cnaBRCA33 127 GSK269962A ROCK1, ROCK2 5 9 0.916290731874155 NA 2.64188139056066 2.37151561601112 0.270365774549541 0.610576426067254 1.31598647544925 0.239082554764621 0.442804148681235 0.205447228822959 0.675780661290845 NA NA NA 0.610451012395377 99.482402686627 a7853 gain_cnaBRCA62 1527 GDC0941 (rescreen) PI3K 7 38 1.38629436111989 NA 1.15076740385572 0.949319500904542 0.20144790295118 0.89017830579708 1.20153837817171 0.17319803760497 0.226300620492881 0.167658317545968 0.675784930419958 NA NA NA 0.615133497854921 99.482402686627 a7854 gain_cnaBRCA48 1047 Nutlin-3a MDM2 4 39 2.07944154167984 1.38629436111989 4.00407513317869 4.22775168958471 -0.223676556406023 1.57645605437627 0.952751917865177 0.22113037104273 0.14188569087295 0.234768938494727 0.675817373568131 NA NA NA 0.797453339605864 99.482402686627 a7855 gain_cnaBRCA12_(TERT) 253 XMD14-99 EPHB3, CAMK1 9 39 2.32630161961136 NA 4.83482586913384 4.95578091047431 -0.120955041340476 0.631091591356668 0.804903730825604 0.155574819361604 0.191660042689615 0.150272680704822 0.675933366746043 NA NA NA 0.631177100158637 99.482402686627 a7856 gain_cnaBRCA47_(EGFR) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 7 41 2.77258872223978 NA -0.644584158470611 -0.401005282062226 -0.243578876408385 1.63849242245932 1.379329213634 0.1720401232492 0.14866036184823 0.1765922696342 0.675948938472849 NA NA NA 0.720518371545615 99.482402686627 a7857 loss_cnaBRCA34 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 5 40 2.30258509299405 NA 1.16853886400726 1.38992215924624 -0.221383295238982 1.13165082592054 1.10659614343657 0.199633127956948 0.195628625162623 0.200057895151766 0.675950823636376 NA NA NA 0.696406803011333 99.482402686627 a7858 gain_cnaBRCA15 167 OSU-03012 PDPK1 (PDK1) 22 26 2.77258872223978 NA 2.32655367619431 2.18149278645276 0.145060889741553 1.15714658539695 1.21827386934381 0.12182238350372 0.125360858833448 0.11907083734767 0.676051177976816 NA NA NA 0.674741457736592 99.482402686627 a7859 gain_cnaBRCA8_(CHD4,WNK1) 1114 Cetuximab EGFR 3 42 4.18661983833127 NA 6.07545467442921 6.29738008232621 -0.221925407896999 0.638514360826424 0.893255750628546 0.251320233176759 0.347565256965815 0.248445540642576 0.676185923277455 NA NA NA 0.617827165813481 99.482402686627 a7860 TP53_mut 300 CX-5461 RNA Pol I 38 11 2.32630161961136 NA 3.96778933149164 3.72090043375273 0.246888897738913 1.63729206844686 1.98616620867502 0.143751843089826 0.150790993553834 0.124304248385946 0.676501589918625 NA NA NA 0.711855317007256 99.482402686627 a7861 gain_cnaBRCA27_(CLTC,PPM1D) 231 FMK RSK 9 40 2.99573227355399 2.32630161961136 5.51380614887785 5.60619999577767 -0.0923938468998209 0.532484179424617 0.609033593898853 0.154841935875091 0.173514726765513 0.151705665870322 0.676614993243694 NA NA NA 0.654737505408178 99.482402686627 a7862 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1175 AG-014699 PARP1, PARP2 6 37 1.6094379124341 NA 3.69728084938311 3.88821223760755 -0.190931388224441 0.6938214078228 1.07161676853464 0.18483754990521 0.275188090294851 0.178171333102156 0.676690184277557 NA NA NA 0.58045923071186 99.482402686627 a7863 gain_cnaBRCA27_(CLTC,PPM1D) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 9 38 2.32630161961136 NA 1.22317880889128 1.46282620251638 -0.239647393625097 2.5040644007129 1.23875473884007 0.155456714687266 0.0957033667172736 0.193458306241876 0.676957682100173 NA NA NA 0.7864859515205 99.482402686627 a7864 gain_cnaBRCA19 253 XMD14-99 EPHB3, CAMK1 4 44 2.32630161961136 NA 4.77707907800039 4.94728572769775 -0.170206649697366 1.09442294405203 0.750391323599031 0.218920248448806 0.155521821451574 0.226823850895583 0.677020889784741 NA NA NA 0.779084360125408 99.482402686627 a7865 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1043 JNK Inhibitor VIII JNK 5 38 2.30258509299405 NA 4.92964850577516 4.77992100688716 0.149727498888004 0.554413163393492 0.768943010926855 0.199446023533181 0.270064833907517 0.194718590012969 0.677225557900309 NA NA NA 0.608273888423511 99.482402686627 a7866 loss_cnaBRCA17 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 37 1.6094379124341 NA 2.82342551733163 2.52581424314668 0.297611274184958 1.36923886030197 1.64464900458771 0.184441468068032 0.217355264164298 0.180957318768186 0.677342490012356 NA NA NA 0.645297584545122 99.482402686627 a7867 loss_cnaBRCA36_(FAT1,IRF2) 1378 Bleomycin (50 uM) DNA damage 10 38 3.91202300542815 NA 3.58933392120249 3.87150279526752 -0.282168874065037 1.30676474464494 2.01424580250699 0.148767901155369 0.21592935929849 0.140086613914668 0.677469691859302 NA NA NA 0.597669787186798 99.482402686627 a7868 loss_cnaBRCA60 167 OSU-03012 PDPK1 (PDK1) 3 45 2.77258872223978 NA 1.96957321026333 2.26653941540571 -0.296966205142373 0.523692862711291 1.2124144931398 0.249387513937891 0.567061776639275 0.244937854853018 0.677721030898479 NA NA NA 0.450717356106961 99.482402686627 a7869 loss_cnaBRCA28_(GPS2) 196 Phenformin AAPK1 (AMPK) agonist 3 45 8.29404964010203 NA 6.77607587264005 7.23040889814447 -0.454333025504419 0.412838194526599 1.86072324833924 0.249378934339495 1.10051112403832 0.244170123584971 0.677731474703758 NA NA NA 0.241845288347583 99.482402686627 a7870 gain_cnaBRCA47_(EGFR) 1018 ABT-888 PARP1, PARP2 7 38 1.6094379124341 NA 4.30596236675998 4.42096558088598 -0.115003214125992 0.637349289168539 0.673313658705763 0.172054497923082 0.180439856261582 0.170801843448491 0.677800700073435 NA NA NA 0.674344018243975 99.482402686627 a7871 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1047 Nutlin-3a MDM2 16 27 2.07944154167984 1.38629436111989 4.29076432654206 4.15727360006836 0.133490726473702 1.02081444961128 1.00615733574445 0.131967252790685 0.130768844939973 0.132673809285437 0.6779205787143 NA NA NA 0.679742016937564 99.482402686627 a7872 loss_cnaBRCA7_(FAS,PTEN) 208 SB-715992 KIF11 4 45 -2.05572501506252 NA -1.58377660630411 -1.20933241043485 -0.374444195869255 1.48033054893374 1.73253492374338 0.218011462869952 0.252946341031037 0.21612504933535 0.677961691522142 NA NA NA 0.659257083579433 99.482402686627 a7873 loss_cnaBRCA20 1016 Temsirolimus MTOR 3 41 -1.6094379124341 NA -1.39982091857971 -1.77663266939838 0.376811750818669 2.37675015850755 1.45074531914934 0.249909610666848 0.158540749211639 0.259736664902435 0.67819325103963 NA NA NA 0.810658846774276 99.482402686627 a7874 gain_cnaBRCA61_(NOTCH2) 283 GSK2126458 PI3K, MTOR 3 45 -2.05572501506252 0.0237165266173161 -3.43862356782121 -3.02980685975281 -0.408816708068401 0.736349039153783 1.67292414398761 0.248771759467438 0.555194189617216 0.244372531496819 0.678470741125925 NA NA NA 0.458372697842474 99.482402686627 a7875 gain_cnaBRCA31 175 PAC-1 CASP3 agonist 16 32 0.940007258491471 NA 2.2966732969167 2.45373605235819 -0.157062755441485 1.22876479861408 1.23000350690738 0.127734866248254 0.127821659294468 0.127692933035932 0.678487150746627 NA NA NA 0.679400058344727 99.482402686627 a7876 BRCA1_mut 235 QL-XII-47 BTK, BMX 4 45 2.32630161961136 NA 2.01036842407673 1.68120457666452 0.329163847412201 2.8644995239104 1.37270650694819 0.217622465079139 0.114911468710196 0.239791860638876 0.678503113983894 NA NA NA 0.834108853512666 99.482402686627 a7877 gain_cnaBRCA48 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 5 41 0 NA 0.288444587720443 0.697699359775218 -0.409254772054775 1.23783682038326 2.13744867457283 0.19752915401012 0.330620939138053 0.191468818373646 0.678710735028626 NA NA NA 0.545882811256965 99.482402686627 a7878 gain_cnaBRCA47_(EGFR) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 6 37 0.693147180559945 NA 1.94749511425683 1.63888516879368 0.30860994546315 0.901213996185662 1.76308899376217 0.183499936911132 0.342438030001004 0.175039346598507 0.678894100918901 NA NA NA 0.521950778075758 99.482402686627 a7879 TP53_mut 1010 Gefitinib EGFR 35 10 -0.693147180559945 NA 1.43470244132028 1.27808162143315 0.156620819887128 1.04302642409107 1.06665203495092 0.149445152413317 0.150159973198773 0.146834032800898 0.678910754175541 NA NA NA 0.686798200620573 99.482402686627 a7880 BRCA2_mut 1030 KU-55933 ATM 5 37 2.30258509299405 NA 4.05986376553953 4.24425011038686 -0.184386344847327 1.03518826884097 0.915677955743788 0.198623349958205 0.17811865763681 0.201365931865809 0.679008621645688 NA NA NA 0.720766325570312 99.482402686627 a7881 gain_cnaBRCA10_(MDM2,NUP107) 157 JNK-9L JNK 4 43 1.63315443905142 NA 0.267346844004957 0.0361696423675083 0.231177201637449 0.245241825497342 1.09720913879444 0.217702638896671 0.942649978928469 0.210695658159989 0.679049243628953 NA NA NA 0.278517925533559 99.482402686627 a7882 loss_cnaBRCA18 110 Roscovitine CDKs 5 8 2.77258872223978 NA 4.23615490312489 3.98244213122078 0.253712771904111 0.824262157629867 1.15626061574828 0.242143868102623 0.307805920186427 0.219425247602953 0.679209149618257 NA NA NA 0.654112688858209 99.482402686627 a7883 gain_cnaBRCA27_(CLTC,PPM1D) 104 Bortezomib Proteasome 3 11 -3.91202300542815 NA -4.963375951119 -4.46507953984618 -0.498296411272826 2.45568449479626 1.64502080658803 0.27597483550354 0.202915485408955 0.302911920188021 0.679277376580231 NA NA NA 0.765780213410398 99.482402686627 a7884 loss_cnaBRCA7_(FAS,PTEN) 136 Mitomycin C DNA crosslinker 4 44 2.77258872223978 NA -0.430468238040727 -0.107381380960132 -0.323086857080594 0.459058855853267 1.53324216469391 0.217269809831633 0.703802688829655 0.210721348864741 0.679315415054783 NA NA NA 0.341944844351514 99.482402686627 a7885 loss_cnaBRCA34 1129 PF-4708671 RPS6KB1 (p70S6KA) 3 40 2.30258509299405 NA 3.5418420693402 3.82900128739694 -0.287159218056739 0.538091374819425 1.17509644928361 0.249221984150179 0.533662555273451 0.244370764826839 0.679336492456934 NA NA NA 0.475821815257302 99.482402686627 a7886 loss_cnaBRCA29_(MAP2K4) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 5 38 0.693147180559945 NA 3.07675473222684 2.8862692147383 0.190485517488541 0.721316620672968 0.984389681833159 0.198031190377836 0.264080310960841 0.193506211009661 0.679382810532602 NA NA NA 0.615180085835812 99.482402686627 a7887 TP53_mut 1378 Bleomycin (50 uM) DNA damage 38 10 3.91202300542815 NA 3.8710862751518 3.59091669764224 0.280169577509556 1.68893797652505 2.58092511456175 0.147709839771379 0.165885059962946 0.10855393514861 0.679631598878861 NA NA NA 0.750902790138718 99.482402686627 a7888 BRCA2_mut 1264 SGC0946 Q8TEK3 (DOT1L) 5 41 -0.693147180559945 NA 2.05784430455704 1.93764895097527 0.120195353581769 0.410132015725633 0.627101515694736 0.196857172532843 0.29306503509391 0.191668096111377 0.679740927456648 NA NA NA 0.58252772004317 99.482402686627 a7889 TP53_mut 165 DMOG Prolyl-4-Hydroxylase 36 10 8.29404964010203 NA 7.52012441196309 7.74946277518399 -0.229338363220903 1.49813238208435 1.71169892902182 0.148513932481276 0.153082842319866 0.133982886436672 0.679817191549774 NA NA NA 0.706617024074188 99.482402686627 a7890 loss_cnaBRCA18 286 KIN001-236 TIE2 16 33 2.32630161961136 NA 4.47442868713761 4.57194656249517 -0.0975178753575534 0.641978837658788 0.824985044911659 0.126431348171324 0.151902009283029 0.118205628040198 0.680012476819728 NA NA NA 0.653309315791525 99.482402686627 a7891 gain_cnaBRCA10_(MDM2,NUP107) 328 SNX-2112 HSP90 5 43 0.940007258491471 NA 0.777670520703615 0.375329426068204 0.402341094635411 2.45000422629593 2.00944035554835 0.196119533043231 0.164220571669664 0.200225447610073 0.68002160290564 NA NA NA 0.739081461137319 99.482402686627 a7892 NF1_mut 1219 PFI-1 BRD2, BRD3, BRD4 5 42 2.30258509299405 NA 3.34857730689026 3.15151722381159 0.197060083078678 1.51120472210969 0.939674915153717 0.196325226478425 0.130399329882701 0.209710911615047 0.680121729330442 NA NA NA 0.788563500124244 99.482402686627 a7893 gain_cnaBRCA31 1129 PF-4708671 RPS6KB1 (p70S6KA) 13 30 2.30258509299405 NA 3.91979058200247 3.76094333792886 0.158847244073606 1.21310980921403 1.1260848309931 0.13785997855464 0.130942180886759 0.141061525474522 0.680174970626902 NA NA NA 0.691047577977435 99.482402686627 a7894 gain_cnaBRCA15 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 14 12 2.30258509299405 NA 4.76184013308465 4.59706868190925 0.164771451175405 1.00028393417981 1.00783593133403 0.164155487364873 0.164724680208434 0.16349035200333 0.68018571213991 NA NA NA 0.680471393569815 99.482402686627 a7895 gain_cnaBRCA64_(SDHC) 272 AR-42 HDAC 8 41 1.63315443905142 NA 0.348314418883735 0.101706025464432 0.246608393419302 2.63362664361457 1.25209612528923 0.160281689316344 0.0936383272159034 0.196956438438252 0.680256160389643 NA NA NA 0.802341270810627 99.482402686627 a7896 gain_cnaBRCA58_(CCND1) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 9 38 2.77258872223978 NA 4.88279881871364 5.04124158759635 -0.158442768882715 0.853952889163894 1.06512646336797 0.153715799027881 0.185540409656376 0.148754889050181 0.680367608388663 NA NA NA 0.64126534315547 99.482402686627 a7897 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1248 FK866 NAMPT 18 26 0 NA -0.85595922211053 -0.508607396081511 -0.34735182602902 2.31474542714855 2.98083097018474 0.127194712706725 0.150060486978436 0.116528521577825 0.680380866265044 NA NA NA 0.666263669677746 99.482402686627 a7898 gain_cnaBRCA8_(CHD4,WNK1) 1069 EHT 1864 Rac GTPases 3 43 2.30258509299405 NA 3.36156520174944 3.57536516885198 -0.213799967102537 1.73746277366167 0.798806370951162 0.247485397488728 0.123052977216863 0.267649301354418 0.680562842182873 NA NA NA 0.851534802805049 99.482402686627 a7899 loss_cnaBRCA17 1005 Cisplatin DNA crosslinker 8 37 1.79175946922805 2.30258509299405 3.82818268460854 3.63589995525699 0.192282729351553 0.907102511328817 1.23736474964277 0.161600544958905 0.211974641179063 0.155396967148988 0.680597786674275 NA NA NA 0.62090850127384 99.482402686627 a7900 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 15 34 1.63315443905142 NA 3.66621553603672 3.53714573443922 0.129069801597497 0.891636406179927 1.05016509309734 0.128356052804097 0.144756091948371 0.122904296139591 0.680685905910913 NA NA NA 0.661827016735108 99.482402686627 a7901 gain_cnaBRCA61_(NOTCH2) 253 XMD14-99 EPHB3, CAMK1 3 45 2.32630161961136 NA 5.11308923739255 4.92110268041167 0.191986556980885 0.471245894288347 0.788618545839261 0.246922261739964 0.407402078846362 0.243446667585747 0.680724566767036 NA NA NA 0.566114979647574 99.482402686627 a7902 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1004 Vinblastine Microtubules 15 30 -2.30258509299405 NA -3.34279402042433 -3.51194352326325 0.169149502838924 1.57560543041204 1.1284387055536 0.131007441195504 0.107355242355753 0.149896934593308 0.680727063081464 NA NA NA 0.714331736084998 99.482402686627 a7903 loss_cnaBRCA60 222 BX-912 PDPK1 (PDK1) 3 46 2.32630161961136 NA 4.23553483702345 3.86084029788153 0.374694539141919 0.866641519110224 1.54284796836761 0.246475034368265 0.432352398171064 0.242859015809809 0.68102479988681 NA NA NA 0.545771772893815 99.482402686627 a7904 MLL3_mut 197 Bryostatin 1 PRKC 3 45 -4.8283137373023 NA -3.03145453649108 -2.79182721553053 -0.239627320960552 0.266281911655739 0.992168166814033 0.246543651397613 0.89990085871981 0.241518856354789 0.681186311195019 NA NA NA 0.297685207706984 99.482402686627 a7905 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1161 ZG-10 IRAK1 3 23 2.30258509299405 NA 1.65567565169514 2.01711515490259 -0.361439503207455 0.886009555599836 1.45596599500635 0.255028496180915 0.407940863530255 0.248247214871167 0.681498078971918 NA NA NA 0.579508314222046 99.482402686627 a7906 gain_cnaBRCA15 300 CX-5461 RNA Pol I 22 27 2.32630161961136 NA 3.80013674329373 4.00381077835187 -0.203674035058145 1.72877291078723 1.70847127599964 0.118582539663406 0.117814221744947 0.119214199219694 0.68157756010079 NA NA NA 0.682038739132187 99.482402686627 a7907 loss_cnaBRCA29_(MAP2K4) 326 GSK690693 AKT 7 41 2.32630161961136 NA 3.21951753291247 2.89178373887958 0.327733794032888 1.71917224762939 1.97190741852872 0.168864501027106 0.19063464669396 0.166201410346849 0.681588667286343 NA NA NA 0.659431822544564 99.482402686627 a7908 loss_cnaBRCA34 176 IPA-3 PAK1, PAK2, PAK3 5 42 3.46573590279973 NA 4.76182979812804 4.46529297998885 0.296536818139188 0.904492258903358 1.56531889759145 0.195312206878691 0.327848928744532 0.18944179272062 0.681678583549525 NA NA NA 0.548333825621456 99.482402686627 a7909 gain_cnaBRCA27_(CLTC,PPM1D) 345 KIN001-270 CDK9 9 40 2.99573227355399 NA 5.02131357054583 5.12699850714359 -0.10568493659776 0.828181533247873 0.663346288347974 0.152245813122259 0.12761083452718 0.159320913456775 0.681727881034258 NA NA NA 0.727573505590425 99.482402686627 a7910 gain_cnaBRCA61_(NOTCH2) 294 MPS-1-IN-1 MPS1 3 46 2.99573227355399 NA 5.02848571162387 4.73878065891051 0.289705052713361 0.448019987216091 1.20115439259379 0.24573180636117 0.646634214945481 0.241188855071135 0.681932273395795 NA NA NA 0.404584174126394 99.482402686627 a7911 loss_cnaBRCA18 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 12 31 1.6094379124341 NA 2.73058388070688 2.50415075909465 0.226433121612232 1.34838091985905 1.70062424551112 0.140320537525312 0.167929639375127 0.133147061856793 0.68196009126841 NA NA NA 0.651126386638419 99.482402686627 a7912 POLR2B_mut 1003 Camptothecin TOP1 3 42 -2.30258509299405 NA -2.89699343375721 -2.50301630190598 -0.393977131851227 2.46771794516706 1.54329844776048 0.24651373209491 0.15965241595897 0.255282529716101 0.682025100121802 NA NA NA 0.809409787967505 99.482402686627 a7913 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 7 41 0.246860077931526 2.32630161961136 -0.0254805872875922 -0.305837212547047 0.280356625259455 1.5256514336014 1.68246338659891 0.168600221728219 0.18376191250819 0.166634607024759 0.682058847616264 NA NA NA 0.668984752937266 99.482402686627 a7914 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 269 NSC-207895 MDM4 9 40 2.99573227355399 NA 4.75223659104008 4.57057620639734 0.181660384642742 0.816820493855696 1.25815340434902 0.152067546147653 0.222399396206672 0.144386514406592 0.682079523320403 NA NA NA 0.596757117185023 99.482402686627 a7915 loss_cnaBRCA33 156 AZD6482 PI3Kbeta 6 41 1.63315443905142 NA 1.82218431425201 2.08713304404992 -0.264948729797911 1.10944087485631 1.5094518085669 0.180189442535094 0.238812843300214 0.175526458210984 0.682122330033544 NA NA NA 0.617874866500626 99.482402686627 a7916 ARID1A_mut 298 OSI-930 KIT, VEGFR, PDGFR 5 43 2.32630161961136 NA 3.76007484679928 3.93119199988908 -0.171117153089798 0.662371804669699 0.896777559795644 0.19469915637004 0.258340031812084 0.190813375313263 0.682207878534561 NA NA NA 0.61918416663904 99.482402686627 a7917 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 219 AT-7519 CDK9 6 43 2.32630161961136 NA 1.95912554347195 1.63193654428178 0.327188999190169 1.85309537698614 1.818545442912 0.179551994063861 0.176563496543986 0.179917967112357 0.68220915744825 NA NA NA 0.697883730430664 99.482402686627 a7918 gain_cnaBRCA48 260 NG-25 MAP3K7 (TAK1) 5 44 2.32630161961136 NA 3.43396201362517 3.18270492638557 0.251257087239606 1.53723543558922 1.26725841347868 0.194406332946112 0.163447368843211 0.198268233666639 0.682263245987189 NA NA NA 0.740163188469412 99.482402686627 a7919 CDH1_mut 1061 SB590885 BRAF 4 38 1.6094379124341 NA 4.22665898044387 3.98930671914859 0.237352261295286 1.04211536178454 1.09925705555783 0.216745237973958 0.227760063807945 0.215920616652161 0.682297930485119 NA NA NA 0.690151977703781 99.482402686627 a7920 loss_cnaBRCA20 269 NSC-207895 MDM4 3 46 2.99573227355399 NA 4.32896604006494 4.62187564032738 -0.292909600262441 0.759539188879705 1.21032262671313 0.245192538717501 0.385641194754511 0.24200952192218 0.682591010956352 NA NA NA 0.584136621115951 99.482402686627 a7921 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 140 Vinorelbine Microtubules 14 33 -2.74887219562247 NA -3.75244359820355 -3.53506648680013 -0.217377111403417 1.79643850377093 1.59529167964655 0.13127331588897 0.121004482450759 0.136261671879075 0.682605065100368 NA NA NA 0.698863600435861 99.482402686627 a7922 PIK3CA_mut 127 GSK269962A ROCK1, ROCK2 4 10 0.916290731874155 NA 2.6682899252267 2.38798877959966 0.280301145627043 0.942217219968875 1.18757139175305 0.247783782497237 0.297491002803263 0.236028880093913 0.682738701034157 NA NA NA 0.655739421074789 99.482402686627 a7923 gain_cnaBRCA47_(EGFR) 1170 CCT018159 HSP90 7 36 2.30258509299405 NA 3.17215093596267 3.37601569692496 -0.203864760962285 0.815488150435502 1.25291057164059 0.170042037660228 0.249991076943808 0.162712938638023 0.682744090579299 NA NA NA 0.59375668399831 99.482402686627 a7924 loss_cnaBRCA18 1036 PLX4720 BRAF 12 31 2.30258509299405 NA 4.71864589228719 4.54937817743722 0.169267714849966 0.805706255544646 1.32778175014708 0.139887388174174 0.210086137081738 0.127481579582802 0.682886432301288 NA NA NA 0.614748184719713 99.482402686627 a7925 loss_cnaBRCA57 1241 CHIR-99021 GSK3B 5 41 2.30258509299405 NA 4.40223260929396 4.21066446848609 0.191568140807875 0.669707707872628 1.00955815045381 0.194776641984611 0.286047388369479 0.189754439327505 0.682934436287842 NA NA NA 0.590468599167792 99.482402686627 a7926 gain_cnaBRCA13_(FGFR1,WHSC1L1) 328 SNX-2112 HSP90 11 37 0.940007258491471 NA 0.194076056435457 0.483585981180022 -0.289509924744565 1.52947734894522 2.17448069372439 0.141115192912614 0.189286833796016 0.13313980003598 0.683044004730204 NA NA NA 0.62442293837877 99.482402686627 a7927 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 190 Bleomycin DNA damage 15 33 4.15888308335967 NA 2.32113448806818 1.96806491462998 0.353069573438203 2.47956442426803 2.87311748856392 0.12795672099269 0.142391772515623 0.122887273090485 0.683047639718537 NA NA NA 0.666850115154171 99.482402686627 a7928 gain_cnaBRCA48 1049 PD-173074 FGFR1, FGFR3 4 39 0.693147180559945 NA 2.71262223669005 2.96085545176682 -0.248233215076767 1.46575111860141 1.12140576917335 0.215835638550239 0.169355637479319 0.22135896024483 0.683137551997801 NA NA NA 0.7615732528471 99.482402686627 a7929 gain_cnaBRCA48 1149 TW 37 BCL2, BCL2L1 5 38 1.6094379124341 NA -0.359238643122079 -0.113850768516582 -0.245387874605497 0.893429713586386 1.28809174281754 0.195518325716458 0.274658286907054 0.190504966726004 0.68322098599133 NA NA NA 0.604619586102213 99.482402686627 a7930 gain_cnaBRCA15 281 CH5424802 ALK 22 26 1.63315443905142 NA 3.50629937780213 3.63357368225478 -0.127274304452653 1.22070770194328 0.926953827952789 0.11882576992209 0.104262719281644 0.137303823140515 0.683568785473183 NA NA NA 0.69068565065374 99.482402686627 a7931 ARID1A_mut 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 5 43 0.246860077931526 2.32630161961136 0.0234910140925716 -0.298491741765231 0.321982755857803 0.943571941208885 1.71573444630173 0.193628990895262 0.341238162980223 0.187664680016093 0.683856924307815 NA NA NA 0.535862925339678 99.482402686627 a7932 gain_cnaBRCA9_(KRAS) 282 EKB-569 EGFR 4 43 0.916290731874155 2.99573227355399 1.99522948420838 1.53926168162838 0.455967802579996 0.848160738573633 2.19129515089334 0.214241475915217 0.537595978973048 0.208081418148582 0.683864792704246 NA NA NA 0.423937843040364 99.482402686627 a7933 ASH1L_mut 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 3 40 0.693147180559945 NA 3.12802549938062 2.89194818307619 0.236077316304423 0.326952220567578 0.983531616453344 0.245413499212138 0.722054482133812 0.240030226131141 0.683960396558295 NA NA NA 0.374872502536839 99.482402686627 a7934 loss_cnaBRCA20 1050 ZM-447439 AURKB 3 36 1.38629436111989 0.693147180559945 2.58605433768323 2.91307989354873 -0.327025555865497 1.27029206780869 1.32958004558454 0.246543232970673 0.257441232731327 0.245961540225825 0.683971979885239 NA NA NA 0.705060397279813 99.482402686627 a7935 gain_cnaBRCA15 1026 17-AAG HSP90 20 23 0 NA -1.01669580963058 -0.79143346813478 -0.225262341495802 1.36968550020797 2.09860775653272 0.125289126820144 0.16446282118165 0.107338944495267 0.684095552240342 NA NA NA 0.675575832618207 99.482402686627 a7936 POLR2B_mut 172 Embelin XIAP 3 45 3.46573590279973 NA 2.77026255127443 3.00791548836475 -0.237652937090319 1.12946146391808 0.965678678929283 0.244154053771122 0.210412612277983 0.24609939338603 0.684103450496468 NA NA NA 0.753204191253548 99.482402686627 a7937 TP53_mut 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 38 11 1.63315443905142 NA 3.54503332929941 3.68590195437334 -0.140868625073933 1.06547245208284 0.743283250180654 0.140083574373779 0.132212357812308 0.189522130412189 0.684291758507104 NA NA NA 0.623351095230001 99.482402686627 a7938 loss_cnaBRCA42 292 Masitinib KIT 3 45 2.99573227355399 NA 4.26082046897475 3.99362784221811 0.267192626756646 0.774478675728442 1.10819063772644 0.243834119777371 0.344996750885795 0.241107096252697 0.684494386066282 NA NA NA 0.620040656951112 99.482402686627 a7939 gain_cnaBRCA47_(EGFR) 326 GSK690693 AKT 7 41 2.32630161961136 NA 3.21665346866752 2.89227272545798 0.324380743209537 1.25690968012289 2.02363667819625 0.167130539833333 0.258078005396395 0.160295939831783 0.684675886493132 NA NA NA 0.580066363950975 99.482402686627 a7940 gain_cnaBRCA14_(RAD21) 186 Bexarotene Retinioic acid X family agonist 20 27 2.07944154167984 NA 3.52500174375872 3.66322303146629 -0.138221287707574 1.40244976901666 0.91601050513219 0.120523083976854 0.098557032673255 0.150894871765283 0.684826179125047 NA NA NA 0.703470567956014 99.482402686627 a7941 MLL3_mut 1143 HG-5-88-01 EGFR, ADCK4 3 23 2.30258509299405 NA 4.31345274631637 4.56285413009175 -0.249401383775379 1.14057710082872 0.974173708837376 0.25214714313581 0.218662450433355 0.256013256683992 0.6848903111137 NA NA NA 0.746898233541976 99.482402686627 a7942 NF1_mut 1262 UNC1215 LMBL3 5 41 0 NA 2.86057906626155 2.74495216881941 0.115626897442142 0.295524147575462 0.619733357776428 0.193494167980022 0.391260404236905 0.186575235932119 0.684905902089867 NA NA NA 0.497807229588983 99.482402686627 a7943 gain_cnaBRCA61_(NOTCH2) 197 Bryostatin 1 PRKC 3 45 -4.8283137373023 NA -3.02843680696588 -2.79202839749888 -0.236408409467007 0.916012687549756 0.974463264865743 0.243219772651897 0.258084208527042 0.242603716313081 0.685245317380825 NA NA NA 0.703342680172367 99.482402686627 a7944 loss_cnaBRCA18 1495 AZD-2281 PARP1, PARP2 15 30 2.30258509299405 NA 4.09648471839982 3.94979458623307 0.146690132166746 0.971212550304443 1.20872115591602 0.129031683177906 0.151038134876618 0.121359778844591 0.685273377866895 NA NA NA 0.663325519747222 99.482402686627 a7945 gain_cnaBRCA8_(CHD4,WNK1) 176 IPA-3 PAK1, PAK2, PAK3 3 44 3.46573590279973 NA 4.15097332350836 4.52042123135561 -0.369447907847253 2.02384161882132 1.49066293126477 0.24332345096047 0.182547835962786 0.247841346355738 0.685371518453196 NA NA NA 0.783720813016342 99.482402686627 a7946 CDH1_mut 1053 MK-2206 AKT1, AKT2 4 38 1.38629436111989 0.693147180559945 1.07267243219081 1.4276902760716 -0.355017843880786 2.43246912898812 1.57600513839079 0.214424211169658 0.145949578413959 0.225264394913892 0.685510435894547 NA NA NA 0.792291494154525 99.482402686627 a7947 loss_cnaBRCA20 260 NG-25 MAP3K7 (TAK1) 3 46 2.32630161961136 NA 2.91386325412387 3.2275486318852 -0.313685377761332 0.49971594596374 1.31668645745526 0.242699501943486 0.627727372510328 0.238238478101754 0.685639595759192 NA NA NA 0.4159462477905 99.482402686627 a7948 loss_cnaBRCA36_(FAT1,IRF2) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 9 34 0.693147180559945 NA 1.47877893946156 1.73572680811039 -0.256947868648823 1.96306456196436 1.60641900435644 0.15276718255105 0.130891196156944 0.159950715194483 0.68574097843287 NA NA NA 0.724276480093145 99.482402686627 a7949 loss_cnaBRCA33 45 Z-LLNle-CHO g-secretase 4 8 0.940007258491471 NA 1.24121005203521 0.841678450795807 0.399531601239404 1.02372247215285 1.74759948470225 0.255132945683934 0.390273352502661 0.228617371850206 0.685750529983767 NA NA NA 0.629861400786426 99.482402686627 a7950 loss_cnaBRCA18 151 QS11 ARFGAP 16 32 2.32630161961136 NA 3.88423464368652 3.69855751729013 0.185677126396388 1.42856388502143 1.51789145357626 0.124669765187067 0.129974674806793 0.122325694606765 0.685771894686512 NA NA NA 0.680453161957219 99.482402686627 a7951 loss_cnaBRCA38 1030 KU-55933 ATM 3 39 2.30258509299405 NA 4.01181113106092 4.23849075689304 -0.226679625832118 0.147764479618484 0.951925817312642 0.244158794487049 1.53406032638823 0.238127406263707 0.685804646836883 NA NA NA 0.207326540402653 99.482402686627 a7952 loss_cnaBRCA34 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 5 44 1.63315443905142 NA 3.40319185740907 3.59636883464634 -0.193176977237274 0.9206475278432 1.01316489593928 0.192096911806151 0.209827291547537 0.190666867764092 0.685828801205399 NA NA NA 0.677805164060569 99.482402686627 a7953 loss_cnaBRCA22_(SYNCRIP,ZNF292) 136 Mitomycin C DNA crosslinker 18 30 2.77258872223978 NA -0.0215351917977107 -0.201967342068332 0.180432150270621 1.49511829685911 1.48246086164517 0.121327377610704 0.120680852244044 0.121711240369871 0.685936235510788 NA NA NA 0.687121719796524 99.482402686627 a7954 loss_cnaBRCA23 265 Tubastatin A HDAC6 3 46 2.99573227355399 NA 4.45485536928044 4.70720976227572 -0.252354392995282 0.459085482866189 1.05936218918959 0.242439918414383 0.549689333280087 0.238213517124237 0.685957329782578 NA NA NA 0.462745985719573 99.482402686627 a7955 gain_cnaBRCA9_(KRAS) 288 KIN001-055 JAK3, MNK1 4 45 2.32630161961136 NA 4.17134255549018 4.35391049488167 -0.182567939391491 0.65243417507157 0.872445303900529 0.212267276273318 0.279825837405688 0.209260040228616 0.685973984491083 NA NA NA 0.630459680777995 99.482402686627 a7956 loss_cnaBRCA33 110 Roscovitine CDKs 4 9 2.77258872223978 NA 4.26106426438464 3.99956161198357 0.26150265240107 0.930588600293431 1.08897367168101 0.249488772175227 0.28100779691328 0.240136799632076 0.68599694340188 NA NA NA 0.671399491600826 99.482402686627 a7957 loss_cnaBRCA29_(MAP2K4) 153 Midostaurin KIT 7 40 -0.669430653942629 NA 0.404534101734516 0.648522808042709 -0.243988706308193 1.6578248775197 1.43202834531033 0.166642122844737 0.147173992631374 0.170379802262446 0.686128457857182 NA NA NA 0.724129358048258 99.482402686627 a7958 loss_cnaBRCA22_(SYNCRIP,ZNF292) 9 MG-132 Proteasome 4 10 0 NA 0.613349217664503 0.215446132740696 0.397903084923807 1.98857155690494 1.48322598034723 0.244958600606613 0.200094929217992 0.268268686091013 0.686138159055808 NA NA NA 0.734079262861552 99.482402686627 a7959 gain_cnaBRCA19 136 Mitomycin C DNA crosslinker 4 44 2.77258872223978 NA -0.423622344900835 -0.108003734881941 -0.315618610018894 1.32019614371968 1.49811274759537 0.212229309472983 0.239069483364519 0.210677474392695 0.686341922388548 NA NA NA 0.675974867070485 99.482402686627 a7960 POLR2B_mut 150 Bicalutamide ANDR (androgen receptor) 3 45 0.0237165266173161 NA 2.62018855909221 2.77208102241007 -0.151892463317857 0.482309394060709 0.632853411147275 0.24222954696009 0.314927441157693 0.240012079641788 0.686456370253465 NA NA NA 0.647815438254669 99.482402686627 a7961 TP53_mut 1033 Vismodegib SMO 35 10 2.30258509299405 NA 4.78524848700418 4.67061585905383 0.114632627950352 0.727677771641984 0.980071498075907 0.145615349891505 0.157532128117212 0.11696353600263 0.686681755968629 NA NA NA 0.736965381502976 99.482402686627 a7962 gain_cnaBRCA15 1129 PF-4708671 RPS6KB1 (p70S6KA) 21 22 2.30258509299405 NA 3.88200557598918 3.73924820946024 0.142757366528947 1.16466430562589 1.14048026374314 0.123884679678755 0.122573831652056 0.125173026721573 0.686800468236015 NA NA NA 0.686958286820018 99.482402686627 a7963 gain_cnaBRCA31 225 Genentech Cpd 10 AURKA, AURKB 16 33 2.32630161961136 NA 3.15314144657058 2.95257108340488 0.200570363165701 1.37255499732718 1.72779124471613 0.123588525702881 0.14612919959949 0.11608483593089 0.686809518254931 NA NA NA 0.662829832624124 99.482402686627 a7964 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 202 GSK-1904529A IGF1R 9 39 0.0237165266173161 NA 2.29179414769844 2.1661083350267 0.125685812671744 0.407886773878291 0.902443322838341 0.150040910591979 0.308138975619856 0.139272804719127 0.686818356163048 NA NA NA 0.531470655177885 99.482402686627 a7965 loss_cnaBRCA18 83 JW-7-52-1 MTOR 5 7 0.182321556793955 NA -2.3377855879323 -1.79286513118014 -0.544920456752164 1.42923840192843 2.64997932293157 0.242955387196447 0.381266313595351 0.205631965516372 0.686958053890526 NA NA NA 0.656801759705641 99.482402686627 a7966 BRCA2_mut 254 AC220 FLT3 6 42 0.0237165266173161 NA 2.08624303093013 2.24340744952597 -0.157164418595841 0.879466005811434 0.88945453758013 0.176912394119284 0.17870437010335 0.176697528603796 0.687094137461008 NA NA NA 0.695662106391973 99.482402686627 a7967 loss_cnaBRCA60 344 THZ-2-49 CDK9 3 46 2.99573227355399 NA 1.44935739388412 1.80718266503772 -0.357825271153602 0.846251735516718 1.5042289609713 0.241416249476789 0.42283549461215 0.237879525283537 0.687210873689356 NA NA NA 0.554005117999902 99.482402686627 a7968 gain_cnaBRCA8_(CHD4,WNK1) 1161 ZG-10 IRAK1 3 23 2.30258509299405 NA 1.66183416907422 2.01631187002706 -0.354477700952837 0.867889105188175 1.45716417248425 0.250082003867421 0.40843662955762 0.243265451928114 0.687325780455639 NA NA NA 0.580399846484652 99.482402686627 a7969 loss_cnaBRCA38 1007 Docetaxel Microtubules 3 42 -4.38202663467388 NA -4.23630671253208 -4.61234915145537 0.376042438923294 1.62045696578133 1.54960713005992 0.242143399309316 0.232059503500594 0.242669533218239 0.687351573533892 NA NA NA 0.730518858975329 99.482402686627 a7970 loss_cnaBRCA38 1058 GDC0941 PI3K (class 1) 3 40 1.38629436111989 0.693147180559945 1.66096830614258 1.32238013930066 0.338588166841927 2.13453170523866 1.34676085365444 0.242620898591633 0.158624098208965 0.25140927279195 0.687358747748922 NA NA NA 0.810684746003358 99.482402686627 a7971 loss_cnaBRCA22_(SYNCRIP,ZNF292) 292 Masitinib KIT 18 30 2.99573227355399 NA 4.09297035201452 3.96074159901592 0.132228752998599 1.22407434614736 1.01314538610373 0.120664587306721 0.108023465580154 0.130513107804905 0.687558254164007 NA NA NA 0.702281943329476 99.482402686627 a7972 gain_cnaBRCA58_(CCND1) 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 5 21 2.30258509299405 NA 2.8952427210375 2.64304257682471 0.252200144212789 1.28437200326906 1.23740668775522 0.202512287413112 0.196360667758932 0.203813464650256 0.687638899836091 NA NA NA 0.705066654738243 99.482402686627 a7973 loss_cnaBRCA60 1199 Tamoxifen ER 3 44 1.6094379124341 NA 4.08568442650766 3.85440789018782 0.231276536319839 0.721025285359328 0.968397695532624 0.241224734117892 0.320760646007832 0.23882392263711 0.687937146976805 NA NA NA 0.642635177468959 99.482402686627 a7974 ARID1A_mut 329 QL-XI-92 DDR1 5 43 2.32630161961136 NA 4.41619824721734 4.23439752272467 0.181800724492669 0.738897549295021 0.970022201264236 0.190936228078346 0.246043209462698 0.18741913768131 0.688013152738856 NA NA NA 0.634230861422117 99.482402686627 a7975 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1164 XMD8-92 MAP2K5 (ERK5) 5 21 2.30258509299405 NA 4.09950691087644 3.83329424290617 0.266212667970268 1.93632188000415 1.15344015697817 0.202188811987514 0.137483685289812 0.230798855371659 0.68810997680709 NA NA NA 0.78043509665093 99.482402686627 a7976 POLR2B_mut 1001 AICAR AAPK1 (AMPK) agonist 3 42 7.60090245954208 NA 7.4253311978125 7.76085130269167 -0.335520104879171 1.95626016927402 1.35561997279784 0.241498348818938 0.171510983124338 0.247503069895539 0.688139118435925 NA NA NA 0.796124379574314 99.482402686627 a7977 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 8 37 0.693147180559945 NA 0.812656827211857 0.585117483467889 0.227539343743968 1.44668624593606 1.44423242790304 0.157506767717054 0.15728313197361 0.157550363326452 0.688243925013112 NA NA NA 0.694864130684405 99.482402686627 a7978 gain_cnaBRCA47_(EGFR) 295 NVP-BHG712 EPHB4 7 42 2.32630161961136 NA 4.06127140567114 3.85761439341365 0.203657012257493 0.881634512870791 1.27960288926886 0.164777138325588 0.230999364571541 0.159156417952337 0.688322770220658 NA NA NA 0.609696462565061 99.482402686627 a7979 BRCA1_mut 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 39 1.6094379124341 NA 2.25691638124968 2.59917986090816 -0.342263479658475 0.737421562468408 1.66346443083327 0.212082128597289 0.464135437690212 0.205753410361187 0.688345759798203 NA NA NA 0.477002199436123 99.482402686627 a7980 loss_cnaBRCA18 1164 XMD8-92 MAP2K5 (ERK5) 7 19 2.30258509299405 NA 3.71191038051415 3.94807057851647 -0.236160198002317 1.30617217466255 1.32014831235063 0.179361968707553 0.180803268193436 0.178889141313081 0.688581329514728 NA NA NA 0.69138644709095 99.482402686627 a7981 ARID1A_mut 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 5 41 1.63315443905142 NA 1.66375710313613 1.96986788488188 -0.306110781745749 1.78606591264028 1.5822428511328 0.191098964362206 0.171388289524677 0.19346637055531 0.688593838863797 NA NA NA 0.729864534124069 99.482402686627 a7982 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 152 CP466722 ATM 6 43 2.77258872223978 NA 2.56557580781805 2.75310445177387 -0.18752864395582 0.473928575604816 1.11721857812586 0.175691615931037 0.395689674792242 0.167853137808002 0.688668615247602 NA NA NA 0.478393762794272 99.482402686627 a7983 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 8 38 0 NA 0.921553953387357 0.596722764797035 0.324831188590323 1.6200154831423 2.14699276940395 0.156761253917429 0.200511162992255 0.15129589312986 0.688905506711382 NA NA NA 0.636163469991111 99.482402686627 a7984 TP53_mut 1016 Temsirolimus MTOR 34 10 -1.6094379124341 NA -1.8006223149059 -1.5820243494272 -0.218597965478704 1.62061937313513 0.99110466078357 0.144957843094524 0.13488544509734 0.220559920791695 0.68902639561 NA NA NA 0.606453715546877 99.482402686627 a7985 gain_cnaBRCA62 298 OSI-930 KIT, VEGFR, PDGFR 10 38 2.32630161961136 NA 3.81377759757178 3.93957511193445 -0.125797514362673 0.933802924723766 0.865084711306385 0.143122097258092 0.134715271319038 0.145416411501139 0.689036915853521 NA NA NA 0.706466045013431 99.482402686627 a7986 gain_cnaBRCA63 104 Bortezomib Proteasome 3 11 -3.91202300542815 NA -4.95083237782625 -4.46850051438056 -0.482331863445681 1.45177310614091 1.86931320707695 0.267007184907063 0.332236395209037 0.25802624280385 0.68907664452143 NA NA NA 0.657605154084507 99.482402686627 a7987 loss_cnaBRCA36_(FAT1,IRF2) 1021 Axitinib PDGFR, KIT, VEGFR 8 37 0.693147180559945 NA 2.31029531246323 2.49522895211685 -0.184933639653614 1.45566750735024 1.11559585816831 0.157033842371647 0.127043874181302 0.165771178065555 0.689129377910095 NA NA NA 0.74287880659868 99.482402686627 a7988 loss_cnaBRCA29_(MAP2K4) 279 BIX02189 MAP2K5 (MEK5) 7 42 2.99573227355399 NA 4.89987271120931 5.0486032667679 -0.148730555558586 0.826284258903226 0.91609713185659 0.164319911319514 0.179999260491789 0.16235238642999 0.689140993871332 NA NA NA 0.675000362425988 99.482402686627 a7989 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 8 35 0.693147180559945 NA 3.03195980257657 2.88018072573077 0.151779076845798 1.0829566070766 0.935191054931123 0.157770018342486 0.140152500898001 0.162297400136036 0.689337078251171 NA NA NA 0.722059138976896 99.482402686627 a7990 gain_cnaBRCA58_(CCND1) 231 FMK RSK 10 39 2.99573227355399 2.32630161961136 5.65692446269539 5.57187206523214 0.0850523974632518 0.621306004352636 0.590833971200939 0.142516579022183 0.136892926943256 0.143953126612495 0.689456559993707 NA NA NA 0.702605236685454 99.482402686627 a7991 ARID1A_mut 1006 Cytarabine DNA synthesis 5 40 0.693147180559945 NA 0.947684265641123 1.24113940093808 -0.293455135296959 1.6209893427646 1.52915654926692 0.190811704608187 0.181034586443653 0.19190653529728 0.689480717868118 NA NA NA 0.716964259576624 99.482402686627 a7992 loss_cnaBRCA34 1262 UNC1215 LMBL3 5 41 0 NA 2.65603849932222 2.76989614039738 -0.113857641075159 0.194260130655893 0.623758304691944 0.190522461301072 0.586109155238049 0.182534870026924 0.689482639408894 NA NA NA 0.394790157576338 99.482402686627 a7993 gain_cnaBRCA16 9 MG-132 Proteasome 3 11 0 NA 0.669377413965007 0.236338723288178 0.433038690676829 2.6403759628231 1.33154267568438 0.266545374696116 0.164006450889601 0.325215780601442 0.6895828989306 NA NA NA 0.806429953292355 99.482402686627 a7994 loss_cnaBRCA18 41 S-Trityl-L-cysteine KIF11 5 7 1.63315443905142 NA 1.46002799231912 1.05565860138432 0.404369390934805 1.33838716407722 1.87262015608152 0.24077559424187 0.302131850773991 0.215937754179124 0.689597712294155 NA NA NA 0.671939632354413 99.482402686627 a7995 NF1_mut 177 GSK-650394 SGK3 5 42 2.77258872223978 NA 4.30433727137449 3.97992708978821 0.324410181586276 0.889219873296834 1.76559022652466 0.190156272878421 0.364825608747931 0.183740358726858 0.689624059619751 NA NA NA 0.518922399439893 99.482402686627 a7996 loss_cnaBRCA33 1067 CCT007093 PPM1D 5 41 1.88706964903238 NA 3.91735001562559 4.10615893223317 -0.188808916607583 0.616357762643954 1.0216205899511 0.190399483281939 0.306330070051622 0.184813147331555 0.689672293275002 NA NA NA 0.571815036384949 99.482402686627 a7997 BRCA2_mut 1066 AZD6482 PI3Kbeta 4 39 1.6094379124341 NA 1.68996764603141 1.99562045766652 -0.30565281163511 1.10129152224753 1.47171924536792 0.211110691897838 0.277540329204867 0.207684184736402 0.68969619595458 NA NA NA 0.635557529263848 99.482402686627 a7998 BRCA2_mut 345 KIN001-270 CDK9 6 43 2.99573227355399 NA 5.00096084107236 5.12246505521446 -0.121504214142108 0.317366238810975 0.726191979889413 0.17501776139549 0.382851731795192 0.167316932033058 0.689798579478996 NA NA NA 0.487572688331092 99.482402686627 a7999 loss_cnaBRCA17 127 GSK269962A ROCK1, ROCK2 4 10 0.916290731874155 NA 2.66358325588158 2.3898714473377 0.273711808543878 0.705010001250558 1.24166398572297 0.241876736228301 0.38823819244885 0.220439516399848 0.689854669252781 NA NA NA 0.615290062756946 99.482402686627 a8000 gain_cnaBRCA58_(CCND1) 150 Bicalutamide ANDR (androgen receptor) 9 39 0.0237165266173161 NA 2.83822830113937 2.7451322301404 0.0930960709989717 0.482064074146231 0.653529313776421 0.148458168400332 0.193119703358628 0.142451255110525 0.689944052528606 NA NA NA 0.634068163822171 99.482402686627 a8001 loss_cnaBRCA17 295 NVP-BHG712 EPHB4 11 38 2.32630161961136 NA 3.75503293894982 3.92482479038482 -0.169791851435001 0.923665122552728 1.30764648651704 0.137374328758558 0.183824036752355 0.1298453773139 0.690067687543185 NA NA NA 0.632283017578816 99.482402686627 a8002 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1021 Axitinib PDGFR, KIT, VEGFR 7 38 0.693147180559945 NA 2.29816077721779 2.49259758651328 -0.194436809295494 1.4952449929987 1.11771566537451 0.165101265739376 0.130036756655879 0.17395909829209 0.690108466059784 NA NA NA 0.752428530983357 99.482402686627 a8003 gain_cnaBRCA30_(CRNKL1,FOXA2) 282 EKB-569 EGFR 5 42 0.916290731874155 2.99573227355399 1.21704467432693 1.62104635417189 -0.404001679844961 3.38671920266178 1.96297912760298 0.189809919348632 0.119289984102442 0.205810481713217 0.690159085109652 NA NA NA 0.805647330097444 99.482402686627 a8004 PTEN_mut 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 9 39 0.246860077931526 2.32630161961136 -0.465388289628682 -0.218697313302152 -0.246690976326529 1.42859729177017 1.70826799574153 0.148339903618045 0.172680557178472 0.144409997109057 0.690177829428891 NA NA NA 0.660241249732973 99.482402686627 a8005 loss_cnaBRCA7_(FAS,PTEN) 1069 EHT 1864 Rac GTPases 4 42 2.30258509299405 NA 3.72704951611903 3.54564761431922 0.181401901799807 0.86932307672242 0.863603356292259 0.20995723165623 0.208670293768964 0.210052335343655 0.690183907892704 NA NA NA 0.71247584496761 99.482402686627 a8006 loss_cnaBRCA28_(GPS2) 329 QL-XI-92 DDR1 4 44 2.32630161961136 NA 4.07055287873427 4.26995166359796 -0.199398784863689 0.663960904376841 0.969094663436124 0.20941292603431 0.300317057147867 0.205757798888996 0.690280267486279 NA NA NA 0.610025304105015 99.482402686627 a8007 gain_cnaBRCA31 1043 JNK Inhibitor VIII JNK 13 30 2.30258509299405 NA 4.72755743457709 4.82756647136952 -0.100009036792428 1.03894575212803 0.591959174251823 0.133193999578085 0.0962601142432927 0.168945834683328 0.690409040108041 NA NA NA 0.749555891745896 99.482402686627 a8008 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1021 Axitinib PDGFR, KIT, VEGFR 5 40 0.693147180559945 NA 2.66143881959769 2.43746599075102 0.223972828846674 0.827604463418324 1.20786970289594 0.190180220866198 0.270627864815495 0.185427971501964 0.690453278274256 NA NA NA 0.609005842301023 99.482402686627 a8009 gain_cnaBRCA62 1199 Tamoxifen ER 8 39 1.6094379124341 NA 3.99289561355133 3.8437906548558 0.149104958695523 1.32416028235686 0.874999809325229 0.155513642359655 0.112603406613384 0.170405704214391 0.690552365079649 NA NA NA 0.767789345297279 99.482402686627 a8010 TP53_mut 154 CHIR-99021 GSK3B 37 10 0.940007258491471 NA 3.30311926420819 3.1730119609341 0.13010730327409 0.986477584260577 0.510500846769134 0.142756922928847 0.131890785305186 0.254862071429491 0.690652004839927 NA NA NA 0.574023268951635 99.482402686627 a8011 loss_cnaBRCA20 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 3 44 2.32630161961136 NA 1.07196338551513 1.44045715497951 -0.36849376946438 0.840002128648391 1.56684420952514 0.23899716001041 0.438681947219951 0.235182136950334 0.69066436728747 NA NA NA 0.542777887044213 99.482402686627 a8012 loss_cnaBRCA17 333 T0901317 LXR 10 38 2.32630161961136 NA 4.64880539793636 4.7582337871069 -0.109428389170537 0.696773324821141 0.785489458495529 0.142311110581273 0.157050198783983 0.139312358666313 0.690704746033467 NA NA NA 0.673131440968482 99.482402686627 a8013 gain_cnaBRCA9_(KRAS) 269 NSC-207895 MDM4 4 45 2.99573227355399 NA 4.83307069536421 4.58357543986217 0.24949525550204 1.19268526888991 1.19486503417856 0.208830519738013 0.209187840254167 0.208806223602955 0.690785307637338 NA NA NA 0.711404283660482 99.482402686627 a8014 gain_cnaBRCA15 261 TL-1-85 MAP3K7 (TAK1) 22 27 2.32630161961136 NA 3.94761027191871 4.08770706848077 -0.140096796562059 1.54209034190187 0.874543632122886 0.114940629652556 0.0908486310790826 0.16019417604355 0.690828060216732 NA NA NA 0.706990517267254 99.482402686627 a8015 gain_cnaBRCA10_(MDM2,NUP107) 1230 IOX2 EGLN1 3 44 -2.30258509299405 NA 0.396505475356624 0.239437069374236 0.157068405982388 0.619584129563447 0.659437945128816 0.238808150149179 0.253506180174526 0.238185271476463 0.690895963937212 NA NA NA 0.708300489840183 99.482402686627 a8016 loss_cnaBRCA22_(SYNCRIP,ZNF292) 275 I-BET BRD2, BRD3, BRD4 19 30 2.99573227355399 NA 4.13705640252435 3.97680134197649 0.160255060547855 1.34125482217721 1.38281990647727 0.117226860378292 0.119481442227151 0.115890044536677 0.691099058967635 NA NA NA 0.689402110115538 99.482402686627 a8017 gain_cnaBRCA9_(KRAS) 184 BMS-754807 IGF1R 4 44 0.940007258491471 NA 1.30376496264321 1.65624204486503 -0.352477082221818 2.17793080417051 1.6488333637029 0.208763799372865 0.161840349356767 0.213773623206068 0.691189221046129 NA NA NA 0.771145250463946 99.482402686627 a8018 loss_cnaBRCA29_(MAP2K4) 158 PF-562271 FAK 5 40 0.940007258491471 NA 2.55194082654302 2.30591387793007 0.246026948612952 1.42146232233357 1.28348633124633 0.189697920220813 0.173080175779163 0.191686457910345 0.691196435505771 NA NA NA 0.727899604621236 99.482402686627 a8019 loss_cnaBRCA22_(SYNCRIP,ZNF292) 158 PF-562271 FAK 17 28 0.940007258491471 NA 2.23411878972769 2.39343713659097 -0.159318346863276 1.27683875389017 1.30871473340346 0.122841210879229 0.124775619770216 0.121736496729849 0.691485784463497 NA NA NA 0.690162581925448 99.482402686627 a8020 loss_cnaBRCA38 1009 ATRA Retinoic acid and retinoid X receptor agonist 3 42 2.30258509299405 NA 3.84650292432264 4.12450429639033 -0.278001372067687 1.25828374435959 1.1598342234204 0.23871019264826 0.220936949486841 0.239690609618199 0.691547209164129 NA NA NA 0.742337308966106 99.482402686627 a8021 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1020 Lenalidomide TNFA 5 40 1.6094379124341 NA 4.13436878295285 4.26977130112556 -0.135402518172713 0.740739567928606 0.712013356910142 0.189444558738805 0.182793688949749 0.190168508580101 0.691586953286743 NA NA NA 0.714769567092963 99.482402686627 a8022 loss_cnaBRCA20 294 MPS-1-IN-1 MPS1 3 46 2.99573227355399 NA 5.01975732381879 4.73934990159345 0.28040742222534 0.874079295393091 1.19082676643931 0.237818256593576 0.320803185366879 0.235472891715213 0.691623858265497 NA NA NA 0.64245108898768 99.482402686627 a8023 loss_cnaBRCA22_(SYNCRIP,ZNF292) 3 Rapamycin MTOR 4 10 -2.30258509299405 NA -3.20768702377898 -2.55605417881041 -0.651632844968572 3.7980595037786 2.23340913896423 0.240400898476375 0.171569940997575 0.291765997371523 0.691637428466755 NA NA NA 0.764390444698348 99.482402686627 a8024 gain_cnaBRCA48 305 TPCA-1 IKK 5 44 2.99573227355399 NA 4.41319639451167 4.15163658965252 0.26155980485915 0.80537144286997 1.43112443016128 0.188323112274096 0.324769157355608 0.18276524343147 0.691670773512111 NA NA NA 0.552256849651707 99.482402686627 a8025 loss_cnaBRCA34 330 XMD13-2 RIPK 5 43 2.32630161961136 NA 3.92773065011526 3.69698526690859 0.230745383206668 1.06743638903384 1.23752165519147 0.188568234168386 0.216167806884981 0.186457652873127 0.691676172650118 NA NA NA 0.670737142222828 99.482402686627 a8026 gain_cnaBRCA8_(CHD4,WNK1) 1378 Bleomycin (50 uM) DNA damage 3 45 3.91202300542815 NA 3.38989273574451 3.84090593833238 -0.451013202587876 1.93570827651337 1.89526252629355 0.237745881932057 0.232996473724981 0.237968722712993 0.691950295340114 NA NA NA 0.729418206660735 99.482402686627 a8027 gain_cnaBRCA13_(FGFR1,WHSC1L1) 219 AT-7519 CDK9 11 38 2.32630161961136 NA 1.86473707749198 1.61620833717202 0.248528740319965 2.01229448409858 1.76766601511183 0.136369428217066 0.123505154083496 0.140597114044896 0.692214837094228 NA NA NA 0.716386071408178 99.482402686627 a8028 loss_cnaBRCA34 1375 Temozolomide DNA akylating agent 5 41 3.40119738166216 NA 6.01823144821707 5.8857228240994 0.132508624117667 0.226076869936218 0.733123893604739 0.188672197932638 0.586121986539581 0.180745199104243 0.692338198819139 NA NA NA 0.397145823358496 99.482402686627 a8029 gain_cnaBRCA14_(RAD21) 282 EKB-569 EGFR 20 27 0.916290731874155 2.99573227355399 1.43449405063703 1.68441811978197 -0.249924069144944 2.44203064596324 1.86639406889848 0.117417124406835 0.102342724305314 0.133907449294696 0.692514608499988 NA NA NA 0.704537264699568 99.482402686627 a8030 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 290 KIN001-260 IKK 9 40 2.99573227355399 NA 5.16963716774365 5.01582184014686 0.153815327596789 0.84663109594584 1.08457059890583 0.146785383046522 0.181679279598098 0.141821406326122 0.692530952801133 NA NA NA 0.648245589337701 99.482402686627 a8031 ARID1A_mut 257 NPK76-II-72-1 PLK3 5 44 2.32630161961136 NA 3.74765353516381 3.44842697455762 0.299226560606184 1.46529591073562 1.60524294616575 0.187742809001195 0.204208964492342 0.186405778216257 0.692570796812531 NA NA NA 0.685701521673155 99.482402686627 a8032 loss_cnaBRCA20 1032 Afatinib ERBB2, EGFR 3 42 -0.693147180559945 NA 0.699658073590818 0.261244100166877 0.438413973423941 0.94036366088631 1.87624862008885 0.237843713352869 0.466217476981967 0.233665181005265 0.692607669380085 NA NA NA 0.523413235840497 99.482402686627 a8033 loss_cnaBRCA23 1243 piperlongumine Increases ROS levels 3 44 2.30258509299405 NA 1.90101857077606 1.69724003189909 0.20377853887697 0.120144676462747 0.878025992293903 0.237319855195395 1.6961095978327 0.232087137129716 0.692720637642842 NA NA NA 0.184101467269145 99.482402686627 a8034 gain_cnaBRCA8_(CHD4,WNK1) 1129 PF-4708671 RPS6KB1 (p70S6KA) 3 40 2.30258509299405 NA 3.55361623589692 3.82811822490518 -0.274501989008261 1.53149636725618 1.12956965514229 0.238193525401697 0.179237766982142 0.243014662936994 0.692759898768848 NA NA NA 0.787667346128926 99.482402686627 a8035 loss_cnaBRCA42 194 AUY922 HSP90 3 44 -1.36257783450257 NA -2.77959954030692 -2.36743895216558 -0.412160588141345 1.19642689386871 1.7590470906019 0.237158259422842 0.344492914906484 0.23430901329669 0.69291886786823 NA NA NA 0.621339316117343 99.482402686627 a8036 loss_cnaBRCA7_(FAS,PTEN) 271 VNLG/124 HDAC, RAR 4 45 1.63315443905142 NA 3.99595903567933 4.16526064518191 -0.169301609502583 1.04228012113332 0.800278836536764 0.207003593381824 0.162433885161788 0.211553275899738 0.693348206239088 NA NA NA 0.77036233628686 99.482402686627 a8037 loss_cnaBRCA60 201 Epothilone B Microtubules 3 45 -3.44201937618241 NA -3.83312965780132 -4.26259980923785 0.429470151436533 1.93377288487977 1.80955112280679 0.236605875351688 0.222089240569342 0.237335185518486 0.693349857086889 NA NA NA 0.740939621305147 99.482402686627 a8038 NF1_mut 1018 ABT-888 PARP1, PARP2 4 41 1.6094379124341 NA 4.52972785600391 4.39071993212125 0.139007923882653 0.563094090315003 0.675792382699596 0.207925595925845 0.246864469497256 0.205696198183467 0.693375880378478 NA NA NA 0.668488011398533 99.482402686627 a8039 BRCA2_mut 177 GSK-650394 SGK3 6 41 2.77258872223978 NA 3.75633136648427 4.05221063241638 -0.295879265932108 1.80255721443795 1.69365334673601 0.173424634629013 0.164144174488445 0.174698834624171 0.693418849429663 NA NA NA 0.71746141868933 99.482402686627 a8040 gain_cnaBRCA19 1072 BMS-708163 g-secretase 4 42 1.6094379124341 NA 3.86637773810654 3.66690424803609 0.199473490070448 0.714232348958547 0.976384235386069 0.207615084137947 0.279283751794928 0.204298147021571 0.693457840135363 NA NA NA 0.632982886397162 99.482402686627 a8041 loss_cnaBRCA34 1024 CEP-701 FLT3, JAK2, NTRK1, RET 5 40 0.693147180559945 NA 0.866775867636977 0.595418054195546 0.271357813441431 0.913955158660287 1.48851506169303 0.187824779779772 0.29690495301673 0.182301019603248 0.694085596902068 NA NA NA 0.583043845173571 99.482402686627 a8042 gain_cnaBRCA48 287 KIN001-244 PDPK1 (PDK1) 5 44 2.99573227355399 NA 3.6370780812972 3.46004103737537 0.177037043921838 0.942309946944093 0.948736366707496 0.186710292630587 0.187875597085617 0.186602991235836 0.69417328902487 NA NA NA 0.70728359693335 99.482402686627 a8043 loss_cnaBRCA34 1032 Afatinib ERBB2, EGFR 5 40 -0.693147180559945 NA 0.597941416466821 0.25203798363618 0.345903432830641 1.35001635046109 1.88664306560063 0.187651759838126 0.256221661843206 0.183343335651314 0.694352698732404 NA NA NA 0.625412030344457 99.482402686627 a8044 loss_cnaBRCA22_(SYNCRIP,ZNF292) 38 AZD-0530 SRC, ABL1 4 10 0.693147180559945 NA 2.70029442864705 2.54095620650215 0.159338222144891 0.426987365981419 0.732194322287917 0.238147135806901 0.373168470169268 0.217617396495237 0.694363618363166 NA NA NA 0.624181332200987 99.482402686627 a8045 loss_cnaBRCA17 151 QS11 ARFGAP 11 37 2.32630161961136 NA 3.91634178306016 3.71410365509748 0.202238127962685 1.56976959878748 1.46642922231302 0.135775435609722 0.128833000791261 0.137911959803755 0.694401425571503 NA NA NA 0.708536810650547 99.482402686627 a8046 gain_cnaBRCA8_(CHD4,WNK1) 204 Tipifarnib Farnesyl-transferase (FNTA) 3 45 2.77258872223978 NA 1.28359980185732 1.64240164254426 -0.358801840686933 1.77823946334009 1.5103324944789 0.235594910345552 0.201773635150909 0.237564802451481 0.694591902214736 NA NA NA 0.762747265518781 99.482402686627 a8047 loss_cnaBRCA17 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 10 38 2.32630161961136 NA 4.88073397190014 4.97895262231324 -0.0982186504131013 0.625332855546208 0.716927683284777 0.140322235311583 0.157066192095905 0.136999383205694 0.69480151292648 NA NA NA 0.674319195665557 99.482402686627 a8048 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 310 YM201636 FYV1 7 42 1.63315443905142 NA 2.27337327456424 2.43821651867197 -0.164843244107733 0.9890893979301 1.02771165460821 0.161158774333263 0.166661622753924 0.16039834069078 0.694808183817681 NA NA NA 0.695038624278719 99.482402686627 a8049 loss_cnaBRCA22_(SYNCRIP,ZNF292) 295 NVP-BHG712 EPHB4 19 30 2.32630161961136 NA 3.97426014361301 3.83125872114747 0.14300142246554 1.14132239593146 1.29135421860928 0.115692378744272 0.125294503091594 0.110737565576348 0.69493172311694 NA NA NA 0.68691058244218 99.482402686627 a8050 loss_cnaBRCA38 1021 Axitinib PDGFR, KIT, VEGFR 3 42 0.693147180559945 NA 2.72167025880951 2.44382911789526 0.277841140914252 0.11231265740693 1.20588304110024 0.235907527794545 2.47381860004952 0.230404717078327 0.69497956612445 NA NA NA 0.166339770208854 99.482402686627 a8051 gain_cnaBRCA8_(CHD4,WNK1) 154 CHIR-99021 GSK3B 3 44 0.940007258491471 NA 3.47632405151382 3.26174000523869 0.214584046275133 0.487828638786202 0.926439245559926 0.235434466133813 0.439875868725241 0.231622361966586 0.695034802558889 NA NA NA 0.542463260384383 99.482402686627 a8052 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1149 TW 37 BCL2, BCL2L1 5 38 1.6094379124341 NA 0.065958006154539 -0.169797696052979 0.235755702207518 1.15354632623923 1.26576907980394 0.187813901365946 0.20437471547079 0.186254906972475 0.695041460034742 NA NA NA 0.687658158273555 99.482402686627 a8053 gain_cnaBRCA62 1022 AZD7762 CHEK1, CHEK2 8 37 0.693147180559945 NA 1.11131593984759 0.860087927947245 0.251228011900342 2.15924131741786 1.50943688213946 0.153850487238707 0.116350131814249 0.166438235922959 0.695100959936687 NA NA NA 0.761812874003349 99.482402686627 a8054 loss_cnaBRCA22_(SYNCRIP,ZNF292) 106 XMD8-85 MAP2K5 (ERK5) 3 10 2.07944154167984 NA 2.96930457722684 3.30048064223056 -0.331176065003721 1.70987446149079 1.12308766622581 0.264850148154447 0.19368443266588 0.294879976838008 0.695144422507365 NA NA NA 0.776354739937232 99.482402686627 a8055 POLR2B_mut 306 TG101348 JAK2 3 45 2.32630161961136 NA 3.50940877851157 3.20592094186683 0.303487836644742 0.902734463925732 1.3055978053247 0.235134406814553 0.336187271863933 0.232451246016966 0.695157945925077 NA NA NA 0.628757954323696 99.482402686627 a8056 loss_cnaBRCA7_(FAS,PTEN) 273 CUDC-101 HDAC, EGFR 4 45 1.63315443905142 NA 0.271409783979874 -0.0531425819857801 0.324552365965654 1.42845591515483 1.58735475998988 0.205713582291282 0.227205027836282 0.204461141356784 0.695160080825983 NA NA NA 0.690194533523525 99.482402686627 a8057 loss_cnaBRCA24 1259 BMN-673 PARP1 3 43 2.30258509299405 NA 3.65033418766971 3.28148249534498 0.368851692324727 1.668095251538 1.56154751152168 0.23545511320477 0.221121480913421 0.236209074397802 0.695266037075574 NA NA NA 0.742162348223472 99.482402686627 a8058 gain_cnaBRCA15 173 FH535 unknown 22 26 3.46573590279973 NA 1.65264415275718 1.50560523110811 0.147038921649069 1.53235859914545 1.03853203543808 0.11418843195154 0.095955947733819 0.141583424132935 0.695266385048341 NA NA NA 0.704761458041642 99.482402686627 a8059 ASH1L_mut 1052 RO-3306 CDK1 3 40 1.6094379124341 NA 3.79102157987834 3.50577224421051 0.285249335667838 0.653829788888163 1.23090574303429 0.235906566990746 0.436274609257104 0.231739381574964 0.695556240612524 NA NA NA 0.547221961783684 99.482402686627 a8060 loss_cnaBRCA38 277 ABT-869 VEGFR and PDGFR family 4 44 0.0237165266173161 NA 2.60092605086603 2.69927390220277 -0.0983478513367433 0.392613904789466 0.483646550060312 0.205646196184007 0.250495079611307 0.203346537516868 0.695561100600452 NA NA NA 0.663786452410792 99.482402686627 a8061 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1091 BMS-536924 IGF1R 6 41 1.38629436111989 NA 2.85799557091219 3.04749343601627 -0.189497865104089 1.02193954881391 1.11055924327676 0.172104174934657 0.185429622842198 0.170632828686352 0.695632218768218 NA NA NA 0.687752470236883 99.482402686627 a8062 gain_cnaBRCA8_(CHD4,WNK1) 262 VX-11e ERK 4 45 1.63315443905142 NA 4.02912529640218 3.75438409111022 0.274741205291962 1.15597328018027 1.34985486892354 0.205288294427984 0.237670896034133 0.203533884728703 0.695757810165388 NA NA NA 0.678095205552285 99.482402686627 a8063 gain_cnaBRCA16 197 Bryostatin 1 PRKC 16 32 -4.8283137373023 NA -2.72873202644331 -2.84583987141419 0.117107844970882 1.19303876279081 0.844725557140334 0.120466829139704 0.0981592959284388 0.138634191875677 0.695810022969299 NA NA NA 0.728746960731796 99.482402686627 a8064 gain_cnaBRCA27_(CLTC,PPM1D) 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 7 19 2.30258509299405 NA 4.81416999207647 4.63849453166109 0.175675460415381 0.625610027047029 1.10175818768831 0.174955225950571 0.280806657215189 0.1594501065465 0.695821999083742 NA NA NA 0.617549494135739 99.482402686627 a8065 gain_cnaBRCA62 279 BIX02189 MAP2K5 (MEK5) 10 39 2.99573227355399 NA 4.92692084351603 5.05310866019376 -0.126187816677728 1.20300444537313 0.818954349913361 0.13940349216052 0.104893890594552 0.154084066701737 0.695887012543853 NA NA NA 0.75957780777305 99.482402686627 a8066 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1046 681640 WEE1, CHEK1 6 30 0.693147180559945 NA 2.47588704026713 2.66537645226771 -0.189489412000579 1.01618346925687 1.08470762908565 0.176284873195138 0.186471653725239 0.174691692876086 0.695906093318698 NA NA NA 0.691762697276637 99.482402686627 a8067 BRCA1_mut 1052 RO-3306 CDK1 4 39 1.6094379124341 NA 3.29922301228156 3.54889903740844 -0.249676025126873 0.736197296959942 1.23884465175553 0.20648519521931 0.339142816956659 0.201539413979844 0.696140299290349 NA NA NA 0.57663820331606 99.482402686627 a8068 loss_cnaBRCA7_(FAS,PTEN) 293 MP470 PDGFR 4 44 2.99573227355399 NA 3.84746237737671 3.50286906620727 0.344593311169436 2.01341108958176 1.6536553588597 0.205179995951993 0.171149008244023 0.208382786245772 0.696215766662235 NA NA NA 0.759258537926828 99.482402686627 a8069 gain_cnaBRCA62 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 8 38 2.30258509299405 NA 1.53957510813782 1.38656434836892 0.153010759768897 1.60825283086355 0.838409925673578 0.152813281207785 0.0951409858154816 0.182501131109544 0.696332312708454 NA NA NA 0.800302026355036 99.482402686627 a8070 loss_cnaBRCA24 295 NVP-BHG712 EPHB4 3 46 2.32630161961136 NA 4.15818033711213 3.86900355112467 0.289176785987467 0.339624029080456 1.2612080632264 0.233948707996247 0.851461502210026 0.22928555122594 0.69638200079754 NA NA NA 0.320254757594895 99.482402686627 a8071 loss_cnaBRCA57 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 4 39 1.6094379124341 NA 3.22944153487693 2.9168260910188 0.312615443858132 0.979001675247889 1.54976666027189 0.206304495970669 0.319320642407456 0.201717750079414 0.696392510152833 NA NA NA 0.594989844493945 99.482402686627 a8072 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1259 BMN-673 PARP1 15 31 2.30258509299405 NA 3.43593884748023 3.2424408758271 0.193497971653132 1.41689078298604 1.63172821171393 0.123516969029153 0.136565198938864 0.118584682341115 0.696428335187452 NA NA NA 0.682539621214352 99.482402686627 a8073 NF1_mut 1030 KU-55933 ATM 4 38 2.30258509299405 NA 4.39581857618147 4.20403417387593 0.191784402305533 1.05458279229137 0.917567967641067 0.206542783432698 0.181858080472591 0.209013837741724 0.696462830007537 NA NA NA 0.746365227197474 99.482402686627 a8074 PTEN_mut 274 PXD101, Belinostat HDAC 9 39 2.99573227355399 NA 0.848862770410497 0.630574248017107 0.218288522393391 1.75808212254994 1.44553010938818 0.145084789595036 0.124162870205849 0.151009322445577 0.696624210343294 NA NA NA 0.735765800781613 99.482402686627 a8075 CDH1_mut 238 CAL-101 PI3Kdelta 4 45 2.99573227355399 2.32630161961136 4.54025740221364 4.73484926985143 -0.194591867637792 1.20992847204954 0.930652715943517 0.204632670623081 0.160829232581134 0.209091817284937 0.696679651996261 NA NA NA 0.772550107285446 99.482402686627 a8076 loss_cnaBRCA57 1030 KU-55933 ATM 5 37 2.30258509299405 NA 4.37532047060096 4.20162082591909 0.173699644681865 0.697485908746423 0.950762104594108 0.18706576795229 0.249036779816888 0.182695170371793 0.696695850789548 NA NA NA 0.635703995390275 99.482402686627 a8077 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 166 FTI-277 Farnesyl transferase (FNTA) 9 38 0.0237165266173161 NA 2.34079135132152 2.22155552358306 0.119235827738466 0.493395468587341 0.874694102841487 0.145414750038067 0.241663807898064 0.136317173456552 0.696718836482964 NA NA NA 0.588649588841092 99.482402686627 a8078 loss_cnaBRCA22_(SYNCRIP,ZNF292) 196 Phenformin AAPK1 (AMPK) agonist 18 30 8.29404964010203 NA 7.06885856460536 7.2819057957175 -0.213047231112146 2.33164875061088 1.44233573992804 0.116912763686004 0.0913719234324332 0.147709874486488 0.69676775767042 NA NA NA 0.729576536761549 99.482402686627 a8079 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1008 Methotrexate Dihydrofolate reductase (DHFR) 15 30 -1.6094379124341 NA 0.591988242591834 0.727980990376876 -0.135992747785042 1.25803915313685 1.00927478296387 0.124026456406593 0.108098978832218 0.134743035376036 0.696843246111745 NA NA NA 0.71902898465177 99.482402686627 a8080 loss_cnaBRCA20 253 XMD14-99 EPHB3, CAMK1 3 45 2.32630161961136 NA 4.76270472272229 4.94446164805635 -0.181756925334063 1.07454204923023 0.761429014557357 0.233720304877845 0.1691482668959 0.238705016303751 0.696897233891302 NA NA NA 0.798781693631093 99.482402686627 a8081 gain_cnaBRCA12_(TERT) 1373 Dabrafenib BRAF 10 36 2.30258509299405 NA 4.39503285489803 4.16446587504527 0.230566979852766 1.15592841445589 1.74902400251556 0.140145579877579 0.1994647566141 0.131826081014983 0.696907046766351 NA NA NA 0.626832614744161 99.482402686627 a8082 loss_cnaBRCA18 1021 Axitinib PDGFR, KIT, VEGFR 14 31 0.693147180559945 NA 2.56479241445609 2.41608838469819 0.148704029757903 0.979530846481792 1.25399589489178 0.126257589476016 0.151811482294823 0.118584143986162 0.696921538575151 NA NA NA 0.669662071908934 99.482402686627 a8083 gain_cnaBRCA19 1239 YK 4-279 RNA helicase A 4 38 2.30258509299405 NA 1.77039890080453 2.03914803586988 -0.26874913506535 0.900606752566954 1.33068772933274 0.206196572096683 0.298408971839649 0.201962586068267 0.696945471677134 NA NA NA 0.61588824698014 99.482402686627 a8084 loss_cnaBRCA17 1164 XMD8-92 MAP2K5 (ERK5) 4 22 2.30258509299405 NA 3.64576989983566 3.92789245709406 -0.282122557258402 1.53890885975979 1.28207314422019 0.214229116360618 0.183326358457927 0.22005184222933 0.69696948172601 NA NA NA 0.748007482213711 99.482402686627 a8085 loss_cnaBRCA60 295 NVP-BHG712 EPHB4 3 46 2.32630161961136 NA 4.15759664715669 3.86904161786089 0.288555029295794 0.339688298748177 1.26121620645441 0.233444052389986 0.849470029904417 0.228791088965622 0.697003459413772 NA NA NA 0.321279137484742 99.482402686627 a8086 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 155 AP-24534 ABL 9 38 -0.669430653942629 NA 1.31128843905922 1.47711349503748 -0.165825055978264 0.987168357994813 1.17231425922636 0.14525719867394 0.167980521899118 0.14145102703749 0.697030621093662 NA NA NA 0.669308218436026 99.482402686627 a8087 gain_cnaBRCA19 1199 Tamoxifen ER 4 43 1.6094379124341 NA 3.68955331214709 3.88587877207438 -0.196325459927293 0.708336344936032 0.974298898425855 0.204747567012526 0.277164176779639 0.201504343527936 0.697141640637551 NA NA NA 0.635293098609454 99.482402686627 a8088 NF1_mut 1072 BMS-708163 g-secretase 5 41 1.6094379124341 NA 3.5253483353287 3.70362799251947 -0.178279657190771 1.2065776117 0.932699213751265 0.185547823610815 0.14775647704882 0.19114378415067 0.697170392215282 NA NA NA 0.763709396125571 99.482402686627 a8089 loss_cnaBRCA7_(FAS,PTEN) 207 AS601245 JNK 4 44 2.07944154167984 NA 2.50816051481164 2.24420436754494 0.263956147266702 1.01744066311234 1.30799928115513 0.204451604400347 0.259431490048042 0.20180144673596 0.697239085319191 NA NA NA 0.654050722087316 99.482402686627 a8090 gain_cnaBRCA63 266 Zibotentan, ZD4054 Endothelin A Receptor 7 42 2.99573227355399 NA 5.67420534626356 5.7533450575429 -0.0791397112793382 0.972602966134782 0.377883306646201 0.159779784333854 0.0813689799794124 0.209428968910325 0.697285944389077 NA NA NA 0.838328849600831 99.482402686627 a8091 gain_cnaBRCA64_(SDHC) 293 MP470 PDGFR 8 40 2.99573227355399 NA 3.74375973044155 3.48915026447736 0.254609465964189 1.42069367376348 1.72182723827361 0.151599345014436 0.179214893869217 0.147871668135226 0.697288396703801 NA NA NA 0.664099119969801 99.482402686627 a8092 loss_cnaBRCA18 1527 GDC0941 (rescreen) PI3K 14 31 1.38629436111989 NA 0.879595734711346 1.02629588952916 -0.14670015481781 1.15231067142944 1.16821608181103 0.126092763763509 0.127309551542926 0.125576215823349 0.697296963602467 NA NA NA 0.697100190852376 99.482402686627 a8093 loss_cnaBRCA38 1013 Nilotinib ABL 3 37 0.693147180559945 NA 2.99304909153522 3.21992291950316 -0.226873827967933 0.502922679184718 0.983839453391576 0.235218250298332 0.451110751926549 0.230600457407795 0.697369514137551 NA NA NA 0.538317327958064 99.482402686627 a8094 gain_cnaBRCA31 275 I-BET BRD2, BRD3, BRD4 16 33 2.99573227355399 NA 3.9292067822501 4.09214555731078 -0.162938775060683 1.47041784821892 1.31595537756268 0.119181409058016 0.110811205983419 0.123817857230438 0.697398393009833 NA NA NA 0.709722046679266 99.482402686627 a8095 TP53_mut 1032 Afatinib ERBB2, EGFR 35 10 -0.693147180559945 NA 0.232973613126069 0.491714996836888 -0.258741383710819 1.88956853411058 1.65739946685731 0.140361243649209 0.136931462945115 0.156112867709215 0.69739866734897 NA NA NA 0.678841464318008 99.482402686627 a8096 loss_cnaBRCA36_(FAT1,IRF2) 166 FTI-277 Farnesyl transferase (FNTA) 9 38 0.0237165266173161 NA 2.34054291852081 2.22161436293059 0.118928555590214 0.632967902838382 0.8550514432285 0.145038738140981 0.187890341764423 0.139089357175007 0.697463028779289 NA NA NA 0.644086308106662 99.482402686627 a8097 gain_cnaBRCA47_(EGFR) 312 AV-951 VEGFR 7 41 -2.05572501506252 NA 0.720446473554029 0.617222327051966 0.103224146502063 0.285533993523518 0.683247690218672 0.159932487151481 0.361512635424828 0.151078661486622 0.697549362024735 NA NA NA 0.504010315835974 99.482402686627 a8098 gain_cnaBRCA13_(FGFR1,WHSC1L1) 211 TL-2-105 CRAF 11 38 2.32630161961136 1.63315443905142 4.02118773028974 3.8746596856915 0.146528044598231 0.831725036379971 1.15544103165038 0.133862942361741 0.176173660992561 0.126815683868294 0.697581497934774 NA NA NA 0.644293031149557 99.482402686627 a8099 gain_cnaBRCA27_(CLTC,PPM1D) 1028 VX-702 p38 10 35 0.693147180559945 NA 3.50189810751521 3.40538381017331 0.0965142973418964 0.665626960362092 0.693933967053712 0.140260878603353 0.144997578357394 0.139082826211368 0.697604002165225 NA NA NA 0.694384736711057 99.482402686627 a8100 loss_cnaBRCA36_(FAT1,IRF2) 1072 BMS-708163 g-secretase 9 37 1.6094379124341 NA 3.79656491111047 3.65692986945805 0.139635041652423 0.880268798890763 0.97783692827313 0.145326843289178 0.158627730334619 0.142799926669797 0.697676070829309 NA NA NA 0.683100021436695 99.482402686627 a8101 loss_cnaBRCA20 1268 XAV 939 TNKS1 (tankyrase-1) 3 44 1.6094379124341 NA 3.86762735334358 3.64738464025109 0.220242713092488 0.156852480285937 0.966081500063429 0.23307394988379 1.40413918027304 0.227975293055532 0.69793629172095 NA NA NA 0.214026832822859 99.482402686627 a8102 loss_cnaBRCA17 1038 NU-7441 PRKDC (DNAPK) 6 37 0.693147180559945 NA 2.75211956558689 2.91568860217334 -0.163569036586451 1.13908956559115 0.921927982464302 0.17198429744908 0.143596290868984 0.177420622540638 0.697983953156608 NA NA NA 0.749243148549927 99.482402686627 a8103 gain_cnaBRCA15 1018 ABT-888 PARP1, PARP2 21 24 1.6094379124341 NA 4.44467943166432 4.36667335733484 0.0780060743294824 0.760655791217923 0.576698433587471 0.116673214556332 0.102551081882362 0.135263197862754 0.698121754700936 NA NA NA 0.70366432198961 99.482402686627 a8104 loss_cnaBRCA42 238 CAL-101 PI3Kdelta 3 46 2.99573227355399 2.32630161961136 4.92655430090362 4.70542573585779 0.221128565045834 0.425307551747661 0.967705556648336 0.232534847790858 0.519926260742796 0.228508107168173 0.698123629819643 NA NA NA 0.484676523657816 99.482402686627 a8105 loss_cnaBRCA18 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 12 31 1.6094379124341 NA 3.00549923180589 2.81471755761641 0.190781674189478 1.43278005907601 1.43814440053747 0.132790926665829 0.133154892114085 0.13265821854758 0.698132689015265 NA NA NA 0.699732136537801 99.482402686627 a8106 loss_cnaBRCA36_(FAT1,IRF2) 281 CH5424802 ALK 9 39 1.63315443905142 NA 3.44965990621183 3.60421956139396 -0.154559655182131 0.862405998172026 1.11026495607452 0.144274825388131 0.179219132879106 0.139209703356392 0.698231796901862 NA NA NA 0.654100049427558 99.482402686627 a8107 gain_cnaBRCA9_(KRAS) 1023 GW 441756 NTRK1 4 41 0.693147180559945 NA 2.60322220076576 2.33548821432193 0.267733986443831 0.761014449114397 1.34206722165816 0.204389683441496 0.351811961987577 0.199493722909825 0.698323279766386 NA NA NA 0.564349349014222 99.482402686627 a8108 gain_cnaBRCA58_(CCND1) 172 Embelin XIAP 9 39 3.46573590279973 NA 3.10710222770833 2.96674524566313 0.1403569820452 1.19894464258608 0.91906651921295 0.144172057788392 0.117067108071358 0.152716891662418 0.698435866366487 NA NA NA 0.748346707077111 99.482402686627 a8109 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 200 LAQ824 HDAC 6 42 0.0237165266173161 NA -2.89563930263018 -2.65429999663567 -0.241339305994508 1.08716939573333 1.45443906346177 0.170061431028073 0.221988686346085 0.165932909846416 0.698586505671167 NA NA NA 0.64079742513849 99.482402686627 a8110 gain_cnaBRCA8_(CHD4,WNK1) 310 YM201636 FYV1 4 45 1.63315443905142 NA 2.22375077770325 2.43163785767466 -0.207887079971401 1.32260673886716 0.999204747602616 0.20323167103712 0.1571798130633 0.208052534248044 0.698651080537174 NA NA NA 0.777377055915961 99.482402686627 a8111 PIK3CA_mut 178 BAY 61-3606 SYK 17 31 2.07944154167984 NA 2.97309693855926 3.16301572529644 -0.189918786737183 1.98113389053046 1.38248276136918 0.117519577224424 0.0958636807158605 0.137375157249044 0.698777922327889 NA NA NA 0.72845374722384 99.482402686627 a8112 loss_cnaBRCA34 1072 BMS-708163 g-secretase 4 42 1.6094379124341 NA 3.50549915898787 3.70127363652358 -0.195774477535715 1.00397081984838 0.957616758221007 0.203751702450034 0.195000167002146 0.204439276834933 0.698871137381522 NA NA NA 0.729618175582736 99.482402686627 a8113 BRCA2_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 41 1.38629436111989 NA 2.61360390795745 2.88848794348262 -0.274884035525164 1.38775663804049 1.50037750369925 0.184425166070234 0.198077982832279 0.183209915402907 0.698909828085149 NA NA NA 0.695113504644544 99.482402686627 a8114 gain_cnaBRCA61_(NOTCH2) 295 NVP-BHG712 EPHB4 3 46 2.32630161961136 NA 3.61763468208843 3.90425652862621 -0.286621846537779 0.714956412953597 1.25425114307121 0.23187503144729 0.400894154307532 0.228520299240825 0.69893697099041 NA NA NA 0.57304751852683 99.482402686627 a8115 gain_cnaBRCA10_(MDM2,NUP107) 1502 Bicalutamide ANDR (androgen receptor) 3 42 2.30258509299405 NA 4.68576638675406 4.54919861482001 0.136567771934049 0.562870150001479 0.588365846487504 0.232572742451867 0.242627490432189 0.232113697199365 0.699072041376945 NA NA NA 0.719939240077211 99.482402686627 a8116 MACF1_mut 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 3 40 1.6094379124341 NA 2.61745377494514 2.97054055911013 -0.353086784164995 0.397792130819573 1.55112037985722 0.233004564002318 0.887616312161653 0.227633386002894 0.699110803874366 NA NA NA 0.321989607948235 99.482402686627 a8117 loss_cnaBRCA38 304 SB52334 ALK5 4 45 2.99573227355399 NA 4.06327439752817 4.32310217895782 -0.259827781429658 0.804641381033893 1.30693367788773 0.202868156920949 0.322911283901162 0.198807166595931 0.699162946186616 NA NA NA 0.588632539902108 99.482402686627 a8118 PTEN_mut 157 JNK-9L JNK 8 39 1.63315443905142 NA -0.0771509270265281 0.0831253695906387 -0.160276296617167 1.3329535090026 1.00434028134281 0.150897073325133 0.120241475441327 0.15958365864095 0.699268952001662 NA NA NA 0.755147797367006 99.482402686627 a8119 gain_cnaBRCA19 283 GSK2126458 PI3K, MTOR 4 44 -2.05572501506252 0.0237165266173161 -3.36119251841623 -3.02755475724261 -0.333637761173613 1.61208115145451 1.64593661497909 0.202973554608669 0.206960897019723 0.202703894024407 0.69931734779655 NA NA NA 0.714745975039879 99.482402686627 a8120 gain_cnaBRCA9_(KRAS) 156 AZD6482 PI3Kbeta 4 43 1.63315443905142 NA 1.77992639299892 2.07874081673403 -0.298814423735105 0.137501765736478 1.52187243979111 0.203178775180675 2.17316790176922 0.19634656356358 0.699344929706479 NA NA NA 0.223443491234272 99.482402686627 a8121 gain_cnaBRCA62 127 GSK269962A ROCK1, ROCK2 5 9 0.916290731874155 NA 2.62864067711613 2.37887156792474 0.249769109191388 0.526604090249793 1.33561618879023 0.220621677682832 0.474301498632323 0.187006650029919 0.699386108520119 NA NA NA 0.629436851986547 99.482402686627 a8122 loss_cnaBRCA36_(FAT1,IRF2) 1005 Cisplatin DNA crosslinker 8 37 1.79175946922805 2.30258509299405 3.81828212118426 3.63804061761899 0.180241503565262 0.936134989382503 1.23348517290617 0.151444019044087 0.192537941225927 0.146123769887401 0.699628255474259 NA NA NA 0.650140471408922 99.482402686627 a8123 loss_cnaBRCA38 1026 17-AAG HSP90 3 40 0 NA -1.28510261201438 -0.867039453091711 -0.418063158922669 2.18591921289926 1.77615781622417 0.232475106336586 0.191252794913759 0.235375007279142 0.699760059531263 NA NA NA 0.774580997383357 99.482402686627 a8124 loss_cnaBRCA29_(MAP2K4) 1164 XMD8-92 MAP2K5 (ERK5) 3 23 2.30258509299405 NA 4.16359950798017 3.84808326658571 0.315516241394457 1.1397248578194 1.33194865571096 0.239571567872721 0.276835447809856 0.236883186181109 0.699774050112817 NA NA NA 0.690873754401842 99.482402686627 a8125 gain_cnaBRCA58_(CCND1) 268 YM155 BIRC5 (Survivin) 10 39 1.63315443905142 NA -3.41969075920362 -3.64067729499557 0.220986535791957 1.6247683677944 1.60347455787157 0.13746586184043 0.13601110174981 0.13781730100245 0.699900881924358 NA NA NA 0.706273591357764 99.482402686627 a8126 loss_cnaBRCA36_(FAT1,IRF2) 225 Genentech Cpd 10 AURKA, AURKB 9 40 2.32630161961136 NA 2.82849394859653 3.06071658400304 -0.232222635406512 1.32138988835507 1.67833649695144 0.143070650236454 0.175741193006702 0.138364765247211 0.699917528917488 NA NA NA 0.658254203706196 99.482402686627 a8127 loss_cnaBRCA33 1049 PD-173074 FGFR1, FGFR3 5 38 0.693147180559945 NA 2.75018597213051 2.96244530802668 -0.212259335896166 0.42179207658491 1.20298113582177 0.184515175258225 0.503232155555764 0.176444442539965 0.700126325699646 NA NA NA 0.446152654236678 99.482402686627 a8128 gain_cnaBRCA30_(CRNKL1,FOXA2) 1066 AZD6482 PI3Kbeta 3 40 1.6094379124341 NA 1.65454516323244 1.99063582358557 -0.336090660353128 1.71857816991412 1.43278102576895 0.232101740385249 0.195563208143114 0.234572243984564 0.700218042209582 NA NA NA 0.769897810441749 99.482402686627 a8129 ASH1L_mut 1006 Cytarabine DNA synthesis 3 42 0.693147180559945 NA 0.876002460454551 1.23228547581822 -0.356283015363669 2.16241715014288 1.50105745191633 0.231632828882745 0.164761463966436 0.237354682799662 0.700227154383875 NA NA NA 0.803849566515887 99.482402686627 a8130 gain_cnaBRCA16 172 Embelin XIAP 16 32 3.46573590279973 NA 3.07005416534469 2.95456618702256 0.115487978322124 1.19872339437571 0.84329296966104 0.118624648080539 0.0963424747226774 0.13694882143811 0.700227360732008 NA NA NA 0.733247060162547 99.482402686627 a8131 gain_cnaBRCA48 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 40 2.30258509299405 NA 2.96272643986412 3.20363454551288 -0.240908105648759 1.05026844560341 1.33440848756591 0.18381819056249 0.229377647835882 0.180535501605058 0.70028084916627 NA NA NA 0.657075403885379 99.482402686627 a8132 loss_cnaBRCA34 1010 Gefitinib EGFR 5 40 -0.693147180559945 NA 1.22861545832219 1.42130810922326 -0.192692650901071 0.619105846830745 1.08274409535195 0.183814200351994 0.311243468120162 0.177966937643225 0.700287029479787 NA NA NA 0.5712268255383 99.482402686627 a8133 gain_cnaBRCA63 133 Doxorubicin DNA intercalating 6 42 0.0237165266173161 NA -0.757631673542542 -1.06964688496129 0.312015211418744 2.39999585896829 1.7666483892341 0.169018080634716 0.130006562408351 0.176614211022496 0.700343068244023 NA NA NA 0.7697131236285 99.482402686627 a8134 loss_cnaBRCA22_(SYNCRIP,ZNF292) 152 CP466722 ATM 19 30 2.77258872223978 NA 2.65600544801029 2.77709475869964 -0.121089310689352 1.28897044576492 0.903156981100461 0.113430548600056 0.0939426587220881 0.134073381730172 0.70059576020523 NA NA NA 0.72318488072399 99.482402686627 a8135 MLL3_mut 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 3 46 1.63315443905142 NA 3.79425730076415 3.56246556759113 0.231791733173017 1.38217329139269 0.985736367490212 0.230456418512106 0.167700920439188 0.235145765964974 0.700686871373977 NA NA NA 0.800422025815726 99.482402686627 a8136 loss_cnaBRCA23 1219 PFI-1 BRD2, BRD3, BRD4 3 44 2.30258509299405 NA 3.38943767003126 3.15768856646464 0.231749103566624 1.11186280355856 0.998693298107033 0.230827187431744 0.208433183325229 0.232052326781297 0.700702203982756 NA NA NA 0.755752805034685 99.482402686627 a8137 gain_cnaBRCA14_(RAD21) 1161 ZG-10 IRAK1 13 13 2.30258509299405 NA 2.08350971290407 1.86731148077632 0.216198232127752 1.52687322102152 1.2997823864606 0.152479757329975 0.141595405008878 0.166334175920382 0.700889587140205 NA NA NA 0.700976371000346 99.482402686627 a8138 loss_cnaBRCA38 298 OSI-930 KIT, VEGFR, PDGFR 4 44 2.32630161961136 NA 4.07599956064905 3.8985825451507 0.177417015498356 0.783598780356328 0.885351382778731 0.201822518774326 0.226413082748391 0.200391639917612 0.700937415249964 NA NA NA 0.691751826089692 99.482402686627 a8139 loss_cnaBRCA60 312 AV-951 VEGFR 3 45 -2.05572501506252 NA 0.492873348902648 0.641569348384464 -0.148695999481815 0.615512284106591 0.646776746877027 0.230376093866358 0.24158088038429 0.229903131489802 0.701017016332601 NA NA NA 0.720779455280348 99.482402686627 a8140 loss_cnaBRCA24 341 EX-527 SIRT1 3 46 2.99573227355399 NA 5.49953472204466 5.65102835944964 -0.15149363740498 0.620812844768491 0.659994799720308 0.230102358814841 0.244024650394393 0.229537622825482 0.701123870552587 NA NA NA 0.718168923577644 99.482402686627 a8141 loss_cnaBRCA17 1024 CEP-701 FLT3, JAK2, NTRK1, RET 8 37 0.693147180559945 NA 0.80451501522889 0.58687787524799 0.2176371399809 1.73305952210787 1.38186568594742 0.150627953433435 0.125579726030526 0.157495147461952 0.7011660452452 NA NA NA 0.746712039243211 99.482402686627 a8142 gain_cnaBRCA12_(TERT) 310 YM201636 FYV1 9 40 1.63315443905142 NA 2.53356711885068 2.38791506591291 0.145652052937765 0.975583372535884 1.03238214353711 0.142386140442474 0.149297391733075 0.141083467831725 0.701281874441002 NA NA NA 0.695763300394206 99.482402686627 a8143 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 6 41 -2.30258509299405 NA -0.294062726507301 -0.118148705842807 -0.175914020664495 0.579876547367489 1.08763487468431 0.168582275590148 0.30336460659274 0.161739959575638 0.701548743339446 NA NA NA 0.558139043687065 99.482402686627 a8144 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 6 40 1.63315443905142 NA 1.70137371540491 1.9718781625852 -0.270504447180294 1.15301187826656 1.65086196684227 0.168843842583216 0.23460681739634 0.163856489890375 0.701602056273261 NA NA NA 0.62810931170003 99.482402686627 a8145 gain_cnaBRCA14_(RAD21) 1230 IOX2 EGLN1 21 26 -2.30258509299405 NA 0.290629163351744 0.216212886467294 0.0744162768844502 0.540855558493034 0.738136584011955 0.113128748734378 0.137589927136542 0.100816405115676 0.701620686283493 NA NA NA 0.692216749970917 99.482402686627 a8146 loss_cnaBRCA17 1218 JQ1 BRD2, BRD3, BRD4 9 37 0 NA 2.5394254795449 2.43817126476845 0.101254214776456 0.725426645801234 0.702150730078736 0.143330288906822 0.139578846962011 0.144205810004786 0.701622139302119 NA NA NA 0.712155301114672 99.482402686627 a8147 gain_cnaBRCA9_(KRAS) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 4 39 1.6094379124341 NA 3.22421393187629 2.91736225542912 0.306851676447169 0.701187256224428 1.56171978497119 0.202486879692856 0.437617303684931 0.196483184371535 0.701729042833354 NA NA NA 0.500208365163625 99.482402686627 a8148 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 166 FTI-277 Farnesyl transferase (FNTA) 6 41 0.0237165266173161 NA 2.36488930568525 2.22675356643752 0.138135739247727 0.587920104353205 0.844558516066597 0.168454283342211 0.234956651805087 0.163559702045363 0.70176411595458 NA NA NA 0.626985388926408 99.482402686627 a8149 gain_cnaBRCA47_(EGFR) 277 ABT-869 VEGFR and PDGFR family 7 41 0.0237165266173161 NA 2.62672886224638 2.70206472840637 -0.0753358661599934 0.357095716743426 0.49389180706193 0.157516482830131 0.210968271608036 0.152535160702811 0.701890771878129 NA NA NA 0.638000871039266 99.482402686627 a8150 loss_cnaBRCA33 1199 Tamoxifen ER 5 42 1.6094379124341 NA 3.71309768144988 3.88775028667946 -0.174652605229581 0.473247148063195 0.993674889373617 0.182134495775732 0.369051574730798 0.175764334086853 0.702056249704097 NA NA NA 0.520619717630358 99.482402686627 a8151 gain_cnaBRCA63 1066 AZD6482 PI3Kbeta 4 39 1.6094379124341 NA 2.23278568479144 1.93994681266549 0.292838872125946 1.31168104647293 1.45829042402962 0.202227528765727 0.223254634130287 0.200809706558149 0.702092139459746 NA NA NA 0.696685534476519 99.482402686627 a8152 loss_cnaBRCA7_(FAS,PTEN) 1241 CHIR-99021 GSK3B 4 42 2.30258509299405 NA 4.05059630935973 4.24871478611811 -0.19811847675838 0.834571118958291 0.993797949534099 0.201388913259864 0.237389567237447 0.199354885820865 0.702189677203287 NA NA NA 0.679705452174649 99.482402686627 a8153 loss_cnaBRCA22_(SYNCRIP,ZNF292) 228 KIN001-102 AKT1 19 30 2.32630161961136 NA 1.84601888718787 2.0055705782152 -0.159551691027336 1.46356864174017 1.38394703743451 0.112759778488633 0.109015516236827 0.115287425538411 0.702278818039933 NA NA NA 0.706357096279793 99.482402686627 a8154 gain_cnaBRCA9_(KRAS) 1218 JQ1 BRD2, BRD3, BRD4 4 42 0 NA 2.58782155270541 2.44561618813131 0.142205364574101 0.343656970911557 0.725906943337199 0.20129697882498 0.413800320118339 0.195900267767578 0.702318918504156 NA NA NA 0.513998376399362 99.482402686627 a8155 MACF1_mut 1243 piperlongumine Increases ROS levels 3 44 2.30258509299405 NA 1.52578889399929 1.72282387349751 -0.197034979498222 1.11784795548078 0.844782443294163 0.229440080969566 0.176262772170548 0.233237540697341 0.702411876134578 NA NA NA 0.790947843000816 99.482402686627 a8156 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 295 NVP-BHG712 EPHB4 6 43 2.32630161961136 NA 4.06833078883566 3.86136557279203 0.206965216043633 1.41510404044688 1.21309447644956 0.167426589338955 0.146254416727038 0.170609313669757 0.702576774453311 NA NA NA 0.744465729161689 99.482402686627 a8157 MLL3_mut 1059 AZD8055 MTORC1/2 3 40 0.693147180559945 NA 0.347604708484389 0.114142685536644 0.233462022947744 1.73748480043014 0.962857669754248 0.230133967889896 0.134367807355752 0.242467843671361 0.702633639744745 NA NA NA 0.838560818882175 99.482402686627 a8158 loss_cnaBRCA23 222 BX-912 PDPK1 (PDK1) 3 46 2.32630161961136 NA 4.2104380535688 3.86247704462857 0.347961008940229 0.90466275168259 1.54226966984418 0.228832343653445 0.384630635331291 0.225616191346993 0.70269222927284 NA NA NA 0.586926226566292 99.482402686627 a8159 gain_cnaBRCA14_(RAD21) 298 OSI-930 KIT, VEGFR, PDGFR 21 27 2.32630161961136 NA 3.96857362725575 3.87042903914282 0.0981445881129317 0.828769167705715 0.915926836190624 0.111642804152281 0.11842210344845 0.107153305520689 0.702962207116076 NA NA NA 0.699392366188275 99.482402686627 a8160 gain_cnaBRCA48 312 AV-951 VEGFR 5 43 -2.05572501506252 NA 0.737038042020781 0.620094197997789 0.116943844022992 0.368578851113539 0.665856513087807 0.181177791441247 0.317283109624129 0.175629195966986 0.703156019401625 NA NA NA 0.563609144823896 99.482402686627 a8161 CDH1_mut 1001 AICAR AAPK1 (AMPK) agonist 4 41 7.60090245954208 NA 7.99282270532769 7.71366969476041 0.279153010567281 0.680938053516979 1.42863581577621 0.200889066431827 0.409953606096007 0.195398300591821 0.703234400833605 NA NA NA 0.518271811433655 99.482402686627 a8162 gain_cnaBRCA12_(TERT) 140 Vinorelbine Microtubules 9 38 -2.74887219562247 NA -3.4095129828649 -3.64488914719657 0.235376164331672 1.57715431656613 1.67294921563287 0.142107562368282 0.149241048805006 0.140695343368585 0.703274595860006 NA NA NA 0.697386223748386 99.482402686627 a8163 gain_cnaBRCA63 1248 FK866 NAMPT 6 38 0 NA -0.253262479701951 -0.713460089944661 0.46019761024271 4.02084184994583 2.50712860345371 0.168467058221628 0.114453049241146 0.183555645932467 0.703289557616454 NA NA NA 0.795229534766101 99.482402686627 a8164 loss_cnaBRCA34 299 OSI-027 MTORC1/2 5 43 2.99573227355399 NA 0.94506075505653 1.3066333785809 -0.361572623524368 1.54945322770075 2.03425013767614 0.181078579464422 0.233354977782007 0.177742459900933 0.703310612882235 NA NA NA 0.651474408985862 99.482402686627 a8165 ASH1L_mut 1043 JNK Inhibitor VIII JNK 3 40 2.30258509299405 NA 4.63702287411644 4.80935430420596 -0.172331430089522 0.189933485814884 0.768792588077028 0.229475492619732 0.907325158331915 0.224158547782794 0.70344266797886 NA NA NA 0.319297789797451 99.482402686627 a8166 loss_cnaBRCA33 83 JW-7-52-1 MTOR 4 8 0.182321556793955 NA -1.66097672006577 -2.19938462220742 0.538407902141646 0.713200537367357 2.64230190842279 0.239830031804779 0.754917970377694 0.203764717584081 0.703539561375235 NA NA NA 0.603691586532999 99.482402686627 a8167 CDH1_mut 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 4 44 0.246860077931526 2.32630161961136 -0.569788086267909 -0.237239488190237 -0.332548598077671 0.454627832310024 1.71611653516123 0.199936645800918 0.731474349882954 0.193779729560398 0.703594791909199 NA NA NA 0.350451624295033 99.482402686627 a8168 ASH1L_mut 192 LFM-A13 BTK 3 45 2.77258872223978 NA 4.61537358241285 4.80747656038529 -0.192102977972435 0.22140247284523 0.85940603234941 0.22820973944148 0.867664102860873 0.223529938982708 0.703690644548094 NA NA NA 0.320693951105796 99.482402686627 a8169 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1243 piperlongumine Increases ROS levels 6 41 2.30258509299405 NA 1.83558480267855 1.69190508048334 0.143679722195202 1.0003605616831 0.839401756759335 0.167307341997442 0.143627935465051 0.171169194057807 0.703695178069727 NA NA NA 0.748903636511915 99.482402686627 a8170 gain_cnaBRCA16 286 KIN001-236 TIE2 16 33 2.32630161961136 NA 4.6006632261619 4.51074193751369 0.0899212886482026 0.753483135203487 0.779834788170705 0.116550445403155 0.119340811289583 0.115308126813803 0.703749033327541 NA NA NA 0.701221124591029 99.482402686627 a8171 loss_cnaBRCA24 1264 SGC0946 Q8TEK3 (DOT1L) 3 43 -0.693147180559945 NA 1.82023657852713 1.9598167157486 -0.139580137221468 0.777661538716757 0.601650855513277 0.228537877824978 0.179487000799594 0.231995244322208 0.703774597638378 NA NA NA 0.787434404733383 99.482402686627 a8172 TP53_mut 287 KIN001-244 PDPK1 (PDK1) 38 11 2.99573227355399 NA 3.45023016463048 3.57440452682218 -0.124174362191707 0.956493425229072 0.917319897852528 0.130944981607704 0.129822494244504 0.13536647627769 0.703848881045394 NA NA NA 0.700300825177759 99.482402686627 a8173 CDH1_mut 288 KIN001-055 JAK3, MNK1 4 45 2.32630161961136 NA 4.49665294069531 4.32499401619677 0.171658924498545 0.607642249175829 0.874832381060892 0.1995429006081 0.282499982072302 0.196219216634823 0.70385177832707 NA NA NA 0.629806888764488 99.482402686627 a8174 loss_cnaBRCA60 262 VX-11e ERK 3 46 1.63315443905142 NA 4.06297637572152 3.75814904692182 0.304827328799695 0.0108129557414192 1.36786077482299 0.227747738718159 28.1909346610981 0.222849674769819 0.704032657713145 NA NA NA 0.13783837414025 99.482402686627 a8175 gain_cnaBRCA58_(CCND1) 1268 XAV 939 TNKS1 (tankyrase-1) 9 38 1.6094379124341 NA 3.76970481912362 3.63580165418332 0.133903164940298 0.780186353818488 0.977004808469904 0.141694140879643 0.171629719341964 0.137054765523626 0.704095729703438 NA NA NA 0.666607785966206 99.482402686627 a8176 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 328 SNX-2112 HSP90 6 42 0.940007258491471 NA 0.716667592722346 0.374464580193257 0.34220301252909 1.75307168845195 2.08562907279208 0.166757976521192 0.195201950258675 0.164076640948899 0.704153802357177 NA NA NA 0.675568223004658 99.482402686627 a8177 gain_cnaBRCA48 1239 YK 4-279 RNA helicase A 5 37 2.30258509299405 NA 2.22277265766355 1.98527993724205 0.237492720421502 0.663812208245531 1.35606296573973 0.182197868464581 0.357770944058411 0.175133991873268 0.704197715335402 NA NA NA 0.537563433525922 99.482402686627 a8178 loss_cnaBRCA42 294 MPS-1-IN-1 MPS1 3 46 2.99573227355399 NA 5.00842169070564 4.74008918201388 0.268332508691765 1.08500435793978 1.18326571360264 0.227544828842919 0.247310074589266 0.226772825078134 0.704283533091729 NA NA NA 0.714906470074806 99.482402686627 a8179 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 40 1.38629436111989 NA 2.64189861721422 2.89111583798223 -0.249217220768009 1.18403934811127 1.5254400488045 0.167193935344848 0.210480522598806 0.163373985731738 0.704375396085759 NA NA NA 0.657251869915322 99.482402686627 a8180 gain_cnaBRCA64_(SDHC) 330 XMD13-2 RIPK 8 40 2.32630161961136 NA 3.57022500607448 3.75118049197625 -0.180955485901768 1.56627469555132 1.15166175762042 0.147857594310608 0.115532407192515 0.157125548976863 0.704392375886263 NA NA NA 0.763649085070881 99.482402686627 a8181 gain_cnaBRCA14_(RAD21) 271 VNLG/124 HDAC, RAR 21 28 1.63315443905142 NA 4.09994469059018 4.19006166691106 -0.0901169763208722 0.977981954470508 0.675429710930729 0.11017150071049 0.0921458477929306 0.133421694163694 0.704444536693992 NA NA NA 0.719323830100377 99.482402686627 a8182 gain_cnaBRCA9_(KRAS) 253 XMD14-99 EPHB3, CAMK1 4 44 2.32630161961136 NA 4.79106420098414 4.94601435288105 -0.154950151896907 1.01473738955653 0.758443099618816 0.199232146523559 0.152699756105986 0.204300298828987 0.704588461528702 NA NA NA 0.783485699903694 99.482402686627 a8183 gain_cnaBRCA47_(EGFR) 283 GSK2126458 PI3K, MTOR 7 41 -2.05572501506252 0.0237165266173161 -3.27442259843046 -3.01795661471528 -0.256465983715171 0.652657087125881 1.74461412873167 0.156015607218226 0.392956713064399 0.147004417476329 0.704592832731928 NA NA NA 0.491969412643713 99.482402686627 a8184 loss_cnaBRCA20 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 3 45 2.07944154167984 NA 3.46331732616621 3.19770252579294 0.265614800373272 0.329690674366257 1.19221544217344 0.227403219105833 0.805648509421282 0.222790941114679 0.704686989289625 NA NA NA 0.342792983296464 99.482402686627 a8185 ASH1L_mut 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 3 45 0.246860077931526 2.32630161961136 0.0895770551965208 -0.288587133134037 0.378164188330557 1.31373062417774 1.67745051722997 0.227358963912878 0.287855197535071 0.225439847224247 0.704741675650363 NA NA NA 0.674662022214388 99.482402686627 a8186 loss_cnaBRCA20 345 KIN001-270 CDK9 3 46 2.99573227355399 NA 5.2556487716929 5.09793078490386 0.157717986789041 0.407374458091648 0.704403248415589 0.227142513820805 0.387157279147723 0.223902980492772 0.704781048836336 NA NA NA 0.585043904816721 99.482402686627 a8187 MACF1_mut 1067 CCT007093 PPM1D 3 43 1.88706964903238 NA 3.87454252133348 4.10036369152762 -0.225821170194135 1.10289815359718 0.98622688260518 0.227681807388833 0.204752514506986 0.228974867930607 0.704830308696248 NA NA NA 0.759872835660487 99.482402686627 a8188 gain_cnaBRCA27_(CLTC,PPM1D) 127 GSK269962A ROCK1, ROCK2 3 11 0.916290731874155 NA 2.69286979171852 2.40676710197707 0.286102689741441 1.03404511543727 1.15105570312187 0.252652980233825 0.276682985558571 0.248556771809982 0.704884681322509 NA NA NA 0.702756141018779 99.482402686627 a8189 gain_cnaBRCA63 328 SNX-2112 HSP90 7 41 0.940007258491471 NA 0.69030363335654 0.370619329047685 0.319684304308855 2.31350162101767 2.00997567184169 0.155782948626656 0.138182010077102 0.159048842624018 0.705012039321467 NA NA NA 0.740068351152428 99.482402686627 a8190 gain_cnaBRCA48 1054 PD-0332991 CDK4, CDK6 4 38 1.38629436111989 0.693147180559945 2.61535421854333 2.91106795092334 -0.29571373238001 1.74493485105348 1.45162876843041 0.200395529265245 0.169469784044646 0.203711678089539 0.705051314027353 NA NA NA 0.762357157366552 99.482402686627 a8191 loss_cnaBRCA33 165 DMOG Prolyl-4-Hydroxylase 6 40 8.29404964010203 NA 7.34601977194689 7.60357469877074 -0.257554926823848 1.26273710642225 1.57721146730436 0.166734233527422 0.203965596254304 0.163297650418456 0.705148838597293 NA NA NA 0.665502600630775 99.482402686627 a8192 loss_cnaBRCA42 302 PI-103 PI3Ka, PRKDC (DNAPK) 3 45 2.32630161961136 NA 0.731583720241989 1.15488978868226 -0.423306068440267 1.02840824609775 1.89438356136582 0.226960134228995 0.411612868767322 0.223453199802404 0.705234582542811 NA NA NA 0.565521839935614 99.482402686627 a8193 ARID1A_mut 207 AS601245 JNK 5 43 2.07944154167984 NA 2.05830621058156 2.29037449251898 -0.232068281937413 0.898657514714992 1.32248435799942 0.179735642166742 0.258238848657504 0.175479037263225 0.705404440549603 NA NA NA 0.623582670461114 99.482402686627 a8194 ARID1A_mut 306 TG101348 JAK2 5 43 2.32630161961136 NA 3.43261802860317 3.2007343855006 0.231883643102567 0.847800905827324 1.3253459678458 0.179636027304213 0.273511907699938 0.174960839454975 0.705559846184897 NA NA NA 0.607264965431759 99.482402686627 a8195 gain_cnaBRCA8_(CHD4,WNK1) 306 TG101348 JAK2 4 44 2.32630161961136 NA 2.99000328132679 3.24624217259624 -0.256238891269451 1.05647806074651 1.30563614200194 0.198503467359574 0.24254066486567 0.196255972875076 0.705616784072662 NA NA NA 0.673663800478848 99.482402686627 a8196 loss_cnaBRCA36_(FAT1,IRF2) 260 NG-25 MAP3K7 (TAK1) 9 40 2.32630161961136 NA 3.35628985233432 3.17505545395205 0.181234398382266 1.49937206700886 1.24617517391974 0.140189741833383 0.120873532574083 0.145432521988228 0.70566637210316 NA NA NA 0.742421189919772 99.482402686627 a8197 loss_cnaBRCA33 1230 IOX2 EGLN1 5 42 -2.30258509299405 NA 0.143803941407916 0.262041137416588 -0.118237196008672 0.368116306891192 0.679516779675023 0.179737348397532 0.321195214108297 0.174001878313025 0.705787600611707 NA NA NA 0.561915022055634 99.482402686627 a8198 loss_cnaBRCA36_(FAT1,IRF2) 1009 ATRA Retinoic acid and retinoid X receptor agonist 8 37 2.30258509299405 NA 3.96406579863443 4.13665304952125 -0.172587250886826 1.25698678415777 1.14601661900076 0.148168721650443 0.137302359151266 0.150597511436884 0.705807855960339 NA NA NA 0.728353999109115 99.482402686627 a8199 gain_cnaBRCA31 1230 IOX2 EGLN1 15 32 -2.30258509299405 NA 0.302705398877419 0.224505202980468 0.0782001958969517 0.586851830838068 0.68749153254777 0.118875384937222 0.133253730818691 0.113747140429716 0.705810441932836 NA NA NA 0.6899373603051 99.482402686627 a8200 gain_cnaBRCA19 202 GSK-1904529A IGF1R 4 44 0.0237165266173161 NA 2.03747184660187 2.20351102292999 -0.166039176328122 0.783452766467383 0.841529021267615 0.198169566449431 0.211932593048077 0.197306536235688 0.706088175598585 NA NA NA 0.709203433066213 99.482402686627 a8201 loss_cnaBRCA60 329 QL-XI-92 DDR1 3 45 2.32630161961136 NA 4.05163859450761 4.26678153177166 -0.215142937264045 0.811861825019829 0.958254930791484 0.225905515392305 0.264999450194361 0.224515345917756 0.706538583614818 NA NA NA 0.697222835419574 99.482402686627 a8202 NF1_mut 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 5 42 2.99573227355399 NA 4.0776626775669 3.82028136965351 0.257381307913387 1.43475593335192 1.4365292649519 0.179188509206479 0.179390307389832 0.179168858019753 0.706642946295621 NA NA NA 0.720135253562176 99.482402686627 a8203 gain_cnaBRCA9_(KRAS) 219 AT-7519 CDK9 4 45 2.32630161961136 NA 2.00270163343048 1.64260484736059 0.360096786069886 0.858600807772532 1.87048893573901 0.197555586346671 0.419399542616418 0.192514790753154 0.706659595795431 NA NA NA 0.508176207600138 99.482402686627 a8204 TP53_mut 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 36 10 1.63315443905142 NA 1.8894349476488 2.10637106804806 -0.216936120399253 1.55983546169364 1.75724144323398 0.13539941853645 0.139076284471509 0.123452654292065 0.706671551726854 NA NA NA 0.729213606037623 99.482402686627 a8205 CDH1_mut 1262 UNC1215 LMBL3 5 41 0 NA 2.85308271377998 2.74586635814643 0.107216355633545 0.726944156331226 0.583238304833543 0.179371997067682 0.14748912237585 0.183829413714768 0.706759304938018 NA NA NA 0.764574162205356 99.482402686627 a8206 gain_cnaBRCA19 1192 GSK269962A ROCK1, ROCK2 4 42 1.6094379124341 NA 2.40163963342383 2.69330592427221 -0.291666290848387 1.51768845860688 1.4695386190185 0.198025610325427 0.192177972491215 0.19847473695056 0.706923573575036 NA NA NA 0.73352346617802 99.482402686627 a8207 gain_cnaBRCA48 1059 AZD8055 MTORC1/2 4 39 0.693147180559945 NA 0.313292503560738 0.111675680325025 0.201616823235713 0.756885902824998 1.03212112252889 0.198731817261053 0.266376771562529 0.195342212105604 0.706993058076522 NA NA NA 0.649562799092887 99.482402686627 a8208 gain_cnaBRCA14_(RAD21) 1072 BMS-708163 g-secretase 21 25 1.6094379124341 NA 3.74270226348113 3.63514967347353 0.107552590007606 1.09303858413663 0.835049587897953 0.111924073805403 0.0983977981825407 0.128797848135397 0.707163067764856 NA NA NA 0.713956382805038 99.482402686627 a8209 gain_cnaBRCA8_(CHD4,WNK1) 1042 BIRB 0796 p38, JNK2 3 40 2.30258509299405 NA 4.17083328950196 4.38127772449168 -0.210444434989718 0.777766352946147 0.937203570701318 0.22626962569472 0.270575390916003 0.224545063173671 0.707386480643126 NA NA NA 0.692487882800752 99.482402686627 a8210 gain_cnaBRCA58_(CCND1) 255 CP724714 ERBB2 10 38 2.32630161961136 NA 3.62466732266537 3.84997472799701 -0.22530740533164 1.73248448954042 1.66527971633015 0.134220189287207 0.130048728685247 0.135297033358552 0.707427869651861 NA NA NA 0.717874647994996 99.482402686627 a8211 gain_cnaBRCA15 308 XL-880 MET 22 27 1.63315443905142 NA 1.94411092977285 1.76919594707717 0.174914982695677 1.83545523104931 1.40956210338462 0.10838665341605 0.0952978747379633 0.124091717758071 0.707595059515828 NA NA NA 0.715352579589521 99.482402686627 a8212 loss_cnaBRCA18 1009 ATRA Retinoic acid and retinoid X receptor agonist 14 31 2.30258509299405 NA 4.2035160818293 4.06191819599198 0.141597885837313 1.08417244659032 1.19809329628756 0.121561226644365 0.130604578895759 0.118186026310365 0.707648250920432 NA NA NA 0.697826438513322 99.482402686627 a8213 loss_cnaBRCA18 1058 GDC0941 PI3K (class 1) 12 31 1.38629436111989 0.693147180559945 1.21680372925242 1.39601502385242 -0.179211294599999 1.65538788181696 1.28773655648031 0.128382961989571 0.108259397430949 0.139167668804733 0.707667392825651 NA NA NA 0.739967499699216 99.482402686627 a8214 PTEN_mut 1218 JQ1 BRD2, BRD3, BRD4 8 38 0 NA 2.37232317793924 2.47601528128481 -0.103692103345571 0.53606675506814 0.734296913965492 0.146770673837311 0.193431326164576 0.141212772889911 0.707757817651192 NA NA NA 0.65073707978348 99.482402686627 a8215 loss_cnaBRCA60 258 STF-62247 stimulates autophagy 3 46 2.32630161961136 NA 4.8347216661226 4.61754646446426 0.217175201658345 0.575762404988478 0.980771588464956 0.224586806971585 0.377195870686783 0.221433006637412 0.707944555120354 NA NA NA 0.59374454412691 99.482402686627 a8216 gain_cnaBRCA19 223 ZSTK474 PI3K 4 45 1.63315443905142 2.32630161961136 0.649367102768609 0.935713148760436 -0.286346045991827 1.13852486772764 1.47540089456226 0.196635389008569 0.251506184984206 0.194080162921945 0.707961115087921 NA NA NA 0.663607033526138 99.482402686627 a8217 loss_cnaBRCA22_(SYNCRIP,ZNF292) 330 XMD13-2 RIPK 18 30 2.32630161961136 NA 3.63509391282743 3.77257764322507 -0.137483730397644 1.46814544833264 1.05474573831681 0.112332485889839 0.0936444890755089 0.130347746763163 0.70807361376303 NA NA NA 0.731099723680959 99.482402686627 a8218 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 329 QL-XI-92 DDR1 7 41 2.32630161961136 NA 4.37867668423407 4.23193531520997 0.146741369024099 0.955911237932094 0.951842728411695 0.154079499284626 0.153509408824968 0.15416556185596 0.708084143109603 NA NA NA 0.716781883490415 99.482402686627 a8219 loss_cnaBRCA28_(GPS2) 275 I-BET BRD2, BRD3, BRD4 4 45 2.99573227355399 NA 3.79222164731207 4.06087167373353 -0.268650026421466 1.18616232921782 1.37879703074825 0.196480368976505 0.226486729348941 0.194843780796129 0.70818046092347 NA NA NA 0.692016970107548 99.482402686627 a8220 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1264 SGC0946 Q8TEK3 (DOT1L) 6 40 -0.693147180559945 NA 2.03830132116521 1.9375755146445 0.100725806520717 0.271665780536221 0.641423158074066 0.16491220779116 0.37077104934564 0.157034876668868 0.708217468739311 NA NA NA 0.512594495387352 99.482402686627 a8221 PIK3CA_mut 1007 Docetaxel Microtubules 16 29 -4.38202663467388 NA -4.70469465240239 -4.52249896759599 -0.182195684806399 1.90327745879891 1.32854673434379 0.11729014592277 0.0957273381051736 0.13713908596252 0.708301183473511 NA NA NA 0.736958119849588 99.482402686627 a8222 loss_cnaBRCA17 345 KIN001-270 CDK9 11 38 2.99573227355399 NA 5.03821854248702 5.12766732771839 -0.0894487852313688 0.532620552873436 0.731993582268694 0.128817356865486 0.167940919194352 0.12219886539734 0.708431885196778 NA NA NA 0.65860617187865 99.482402686627 a8223 POLR2B_mut 256 JW-7-24-1 LCK 3 45 2.32630161961136 NA 1.59142146152861 1.85397897311375 -0.262557511585136 0.466002665472475 1.19303381042258 0.224245402459797 0.563424913715745 0.220075499362535 0.708593060335488 NA NA NA 0.460292023018434 99.482402686627 a8224 loss_cnaBRCA29_(MAP2K4) 1262 UNC1215 LMBL3 7 39 0 NA 2.83577333910942 2.74347489433686 0.0922984447725619 0.611178833060464 0.595595709572895 0.154411172064656 0.151017083347569 0.154968283500144 0.708600232357096 NA NA NA 0.721267102756376 99.482402686627 a8225 gain_cnaBRCA30_(CRNKL1,FOXA2) 1114 Cetuximab EGFR 4 41 4.18661983833127 NA 6.44116220785502 6.26711411340411 0.17404809445091 0.724972252605668 0.894151671023242 0.197020610344439 0.240075525408529 0.194651645902238 0.708676515683203 NA NA NA 0.677589539168917 99.482402686627 a8226 TP53_mut 326 GSK690693 AKT 37 11 2.32630161961136 NA 2.88215265131555 3.13273708416133 -0.250584432845785 2.01394724515674 1.65422060631123 0.129072485759429 0.124424526733958 0.151481871214606 0.708758961924029 NA NA NA 0.680054039533872 99.482402686627 a8227 loss_cnaBRCA36_(FAT1,IRF2) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 9 39 2.32630161961136 NA 4.87944962797277 4.97673058243974 -0.0972809544669699 0.325446763510824 0.755622276272556 0.138960475792128 0.298915108011927 0.128742835569713 0.708813930659537 NA NA NA 0.553859037899507 99.482402686627 a8228 loss_cnaBRCA34 341 EX-527 SIRT1 5 44 2.99573227355399 NA 5.53692186648423 5.65366589473628 -0.116744028252053 0.316866139287417 0.681556616050378 0.177306498084225 0.368433271269035 0.171290286826918 0.708832419860929 NA NA NA 0.521383641052639 99.482402686627 a8229 gain_cnaBRCA62 197 Bryostatin 1 PRKC 9 39 -4.8283137373023 NA -2.69705919373735 -2.83212962986438 0.135070436127033 1.30424544556079 0.886669523185667 0.138924065203804 0.103562129802152 0.152334587571867 0.708886636286699 NA NA NA 0.77391578670103 99.482402686627 a8230 gain_cnaBRCA48 151 QS11 ARFGAP 5 43 2.32630161961136 NA 3.99720027988027 3.73292077797365 0.264279501906624 1.68199741554853 1.47013273912989 0.177398280305662 0.157122418538579 0.17976574146838 0.709054208904559 NA NA NA 0.750738928883102 99.482402686627 a8231 gain_cnaBRCA48 1011 ABT-263 BCL2, BCL2L1, BCL2L2 4 39 0.693147180559945 NA 1.9828578751472 1.65108437000816 0.331773505139033 0.555928139649302 1.7406253681275 0.197194506739854 0.596792069831772 0.190605923143556 0.709152345241308 NA NA NA 0.416994666608184 99.482402686627 a8232 BRCA1_mut 136 Mitomycin C DNA crosslinker 4 44 2.77258872223978 NA 0.132796595452851 -0.158587274914094 0.291383870366945 0.57041002164655 1.53117440154535 0.195881385828468 0.510832312387909 0.19030090241377 0.709321688082762 NA NA NA 0.450081493923554 99.482402686627 a8233 gain_cnaBRCA64_(SDHC) 1230 IOX2 EGLN1 9 38 -2.30258509299405 NA 0.323327999981534 0.231968302071117 0.0913596979104173 0.52211591814462 0.683678298868712 0.138873564310963 0.174979721428665 0.133629658951572 0.709707405275399 NA NA NA 0.66419439628697 99.482402686627 a8234 loss_cnaBRCA24 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 3 45 2.77258872223978 NA -0.140024055161599 -0.456294077963572 0.316270022801973 0.87933220769355 1.43603684603214 0.223293106565572 0.35967069104808 0.22023809742476 0.709772566742647 NA NA NA 0.609215912732435 99.482402686627 a8235 gain_cnaBRCA12_(TERT) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 9 34 0.693147180559945 NA 1.86878542398445 1.63248979750139 0.236295626483064 1.20200089761584 1.77953200936113 0.140444605383505 0.196585232965928 0.132785263338925 0.709848002326425 NA NA NA 0.644448240668065 99.482402686627 a8236 gain_cnaBRCA47_(EGFR) 1175 AG-014699 PARP1, PARP2 7 36 1.6094379124341 NA 3.99546491182981 3.83553565291581 0.159929258914 0.820674504193964 1.06563547818724 0.154757145216887 0.194875383719976 0.150078767259191 0.709857423082915 NA NA NA 0.663745590851994 99.482402686627 a8237 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 83 JW-7-52-1 MTOR 3 9 0.182321556793955 NA -2.44952239842361 -1.87671296251684 -0.572809435906767 2.11591036957012 2.2770293096915 0.25506597737609 0.270715359282039 0.251559974862323 0.710023295506311 NA NA NA 0.712302667710877 99.482402686627 a8238 gain_cnaBRCA27_(CLTC,PPM1D) 83 JW-7-52-1 MTOR 3 9 0.182321556793955 NA -2.44952239842361 -1.87671296251684 -0.572809435906767 2.11591036957012 2.2770293096915 0.25506597737609 0.270715359282039 0.251559974862323 0.710023295506311 NA NA NA 0.712302667710877 99.482402686627 a8239 gain_cnaBRCA13_(FGFR1,WHSC1L1) 279 BIX02189 MAP2K5 (MEK5) 11 38 2.99573227355399 NA 4.93753810316709 5.05335597494418 -0.115817871777087 1.18960030250408 0.811602924059725 0.127927057896316 0.0973586435152155 0.142702629997627 0.710352881769799 NA NA NA 0.766659367825867 99.482402686627 a8240 loss_cnaBRCA33 1192 GSK269962A ROCK1, ROCK2 5 41 1.6094379124341 NA 2.43551362530417 2.69628876162457 -0.260775136320397 1.1401909341331 1.50215607490596 0.177045116025009 0.228711813533816 0.17360056033906 0.710384766421009 NA NA NA 0.659013638511454 99.482402686627 a8241 POLR2B_mut 166 FTI-277 Farnesyl transferase (FNTA) 3 44 0.0237165266173161 NA 2.41555302831012 2.2327175675709 0.182835460739221 0.408239836095552 0.834323041768391 0.222942807049776 0.447862860439781 0.219142288521353 0.710440669649699 NA NA NA 0.538875214941473 99.482402686627 a8242 loss_cnaBRCA57 254 AC220 FLT3 5 43 0.0237165266173161 NA 2.36419573551485 2.20743238111854 0.156763354396315 1.02760929304534 0.874224652801002 0.176413310138229 0.152551514916476 0.179317014103924 0.71059430481576 NA NA NA 0.757297296059971 99.482402686627 a8243 NF1_mut 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 41 2.30258509299405 NA 3.41050089841992 3.15407342502819 0.256427473391731 1.75669607202034 1.27100163997298 0.195635574257458 0.14597145031287 0.201752275785563 0.710628740792658 NA NA NA 0.79271086207786 99.482402686627 a8244 loss_cnaBRCA33 167 OSU-03012 PDPK1 (PDK1) 6 42 2.77258872223978 NA 2.07819725837856 2.27223356604227 -0.194036307663707 0.561387395840249 1.24646670896749 0.1628857379717 0.34563709321134 0.15566906542128 0.710700556349858 NA NA NA 0.527371103404228 99.482402686627 a8245 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1091 BMS-536924 IGF1R 18 29 1.38629436111989 NA 2.9472070566837 3.07053369937358 -0.123326642689875 1.21193887196435 1.02826094287407 0.111987168311783 0.101759788008106 0.119937106961553 0.710743691559599 NA NA NA 0.722025871105331 99.482402686627 a8246 PTEN_mut 273 CUDC-101 HDAC, EGFR 9 40 1.63315443905142 NA 0.150665246270649 -0.0665441067469113 0.217209353017561 1.57999579895235 1.57754487315891 0.137651799505359 0.137474639591818 0.137688224730252 0.710745248708297 NA NA NA 0.715917143686547 99.482402686627 a8247 loss_cnaBRCA38 224 AS605240 PI3Kgamma 4 45 2.99573227355399 2.32630161961136 2.98605835513894 3.29551882880696 -0.309460473668025 0.937063604126156 1.62506448552423 0.194620804825132 0.330244897257116 0.190429657668752 0.71081359720683 NA NA NA 0.583930059254663 99.482402686627 a8248 loss_cnaBRCA7_(FAS,PTEN) 1067 CCT007093 PPM1D 4 42 1.88706964903238 NA 4.26233318294798 4.06880794209276 0.193525240855215 0.478867330602673 1.01935033584777 0.195105744201527 0.404131224846046 0.189851549609061 0.71104286306742 NA NA NA 0.524239364877577 99.482402686627 a8249 NF1_mut 231 FMK RSK 5 44 2.99573227355399 2.32630161961136 5.68350921494844 5.57851611582421 0.104993099124225 0.245859430212945 0.619559242185864 0.175887412951747 0.427045238953363 0.169464180299852 0.711054429039485 NA NA NA 0.481556057759721 99.482402686627 a8250 TP53_mut 64 CMK RSK 9 3 1.38629436111989 NA 2.28274892974169 1.96837911450699 0.314369815234701 1.20784088995666 1.34813852040238 0.254103180380781 0.260274194928092 0.233188066713553 0.711061170034148 NA NA NA 0.742448347894901 99.482402686627 a8251 gain_cnaBRCA27_(CLTC,PPM1D) 172 Embelin XIAP 9 39 3.46573590279973 NA 2.88406326002621 3.01821577666669 -0.134152516640484 1.21985405003336 0.913435007553276 0.137779269102516 0.109974235554503 0.146865968055926 0.711173989395517 NA NA NA 0.762490034018679 99.482402686627 a8252 gain_cnaBRCA10_(MDM2,NUP107) 1061 SB590885 BRAF 3 39 1.6094379124341 NA 4.23917973795175 3.9944295393735 0.244750198578248 1.06472827032068 1.09709277023081 0.223414707496147 0.229871043533514 0.223089792604099 0.711199501916274 NA NA NA 0.733894415400342 99.482402686627 a8253 loss_cnaBRCA20 211 TL-2-105 CRAF 3 46 2.32630161961136 1.63315443905142 3.67945029013588 3.92243004824036 -0.242979758104477 0.430891192843069 1.11514663478808 0.221944618145323 0.563900497713283 0.217890410574257 0.711220588646613 NA NA NA 0.459918997885644 99.482402686627 a8254 PTEN_mut 265 Tubastatin A HDAC6 9 40 2.99573227355399 NA 4.80855301277371 4.66548095143903 0.143072061334682 1.04554406636608 1.04029524089965 0.137411989136811 0.136839819513249 0.13753024690467 0.711225842690363 NA NA NA 0.717009617797834 99.482402686627 a8255 POLR2B_mut 1036 PLX4720 BRAF 3 40 2.30258509299405 NA 4.34539550810592 4.61545719209206 -0.270061683986145 0.294028621666704 1.23933758535703 0.223103863891575 0.918487739238779 0.217908088302143 0.711288962859929 NA NA NA 0.322164118554019 99.482402686627 a8256 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 269 NSC-207895 MDM4 7 42 2.99573227355399 NA 4.44826479256958 4.62988866731589 -0.181623874746306 1.44530020176637 1.15382490648523 0.151986540543964 0.125665155601815 0.157410256725664 0.711350801215379 NA NA NA 0.760728423757249 99.482402686627 a8257 gain_cnaBRCA31 1046 681640 WEE1, CHEK1 11 25 0.693147180559945 NA 2.53300511102133 2.67814238353598 -0.145137272514653 0.970731941888369 1.11578983740124 0.134991418619017 0.149513234551978 0.130075815041199 0.71139265017162 NA NA NA 0.697144089775798 99.482402686627 a8258 loss_cnaBRCA38 1042 BIRB 0796 p38, JNK2 3 40 2.30258509299405 NA 4.55952818200467 4.35212560755397 0.207402574450701 0.927237169742622 0.930253912306329 0.222987869843164 0.223678020272064 0.222952649493835 0.711432100336948 NA NA NA 0.740236840245212 99.482402686627 a8259 loss_cnaBRCA42 281 CH5424802 ALK 3 45 1.63315443905142 NA 3.79813470942077 3.56037995382242 0.237754755598353 0.49575919427745 1.09041543142241 0.221900892609545 0.479577097798199 0.218040527258689 0.711498245095399 NA NA NA 0.515616759420469 99.482402686627 a8260 gain_cnaBRCA9_(KRAS) 1003 Camptothecin TOP1 4 41 -2.30258509299405 NA -2.24524385131555 -2.55699242868441 0.311748577368862 0.504351748715214 1.65188636709028 0.194991486156895 0.618117371780727 0.188722773902416 0.711537261621664 NA NA NA 0.405005360591421 99.482402686627 a8261 gain_cnaBRCA27_(CLTC,PPM1D) 1149 TW 37 BCL2, BCL2L1 9 34 1.6094379124341 NA -0.280890704659031 -0.105720766979683 -0.175169937679347 1.02575574635095 1.30515119283361 0.139519077692069 0.170771587975502 0.134214287694161 0.711671236509849 NA NA NA 0.674036108102001 99.482402686627 a8262 gain_cnaBRCA31 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 15 32 2.99573227355399 NA 3.96147280861065 3.79431371200381 0.167159096606837 1.42920414141201 1.43971600348181 0.116369274225063 0.116959566351164 0.116105604301529 0.711723119915521 NA NA NA 0.71206891769136 99.482402686627 a8263 CDH1_mut 1059 AZD8055 MTORC1/2 4 39 0.693147180559945 NA 0.310182058880545 0.111994700292225 0.19818735858832 1.52435302161724 0.962904858405815 0.195339913375357 0.130014081894269 0.205822368490734 0.711760510793609 NA NA NA 0.81411416169163 99.482402686627 a8264 loss_cnaBRCA17 110 Roscovitine CDKs 3 10 2.77258872223978 NA 3.87850808218376 4.14047873188394 -0.26197064970018 0.741564854179834 1.10634805427608 0.249615356890728 0.353267348396544 0.236788638699777 0.711762352426527 NA NA NA 0.655373385078432 99.482402686627 a8265 loss_cnaBRCA33 6 PHA-665752 MET 5 9 0.693147180559945 NA 2.96992639188834 2.80576318144233 0.164163210446011 0.367592641425796 0.917225307138068 0.21089773264785 0.446590034580846 0.178978064787848 0.711955096865108 NA NA NA 0.645211398756364 99.482402686627 a8266 gain_cnaBRCA10_(MDM2,NUP107) 263 FR-180204 ERK 5 44 2.99573227355399 NA 5.47395550701733 5.34469504645522 0.129260460562108 0.463795178418285 0.757956235379005 0.175267635134173 0.278701604882859 0.170538158443242 0.712025676634559 NA NA NA 0.602763571780804 99.482402686627 a8267 loss_cnaBRCA28_(GPS2) 300 CX-5461 RNA Pol I 4 45 2.32630161961136 NA 4.21806329432813 3.88519213757 0.332871156758134 1.42537427827382 1.73633147213342 0.193736385118585 0.233532456584843 0.19170945300504 0.712067185849649 NA NA NA 0.68422704559969 99.482402686627 a8268 loss_cnaBRCA20 254 AC220 FLT3 3 45 0.0237165266173161 NA 2.40824115830401 2.21146327979465 0.19677787850936 0.246545562332194 0.90707836840282 0.221440003817143 0.79814001374814 0.216935917958055 0.712069863471555 NA NA NA 0.349682371348934 99.482402686627 a8269 gain_cnaBRCA16 1203 QL-XII-61 BTK 9 14 2.30258509299405 NA 4.37403614382001 4.12953775580163 0.244498388018384 1.70647959053769 1.41036086964682 0.159809025379781 0.14327647946926 0.173358743340356 0.71212161884968 NA NA NA 0.72517290000724 99.482402686627 a8270 loss_cnaBRCA33 1026 17-AAG HSP90 5 38 0 NA -0.615305114910024 -0.933167378556881 0.317862263646857 1.85120720208736 1.79281335126156 0.176728213255324 0.171705394884184 0.177298023479792 0.712184703127044 NA NA NA 0.7318647256341 99.482402686627 a8271 NF1_mut 171 AKT inhibitor VIII AKT1, AKT2, AKT3 4 43 0.940007258491471 NA 2.1125073818368 1.86783556875175 0.24467181308505 0.965963469496464 1.27959643528803 0.194012056105669 0.253293028992693 0.191210139648425 0.712270953746473 NA NA NA 0.662736186831839 99.482402686627 a8272 gain_cnaBRCA48 265 Tubastatin A HDAC6 5 44 2.99573227355399 NA 4.85545397060188 4.6731578481708 0.18229612243108 0.838866559007671 1.05805931107735 0.175082272211716 0.217312420519808 0.172292914511058 0.712316250802502 NA NA NA 0.671631700714226 99.482402686627 a8273 gain_cnaBRCA8_(CHD4,WNK1) 203 BMS-345541 IKBKB 4 45 2.77258872223978 NA 3.7125936526268 3.51630890035391 0.196284752272891 0.808814171456654 1.02671199045861 0.193535903959094 0.242682137875239 0.191178007169483 0.712351462456749 NA NA NA 0.673891188891994 99.482402686627 a8274 POLR2B_mut 1371 PLX4720 (rescreen) BRAF 3 44 2.30258509299405 NA 4.50771503007299 4.72074500153085 -0.213029971457857 0.567341948491225 0.976841646803756 0.221364582654876 0.375487784790784 0.218080353304852 0.712395975253643 NA NA NA 0.596344144591609 99.482402686627 a8275 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1010 Gefitinib EGFR 6 39 -0.693147180559945 NA 1.25205124081655 1.42264344142672 -0.170592200610165 1.17854392589746 1.03011357267179 0.162708467256975 0.144748275275577 0.165605235321483 0.712435197805297 NA NA NA 0.748327959971468 99.482402686627 a8276 gain_cnaBRCA63 1046 681640 WEE1, CHEK1 5 31 0.693147180559945 NA 2.799590422739 2.60705366761094 0.19253675512806 1.59667125458756 0.985000150982249 0.179074460820742 0.120586347737434 0.195468756970302 0.712513846910798 NA NA NA 0.8050740086143 99.482402686627 a8277 TP53_mut 283 GSK2126458 PI3K, MTOR 37 11 -2.05572501506252 0.0237165266173161 -3.10331790929718 -2.89403788621309 -0.209280023084093 1.65356265424438 1.60907155159672 0.127299818174141 0.126563104546968 0.130062595958781 0.712574167591943 NA NA NA 0.711388236118942 99.482402686627 a8278 BRCA1_mut 294 MPS-1-IN-1 MPS1 4 45 2.99573227355399 NA 4.96574335583255 4.73791986714278 0.227823488689772 1.15929750618774 1.18071599530152 0.193175447718076 0.19651857049098 0.192953673530604 0.712862682963145 NA NA NA 0.728083816953458 99.482402686627 a8279 BRCA1_mut 1006 Cytarabine DNA synthesis 4 41 0.693147180559945 NA 0.936629692777612 1.23506045352728 -0.298430760749667 1.07861182544663 1.5674250026473 0.193991518949853 0.276680408752327 0.190395559752864 0.712948609206327 NA NA NA 0.638804308632204 99.482402686627 a8280 loss_cnaBRCA17 1050 ZM-447439 AURKB 6 33 1.38629436111989 0.693147180559945 3.07264856796388 2.85433781130366 0.218310756660228 1.29569825287984 1.33181872578256 0.164515126769818 0.168488887111646 0.16391927252108 0.712985317871367 NA NA NA 0.716532487972689 99.482402686627 a8281 gain_cnaBRCA16 293 MP470 PDGFR 16 32 2.99573227355399 NA 3.65849580085401 3.46812986278008 0.190365938073927 2.01928495287299 1.48795607945723 0.113327598184563 0.0942739348416771 0.127937874445439 0.712987091442265 NA NA NA 0.741038050455195 99.482402686627 a8282 loss_cnaBRCA18 37 Crizotinib MET, ALK 6 8 0.693147180559945 NA 2.74525974457061 2.58256703553122 0.162692709039387 0.730208729785166 0.846704870381545 0.203307815427069 0.222803018374285 0.192148072758899 0.71315194986676 NA NA NA 0.707083539641814 99.482402686627 a8283 CDH1_mut 1043 JNK Inhibitor VIII JNK 4 39 2.30258509299405 NA 4.66497797479474 4.81090586901048 -0.14592789421574 0.926574404279253 0.735433834630044 0.19429308348589 0.157491825310296 0.198424232533642 0.713234244479444 NA NA NA 0.777914077287043 99.482402686627 a8284 loss_cnaBRCA60 235 QL-XII-47 BTK, BMX 3 46 2.32630161961136 NA 1.3952255351694 1.72847832697179 -0.333252791802389 0.754280916749755 1.53820713909269 0.220238537853317 0.441815223482514 0.216650139849798 0.713338880245287 NA NA NA 0.542892161372835 99.482402686627 a8285 gain_cnaBRCA14_(RAD21) 172 Embelin XIAP 21 27 3.46573590279973 NA 3.05196710037921 2.94724724156569 0.104719858813525 1.09881623533043 0.865231979603311 0.107548368315451 0.0953024313315085 0.121030961964139 0.713349710543973 NA NA NA 0.721830023969625 99.482402686627 a8286 PIK3CA_mut 1072 BMS-708163 g-secretase 16 30 1.6094379124341 NA 3.75598265716303 3.64599222851111 0.109990428651922 1.02861141627332 0.924106557292355 0.114452854856686 0.106930981818595 0.119023534444118 0.713367610940884 NA NA NA 0.723306853223067 99.482402686627 a8287 MACF1_mut 1061 SB590885 BRAF 3 39 1.6094379124341 NA 4.23728175003604 3.99457553844394 0.242706211592098 0.815383751586351 1.10831360254631 0.221542495451449 0.297658876718976 0.218986946505474 0.713508440296522 NA NA NA 0.667077958131849 99.482402686627 a8288 gain_cnaBRCA47_(EGFR) 1161 ZG-10 IRAK1 3 23 2.30258509299405 NA 2.2614998609594 1.93809460586812 0.32340525509128 2.44300715129407 1.28521306541114 0.22802843577074 0.132379987066338 0.251635517716919 0.713544847220211 NA NA NA 0.84142284240334 99.482402686627 a8289 loss_cnaBRCA20 156 AZD6482 PI3Kbeta 3 44 1.63315443905142 NA 1.74997823770884 2.07399149950982 -0.324013261800982 1.96521155634881 1.44383646665271 0.22027660836624 0.164874494429988 0.224411330011737 0.71374503629904 NA NA NA 0.803835676987317 99.482402686627 a8290 PTEN_mut 1011 ABT-263 BCL2, BCL2L1, BCL2L2 6 37 0.693147180559945 NA 1.44672947781717 1.72009040713525 -0.273360929318079 1.86582569344659 1.65551012208986 0.162466647668068 0.146509360589371 0.165121871301516 0.713913307881758 NA NA NA 0.746306654987035 99.482402686627 a8291 loss_cnaBRCA38 1069 EHT 1864 Rac GTPases 3 43 2.30258509299405 NA 3.3834289025931 3.57383979437452 -0.190410891781413 0.915441352921863 0.861723752024885 0.220322311864653 0.207999006352147 0.220965119429497 0.71393015704507 NA NA NA 0.756624463553172 99.482402686627 a8292 PIK3CA_mut 226 GSK1070916 AURKB 17 32 0.940007258491471 2.32630161961136 2.54557854905447 2.32870632554147 0.216872223513001 1.77003602955718 2.05042693967841 0.110678211206604 0.12252418588748 0.105769300683796 0.713950180938252 NA NA NA 0.701700025567994 99.482402686627 a8293 BRCA2_mut 164 JQ12 HDAC 6 41 1.63315443905142 NA 1.34573298652691 1.61185636908037 -0.266123382553459 1.709184404213 1.64434405714731 0.161123407409854 0.155701972178945 0.16184166652759 0.714140615272252 NA NA NA 0.731859106899916 99.482402686627 a8294 loss_cnaBRCA24 1239 YK 4-279 RNA helicase A 3 39 2.30258509299405 NA 1.74602166182332 2.03413220463599 -0.28811054281267 1.07851086157079 1.31443467961552 0.221002494405143 0.267137358628965 0.219189699785572 0.71417491361089 NA NA NA 0.696429929054149 99.482402686627 a8295 gain_cnaBRCA48 1028 VX-702 p38 5 40 0.693147180559945 NA 3.53380758853135 3.41345941221403 0.120348176317321 0.516422262006976 0.703495877043217 0.174863141385672 0.233042192738963 0.171071615690404 0.714202050699259 NA NA NA 0.655200011913885 99.482402686627 a8296 ASH1L_mut 304 SB52334 ALK5 3 46 2.99573227355399 NA 4.03799043624856 4.31910270292324 -0.281112266674676 1.25463176429812 1.28214152102422 0.219450439576678 0.224059580407595 0.21925213563797 0.714318165469509 NA NA NA 0.739374141157351 99.482402686627 a8297 loss_cnaBRCA34 196 Phenformin AAPK1 (AMPK) agonist 4 44 8.29404964010203 NA 7.52337783092354 7.17279810706198 0.350579723861559 0.428451098651184 1.8817412779119 0.192347962312098 0.818249095323192 0.18630601771705 0.714325522292408 NA NA NA 0.336603155002047 99.482402686627 a8298 gain_cnaBRCA61_(NOTCH2) 158 PF-562271 FAK 3 42 0.940007258491471 NA 2.06674023159639 2.35228663226497 -0.285546400668573 1.48461018152838 1.28747200897685 0.220107263511806 0.192337627898124 0.221788433983505 0.714449225806508 NA NA NA 0.773593376985085 99.482402686627 a8299 gain_cnaBRCA16 1047 Nutlin-3a MDM2 14 29 2.07944154167984 1.38629436111989 4.28877488830385 4.16744027552637 0.121334612777481 0.944772605180808 1.04177704260156 0.119892696023335 0.128427319031187 0.116468887118572 0.714469206728503 NA NA NA 0.705727292218243 99.482402686627 a8300 loss_cnaBRCA29_(MAP2K4) 1013 Nilotinib ABL 6 34 0.693147180559945 NA 3.06912515401526 3.22651601094503 -0.157390856929769 1.30665778357289 0.901705952395897 0.163141632741008 0.120453005299829 0.174547873962205 0.714600465923802 NA NA NA 0.786613890495684 99.482402686627 a8301 NF1_mut 1494 SN-38 TOP1 5 43 -2.99573227355399 NA -3.56755209951199 -3.27311832508773 -0.294433774424257 1.29390378769628 1.72705930796588 0.173830648636885 0.227554612038412 0.170482723474644 0.714638330910411 NA NA NA 0.660133975874029 99.482402686627 a8302 gain_cnaBRCA12_(TERT) 1164 XMD8-92 MAP2K5 (ERK5) 5 21 2.30258509299405 NA 3.68858968262874 3.93113167820325 -0.242541995574502 1.40505418641412 1.29918778425111 0.184103341903823 0.172621097406571 0.186687404634357 0.71464768654546 NA NA NA 0.737499575913106 99.482402686627 a8303 TP53_mut 1031 Elesclomol HSP70 34 10 -1.6094379124341 NA -3.03165872529693 -2.79370824450172 -0.237950480795211 1.7454754588496 1.97531873529448 0.132400385729704 0.13632416290289 0.120461815373678 0.714687232971369 NA NA NA 0.736527927523541 99.482402686627 a8304 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 34 Imatinib ABL, KIT, PDGFR 4 10 0.693147180559945 NA 2.70072163234366 2.80807300473067 -0.107351372387005 0.728666777967433 0.36927304867427 0.221443904557341 0.147325740150326 0.29071001193401 0.714705247961944 NA NA NA 0.794257817665751 99.482402686627 a8305 loss_cnaBRCA60 303 PIK-93 PI4K, PI3K 3 46 2.99573227355399 NA 3.08559590404778 2.77234880590366 0.313247098144119 0.48939124514743 1.45823144385437 0.218987324291571 0.640074993678632 0.214813018512445 0.714893855913356 NA NA NA 0.418700699203412 99.482402686627 a8306 CDH1_mut 1008 Methotrexate Dihydrofolate reductase (DHFR) 4 41 -1.6094379124341 NA 0.490248800697479 0.701420930424241 -0.211172129726762 1.21417657077366 1.0873988927979 0.192548895100915 0.173922092395677 0.194199323840961 0.714986512377136 NA NA NA 0.756802655495384 99.482402686627 a8307 gain_cnaBRCA27_(CLTC,PPM1D) 1192 GSK269962A ROCK1, ROCK2 10 36 1.6094379124341 NA 2.51652840255687 2.71000342576554 -0.193475023208671 1.39734054022827 1.49184564800161 0.131346856178267 0.138459464703618 0.129688365192364 0.715048862883662 NA NA NA 0.708046880607534 99.482402686627 a8308 gain_cnaBRCA64_(SDHC) 133 Doxorubicin DNA intercalating 8 40 0.0237165266173161 NA -0.811839991791905 -1.07440598188235 0.262565990090446 2.05014110509847 1.8073408599491 0.142208168844498 0.128072155344563 0.145277515663449 0.715168684328558 NA NA NA 0.743595466053238 99.482402686627 a8309 gain_cnaBRCA58_(CCND1) 1043 JNK Inhibitor VIII JNK 8 35 2.30258509299405 NA 4.88535952505802 4.77721041686068 0.10814910819734 0.497576596370023 0.793288554677964 0.143989787585322 0.217351678085991 0.13633010026376 0.715187026338952 NA NA NA 0.631383159010155 99.482402686627 a8310 TP53_mut 274 PXD101, Belinostat HDAC 37 11 2.99573227355399 NA 0.628032949788557 0.817721951289548 -0.189689001500991 1.41285447829027 1.79754450263458 0.126049975918982 0.134259404925083 0.105526734510869 0.71526860739712 NA NA NA 0.752476983152194 99.482402686627 a8311 loss_cnaBRCA36_(FAT1,IRF2) 299 OSI-027 MTORC1/2 9 39 2.99573227355399 NA 1.48910292627005 1.21816955686746 0.270933369402592 2.06357378736677 1.98274549610495 0.135667635304331 0.131293279194207 0.136645560378189 0.715400167359227 NA NA NA 0.727014983164471 99.482402686627 a8312 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 177 GSK-650394 SGK3 15 32 2.77258872223978 NA 3.88104138868254 4.07696885305435 -0.195927464371803 1.96586174846396 1.5754786644103 0.114810578848311 0.0996649253310377 0.124360595162448 0.715409643563181 NA NA NA 0.738157996072031 99.482402686627 a8313 loss_cnaBRCA33 106 XMD8-85 MAP2K5 (ERK5) 4 9 2.07944154167984 NA 3.02929629620447 3.31061499657425 -0.281318700369783 1.02946249435595 1.32541691715527 0.224756230640209 0.273267556527916 0.212249215117591 0.715500800352584 NA NA NA 0.689927406859383 99.482402686627 a8314 gain_cnaBRCA19 1049 PD-173074 FGFR1, FGFR3 3 40 0.693147180559945 NA 3.17285618094013 2.92013207557115 0.252724105368987 0.649979714040917 1.17049820850982 0.219648673280219 0.388818450652566 0.215911569562104 0.715557196770817 NA NA NA 0.587418161140624 99.482402686627 a8315 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 18 28 0 NA 0.792983917126665 0.563363792182365 0.2296201249443 2.00157750504399 2.11640728272006 0.110777994324275 0.114719577116377 0.108495244190044 0.715613591061952 NA NA NA 0.712517106843828 99.482402686627 a8316 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 8 35 1.6094379124341 NA 2.37845318276741 2.61051584680793 -0.232062664040515 1.02490038073569 1.71071942379492 0.1437466424268 0.226424605164003 0.135652089298037 0.715646299696687 NA NA NA 0.622976088591946 99.482402686627 a8317 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1239 YK 4-279 RNA helicase A 7 35 2.30258509299405 NA 1.84853091242053 2.04655727369513 -0.198026361274599 1.05500765024526 1.34278763294738 0.151898363614074 0.1877013510078 0.147474072903053 0.715650151178804 NA NA NA 0.674909742346048 99.482402686627 a8318 gain_cnaBRCA63 1218 JQ1 BRD2, BRD3, BRD4 6 40 0 NA 2.55656979503523 2.44319368355313 0.113376111482103 1.21329987346238 0.61195744020877 0.160463290890022 0.0934444270224495 0.185267968052524 0.715730802241864 NA NA NA 0.830528991239252 99.482402686627 a8319 gain_cnaBRCA13_(FGFR1,WHSC1L1) 302 PI-103 PI3Ka, PRKDC (DNAPK) 11 37 2.32630161961136 NA 0.947547253531045 1.18221005034016 -0.234662796809116 1.63844174316951 1.92360844512863 0.125802438564384 0.143223155652254 0.121990937086692 0.715802690659579 NA NA NA 0.693572197593692 99.482402686627 a8320 loss_cnaBRCA22_(SYNCRIP,ZNF292) 154 CHIR-99021 GSK3B 17 30 0.940007258491471 NA 3.34014790880361 3.23876726451275 0.101380644290857 1.15788399480869 0.741598414326827 0.111205001629282 0.0875568232615632 0.136705583955278 0.71584312125228 NA NA NA 0.747907138237304 99.482402686627 a8321 loss_cnaBRCA7_(FAS,PTEN) 229 LY317615 PRKCB (PKCbeta) 4 45 2.99573227355399 2.32630161961136 3.07377034435221 3.38389975890817 -0.31012941455596 0.333663458683545 1.67572867998278 0.191018595072326 0.929467721097066 0.185071377163007 0.715924435016415 NA NA NA 0.312390680905548 99.482402686627 a8322 gain_cnaBRCA47_(EGFR) 223 ZSTK474 PI3K 7 42 1.63315443905142 2.32630161961136 0.725827742349591 0.943422997829688 -0.217595255480097 0.733910002080714 1.53379517309254 0.14941101782726 0.296487654975666 0.141867218842113 0.716021652853779 NA NA NA 0.55871516051738 99.482402686627 a8323 PIK3CA_mut 153 Midostaurin KIT 16 31 -0.669430653942629 NA 0.721044118216863 0.555998230399359 0.165045887817504 1.65337423524622 1.36051811041331 0.112685648064747 0.0998236722812639 0.121311055365051 0.716030534786533 NA NA NA 0.733845268294172 99.482402686627 a8324 loss_cnaBRCA38 238 CAL-101 PI3Kdelta 4 45 2.99573227355399 2.32630161961136 4.55219129622812 4.73378847927237 -0.181597183044253 0.683023366845451 0.966709655845217 0.190927138122206 0.265872577512188 0.187850800854449 0.716054367080607 NA NA NA 0.648944375858927 99.482402686627 a8325 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1067 CCT007093 PPM1D 6 40 1.88706964903238 NA 4.2238764192593 4.0649001946033 0.158976224656001 1.10521653562767 0.976485365112183 0.160265462542581 0.143841699369541 0.162804513345407 0.716065563749054 NA NA NA 0.749798445324107 99.482402686627 a8326 TP53_mut 288 KIN001-055 JAK3, MNK1 38 11 2.32630161961136 NA 4.36319545139435 4.25544684896823 0.10774860242612 0.870838038516725 0.820500453825344 0.125234523492644 0.123729784024645 0.131320588457658 0.716174083005248 NA NA NA 0.709923385397524 99.482402686627 a8327 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1046 681640 WEE1, CHEK1 5 31 0.693147180559945 NA 2.79729125305133 2.60742450143153 0.189866751619793 1.07406382985406 1.07539355453882 0.176581270924171 0.176774178910384 0.176555597546999 0.716334543600266 NA NA NA 0.727800528772206 99.482402686627 a8328 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 9 37 1.63315443905142 NA 1.76148053263755 1.97919037843512 -0.217709845797573 1.34752642229481 1.65368006724479 0.135867185931293 0.161562580291982 0.131651732466185 0.7164455758299 NA NA NA 0.68446458809957 99.482402686627 a8329 gain_cnaBRCA10_(MDM2,NUP107) 302 PI-103 PI3Ka, PRKDC (DNAPK) 5 43 2.32630161961136 NA 1.41694943900247 1.09488475480035 0.322064684202114 1.90892532826638 1.86113729070679 0.172657235154606 0.16871518201008 0.17304724686904 0.716478451009231 NA NA NA 0.735172895270333 99.482402686627 a8330 gain_cnaBRCA12_(TERT) 303 PIK-93 PI4K, PI3K 9 40 2.99573227355399 NA 2.63413588565929 2.82694024531946 -0.192804359660172 0.803840782710298 1.52754803478467 0.134784968596936 0.239853916107735 0.126218197575274 0.716498265634043 NA NA NA 0.598110043761463 99.482402686627 a8331 gain_cnaBRCA64_(SDHC) 258 STF-62247 stimulates autophagy 8 41 2.32630161961136 NA 4.7450470621495 4.60855916747628 0.136487894673216 1.15753547709814 0.929758023300765 0.141132802265177 0.117912493719313 0.146799372796662 0.716640330534967 NA NA NA 0.760569851268525 99.482402686627 a8332 TP53_mut 304 SB52334 ALK5 38 11 2.99573227355399 NA 4.2659540372265 4.42604020260071 -0.160086165374214 1.34179768361891 1.02525470896943 0.124968158552077 0.119307230388453 0.156142823801443 0.716750891672045 NA NA NA 0.676292203970381 99.482402686627 a8333 loss_cnaBRCA34 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 5 38 0.693147180559945 NA 3.05611833399479 2.88898453029515 0.167133803699643 0.72833262740455 0.984337746488423 0.173670003895668 0.229474552437989 0.169793147012685 0.716941138180709 NA NA NA 0.66091969425847 99.482402686627 a8334 loss_cnaBRCA7_(FAS,PTEN) 291 KIN001-266 MAP3K8 (COT) 4 45 2.99573227355399 NA 3.57122991482222 3.7970703639964 -0.225840449174178 1.1350295328009 1.19044417719838 0.190264046349586 0.198973192016312 0.189711078856026 0.716996669225489 NA NA NA 0.725341504206848 99.482402686627 a8335 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 256 JW-7-24-1 LCK 9 39 2.32630161961136 NA 1.96585404366721 1.80796491747948 0.157889126187731 0.601523674478294 1.25842181179382 0.134837723996023 0.26248198181837 0.125465980252414 0.717063612100892 NA NA NA 0.583247455512647 99.482402686627 a8336 gain_cnaBRCA64_(SDHC) 1008 Methotrexate Dihydrofolate reductase (DHFR) 9 36 -1.6094379124341 NA 0.801914984662725 0.65283384689498 0.149081137767746 1.48369655547072 0.987229635726906 0.135930414963554 0.100479533512463 0.151009585179213 0.717093574740407 NA NA NA 0.780789318636505 99.482402686627 a8337 loss_cnaBRCA60 333 T0901317 LXR 3 45 2.32630161961136 NA 4.57870709501609 4.74588481343061 -0.167177718414518 0.543902762739077 0.777857452548466 0.217349148983861 0.307366922669442 0.214920764552425 0.71715084822309 NA NA NA 0.656906049076624 99.482402686627 a8338 loss_cnaBRCA34 1259 BMN-673 PARP1 5 41 2.30258509299405 NA 3.06438446083272 3.33494701362634 -0.270562552793614 1.59611668828498 1.56400220894594 0.17266839520818 0.169513015420152 0.172993715255658 0.717222379759639 NA NA NA 0.734562306716776 99.482402686627 a8339 loss_cnaBRCA29_(MAP2K4) 231 FMK RSK 7 42 2.99573227355399 2.32630161961136 5.51314693914865 5.60191015707064 -0.088763217921989 0.858319836763598 0.548377584267211 0.148688801613271 0.103415083888404 0.161865146330884 0.717333412499059 NA NA NA 0.799000545629581 99.482402686627 a8340 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 136 Mitomycin C DNA crosslinker 6 42 2.77258872223978 NA 0.0726177520687139 -0.163865719686215 0.236483471754929 1.11836367081394 1.52662082430011 0.158961029956423 0.211454894258875 0.154906488887538 0.717358589572854 NA NA NA 0.657631118388724 99.482402686627 a8341 gain_cnaBRCA15 1230 IOX2 EGLN1 22 25 -2.30258509299405 NA 0.286714966693381 0.216680728451275 0.0700342382421058 0.52803522892481 0.753417930154821 0.106448150075468 0.13263175334856 0.0929553643987665 0.717457606210193 NA NA NA 0.711472102213101 99.482402686627 a8342 gain_cnaBRCA47_(EGFR) 1218 JQ1 BRD2, BRD3, BRD4 6 40 0 NA 2.55593557777075 2.4432888161428 0.112646761627947 0.369567999790187 0.738738094259085 0.159427907417096 0.304806589563759 0.152485383525437 0.717483484087995 NA NA NA 0.56569218049019 99.482402686627 a8343 CDH1_mut 1091 BMS-536924 IGF1R 5 42 1.38629436111989 NA 3.192821034801 3.00312140781275 0.189699626988247 0.825575526131645 1.12462827445707 0.172244542350435 0.229778646512346 0.168677625573505 0.717497611366154 NA NA NA 0.658504832712545 99.482402686627 a8344 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 261 TL-1-85 MAP3K7 (TAK1) 9 40 2.32630161961136 NA 4.158434826791 3.99474008475184 0.163694742039161 1.12449838757263 1.23775513391723 0.134261792385733 0.145571344386289 0.132251313328107 0.717549956375559 NA NA NA 0.70504301223843 99.482402686627 a8345 gain_cnaBRCA10_(MDM2,NUP107) 1004 Vinblastine Microtubules 3 42 -2.30258509299405 NA -3.71776355652218 -3.436831555588 -0.280932000934175 1.04345173766063 1.30263192059059 0.217484965347271 0.269233344288652 0.215664913851339 0.717699641638608 NA NA NA 0.694046650503919 99.482402686627 a8346 gain_cnaBRCA16 344 THZ-2-49 CDK9 16 33 2.99573227355399 NA 1.89585303483892 1.73166140048379 0.164191634355131 1.52396605590908 1.4629487988578 0.110738627062 0.107739692572868 0.112233343014686 0.717852906241001 NA NA NA 0.722749262147882 99.482402686627 a8347 gain_cnaBRCA15 151 QS11 ARFGAP 22 26 2.32630161961136 NA 3.67545876418274 3.83236546308647 -0.156906698903732 1.37748956702842 1.57813917519838 0.105313981344539 0.113907722177685 0.0994251339613371 0.71786005628908 NA NA NA 0.714743793549299 99.482402686627 a8348 gain_cnaBRCA13_(FGFR1,WHSC1L1) 51 Dasatinib ABL, SRC, KIT, PDGFR 3 9 0.246860077931526 NA 2.18217960346912 1.89308751813795 0.289092085331169 0.592329868959719 1.27044511601479 0.247767326971701 0.488059273186557 0.227551809745242 0.717906450563933 NA NA NA 0.60962491275229 99.482402686627 a8349 TP53_mut 1243 piperlongumine Increases ROS levels 37 10 2.30258509299405 NA 1.68657141152609 1.79784748894228 -0.111276077416187 0.834843909469912 0.949109207031533 0.129554398259845 0.133289679847868 0.11724264878245 0.717933785048842 NA NA NA 0.74136201568616 99.482402686627 a8350 gain_cnaBRCA58_(CCND1) 1264 SGC0946 Q8TEK3 (DOT1L) 9 37 -0.693147180559945 NA 1.88433261113068 1.96686040574581 -0.082527794615137 0.5624488998616 0.621096116444644 0.135102779202819 0.146729408903537 0.132874433489543 0.717970238864427 NA NA NA 0.70523498988723 99.482402686627 a8351 gain_cnaBRCA12_(TERT) 1243 piperlongumine Increases ROS levels 10 37 2.30258509299405 NA 1.62271314730358 1.73390501737439 -0.111191870070807 0.898364823366117 0.848767154457925 0.129456071388786 0.123771397965225 0.131003973806952 0.718138423441996 NA NA NA 0.7307125432553 99.482402686627 a8352 loss_cnaBRCA38 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 4 44 2.07944154167984 NA 3.41739754400381 3.19584035143558 0.221557192568228 0.903448375261656 1.18447112650622 0.189655920748029 0.245235033494926 0.187051577375082 0.718146386623697 NA NA NA 0.671943931617365 99.482402686627 a8353 PTEN_mut 308 XL-880 MET 9 40 1.63315443905142 NA 1.67126338244124 1.88743401460288 -0.21617063216164 1.53905788251923 1.62893144072758 0.133935772405533 0.14045646665855 0.132707016855838 0.718205602667471 NA NA NA 0.712863683536495 99.482402686627 a8354 loss_cnaBRCA34 273 CUDC-101 HDAC, EGFR 5 44 1.63315443905142 NA -0.269220715371836 0.000916511895876672 -0.270137227267713 0.668727520021752 1.63720239266693 0.171179824903418 0.403957096395444 0.164999286879658 0.718443660132883 NA NA NA 0.500685883240498 99.482402686627 a8355 gain_cnaBRCA13_(FGFR1,WHSC1L1) 301 PHA-793887 CDK-pan 11 37 2.32630161961136 NA 2.76368868038044 2.96941567596897 -0.205726995588525 1.27047460397072 1.7430232857009 0.124544501373912 0.161929246712645 0.118028828000309 0.718519014372817 NA NA NA 0.671273760519783 99.482402686627 a8356 gain_cnaBRCA13_(FGFR1,WHSC1L1) 86 A-443654 AKT1, AKT2, AKT3 3 9 0.0237165266173161 NA -1.51366213755686 -1.19561875904831 -0.318043378508552 0.934939654212222 1.36112148178026 0.247077086432261 0.340175301235388 0.23366274264702 0.718653786706299 NA NA NA 0.670226078442248 99.482402686627 a8357 gain_cnaBRCA8_(CHD4,WNK1) 222 BX-912 PDPK1 (PDK1) 4 45 2.32630161961136 NA 3.61972797150456 3.90725214061339 -0.287524169108823 1.79245357072059 1.50054742858271 0.189054341128765 0.160408154389871 0.191612849838672 0.718716894375508 NA NA NA 0.773802762219719 99.482402686627 a8358 CDH1_mut 1049 PD-173074 FGFR1, FGFR3 4 39 0.693147180559945 NA 3.13637762746936 2.91739336040484 0.218984267064522 1.15335645937827 1.15041293984967 0.190317077019645 0.189866944676036 0.190352750285596 0.718841768335733 NA NA NA 0.737560985568336 99.482402686627 a8359 loss_cnaBRCA20 258 STF-62247 stimulates autophagy 3 46 2.32630161961136 NA 4.82670094055718 4.618069555262 0.208631385295174 0.816181778937506 0.973276551175849 0.21572626851806 0.2556187735124 0.214359818946752 0.718952341052207 NA NA NA 0.707074625400645 99.482402686627 a8360 gain_cnaBRCA12_(TERT) 1375 Temozolomide DNA akylating agent 10 36 3.40119738166216 NA 5.97130669773574 5.88035350143898 0.0909531962967556 0.615356069820073 0.723262641922001 0.129463281995123 0.147805800182242 0.125754035982083 0.7189547148659 NA NA NA 0.696176737471604 99.482402686627 a8361 BRCA1_mut 219 AT-7519 CDK9 4 45 2.32630161961136 NA 1.98810160521334 1.64390262764656 0.344198977566781 2.52481414842441 1.76501820313129 0.188808897874395 0.136326461011626 0.195011573793485 0.719066099568013 NA NA NA 0.805511974635699 99.482402686627 a8362 gain_cnaBRCA61_(NOTCH2) 211 TL-2-105 CRAF 3 46 2.32630161961136 1.63315443905142 4.12911450649887 3.89310412108625 0.23601038541262 0.178029376958957 1.11830415186082 0.215560607308415 1.32568225224442 0.211043109354379 0.719158731263246 NA NA NA 0.238825647418443 99.482402686627 a8363 loss_cnaBRCA60 1261 rTRAIL TR10A (DR4), TR10B (DR5) 3 44 -2.30258509299405 NA -0.351574026214178 -0.126221618635372 -0.225352407578806 0.411378692524995 1.06400022698124 0.215917551702907 0.547797957632708 0.21179733036164 0.719159403249242 NA NA NA 0.473695138994873 99.482402686627 a8364 loss_cnaBRCA20 134 Etoposide TOP2 3 44 2.77258872223978 NA 2.91614539917765 2.44716689903571 0.468978500141935 1.03508316582038 2.21136576717654 0.215855323345604 0.453082917033273 0.212076404140381 0.71923680320123 NA NA NA 0.536691702469322 99.482402686627 a8365 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 175 PAC-1 CASP3 agonist 6 42 0.940007258491471 NA 2.23150537549261 2.42564986126604 -0.194144485773423 1.35602165251932 1.21393722716898 0.157818414133694 0.143172113374979 0.159929592262516 0.719301172812069 NA NA NA 0.750683816514445 99.482402686627 a8366 MLL3_mut 184 BMS-754807 IGF1R 3 45 0.940007258491471 NA 1.28559322912048 1.64962066971717 -0.364027440596693 1.71830992475782 1.68758722619767 0.215536727705172 0.211852027013113 0.21570881489598 0.719406094565205 NA NA NA 0.752518314351743 99.482402686627 a8367 loss_cnaBRCA7_(FAS,PTEN) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 4 45 1.63315443905142 NA 3.75085754917023 3.56117239588452 0.189685153285714 0.762577817508618 1.02048117466164 0.188554458199836 0.248742028591162 0.185878150421156 0.719428168364034 NA NA NA 0.667911556478465 99.482402686627 a8368 gain_cnaBRCA63 326 GSK690693 AKT 7 41 2.32630161961136 NA 2.69449924834082 2.98142100697717 -0.286921758636355 2.10856080017012 1.91535826647177 0.147772196769608 0.136074690667305 0.149800569250621 0.719501539500987 NA NA NA 0.744976916234515 99.482402686627 a8369 gain_cnaBRCA15 1166 QL-VIII-58 MTOR, ATR 14 12 2.30258509299405 NA -1.4441379736872 -1.60639768996016 0.162259716272962 1.36464735202775 0.781343454828049 0.14294280124414 0.11890230544313 0.20766759517896 0.71952123636118 NA NA NA 0.708914168051229 99.482402686627 a8370 gain_cnaBRCA47_(EGFR) 164 JQ12 HDAC 7 40 1.63315443905142 NA 1.78599455225429 1.54146367964191 0.244530872612375 2.23565436153831 1.54244897829411 0.148041586778899 0.109377762868549 0.158534172639419 0.71953771629716 NA NA NA 0.788979173808455 99.482402686627 a8371 loss_cnaBRCA33 54 CGP-082996 CDK4 4 8 1.63315443905142 NA 2.96747119122481 2.72989603283477 0.237575158390043 0.613270357778826 1.18940580285203 0.226199438913112 0.387390578032345 0.199742726847615 0.719544543085583 NA NA NA 0.65789576713849 99.482402686627 a8372 MLL3_mut 1009 ATRA Retinoic acid and retinoid X receptor agonist 3 42 2.30258509299405 NA 4.34067936520037 4.08920597918478 0.251473386015596 1.48664255758756 1.1469950639981 0.215858755504023 0.169155244972721 0.219245395127535 0.719718042270436 NA NA NA 0.799221488044792 99.482402686627 a8373 loss_cnaBRCA20 192 LFM-A13 BTK 3 45 2.77258872223978 NA 4.96537292047765 4.78414327118097 0.181229649296681 0.800016000373772 0.843785678478917 0.21525501710548 0.226532530864395 0.214781613292349 0.719756862200902 NA NA NA 0.737051493368717 99.482402686627 a8374 gain_cnaBRCA13_(FGFR1,WHSC1L1) 150 Bicalutamide ANDR (androgen receptor) 10 38 0.0237165266173161 NA 2.69887830008234 2.77935338644491 -0.0804750863625627 0.909107956886914 0.536825464284115 0.128288851177494 0.0885209350032927 0.149909219507462 0.719781211189218 NA NA NA 0.793863098691529 99.482402686627 a8375 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1038 NU-7441 PRKDC (DNAPK) 4 39 0.693147180559945 NA 3.05642942960943 2.87608917834608 0.180340251263341 0.329915582986379 0.983809409857863 0.18956688557521 0.546625441668776 0.183308117869492 0.719901567660251 NA NA NA 0.446997309527779 99.482402686627 a8376 loss_cnaBRCA7_(FAS,PTEN) 204 Tipifarnib Farnesyl-transferase (FNTA) 4 44 2.77258872223978 NA 1.8829603186134 1.5960689101275 0.286891408485902 0.130514314909677 1.57525961354956 0.188324195254056 2.19816047522792 0.18212325512456 0.720039231548556 NA NA NA 0.250071955107641 99.482402686627 a8377 gain_cnaBRCA9_(KRAS) 170 Shikonin unknown 4 43 2.77258872223978 NA 0.209417158158324 -0.0155370301960666 0.22495418835439 0.413064728424252 1.23111325660774 0.188381643188729 0.544597911355297 0.18272420278719 0.720253284150534 NA NA NA 0.439887584275166 99.482402686627 a8378 loss_cnaBRCA28_(GPS2) 134 Etoposide TOP2 4 43 2.77258872223978 NA 2.85153020149202 2.44227113835201 0.409259063140013 1.97812987869469 2.1859100312743 0.188366330287554 0.206891907122939 0.18722594127144 0.720275037023064 NA NA NA 0.716409876885787 99.482402686627 a8379 gain_cnaBRCA58_(CCND1) 203 BMS-345541 IKBKB 10 39 2.77258872223978 NA 3.63540068005287 3.50590431604883 0.129496364004036 1.13019102196009 0.984841240379874 0.127672203616452 0.114579183065399 0.131489582985057 0.720319335263919 NA NA NA 0.745664129653498 99.482402686627 a8380 loss_cnaBRCA24 346 THZ-2-102-1 CDK7 3 45 0.916290731874155 2.99573227355399 -1.85058325053366 -1.30079593122181 -0.549787319311848 1.21849556772752 2.60489145872971 0.214737849808246 0.451201739155435 0.211059588478959 0.720400963754304 NA NA NA 0.537722995484427 99.482402686627 a8381 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 225 Genentech Cpd 10 AURKA, AURKB 6 43 2.32630161961136 NA 3.24160503824222 2.98687159693109 0.254733441311122 1.30681887752059 1.65716305437827 0.156904839993554 0.194926355666383 0.153716582467917 0.720431729528013 NA NA NA 0.678311604404102 99.482402686627 a8382 NF1_mut 1243 piperlongumine Increases ROS levels 5 42 2.30258509299405 NA 1.84099250265904 1.69468225244269 0.146310250216352 0.830693629436925 0.861643565014493 0.170338621569884 0.176130218207555 0.169803682354305 0.720487363032853 NA NA NA 0.72573626225466 99.482402686627 a8383 ARID1A_mut 205 BMS-708163 g-secretase 5 43 2.32630161961136 0.940007258491471 5.0006384550426 4.8844238272216 0.116214627820998 0.464697612152028 0.700473877600394 0.170101057214119 0.250086561200099 0.165908582086049 0.720492869331293 NA NA NA 0.63568948732897 99.482402686627 a8384 loss_cnaBRCA60 293 MP470 PDGFR 3 45 2.99573227355399 NA 3.19350702592013 3.55412371877481 -0.360616692854677 2.00084095431224 1.66386161180288 0.214663136177185 0.180232562751912 0.216734787494695 0.72049403216013 NA NA NA 0.786815245619992 99.482402686627 a8385 loss_cnaBRCA7_(FAS,PTEN) 309 Y-39983 ROCK 4 45 2.99573227355399 NA 4.74703493554065 4.95168723762647 -0.204652302085829 0.445856852612115 1.12042027339179 0.187770050881826 0.459008986599274 0.182656728859694 0.720544792193561 NA NA NA 0.485891110779097 99.482402686627 a8386 loss_cnaBRCA28_(GPS2) 261 TL-1-85 MAP3K7 (TAK1) 4 45 2.32630161961136 NA 3.81455716957877 4.04349529228616 -0.228938122707393 0.444158122425493 1.25479035545024 0.18776833888555 0.51544283701757 0.182451292929524 0.720547229937872 NA NA NA 0.451911313016202 99.482402686627 a8387 loss_cnaBRCA57 293 MP470 PDGFR 5 43 2.99573227355399 NA 3.78749230701798 3.5018285322683 0.28566377474968 1.67899507718099 1.68000867657218 0.17004600172778 0.170139733363188 0.170037082982534 0.72057942079 NA NA NA 0.733569595997254 99.482402686627 a8388 loss_cnaBRCA28_(GPS2) 175 PAC-1 CASP3 agonist 4 44 0.940007258491471 NA 2.18953316279968 2.42064076761206 -0.231107604812377 1.59530454454014 1.20058527582701 0.187862663528969 0.144867389492077 0.192495784735642 0.720695643147789 NA NA NA 0.794252480294817 99.4865862185056 a8389 loss_cnaBRCA17 228 KIN001-102 AKT1 11 38 2.32630161961136 NA 1.80862810794361 1.98280439514857 -0.174176287204962 0.99946267216882 1.50807418284165 0.123070991211149 0.174269927287031 0.115495835143045 0.720863982231128 NA NA NA 0.657546692236331 99.4973249956732 a8390 gain_cnaBRCA31 1199 Tamoxifen ER 15 32 1.6094379124341 NA 3.94261896228472 3.83474112542238 0.107877836862342 0.983737223025106 0.947797578518027 0.112475483018325 0.109661233038032 0.113819489844044 0.720945294683218 NA NA NA 0.725740390420617 99.4973249956732 a8391 loss_cnaBRCA60 136 Mitomycin C DNA crosslinker 3 45 2.77258872223978 NA -0.432445518590265 -0.114429270191954 -0.318016248398311 0.263440565866511 1.52014850038091 0.213756653857127 1.20716506720326 0.209200777633648 0.721623548893357 NA NA NA 0.260071406636599 99.5502766024175 a8392 gain_cnaBRCA9_(KRAS) 286 KIN001-236 TIE2 4 45 2.32630161961136 NA 4.407648941376 4.55187777313418 -0.144228831758189 0.80503153745536 0.769342877497102 0.18690475929969 0.179159231716666 0.18747015924474 0.721777270706704 NA NA NA 0.750055559959175 99.5502766024175 a8393 loss_cnaBRCA22_(SYNCRIP,ZNF292) 6 PHA-665752 MET 4 10 0.693147180559945 NA 2.98435584493818 2.816407721267 0.167948123671182 0.775840321549142 0.779684001314642 0.215670684602975 0.216472538235491 0.215405373700116 0.721790591702589 NA NA NA 0.728203854961457 99.5502766024175 a8394 CDH1_mut 266 Zibotentan, ZD4054 Endothelin A Receptor 4 45 2.99573227355399 NA 5.65701356043859 5.74959723553094 -0.092583675092345 0.543618275920036 0.491978722057175 0.186873239500266 0.170310085575496 0.188186340062051 0.721822180049242 NA NA NA 0.761226878976323 99.5502766024175 a8395 loss_cnaBRCA33 155 AP-24534 ABL 6 41 -0.669430653942629 NA 1.28959546717005 1.46815453560822 -0.178559068438165 1.08285918288643 1.14908844646102 0.156367496128474 0.16489592669123 0.155391927390877 0.722211905422976 NA NA NA 0.71967915279185 99.5502766024175 a8396 gain_cnaBRCA15 1009 ATRA Retinoic acid and retinoid X receptor agonist 21 24 2.30258509299405 NA 4.03956130484021 4.16407924248822 -0.124517937648008 1.26167415835419 1.07393423998933 0.106880099245058 0.0986926274296034 0.115945588669605 0.722325696009676 NA NA NA 0.725358359526623 99.5502766024175 a8397 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1230 IOX2 EGLN1 18 29 -2.30258509299405 NA 0.292977567029093 0.222453492138365 0.0705240748907277 0.82290410387501 0.533479771178915 0.107186739059358 0.0857014499728871 0.132196343143208 0.722602114885505 NA NA NA 0.748676725977226 99.5502766024175 a8398 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1199 Tamoxifen ER 9 38 1.6094379124341 NA 3.97185358118218 3.84485047939861 0.127003101783565 0.920044929399252 0.967385634359692 0.132413476839701 0.138040108396111 0.131284874689738 0.722621111877849 NA NA NA 0.718525679258744 99.5502766024175 a8399 gain_cnaBRCA63 295 NVP-BHG712 EPHB4 7 42 2.32630161961136 NA 3.73221061157268 3.91245785909672 -0.180247247524036 2.31575257027631 0.983697170570262 0.145781764486635 0.0778352790525153 0.183234488129659 0.722622128555177 NA NA NA 0.845541301513008 99.5502766024175 a8400 POLR2B_mut 140 Vinorelbine Microtubules 3 44 -2.74887219562247 NA -3.93035770608563 -3.57728025729539 -0.35307744879024 0.768319784353689 1.68664935107565 0.21312355534863 0.459544913433733 0.209336604887713 0.722637512988216 NA NA NA 0.532742054972883 99.5502766024175 a8401 gain_cnaBRCA19 1025 SB 216763 GSK3A, GSK3B 3 36 2.30258509299405 NA 5.04641706608436 4.87605668884106 0.170360377243299 0.875705867006406 0.787769345240194 0.214891997633929 0.194540637058508 0.216256672429105 0.722673143432925 NA NA NA 0.771885382187887 99.5502766024175 a8402 loss_cnaBRCA7_(FAS,PTEN) 1016 Temsirolimus MTOR 4 40 -1.6094379124341 NA -2.00786114638738 -1.72524894038808 -0.282612205999303 1.03148736243096 1.53922180375318 0.187330032910097 0.273985136699355 0.183607200281462 0.722712614434369 NA NA NA 0.643598777088386 99.5502766024175 a8403 loss_cnaBRCA33 1031 Elesclomol HSP70 5 39 -1.6094379124341 NA -3.24775963215148 -2.94294053703475 -0.304819095116727 2.12397367296343 1.75947234838044 0.169591325350926 0.143513593881526 0.173244606769357 0.722863214800376 NA NA NA 0.771422653275819 99.5502766024175 a8404 loss_cnaBRCA57 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 5 40 -0.669430653942629 NA -3.85448661588027 -3.44015459951719 -0.414332016363078 1.77179410750063 2.50614528270878 0.169312239085492 0.233848851065179 0.165326415520191 0.722881354095977 NA NA NA 0.655973324418539 99.5502766024175 a8405 gain_cnaBRCA8_(CHD4,WNK1) 135 Gemcitabine DNA replication 3 44 0.0237165266173161 NA 0.279041592304771 -0.313014547146479 0.59205613945125 4.40484961511077 2.68151644868089 0.212902440942913 0.134410068716128 0.220791537468472 0.722913021801328 NA NA NA 0.838603300260486 99.5502766024175 a8406 BRCA2_mut 1133 JNJ-26854165 MDM2 5 38 2.30258509299405 NA 2.83697972596656 2.98616263017409 -0.149182904207532 0.596265084062014 0.903637786706647 0.169835232875143 0.250195606275037 0.165091485108471 0.72292146502799 NA NA NA 0.639557301396729 99.5502766024175 a8407 TP53_mut 1024 CEP-701 FLT3, JAK2, NTRK1, RET 35 10 0.693147180559945 NA 0.666655065707299 0.481767420625127 0.184887645082173 1.38487439485742 1.65348914880127 0.127929280767788 0.133504992054682 0.111816666723341 0.723003122514889 NA NA NA 0.752097725187145 99.5502766024175 a8408 loss_cnaBRCA36_(FAT1,IRF2) 1373 Dabrafenib BRAF 9 37 2.30258509299405 NA 4.03912260886603 4.25727017758962 -0.218147568723587 0.977938207881335 1.760004327017 0.132556875666589 0.223068867711177 0.12394717750116 0.723056575972849 NA NA NA 0.621597517422958 99.5502766024175 a8409 loss_cnaBRCA28_(GPS2) 223 ZSTK474 PI3K 4 45 1.63315443905142 2.32630161961136 0.663779982499008 0.934432003895511 -0.270652021396503 0.884219667139289 1.48748444097563 0.185828283574061 0.306091383685394 0.18195284195308 0.723311590424331 NA NA NA 0.609302321061591 99.5502766024175 a8410 loss_cnaBRCA57 1164 XMD8-92 MAP2K5 (ERK5) 5 21 2.30258509299405 NA 4.07416848048687 3.83932720252274 0.234841277964131 0.403427836623502 1.43210190160702 0.178226295593238 0.582114709608638 0.163983636709515 0.723352987070556 NA NA NA 0.521665587428356 99.5502766024175 a8411 PTEN_mut 1067 CCT007093 PPM1D 8 38 1.88706964903238 NA 3.97217452374819 4.10952289762375 -0.137348373875555 0.704708460938615 1.03748440688451 0.138450720270018 0.194900985994432 0.132385964515845 0.723600927670049 NA NA NA 0.654679204270044 99.5502766024175 a8412 gain_cnaBRCA10_(MDM2,NUP107) 1149 TW 37 BCL2, BCL2L1 3 40 1.6094379124341 NA -0.391208383414827 -0.123722431724901 -0.267485951689926 0.582699588096521 1.28072353160032 0.213015996119887 0.459046062764023 0.20885534238267 0.723776399729834 NA NA NA 0.536107768959306 99.5502766024175 a8413 gain_cnaBRCA14_(RAD21) 224 AS605240 PI3Kgamma 21 28 2.99573227355399 2.32630161961136 3.17704971111517 3.34016202798038 -0.163112316865215 1.23698322751738 1.80801672853663 0.102567886758396 0.131862998007322 0.0902161546908 0.723950303496358 NA NA NA 0.709662400293722 99.5502766024175 a8414 PIK3CA_mut 1114 Cetuximab EGFR 16 29 4.18661983833127 NA 6.34556979264134 6.24783485512852 0.0977349375128158 0.828823794028245 0.911527696557205 0.110615296783847 0.117920043098431 0.107221028918766 0.724179264762082 NA NA NA 0.717180055339673 99.5502766024175 a8415 gain_cnaBRCA15 9 MG-132 Proteasome 6 8 0 NA 0.14774014467642 0.465177166250807 -0.317437021574387 1.95821867844664 1.34146297904113 0.195092787953908 0.162104991167889 0.236634947467048 0.724198844342339 NA NA NA 0.741118128655909 99.5502766024175 a8416 loss_cnaBRCA36_(FAT1,IRF2) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 9 34 0.693147180559945 NA 2.80707101166793 2.93524602106407 -0.12817500939614 0.810892831434737 0.995719347307987 0.133176199259584 0.15806652177373 0.128726040869521 0.724211868022814 NA NA NA 0.694119574921053 99.5502766024175 a8417 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 9 39 2.07944154167984 NA 3.33887586384799 3.18555597088587 0.153319892962125 0.659507965449035 1.24926223854834 0.131235420449541 0.232476180720176 0.122728349766087 0.724299926649035 NA NA NA 0.610819552679925 99.5502766024175 a8418 loss_cnaBRCA29_(MAP2K4) 177 GSK-650394 SGK3 7 40 2.77258872223978 NA 4.2256530542627 3.97747631870346 0.248176735559236 1.44038718348118 1.74405598667286 0.145413941711924 0.172298628039326 0.142298605925308 0.724304158617465 NA NA NA 0.693377313847088 99.5502766024175 a8419 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 3 Rapamycin MTOR 4 10 -2.30258509299405 NA -3.15641636082594 -2.57656244399163 -0.579853916834318 3.79124780874484 2.24352629555581 0.213614433350003 0.152945401114861 0.258456483430993 0.72432074930286 NA NA NA 0.789172663538473 99.5502766024175 a8420 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 156 AZD6482 PI3Kbeta 7 40 1.63315443905142 NA 2.235356325427 2.02145166033924 0.213904665087759 1.44757798033395 1.47469273580536 0.145403947710553 0.1477672830022 0.14505032804067 0.724322308580703 NA NA NA 0.728046152353982 99.5502766024175 a8421 loss_cnaBRCA17 5 Sunitinib PDGFRA, PDGFRB, KDR, KIT, FLT3 3 9 2.07944154167984 NA 3.51554227014978 3.16869089827876 0.346851371871024 1.11619310158658 1.50323631412835 0.241841728714049 0.3107449520858 0.230736424214276 0.724332286547849 NA NA NA 0.689587162380598 99.5502766024175 a8422 gain_cnaBRCA64_(SDHC) 275 I-BET BRD2, BRD3, BRD4 8 41 2.99573227355399 NA 3.88204354755249 4.06955520797164 -0.187511660419156 1.8181767578399 1.2723788257155 0.137115646236151 0.103131700265452 0.147370937514393 0.72436166837369 NA NA NA 0.787231258311478 99.5502766024175 a8423 BRCA1_mut 1166 QL-VIII-58 MTOR, ATR 3 23 2.30258509299405 NA -1.29919539815309 -1.54770077029058 0.248505372137491 1.48026787946294 1.09852652156934 0.218898909406493 0.167878649253439 0.226216998186333 0.724507270798312 NA NA NA 0.802137543102872 99.5502766024175 a8424 BRCA2_mut 299 OSI-027 MTORC1/2 6 42 2.99573227355399 NA 0.998601511680527 1.30759357105186 -0.308992059371333 2.06169596336803 1.98922644264418 0.15471023022071 0.14987275760416 0.155332772955001 0.724594907854741 NA NA NA 0.741220639877089 99.5502766024175 a8425 gain_cnaBRCA64_(SDHC) 1022 AZD7762 CHEK1, CHEK2 9 36 0.693147180559945 NA 0.732262014851129 0.947872853310239 -0.21561083845911 1.80454082912927 1.59183771481392 0.131992453898397 0.119482382985564 0.135447751019214 0.724940227405594 NA NA NA 0.748926899828392 99.5502766024175 a8426 loss_cnaBRCA17 60 BI-2536 PLK1, PLK2, PLK3 3 9 -1.36257783450257 NA -1.79082254147747 -1.40020040835921 -0.390622133118254 1.44538512659282 1.66024245573099 0.241191337229083 0.270254706466409 0.23528017354927 0.725038964660655 NA NA NA 0.716555930182875 99.5502766024175 a8427 loss_cnaBRCA36_(FAT1,IRF2) 1030 KU-55933 ATM 8 34 2.30258509299405 NA 4.11766844009968 4.24691839385923 -0.129249953759548 0.562731668523119 0.989277927046983 0.139145850684466 0.229683099404663 0.130650801181182 0.725121289907925 NA NA NA 0.626816765094962 99.5502766024175 a8428 gain_cnaBRCA12_(TERT) 205 BMS-708163 g-secretase 9 39 2.32630161961136 0.940007258491471 4.96915256241347 4.87977035343643 0.0893822089770371 0.554998526549369 0.707284206167771 0.130820657201201 0.161049452748567 0.126373822853094 0.725134754647409 NA NA NA 0.686245247918533 99.5502766024175 a8429 gain_cnaBRCA30_(CRNKL1,FOXA2) 292 Masitinib KIT 5 43 2.99573227355399 NA 3.84633074642476 4.02939675754919 -0.183066011124432 1.169057383006 1.08911648321445 0.166985431749448 0.156592836062258 0.168086714273321 0.72539665934895 NA NA NA 0.752554104296097 99.5502766024175 a8430 loss_cnaBRCA60 282 EKB-569 EGFR 3 44 0.916290731874155 2.99573227355399 1.99848920885886 1.54940233227903 0.449086876579835 0.838916912707912 2.17073305211265 0.210907830790136 0.535317466815924 0.206882590258054 0.725399982684912 NA NA NA 0.483230706613769 99.5502766024175 a8431 PTEN_mut 310 YM201636 FYV1 9 40 1.63315443905142 NA 2.52347123110262 2.39018664065622 0.133284590446395 0.929010806662982 1.04146916004681 0.13026242923368 0.143469364931453 0.127977472170567 0.725607622333216 NA NA NA 0.710089699587675 99.5502766024175 a8432 TP53_mut 222 BX-912 PDPK1 (PDK1) 38 11 2.32630161961136 NA 3.92504293149566 3.74123880152596 0.183804129969707 1.43517738570359 1.80322679732966 0.120847209678884 0.128070670427682 0.10193067796125 0.72569580250772 NA NA NA 0.760592815358644 99.5502766024175 a8433 loss_cnaBRCA60 134 Etoposide TOP2 3 44 2.77258872223978 NA 2.04903972540293 2.50628774042944 -0.457248015026511 1.41617475623417 2.20168099134461 0.210441053491754 0.322875417044155 0.207681320238525 0.725982413224302 NA NA NA 0.643639092195117 99.5502766024175 a8434 loss_cnaBRCA33 89 Parthenolide NFKB1 5 9 1.6094379124341 NA 3.43518562790919 3.14691009075106 0.288275537158127 1.24039337934427 1.53142089224865 0.200058319017181 0.232406542923119 0.188240567055893 0.7260706759814 NA NA NA 0.71013201833613 99.5502766024175 a8435 loss_cnaBRCA38 268 YM155 BIRC5 (Survivin) 4 45 1.63315443905142 NA -3.3240509667655 -3.61971373844004 0.295662771674532 2.44966162533799 1.53391103200376 0.183867482835261 0.120695351805471 0.192750925904943 0.72610930206822 NA NA NA 0.826767822501775 99.5502766024175 a8436 gain_cnaBRCA62 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 10 39 1.63315443905142 NA 3.67667428887883 3.55101141340246 0.125662875476369 1.12358824229774 0.976160695675834 0.12490529221748 0.111840682151843 0.128731750861335 0.726126251208409 NA NA NA 0.751408917417961 99.5502766024175 a8437 gain_cnaBRCA47_(EGFR) 276 CAY10603 HDAC6 7 42 2.99573227355399 NA 1.05255122504362 1.19603783211777 -0.143486607074155 0.747749537088141 1.02935261372817 0.143797461202828 0.191891268342225 0.139394999498244 0.726240022947364 NA NA NA 0.667264710465693 99.5502766024175 a8438 gain_cnaBRCA8_(CHD4,WNK1) 1495 AZD-2281 PARP1, PARP2 3 42 2.30258509299405 NA 3.77524695480818 4.01465160710869 -0.239404652300507 0.684608613574934 1.15496882859681 0.210481741150182 0.349695647342747 0.207282349421814 0.726406167980391 NA NA NA 0.620658143366823 99.5502766024175 a8439 gain_cnaBRCA10_(MDM2,NUP107) 291 KIN001-266 MAP3K8 (COT) 5 44 2.99573227355399 NA 3.60172183732026 3.79873811028467 -0.197016272964413 0.215069415055064 1.23935342899064 0.165964111400247 0.916058998505069 0.158966980972383 0.726662292060051 NA NA NA 0.354222659097275 99.5502766024175 a8440 PIK3CA_mut 1031 Elesclomol HSP70 16 28 -1.6094379124341 NA -3.1037093782275 -2.9055046090526 -0.198204769174902 1.79075626854786 1.80116171635044 0.110269829218877 0.110682158513748 0.1100427392919 0.726702894970045 NA NA NA 0.726863124357666 99.5502766024175 a8441 loss_cnaBRCA22_(SYNCRIP,ZNF292) 226 GSK1070916 AURKB 19 30 0.940007258491471 2.32630161961136 2.2803053236395 2.48225455340342 -0.201949229763917 2.24913636674419 1.75629802276565 0.103048803264875 0.0897896778292084 0.114985741113519 0.726810168807797 NA NA NA 0.741760383351422 99.5502766024175 a8442 gain_cnaBRCA31 273 CUDC-101 HDAC, EGFR 16 33 1.63315443905142 NA 0.0871523544859584 -0.0818246886429073 0.168977043128866 2.12258717325784 1.24356677722061 0.107067783854023 0.0796090004018597 0.135880956474675 0.726812946317665 NA NA NA 0.771128951333062 99.5502766024175 a8443 BRCA2_mut 257 NPK76-II-72-1 PLK3 6 43 2.32630161961136 NA 3.26475015412761 3.50885008445555 -0.244099930327944 1.97742397971711 1.54247960953704 0.153098291163572 0.123443395463862 0.158251641589745 0.726930870088676 NA NA NA 0.78155166110183 99.5502766024175 a8444 gain_cnaBRCA16 186 Bexarotene Retinioic acid X family agonist 15 32 2.07944154167984 NA 3.51853770415082 3.64465597382818 -0.126118269677361 1.57637148251607 0.88816960558465 0.109916792840475 0.0800054245310638 0.141997957241896 0.727028397195656 NA NA NA 0.775758617757947 99.5502766024175 a8445 PIK3CA_mut 1164 XMD8-92 MAP2K5 (ERK5) 10 16 2.30258509299405 NA 3.99976753251745 3.81243989563984 0.187327636877612 1.75486818540616 0.964712267078356 0.142155576389995 0.106747411820139 0.194179801864587 0.727433105702756 NA NA NA 0.761990807786702 99.5502766024175 a8446 gain_cnaBRCA19 1047 Nutlin-3a MDM2 3 40 2.07944154167984 1.38629436111989 4.0092439538179 4.22177211412662 -0.212528160308723 0.682208676844408 1.02624855370548 0.209970135690356 0.311529547369265 0.20709228728396 0.727561990069274 NA NA NA 0.655212775171432 99.5502766024175 a8447 gain_cnaBRCA62 1114 Cetuximab EGFR 7 38 4.18661983833127 NA 6.39018912223877 6.26276325329782 0.127425868940948 0.550431248587741 0.926393979422955 0.144213761063791 0.231501880149226 0.137550407031273 0.727582603459216 NA NA NA 0.627637051708504 99.5502766024175 a8448 gain_cnaBRCA63 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 7 41 0.246860077931526 2.32630161961136 -0.468615780467997 -0.230179984443076 -0.238435796024921 1.94188784268053 1.61784935541725 0.143316728531663 0.122785565048798 0.147378243361495 0.727606092335377 NA NA NA 0.767079946461688 99.5502766024175 a8449 gain_cnaBRCA64_(SDHC) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 9 37 2.30258509299405 NA 1.30821045968154 1.43870680989156 -0.13049635021002 1.49450053253578 0.854351400857616 0.130281500539933 0.0873177007094146 0.152743180474714 0.727613180814678 NA NA NA 0.806423777069248 99.5502766024175 a8450 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1164 XMD8-92 MAP2K5 (ERK5) 3 23 2.30258509299405 NA 3.6323661140983 3.91737457883117 -0.285008464732869 1.31110075449267 1.3183756232458 0.216280736515966 0.217381054626235 0.216181534084487 0.727662324273541 NA NA NA 0.750523613439192 99.5502766024175 a8451 loss_cnaBRCA17 328 SNX-2112 HSP90 11 37 0.940007258491471 NA 0.226869889458038 0.47383646325439 -0.246966573796352 2.09466781756113 2.04077455083192 0.120318263704854 0.117902500685718 0.121016098370923 0.727671687830087 NA NA NA 0.734316551248113 99.5502766024175 a8452 gain_cnaBRCA48 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 5 44 3.68887945411394 NA 3.28098171490194 3.47974008297126 -0.198758368069325 1.69485262920437 1.14600349160103 0.165286724192428 0.117271770208499 0.173436092931662 0.72773209203775 NA NA NA 0.809656335793703 99.5502766024175 a8453 gain_cnaBRCA9_(KRAS) 133 Doxorubicin DNA intercalating 4 44 0.0237165266173161 NA -1.34022260843443 -1.00250156308844 -0.337721045345991 1.81031670402058 1.8490976492302 0.18288870016334 0.186553570762473 0.182641000861467 0.727783244110862 NA NA NA 0.741341194887392 99.5502766024175 a8454 gain_cnaBRCA30_(CRNKL1,FOXA2) 1091 BMS-536924 IGF1R 5 42 1.38629436111989 NA 3.18637594137966 3.0038886808391 0.18248726054056 1.29938123937919 1.08021075469298 0.165677615131447 0.140441661777222 0.16893671882801 0.727817472623595 NA NA NA 0.775699009851429 99.5502766024175 a8455 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 295 NVP-BHG712 EPHB4 9 40 2.32630161961136 NA 4.01696740562634 3.85739994281085 0.159567462815484 0.734896036749438 1.31595354624114 0.129049142206406 0.217129301065871 0.121256151686561 0.728058338037453 NA NA NA 0.624620736529826 99.5502766024175 a8456 gain_cnaBRCA10_(MDM2,NUP107) 1170 CCT018159 HSP90 3 40 2.30258509299405 NA 3.57667904875106 3.3252896123696 0.251389436381459 0.763482175905787 1.21775318654757 0.209562553795277 0.329266935515833 0.206437100028593 0.728069084798228 NA NA NA 0.639363990118344 99.5502766024175 a8457 gain_cnaBRCA15 71 Pyrimethamine Dihydrofolate reductase (DHFR) 6 8 2.99573227355399 NA 4.68248201045966 4.48486221667009 0.19761979378957 1.04817773197285 1.01414668457106 0.19215058396286 0.188536531316703 0.194863126602987 0.728171266621307 NA NA NA 0.730221252579661 99.5502766024175 a8458 gain_cnaBRCA14_(RAD21) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 21 28 1.63315443905142 NA 3.63467810015904 3.53314099671945 0.101537103439596 1.11117803691129 0.920537248972295 0.100922880317916 0.0913778891111235 0.110302004131776 0.72819527762523 NA NA NA 0.735533037011125 99.5502766024175 a8459 gain_cnaBRCA63 288 KIN001-055 JAK3, MNK1 7 42 2.32630161961136 NA 4.4442208155522 4.32147135197073 0.122749463581472 1.00407425472411 0.837404992582135 0.142652091892147 0.122251380317683 0.14658315232033 0.72833120451208 NA NA NA 0.767836149755099 99.5502766024175 a8460 MACF1_mut 1018 ABT-888 PARP1, PARP2 3 42 1.6094379124341 NA 4.53349344748815 4.39376067377435 0.139732773713804 0.685842829840152 0.667978923186459 0.208924215402301 0.203738768758975 0.209187399277864 0.728347541987084 NA NA NA 0.761677720617456 99.5502766024175 a8461 ASH1L_mut 346 THZ-2-102-1 CDK7 3 45 0.916290731874155 2.99573227355399 -0.835000157658361 -1.36850147074683 0.533501313088466 3.4628538712953 2.5117749380058 0.208359661655139 0.154064056098592 0.212400125909383 0.728361345788237 NA NA NA 0.816186042342792 99.5502766024175 a8462 loss_cnaBRCA7_(FAS,PTEN) 1264 SGC0946 Q8TEK3 (DOT1L) 4 42 -0.693147180559945 NA 2.05266105070092 1.94100438833256 0.111656662368357 0.156173888853907 0.631466842042124 0.182767428206145 0.714950899844768 0.176821101179702 0.728544755202104 NA NA NA 0.383946946767937 99.5502766024175 a8463 loss_cnaBRCA22_(SYNCRIP,ZNF292) 308 XL-880 MET 19 30 1.63315443905142 NA 1.94877407435977 1.78373412044169 0.165039953918084 1.77898454381566 1.50279281712981 0.102244992815579 0.0927719998983788 0.109822160471391 0.728854151831682 NA NA NA 0.739256305379848 99.5502766024175 a8464 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 208 SB-715992 KIF11 7 42 -2.05572501506252 NA -1.44958329790254 -1.20495194784445 -0.244631350058092 2.53633496528166 1.56334498540486 0.142350886467018 0.096450726503676 0.156479441416918 0.728881484067266 NA NA NA 0.811870963675587 99.5502766024175 a8465 gain_cnaBRCA61_(NOTCH2) 281 CH5424802 ALK 3 45 1.63315443905142 NA 3.78409290006087 3.56131607444641 0.222776825614466 1.26813939092201 1.06184718119705 0.207883532929544 0.175672191250597 0.20980121203818 0.72895681301689 NA NA NA 0.792016647487152 99.5502766024175 a8466 gain_cnaBRCA63 89 Parthenolide NFKB1 3 11 1.6094379124341 NA 3.51138814578852 3.17854131990363 0.332846825884888 1.96603668892015 1.31117036646738 0.230962342819409 0.169298379710149 0.253854750227203 0.729045556444508 NA NA NA 0.803057774596194 99.5502766024175 a8467 gain_cnaBRCA10_(MDM2,NUP107) 1007 Docetaxel Microtubules 3 42 -4.38202663467388 NA -4.88941758812839 -4.56569837462706 -0.323719213501328 1.06555882661931 1.57368622319069 0.208348171012897 0.303802291731176 0.205707598332391 0.72906600908536 NA NA NA 0.661890595315124 99.5502766024175 a8468 loss_cnaBRCA34 1022 AZD7762 CHEK1, CHEK2 5 40 0.693147180559945 NA 0.664634354182192 0.934765227047945 -0.270130872865753 1.21499498909084 1.67059520384964 0.165360986934307 0.222330853453056 0.161697383210054 0.729082113899596 NA NA NA 0.670281768685394 99.5502766024175 a8469 gain_cnaBRCA15 266 Zibotentan, ZD4054 Endothelin A Receptor 22 27 2.99573227355399 NA 5.71472689148887 5.76429400844042 -0.049567116951545 0.582515022053806 0.411954201611719 0.100040137206957 0.0850915685861344 0.120321911410589 0.729160643155134 NA NA NA 0.738477134743342 99.5502766024175 a8470 gain_cnaBRCA47_(EGFR) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 7 42 3.68887945411394 NA 3.60600647058079 3.4350339745519 0.170972496028886 1.59783153750068 1.13316542876308 0.142178025364932 0.10700282978287 0.150880437832906 0.729197353393274 NA NA NA 0.793473766983839 99.5502766024175 a8471 loss_cnaBRCA29_(MAP2K4) 287 KIN001-244 PDPK1 (PDK1) 7 42 2.99573227355399 NA 3.36253996293469 3.49736705501094 -0.134827092076246 0.60296139883218 0.989042366422456 0.142140780802888 0.223608165194953 0.136320845955204 0.729265416646957 NA NA NA 0.631727322277832 99.5502766024175 a8472 TP53_mut 1020 Lenalidomide TNFA 35 10 1.6094379124341 NA 4.27456812058023 4.18528117394785 0.0892869466323827 0.71035411221534 0.732523453332469 0.12486792704422 0.12569357324325 0.121889539817721 0.729359131079868 NA NA NA 0.73720166032655 99.5502766024175 a8473 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 170 Shikonin unknown 6 41 2.77258872223978 NA -0.154866629790382 0.0267994173888956 -0.181666047179277 1.47591156920322 1.15422723164682 0.152116429957239 0.123087352230291 0.157391926128862 0.729453603436744 NA NA NA 0.782527486672609 99.5502766024175 a8474 gain_cnaBRCA19 1008 Methotrexate Dihydrofolate reductase (DHFR) 4 41 -1.6094379124341 NA 0.864866627933276 0.664872849718309 0.199993778214967 0.644205742357039 1.12351986676845 0.182326838103797 0.310450163767904 0.178006445751782 0.729486089676054 NA NA NA 0.608962313856798 99.5502766024175 a8475 loss_cnaBRCA36_(FAT1,IRF2) 203 BMS-345541 IKBKB 9 40 2.77258872223978 NA 3.63860103500003 3.50842164528582 0.130179389714207 1.07961776564383 1.00047449769001 0.128333712843826 0.120579147413876 0.130117649190237 0.729504780365836 NA NA NA 0.746584460627011 99.5502766024175 a8476 gain_cnaBRCA27_(CLTC,PPM1D) 1016 Temsirolimus MTOR 10 34 -1.6094379124341 NA -1.60497005268318 -1.79387357865414 0.188903525970964 1.32201127775657 1.55579183570144 0.12520543713288 0.142891009440956 0.121419538035945 0.729544285471022 NA NA NA 0.707984053161019 99.5502766024175 a8477 loss_cnaBRCA24 229 LY317615 PRKCB (PKCbeta) 3 46 2.99573227355399 2.32630161961136 3.67447099482166 3.33798168573503 0.336489309086626 0.462931450813538 1.65660127394928 0.207225696114944 0.726866382690769 0.203120276664069 0.729569831851449 NA NA NA 0.385759708975639 99.5502766024175 a8478 gain_cnaBRCA12_(TERT) 295 NVP-BHG712 EPHB4 9 40 2.32630161961136 NA 3.75720603200248 3.91584625187622 -0.158640219873734 1.1257360323826 1.25802152378174 0.128297305372503 0.140921330854068 0.126102945676832 0.729578414968335 NA NA NA 0.714812106863564 99.5502766024175 a8479 TP53_mut 179 5-Fluorouracil DNA antimetabolite 38 11 3.46573590279973 NA 4.08493955493376 3.8913322388328 0.193607316100965 1.52254628442084 1.97037801141109 0.118910386831797 0.127160217119187 0.0982589711109867 0.729913330321284 NA NA NA 0.76801309021867 99.5502766024175 a8480 gain_cnaBRCA27_(CLTC,PPM1D) 1072 BMS-708163 g-secretase 10 36 1.6094379124341 NA 3.59087584492947 3.71018697001798 -0.119311125088512 1.05894997765216 0.934395061069311 0.1241290481234 0.112669273909464 0.127688094746535 0.730056952623102 NA NA NA 0.751723781142666 99.5502766024175 a8481 PIK3CA_mut 91 KIN001-135 IKKE 4 10 1.6094379124341 NA 3.76531910507168 3.67868606225363 0.0866330428180477 0.383628253680955 0.424561872525595 0.208901596514286 0.225825501606814 0.20405280931774 0.73013255997478 NA NA NA 0.72374679784888 99.5502766024175 a8482 POLR2B_mut 1010 Gefitinib EGFR 3 42 -0.693147180559945 NA 1.19692673017607 1.41439574928603 -0.217469019109955 0.65258444597536 1.06421958161213 0.207377448973462 0.333242725062077 0.204346004215147 0.730277292122438 NA NA NA 0.63543390167259 99.5502766024175 a8483 loss_cnaBRCA24 204 Tipifarnib Farnesyl-transferase (FNTA) 3 45 2.77258872223978 NA 1.91539164724453 1.60028218618511 0.31510946105942 1.18144570957552 1.53729428370066 0.20682555735727 0.266715142731895 0.204976668683676 0.730280567435293 NA NA NA 0.696773380899097 99.5502766024175 a8484 loss_cnaBRCA18 1262 UNC1215 LMBL3 15 31 0 NA 2.8014868533787 2.73624617587816 0.0652406775005314 0.542460915678344 0.622065842208464 0.109118599625731 0.120267978051374 0.104877447166868 0.730295097069017 NA NA NA 0.718187335157273 99.5502766024175 a8485 gain_cnaBRCA13_(FGFR1,WHSC1L1) 60 BI-2536 PLK1, PLK2, PLK3 3 9 -1.36257783450257 NA -1.78500442116169 -1.40213978179781 -0.382864639363883 2.14207541821896 1.46056679689273 0.236340622757038 0.178735368562428 0.262134289358353 0.730317975302942 NA NA NA 0.794316390087258 99.5502766024175 a8486 loss_cnaBRCA20 226 GSK1070916 AURKB 3 46 0.940007258491471 2.32630161961136 2.02380847702736 2.42873939826459 -0.404930921237228 1.28730930837423 1.98441851565274 0.206617213443047 0.31455604228375 0.204055202087263 0.730331932336822 NA NA NA 0.651112668739305 99.5502766024175 a8487 loss_cnaBRCA36_(FAT1,IRF2) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 9 33 -1.38629436111989 0.693147180559945 -0.127103270846711 -0.350001868258518 0.222898597411807 1.20237268203873 1.81255161955752 0.130499320798425 0.185382286824632 0.122975034204113 0.730391098014106 NA NA NA 0.667012717893077 99.5502766024175 a8488 gain_cnaBRCA19 1230 IOX2 EGLN1 4 43 -2.30258509299405 NA 0.358529549818264 0.239316959982865 0.119212589835399 0.676815600107385 0.656645896884025 0.181171456278885 0.176137473510486 0.181547757171859 0.730521381822232 NA NA NA 0.754548213354884 99.5502766024175 a8489 gain_cnaBRCA12_(TERT) 203 BMS-345541 IKBKB 9 40 2.77258872223978 NA 3.63813348171003 3.50852684477607 0.129606636933958 1.2146230584102 0.96821585246841 0.127767636491138 0.106705233394464 0.133861304381181 0.730649968248265 NA NA NA 0.770509571597122 99.5502766024175 a8490 loss_cnaBRCA22_(SYNCRIP,ZNF292) 204 Tipifarnib Farnesyl-transferase (FNTA) 18 30 2.77258872223978 NA 1.71814649995642 1.56107454402827 0.157071955928153 1.7394820209184 1.38138884713112 0.103095079316275 0.0902981198076557 0.113705823131814 0.731075986948299 NA NA NA 0.746471722813519 99.5502766024175 a8491 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 266 Zibotentan, ZD4054 Endothelin A Receptor 15 34 2.99573227355399 NA 5.70520161372287 5.7582913422001 -0.053089728477234 0.456219366265078 0.511228589150216 0.107147660306008 0.116368862005712 0.103847338752087 0.731128419715487 NA NA NA 0.720235140901231 99.5502766024175 a8492 loss_cnaBRCA38 293 MP470 PDGFR 4 44 2.99573227355399 NA 3.25394094053745 3.55682556046539 -0.302884619927938 1.63797098193743 1.68300959535489 0.18027675727183 0.184914521238758 0.179966068383627 0.73151480614466 NA NA NA 0.743584771758132 99.5502766024175 a8493 gain_cnaBRCA19 258 STF-62247 stimulates autophagy 4 45 2.32630161961136 NA 4.47113162661479 4.64503946349477 -0.173907836879978 1.40234627569264 0.930189282024734 0.179798395345439 0.124012050300545 0.186959622348512 0.731927172234353 NA NA NA 0.822370026110343 99.5502766024175 a8494 loss_cnaBRCA7_(FAS,PTEN) 1036 PLX4720 BRAF 4 39 2.30258509299405 NA 4.79539247078552 4.576228316022 0.219164154763519 0.33460751673973 1.25413676850081 0.181012201769538 0.654988736950561 0.174752993667116 0.732025841000264 NA NA NA 0.414620632606388 99.5502766024175 a8495 MLL3_mut 1371 PLX4720 (rescreen) BRAF 3 44 2.30258509299405 NA 4.52194097354032 4.7197750508399 -0.197834077299576 1.06234214311216 0.957656901069799 0.205530928544887 0.186224446222207 0.206581372805412 0.732118982563725 NA NA NA 0.780545727646692 99.5502766024175 a8496 gain_cnaBRCA58_(CCND1) 238 CAL-101 PI3Kdelta 10 39 2.99573227355399 2.32630161961136 4.81137147039254 4.69527005251907 0.116101417873469 0.67845180503535 1.0051179496094 0.122046499436357 0.171126993858347 0.11551024227414 0.732143108183724 NA NA NA 0.669631410245905 99.5502766024175 a8497 POLR2B_mut 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 39 1.38629436111989 0.693147180559945 3.63507376403144 3.41791871496398 0.217155049067458 0.696396364296069 1.06718555967881 0.206469179494627 0.311826798933626 0.203483871289277 0.732195527080222 NA NA NA 0.65573273758025 99.5502766024175 a8498 gain_cnaBRCA27_(CLTC,PPM1D) 184 BMS-754807 IGF1R 9 39 0.940007258491471 NA 1.45213653382572 1.66719182103083 -0.215055287205111 2.4625688883329 1.4755511832788 0.127315180210061 0.0873296532836078 0.145745731928621 0.732203907211042 NA NA NA 0.806658583807816 99.5502766024175 a8499 loss_cnaBRCA17 1219 PFI-1 BRD2, BRD3, BRD4 9 38 2.30258509299405 NA 3.06886270903645 3.19702225140026 -0.128159542363816 0.867080557902337 1.03161991044709 0.127605665145953 0.147805807886943 0.124231357950694 0.732285461485953 NA NA NA 0.706971072878045 99.5502766024175 a8500 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 133 Doxorubicin DNA intercalating 15 33 0.0237165266173161 NA -1.16663363453072 -0.968831960353592 -0.197801674177124 1.50568716701385 1.97745984991148 0.107112050179521 0.131369701828178 0.100028161980623 0.732436427607548 NA NA NA 0.705552325577111 99.5502766024175 a8501 gain_cnaBRCA31 1072 BMS-708163 g-secretase 14 32 1.6094379124341 NA 3.61053451330302 3.71650019324061 -0.105965679937593 1.27504335246273 0.793484665622475 0.110241922008498 0.0831075113900419 0.133544710475866 0.732456238083262 NA NA NA 0.777054471587552 99.5502766024175 a8502 loss_cnaBRCA17 310 YM201636 FYV1 11 38 1.63315443905142 NA 2.32132578962425 2.44168744790278 -0.120361658278531 1.12299405519013 0.994606114989788 0.117624230242762 0.107179247941925 0.121014396015217 0.732718675757296 NA NA NA 0.752756206602434 99.5502766024175 a8503 loss_cnaBRCA36_(FAT1,IRF2) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 9 40 1.63315443905142 NA 3.47256624450415 3.60007729527367 -0.127511050769522 1.20702647904899 0.959738086203322 0.126734026698336 0.105640640849891 0.132860259067085 0.732742587033749 NA NA NA 0.772664344026646 99.5502766024175 a8504 gain_cnaBRCA61_(NOTCH2) 261 TL-1-85 MAP3K7 (TAK1) 3 46 2.32630161961136 NA 3.79055235884989 4.04008390770963 -0.249531548859735 1.98842372427376 1.17359178247079 0.204633314208689 0.125492140238305 0.212622099597861 0.732818593454657 NA NA NA 0.848966936626175 99.5502766024175 a8505 gain_cnaBRCA10_(MDM2,NUP107) 1052 RO-3306 CDK1 3 40 1.6094379124341 NA 3.75713600222735 3.50831366253433 0.248822339693016 1.17829596530388 1.21129878362039 0.205687631831396 0.211171341513375 0.205417806950423 0.732896222355665 NA NA NA 0.754142354363314 99.5502766024175 a8506 gain_cnaBRCA19 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 39 1.38629436111989 0.693147180559945 3.23233617572814 3.44889852944885 -0.216562353720718 1.21194370145438 1.04265182584207 0.205903983617085 0.178690110325121 0.207703423475826 0.732899527313644 NA NA NA 0.789123136390374 99.5502766024175 a8507 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1010 Gefitinib EGFR 5 40 -0.693147180559945 NA 1.55175609669644 1.38091552942648 0.170840567269967 0.483870040103059 1.0902012291494 0.16290811909463 0.353071182571213 0.156705535365485 0.732940717754566 NA NA NA 0.550349415674782 99.5502766024175 a8508 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 257 NPK76-II-72-1 PLK3 6 43 2.32630161961136 NA 3.26965811945447 3.50816525208436 -0.23850713262989 1.2224968173242 1.63314601360401 0.149581619714307 0.195098366924123 0.14604152393181 0.732953176379088 NA NA NA 0.680580513896299 99.5502766024175 a8509 PIK3CA_mut 1009 ATRA Retinoic acid and retinoid X receptor agonist 16 29 2.30258509299405 NA 4.0256799142432 4.15026933080933 -0.124589416566133 1.05952275795162 1.21798874293165 0.106928996963322 0.117590127848695 0.102291106784986 0.733001689594433 NA NA NA 0.72272070651138 99.5502766024175 a8510 ARID1A_mut 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 5 44 1.63315443905142 NA 3.43034904255584 3.59328279087966 -0.162933748323822 0.433097212412279 1.04356347350071 0.161940420407236 0.376205950198358 0.156132092068391 0.733024922743773 NA NA NA 0.527700672303034 99.5502766024175 a8511 loss_cnaBRCA36_(FAT1,IRF2) 1033 Vismodegib SMO 8 37 2.30258509299405 NA 4.84646835108264 4.74102996829793 0.105438382784713 0.624214500027834 0.815644618479202 0.13386308454061 0.168913703190187 0.129270003621561 0.733029913909412 NA NA NA 0.689808285155941 99.5502766024175 a8512 BRCA1_mut 308 XL-880 MET 4 45 1.63315443905142 NA 2.11301687706961 1.82414807817351 0.288868798896103 1.40803963643412 1.62733707191366 0.178951479592175 0.205156723874384 0.17751011998787 0.733140085078647 NA NA NA 0.719068135876025 99.5502766024175 a8513 gain_cnaBRCA58_(CCND1) 263 FR-180204 ERK 10 39 2.99573227355399 NA 5.42920286061751 5.33959823007542 0.0896046305420946 0.661134822692024 0.754652974328458 0.121470860678041 0.135531554936466 0.118736205368873 0.73335671908315 NA NA NA 0.715578580758723 99.5502766024175 a8514 loss_cnaBRCA34 1008 Methotrexate Dihydrofolate reductase (DHFR) 5 40 -1.6094379124341 NA 0.841218611184829 0.662829007356491 0.178389603828338 0.575125081344563 1.13700164778228 0.162624310272867 0.310175315970028 0.15689476279677 0.733387630646356 NA NA NA 0.584164590925646 99.5502766024175 a8515 gain_cnaBRCA9_(KRAS) 231 FMK RSK 4 45 2.99573227355399 2.32630161961136 5.68723547428298 5.58051807275279 0.106717401530185 0.232939262228355 0.614084134951671 0.17873515444141 0.4581340239052 0.17378302981005 0.733450006211324 NA NA NA 0.492701275575879 99.5502766024175 a8516 loss_cnaBRCA18 211 TL-2-105 CRAF 16 33 2.32630161961136 1.63315443905142 3.83059681212589 3.94486618471061 -0.114269372584716 1.17277007614476 1.05661462471845 0.104353209483579 0.0974354435784656 0.108146688406064 0.733463839558361 NA NA NA 0.743818507465403 99.5502766024175 a8517 gain_cnaBRCA19 1262 UNC1215 LMBL3 4 42 0 NA 2.65963776754119 2.76684245673188 -0.107204689190688 0.681476586543575 0.59132947388329 0.17929970581319 0.157312358645257 0.181294344228556 0.733490666879973 NA NA NA 0.778645944769956 99.5502766024175 a8518 gain_cnaBRCA62 1218 JQ1 BRD2, BRD3, BRD4 8 38 0 NA 2.53577845684996 2.44160364361939 0.0941748132305684 1.04141804620325 0.62346589632981 0.133261701423343 0.0904294039976612 0.151050464484028 0.733544940831807 NA NA NA 0.811334020986563 99.5502766024175 a8519 loss_cnaBRCA36_(FAT1,IRF2) 1043 JNK Inhibitor VIII JNK 9 34 2.30258509299405 NA 4.72106852811029 4.81751835404692 -0.0964498259366309 0.554030213196135 0.791696914376702 0.128385711438409 0.174087664606273 0.121826704367751 0.733734594610797 NA NA NA 0.678972056980712 99.5502766024175 a8520 gain_cnaBRCA63 1261 rTRAIL TR10A (DR4), TR10B (DR5) 6 41 -2.30258509299405 NA -0.00437901720984838 -0.160541443788775 0.156162426578927 1.63535715705181 0.944214409055869 0.149601490134782 0.0954913279374723 0.165388734890284 0.733749631021666 NA NA NA 0.827590170078007 99.5502766024175 a8521 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1091 BMS-536924 IGF1R 6 41 1.38629436111989 NA 3.16701733778597 3.00227073842499 0.164746599360986 0.779730483923733 1.1353575368764 0.149561893698007 0.211286595506634 0.145105479120028 0.733817339144657 NA NA NA 0.662512561159885 99.5502766024175 a8522 loss_cnaBRCA34 1017 Olaparib PARP1, PARP2 5 40 1.6094379124341 NA 3.9448889923607 4.09024923599993 -0.145360243639223 0.799436561493763 0.904699777105765 0.162335684022396 0.181828365927641 0.16067235487141 0.733842225484591 NA NA NA 0.720277585786378 99.5502766024175 a8523 gain_cnaBRCA13_(FGFR1,WHSC1L1) 304 SB52334 ALK5 11 38 2.99573227355399 NA 4.41823827512815 4.26821248991592 0.150025785212232 1.16116634118122 1.31180288074498 0.117094516877351 0.129202664503361 0.114366104400557 0.733875153618747 NA NA NA 0.71847904036471 99.5502766024175 a8524 gain_cnaBRCA10_(MDM2,NUP107) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 4 44 2.07944154167984 NA 3.40545319623744 3.19692620123252 0.208526995004914 0.794359345928541 1.19011406937137 0.178472690423714 0.262509651423769 0.175215973301669 0.734096035011503 NA NA NA 0.655450332941548 99.5502766024175 a8525 CDH1_mut 1017 Olaparib PARP1, PARP2 4 41 1.6094379124341 NA 4.22017554262061 4.05984663978825 0.160328902832366 1.17224361770122 0.871133504926697 0.179051820182182 0.136770975257492 0.18404630510206 0.734153136607015 NA NA NA 0.805542903379108 99.5502766024175 a8526 loss_cnaBRCA38 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 3 40 1.6094379124341 NA 3.14116634528949 2.84746840079777 0.293697944491722 0.857573883470376 1.46087890538395 0.204334853198618 0.342475383349133 0.201041950437727 0.734584024962783 NA NA NA 0.628682421550367 99.5502766024175 a8527 gain_cnaBRCA14_(RAD21) 211 TL-2-105 CRAF 21 28 2.32630161961136 1.63315443905142 3.84598016617993 3.95373391427449 -0.107753748094567 1.06308333590863 1.11812002842245 0.0984018066779981 0.101359643646815 0.0963704659209049 0.734717654190551 NA NA NA 0.732927217304192 99.5502766024175 a8528 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1230 IOX2 EGLN1 6 41 -2.30258509299405 NA 0.334996679445873 0.236945546386854 0.0980511330590185 0.645278628736666 0.659615890045123 0.14900520980658 0.15195162011019 0.148648834175767 0.734769469805077 NA NA NA 0.73960488873083 99.5502766024175 a8529 gain_cnaBRCA15 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 22 27 3.68887945411394 NA 3.3945982383271 3.51230781414996 -0.117709575822864 1.121834608365 1.26405435860635 0.0978800753163285 0.104925962298862 0.0931206597417552 0.734778832798749 NA NA NA 0.7316188189972 99.5502766024175 a8530 TP53_mut 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 34 9 0.693147180559945 NA 2.9341647895897 2.81115566390443 0.123009125685268 1.04651596539718 0.480395164501866 0.127793216051057 0.117541566256547 0.256058209521778 0.734915374276926 NA NA NA 0.612874849797235 99.5502766024175 a8531 ARID1A_mut 1149 TW 37 BCL2, BCL2L1 5 38 1.6094379124341 NA -0.322330671884057 -0.118707080521585 -0.203623591362472 1.27080175023099 1.25424308253395 0.16213771132699 0.160232381900214 0.162347789035512 0.734978526841588 NA NA NA 0.749359233052493 99.5502766024175 a8532 PIK3CA_mut 275 I-BET BRD2, BRD3, BRD4 17 32 2.99573227355399 NA 4.13022181239878 3.99044815926494 0.139773653133843 1.45325787483044 1.32135574124445 0.102197069399425 0.0961795257088499 0.105780486488978 0.734983977342553 NA NA NA 0.743265210902377 99.5502766024175 a8533 ARID1A_mut 258 STF-62247 stimulates autophagy 5 44 2.32630161961136 NA 4.49129194299447 4.6467009692898 -0.155409026295334 1.44545366602514 0.910100112328745 0.160668133350667 0.107515743982783 0.170760363821599 0.735040751597494 NA NA NA 0.824694149292788 99.5502766024175 a8534 gain_cnaBRCA14_(RAD21) 166 FTI-277 Farnesyl transferase (FNTA) 21 26 0.0237165266173161 NA 2.28972554429045 2.20776906261348 0.0819564816769742 1.01496693829951 0.622192874917443 0.0999085401462279 0.0807479323555949 0.131721986832216 0.735045247289938 NA NA NA 0.747993009530974 99.5502766024175 a8535 loss_cnaBRCA42 155 AP-24534 ABL 3 44 -0.669430653942629 NA 1.22817427649726 1.46016786212422 -0.231993585626954 0.966398845005889 1.14959000529158 0.203133885389909 0.240059874684081 0.201805499838277 0.735121229645505 NA NA NA 0.723857854512312 99.5502766024175 a8536 gain_cnaBRCA12_(TERT) 229 LY317615 PRKCB (PKCbeta) 9 40 2.99573227355399 2.32630161961136 3.52502476577235 3.32113369090813 0.203891074864219 1.52939585668467 1.64257773220513 0.125558748065651 0.133314781763697 0.124128722109546 0.735124517888446 NA NA NA 0.727501700048695 99.5502766024175 a8537 ARID1A_mut 1072 BMS-708163 g-secretase 5 41 1.6094379124341 NA 3.54608594736313 3.7010990154421 -0.155013068078976 0.737819363589736 0.980783868756423 0.161264109771152 0.210096231853804 0.158050181102105 0.735148131386424 NA NA NA 0.685174578793178 99.5502766024175 a8538 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 119 Lapatinib ERBB2, EGFR 4 9 0.693147180559945 NA 1.7757997692815 1.29397928927331 0.481820480008183 2.08964840031438 2.38841593703881 0.208510970237498 0.230574904340699 0.201732232872952 0.735151224744655 NA NA NA 0.725154004170193 99.5502766024175 a8539 loss_cnaBRCA24 1494 SN-38 TOP1 3 45 -2.99573227355399 NA -2.9815956905173 -3.32526803121734 0.343672340700037 1.7856761600057 1.68987902640682 0.202857461861425 0.192460619902626 0.203370972317934 0.735252874511861 NA NA NA 0.77378248292622 99.5502766024175 a8540 loss_cnaBRCA36_(FAT1,IRF2) 1047 Nutlin-3a MDM2 9 34 2.07944154167984 1.38629436111989 4.10480222536184 4.23398224700771 -0.129180021645866 1.18862721211729 0.964674476747462 0.127614103662271 0.108680013656897 0.133910479399657 0.735272454115236 NA NA NA 0.769152304570551 99.5502766024175 a8541 PTEN_mut 1058 GDC0941 PI3K (class 1) 6 37 1.38629436111989 0.693147180559945 1.52594962631444 1.31682196574506 0.209127660569373 1.8904381528154 1.31312430449301 0.149765593405642 0.110623910260128 0.159259606919023 0.73537252940102 NA NA NA 0.803131911468748 99.5502766024175 a8542 gain_cnaBRCA48 1192 GSK269962A ROCK1, ROCK2 5 41 1.6094379124341 NA 2.87948095303068 2.64214640458475 0.237334548445925 1.12635680076949 1.50363203698103 0.161086964738294 0.210709917393658 0.157840843111086 0.735427786697161 NA NA NA 0.6844962603536 99.5502766024175 a8543 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 94 TGX221 PI3Kbeta 3 11 2.30258509299405 NA 4.00091039605739 3.70596607976328 0.294944316294111 1.94750832506231 1.14056703846843 0.225141177405337 0.151447011804006 0.258594459024668 0.735583064881364 NA NA NA 0.821915312252934 99.5502766024175 a8544 gain_cnaBRCA63 6 PHA-665752 MET 3 11 0.693147180559945 NA 3.00216909798416 2.8268175725882 0.175351525395964 0.871026306462401 0.759452937605007 0.225052357173928 0.201315992519376 0.230891891667374 0.735682984468052 NA NA NA 0.772519098241268 99.5502766024175 a8545 gain_cnaBRCA27_(CLTC,PPM1D) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 9 40 3.68887945411394 NA 3.33648479808974 3.48712772606094 -0.150642927971205 1.30446122628456 1.18062047783178 0.125264294571388 0.115482871346261 0.127596404432915 0.735721698404022 NA NA NA 0.756105543449843 99.5502766024175 a8546 BRCA1_mut 1007 Docetaxel Microtubules 4 41 -4.38202663467388 NA -4.33549654344909 -4.61184386158355 0.276347318134463 0.364224842177529 1.60797993396293 0.177846316505053 0.758727264407096 0.171859929528719 0.735873607458606 NA NA NA 0.383671785794149 99.5502766024175 a8547 loss_cnaBRCA23 1230 IOX2 EGLN1 3 44 -2.30258509299405 NA 0.374162376405485 0.240960462484541 0.133201913920944 0.619342773683398 0.659791475330043 0.202420198634555 0.215069779742091 0.201884866509246 0.736015918819332 NA NA NA 0.749751898132974 99.5502766024175 a8548 gain_cnaBRCA30_(CRNKL1,FOXA2) 1259 BMN-673 PARP1 5 41 2.30258509299405 NA 3.53000093326899 3.27816451698777 0.251836416281225 0.805625907813282 1.62389911854743 0.160685277040744 0.312597216448496 0.155081318417422 0.736062057358073 NA NA NA 0.582017834263064 99.5502766024175 a8549 loss_cnaBRCA36_(FAT1,IRF2) 1020 Lenalidomide TNFA 8 37 1.6094379124341 NA 4.17697858426914 4.27153695366577 -0.0945583693966263 0.462627103710946 0.754446841536155 0.132230421350448 0.204394357006172 0.125334701122339 0.736159698321906 NA NA NA 0.651130330990321 99.5502766024175 a8550 ASH1L_mut 283 GSK2126458 PI3K, MTOR 3 45 -2.05572501506252 0.0237165266173161 -2.7440270086396 -3.07611329703158 0.332086288391982 0.551986039183262 1.67723149269663 0.201950102132292 0.601620810706278 0.197996692667664 0.736391481691978 NA NA NA 0.448700096383395 99.5502766024175 a8551 gain_cnaBRCA10_(MDM2,NUP107) 287 KIN001-244 PDPK1 (PDK1) 5 44 2.99573227355399 NA 3.614239919394 3.46263628304618 0.151603636347815 0.714114915578847 0.967540748017868 0.159816260802488 0.212295854687377 0.156689665689424 0.736391524795489 NA NA NA 0.681423638631789 99.5502766024175 a8552 loss_cnaBRCA60 1494 SN-38 TOP1 3 45 -2.99573227355399 NA -3.62436632843441 -3.2824166553562 -0.341949673078213 1.44444636607975 1.70466045259024 0.20183809379741 0.236734074111918 0.200596941495662 0.736532077722745 NA NA NA 0.727192936506695 99.5502766024175 a8553 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1218 JQ1 BRD2, BRD3, BRD4 9 37 0 NA 2.52949531925397 2.44058670916354 0.0889086100904346 0.929974317906748 0.646715873058573 0.125805806950121 0.0956032961109683 0.137477080421655 0.736605073827598 NA NA NA 0.791701418342096 99.5502766024175 a8554 gain_cnaBRCA58_(CCND1) 1007 Docetaxel Microtubules 9 36 -4.38202663467388 NA -4.74409987676355 -4.54807460021805 -0.196025276545493 0.981430809618413 1.65717451673024 0.126153191151641 0.19973417853237 0.118288855257242 0.73663037713424 NA NA NA 0.651756824989197 99.5502766024175 a8555 gain_cnaBRCA58_(CCND1) 224 AS605240 PI3Kgamma 10 39 2.99573227355399 2.32630161961136 3.11845282681845 3.30918083201756 -0.190728005199104 1.61365840567691 1.58494732803959 0.119918117674983 0.118196022484136 0.120337125294261 0.736633768909128 NA NA NA 0.742911420280536 99.5502766024175 a8556 gain_cnaBRCA64_(SDHC) 165 DMOG Prolyl-4-Hydroxylase 8 38 8.29404964010203 NA 7.73791740168177 7.53462545708044 0.203291944601332 1.87229272818589 1.47523136707496 0.131560105022373 0.108579145526195 0.137803431474219 0.736816000071367 NA NA NA 0.779323096736782 99.5502766024175 a8557 loss_cnaBRCA60 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 46 3.68887945411394 NA 3.23213775419373 3.4742838904927 -0.242146136298968 1.20363224128177 1.20256953595393 0.201349709826547 0.20117950316876 0.201357284597175 0.736940688388152 NA NA NA 0.764364812707584 99.5502766024175 a8558 gain_cnaBRCA31 64 CMK RSK 3 9 1.38629436111989 NA 2.41807090442278 2.13285166643643 0.285219237986348 1.79215878483107 1.05603337835986 0.230245349043847 0.159148419437194 0.270085438425559 0.736972405085742 NA NA NA 0.814232532268903 99.5502766024175 a8559 loss_cnaBRCA42 326 GSK690693 AKT 3 45 2.32630161961136 NA 2.57297927842671 2.96401818198155 -0.391038903554844 2.83974421491331 1.89109116614393 0.201359157234926 0.137702156941195 0.206779509394146 0.737133355165736 NA NA NA 0.834934704013415 99.5502766024175 a8560 POLR2B_mut 260 NG-25 MAP3K7 (TAK1) 3 46 2.32630161961136 NA 2.96425065067807 3.22426249732732 -0.260011846649254 0.40529005850949 1.3188587536618 0.201061090099069 0.641545088980182 0.197149123003 0.737303384970799 NA NA NA 0.427821939398529 99.5502766024175 a8561 loss_cnaBRCA36_(FAT1,IRF2) 127 GSK269962A ROCK1, ROCK2 3 11 0.916290731874155 NA 2.66717238295901 2.41377548618421 0.253396896774797 0.529688813366153 1.21935399554861 0.223469186127059 0.47838823547069 0.207812413540163 0.737464840981994 NA NA NA 0.609855641610347 99.5502766024175 a8562 loss_cnaBRCA33 1495 AZD-2281 PARP1, PARP2 4 41 2.30258509299405 NA 4.18179937963104 3.98082709376745 0.200972285863599 1.22810947995063 1.13046422173536 0.176671368731749 0.16364362391509 0.177778546193253 0.737551790278192 NA NA NA 0.770877459432462 99.5502766024175 a8563 gain_cnaBRCA27_(CLTC,PPM1D) 111 Salubrinal GADD34-PP1C 3 10 2.77258872223978 NA 3.03817828004317 3.29655335579978 -0.258375075756616 1.08598905029596 1.15413005000254 0.226239314134035 0.237916833218717 0.223869983938159 0.737564660066962 NA NA NA 0.742167819321174 99.5502766024175 a8564 gain_cnaBRCA63 299 OSI-027 MTORC1/2 7 41 2.99573227355399 NA 1.03375103695762 1.3091288242819 -0.27537778732428 1.35708875499634 2.07658697821084 0.137861824485606 0.202918037829459 0.132610764785562 0.737571561434989 NA NA NA 0.658447013025611 99.5502766024175 a8565 loss_cnaBRCA29_(MAP2K4) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 7 39 1.63315443905142 NA 1.74856186684517 1.97034450584414 -0.221782638998973 1.94662953772949 1.54143900430125 0.138377559972347 0.113931610869141 0.143880256293053 0.737638866216736 NA NA NA 0.782868281833754 99.5502766024175 a8566 loss_cnaBRCA28_(GPS2) 1133 JNJ-26854165 MDM2 4 39 2.30258509299405 NA 2.82772481816266 2.98328664881532 -0.155561830652661 0.660469090690914 0.893496695874074 0.177067725470708 0.235532340339998 0.174104539357564 0.737639894401053 NA NA NA 0.686742076406306 99.5502766024175 a8567 gain_cnaBRCA9_(KRAS) 301 PHA-793887 CDK-pan 4 44 2.32630161961136 NA 3.18881510247323 2.89803852466236 0.290776577810871 1.57321133393368 1.65752414273991 0.175998189740179 0.184829953572613 0.175428260930313 0.737641558352714 NA NA NA 0.74407768202419 99.5502766024175 a8568 ASH1L_mut 265 Tubastatin A HDAC6 3 46 2.99573227355399 NA 4.49550693119347 4.70455857345531 -0.209051642261836 1.05370090883294 1.04092255591362 0.200727568453436 0.19839751537595 0.200833040915662 0.737722583170016 NA NA NA 0.767375525484445 99.5502766024175 a8569 gain_cnaBRCA13_(FGFR1,WHSC1L1) 308 XL-880 MET 11 38 1.63315443905142 NA 1.99209887450028 1.80593798438377 0.186160890116509 1.71638775712075 1.58558282071051 0.11531977426507 0.108460858768181 0.117408493384842 0.737754327474017 NA NA NA 0.751714593793036 99.5502766024175 a8570 loss_cnaBRCA20 1241 CHIR-99021 GSK3B 3 43 2.30258509299405 NA 4.41654258333601 4.21857624428817 0.197966339047839 0.629792131155589 0.997887130949464 0.20115527976077 0.314335999537809 0.198385501634317 0.737825164721946 NA NA NA 0.652832082504219 99.5502766024175 a8571 gain_cnaBRCA31 282 EKB-569 EGFR 15 32 0.916290731874155 2.99573227355399 1.73076236512163 1.50649171156342 0.224270653558213 2.66664660703712 1.83624593853983 0.105312194380129 0.0841021277309021 0.1221354116304 0.738020191070013 NA NA NA 0.771249033713418 99.5502766024175 a8572 ARID1A_mut 1026 17-AAG HSP90 4 39 0 NA -0.607786920919729 -0.925788160923914 0.318001240004186 3.47590753911376 1.59329426018997 0.176752472145788 0.091487255177468 0.199587262660615 0.738089216596669 NA NA NA 0.867431437380699 99.5502766024175 a8573 TP53_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 36 10 1.38629436111989 NA 2.89759539647256 2.71825909495627 0.17933630151629 1.23712591964702 2.21778174118529 0.120267985915326 0.144962043611097 0.0808629172952085 0.738129882076386 NA NA NA 0.810885816515353 99.5502766024175 a8574 gain_cnaBRCA14_(RAD21) 1166 QL-VIII-58 MTOR, ATR 13 13 2.30258509299405 NA -1.4437490512073 -1.59430509580368 0.150556044596386 1.41690414359079 0.755880332992245 0.132583611444649 0.106257043059271 0.199179735237179 0.738284709712641 NA NA NA 0.739188733349887 99.5502766024175 a8575 ARID1A_mut 173 FH535 unknown 5 43 3.46573590279973 NA 1.38972756041805 1.5943085945902 -0.204581034172156 0.957402863171413 1.31545750169312 0.158801820886817 0.213683332316845 0.155520823674532 0.738332162816989 NA NA NA 0.680563835287574 99.5502766024175 a8576 loss_cnaBRCA36_(FAT1,IRF2) 282 EKB-569 EGFR 9 38 0.916290731874155 2.99573227355399 1.79248722543868 1.52728382152384 0.265203403914841 1.84382312116566 2.1864710110784 0.124532668792682 0.143833430045708 0.12129289735428 0.738485784737802 NA NA NA 0.714250495108735 99.5502766024175 a8577 BRCA2_mut 1011 ABT-263 BCL2, BCL2L1, BCL2L2 5 38 0.693147180559945 NA 1.91970892477843 1.65066256071092 0.269046364067507 2.00510165325518 1.64445376940171 0.159856963415643 0.134180909796131 0.163608347691886 0.738564198696589 NA NA NA 0.785824500619184 99.5502766024175 a8578 gain_cnaBRCA48 346 THZ-2-102-1 CDK7 5 43 0.916290731874155 2.99573227355399 -0.9713313631598 -1.3774630195531 0.4061316563933 3.22755418202045 2.48793552770146 0.158599047134517 0.125832637808441 0.163240426398233 0.738653670748131 NA NA NA 0.797386386323821 99.5502766024175 a8579 gain_cnaBRCA47_(EGFR) 1264 SGC0946 Q8TEK3 (DOT1L) 6 40 -0.693147180559945 NA 1.87261998328002 1.96242771532728 -0.0898077320472548 0.362364888739154 0.635869009381227 0.146988124341107 0.247837842015379 0.141236214884333 0.738659264732263 NA NA NA 0.626058696398768 99.5502766024175 a8580 gain_cnaBRCA31 104 Bortezomib Proteasome 4 10 -3.91202300542815 NA -4.31071078756757 -4.67631596413947 0.365605176571902 1.0901888210075 1.99330944927027 0.201961302396722 0.335359498764653 0.183416165867145 0.738723107063531 NA NA NA 0.669950488853722 99.5502766024175 a8581 loss_cnaBRCA18 1032 Afatinib ERBB2, EGFR 14 31 -0.693147180559945 NA 0.427795888025974 0.228454322432827 0.199341565593147 1.39629159442003 2.00757711583971 0.108087381472252 0.142764997218182 0.0992945994554078 0.738751446476641 NA NA NA 0.703171603332297 99.5502766024175 a8582 gain_cnaBRCA47_(EGFR) 1028 VX-702 p38 7 38 0.693147180559945 NA 3.34658301076608 3.4416140356804 -0.0950310249143196 0.47755809536846 0.716801043199748 0.138040666939621 0.198993642524264 0.132576571722201 0.738793114354507 NA NA NA 0.66613743017254 99.5502766024175 a8583 gain_cnaBRCA61_(NOTCH2) 206 Ruxolitinib JAK1, JAK2, TYK2 3 46 1.65632149833295 0.0237165266173161 4.49361887758751 4.36221533764026 0.131403539947252 0.350184126180717 0.667871203146436 0.19985721950058 0.375241280581175 0.196749821414954 0.738816890298975 NA NA NA 0.599376311321959 99.5502766024175 a8584 ARID1A_mut 1261 rTRAIL TR10A (DR4), TR10B (DR5) 5 42 -2.30258509299405 NA 0.00742587240484967 -0.158228634776741 0.165654507181591 0.878024744566731 1.05870283977412 0.158686635030643 0.188667242246498 0.156469314106056 0.738860028451759 NA NA NA 0.711560343125994 99.5502766024175 a8585 loss_cnaBRCA57 268 YM155 BIRC5 (Survivin) 5 44 1.63315443905142 NA -3.36713320415496 -3.62153763809293 0.254404433937963 1.38297671268872 1.62759215193695 0.158189775757924 0.183954242760431 0.15630723804806 0.738972897340025 NA NA NA 0.716938186061631 99.5502766024175 a8586 gain_cnaBRCA48 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 5 43 2.07944154167984 NA 3.04859091810269 3.23357234996901 -0.184981431866318 1.42649768596109 1.14083911221494 0.158312893043583 0.129675241458025 0.16214506487876 0.73910746268215 NA NA NA 0.791772725997337 99.5502766024175 a8587 gain_cnaBRCA58_(CCND1) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 8 35 0.693147180559945 NA 1.50195746099104 1.72308749265654 -0.221130031665499 1.94129602576077 1.62480042422191 0.131386116116152 0.113908455346907 0.136096734324398 0.739131134841633 NA NA NA 0.77137370672808 99.5502766024175 a8588 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 274 PXD101, Belinostat HDAC 9 39 2.99573227355399 NA 0.520056491279385 0.706452620124286 -0.186396128844901 0.587683427175559 1.63402475805293 0.123831504742826 0.317170980540887 0.114071789871169 0.739252427277522 NA NA NA 0.571933869880061 99.5502766024175 a8589 gain_cnaBRCA9_(KRAS) 326 GSK690693 AKT 4 44 2.32630161961136 NA 3.25086934938907 2.91127905970213 0.339590289686943 2.03541655175023 1.93535457708392 0.174862888345008 0.166840683984285 0.175466704503636 0.739270182138616 NA NA NA 0.766555150957933 99.5502766024175 a8590 loss_cnaBRCA20 230 GSK429286A ROCK2 3 46 2.99573227355399 2.32630161961136 5.57447532486593 5.3944836900035 0.179991634862439 0.607468995943357 0.913521566254737 0.199411406052555 0.296297648216474 0.197030526165212 0.739377632176806 NA NA NA 0.668832604162118 99.5502766024175 a8591 gain_cnaBRCA58_(CCND1) 1091 BMS-536924 IGF1R 9 38 1.38629436111989 NA 2.91278415297003 3.04947755066869 -0.136693397698656 1.13124277525167 1.0950722735569 0.12408743129114 0.120834714430106 0.124825914233645 0.739385602839134 NA NA NA 0.748696736642393 99.5502766024175 a8592 gain_cnaBRCA19 1067 CCT007093 PPM1D 4 42 1.88706964903238 NA 4.2443186990683 4.07052360722416 0.173795091844139 1.25202896553054 0.970463302847649 0.175160920645068 0.138810759677987 0.179084661248054 0.739408692380549 NA NA NA 0.802940406305004 99.5502766024175 a8593 gain_cnaBRCA14_(RAD21) 29 AZ628 BRAF 6 8 1.38629436111989 NA 2.70718251808282 2.32026636075219 0.386916157330635 1.18417715746374 2.56778799839375 0.183818826171889 0.32673840640477 0.150680725033634 0.739464880291032 NA NA NA 0.714369476937243 99.5502766024175 a8594 loss_cnaBRCA33 176 IPA-3 PAK1, PAK2, PAK3 6 41 3.46573590279973 NA 4.69057785502712 4.46848748829291 0.222090366734215 0.953511953000417 1.57575684540274 0.14618359071711 0.232918282812673 0.140942028830249 0.739601913020822 NA NA NA 0.640433893228858 99.5502766024175 a8595 loss_cnaBRCA60 1262 UNC1215 LMBL3 3 43 0 NA 2.86915613273515 2.74973176406275 0.119424368672408 0.252576435113628 0.60952970695933 0.199724548483215 0.472824666397251 0.195928709148833 0.739619720767443 NA NA NA 0.528492326922619 99.5502766024175 a8596 loss_cnaBRCA20 1375 Temozolomide DNA akylating agent 3 43 3.40119738166216 NA 6.03120622597859 5.8909807988657 0.14022542711289 0.327350774751561 0.715675826218457 0.19955355106411 0.428364427178498 0.195934279146781 0.739834299978485 NA NA NA 0.559788920041349 99.5502766024175 a8597 loss_cnaBRCA24 271 VNLG/124 HDAC, RAR 3 46 1.63315443905142 NA 4.30429769040319 4.14147113271074 0.162826557692457 0.719901946572189 0.822364941955346 0.198989708246275 0.226178799026389 0.197997931800574 0.739908173188482 NA NA NA 0.738103679050257 99.5502766024175 a8598 CDH1_mut 1377 Afatinib (rescreen) ERBB2, EGFR 5 42 2.30258509299405 NA 3.117167088898 2.80100596822945 0.316161120668547 2.1104977313469 1.99004403234726 0.15799803319315 0.149804056158248 0.158871419691973 0.739950767212209 NA NA NA 0.763240845981906 99.5502766024175 a8599 gain_cnaBRCA14_(RAD21) 288 KIN001-055 JAK3, MNK1 21 28 2.32630161961136 NA 4.29161579955738 4.3745503821761 -0.0829345826187273 0.688072369894168 0.968754789911247 0.0963707242372984 0.120531772888197 0.0856094684459061 0.739986784151196 NA NA NA 0.727706125264401 99.5502766024175 a8600 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 17 Cyclopamine SMO 3 10 2.77258872223978 NA 4.54990395318341 4.73936122477266 -0.189457271589245 1.72748333336124 0.45995042125924 0.223951722839147 0.109672416474554 0.411908029284013 0.740108549151439 NA NA NA 0.867608961650882 99.5502766024175 a8601 BRCA1_mut 1268 XAV 939 TNKS1 (tankyrase-1) 4 43 1.6094379124341 NA 3.51063431803285 3.67547137113831 -0.164837053105463 0.632606224250345 0.963845340108102 0.174360564270489 0.260568180941943 0.171020231406603 0.740266943547599 NA NA NA 0.658895760295392 99.5502766024175 a8602 gain_cnaBRCA15 225 Genentech Cpd 10 AURKA, AURKB 22 27 2.32630161961136 NA 2.93237593318937 3.08788290249349 -0.155506969304123 1.58376396310381 1.65544403880503 0.0957668531059502 0.0981882230729415 0.093936711636821 0.740289411660558 NA NA NA 0.739175119638916 99.5502766024175 a8603 loss_cnaBRCA38 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 3 42 2.30258509299405 NA 1.15881739890917 1.38007448793235 -0.221257089023172 1.24491286443217 1.10278268669538 0.19936715566632 0.177728976336101 0.200635258145189 0.740299007026495 NA NA NA 0.790164150797466 99.5502766024175 a8604 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1377 Afatinib (rescreen) ERBB2, EGFR 8 39 2.30258509299405 NA 3.04953551688732 2.79055902500073 0.258976491886591 1.49478509578028 2.08092089917956 0.129420143803588 0.173253327597172 0.124452828547542 0.74034369005429 NA NA NA 0.685109194890662 99.5502766024175 a8605 BRCA1_mut 155 AP-24534 ABL 4 43 -0.669430653942629 NA 1.62739134024886 1.4284265907433 0.198964749505564 1.42406565902413 1.1192813239558 0.174204466251341 0.13971599430458 0.177761162673899 0.74049081396996 NA NA NA 0.801710627426309 99.5502766024175 a8606 loss_cnaBRCA22_(SYNCRIP,ZNF292) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 17 30 0.940007258491471 NA 1.97000380535418 1.84256314308839 0.127440662265788 1.43511859655337 1.15457814434712 0.101023600316643 0.0888014848193415 0.110378550719798 0.740844735478242 NA NA NA 0.756478276659553 99.5502766024175 a8607 gain_cnaBRCA12_(TERT) 230 GSK429286A ROCK2 9 40 2.99573227355399 2.32630161961136 5.49593983240662 5.38515543057748 0.110784401829141 0.692164335618868 0.939992497679128 0.122735507415406 0.160055056477431 0.117856687263645 0.740857079633602 NA NA NA 0.691985968891957 99.5502766024175 a8608 gain_cnaBRCA15 1058 GDC0941 PI3K (class 1) 20 23 1.38629436111989 0.693147180559945 1.42203793758026 1.27988485821081 0.142153079369449 1.34039061978743 1.44311441622795 0.101796001718841 0.106053472227366 0.0985043720518099 0.740870690571361 NA NA NA 0.739561708025772 99.5502766024175 a8609 gain_cnaBRCA58_(CCND1) 173 FH535 unknown 9 39 3.46573590279973 NA 1.44421519119654 1.60271719612051 -0.158502004923973 1.10366361400546 1.32390615888198 0.12303089456445 0.143614415581512 0.119722990833297 0.740875529932218 NA NA NA 0.714567992062323 99.5502766024175 a8610 loss_cnaBRCA18 1377 Afatinib (rescreen) ERBB2, EGFR 15 32 2.30258509299405 NA 2.97644810146669 2.76816764337895 0.208280458087742 1.56175567307471 2.17051012126203 0.104084827079317 0.133363023217127 0.0959592199305844 0.74095956268708 NA NA NA 0.710395862873079 99.5502766024175 a8611 ASH1L_mut 1022 AZD7762 CHEK1, CHEK2 3 42 0.693147180559945 NA 0.601654578202211 0.926400407576717 -0.324745829374506 1.0488838236483 1.65704856923964 0.198768469741279 0.30961086638266 0.195978461586989 0.741049886935215 NA NA NA 0.65775177298417 99.5502766024175 a8612 loss_cnaBRCA36_(FAT1,IRF2) 1052 RO-3306 CDK1 9 34 1.6094379124341 NA 3.64492981122636 3.494105476677 0.15082433454936 1.22092671380941 1.20711162496897 0.124666792947187 0.123532668131058 0.124946468437198 0.741156702760155 NA NA NA 0.746641259734574 99.5502766024175 a8613 BRCA1_mut 1021 Axitinib PDGFR, KIT, VEGFR 4 41 0.693147180559945 NA 2.27539552247167 2.48059150336933 -0.205195980897666 1.19540700983743 1.17708582919779 0.174134955216721 0.171653653700401 0.174325419444996 0.741178969545555 NA NA NA 0.761029623898496 99.5502766024175 a8614 gain_cnaBRCA48 158 PF-562271 FAK 5 40 0.940007258491471 NA 2.15138050656122 2.35598391792779 -0.204603411366569 1.33348487731083 1.29395641870899 0.15766809743619 0.153435119398716 0.158122335813061 0.741207120576311 NA NA NA 0.758703951217035 99.5502766024175 a8615 gain_cnaBRCA62 106 XMD8-85 MAP2K5 (ERK5) 5 8 2.07944154167984 NA 3.0751667355085 3.31711080955546 -0.241944074046953 1.63424809565577 0.97021320376473 0.193079742564403 0.148046110434578 0.249372069054651 0.741224326407364 NA NA NA 0.774879979562948 99.5502766024175 a8616 loss_cnaBRCA22_(SYNCRIP,ZNF292) 190 Bleomycin DNA damage 18 30 4.15888308335967 NA 1.90757219252811 2.1808953346102 -0.273323142082094 2.41082180587526 2.94705660814787 0.0989927572877823 0.113373432003973 0.0927444492672533 0.741373460412791 NA NA NA 0.728650869774224 99.5502766024175 a8617 gain_cnaBRCA48 279 BIX02189 MAP2K5 (MEK5) 5 44 2.99573227355399 NA 4.89995332941883 5.04183362580961 -0.14188029639078 1.27002898703754 0.863948705091524 0.156665513908049 0.11171421899726 0.164223055784023 0.741394792722907 NA NA NA 0.818497366941656 99.5502766024175 a8618 BRCA2_mut 135 Gemcitabine DNA replication 6 41 0.0237165266173161 NA -0.627315734671589 -0.223698070475639 -0.403617664195949 2.50974820974107 2.81352019320185 0.145112788262957 0.160819982908799 0.14345646609226 0.741438619330923 NA NA NA 0.72803670963516 99.5502766024175 a8619 gain_cnaBRCA14_(RAD21) 329 QL-XI-92 DDR1 21 27 2.32630161961136 NA 4.20158397820938 4.29358596929076 -0.0920019910813741 1.02656951868145 0.891727917804226 0.0965694739459581 0.0896208093140573 0.103172715852519 0.741470313721616 NA NA NA 0.746114803332457 99.5502766024175 a8620 gain_cnaBRCA64_(SDHC) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 8 39 2.77258872223978 NA 5.12115137827018 4.98828611976725 0.132865258502936 1.19086529734485 0.999322675756849 0.128813178923567 0.111570350399136 0.132955312359253 0.741516383032313 NA NA NA 0.77460311583017 99.5502766024175 a8621 gain_cnaBRCA8_(CHD4,WNK1) 300 CX-5461 RNA Pol I 4 45 2.32630161961136 NA 4.18542425813824 3.88809338523132 0.297330872906918 1.39675960065239 1.73845416750177 0.173000080080938 0.212871902056763 0.17103175825118 0.741682644672152 NA NA NA 0.710783589005253 99.5502766024175 a8622 gain_cnaBRCA16 305 TPCA-1 IKK 16 33 2.99573227355399 NA 4.2728042557731 4.13251890378484 0.140285351988259 1.29582022538354 1.43146973808511 0.100952548826966 0.108259887629658 0.0980009204916346 0.741824863077467 NA NA NA 0.733616941743052 99.5502766024175 a8623 gain_cnaBRCA48 1004 Vinblastine Microtubules 5 40 -2.30258509299405 NA -3.63618613956574 -3.43298213266085 -0.203204006904896 0.556305637058197 1.34496201783157 0.157270380647718 0.365274038888875 0.151085312604228 0.741835817927423 NA NA NA 0.546942013151408 99.5502766024175 a8624 gain_cnaBRCA63 91 KIN001-135 IKKE 3 11 1.6094379124341 NA 3.77494756794754 3.68393584899822 0.0910117189493267 0.278245816222749 0.437134377065531 0.219358098890854 0.327091059929784 0.208200781554371 0.742099286948214 NA NA NA 0.679211529568553 99.5502766024175 a8625 gain_cnaBRCA62 306 TG101348 JAK2 10 38 2.32630161961136 NA 3.34512289522174 3.19324841492959 0.151874480292147 1.57625261010259 1.21195526995728 0.11760971602707 0.0963516122471398 0.125313601959501 0.742212575096536 NA NA NA 0.78169157093301 99.5502766024175 a8626 gain_cnaBRCA10_(MDM2,NUP107) 269 NSC-207895 MDM4 5 44 2.99573227355399 NA 4.77151906424332 4.58489959668268 0.186619467560648 1.43198410340489 1.17093074397611 0.156118628070128 0.130322303939629 0.159377032775609 0.742264384546789 NA NA NA 0.7908830645263 99.5502766024175 a8627 loss_cnaBRCA38 1529 MLN4924 NEDD8-activating enzyme 3 34 0 NA 0.683491746261544 0.341484995239864 0.34200675102168 1.76071939921726 1.71072185670909 0.199581656902797 0.194242621040991 0.199919554239868 0.742337202642306 NA NA NA 0.773097677735088 99.5502766024175 a8628 BRCA2_mut 291 KIN001-266 MAP3K8 (COT) 6 43 2.99573227355399 NA 3.62850033460511 3.79958334956968 -0.171083014964571 0.947471370323093 1.21267647715344 0.14409632096464 0.180568004821329 0.141078860015625 0.742380600536657 NA NA NA 0.700983968741289 99.5502766024175 a8629 MLL3_mut 262 VX-11e ERK 3 46 1.63315443905142 NA 3.5293747290902 3.79294915431082 -0.263574425220621 1.19385228743294 1.34505385759093 0.196848991587031 0.220776412622509 0.195958268684273 0.742603389546019 NA NA NA 0.743837149038134 99.5502766024175 a8630 MLL3_mut 294 MPS-1-IN-1 MPS1 3 46 2.99573227355399 NA 4.97444937199292 4.74230476801688 0.232144603976039 2.04361380076552 1.12603591800339 0.19678086975405 0.113595143998871 0.20616092281289 0.742689210359795 NA NA NA 0.862905532957787 99.5502766024175 a8631 loss_cnaBRCA18 193 GW-2580 CSF1R (cFMS) 15 33 2.99573227355399 NA 5.51644740290474 5.43927135144749 0.0771760514572497 0.600935280942493 0.807319173725236 0.102827549778677 0.128426560903877 0.0955954645560244 0.742739798005969 NA NA NA 0.714553772780326 99.5502766024175 a8632 BRCA1_mut 330 XMD13-2 RIPK 4 44 2.32630161961136 NA 3.52756317959126 3.73860834112002 -0.211045161528755 1.17400794107109 1.22777245893436 0.172374910766969 0.179764679731392 0.171892731420227 0.742843477808142 NA NA NA 0.750637309028511 99.5502766024175 a8633 PTEN_mut 1028 VX-702 p38 7 38 0.693147180559945 NA 3.34787692634663 3.4413756828103 -0.0934987564636756 0.708303240261212 0.685184041793789 0.135809226664773 0.132003852515477 0.136457872280415 0.742859808800914 NA NA NA 0.755097630215018 99.5502766024175 a8634 gain_cnaBRCA19 1038 NU-7441 PRKDC (DNAPK) 3 40 0.693147180559945 NA 3.06780299731046 2.87974466705009 0.188058330260374 0.401069164320595 0.971432850913852 0.197628467756563 0.468892517775438 0.193588604794931 0.742970784725188 NA NA NA 0.534751130634879 99.5502766024175 a8635 gain_cnaBRCA13_(FGFR1,WHSC1L1) 172 Embelin XIAP 10 38 3.46573590279973 NA 3.08344656692788 2.96927681476206 0.114169752165824 1.09762934309533 0.941469004992156 0.117218103868671 0.104014850626955 0.12126766952543 0.743039605435608 NA NA NA 0.768232479873941 99.5502766024175 a8636 gain_cnaBRCA63 1026 17-AAG HSP90 5 38 0 NA -0.64667716155144 -0.92903947768301 0.28236231613157 0.895683306756123 1.87095638793032 0.156934908893449 0.315247938642728 0.150918705509712 0.743166719338576 NA NA NA 0.587135829287863 99.5502766024175 a8637 loss_cnaBRCA60 256 JW-7-24-1 LCK 3 45 2.32630161961136 NA 1.62179070753626 1.85195435671324 -0.230163649176974 0.34068692408977 1.19538485740803 0.196508486356652 0.675586977081417 0.19254355427928 0.743232403232164 NA NA NA 0.417004511141199 99.5502766024175 a8638 BRCA2_mut 156 AZD6482 PI3Kbeta 6 41 1.63315443905142 NA 2.23822458877129 2.02624910143734 0.211975487333942 1.01530285863627 1.51879985769761 0.144064908640376 0.208780548120057 0.139567755593078 0.743237482367229 NA NA NA 0.667979451706619 99.5502766024175 a8639 gain_cnaBRCA9_(KRAS) 271 VNLG/124 HDAC, RAR 4 45 1.63315443905142 NA 4.02229401439459 4.162919758185 -0.140625743790417 0.786132211434902 0.820439367120827 0.171852656164229 0.178883070487262 0.171402969464905 0.743333465266706 NA NA NA 0.751604721680756 99.5502766024175 a8640 gain_cnaBRCA19 197 Bryostatin 1 PRKC 4 44 -4.8283137373023 NA -2.96009249609992 -2.79286859827153 -0.167223897828384 1.00077830607493 0.970609988219826 0.171933851777441 0.167093847671659 0.172287427347709 0.743477538024914 NA NA NA 0.766454795706995 99.5502766024175 a8641 NF1_mut 312 AV-951 VEGFR 4 44 -2.05572501506252 NA 0.530580375114779 0.641520891444311 -0.110940516329533 0.590282487514355 0.649428277016863 0.171804730533871 0.18794478690482 0.170827973243075 0.743663194943245 NA NA NA 0.740701028593653 99.5502766024175 a8642 BRCA1_mut 140 Vinorelbine Microtubules 4 43 -2.74887219562247 NA -3.86043881455716 -3.57557323676803 -0.284865577789131 1.21038001726493 1.68441399549413 0.171912722330623 0.235352181732837 0.169118505635287 0.743780160224601 NA NA NA 0.686287247559551 99.5502766024175 a8643 gain_cnaBRCA62 59 WZ-1-84 BMX 4 8 2.32630161961136 NA 3.39189228297513 3.64689940465504 -0.255007121679908 0.6246153075817 1.42568119391309 0.205501264207774 0.408262683582331 0.178866862219026 0.744120129049869 NA NA NA 0.676297782401385 99.5502766024175 a8644 loss_cnaBRCA24 178 BAY 61-3606 SYK 3 45 2.07944154167984 NA 3.39250613326299 3.07596926755351 0.316536865709478 1.25005759167006 1.63154237223825 0.195776362361037 0.253217825977593 0.194010815223409 0.74415440650467 NA NA NA 0.710979928327537 99.5502766024175 a8645 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1114 Cetuximab EGFR 18 27 4.18661983833127 NA 6.33557546531672 6.24725811501065 0.0883173503060748 0.862624437740671 0.897285388542331 0.0999353639812423 0.102382156639788 0.0984272689980489 0.74418730731323 NA NA NA 0.742424618976128 99.5502766024175 a8646 TP53_mut 306 TG101348 JAK2 37 11 2.32630161961136 NA 3.19153571092359 3.33707703776083 -0.145541326837245 1.35393585402437 1.03527488628386 0.112703199065375 0.107494994245588 0.14058230211656 0.744264366812451 NA NA NA 0.707993291107907 99.5502766024175 a8647 loss_cnaBRCA28_(GPS2) 179 5-Fluorouracil DNA antimetabolite 4 45 3.46573590279973 NA 3.7854871337106 4.0642313151067 -0.2787441813961 1.07018754941924 1.65963970745318 0.171176444893297 0.260462926846204 0.16795463505983 0.744306914557301 NA NA NA 0.658815137887359 99.5502766024175 a8648 CDH1_mut 192 LFM-A13 BTK 4 44 2.77258872223978 NA 4.92769690024672 4.7834495082634 0.144247391983321 0.449112321008275 0.862903351001678 0.171287211001251 0.321183332622628 0.16716517767126 0.744407464548725 NA NA NA 0.600935774332825 99.5502766024175 a8649 loss_cnaBRCA17 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 8 37 2.30258509299405 NA 1.24862271224027 1.39055672951254 -0.141934017272269 1.09809645396421 1.11211489242052 0.127886355016659 0.129254599411442 0.127625318426722 0.744509163530523 NA NA NA 0.747434060736788 99.5502766024175 a8650 TP53_mut 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 36 10 2.30258509299405 NA 1.43870507638612 1.32126633532212 0.117438741063997 0.805640411449592 1.5435747328006 0.117225022675115 0.145770668147951 0.076082316306721 0.744513452440327 NA NA NA 0.821058020929293 99.5502766024175 a8651 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 253 XMD14-99 EPHB3, CAMK1 14 34 2.32630161961136 NA 4.87573858658664 4.95672200348499 -0.0809834168983485 0.739558642603146 0.792711279872711 0.104084028601361 0.109502360236503 0.102160041057259 0.744574032935686 NA NA NA 0.73839929414165 99.5502766024175 a8652 loss_cnaBRCA38 208 SB-715992 KIF11 4 45 -2.05572501506252 NA -1.50967453031386 -1.21591926163399 -0.293755268679876 1.58743240354781 1.72736116461178 0.170910173523947 0.185050568467263 0.17006013258721 0.744690345034061 NA NA NA 0.744122327914238 99.5502766024175 a8653 BRCA2_mut 1050 ZM-447439 AURKB 5 34 1.38629436111989 0.693147180559945 2.7061836063306 2.91465062203385 -0.208467015703257 1.29856075879832 1.3309984291176 0.157033767015891 0.160536974716663 0.15662453925018 0.744867429581369 NA NA NA 0.751091411637397 99.5502766024175 a8654 loss_cnaBRCA28_(GPS2) 258 STF-62247 stimulates autophagy 4 45 2.32630161961136 NA 4.78256538783977 4.61735646249699 0.165208925342785 0.481541975452477 0.991853248913776 0.170783793264522 0.343083124140005 0.166565896238897 0.744872355331877 NA NA NA 0.581376108514907 99.5502766024175 a8655 POLR2B_mut 269 NSC-207895 MDM4 3 46 2.99573227355399 NA 4.8227136544444 4.58967470895481 0.233038945489591 0.453447825443816 1.21792985941086 0.194946406037837 0.513926702066554 0.19134020213801 0.745001530950777 NA NA NA 0.501086720445758 99.5502766024175 a8656 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 202 GSK-1904529A IGF1R 6 42 0.0237165266173161 NA 2.08497680732139 2.20463122741426 -0.119654420092866 0.502707044519529 0.870311144834996 0.142751573026057 0.238020177750299 0.137484646500248 0.745087448977304 NA NA NA 0.636190910094391 99.5502766024175 a8657 loss_cnaBRCA7_(FAS,PTEN) 269 NSC-207895 MDM4 4 45 2.99573227355399 NA 4.79113953702584 4.58730265393669 0.203836883089155 0.84737234480381 1.21550884913302 0.170517310860469 0.240551729519033 0.167696749583143 0.745256186091627 NA NA NA 0.68012616390406 99.5502766024175 a8658 ARID1A_mut 305 TPCA-1 IKK 5 44 2.99573227355399 NA 4.37075473904611 4.15645950504633 0.214295233999778 1.24207303839295 1.40260163648806 0.154206758436094 0.172530300051471 0.152784103786123 0.745307071595121 NA NA NA 0.732535305432877 99.5502766024175 a8659 loss_cnaBRCA36_(FAT1,IRF2) 1038 NU-7441 PRKDC (DNAPK) 9 34 0.693147180559945 NA 2.80063540489213 2.9172787361737 -0.116643331281572 0.826318757843948 0.979560119505545 0.122576123298005 0.141160212296185 0.119077256167238 0.74534024575857 NA NA NA 0.722883924555437 99.5502766024175 a8660 gain_cnaBRCA63 330 XMD13-2 RIPK 7 41 2.32630161961136 NA 3.58133593769482 3.7448699552142 -0.163534017519376 1.52082609873162 1.17345756558841 0.13356603100483 0.107529728517786 0.139360827621725 0.745451769467786 NA NA NA 0.793884168015499 99.5502766024175 a8661 loss_cnaBRCA28_(GPS2) 208 SB-715992 KIF11 4 45 -2.05572501506252 NA -1.50882460929102 -1.21599481016935 -0.292829799121675 0.32572368962308 1.77437377838104 0.170370501268887 0.899012900966863 0.165032758424134 0.745467672744024 NA NA NA 0.354211901145826 99.5502766024175 a8662 TP53_mut 257 NPK76-II-72-1 PLK3 38 11 2.32630161961136 NA 3.43893953198299 3.61721384918191 -0.178274317198925 1.59777275303678 1.58320514944579 0.111792851499376 0.111576766383137 0.112603421774703 0.745483767016398 NA NA NA 0.74691618589517 99.5502766024175 a8663 loss_cnaBRCA60 1114 Cetuximab EGFR 3 42 4.18661983833127 NA 6.44362053242897 6.27108252104051 0.172538011388453 1.19020797621738 0.866038058386943 0.195232552238129 0.144964590085171 0.199226823483736 0.745489868026643 NA NA NA 0.826839523819883 99.5502766024175 a8664 NF1_mut 1001 AICAR AAPK1 (AMPK) agonist 4 41 7.60090245954208 NA 7.521759058095 7.75962712375872 -0.237868065663726 1.14455654999907 1.40693642288285 0.171098726334018 0.207825524797284 0.169068098454888 0.745528741978869 NA NA NA 0.718027479937234 99.5502766024175 a8665 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1218 JQ1 BRD2, BRD3, BRD4 8 38 0 NA 2.38382160491907 2.47359455981537 -0.0897729548962971 0.776166028038684 0.692867832473089 0.127017404285321 0.115662051227811 0.129567214249023 0.745572694129942 NA NA NA 0.768621750505362 99.5502766024175 a8666 gain_cnaBRCA19 1003 Camptothecin TOP1 4 41 -2.30258509299405 NA -2.28016718697072 -2.55358527398634 0.273418087015616 0.902134624083879 1.63975957153686 0.170953096966534 0.303079030242601 0.166742790688122 0.745737586532343 NA NA NA 0.619793197717974 99.5502766024175 a8667 gain_cnaBRCA61_(NOTCH2) 274 PXD101, Belinostat HDAC 3 45 2.99573227355399 NA 0.397084716410948 0.689797921269529 -0.292713204858581 0.994452801468436 1.52449386839921 0.19445061366448 0.294346000560662 0.192006810211669 0.745824956959977 NA NA NA 0.671467562323589 99.5502766024175 a8668 loss_cnaBRCA28_(GPS2) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 4 45 3.68887945411394 NA 3.27159661367865 3.47615746156735 -0.204560847888698 0.985925143136837 1.21609042670146 0.170082452050403 0.207481114882478 0.16821187256901 0.745882679757693 NA NA NA 0.717454682051013 99.5502766024175 a8669 ARID1A_mut 155 AP-24534 ABL 5 42 -0.669430653942629 NA 1.60279869551024 1.42661703060491 0.176181664905332 1.21862440236781 1.1344612788355 0.154248513529272 0.144574213812729 0.15529984865255 0.745899406169293 NA NA NA 0.770987067934522 99.5502766024175 a8670 BRCA1_mut 277 ABT-869 VEGFR and PDGFR family 4 44 0.0237165266173161 NA 2.76574610572203 2.68429026085222 0.0814558448698106 0.539541800916784 0.473938444319905 0.170234790672107 0.150972259668114 0.171870093777049 0.745921760631204 NA NA NA 0.78713919515165 99.5502766024175 a8671 gain_cnaBRCA14_(RAD21) 1043 JNK Inhibitor VIII JNK 19 24 2.30258509299405 NA 4.83933854374186 4.76407535247886 0.0752631912630015 0.915884249653896 0.591475892428371 0.100170620299817 0.0821754400640068 0.127246422426449 0.745929691783349 NA NA NA 0.758319528705703 99.5502766024175 a8672 loss_cnaBRCA33 1005 Cisplatin DNA crosslinker 5 40 1.79175946922805 2.30258509299405 3.50641736041142 3.69054182548299 -0.184124465071573 1.42248160399003 1.16439845889828 0.154626622905108 0.129438907719515 0.158128399831262 0.746019497014115 NA NA NA 0.792818036202746 99.5502766024175 a8673 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1028 VX-702 p38 17 28 0.693147180559945 NA 3.46975151257771 3.4007728113356 0.0689787012421146 0.811715161409616 0.603694105849511 0.100189941087919 0.0849789489238157 0.114261014930813 0.746116294090239 NA NA NA 0.764118087416779 99.5502766024175 a8674 gain_cnaBRCA19 1021 Axitinib PDGFR, KIT, VEGFR 4 41 0.693147180559945 NA 2.27913301957086 2.480226869506 -0.201093849935139 0.824700436905824 1.20076972527827 0.170645094502012 0.243838660604594 0.167470786198025 0.746179351228724 NA NA NA 0.678269262135681 99.5502766024175 a8675 gain_cnaBRCA9_(KRAS) 1006 Cytarabine DNA synthesis 4 41 0.693147180559945 NA 1.44751584030486 1.18521790254901 0.262297937755854 1.1372997632751 1.56490049801299 0.170441963735488 0.230632192343477 0.167613172907097 0.746470746831265 NA NA NA 0.692533315843646 99.5502766024175 a8676 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 8 35 1.6094379124341 NA 2.71880585679083 2.90205109181293 -0.1832452350221 1.49562158762718 1.42526846655422 0.127472841090858 0.122521122012434 0.128568925309292 0.746620468760657 NA NA NA 0.758900652350573 99.5502766024175 a8677 loss_cnaBRCA33 1046 681640 WEE1, CHEK1 4 32 0.693147180559945 NA 2.79896135859525 2.61314907422666 0.185812284368593 0.879833142439952 1.09277281326688 0.172739214331995 0.211190367134043 0.170037433318917 0.746632286967617 NA NA NA 0.717527651460444 99.5502766024175 a8678 NF1_mut 140 Vinorelbine Microtubules 4 43 -2.74887219562247 NA -3.34222759817659 -3.62377893131506 0.281551333138467 1.36928754236033 1.6757486279961 0.169907894819117 0.205618852453108 0.16801525505359 0.746661665457164 NA NA NA 0.720176876607905 99.5502766024175 a8679 gain_cnaBRCA31 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 10 16 2.30258509299405 NA 4.76722926360381 4.63489333812862 0.13233592547519 1.13206889116936 0.920647844476989 0.13165715426758 0.116897413671084 0.143742177064857 0.746800716706838 NA NA NA 0.759784228354615 99.5502766024175 a8680 loss_cnaBRCA33 1170 CCT018159 HSP90 4 39 2.30258509299405 NA 3.15714296901413 3.36187307089694 -0.204730101882815 1.39852568695861 1.18273188478086 0.170631394155613 0.146389947493952 0.173099334276211 0.746831642635479 NA NA NA 0.793588976513068 99.5502766024175 a8681 loss_cnaBRCA33 53 CGP-60474 CDK1,CDK2,CDK5,CDK7,CDK9 4 8 -1.36257783450257 NA -1.9102201325458 -1.59521575927281 -0.31500437327299 0.669815518179954 1.80098710688038 0.203119423413844 0.470285272173047 0.174906512139686 0.746968231845215 NA NA NA 0.671109477462027 99.5502766024175 a8682 ARID1A_mut 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 5 43 2.32630161961136 NA 5.05464079697471 4.94731012516351 0.107330671811199 0.639466481987412 0.705858632733262 0.153256120696475 0.167844093215994 0.152056894729172 0.747141995239236 NA NA NA 0.739175514903686 99.5502766024175 a8683 loss_cnaBRCA18 1007 Docetaxel Microtubules 14 31 -4.38202663467388 NA -4.69909556779668 -4.53678214676027 -0.162313421036412 1.6031378046349 1.53226984661397 0.104446377356596 0.101247329186013 0.10593004972009 0.74723550814054 NA NA NA 0.752659695518248 99.5502766024175 a8684 loss_cnaBRCA42 193 GW-2580 CSF1R (cFMS) 3 45 2.99573227355399 NA 5.59936665026344 5.45432368201218 0.145042968251255 0.199357494325048 0.766262311926721 0.193243420434983 0.72755212309584 0.189286313568722 0.74734719255259 NA NA NA 0.398709771246428 99.5502766024175 a8685 loss_cnaBRCA23 228 KIN001-102 AKT1 3 46 2.32630161961136 NA 2.20028285417023 1.92697016609815 0.273312688072079 0.635769253579225 1.44050851341525 0.193070005080791 0.42989289987428 0.189733476426385 0.747369169124656 NA NA NA 0.558563742482725 99.5502766024175 a8686 gain_cnaBRCA47_(EGFR) 329 QL-XI-92 DDR1 7 41 2.32630161961136 NA 4.14550242424462 4.27174555472037 -0.126243130475748 0.586112958794668 0.996181060129984 0.132503083808708 0.215390444079867 0.126727093626208 0.747405931950224 NA NA NA 0.648735233707236 99.5502766024175 a8687 PTEN_mut 276 CAY10603 HDAC6 9 40 2.99573227355399 NA 1.27291360169339 1.15363062772528 0.11928297396811 1.29704661625719 0.924833606825638 0.119517138822833 0.0919650631465487 0.128977767554892 0.747410087572037 NA NA NA 0.799173547000644 99.5502766024175 a8688 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1133 JNJ-26854165 MDM2 5 38 2.30258509299405 NA 2.84912970211271 2.98456394910223 -0.135434246989519 0.682487735340139 0.897278571016307 0.154141144321374 0.198442023169868 0.150938907229355 0.747576091885941 NA NA NA 0.702664042312079 99.5502766024175 a8689 POLR2B_mut 291 KIN001-266 MAP3K8 (COT) 3 46 2.99573227355399 NA 3.56364909062876 3.79265519059219 -0.229006099963426 0.717366874962284 1.2039770302358 0.192873263358382 0.319231495007998 0.190208030728439 0.747617560373818 NA NA NA 0.648638960763682 99.5502766024175 a8690 gain_cnaBRCA62 260 NG-25 MAP3K7 (TAK1) 10 39 2.32630161961136 NA 3.09024754350888 3.238624394718 -0.148376851209117 1.44230265872823 1.25545169137817 0.114725281192165 0.102874975866681 0.118186029958856 0.747628851794567 NA NA NA 0.770748652592483 99.5502766024175 a8691 loss_cnaBRCA23 204 Tipifarnib Farnesyl-transferase (FNTA) 3 45 2.77258872223978 NA 1.89570794517131 1.60159443298999 0.294113512181317 1.18472005257004 1.53744566393768 0.193012123122681 0.248255705255676 0.191300101902814 0.747638968181762 NA NA NA 0.716144807791256 99.5502766024175 a8692 gain_cnaBRCA15 193 GW-2580 CSF1R (cFMS) 22 26 2.99573227355399 NA 5.50149744041152 5.43114315201097 0.0703542884005506 0.915261767506502 0.576986420526805 0.0937339833016089 0.0768679419355849 0.121934045408408 0.74772663413337 NA NA NA 0.757010965541514 99.5502766024175 a8693 gain_cnaBRCA31 1038 NU-7441 PRKDC (DNAPK) 13 30 0.693147180559945 NA 2.96424401893484 2.8619341142594 0.102309904675443 1.16209692624668 0.8494101570828 0.107510930184659 0.0880390459390355 0.120448176681586 0.747750115389964 NA NA NA 0.778148449314715 99.5502766024175 a8694 gain_cnaBRCA9_(KRAS) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 4 43 -2.30258509299405 NA 0.0208920670157748 -0.155628873643302 0.176520940659077 0.646238612131762 1.06675226010616 0.169081207072033 0.273151336588792 0.165475103508579 0.747850919575728 NA NA NA 0.647524623926481 99.5502766024175 a8695 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1143 HG-5-88-01 EGFR, ADCK4 3 23 2.30258509299405 NA 4.70861129727222 4.51131171040186 0.197299586870363 1.09706000608451 0.980139912866114 0.199209894299062 0.179843933582576 0.201297370182 0.748351920352753 NA NA NA 0.790308238147848 99.5502766024175 a8696 gain_cnaBRCA47_(EGFR) 274 PXD101, Belinostat HDAC 7 41 2.99573227355399 NA 0.501796664027589 0.700477657516305 -0.198680993488716 1.05096580849486 1.56217189995187 0.131981482836232 0.189046105860719 0.127182542135624 0.748365477579515 NA NA NA 0.678077864648381 99.5502766024175 a8697 loss_cnaBRCA36_(FAT1,IRF2) 290 KIN001-260 IKK 9 40 2.99573227355399 NA 5.14596276807317 5.02114858007272 0.124814188000456 0.736197251434724 1.10166764046495 0.119041257805354 0.169539057307283 0.113295683213296 0.74838065651295 NA NA NA 0.683450625693107 99.5502766024175 a8698 PTEN_mut 1019 Bosutinib SRC, ABL, TEC 7 38 0.693147180559945 NA 2.76806142843504 2.64317116262905 0.124890265805987 1.09070597241335 0.913861597706099 0.13278629247952 0.114504063390841 0.13666212271035 0.748380813183816 NA NA NA 0.783168284613578 99.5502766024175 a8699 gain_cnaBRCA13_(FGFR1,WHSC1L1) 83 JW-7-52-1 MTOR 3 9 0.182321556793955 NA -1.64899811959318 -2.14355438879366 0.494556269200474 3.99193971410406 1.53092368029529 0.219811505389144 0.123888711909436 0.323044365676729 0.748416229219298 NA NA NA 0.851877472747607 99.5502766024175 a8700 loss_cnaBRCA28_(GPS2) 1072 BMS-708163 g-secretase 4 42 1.6094379124341 NA 3.83244112061841 3.67013630684448 0.162304813773932 1.28269058676264 0.933521805668065 0.168827318178577 0.126534657265685 0.173862905813732 0.748495948688459 NA NA NA 0.819507963365403 99.5502766024175 a8701 gain_cnaBRCA19 1006 Cytarabine DNA synthesis 4 41 0.693147180559945 NA 1.44551444064316 1.18541316105259 0.260101279590568 1.26383041755977 1.55763663242835 0.169011098523859 0.205803940130494 0.166984567629918 0.748524415892565 NA NA NA 0.720671774200699 99.5502766024175 a8702 loss_cnaBRCA17 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 36 1.38629436111989 0.693147180559945 3.30513079701075 3.45481295537848 -0.149682158367722 1.30506668192817 1.01062513730267 0.142290578727936 0.114693111425214 0.148108485374924 0.748614749189436 NA NA NA 0.797709857393424 99.5502766024175 a8703 gain_cnaBRCA8_(CHD4,WNK1) 156 AZD6482 PI3Kbeta 3 44 1.63315443905142 NA 1.78828476638038 2.07137969073677 -0.283094924356386 1.56131886809337 1.46715187822783 0.19238983942912 0.18131781415163 0.192955431920474 0.748628771157493 NA NA NA 0.786326299286785 99.5502766024175 a8704 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 277 ABT-869 VEGFR and PDGFR family 9 39 0.0237165266173161 NA 2.64473348206377 2.70177319389262 -0.0570397118288479 0.335304779286355 0.503487252670393 0.119204408585276 0.170113029555523 0.113289286921012 0.748649432192828 NA NA NA 0.683980859686837 99.5502766024175 a8705 gain_cnaBRCA58_(CCND1) 186 Bexarotene Retinioic acid X family agonist 9 38 2.07944154167984 NA 3.49356429669602 3.63065731722368 -0.137093020527665 1.17188192086635 1.14233859185185 0.119455809361355 0.116985353290812 0.120010845738323 0.748767702796155 NA NA NA 0.75668410230221 99.5502766024175 a8706 loss_cnaBRCA22_(SYNCRIP,ZNF292) 302 PI-103 PI3Ka, PRKDC (DNAPK) 18 30 2.32630161961136 NA 1.01644274720006 1.19562740672755 -0.179184659527493 1.89796737761808 1.84691321792333 0.0960289693318654 0.0944087141014861 0.097018450996289 0.748843041824208 NA NA NA 0.750971212279049 99.5502766024175 a8707 gain_cnaBRCA31 286 KIN001-236 TIE2 16 33 2.32630161961136 NA 4.59110358886938 4.51537691317067 0.0757266756987027 0.720406567922212 0.794849793773908 0.0981078460528234 0.105116581484137 0.0952716806267963 0.74884327460666 NA NA NA 0.74094629432388 99.5502766024175 a8708 CDH1_mut 1030 KU-55933 ATM 4 38 2.30258509299405 NA 4.36466083994048 4.20731393558551 0.157346904354965 1.47789051031952 0.86959002711428 0.169348419592969 0.106467226940206 0.180943777468467 0.749005508049251 NA NA NA 0.846858526882356 99.5502766024175 a8709 TP53_mut 282 EKB-569 EGFR 36 11 0.916290731874155 2.99573227355399 1.52280073312857 1.75894035038413 -0.236139617255558 2.1203883620675 2.16245333149995 0.110873667833142 0.111366210775326 0.109199867491135 0.7490714442013 NA NA NA 0.75420807723422 99.5502766024175 a8710 gain_cnaBRCA10_(MDM2,NUP107) 1259 BMN-673 PARP1 3 43 2.30258509299405 NA 3.02404580315171 3.32517703379973 -0.30113123064802 0.894451518666584 1.59243988153404 0.192112851943682 0.336665793912381 0.189100533175502 0.749191466112772 NA NA NA 0.634533152546639 99.5502766024175 a8711 gain_cnaBRCA30_(CRNKL1,FOXA2) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 4 39 1.6094379124341 NA 3.17807753043017 2.92209419403898 0.25598333639119 2.11049133144004 1.45906556750241 0.168826519474577 0.121290873161998 0.175443339965438 0.749415976274012 NA NA NA 0.826726468781324 99.5502766024175 a8712 gain_cnaBRCA13_(FGFR1,WHSC1L1) 3 Rapamycin MTOR 4 10 -2.30258509299405 NA -3.1174810157802 -2.59213658200992 -0.525344433770275 3.70601019484298 2.2946789273169 0.193345396240001 0.141754718997079 0.22894027897164 0.749439032885759 NA NA NA 0.80495727908153 99.5502766024175 a8713 PTEN_mut 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 8 35 1.6094379124341 NA 2.79045353592957 2.98143872576583 -0.190985189836264 0.863187060173425 1.61831648112813 0.125958700185928 0.221255853624465 0.118014734486994 0.749524991081051 NA NA NA 0.646222243168151 99.5502766024175 a8714 POLR2B_mut 272 AR-42 HDAC 3 46 1.63315443905142 NA 0.418485764750935 0.123934893496931 0.294550871254004 1.61167076002839 1.53644246980827 0.191301761696241 0.182761193265562 0.191709665049001 0.749602588713273 NA NA NA 0.78464976916207 99.5502766024175 a8715 loss_cnaBRCA34 193 GW-2580 CSF1R (cFMS) 5 43 2.99573227355399 NA 5.56538699200855 5.45152862049525 0.113858371513301 0.255588735402868 0.781546612664592 0.151692384481233 0.445474920222259 0.145683404762147 0.749632366673364 NA NA NA 0.500609411604141 99.5502766024175 a8716 BRCA1_mut 253 XMD14-99 EPHB3, CAMK1 4 44 2.32630161961136 NA 5.05261489933716 4.92223701666714 0.130377882670016 0.853943348219014 0.77252637466151 0.167560171349849 0.15267743807822 0.168768196072455 0.74977474215248 NA NA NA 0.785107880989844 99.5502766024175 a8717 gain_cnaBRCA48 1114 Cetuximab EGFR 5 40 4.18661983833127 NA 6.16299145797628 6.29753425477768 -0.134542796801397 0.612537268927177 0.907040595441915 0.152233114431984 0.219648344070624 0.148331615450847 0.749813864340602 NA NA NA 0.677671675302555 99.5502766024175 a8718 gain_cnaBRCA48 1026 17-AAG HSP90 4 39 0 NA -1.17125196968618 -0.867996873870945 -0.303255095815239 1.72087576162997 1.80540916802075 0.168535120625984 0.176221376683232 0.167970286839572 0.749833494144901 NA NA NA 0.756325626178977 99.5502766024175 a8719 gain_cnaBRCA63 211 TL-2-105 CRAF 7 42 2.32630161961136 1.63315443905142 4.0304337403239 3.88707373588564 0.14336000443826 0.769477694725229 1.13504658428163 0.130899197618855 0.186308200251929 0.126303190039546 0.749907379054453 NA NA NA 0.681015070760037 99.5502766024175 a8720 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 283 GSK2126458 PI3K, MTOR 5 43 -2.05572501506252 0.0237165266173161 -3.27844000485412 -3.02941812483882 -0.249021880015299 1.41938847013183 1.66447309213257 0.151416804807504 0.175443076547021 0.149610036468805 0.75007152915239 NA NA NA 0.729575718748921 99.5502766024175 a8721 gain_cnaBRCA13_(FGFR1,WHSC1L1) 35 NVP-TAE684 ALK 4 10 0.693147180559945 NA 1.94497845216333 1.70425907905465 0.240719373108673 1.06797443752817 1.30340417668516 0.19277366769132 0.225398066329958 0.184685132528019 0.750152079061735 NA NA NA 0.731968266939992 99.5502766024175 a8722 gain_cnaBRCA9_(KRAS) 1022 AZD7762 CHEK1, CHEK2 4 41 0.693147180559945 NA 0.654862646367221 0.929130006520973 -0.274267360153751 1.42787913562801 1.64835637473843 0.167856453082052 0.192080235161586 0.166388388067643 0.750182985001846 NA NA NA 0.736878744882188 99.5502766024175 a8723 gain_cnaBRCA61_(NOTCH2) 326 GSK690693 AKT 3 45 2.32630161961136 NA 2.59188341236133 2.96275790638591 -0.370874494024585 0.80205274247921 1.97851449261209 0.190952041635115 0.462406615403098 0.187450986793099 0.750239351262292 NA NA NA 0.537069056099231 99.5502766024175 a8724 loss_cnaBRCA22_(SYNCRIP,ZNF292) 200 LAQ824 HDAC 18 30 0.0237165266173161 NA -2.76917449272577 -2.63364316018052 -0.135531332545243 1.18681007898773 1.54020964063435 0.0954520434414425 0.114197995909204 0.0879953799597197 0.750299918261965 NA NA NA 0.734244697071259 99.5502766024175 a8725 loss_cnaBRCA17 1030 KU-55933 ATM 6 36 2.30258509299405 NA 4.33477264402237 4.20355380688547 0.131218837136896 1.25380413235869 0.872964049415772 0.141225309154962 0.104656567760743 0.150314136332091 0.75043158088289 NA NA NA 0.81367264363291 99.5502766024175 a8726 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1042 BIRB 0796 p38, JNK2 6 37 2.30258509299405 NA 4.2537643067371 4.38489251372298 -0.131128206985881 0.954201195381006 0.927179583170861 0.140919745704038 0.137421968889404 0.141426978512012 0.750446911901518 NA NA NA 0.763558206518086 99.5502766024175 a8727 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1054 PD-0332991 CDK4, CDK6 16 26 1.38629436111989 0.693147180559945 2.78992354311565 2.94012393536192 -0.150200392246263 1.64176979467727 1.36767916546667 0.101731587919778 0.0914868775958867 0.109821364570552 0.750507537261947 NA NA NA 0.761653621272026 99.5502766024175 a8728 gain_cnaBRCA10_(MDM2,NUP107) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 5 42 2.32630161961136 NA 1.62559536979036 1.39209590777839 0.233499462011976 1.30245975939261 1.56429978890561 0.151345334344188 0.179275759061352 0.149267719440999 0.750516120030476 NA NA NA 0.725030960214309 99.5502766024175 a8729 BRCA1_mut 1024 CEP-701 FLT3, JAK2, NTRK1, RET 4 41 0.693147180559945 NA 0.846229092373313 0.604041100890573 0.242187991482741 0.605917810800672 1.48967073028915 0.167528511575608 0.399704361161968 0.16257820373213 0.75065426898316 NA NA NA 0.54518181817916 99.5502766024175 a8730 loss_cnaBRCA28_(GPS2) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 4 45 1.63315443905142 NA 3.73073489618651 3.56296107614974 0.167773820036769 0.77949193204319 1.0199300809739 0.166723318828945 0.215234838411994 0.164495413133189 0.750727941370858 NA NA NA 0.709009839020766 99.5502766024175 a8731 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 333 T0901317 LXR 9 39 2.32630161961136 NA 4.66156323012004 4.75248381585501 -0.0909205857349695 0.616863615256943 0.797832390305193 0.118167203262501 0.147391714288576 0.113959506833496 0.75076121515389 NA NA NA 0.712518432280763 99.5502766024175 a8732 gain_cnaBRCA19 157 JNK-9L JNK 4 43 1.63315443905142 NA -0.10657404048287 0.0709529804593992 -0.177527020942269 0.367541253005988 1.09563925884215 0.167047521222443 0.483012504012378 0.162030540170564 0.750779169121412 NA NA NA 0.491867916759838 99.5502766024175 a8733 loss_cnaBRCA38 1017 Olaparib PARP1, PARP2 3 42 1.6094379124341 NA 3.91447059029094 4.08550006264114 -0.171029472350194 0.631248557291242 0.906510837954053 0.190969364514891 0.270938397204582 0.188667873774348 0.75085471429383 NA NA NA 0.694747208273892 99.5502766024175 a8734 ARID1A_mut 179 5-Fluorouracil DNA antimetabolite 5 44 3.46573590279973 NA 3.82125527158487 4.06650184901635 -0.245246577431477 2.33220025131238 1.5468529638945 0.150596317471445 0.105156740847391 0.158545500545844 0.751064151182541 NA NA NA 0.82876054131244 99.5502766024175 a8735 loss_cnaBRCA23 344 THZ-2-49 CDK9 3 46 2.99573227355399 NA 1.52064827597004 1.80253325968429 -0.281884983714258 0.72330146265336 1.50808550471664 0.190055258684586 0.389719913851951 0.186915783510048 0.75117831704952 NA NA NA 0.58989603085345 99.5502766024175 a8736 loss_cnaBRCA20 1007 Docetaxel Microtubules 3 42 -4.38202663467388 NA -4.3107067675709 -4.60703486180974 0.296328094238839 1.67410507118061 1.5480054180756 0.190675366545463 0.177006867334715 0.191425747467485 0.751225148383137 NA NA NA 0.791240664480467 99.5502766024175 a8737 BRCA2_mut 1262 UNC1215 LMBL3 5 41 0 NA 2.6769743216175 2.76734299133698 -0.0903686697194788 0.731188820916678 0.583025616112974 0.151114685159094 0.123591426912388 0.154999484108376 0.751228284834135 NA NA NA 0.801479291859484 99.5502766024175 a8738 loss_cnaBRCA57 1072 BMS-708163 g-secretase 4 42 1.6094379124341 NA 3.83067654623256 3.6703043615479 0.160372184684661 0.640250521772226 0.980771003461345 0.166812351772988 0.250483489245346 0.163516441777616 0.751394624797918 NA NA NA 0.671719803149334 99.5502766024175 a8739 gain_cnaBRCA9_(KRAS) 258 STF-62247 stimulates autophagy 4 45 2.32630161961136 NA 4.77853161674576 4.61771501992757 0.160816596818189 0.401191471796384 0.994348242972457 0.166233307550978 0.400847495830639 0.161730659207937 0.751435594846727 NA NA NA 0.53954984506111 99.5502766024175 a8740 gain_cnaBRCA19 1149 TW 37 BCL2, BCL2L1 3 40 1.6094379124341 NA -0.365386100497898 -0.12565910294367 -0.239726997554228 1.3706183772605 1.24993372283768 0.190851794769678 0.174904263310242 0.19179176717465 0.751477693183734 NA NA NA 0.793687386955799 99.5502766024175 a8741 POLR2B_mut 1527 GDC0941 (rescreen) PI3K 3 42 1.38629436111989 NA 1.1875771751973 0.96587574608978 0.221701429107516 1.22937711495524 1.16085250336891 0.190444016545835 0.180336388574786 0.190981566102599 0.751516688483638 NA NA NA 0.78761607781119 99.5502766024175 a8742 ASH1L_mut 1199 Tamoxifen ER 3 44 1.6094379124341 NA 4.03986135933134 3.85753219022256 0.182329169108776 0.537337438773742 0.97461138448205 0.19004136463278 0.339319682478983 0.187078841897249 0.751592121995279 NA NA NA 0.632224065446344 99.5502766024175 a8743 gain_cnaBRCA14_(RAD21) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 18 24 -1.38629436111989 0.693147180559945 -0.205255009451218 -0.374975038334565 0.169720028883346 1.40414821813273 1.90233149006978 0.0993417002014124 0.120870451346685 0.0892168529876573 0.751685851643636 NA NA NA 0.741141035573223 99.5513036278355 a8744 CDH1_mut 1018 ABT-888 PARP1, PARP2 4 41 1.6094379124341 NA 4.30152834925567 4.41298329863328 -0.111454949377602 1.07604895282149 0.627904150694918 0.166603369489748 0.103577954409376 0.177503125682879 0.751984307219806 NA NA NA 0.850782186245851 99.5794406827325 a8745 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 151 QS11 ARFGAP 7 41 2.32630161961136 NA 3.92580895970005 3.7322178569358 0.193591102764243 1.04174591291726 1.54651222410323 0.129892063140462 0.185833321123498 0.125179161048339 0.752213231499774 NA NA NA 0.683116257862502 99.5983648660478 a8746 gain_cnaBRCA48 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 4 39 1.6094379124341 NA 3.08529341248018 2.84566824148355 0.239625170996628 0.429089093135281 1.48840642063934 0.166682850105875 0.558450855149282 0.1609944486088 0.752489210016041 NA NA NA 0.467855684483257 99.6196392164795 a8747 TP53_mut 226 GSK1070916 AURKB 38 11 0.940007258491471 2.32630161961136 2.3561750088728 2.5689806740079 -0.212805665135106 1.86200225013644 2.28724990864561 0.108562035893224 0.114288618673534 0.0930399709846828 0.752587578034466 NA NA NA 0.781558426586029 99.6196392164795 a8748 loss_cnaBRCA18 262 VX-11e ERK 16 33 1.63315443905142 NA 3.68976742239239 3.81901534931183 -0.129247926919439 1.04682765235329 1.45603419361462 0.0965190831390761 0.123466290395451 0.0887670959145397 0.752772459095275 NA NA NA 0.724639635714896 99.6196392164795 a8749 loss_cnaBRCA42 156 AZD6482 PI3Kbeta 3 44 1.63315443905142 NA 1.792838691386 2.07106919585002 -0.278230504464017 1.04674843386154 1.48833234756474 0.189076564338403 0.265804557679253 0.186941112258473 0.752810626590435 NA NA NA 0.699420822054915 99.6196392164795 a8750 loss_cnaBRCA34 265 Tubastatin A HDAC6 5 44 2.99573227355399 NA 4.55200686661758 4.70764047362356 -0.155633607005983 0.842504242782148 1.05823500359541 0.149415548493246 0.184727386644421 0.147069040881476 0.752950089703184 NA NA NA 0.717807487682502 99.6196392164795 a8751 gain_cnaBRCA62 305 TPCA-1 IKK 10 39 2.99573227355399 NA 4.30239241940242 4.14651455700628 0.155877862396133 1.58541231923771 1.33924085640917 0.112161740029991 0.0983200776887378 0.116392702365786 0.753076548307371 NA NA NA 0.779667741525482 99.6196392164795 a8752 loss_cnaBRCA7_(FAS,PTEN) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 4 42 0 NA 0.339722050843054 0.68307163061938 -0.343349579776326 0.932456629971727 2.13326657168521 0.165581238449102 0.368220428425434 0.160950152378327 0.753167461590527 NA NA NA 0.567468019209641 99.6196392164795 a8753 gain_cnaBRCA48 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 5 43 2.77258872223978 NA -0.626196751145128 -0.414472602746974 -0.211724148398154 2.16584130906101 1.32377880137937 0.14941639561616 0.0977560763627444 0.159939219586792 0.753261871928584 NA NA NA 0.840206313446025 99.6196392164795 a8754 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 290 KIN001-260 IKK 7 42 2.99573227355399 NA 4.92813509522627 5.0633967249758 -0.135261629749528 2.33254029361194 0.681270306689776 0.128999639617739 0.0579889788484962 0.198543263109104 0.753414190805067 NA NA NA 0.883773569592409 99.6196392164795 a8755 gain_cnaBRCA12_(TERT) 1021 Axitinib PDGFR, KIT, VEGFR 10 35 0.693147180559945 NA 2.56623645427282 2.43267054815146 0.133565906121356 1.54507030335622 1.06049034034144 0.113333755997504 0.0864464910310055 0.12594731044731 0.75347647463893 NA NA NA 0.801977802739749 99.6196392164795 a8756 gain_cnaBRCA12_(TERT) 1527 GDC0941 (rescreen) PI3K 9 36 1.38629436111989 NA 0.870968860857584 1.00807758649012 -0.137108725632538 0.998379911250001 1.19882834955008 0.117775637749172 0.137331214387992 0.114368938375536 0.753512313874535 NA NA NA 0.729047122588271 99.6196392164795 a8757 gain_cnaBRCA48 281 CH5424802 ALK 5 43 1.63315443905142 NA 3.43192980699053 3.59190355849578 -0.159973751505244 0.944203933143007 1.08327193871793 0.149243785976457 0.169427118326793 0.147676447425173 0.753537362532445 NA NA NA 0.737814897432485 99.6196392164795 a8758 gain_cnaBRCA12_(TERT) 185 OSI-906 IGF1R 9 39 0.940007258491471 NA 2.78577473022151 2.91834726237556 -0.132572532154046 1.45928428364672 1.05439447086879 0.116780201747703 0.0908476392432253 0.125733333981551 0.753588208357962 NA NA NA 0.802026782054329 99.6196392164795 a8759 gain_cnaBRCA8_(CHD4,WNK1) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 3 40 1.6094379124341 NA 3.12082212010835 2.84899421768636 0.271827902421989 1.14820490070186 1.45091617714015 0.189080660301496 0.23674163231304 0.187349143048208 0.753706259261787 NA NA NA 0.728894413405616 99.6196392164795 a8760 loss_cnaBRCA23 185 OSI-906 IGF1R 3 45 0.940007258491471 NA 3.09376596356008 2.88013817586578 0.213627787694302 0.669791905195467 1.15192943143459 0.188179712529364 0.31894650567919 0.185452148252046 0.753743411366176 NA NA NA 0.649938988486229 99.6196392164795 a8761 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 341 EX-527 SIRT1 7 42 2.99573227355399 NA 5.71438820504241 5.62964741108382 0.0847407939585878 0.821423662658703 0.631406422162488 0.128644029219089 0.103163322181768 0.134209585116922 0.754071276654028 NA NA NA 0.801799764030395 99.6196392164795 a8762 loss_cnaBRCA60 193 GW-2580 CSF1R (cFMS) 3 45 2.99573227355399 NA 5.59560043491322 5.45457476303553 0.141025671877694 0.205714743666479 0.766233866028617 0.18787938611828 0.68553993439739 0.184050429157652 0.754123322344821 NA NA NA 0.419907512133051 99.6196392164795 a8763 loss_cnaBRCA34 1248 FK866 NAMPT 5 39 0 NA -1.01307523251507 -0.604248259834191 -0.408826972680882 3.19028675941712 2.68059048136854 0.149576436616208 0.12814740602051 0.15251377467854 0.754406889100704 NA NA NA 0.795303777685313 99.6196392164795 a8764 BRCA2_mut 202 GSK-1904529A IGF1R 6 42 0.0237165266173161 NA 2.08901134311575 2.20405486515792 -0.115043522042169 0.543632218774276 0.867385675912072 0.137238561065378 0.211620132268019 0.132632490064121 0.754598813321808 NA NA NA 0.667432384421331 99.6196392164795 a8765 gain_cnaBRCA47_(EGFR) 151 QS11 ARFGAP 7 41 2.32630161961136 NA 3.92414172729295 3.73250250637116 0.191639220921787 1.47749201858831 1.4923639765814 0.128579598005748 0.129705757128144 0.128413191372242 0.754633454679519 NA NA NA 0.759355690189981 99.6196392164795 a8766 gain_cnaBRCA12_(TERT) 1149 TW 37 BCL2, BCL2L1 10 33 1.6094379124341 NA -0.251862344866902 -0.109209059714288 -0.142653285152614 0.600799340213187 1.38568342325261 0.113565643502018 0.237439150818633 0.102947962542386 0.754654818776926 NA NA NA 0.645064785532169 99.6196392164795 a8767 loss_cnaBRCA7_(FAS,PTEN) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 38 1.38629436111989 0.693147180559945 3.59070087308523 3.41687493903549 0.173825934049739 0.553537491560158 1.08241931341738 0.165231128758609 0.31402739055634 0.160590200022337 0.754902346104096 NA NA NA 0.615482334210298 99.6196392164795 a8768 gain_cnaBRCA15 1170 CCT018159 HSP90 21 22 2.30258509299405 NA 3.28397773405565 3.3990040557213 -0.115026321665649 1.1716463606165 1.22627780036548 0.095860134245835 0.0981749489710564 0.0938011938496861 0.754952239522246 NA NA NA 0.754695093705993 99.6196392164795 a8769 loss_cnaBRCA17 91 KIN001-135 IKKE 4 10 1.6094379124341 NA 3.64743234669793 3.72584076560313 -0.0784084189052008 0.630078421159806 0.312101979427463 0.188891842973376 0.124442317451329 0.251226919640297 0.75499974346448 NA NA NA 0.825139786334209 99.6196392164795 a8770 loss_cnaBRCA60 158 PF-562271 FAK 3 42 0.940007258491471 NA 2.56045860262735 2.31702103433418 0.243437568293168 0.977164234551271 1.31150403086385 0.187567773160143 0.249126564077489 0.185617095002616 0.755144294520026 NA NA NA 0.716299596722467 99.6196392164795 a8771 gain_cnaBRCA9_(KRAS) 1010 Gefitinib EGFR 4 41 -0.693147180559945 NA 1.24279214205393 1.41522519737379 -0.172433055319864 1.02692419392902 1.05056137344268 0.164389548265013 0.167912155872123 0.164134204510873 0.755170115756045 NA NA NA 0.766554501160779 99.6196392164795 a8772 gain_cnaBRCA15 294 MPS-1-IN-1 MPS1 22 27 2.99573227355399 NA 4.69795752812477 4.80423340096335 -0.106275872838578 1.2732919627183 1.09858144711966 0.0900761149179661 0.0834654391532435 0.0967391840789052 0.755196777365738 NA NA NA 0.758957921621746 99.6196392164795 a8773 gain_cnaBRCA14_(RAD21) 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 13 13 2.30258509299405 NA 2.76860001968006 2.61448518943582 0.15411483024424 1.40344357834519 1.06804289379671 0.123581493019996 0.109811917359697 0.14429648016887 0.755429952473618 NA NA NA 0.755622089138474 99.6196392164795 a8774 gain_cnaBRCA63 71 Pyrimethamine Dihydrofolate reductase (DHFR) 3 11 2.99573227355399 NA 4.40164974129486 4.61534914293038 -0.213699401635512 1.46173517942563 0.919007678765527 0.207570627684947 0.146195702643951 0.232532770479749 0.755445442083209 NA NA NA 0.828566639052144 99.6196392164795 a8775 PTEN_mut 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 8 38 0 NA 0.444390569141837 0.697178214111881 -0.252787644970044 1.09968667910161 2.21014474371288 0.121904850871613 0.229872426186483 0.114376058712508 0.755468629849391 NA NA NA 0.637589008622626 99.6196392164795 a8776 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1020 Lenalidomide TNFA 15 30 1.6094379124341 NA 4.20747353002888 4.27835310031178 -0.0708795702829059 0.733023356223526 0.706498345718737 0.0990986693073668 0.0966948320010858 0.100325175157768 0.755508964059724 NA NA NA 0.759328213767431 99.6196392164795 a8777 gain_cnaBRCA47_(EGFR) 1375 Temozolomide DNA akylating agent 6 40 3.40119738166216 NA 5.98390590200596 5.88755894042813 0.0963469615778285 0.599046216399241 0.715018472349043 0.13708932925335 0.160833937249371 0.134747513950655 0.755658315895239 NA NA NA 0.730728887823279 99.6196392164795 a8778 loss_cnaBRCA34 1069 EHT 1864 Rac GTPases 4 42 2.30258509299405 NA 3.69074915492363 3.54910479157593 0.141644363347704 0.793772812473071 0.869568014746856 0.163824333691109 0.178444463103237 0.162890493837838 0.755699783501016 NA NA NA 0.753498208044664 99.6196392164795 a8779 gain_cnaBRCA27_(CLTC,PPM1D) 1019 Bosutinib SRC, ABL, TEC 10 35 0.693147180559945 NA 2.74472801588989 2.63913297200143 0.10559504388846 0.752043318573663 0.984489727849861 0.112263076902748 0.140410853045983 0.1072586548151 0.755728321224892 NA NA NA 0.72007174955869 99.6196392164795 a8780 gain_cnaBRCA47_(EGFR) 178 BAY 61-3606 SYK 7 41 2.07944154167984 NA 2.91901651889493 3.1259273123764 -0.206910793481474 1.60631608696636 1.61859925423517 0.127959484982349 0.128810758455541 0.127833244047332 0.755777828732393 NA NA NA 0.76088467361099 99.6196392164795 a8781 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 258 STF-62247 stimulates autophagy 6 43 2.32630161961136 NA 4.51511866788017 4.64699047340564 -0.131871805525468 1.40321312385969 0.901656120181048 0.136308254573973 0.093978457928572 0.146255099448544 0.755834216574312 NA NA NA 0.830834327147492 99.6196392164795 a8782 loss_cnaBRCA17 1021 Axitinib PDGFR, KIT, VEGFR 8 37 0.693147180559945 NA 2.34413402390988 2.48791247396622 -0.14377845005634 0.867888472856397 1.22987235401723 0.121996499134573 0.165664661477915 0.116905180921179 0.755879347651956 NA NA NA 0.701537701097396 99.6196392164795 a8783 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1373 Dabrafenib BRAF 8 38 2.30258509299405 NA 4.0491092156857 4.24942700855591 -0.200317792870205 1.03634245921873 1.73770836482716 0.121682166998743 0.19329304815053 0.115276991769634 0.755900618715842 NA NA NA 0.670352885629023 99.6196392164795 a8784 gain_cnaBRCA16 51 Dasatinib ABL, SRC, KIT, PDGFR 3 9 0.246860077931526 NA 1.77872913179261 2.02757100869678 -0.248841876904168 1.75159648223695 0.969954387672782 0.212890184270216 0.142065755114085 0.256550081185998 0.756043238184159 NA NA NA 0.833047746234452 99.6196392164795 a8785 loss_cnaBRCA57 157 JNK-9L JNK 5 42 1.63315443905142 NA -0.0845384761464835 0.0725565328227405 -0.157095008969224 0.412943242291179 1.10592754177097 0.147814251229508 0.380427605734861 0.142048193064855 0.756143799748801 NA NA NA 0.543072930694658 99.6196392164795 a8786 CDH1_mut 1038 NU-7441 PRKDC (DNAPK) 4 39 0.693147180559945 NA 3.03448894179299 2.8783394847888 0.156149457004198 1.48890871922376 0.895676642686732 0.164073156781441 0.104875104153871 0.174336863955503 0.756236044533285 NA NA NA 0.849139572697654 99.6196392164795 a8787 gain_cnaBRCA64_(SDHC) 273 CUDC-101 HDAC, EGFR 8 41 1.63315443905142 NA 0.132757898287016 -0.0577522009691886 0.190510099256204 2.70188243919246 1.28482350586835 0.120678271536158 0.0705101363748245 0.148277252389968 0.756250409583619 NA NA NA 0.850354534141519 99.6196392164795 a8788 loss_cnaBRCA29_(MAP2K4) 204 Tipifarnib Farnesyl-transferase (FNTA) 7 41 2.77258872223978 NA 1.78609984907491 1.59161400918388 0.194485839891023 0.995366451159209 1.58811404663672 0.127621186481778 0.195391194533956 0.122463396317728 0.756402367903328 NA NA NA 0.673676628341361 99.6196392164795 a8789 loss_cnaBRCA7_(FAS,PTEN) 134 Etoposide TOP2 4 43 2.77258872223978 NA 2.80138148932696 2.44693613483248 0.354445354494481 1.80418381956154 2.19746316281711 0.163078877918963 0.196457451093104 0.161297518198252 0.756504174424924 NA NA NA 0.731845327870391 99.6196392164795 a8790 gain_cnaBRCA15 35 NVP-TAE684 ALK 6 8 0.693147180559945 NA 1.89530081121184 1.6813374664911 0.21396334472074 1.25326361110301 1.24594887744782 0.171307462837936 0.170724931949814 0.171727226207722 0.756542972523588 NA NA NA 0.757304036053396 99.6196392164795 a8791 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 184 BMS-754807 IGF1R 6 42 0.940007258491471 NA 1.42567418976991 1.65561106395273 -0.229936874182815 1.1162265723604 1.74663667205329 0.136093823329583 0.205994804170075 0.131645509258951 0.756578665679695 NA NA NA 0.674316940214118 99.6196392164795 a8792 gain_cnaBRCA47_(EGFR) 153 Midostaurin KIT 7 40 -0.669430653942629 NA 0.452874177673037 0.640063294753467 -0.187189117080431 1.15011580912583 1.50790316266415 0.127751934727158 0.162756755098174 0.124138685901889 0.756620989253012 NA NA NA 0.713640649747459 99.6196392164795 a8793 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 268 YM155 BIRC5 (Survivin) 15 34 1.63315443905142 NA -3.70338845235487 -3.54801456798649 -0.155373884368379 1.54127944942206 1.6361600060307 0.0965965297920463 0.100808379964217 0.0949625243226138 0.756694876140259 NA NA NA 0.751996472162674 99.6196392164795 a8794 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 230 GSK429286A ROCK2 15 34 2.99573227355399 2.32630161961136 5.34500927105702 5.43219225437951 -0.0871829833224824 0.765092480815969 0.955185367058265 0.0965740904518482 0.113950908561409 0.0912733657038576 0.75674955469483 NA NA NA 0.736204966559652 99.6196392164795 a8795 MLL3_mut 1243 piperlongumine Increases ROS levels 3 44 2.30258509299405 NA 1.85982698391295 1.70004854918522 0.159778434727739 1.00651750838321 0.851778107615398 0.185951617056765 0.158743820546544 0.187582227459505 0.756761668697084 NA NA NA 0.811442932261738 99.6196392164795 a8796 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 6 42 0.246860077931526 2.32630161961136 -0.462969805631658 -0.236663595039337 -0.226306210592321 1.41365126258782 1.69217735049892 0.135988055307993 0.160086307409401 0.13373669759 0.756761677647598 NA NA NA 0.731109060906565 99.6196392164795 a8797 CDH1_mut 306 TG101348 JAK2 4 44 2.32630161961136 NA 3.41743491534646 3.20738475132173 0.210050164024729 1.12203043146445 1.30252025402037 0.162638166884315 0.187205407388618 0.161264412876796 0.75688205892633 NA NA NA 0.742635808947281 99.624160058065 a8798 gain_cnaBRCA8_(CHD4,WNK1) 178 BAY 61-3606 SYK 3 45 2.07944154167984 NA 3.37713656123098 3.07699390568898 0.300142655542 1.97899563584088 1.59862026702706 0.185614686979594 0.151664132101266 0.187751063672033 0.756990125584609 NA NA NA 0.819342518783295 99.6270591514456 a8799 NF1_mut 1241 CHIR-99021 GSK3B 5 41 2.30258509299405 NA 4.36081327042621 4.2157156073724 0.145097663053815 0.922888955661294 0.990267215187329 0.1474071618825 0.157221150132678 0.146523747154819 0.757130686142361 NA NA NA 0.754868406260006 99.6282127821112 a8800 loss_cnaBRCA42 262 VX-11e ERK 3 46 1.63315443905142 NA 4.00966518372001 3.76162586379149 0.248039319928526 0.0835957079432113 1.36846725908876 0.185222090597262 2.96712984471673 0.181253382776356 0.757298094516761 NA NA NA 0.237873293539661 99.6282127821112 a8801 PIK3CA_mut 1248 FK866 NAMPT 15 29 0 NA -0.828916839659359 -0.558527782800635 -0.270389056858724 2.76115349450518 2.7192802202099 0.0989236971092368 0.0979261230485049 0.0994340542211031 0.757307481720199 NA NA NA 0.759231588215372 99.6282127821112 a8802 MACF1_mut 1031 Elesclomol HSP70 3 41 -1.6094379124341 NA -2.66593787726705 -3.00038208471492 0.334444207447862 3.23037049317909 1.69493217196394 0.186005848447462 0.103531222859433 0.197320112851676 0.757343059770397 NA NA NA 0.87486759391773 99.6282127821112 a8803 PIK3CA_mut 1001 AICAR AAPK1 (AMPK) agonist 16 29 7.60090245954208 NA 7.82516417788036 7.69065936070351 0.134504817176854 1.68056650236603 1.20658815967721 0.0967379999837615 0.0800354029355505 0.111475333234529 0.7575791978597 NA NA NA 0.78002386118157 99.6368407516943 a8804 loss_cnaBRCA20 295 NVP-BHG712 EPHB4 3 46 2.32630161961136 NA 4.10144159362046 3.87270390396108 0.228737689659376 0.353255663698166 1.26181815319332 0.184939013585887 0.647513155952731 0.181276271133445 0.757657019493324 NA NA NA 0.436649764280413 99.6368407516943 a8805 loss_cnaBRCA34 173 FH535 unknown 5 43 3.46573590279973 NA 1.4037340279508 1.59267993557476 -0.188945907623964 1.16060596185844 1.30003672305684 0.14663891019512 0.162799359845965 0.1453389002579 0.757698745152812 NA NA NA 0.747012323233132 99.6368407516943 a8806 gain_cnaBRCA13_(FGFR1,WHSC1L1) 238 CAL-101 PI3Kdelta 11 38 2.99573227355399 2.32630161961136 4.79732291654284 4.69628143868942 0.101041477853421 0.814010934663544 0.985389030495152 0.106190195342872 0.124127912231529 0.102539682020459 0.757816544521833 NA NA NA 0.733839826677858 99.6368407516943 a8807 loss_cnaBRCA17 1262 UNC1215 LMBL3 9 37 0 NA 2.81298861416039 2.74402801960703 0.0689605945533573 0.499573424534526 0.617807105389674 0.115308844868521 0.138038957171533 0.111621562704206 0.757838894982444 NA NA NA 0.728729461799972 99.6368407516943 a8808 POLR2B_mut 262 VX-11e ERK 3 46 1.63315443905142 NA 4.00868000493609 3.76169011458174 0.246989890354349 0.233738833646571 1.36770522035834 0.184436833670322 1.05669172084522 0.18058707876368 0.758293886720362 NA NA NA 0.322900173511854 99.6525253049836 a8809 gain_cnaBRCA13_(FGFR1,WHSC1L1) 344 THZ-2-49 CDK9 11 38 2.99573227355399 NA 1.9071629068651 1.74999165257557 0.157171254289532 1.34984686256885 1.51731450513502 0.105962856158559 0.116436359299621 0.103585152423984 0.75831834279092 NA NA NA 0.744878933238656 99.6525253049836 a8810 loss_cnaBRCA22_(SYNCRIP,ZNF292) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 16 30 1.63315443905142 NA 1.83640617850568 1.99002899799155 -0.153622819485873 1.7019393579515 1.54944030172188 0.0958310295400193 0.0902633920345886 0.0991472981018711 0.758355263304734 NA NA NA 0.765865381825602 99.6525253049836 a8811 loss_cnaBRCA7_(FAS,PTEN) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 4 44 2.07944154167984 NA 3.04117912762503 3.23004202565183 -0.188862898026807 1.5184853306996 1.1402596003294 0.161605850690154 0.124375846251866 0.165631491260629 0.758375433113209 NA NA NA 0.822555993978553 99.6525253049836 a8812 loss_cnaBRCA60 308 XL-880 MET 3 46 1.63315443905142 NA 1.56843168644732 1.86594426014662 -0.2975125736993 1.64235447500087 1.61336268411677 0.184263153196811 0.181150036869564 0.184405265243984 0.758514188647981 NA NA NA 0.786658696075989 99.6525253049836 a8813 gain_cnaBRCA10_(MDM2,NUP107) 1371 PLX4720 (rescreen) BRAF 3 44 2.30258509299405 NA 4.54084956527626 4.71848582867608 -0.177636263399819 0.813593792987234 0.969178033557393 0.184500186608709 0.218335322775264 0.18328548238738 0.758599036516392 NA NA NA 0.747340486856821 99.6525253049836 a8814 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1129 PF-4708671 RPS6KB1 (p70S6KA) 6 37 2.30258509299405 NA 3.67387755196113 3.83087330789544 -0.156995755934312 0.575439774778885 1.21197172074275 0.136126131051144 0.272827431844868 0.129537474552705 0.758657711056952 NA NA NA 0.618346671865107 99.6525253049836 a8815 gain_cnaBRCA47_(EGFR) 190 Bleomycin DNA damage 7 41 4.15888308335967 NA 1.78025816689253 2.12930127647718 -0.349043109584647 2.73283497461514 2.76575421033574 0.126396995235271 0.127721985713317 0.126201781879336 0.758663741188188 NA NA NA 0.762962216177277 99.6525253049836 a8816 gain_cnaBRCA15 235 QL-XII-47 BTK, BMX 22 27 2.32630161961136 NA 1.63406066415896 1.76838314943383 -0.134322485274865 1.47630963949326 1.54342644113901 0.0887316443711283 0.0909853066603093 0.0870287573768255 0.758732760245907 NA NA NA 0.757686605359836 99.6525253049836 a8817 gain_cnaBRCA15 208 SB-715992 KIF11 22 27 -2.05572501506252 NA -1.15603104716709 -1.30823636507811 0.152205317911023 1.97899757335737 1.47592334962237 0.0885432657847714 0.0769103105330276 0.10312548951134 0.759228617696352 NA NA NA 0.766379315057688 99.6988292593107 a8818 gain_cnaBRCA12_(TERT) 1046 681640 WEE1, CHEK1 8 28 0.693147180559945 NA 2.73736704981068 2.60420283611245 0.133164213698228 1.24985374667683 1.02593275381368 0.123775727380559 0.106543836870747 0.129798189211933 0.75939499615492 NA NA NA 0.788278023203424 99.6988292593107 a8819 gain_cnaBRCA10_(MDM2,NUP107) 1050 ZM-447439 AURKB 3 36 1.38629436111989 0.693147180559945 2.66070545365416 2.90685896721782 -0.246153513563658 1.49556358937167 1.31751537549716 0.185391440104606 0.164589132359845 0.186831606022642 0.759424649952154 NA NA NA 0.805522306415697 99.6988292593107 a8820 loss_cnaBRCA42 287 KIN001-244 PDPK1 (PDK1) 3 46 2.99573227355399 NA 3.31467028099453 3.48876489582649 -0.174094614831956 0.365681561622511 0.966598110196826 0.183486936148578 0.476082562269497 0.180110650947275 0.759499014547282 NA NA NA 0.530172770637218 99.6988292593107 a8821 gain_cnaBRCA9_(KRAS) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 4 41 2.30258509299405 NA 1.2022051401042 1.38123805193827 -0.179032911834077 1.23219097537593 1.10029889879245 0.161289556130277 0.145296399188004 0.16271297920098 0.75963841493404 NA NA NA 0.795365593154703 99.6988292593107 a8822 gain_cnaBRCA31 11 Paclitaxel Microtubules 3 9 -2.27886856637673 NA -2.80496708088488 -3.19061661934567 0.385649538460791 0.8515277473635 2.01232590458255 0.209623585809794 0.452891335197048 0.191643678383593 0.759652523164164 NA NA NA 0.654137916141264 99.6988292593107 a8823 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 9 38 -2.30258509299405 NA -0.0443719537570556 -0.163398045125931 0.119026091368876 1.11354749396377 1.02848940627668 0.113996847314803 0.106889101734846 0.115729039737776 0.759875171591548 NA NA NA 0.775148757737972 99.6988292593107 a8824 POLR2B_mut 265 Tubastatin A HDAC6 3 46 2.99573227355399 NA 4.5126941733588 4.70343766635757 -0.190743492998767 0.532220113805269 1.05864754781572 0.183111399725154 0.358392116440298 0.180176578496141 0.759975621275333 NA NA NA 0.61676653780413 99.6988292593107 a8825 gain_cnaBRCA9_(KRAS) 1495 AZD-2281 PARP1, PARP2 4 41 2.30258509299405 NA 4.16560218091162 3.98240730827666 0.183194872634965 0.356055728718298 1.17566253268693 0.161007536295901 0.514511796494373 0.155822668105515 0.760045330730727 NA NA NA 0.487757270843782 99.6988292593107 a8826 gain_cnaBRCA19 1004 Vinblastine Microtubules 4 41 -2.30258509299405 NA -3.64512735869867 -3.43706601388946 -0.208061344809214 1.59892129535259 1.26631354155414 0.161000855707597 0.130126070253717 0.164304761800038 0.760054970734078 NA NA NA 0.81515899667535 99.6988292593107 a8827 PIK3CA_mut 1170 CCT018159 HSP90 15 28 2.30258509299405 NA 3.41969202677318 3.30165147283713 0.118040553936051 1.48781287570871 1.0192562178371 0.0983670719997863 0.0793383064922209 0.115810482065576 0.760075588492531 NA NA NA 0.786217670294652 99.6988292593107 a8828 gain_cnaBRCA15 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 22 27 1.63315443905142 NA 3.52774370340724 3.61651209394538 -0.0887683905381382 1.22376342224566 0.788193902540511 0.0882052750016569 0.0725372150568483 0.112622528862529 0.760118546248549 NA NA NA 0.770423488510805 99.6988292593107 a8829 gain_cnaBRCA12_(TERT) 1047 Nutlin-3a MDM2 9 34 2.07944154167984 1.38629436111989 4.29913869075597 4.1825402414622 0.116598449293762 0.876071778087476 1.04293241243284 0.115154890556883 0.133092347237009 0.111798662985048 0.760252724502894 NA NA NA 0.738329996254472 99.705134183022 a8830 gain_cnaBRCA31 185 OSI-906 IGF1R 16 32 0.940007258491471 NA 2.82241729361297 2.92902622208852 -0.10660892847555 1.27009789319637 1.06396332636375 0.0939036666395656 0.0839375681564631 0.10019981500669 0.760464789698066 NA NA NA 0.774982802177077 99.7196777026855 a8831 gain_cnaBRCA14_(RAD21) 304 SB52334 ALK5 21 28 2.99573227355399 NA 4.23708570197136 4.35049628220772 -0.113410580236359 1.32849624719329 1.24563355767243 0.0884949018908911 0.085367633123512 0.0910465036348864 0.76053586129408 NA NA NA 0.762874621554995 99.7196777026855 a8832 ASH1L_mut 255 CP724714 ERBB2 3 45 2.32630161961136 NA 4.0907327176294 3.78385588305893 0.30687683457047 0.605675268423216 1.71241219885487 0.182716207947925 0.50666892073929 0.179207339667217 0.760664248131288 NA NA NA 0.512451281861584 99.7252188531724 a8833 loss_cnaBRCA60 202 GSK-1904529A IGF1R 3 45 0.0237165266173161 NA 2.33304430337023 2.18011643300481 0.152927870365423 0.389828306403267 0.853124339941407 0.182421372528492 0.392295448671764 0.179256250473321 0.761038296833791 NA NA NA 0.590548392914842 99.727107917785 a8834 NF1_mut 1011 ABT-263 BCL2, BCL2L1, BCL2L2 4 39 0.693147180559945 NA 1.43656239513138 1.70711467565081 -0.270552280519428 2.10993139922425 1.64506462692319 0.16071416327222 0.128227998606448 0.164463010201277 0.7610674274316 NA NA NA 0.817851476752855 99.727107917785 a8835 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 299 OSI-027 MTORC1/2 9 39 2.99573227355399 NA 1.45232709492413 1.22665628717805 0.225670807746078 1.46187092239965 2.09336770620621 0.11295219476665 0.154371226821887 0.107802755854613 0.761408083207003 NA NA NA 0.707637680029328 99.727107917785 a8836 POLR2B_mut 295 NVP-BHG712 EPHB4 3 46 2.32630161961136 NA 4.09797427237605 3.87293003360745 0.225044238768597 0.369407200488744 1.26165414629856 0.181946811936326 0.609203714683559 0.178372368868942 0.7614542388843 NA NA NA 0.456576671998198 99.727107917785 a8837 loss_cnaBRCA24 286 KIN001-236 TIE2 3 46 2.32630161961136 NA 4.67193890337412 4.53150606187869 0.140432841495423 0.732175806595332 0.773678520351114 0.181917745663743 0.191802078449499 0.181513170911985 0.761491154374018 NA NA NA 0.775237130954657 99.727107917785 a8838 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 283 GSK2126458 PI3K, MTOR 6 42 -2.05572501506252 0.0237165266173161 -2.86359716117504 -3.08275229584023 0.219155134665185 0.965360495544115 1.7092604871001 0.133242731936201 0.2270189589037 0.128216346378544 0.761516852000491 NA NA NA 0.653651341814522 99.727107917785 a8839 loss_cnaBRCA28_(GPS2) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 40 1.6094379124341 NA 2.84211934322079 2.54673305176886 0.295386291451928 0.61948913711126 1.65014108527556 0.182879525939145 0.476822390832136 0.179006688632688 0.761525625011318 NA NA NA 0.536447178257959 99.727107917785 a8840 gain_cnaBRCA8_(CHD4,WNK1) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 42 2.30258509299405 NA 2.95377069194079 3.19280242723841 -0.239031735297621 0.470958576210662 1.33901861957202 0.182265646108046 0.507543014124243 0.17851262992446 0.761846115518234 NA NA NA 0.515809402611323 99.727107917785 a8841 gain_cnaBRCA62 86 A-443654 AKT1, AKT2, AKT3 4 8 0.0237165266173161 NA -1.11114034706899 -1.35712423197868 0.24598388490969 0.707947689262386 1.47028200639664 0.190715703865875 0.347460537890846 0.167303880370913 0.761863811493286 NA NA NA 0.703912930108515 99.727107917785 a8842 NF1_mut 299 OSI-027 MTORC1/2 4 44 2.99573227355399 NA 0.977431381106412 1.29547303476899 -0.31804165366258 1.10745696715157 2.04565238478691 0.15918476297059 0.28718195207223 0.155471993202652 0.761881484161942 NA NA NA 0.636664482939866 99.727107917785 a8843 MACF1_mut 1194 SB-505124 TGFR1 (ALK5) 3 44 2.30258509299405 NA 4.54615119082736 4.37828417322807 0.167867017599293 0.883807532500945 0.926072390163585 0.181628069337587 0.189936169840364 0.181267705831982 0.76223900015999 NA NA NA 0.77743376619585 99.727107917785 a8844 gain_cnaBRCA16 173 FH535 unknown 16 32 3.46573590279973 NA 1.65296172563771 1.53301624247705 0.119945483160667 1.65152123251124 1.06960420113385 0.0930844847340068 0.0726272728436451 0.112140063617474 0.762489247740131 NA NA NA 0.794196276775605 99.727107917785 a8845 gain_cnaBRCA27_(CLTC,PPM1D) 203 BMS-345541 IKBKB 9 40 2.77258872223978 NA 3.43950629747828 3.55321796122821 -0.113711663749932 1.11229807237679 0.993484769261726 0.112065282488964 0.102231287254638 0.114457379990267 0.762654784744091 NA NA NA 0.782857287651859 99.727107917785 a8846 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1007 Docetaxel Microtubules 5 40 -4.38202663467388 NA -4.38812821544036 -4.612173585538 0.224045370097637 1.652882006334 1.54379739753853 0.144148498420616 0.13554831454337 0.145126148324166 0.762676094425408 NA NA NA 0.78523542382038 99.727107917785 a8847 gain_cnaBRCA13_(FGFR1,WHSC1L1) 186 Bexarotene Retinioic acid X family agonist 10 37 2.07944154167984 NA 3.70224299220778 3.57796288655909 0.124280105648688 1.42416145918508 1.06758018776692 0.108277440549701 0.0872654605607726 0.116412900007678 0.762679444298498 NA NA NA 0.801486055727119 99.727107917785 a8848 ARID1A_mut 345 KIN001-270 CDK9 5 44 2.99573227355399 NA 5.19700295180835 5.09742608321851 0.0995768685898453 0.629632722383149 0.700497709868039 0.143328015772411 0.158150720332559 0.142151597624215 0.762697100498929 NA NA NA 0.753498765601815 99.727107917785 a8849 loss_cnaBRCA60 164 JQ12 HDAC 3 44 1.63315443905142 NA 1.29749636541262 1.5970004535277 -0.299504088115077 0.845554233329578 1.68060122420794 0.181245988266735 0.354210382148649 0.178212465753874 0.762723640706898 NA NA NA 0.621618647590625 99.727107917785 a8850 CDH1_mut 152 CP466722 ATM 4 45 2.77258872223978 NA 2.88551779878039 2.71633055729029 0.169187241490096 0.440190731670764 1.097985769436 0.158389647826696 0.384349849548032 0.154088737941479 0.762792063954296 NA NA NA 0.556633688956339 99.727107917785 a8851 POLR2B_mut 288 KIN001-055 JAK3, MNK1 3 46 2.32630161961136 NA 4.48515764646821 4.3294754250485 0.155682221419703 0.260189900024458 0.877963179177421 0.180867036085219 0.59834075575212 0.177322039365665 0.762825978975098 NA NA NA 0.462619201004743 99.727107917785 a8852 gain_cnaBRCA31 63 BMS-509744 ITK 3 9 2.32630161961136 NA 3.76915577940619 3.53850187717603 0.230653902230164 1.10589484876734 1.11803177413863 0.206750457910349 0.20856766128105 0.206303530512689 0.762832073587461 NA NA NA 0.772761972761083 99.727107917785 a8853 gain_cnaBRCA8_(CHD4,WNK1) 266 Zibotentan, ZD4054 Endothelin A Receptor 4 45 2.99573227355399 NA 5.81407316519274 5.73563638177501 0.0784367834177262 0.586703419135257 0.48879913551283 0.158257845573978 0.133690687423186 0.160468334984744 0.762983353258299 NA NA NA 0.810267733364619 99.727107917785 a8854 gain_cnaBRCA8_(CHD4,WNK1) 1046 681640 WEE1, CHEK1 3 33 0.693147180559945 NA 2.81457503253304 2.61736032460712 0.197214707925913 0.84933893140664 1.08849226607756 0.183302594866894 0.232197890186541 0.181181542645762 0.763001085237423 NA NA NA 0.735643938573023 99.727107917785 a8855 gain_cnaBRCA9_(KRAS) 173 FH535 unknown 4 44 3.46573590279973 NA 1.38595053484399 1.59000239159302 -0.20405185674903 1.55648318096325 1.2677700114611 0.158354971819356 0.131098015863396 0.160953370804111 0.763084296870019 NA NA NA 0.813763362765788 99.727107917785 a8856 ARID1A_mut 1133 JNJ-26854165 MDM2 5 38 2.30258509299405 NA 2.85676094834232 2.98355983775622 -0.126798889413899 1.26652421719964 0.826026901448277 0.14429022073257 0.100115645395442 0.153504551960211 0.763191253049727 NA NA NA 0.837157417555584 99.727107917785 a8857 loss_cnaBRCA34 1199 Tamoxifen ER 5 42 1.6094379124341 NA 3.7462148724466 3.88380776394176 -0.137592891495163 0.523464863624943 0.991850626590703 0.143397631313708 0.262850290547383 0.13872340028469 0.76320163989191 NA NA NA 0.635957753586597 99.727107917785 a8858 TP53_mut 279 BIX02189 MAP2K5 (MEK5) 38 11 2.99573227355399 NA 5.00626167118302 5.10022751616021 -0.093965844977193 0.938765994152063 0.771689721563009 0.103737681012927 0.100095066888386 0.121766355507329 0.763235416287924 NA NA NA 0.73905335560111 99.727107917785 a8859 loss_cnaBRCA38 1378 Bleomycin (50 uM) DNA damage 4 44 3.91202300542815 NA 3.53738975056912 3.83774741886169 -0.300357668292567 1.77723518966975 1.90658852580543 0.158214457860915 0.169002769041716 0.15753670192979 0.763288035603746 NA NA NA 0.76528323593603 99.727107917785 a8860 MACF1_mut 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 3 43 2.30258509299405 NA 1.24372513013999 1.42499699331864 -0.181271863178647 0.701266903951054 1.01410081499122 0.18090964588912 0.25849196954445 0.178751323831858 0.763352150454293 NA NA NA 0.707599046935015 99.727107917785 a8861 gain_cnaBRCA9_(KRAS) 1039 SL 0101-1 RSK, AURKB, PIM3 4 39 2.30258509299405 NA 4.78891084708645 4.63446092449627 0.154449922590177 0.316086097661037 1.00510326951183 0.158996764914709 0.488632444555678 0.153665724980869 0.763541385866713 NA NA NA 0.507118794967725 99.727107917785 a8862 TP53_mut 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 34 9 1.6094379124341 NA 2.52896781624604 2.7123082608946 -0.183340444648555 1.31969797855869 2.48733274421464 0.113507437035908 0.138926063104825 0.0737096574935508 0.763575974269654 NA NA NA 0.835714852340721 99.727107917785 a8863 PTEN_mut 1241 CHIR-99021 GSK3B 8 38 2.30258509299405 NA 4.13583053095035 4.25162531596833 -0.11579478501798 0.69394167380841 1.0301717182168 0.117630683310059 0.166865299186441 0.112403381854064 0.763773827189481 NA NA NA 0.702185217011207 99.727107917785 a8864 gain_cnaBRCA14_(RAD21) 286 KIN001-236 TIE2 21 28 2.32630161961136 NA 4.50162910814369 4.56896015305446 -0.0673310449107731 0.816258295023742 0.737457628080258 0.0872193602070584 0.0824874250237355 0.0913015776730774 0.763880843320871 NA NA NA 0.767440945629366 99.727107917785 a8865 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1241 CHIR-99021 GSK3B 18 28 2.30258509299405 NA 4.17678951027021 4.26664982391198 -0.0898603136417702 1.16297641630304 0.852983305183387 0.0912848776272475 0.0772675287151783 0.105348267774655 0.763954754925558 NA NA NA 0.779532461751307 99.727107917785 a8866 MLL3_mut 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 3 23 2.30258509299405 NA 4.52010614780717 4.70740293924672 -0.187296791439548 0.952273391763962 1.0101559566729 0.186279761849442 0.196683844218944 0.185413737554385 0.764153321052978 NA NA NA 0.773987615703249 99.727107917785 a8867 gain_cnaBRCA47_(EGFR) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 7 40 2.32630161961136 NA 1.25453269816497 1.44535690221223 -0.190824204047267 0.882553415495527 1.62091510020404 0.123669482008061 0.216218305540322 0.117726217753938 0.764156296451715 NA NA NA 0.656855722270258 99.727107917785 a8868 loss_cnaBRCA38 179 5-Fluorouracil DNA antimetabolite 4 45 3.46573590279973 NA 3.80616944348409 4.06239288757128 -0.256223444087191 1.41789728731907 1.64207904292687 0.157318558591448 0.180706632545756 0.156035999113961 0.764347005875954 NA NA NA 0.750892170983261 99.727107917785 a8869 BRCA1_mut 178 BAY 61-3606 SYK 4 44 2.07944154167984 NA 3.32910902769691 3.07453862111157 0.254570406585339 0.983501232526539 1.65228935075267 0.157421523803418 0.258840963453973 0.154071323203393 0.764438070318899 NA NA NA 0.664732435673261 99.727107917785 a8870 gain_cnaBRCA30_(CRNKL1,FOXA2) 275 I-BET BRD2, BRD3, BRD4 5 44 2.99573227355399 NA 4.21326559825197 4.01913145263631 0.194134145615667 1.93685351771311 1.30258084679304 0.141904872596265 0.100231712847797 0.149038077823442 0.764981435305199 NA NA NA 0.836704501425416 99.727107917785 a8871 TP53_mut 163 JQ1 BRD4 37 10 0.940007258491471 NA 0.282435014731565 0.439799145039424 -0.157364130307859 1.460663958744 1.49733279006881 0.107191089838436 0.10773465680852 0.105096296128417 0.764987721102659 NA NA NA 0.771274091805168 99.727107917785 a8872 loss_cnaBRCA38 1375 Temozolomide DNA akylating agent 3 43 3.40119738166216 NA 5.7821617575638 5.9083559943365 -0.126194236772696 0.504151746675402 0.710943731765399 0.17954257936751 0.250310025909611 0.177502425486379 0.765085833785735 NA NA NA 0.715714737785786 99.727107917785 a8873 gain_cnaBRCA14_(RAD21) 178 BAY 61-3606 SYK 21 27 2.07944154167984 NA 3.01623512973901 3.15759991537695 -0.141364785637942 1.72207963800282 1.5315251822058 0.0874167419940563 0.0820895750221456 0.0923032721109679 0.765191156217348 NA NA NA 0.768747725369548 99.727107917785 a8874 loss_cnaBRCA60 226 GSK1070916 AURKB 3 46 0.940007258491471 2.32630161961136 2.73293898820721 2.38249175623112 0.350447231976088 0.662606403887736 1.99865733928279 0.178759368631619 0.528892008770056 0.175341327944612 0.765505758163654 NA NA NA 0.500547116481316 99.727107917785 a8875 loss_cnaBRCA17 290 KIN001-260 IKK 11 38 2.99573227355399 NA 4.9605446031994 5.06825309158879 -0.107708488389388 0.680852875235643 1.12764963674448 0.102711339225664 0.158196421439963 0.0955159163624104 0.765506712458118 NA NA NA 0.69828467277786 99.727107917785 a8876 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 104 Bortezomib Proteasome 4 10 -3.91202300542815 NA -4.80537819623307 -4.47844900067327 -0.326929195559805 2.02980558695929 1.73337412990343 0.180421119082442 0.161064289930128 0.188608558256271 0.765615724515489 NA NA NA 0.788504228000313 99.727107917785 a8877 gain_cnaBRCA64_(SDHC) 151 QS11 ARFGAP 8 40 2.32630161961136 NA 3.61623438929116 3.78929299344848 -0.173058604157314 1.68014951330227 1.45393820085393 0.116101684911676 0.10300190714407 0.11902748277449 0.765700559057398 NA NA NA 0.791843156906286 99.727107917785 a8878 gain_cnaBRCA64_(SDHC) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 9 36 0.693147180559945 NA 0.754783389796299 0.593265305495557 0.161518084300742 1.27825380502532 1.48151112971427 0.11171066343604 0.12635838333964 0.109022525083489 0.765811209319352 NA NA NA 0.747807473946102 99.727107917785 a8879 gain_cnaBRCA58_(CCND1) 1001 AICAR AAPK1 (AMPK) agonist 9 36 7.60090245954208 NA 7.61428065259045 7.76953395647704 -0.155253303886588 1.19092437350948 1.43223189829162 0.111651912345841 0.130363696755219 0.108399557412299 0.765930653286505 NA NA NA 0.742333892700316 99.727107917785 a8880 gain_cnaBRCA31 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 16 32 2.07944154167984 NA 3.28572853993779 3.1785909062555 0.107137633682283 1.39423763964248 1.04226054387565 0.0916692380674275 0.0768431654949123 0.102793523473403 0.765990720815586 NA NA NA 0.788176208110413 99.727107917785 a8881 BRCA2_mut 224 AS605240 PI3Kgamma 6 43 2.99573227355399 2.32630161961136 3.45234846196276 3.24484860337425 0.20749985858851 1.4915931929392 1.60231843628105 0.130428776777799 0.139112902613634 0.12949976352398 0.766041937245792 NA NA NA 0.761413638046317 99.727107917785 a8882 gain_cnaBRCA61_(NOTCH2) 224 AS605240 PI3Kgamma 3 46 2.99573227355399 2.32630161961136 3.00393240952927 3.28762572800612 -0.283693318476847 0.507545623592111 1.62235021879365 0.178321886229383 0.558951363759244 0.174865645648198 0.766062356604212 NA NA NA 0.484388719845884 99.727107917785 a8883 TP53_mut 1 Erlotinib EGFR 8 4 0.693147180559945 NA 2.88994519550662 2.99982739267655 -0.109882197169932 0.655285452215581 0.384690460304072 0.187082561711054 0.167686001266181 0.285637957029342 0.766246548716734 NA NA NA 0.723188893714849 99.727107917785 a8884 loss_cnaBRCA42 298 OSI-930 KIT, VEGFR, PDGFR 3 45 2.32630161961136 NA 4.06039190663046 3.90356565576301 0.15682625086745 1.05118718711378 0.871046381737486 0.178283361633875 0.149189652223639 0.180043513359905 0.766294114136528 NA NA NA 0.82230278448725 99.727107917785 a8885 BRCA1_mut 1018 ABT-888 PARP1, PARP2 4 41 1.6094379124341 NA 4.30758098805932 4.41239279728658 -0.104811809227261 0.539769764306037 0.677778922066853 0.156651863739701 0.194178733523568 0.154640113191544 0.766338631917014 NA NA NA 0.736038543962471 99.727107917785 a8886 TP53_mut 269 NSC-207895 MDM4 38 11 2.99573227355399 NA 4.6313695280308 4.50919413728035 0.122175390750454 1.20727232030172 1.15152047851344 0.102185122971599 0.101199529464835 0.106099190618109 0.766672038878905 NA NA NA 0.762970239444484 99.727107917785 a8887 loss_cnaBRCA18 71 Pyrimethamine Dihydrofolate reductase (DHFR) 6 8 2.99573227355399 NA 4.4732353258978 4.64179723009149 -0.168561904193697 0.974286279843233 1.06791854295434 0.163661854800754 0.173010651675008 0.157841536984066 0.76704645920866 NA NA NA 0.764093419072905 99.727107917785 a8888 NF1_mut 204 Tipifarnib Farnesyl-transferase (FNTA) 5 43 2.77258872223978 NA 1.81219947600578 1.59762502186127 0.214574454144507 1.12306441659693 1.55688647066795 0.140790159447572 0.191061573115017 0.13782280094736 0.767068630496308 NA NA NA 0.712729026120454 99.727107917785 a8889 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 6 41 2.99573227355399 NA 4.01092333099256 3.8237705104226 0.187152820569963 1.56596908899363 1.42033211179526 0.130216551558072 0.119512461571152 0.131766943108403 0.767143142833816 NA NA NA 0.791009484700214 99.727107917785 a8890 gain_cnaBRCA19 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 3 40 1.6094379124341 NA 2.62940635387894 2.88585040015356 -0.256444046274626 1.14447403222957 1.45126769823663 0.178355943678092 0.224071528975667 0.176703475579467 0.767245693811791 NA NA NA 0.742571684351169 99.727107917785 a8891 loss_cnaBRCA22_(SYNCRIP,ZNF292) 135 Gemcitabine DNA replication 17 30 0.0237165266173161 NA -0.435720604443442 -0.184275500733075 -0.251445103710367 2.90424588811575 2.71231112379093 0.0903805141342168 0.0865784487254632 0.0927051109678482 0.767285550165237 NA NA NA 0.772181468988946 99.727107917785 a8892 gain_cnaBRCA19 1495 AZD-2281 PARP1, PARP2 4 41 2.30258509299405 NA 3.83699102073481 4.01446693365976 -0.177475912924955 0.660978552057148 1.16580939687322 0.155970688047498 0.26850479848794 0.152234073083436 0.767324286855456 NA NA NA 0.657668791271916 99.727107917785 a8893 gain_cnaBRCA12_(TERT) 306 TG101348 JAK2 9 39 2.32630161961136 NA 3.10946978888789 3.25152411845002 -0.14205432956213 1.27841993981803 1.29440343107362 0.109979994704055 0.111117110377948 0.109745019328561 0.767497165035204 NA NA NA 0.769441920302309 99.727107917785 a8894 MLL3_mut 1023 GW 441756 NTRK1 3 42 0.693147180559945 NA 2.57676619441864 2.34375254778586 0.233013646632782 1.15941752025947 1.3178319250777 0.177752470060398 0.200974750304477 0.176815906640783 0.767565339976006 NA NA NA 0.766135314434224 99.727107917785 a8895 gain_cnaBRCA58_(CCND1) 1199 Tamoxifen ER 9 38 1.6094379124341 NA 3.95468954669807 3.84891564546064 0.105773901237435 0.70764780775231 1.00576164868679 0.110232041202919 0.149472520198151 0.105167960396524 0.767565600610736 NA NA NA 0.71692636643789 99.727107917785 a8896 POLR2B_mut 197 Bryostatin 1 PRKC 3 45 -4.8283137373023 NA -2.64512925572702 -2.81758223424813 0.172452978521111 1.44057021814127 0.946076563074975 0.177271738409263 0.119711608881948 0.182282264725592 0.767580710902178 NA NA NA 0.85600492370389 99.727107917785 a8897 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1091 BMS-536924 IGF1R 9 38 1.38629436111989 NA 2.92514768924235 3.04654934470945 -0.1214016554671 0.985590443659096 1.12544374166266 0.110176936991188 0.123176575268308 0.107870034700934 0.767678340848196 NA NA NA 0.75166691725653 99.727107917785 a8898 gain_cnaBRCA13_(FGFR1,WHSC1L1) 111 Salubrinal GADD34-PP1C 3 10 2.77258872223978 NA 3.41223543758161 3.18433620853825 0.227899229043361 1.76101593921027 0.953282914463684 0.1993165264176 0.129413495908256 0.239067778920151 0.767703785690932 NA NA NA 0.846999297854153 99.727107917785 a8899 loss_cnaBRCA7_(FAS,PTEN) 203 BMS-345541 IKBKB 4 45 2.77258872223978 NA 3.67670110622669 3.51949934892281 0.157201757303887 0.795622106759946 1.02797570391351 0.154918950134197 0.197583445668784 0.152923611623718 0.767834163935089 NA NA NA 0.731222194522428 99.727107917785 a8900 gain_cnaBRCA58_(CCND1) 152 CP466722 ATM 10 39 2.77258872223978 NA 2.81961818722271 2.70719908720404 0.112419100018676 1.11261004935021 1.05742931228317 0.105239994327099 0.101040881380077 0.106313584003023 0.767848521492018 NA NA NA 0.777792398095078 99.727107917785 a8901 loss_cnaBRCA34 303 PIK-93 PI4K, PI3K 5 44 2.99573227355399 NA 2.97157014304534 2.77106777428375 0.200502368761583 0.468977903192129 1.48937986378405 0.140099021264178 0.427530524139518 0.134621377418228 0.767883105954144 NA NA NA 0.523067178644254 99.727107917785 a8902 BRCA2_mut 208 SB-715992 KIF11 6 43 -2.05572501506252 NA -1.43500990772828 -1.21267454531198 -0.222335362416301 1.4922883746061 1.74416089586104 0.129330845690349 0.148989542637822 0.127474112591282 0.767952838873093 NA NA NA 0.747751502534274 99.727107917785 a8903 gain_cnaBRCA48 1053 MK-2206 AKT1, AKT2 4 38 1.38629436111989 0.693147180559945 1.62794646589626 1.36924037778681 0.258706088109453 1.09718461021345 1.6946139232869 0.156101497460422 0.235790846591554 0.152663733346214 0.768030461146232 NA NA NA 0.692000475453092 99.727107917785 a8904 gain_cnaBRCA15 184 BMS-754807 IGF1R 22 26 0.940007258491471 NA 1.70552947262313 1.56031005488174 0.145219417741394 1.8604299802075 1.53168151923336 0.0859431072877446 0.0780569111906043 0.0948104523805185 0.768046222791972 NA NA NA 0.771869670882567 99.727107917785 a8905 gain_cnaBRCA48 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 4 39 0.693147180559945 NA 2.77235515162425 2.92237392858186 -0.150018776957611 0.819433771101869 0.973319169090338 0.155799961691861 0.183076146295369 0.154131123398935 0.768153122531213 NA NA NA 0.749719407024425 99.727107917785 a8906 loss_cnaBRCA24 1495 AZD-2281 PARP1, PARP2 3 42 2.30258509299405 NA 4.18695603698605 3.98524381552455 0.201712221461499 0.293175123612262 1.16351132087432 0.177268840884394 0.688026388378958 0.173365069890272 0.768178992987746 NA NA NA 0.43594454331966 99.727107917785 a8907 loss_cnaBRCA29_(MAP2K4) 1016 Temsirolimus MTOR 6 38 -1.6094379124341 NA -1.92041919085626 -1.72418123831408 -0.196237952542178 1.52456817066312 1.50728134932424 0.130014902655037 0.128717073016698 0.130193313033534 0.768718449889551 NA NA NA 0.778129364675334 99.727107917785 a8908 CDH1_mut 1375 Temozolomide DNA akylating agent 5 41 3.40119738166216 NA 5.81237261358649 5.91082756002996 -0.0984549464434705 0.954298112816806 0.672599071493359 0.140071858129551 0.10317001062997 0.146379842935068 0.768851496297357 NA NA NA 0.832564202793272 99.727107917785 a8909 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 6 41 -2.30258509299405 NA -0.258312604284247 -0.123380431046181 -0.134932173238066 1.16275469462029 1.02842055129889 0.129220579865332 0.116045262050849 0.131203303033616 0.76887161505453 NA NA NA 0.796469198428033 99.727107917785 a8910 ARID1A_mut 1023 GW 441756 NTRK1 5 40 0.693147180559945 NA 2.19593034959376 2.37970634605733 -0.183775996463571 0.651355274933538 1.36059268318101 0.140190125933035 0.282144021144717 0.135070545899093 0.76899875761576 NA NA NA 0.623660036953793 99.727107917785 a8911 gain_cnaBRCA58_(CCND1) 193 GW-2580 CSF1R (cFMS) 10 38 2.99573227355399 NA 5.52571858268908 5.44698631090652 0.0787322717825667 0.535545001475289 0.794291355020984 0.104876033294215 0.147013363145356 0.0991226598210762 0.769256578291137 NA NA NA 0.715144737998399 99.727107917785 a8912 loss_cnaBRCA24 222 BX-912 PDPK1 (PDK1) 3 46 2.32630161961136 NA 3.63268592264312 3.90015653142807 -0.267470608784953 0.528231002123802 1.55102182776702 0.175786009709104 0.50635159184062 0.172447997827359 0.769291138901431 NA NA NA 0.515344086687018 99.727107917785 a8913 loss_cnaBRCA17 1018 ABT-888 PARP1, PARP2 8 37 1.6094379124341 NA 4.33979242148351 4.41675916943565 -0.0769667479521425 0.636706828945811 0.675210376956386 0.115031402223619 0.120882554502479 0.113989284790145 0.769396036473926 NA NA NA 0.764995768168658 99.727107917785 a8914 gain_cnaBRCA48 134 Etoposide TOP2 5 42 2.77258872223978 NA 2.7480200259884 2.44484951488482 0.303170511103582 1.96866624560086 2.19268851024778 0.139471427703831 0.153997922086103 0.138264285915067 0.769492934433705 NA NA NA 0.760271285405564 99.727107917785 a8915 gain_cnaBRCA8_(CHD4,WNK1) 151 QS11 ARFGAP 3 45 2.32630161961136 NA 4.00605914710063 3.74407594246592 0.261983204634711 2.21530320175793 1.44910098237508 0.175753790402478 0.118260653632792 0.180790164261237 0.769512499423535 NA NA NA 0.857707306433915 99.727107917785 a8916 BRCA2_mut 1261 rTRAIL TR10A (DR4), TR10B (DR5) 5 42 -2.30258509299405 NA -0.270723996407164 -0.125115555156263 -0.145608441250901 1.09155076857818 1.03947191518242 0.139444128107849 0.133395940383575 0.140079245166857 0.769536734441854 NA NA NA 0.788457993968517 99.727107917785 a8917 loss_cnaBRCA34 222 BX-912 PDPK1 (PDK1) 5 44 2.32630161961136 NA 4.07367890026717 3.86220144800647 0.2114774522607 1.16875306106361 1.55031803714808 0.138985963829858 0.180942800755746 0.13640907684318 0.769673261471677 NA NA NA 0.725107053037205 99.727107917785 a8918 loss_cnaBRCA28_(GPS2) 231 FMK RSK 4 45 2.99573227355399 2.32630161961136 5.504954637332 5.5967208138151 -0.0917661764830964 0.571547775791299 0.598977406958531 0.15364418909877 0.160557315363615 0.153204737636206 0.769688651719917 NA NA NA 0.77606564608527 99.727107917785 a8919 TP53_mut 1066 AZD6482 PI3Kbeta 34 9 1.6094379124341 NA 1.9336929919286 2.0937229675053 -0.160029975576695 1.44695472594766 1.45817649084342 0.110430146796135 0.110597776631806 0.109746643552134 0.7697955656407 NA NA NA 0.774151071086929 99.727107917785 a8920 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 262 VX-11e ERK 7 42 1.63315443905142 NA 3.91471394182771 3.75382827839939 0.160885663428311 1.21705865846392 1.35625173644369 0.120127742730968 0.132192201509309 0.118625222077267 0.769861279424776 NA NA NA 0.757739075635254 99.727107917785 a8921 loss_cnaBRCA34 157 JNK-9L JNK 5 42 1.63315443905142 NA -0.0763179281974896 0.071577896162146 -0.147895824359636 0.5203555225406 1.10163569958339 0.139141372685819 0.284220725932809 0.134251118056147 0.770022532115223 NA NA NA 0.619966952242161 99.727107917785 a8922 gain_cnaBRCA61_(NOTCH2) 303 PIK-93 PI4K, PI3K 3 46 2.99573227355399 NA 3.02681096566722 2.77618260623283 0.250628359434393 1.21023050186032 1.44020744240022 0.175120790716913 0.207091425186472 0.174022402645483 0.770138809876842 NA NA NA 0.759392930001607 99.727107917785 a8923 BRCA2_mut 1375 Temozolomide DNA akylating agent 5 41 3.40119738166216 NA 5.81288050520236 5.91076562202803 -0.0978851168256636 0.374427065104885 0.727633769153133 0.139259564455828 0.261426392342241 0.134525252916159 0.770152854597411 NA NA NA 0.641021266188125 99.727107917785 a8924 gain_cnaBRCA16 127 GSK269962A ROCK1, ROCK2 3 11 0.916290731874155 NA 2.29451681593551 2.51540882264517 -0.220892006709658 0.670000886766485 1.20697635232813 0.194574324132644 0.329689125899091 0.18301270466781 0.770256245421241 NA NA NA 0.691610732299521 99.727107917785 a8925 gain_cnaBRCA9_(KRAS) 287 KIN001-244 PDPK1 (PDK1) 4 45 2.99573227355399 NA 3.61165701907241 3.4662348438825 0.14542217518991 0.584736130314326 0.968755147135297 0.153253733576798 0.24869709198872 0.150112415526191 0.770256948507617 NA NA NA 0.675728416624663 99.727107917785 a8926 gain_cnaBRCA10_(MDM2,NUP107) 1019 Bosutinib SRC, ABL, TEC 3 42 0.693147180559945 NA 2.81677450287275 2.65158596834121 0.16518853453154 0.17262996056379 0.962647788441901 0.175595914605333 0.956893774360214 0.171598103184662 0.77030284386699 NA NA NA 0.368896194960603 99.727107917785 a8927 loss_cnaBRCA22_(SYNCRIP,ZNF292) 281 CH5424802 ALK 18 30 1.63315443905142 NA 3.51657668017116 3.610437393573 -0.093860713401837 1.35448089378645 0.864614090644316 0.0875523141424256 0.0692964469505724 0.108557927076913 0.770339095719524 NA NA NA 0.794254761589668 99.727107917785 a8928 gain_cnaBRCA27_(CLTC,PPM1D) 170 Shikonin unknown 9 38 2.77258872223978 NA 0.108763366512311 -0.0212972095896939 0.130060576102005 0.96007761288803 1.23962560144412 0.10886295551527 0.135468814558405 0.104919240091919 0.770368175938708 NA NA NA 0.73552199880868 99.727107917785 a8929 BRCA2_mut 192 LFM-A13 BTK 6 42 2.77258872223978 NA 4.88991334595031 4.78197823544939 0.107935110500917 0.670603438016615 0.860935199318985 0.128138317102387 0.160952217632745 0.125369610379847 0.770382852335606 NA NA NA 0.732480129630069 99.727107917785 a8930 gain_cnaBRCA48 341 EX-527 SIRT1 5 44 2.99573227355399 NA 5.72370218769029 5.63244085823559 0.0912613294547038 0.368912373998004 0.679523853020302 0.138523449296095 0.24737942093316 0.134301877776728 0.770417507522311 NA NA NA 0.651633307067633 99.727107917785 a8931 NF1_mut 1218 JQ1 BRD2, BRD3, BRD4 5 41 0 NA 2.54559547650821 2.44729728609257 0.098298190415635 0.279555024991948 0.736156693601895 0.139047278751187 0.351623765011795 0.133528895777172 0.770493063520661 NA NA NA 0.572869008061898 99.727107917785 a8932 gain_cnaBRCA47_(EGFR) 206 Ruxolitinib JAK1, JAK2, TYK2 7 42 1.65632149833295 0.0237165266173161 4.4377554844467 4.35901128031161 0.0787442041350923 0.519370506199575 0.675540367103216 0.119731741303926 0.151614701249196 0.116564764993623 0.770597964370281 NA NA NA 0.73067006164181 99.727107917785 a8933 loss_cnaBRCA28_(GPS2) 194 AUY922 HSP90 4 43 -1.36257783450257 NA -2.63776622671292 -2.3710476188222 -0.266718607890718 0.928842617058717 1.78314861454584 0.15334833763853 0.287151561515676 0.149577329514203 0.770599038383386 NA NA NA 0.639814883208345 99.727107917785 a8934 loss_cnaBRCA7_(FAS,PTEN) 133 Doxorubicin DNA intercalating 4 44 0.0237165266173161 NA -0.771255244230412 -1.05422586892517 0.282970624694761 1.80979423463888 1.84991671720894 0.153178449984338 0.156355136555745 0.152963980519995 0.770601089959929 NA NA NA 0.78152894609412 99.727107917785 a8935 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1243 piperlongumine Increases ROS levels 6 41 2.30258509299405 NA 1.80634831452267 1.69618359094518 0.110164723577496 0.467696671380029 0.896357167589666 0.128194947173706 0.235547375722032 0.122902708385467 0.77065280468231 NA NA NA 0.650466197805768 99.727107917785 a8936 loss_cnaBRCA33 164 JQ12 HDAC 6 41 1.63315443905142 NA 1.76265622358257 1.55084321243808 0.211813011144496 0.812652511750163 1.7291261577738 0.128170492657432 0.260644012147735 0.122497141224906 0.770695289511342 NA NA NA 0.628694180166093 99.727107917785 a8937 gain_cnaBRCA47_(EGFR) 1054 PD-0332991 CDK4, CDK6 6 36 1.38629436111989 0.693147180559945 2.71921097522581 2.91018703216404 -0.190976056938235 1.65343464370933 1.44974314200084 0.129322572233969 0.115502634267901 0.131730960751201 0.770827396406409 NA NA NA 0.798394943188447 99.727107917785 a8938 gain_cnaBRCA31 1149 TW 37 BCL2, BCL2L1 13 30 1.6094379124341 NA -0.0570718731870647 -0.179352935593622 0.122281062406558 1.04054306998722 1.33546105456054 0.0973319448118491 0.11751657949926 0.0915646787219837 0.7709048425551 NA NA NA 0.748507145436862 99.727107917785 a8939 loss_cnaBRCA28_(GPS2) 1494 SN-38 TOP1 4 44 -2.99573227355399 NA -3.54125485633645 -3.28220066024969 -0.259054196086755 1.19104167440291 1.72436754165594 0.152860558516135 0.217502209749817 0.150231426786183 0.771063432494031 NA NA NA 0.70939416917648 99.727107917785 a8940 loss_cnaBRCA18 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 16 32 2.07944154167984 NA 3.28405202779131 3.17942916232874 0.104622865462573 1.07827139838145 1.21016713580594 0.0895135028942748 0.0970283229432014 0.0864532363894481 0.771333721428555 NA NA NA 0.76300302549531 99.727107917785 a8941 loss_cnaBRCA20 299 OSI-027 MTORC1/2 3 45 2.99573227355399 NA 0.942428176157582 1.29073898946197 -0.348310813304385 2.03826133244419 1.99625708828416 0.174320861445436 0.170886239050959 0.17448194190447 0.77133744706975 NA NA NA 0.798322484924942 99.727107917785 a8942 gain_cnaBRCA30_(CRNKL1,FOXA2) 262 VX-11e ERK 5 44 1.63315443905142 NA 3.61093243442677 3.7956618889417 -0.184729454514927 1.76239375306883 1.2929282107926 0.137929363687373 0.104817356616965 0.142876807059289 0.771373788700764 NA NA NA 0.829980660990321 99.727107917785 a8943 loss_cnaBRCA20 276 CAY10603 HDAC6 3 46 2.99573227355399 NA 1.3387295872554 1.16489692961925 0.173832657636142 0.598712384761195 1.01235182057137 0.174137772697393 0.290344182049078 0.171711705460293 0.771391962568352 NA NA NA 0.677669823080874 99.727107917785 a8944 gain_cnaBRCA16 1069 EHT 1864 Rac GTPases 16 30 2.30258509299405 NA 3.61244433214836 3.53420961838366 0.0782347137647075 0.913149299117732 0.838596881868747 0.0904724858242045 0.0856757091532529 0.09329239764208 0.771467245022939 NA NA NA 0.777991248007788 99.727107917785 a8945 gain_cnaBRCA19 150 Bicalutamide ANDR (androgen receptor) 4 44 0.0237165266173161 NA 2.85036865017016 2.75460766102384 0.0957609891463198 0.650058683983109 0.626004891284195 0.152582420136426 0.147311298973137 0.152971630860383 0.771468026910078 NA NA NA 0.79304556199902 99.727107917785 a8946 NF1_mut 178 BAY 61-3606 SYK 5 43 2.07944154167984 NA 3.29565642682156 3.07250821640905 0.223148210412507 1.45767290412672 1.63160561265195 0.137982269477169 0.153085242773442 0.136766022795062 0.771579586249539 NA NA NA 0.761476473189512 99.727107917785 a8947 loss_cnaBRCA17 64 CMK RSK 3 9 1.38629436111989 NA 2.01923309127332 2.26579760415292 -0.246564512879601 1.27958683983565 1.23069513520321 0.198741755802243 0.192690722664254 0.200345728057898 0.771719193434032 NA NA NA 0.787633062769694 99.727107917785 a8948 loss_cnaBRCA29_(MAP2K4) 1004 Vinblastine Microtubules 6 39 -2.30258509299405 NA -3.3122282486175 -3.47761144903994 0.165383200422434 1.45625076682579 1.26931243089532 0.127962051997604 0.113567803148988 0.130293532464486 0.771843956782967 NA NA NA 0.800872865856767 99.727107917785 a8949 gain_cnaBRCA14_(RAD21) 330 XMD13-2 RIPK 21 27 2.32630161961136 NA 3.66260921394089 3.76645282351434 -0.103843609573445 1.31783146587748 1.14784926097382 0.0847940345005457 0.0787988542254908 0.0904679848688011 0.772031639068834 NA NA NA 0.776080292564197 99.727107917785 a8950 loss_cnaBRCA38 172 Embelin XIAP 4 44 3.46573590279973 NA 2.85717918976966 3.00541517888996 -0.1482359891203 0.730348455746569 0.989020768216044 0.152154484578437 0.202966115631438 0.149881573657632 0.772090649382968 NA NA NA 0.72580020411666 99.727107917785 a8951 gain_cnaBRCA15 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 22 26 2.07944154167984 NA 3.16090104109436 3.25949010519634 -0.0985890641019811 1.18646636562161 1.15375656752239 0.0843504639057698 0.0830946978006648 0.0854504900576156 0.772220919883117 NA NA NA 0.77279837112041 99.727107917785 a8952 PIK3CA_mut 1025 SB 216763 GSK3A, GSK3B 16 23 2.30258509299405 NA 4.93355574713382 4.85827826271261 0.0752774844212096 1.03641153858196 0.570833018015574 0.0948998878267491 0.072632811985291 0.131873038253642 0.772287453461528 NA NA NA 0.794306148561551 99.727107917785 a8953 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 8 35 1.6094379124341 NA 3.08680036127524 2.91370230854397 0.173098052731277 1.55949099355369 1.50761015097119 0.114136090351678 0.110996506838959 0.114816189463681 0.772327603437508 NA NA NA 0.781354735756608 99.727107917785 a8954 loss_cnaBRCA34 1059 AZD8055 MTORC1/2 5 38 0.693147180559945 NA 0.00616337198428263 0.146781702289409 -0.140618330305126 1.66515809977704 0.91781373533337 0.138507575708926 0.0844474349456394 0.153210095787083 0.772404832893897 NA NA NA 0.861461532290609 99.727107917785 a8955 gain_cnaBRCA8_(CHD4,WNK1) 302 PI-103 PI3Ka, PRKDC (DNAPK) 4 44 2.32630161961136 NA 1.38826007377853 1.1048125308253 0.283447542953225 2.20968011552169 1.83998789771915 0.151874142319454 0.128275373870713 0.154048590919857 0.772498614023285 NA NA NA 0.817825426610772 99.727107917785 a8956 loss_cnaBRCA17 178 BAY 61-3606 SYK 11 37 2.07944154167984 NA 2.97125392854281 3.1327660061007 -0.161512077557894 1.49090959070056 1.65061207250423 0.099869192116914 0.108331235217289 0.0978498099270865 0.772504431638094 NA NA NA 0.761930255294847 99.727107917785 a8957 loss_cnaBRCA7_(FAS,PTEN) 200 LAQ824 HDAC 4 44 0.0237165266173161 NA -2.48681204151966 -2.70243607973638 0.215624038216722 1.1248003334399 1.43851165930784 0.151830149527387 0.191699834900735 0.149893841194497 0.772562639894879 NA NA NA 0.738832787928529 99.727107917785 a8958 loss_cnaBRCA38 1024 CEP-701 FLT3, JAK2, NTRK1, RET 3 42 0.693147180559945 NA 0.860108048701764 0.608816127616701 0.251291921085062 1.42148329635797 1.44713246022166 0.173790239451311 0.176781480112293 0.173648182175784 0.772597227377029 NA NA NA 0.792165667078553 99.727107917785 a8959 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 301 PHA-793887 CDK-pan 7 41 2.32630161961136 NA 2.75460239211231 2.95089606707928 -0.196293674966975 1.35575387467927 1.69273311825796 0.118772912858924 0.144785627120861 0.11596256542141 0.772794543492527 NA NA NA 0.740924469114481 99.727107917785 a8960 gain_cnaBRCA8_(CHD4,WNK1) 223 ZSTK474 PI3K 4 45 1.63315443905142 2.32630161961136 0.709658502864434 0.930353913196362 -0.220695410331928 1.65087442335102 1.44296397675392 0.151459856990808 0.133683947858342 0.152945890463879 0.772869516462721 NA NA NA 0.81065153821439 99.727107917785 a8961 loss_cnaBRCA42 295 NVP-BHG712 EPHB4 3 46 2.32630161961136 NA 4.08748790537491 3.87361392710753 0.213873978267385 0.236973475401719 1.26318927758481 0.172899127819278 0.902522857905616 0.169312692929367 0.772971865484411 NA NA NA 0.370266899372592 99.727107917785 a8962 MLL3_mut 176 IPA-3 PAK1, PAK2, PAK3 3 44 3.46573590279973 NA 4.25060301042684 4.51362829815662 -0.263025287729781 1.20075148330248 1.53294493731446 0.173074437904422 0.21905056240811 0.171581693071488 0.773111348871379 NA NA NA 0.74743149071525 99.727107917785 a8963 gain_cnaBRCA10_(MDM2,NUP107) 1133 JNJ-26854165 MDM2 3 40 2.30258509299405 NA 3.11083269584308 2.95816451222297 0.152668183620103 0.537077842617793 0.892867510372322 0.173711614406883 0.284257088089833 0.170986380226156 0.773132156542541 NA NA NA 0.685351622976538 99.727107917785 a8964 PIK3CA_mut 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 16 30 2.30258509299405 NA 1.35451685028182 1.44445921662041 -0.0899423663385956 0.709855069371559 1.12381267007326 0.0897547852482417 0.126705253254333 0.0800332375081095 0.773228642921778 NA NA NA 0.741855852595393 99.727107917785 a8965 PIK3CA_mut 203 BMS-345541 IKBKB 17 32 2.77258872223978 NA 3.47470362940254 3.56294729458094 -0.0882436651784011 0.863894435456203 1.08447480120038 0.0869583443798627 0.102146352096598 0.0813699544523546 0.773287421213602 NA NA NA 0.757639278144181 99.727107917785 a8966 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1046 681640 WEE1, CHEK1 6 30 0.693147180559945 NA 2.75015599144861 2.61052266203142 0.139633329417189 1.03956583225568 1.08218857188076 0.129767566730987 0.13431889071826 0.129028649022339 0.773449324082158 NA NA NA 0.773759038909576 99.727107917785 a8967 gain_cnaBRCA15 326 GSK690693 AKT 22 26 2.32630161961136 NA 3.02783831873365 2.8648966543196 0.162941664414049 2.13318022038201 1.76676303669172 0.0838766980097672 0.0763843874311142 0.0922260999523503 0.773464094686682 NA NA NA 0.777091312326655 99.727107917785 a8968 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 7 41 2.32630161961136 NA 5.02932728380656 4.94639630195753 0.0829309818490325 1.10166840615235 0.618264435456502 0.118388623115659 0.0752776256320847 0.13413513230435 0.773508912243192 NA NA NA 0.851946483151207 99.727107917785 a8969 loss_cnaBRCA33 1072 BMS-708163 g-secretase 5 41 1.6094379124341 NA 3.56672096848487 3.69858254945165 -0.131861580966782 0.392298808049252 1.00086205898576 0.137129109647076 0.336125367350663 0.131748006413997 0.773569183641418 NA NA NA 0.584912248741445 99.727107917785 a8970 loss_cnaBRCA28_(GPS2) 290 KIN001-260 IKK 4 45 2.99573227355399 NA 4.8986960214242 5.05699608955268 -0.15830006812848 0.624183987261347 1.07156075577867 0.150945623885727 0.253611228995209 0.147728504683292 0.773618927575888 NA NA NA 0.671459092601044 99.727107917785 a8971 loss_cnaBRCA18 54 CGP-082996 CDK4 5 7 1.63315443905142 NA 2.91536944392775 2.73317225827695 0.182197185650808 0.678353175141284 1.24124556918658 0.173052477645528 0.268587503276388 0.146785769209397 0.773624461064958 NA NA NA 0.751362469313681 99.727107917785 a8972 BRCA1_mut 1026 17-AAG HSP90 4 39 0 NA -0.648288407566778 -0.921634162293448 0.27334575472667 1.28184789728536 1.83445453013312 0.151877108311145 0.213243517663483 0.149006557664219 0.773823899448541 NA NA NA 0.716356578701764 99.727107917785 a8973 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 272 AR-42 HDAC 9 40 1.63315443905142 NA 0.00801517849369683 0.172108144716708 -0.164092966223012 0.787363783946515 1.65259271842513 0.106551112164273 0.20840806952096 0.0992942570746571 0.773997329289695 NA NA NA 0.661320800776707 99.727107917785 a8974 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1230 IOX2 EGLN1 8 39 -2.30258509299405 NA 0.188309481594305 0.262006964763636 -0.0736974831693309 0.495706416447074 0.68402521847171 0.111954763607611 0.148671634508083 0.107740886124038 0.774326626680807 NA NA NA 0.72704580420174 99.727107917785 a8975 loss_cnaBRCA17 207 AS601245 JNK 11 37 2.07944154167984 NA 2.36484029185359 2.23687543299552 0.127964858858066 1.10185416876662 1.34007070984569 0.0990420063582626 0.116135930221425 0.0954911243995488 0.774335768183696 NA NA NA 0.751587094346202 99.727107917785 a8976 gain_cnaBRCA13_(FGFR1,WHSC1L1) 295 NVP-BHG712 EPHB4 11 38 2.32630161961136 NA 3.98133492913566 3.85931631954155 0.122018609594114 1.46776357861317 1.16682697115623 0.0986405403309395 0.0831323323265757 0.10457301091798 0.774535728483718 NA NA NA 0.803598285144808 99.727107917785 a8977 gain_cnaBRCA9_(KRAS) 1043 JNK Inhibitor VIII JNK 4 39 2.30258509299405 NA 4.9004194978213 4.78675802049494 0.113661477326359 0.53937519388202 0.765816079206728 0.151233223324363 0.210728039805296 0.148418765827032 0.774755889517788 NA NA NA 0.719239552867305 99.727107917785 a8978 CDH1_mut 135 Gemcitabine DNA replication 4 43 0.0237165266173161 NA -0.658156394624747 -0.239602086489111 -0.418554308135636 2.69847518883773 2.78813925532946 0.15043726290582 0.155107710408823 0.150119585072941 0.774831292050908 NA NA NA 0.783499995493147 99.727107917785 a8979 loss_cnaBRCA36_(FAT1,IRF2) 177 GSK-650394 SGK3 9 38 2.77258872223978 NA 3.86729777760427 4.04928800340892 -0.181990225804642 1.74339466915693 1.69965288118886 0.106582162805302 0.104388426226316 0.107074937370356 0.775043926011333 NA NA NA 0.782097409451188 99.727107917785 a8980 loss_cnaBRCA7_(FAS,PTEN) 235 QL-XII-47 BTK, BMX 4 45 2.32630161961136 NA 1.91651848184175 1.68954679375208 0.226971688089668 2.14645231085222 1.460956193235 0.149913960826984 0.105742711795703 0.15535831200187 0.775123065025365 NA NA NA 0.848115773623315 99.727107917785 a8981 MACF1_mut 1047 Nutlin-3a MDM2 3 40 2.07944154167984 1.38629436111989 4.36898949661645 4.19479119841673 0.174198298199716 0.997768873876241 1.01343989692686 0.172016937135277 0.174587825658433 0.171888139324249 0.775283473142829 NA NA NA 0.794815168994708 99.727107917785 a8982 gain_cnaBRCA58_(CCND1) 298 OSI-930 KIT, VEGFR, PDGFR 10 38 2.32630161961136 NA 3.8423016642385 3.9320687786011 -0.0897671143626044 0.850289773598906 0.886721752616837 0.102041423687298 0.105572379146299 0.101234817007353 0.775317798246685 NA NA NA 0.772617755866304 99.727107917785 a8983 loss_cnaBRCA42 164 JQ12 HDAC 3 44 1.63315443905142 NA 1.84297678664028 1.55980860662581 0.283168180014463 0.152946474820203 1.69032783283458 0.171341617246686 1.85142011509153 0.167522639403982 0.77531959983638 NA NA NA 0.299856477881872 99.727107917785 a8984 loss_cnaBRCA60 1067 CCT007093 PPM1D 3 43 1.88706964903238 NA 3.92658042316496 4.09673314023705 -0.170152717072083 0.583660313552044 1.00787721744736 0.171432303852939 0.291526960324861 0.168822862672723 0.775395875119646 NA NA NA 0.678050810720425 99.727107917785 a8985 gain_cnaBRCA14_(RAD21) 293 MP470 PDGFR 21 27 2.99573227355399 NA 3.61045103237841 3.47024506454371 0.140205967834695 1.79217922288339 1.58979080899276 0.0834170601021573 0.07823211319743 0.0881914570405178 0.77563041001117 NA NA NA 0.779108457118746 99.727107917785 a8986 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 6 39 0.693147180559945 NA 0.467953103317511 0.649817509900043 -0.181864406582532 1.58799423729566 1.42625118486271 0.125771694164119 0.114524601104501 0.127512186151164 0.775640190241559 NA NA NA 0.79976408409238 99.727107917785 a8987 PIK3CA_mut 158 PF-562271 FAK 15 30 0.940007258491471 NA 2.41173446343556 2.29400807661281 0.117726386822751 1.46762327852214 1.20778995311732 0.0906906454711319 0.0802156715184423 0.0974725667479668 0.775651285545377 NA NA NA 0.790616579313341 99.727107917785 a8988 gain_cnaBRCA62 175 PAC-1 CASP3 agonist 9 39 0.940007258491471 NA 2.29537318103433 2.4258453281236 -0.130472147089268 1.49859283717015 1.16664746633342 0.106003834898734 0.0870631060372901 0.111835109451976 0.775666211360309 NA NA NA 0.811515425908011 99.727107917785 a8989 loss_cnaBRCA36_(FAT1,IRF2) 295 NVP-BHG712 EPHB4 9 40 2.32630161961136 NA 3.99340379716062 3.86270175471564 0.13070204244498 1.22746143431521 1.23896626439716 0.105659174817045 0.106481587764016 0.105492817844056 0.775836789771253 NA NA NA 0.778185067121936 99.727107917785 a8990 loss_cnaBRCA29_(MAP2K4) 282 EKB-569 EGFR 7 40 0.916290731874155 2.99573227355399 1.79068727460754 1.54085898311503 0.249828291492507 1.90015708202706 2.16355651765467 0.117272708535805 0.131477704583241 0.115471118713055 0.776009634357596 NA NA NA 0.760670799635545 99.727107917785 a8991 PTEN_mut 207 AS601245 JNK 8 40 2.07944154167984 NA 2.38554157085014 2.24233254161057 0.143209029239568 1.20426291361513 1.30717570957903 0.110839130685959 0.118918408613667 0.109556066709416 0.776021067919629 NA NA NA 0.768070517481803 99.727107917785 a8992 gain_cnaBRCA9_(KRAS) 293 MP470 PDGFR 4 44 2.99573227355399 NA 3.76180889956551 3.51065574600829 0.251153153557218 2.29075153734099 1.62973621655665 0.1494257611265 0.109637884974966 0.154106628425956 0.776064339861895 NA NA NA 0.842876828977261 99.727107917785 a8993 loss_cnaBRCA22_(SYNCRIP,ZNF292) 83 JW-7-52-1 MTOR 3 9 0.182321556793955 NA -2.34906195392593 -1.9101997773494 -0.438862176576529 2.21390369083066 2.26205694658484 0.194832626617435 0.198230021655489 0.194010224737757 0.776069791508189 NA NA NA 0.784016667108773 99.727107917785 a8994 gain_cnaBRCA61_(NOTCH2) 179 5-Fluorouracil DNA antimetabolite 3 46 3.46573590279973 NA 3.78091754706748 4.05846967550959 -0.277552128442119 2.17857013629675 1.60004033861849 0.170397608583505 0.127401052560978 0.173465706921966 0.77616553260801 NA NA NA 0.847213175126933 99.727107917785 a8995 gain_cnaBRCA64_(SDHC) 268 YM155 BIRC5 (Survivin) 8 41 1.63315443905142 NA -3.44680323170546 -3.62460722544439 0.177803993738933 1.57735230586216 1.61417624731247 0.1105233992532 0.112723069588279 0.110151536447751 0.776171488676588 NA NA NA 0.777304460689278 99.727107917785 a8996 loss_cnaBRCA36_(FAT1,IRF2) 312 AV-951 VEGFR 9 39 -2.05572501506252 NA 0.576821288615047 0.645073054524959 -0.0682517659099124 0.44068975100132 0.681296366479809 0.105665594077625 0.154874865491728 0.10017926011049 0.77636232874493 NA NA NA 0.713474266758839 99.727107917785 a8997 loss_cnaBRCA33 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 6 43 1.63315443905142 NA 3.46669880814784 3.59199988750226 -0.125301079354426 0.874721225660933 1.02107780356976 0.124489404327843 0.143246871893099 0.122714526666199 0.776396382812994 NA NA NA 0.75705362424191 99.727107917785 a8998 loss_cnaBRCA42 256 JW-7-24-1 LCK 3 45 2.32630161961136 NA 1.65048581968931 1.85004134923637 -0.199555529547058 0.388794451786694 1.19506925960565 0.170326055109411 0.513267431235209 0.166982396997566 0.776432022330841 NA NA NA 0.516001275029519 99.727107917785 a8999 loss_cnaBRCA18 294 MPS-1-IN-1 MPS1 16 33 2.99573227355399 NA 4.68738407011792 4.79003704008692 -0.102652969968998 1.11842264658619 1.20786437430862 0.0869899208741599 0.0917837011637142 0.0849871659040826 0.776474657496597 NA NA NA 0.771092568923197 99.727107917785 a9000 gain_cnaBRCA15 59 WZ-1-84 BMX 6 6 2.32630161961136 NA 3.45741002636836 3.66638403515512 -0.208974008786758 1.49665289172136 0.920972399067794 0.168173426294045 0.139627571591706 0.226905832355324 0.776785834901145 NA NA NA 0.777970771065938 99.727107917785 a9001 gain_cnaBRCA16 329 QL-XI-92 DDR1 16 32 2.32630161961136 NA 4.19786183648104 4.28107172904846 -0.0832098925674174 1.10329587323791 0.871016258146886 0.0873135688178966 0.075419381677932 0.0955319625657149 0.776797842736091 NA NA NA 0.794421883084195 99.727107917785 a9002 gain_cnaBRCA10_(MDM2,NUP107) 283 GSK2126458 PI3K, MTOR 5 43 -2.05572501506252 0.0237165266173161 -2.85684676417752 -3.07844059468494 0.22159383050742 1.09237018459775 1.68821651288155 0.13470798801465 0.202855985664804 0.131259129866696 0.776849894834202 NA NA NA 0.701105462379468 99.727107917785 a9003 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1010 Gefitinib EGFR 8 37 -0.693147180559945 NA 1.49581244635031 1.37915951593889 0.116652930411423 0.808076334516315 1.08983723810164 0.111189256545858 0.144358800559661 0.107037020146805 0.776883698286648 NA NA NA 0.734861591107093 99.727107917785 a9004 loss_cnaBRCA36_(FAT1,IRF2) 179 5-Fluorouracil DNA antimetabolite 9 40 3.46573590279973 NA 4.18119365604455 4.01004037025607 0.17115328578848 1.31309092395143 1.68634197785253 0.105075422770766 0.130343819050577 0.101493818001515 0.777041377318417 NA NA NA 0.743159240241918 99.727107917785 a9005 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1072 BMS-708163 g-secretase 6 40 1.6094379124341 NA 3.5800362733949 3.69988179323931 -0.119845519844409 0.842803757162081 0.975804041151031 0.124629131520235 0.142198606527287 0.122817199755643 0.777230262205882 NA NA NA 0.759668749454794 99.727107917785 a9006 loss_cnaBRCA34 262 VX-11e ERK 5 44 1.63315443905142 NA 3.93827758056969 3.75846357688 0.179814003689685 0.535480698563288 1.39072290302944 0.134252806935292 0.335799225204815 0.129295349417193 0.777299753144019 NA NA NA 0.582659695572911 99.727107917785 a9007 BRCA1_mut 1058 GDC0941 PI3K (class 1) 4 39 1.38629436111989 0.693147180559945 1.53526459833132 1.32659107941356 0.208673518917767 0.994555090646756 1.42389212628061 0.149377018018195 0.209815947734044 0.146551494362743 0.777444529865525 NA NA NA 0.72066742141758 99.727107917785 a9008 POLR2B_mut 1013 Nilotinib ABL 3 37 0.693147180559945 NA 3.0503300654389 3.21527851621367 -0.164948450774769 0.816872602110982 0.973031847618597 0.170852628887466 0.201926775789156 0.169520094515369 0.777486770302249 NA NA NA 0.766392406876604 99.727107917785 a9009 loss_cnaBRCA34 135 Gemcitabine DNA replication 5 42 0.0237165266173161 NA -0.609532934459077 -0.235425014886556 -0.37410791957252 2.85320015670383 2.77530194207518 0.134459247342754 0.131118708476699 0.13479899750756 0.777547178664947 NA NA NA 0.792292353608819 99.727107917785 a9010 gain_cnaBRCA62 1019 Bosutinib SRC, ABL, TEC 8 37 0.693147180559945 NA 2.7483358570166 2.6440607384545 0.104275118562101 1.05744364364856 0.916386264543866 0.110837658404552 0.0986105682212196 0.113789482226695 0.777569985869546 NA NA NA 0.801438037247471 99.727107917785 a9011 gain_cnaBRCA14_(RAD21) 202 GSK-1904529A IGF1R 21 27 0.0237165266173161 NA 2.22864564302384 2.15936347747505 0.0692821655487874 1.11106979898024 0.542345898670312 0.0826322504189507 0.0623562674571625 0.127745347975616 0.777683772141118 NA NA NA 0.794927856261214 99.727107917785 a9012 loss_cnaBRCA57 186 Bexarotene Retinioic acid X family agonist 5 42 2.07944154167984 NA 3.46660258074447 3.62081056716766 -0.154207986423198 1.14644483719895 1.14808758506269 0.134334341225747 0.134509730795218 0.134317266756942 0.777748214612746 NA NA NA 0.787580677537391 99.727107917785 a9013 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 302 PI-103 PI3Ka, PRKDC (DNAPK) 14 34 2.32630161961136 NA 1.00926842897499 1.17750098958169 -0.168232560606699 2.11489082191728 1.75891622883192 0.0901368392181417 0.0795466881142287 0.0956455787086693 0.777800928775511 NA NA NA 0.795456225333161 99.727107917785 a9014 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1016 Temsirolimus MTOR 15 29 -1.6094379124341 NA -1.66108955895998 -1.79741582126458 0.136326262304601 1.92705321529959 1.24940080549216 0.0903137296197452 0.0707433822907722 0.109113313922429 0.777828845579894 NA NA NA 0.80638576741531 99.727107917785 a9015 gain_cnaBRCA63 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 6 40 0 NA 0.429245022486678 0.686810663861653 -0.257565641374974 4.25545305406584 1.59109967103199 0.124184002348255 0.0605260211081133 0.161879011141972 0.778004311860137 NA NA NA 0.88885519702369 99.727107917785 a9016 gain_cnaBRCA63 291 KIN001-266 MAP3K8 (COT) 7 42 2.99573227355399 NA 3.89637228072675 3.75901143033428 0.137360850392473 1.73848764466472 1.08380446183631 0.115657804520807 0.0790116920382047 0.126739513657048 0.778189035503593 NA NA NA 0.845386956040188 99.727107917785 a9017 BRCA1_mut 288 KIN001-055 JAK3, MNK1 4 45 2.32630161961136 NA 4.45582834613617 4.32862286904647 0.127205477089695 0.846174219085871 0.861856525865992 0.147764882434393 0.150330126137754 0.147594725191503 0.778259156624979 NA NA NA 0.789471345277709 99.727107917785 a9018 loss_cnaBRCA33 171 AKT inhibitor VIII AKT1, AKT2, AKT3 6 41 0.940007258491471 NA 2.02493464838273 1.86871588032625 0.15621876805648 1.0894485344082 1.28184950341997 0.123794404070819 0.143392517519278 0.121869819849903 0.778309199223151 NA NA NA 0.757851572340716 99.727107917785 a9019 gain_cnaBRCA14_(RAD21) 231 FMK RSK 21 28 2.99573227355399 2.32630161961136 5.61711405852372 5.56831642650034 0.0487976320233789 0.671693463224723 0.535584533589702 0.0816961683987557 0.0726486629616836 0.091110980551133 0.778416656344211 NA NA NA 0.785633673330474 99.727107917785 a9020 TP53_mut 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 33 9 1.38629436111989 0.693147180559945 3.40942050025667 3.52146385191329 -0.112043351656627 1.07364344361448 0.961992076160775 0.10647863459656 0.104358064423536 0.116470139862047 0.778522389698306 NA NA NA 0.767197162466352 99.727107917785 a9021 POLR2B_mut 263 FR-180204 ERK 3 46 2.99573227355399 NA 5.47461464944684 5.35027207892991 0.124342570516927 0.331603638687832 0.750930894144999 0.16849564852462 0.374973480414616 0.165584571744784 0.778596368022722 NA NA NA 0.607596698400068 99.727107917785 a9022 gain_cnaBRCA61_(NOTCH2) 192 LFM-A13 BTK 3 45 2.77258872223978 NA 4.66229798126555 4.80434826712844 -0.142050285862894 1.17686941602875 0.823966277161643 0.16862774880925 0.120701824627435 0.172398179149056 0.778600899389985 NA NA NA 0.854986026810985 99.727107917785 a9023 loss_cnaBRCA17 1004 Vinblastine Microtubules 8 37 -2.30258509299405 NA -3.33835660682913 -3.48090170674674 0.142545099917612 1.56832069826565 1.23173714683914 0.110284931555517 0.0908902752321301 0.115726882381852 0.778649221482943 NA NA NA 0.814620181672199 99.727107917785 a9024 ASH1L_mut 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 39 -1.38629436111989 0.693147180559945 -0.571209887803081 -0.281547728890827 -0.289662158912254 1.19562576995627 1.73171005247954 0.169501660279128 0.242268246629418 0.167269433181094 0.77870779025507 NA NA NA 0.725705580437318 99.727107917785 a9025 gain_cnaBRCA31 34 Imatinib ABL, KIT, PDGFR 4 10 0.693147180559945 NA 2.71840372228471 2.80100016875425 -0.0825964464695401 0.730672025978855 0.369972814205374 0.169975172301 0.113041752705516 0.223250042430659 0.778775717520952 NA NA NA 0.841059211678895 99.727107917785 a9026 gain_cnaBRCA12_(TERT) 184 BMS-754807 IGF1R 9 39 0.940007258491471 NA 1.77028211512687 1.59377360996134 0.176508505165534 1.81946849756806 1.66129435836086 0.104451137352671 0.097011025693195 0.106247579953073 0.77886327004715 NA NA NA 0.794643766711927 99.727107917785 a9027 loss_cnaBRCA18 1049 PD-173074 FGFR1, FGFR3 12 31 0.693147180559945 NA 3.01750553347681 2.90689629561111 0.110609237865695 0.989387360520686 1.2052961071883 0.0960691317360909 0.111795685167723 0.0917693479685448 0.778930598684839 NA NA NA 0.760225867326934 99.727107917785 a9028 BRCA1_mut 301 PHA-793887 CDK-pan 4 44 2.32630161961136 NA 3.14566363391782 2.90196138544012 0.243702248477696 1.82956147605215 1.63971750620505 0.147451376346022 0.133202546986046 0.148624532918306 0.778943315152605 NA NA NA 0.811620973965424 99.727107917785 a9029 loss_cnaBRCA60 1502 Bicalutamide ANDR (androgen receptor) 3 42 2.30258509299405 NA 4.65082155999082 4.55169467387453 0.0991268861162959 0.345104656435619 0.597011035412025 0.168671022645407 0.287237173616023 0.166038616100092 0.779113099587342 NA NA NA 0.682799833510533 99.727107917785 a9030 POLR2B_mut 1020 Lenalidomide TNFA 3 42 1.6094379124341 NA 4.14214197302547 4.26276833430262 -0.120626361277156 0.382326529990687 0.727755198787179 0.168614626383356 0.315506123208595 0.165751287628289 0.779184972751483 NA NA NA 0.658020910485246 99.727107917785 a9031 loss_cnaBRCA7_(FAS,PTEN) 135 Gemcitabine DNA replication 4 43 0.0237165266173161 NA -0.650507239574262 -0.240313635796133 -0.410193603778129 2.68367288448857 2.78926779419663 0.1474268833508 0.152847840043776 0.147061391750043 0.779215203066588 NA NA NA 0.786621146320556 99.727107917785 a9032 PTEN_mut 172 Embelin XIAP 8 40 3.46573590279973 NA 3.08172484195307 2.97532964736531 0.106395194587765 1.0233294493578 0.965240486223449 0.109201279764373 0.103969640133521 0.11022661824313 0.779241544617124 NA NA NA 0.792131469549309 99.727107917785 a9033 MLL3_mut 344 THZ-2-49 CDK9 3 46 2.99573227355399 NA 2.01923098819106 1.77001699584379 0.24921399234727 2.8168945502844 1.39499018555297 0.167987807468477 0.0884711826795605 0.178649280065352 0.77924580321988 NA NA NA 0.892730023243005 99.727107917785 a9034 POLR2B_mut 177 GSK-650394 SGK3 3 44 2.77258872223978 NA 4.28340025730061 3.9961005308199 0.287299726480708 2.49837981889063 1.6616545388045 0.168250542788727 0.114994415304027 0.172899793411578 0.779263421621323 NA NA NA 0.861622262133667 99.727107917785 a9035 gain_cnaBRCA47_(EGFR) 255 CP724714 ERBB2 7 41 2.32630161961136 NA 3.96842208385917 3.77479898301283 0.193623100846342 1.3425693168943 1.72469619655649 0.115266214677953 0.14421832706131 0.1122650477417 0.779320555754435 NA NA NA 0.743243373699746 99.727107917785 a9036 gain_cnaBRCA14_(RAD21) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 20 25 -0.669430653942629 NA -3.37121434534116 -3.57817320613063 0.20695886078947 2.48028238708019 2.42306347281839 0.0845243697897432 0.0834416523971306 0.085412067455561 0.779488374515072 NA NA NA 0.780142460458794 99.727107917785 a9037 loss_cnaBRCA28_(GPS2) 1371 PLX4720 (rescreen) BRAF 4 43 2.30258509299405 NA 4.83683102953014 4.69508374510362 0.14174728442652 0.299996112229104 0.993540202605356 0.147197819793058 0.472497071289608 0.142668896593029 0.779549079771918 NA NA NA 0.519375739264118 99.727107917785 a9038 gain_cnaBRCA48 266 Zibotentan, ZD4054 Endothelin A Receptor 5 44 2.99573227355399 NA 5.68295792138178 5.7487531871304 -0.0657952657486192 0.725078976298493 0.468683231712769 0.13273352198578 0.090742205882871 0.140383229645693 0.77975250707474 NA NA NA 0.851697788433529 99.727107917785 a9039 PTEN_mut 329 QL-XI-92 DDR1 9 39 2.32630161961136 NA 4.33384062618471 4.23475689942526 0.0990837267594546 0.725871560840588 0.994254855250862 0.103967687737206 0.136503111714022 0.099656266435284 0.779859502215337 NA NA NA 0.736787012557726 99.727107917785 a9040 loss_cnaBRCA60 309 Y-39983 ROCK 3 46 2.99573227355399 NA 5.10644941074055 4.92379820006809 0.182651210672456 0.500055813249483 1.10946614614336 0.167494059243007 0.365261648465888 0.164629818861417 0.77987736883014 NA NA NA 0.615464817955956 99.727107917785 a9041 PIK3CA_mut 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 16 32 2.32630161961136 NA 4.99863334902132 4.93841893070511 0.060214418316205 0.959101185420416 0.532080425311438 0.0859547967991179 0.0627821331383407 0.11316788863443 0.780178441394861 NA NA NA 0.817559409982493 99.727107917785 a9042 gain_cnaBRCA8_(CHD4,WNK1) 1502 Bicalutamide ANDR (androgen receptor) 3 42 2.30258509299405 NA 4.65033144110665 4.55172968236625 0.0986017587403971 1.01172401851863 0.558845138300226 0.167775841140387 0.0974591459089503 0.176438429866819 0.780254177352558 NA NA NA 0.88215504657525 99.727107917785 a9043 loss_cnaBRCA36_(FAT1,IRF2) 1161 ZG-10 IRAK1 3 23 2.30258509299405 NA 1.75787060745493 2.00378537806436 -0.245914770609429 1.38852226068634 1.42281182693959 0.173181124666695 0.177105385755843 0.172837170701893 0.780267834065456 NA NA NA 0.795102813174705 99.727107917785 a9044 loss_cnaBRCA36_(FAT1,IRF2) 1010 Gefitinib EGFR 8 37 -0.693147180559945 NA 1.30574873808202 1.42025437178068 -0.114505633698664 0.967215560578736 1.064378565927 0.109138768440858 0.118386881234778 0.107579800424614 0.780888587014343 NA NA NA 0.771190347048071 99.727107917785 a9045 gain_cnaBRCA48 1194 SB-505124 TGFR1 (ALK5) 5 42 2.30258509299405 NA 4.27969483964344 4.4020114999119 -0.122316660268455 0.401321324679746 0.960278449008358 0.132322522640912 0.304784851306028 0.127376242166807 0.780988339140784 NA NA NA 0.609799251534064 99.727107917785 a9046 CDH1_mut 295 NVP-BHG712 EPHB4 4 45 2.32630161961136 NA 3.72099762142471 3.90143808616383 -0.180440464739115 1.38461955596551 1.22635955838549 0.14586159261456 0.130317720822087 0.147135041681141 0.781039693455016 NA NA NA 0.815397217282716 99.727107917785 a9047 NF1_mut 196 Phenformin AAPK1 (AMPK) agonist 5 43 8.29404964010203 NA 7.41770317972886 7.17693284036691 0.240770339361953 1.97528591617789 1.80867980259543 0.132017814957033 0.121891386654462 0.133119382997726 0.781187983569879 NA NA NA 0.805492677260952 99.727107917785 a9048 loss_cnaBRCA7_(FAS,PTEN) 1164 XMD8-92 MAP2K5 (ERK5) 3 23 2.30258509299405 NA 4.08564582743337 3.85825113796138 0.227394689471992 0.715285331830362 1.36067436286896 0.172398141027988 0.317907664749822 0.167119110697826 0.781234363754062 NA NA NA 0.672169649832861 99.727107917785 a9049 loss_cnaBRCA20 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 3 43 1.63315443905142 NA 2.18667748889316 1.91914735649205 0.26753013240111 0.738800534527417 1.63317577102248 0.166853635714795 0.36211415652567 0.163809760803405 0.781234697117603 NA NA NA 0.620029778840183 99.727107917785 a9050 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 6 42 2.07944154167984 NA 3.08971122529392 3.2321023401766 -0.142391114882686 1.57695790079928 1.10889978652263 0.121817365300885 0.0902948105402906 0.128407559107939 0.781404869970245 NA NA NA 0.838142446078026 99.727107917785 a9051 gain_cnaBRCA63 260 NG-25 MAP3K7 (TAK1) 7 42 2.32630161961136 NA 3.33464956411172 3.18729237810259 0.147357186009122 1.69848543113585 1.22327028932829 0.113904321119727 0.0867579923311902 0.120461673347791 0.781463132589472 NA NA NA 0.831921274344873 99.727107917785 a9052 loss_cnaBRCA24 1377 Afatinib (rescreen) ERBB2, EGFR 3 44 2.30258509299405 NA 3.14636917365874 2.81338587702615 0.332983296632586 2.41197380394854 1.98065100419505 0.166342327691051 0.138054275750206 0.168118106585825 0.781701006727132 NA NA NA 0.83521759383765 99.727107917785 a9053 gain_cnaBRCA27_(CLTC,PPM1D) 230 GSK429286A ROCK2 9 40 2.99573227355399 2.32630161961136 5.48122738998044 5.38846573012337 0.092761659857068 0.739543263982922 0.93293223563312 0.102732376060913 0.12543101178082 0.0994302225971608 0.781881856764061 NA NA NA 0.751420203990156 99.727107917785 a9054 loss_cnaBRCA29_(MAP2K4) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 7 40 -2.30258509299405 NA -0.0392115112204983 -0.158349818001385 0.119138306780887 0.779417369572622 1.07931283902103 0.114082778548536 0.152855596284971 0.110383479630381 0.781941045394366 NA NA NA 0.733287269134118 99.727107917785 a9055 gain_cnaBRCA10_(MDM2,NUP107) 290 KIN001-260 IKK 5 44 2.99573227355399 NA 5.16774330281328 5.03002026367048 0.137723039142803 0.67423334215905 1.07703312152959 0.131315826402112 0.204266135373523 0.127872612633501 0.782043297350759 NA NA NA 0.700266508499017 99.727107917785 a9056 gain_cnaBRCA15 154 CHIR-99021 GSK3B 22 25 0.940007258491471 NA 3.23596907061107 3.31016851326401 -0.0741994426529371 0.957771513418157 0.87042740297844 0.081338586176439 0.0774709224626334 0.0852448376499183 0.782098026142569 NA NA NA 0.783478637814587 99.727107917785 a9057 PIK3CA_mut 1502 Bicalutamide ANDR (androgen receptor) 16 29 2.30258509299405 NA 4.52550052325419 4.57640112450468 -0.0509006012504924 0.784688699104735 0.447862255316716 0.0866084473246688 0.0648672541207307 0.113652357719891 0.782262632875808 NA NA NA 0.813561868202944 99.727107917785 a9058 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1161 ZG-10 IRAK1 5 21 2.30258509299405 NA 2.13491599161455 1.93743312189392 0.19748286972063 1.91281315479291 1.29923476204021 0.139069518054147 0.103242111873708 0.151999373393088 0.782276202011873 NA NA NA 0.83535367808024 99.727107917785 a9059 loss_cnaBRCA18 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 14 31 2.30258509299405 NA 1.43378587387114 1.33440575663516 0.0993801172359765 1.03982650995316 1.13939521047743 0.0895126718128969 0.0955737483942905 0.0872218141011266 0.782355319142825 NA NA NA 0.775545190110158 99.727107917785 a9060 gain_cnaBRCA62 63 BMS-509744 ITK 4 8 2.32630161961136 NA 3.46683165408978 3.66083220205546 -0.19400054796568 0.502747530641812 1.29322639137721 0.173760665714382 0.385880658067116 0.150012827807419 0.782390048943333 NA NA NA 0.717956916932221 99.727107917785 a9061 NF1_mut 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 38 1.38629436111989 0.693147180559945 3.29427108492179 3.44807807463165 -0.153806989709855 1.58661026111739 0.996498190822192 0.146162838870651 0.0969406246002306 0.154347485149924 0.782400740623221 NA NA NA 0.860569451027941 99.727107917785 a9062 loss_cnaBRCA18 86 A-443654 AKT1, AKT2, AKT3 5 7 0.0237165266173161 NA -1.15009745969066 -1.36443827795029 0.21434081825963 1.38346563224328 1.22522942175337 0.166045793326902 0.154930352633392 0.174939333364111 0.782518726564831 NA NA NA 0.788499417536497 99.727107917785 a9063 gain_cnaBRCA63 261 TL-1-85 MAP3K7 (TAK1) 7 42 2.32630161961136 NA 3.9063469855339 4.0445497126775 -0.138202727143603 1.8693540829938 1.09300220171802 0.113286661291747 0.0739307381094272 0.126443228500702 0.782617380759759 NA NA NA 0.854743063273906 99.727107917785 a9064 NF1_mut 202 GSK-1904529A IGF1R 5 43 0.0237165266173161 NA 2.09123724169416 2.20112060899666 -0.109883367302502 0.613835876824239 0.856801598424444 0.131051655757472 0.179010988850959 0.128248322020599 0.782747707832992 NA NA NA 0.730188522752816 99.727107917785 a9065 ASH1L_mut 1046 681640 WEE1, CHEK1 3 33 0.693147180559945 NA 2.46847657889411 2.64882382039248 -0.180347241498373 0.940460489357823 1.08405240900179 0.16758772647119 0.191764825358607 0.166363950673233 0.782762347585106 NA NA NA 0.77793532731893 99.727107917785 a9066 loss_cnaBRCA22_(SYNCRIP,ZNF292) 231 FMK RSK 19 30 2.99573227355399 2.32630161961136 5.61893637361564 5.57041546907701 0.0485209045386368 0.718818939104352 0.507495186561359 0.0812299985014632 0.0675008710804055 0.0956086004823029 0.782957730512905 NA NA NA 0.79934449938761 99.727107917785 a9067 loss_cnaBRCA24 290 KIN001-260 IKK 3 46 2.99573227355399 NA 5.20655919358471 5.03347675075681 0.173082442827905 0.610165899788037 1.06410695993259 0.165028962231417 0.283664562192072 0.162655117713795 0.783032771345405 NA NA NA 0.685301545225822 99.727107917785 a9068 gain_cnaBRCA8_(CHD4,WNK1) 179 5-Fluorouracil DNA antimetabolite 4 45 3.46573590279973 NA 4.25754220910147 4.02227086396084 0.235271345140623 1.18484893654984 1.65488370666588 0.144432275087446 0.198566532730922 0.142167902308149 0.783129702717012 NA NA NA 0.731951099013408 99.727107917785 a9069 loss_cnaBRCA34 225 Genentech Cpd 10 AURKA, AURKB 5 44 2.32630161961136 NA 2.82756624091578 3.03971085665708 -0.212144615741296 0.599139318804556 1.6884185311317 0.130598392309143 0.354082279501504 0.125646936366601 0.783203312198334 NA NA NA 0.575418222170273 99.727107917785 a9070 loss_cnaBRCA60 1069 EHT 1864 Rac GTPases 3 43 2.30258509299405 NA 3.42779750312265 3.57074431061664 -0.142946807493991 0.909217162743305 0.862650049456742 0.165290603639292 0.157219653732326 0.165706600937439 0.783230854566301 NA NA NA 0.813852133415135 99.727107917785 a9071 gain_cnaBRCA30_(CRNKL1,FOXA2) 265 Tubastatin A HDAC6 5 44 2.99573227355399 NA 4.81383755784865 4.67788698598367 0.135950571864987 1.99013291099668 0.90446621259306 0.130485948673197 0.0683123077427532 0.150310282431914 0.783385166809737 NA NA NA 0.886977018764374 99.727107917785 a9072 gain_cnaBRCA58_(CCND1) 170 Shikonin unknown 9 38 2.77258872223978 NA 0.10262089337757 -0.0198424133209394 0.122463306698509 0.459487281235612 1.30026789500271 0.102492771989374 0.266521646408126 0.0941831350056167 0.783448441317868 NA NA NA 0.641203219559018 99.727107917785 a9073 gain_cnaBRCA63 35 NVP-TAE684 ALK 3 11 0.693147180559945 NA 1.9525831159624 1.72406865921024 0.228514456752166 1.85236410831623 1.09047864805336 0.182792349339203 0.123363681970648 0.209554269732922 0.78376563340325 NA NA NA 0.854264630814142 99.727107917785 a9074 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 16 27 0.693147180559945 NA 1.58993111488316 1.73647496639913 -0.146543851515974 1.9260456471664 1.52665410237301 0.0870317048075674 0.0760853470589184 0.0959902123789462 0.784043041338777 NA NA NA 0.7970540249211 99.727107917785 a9075 TP53_mut 328 SNX-2112 HSP90 38 10 0.940007258491471 NA 0.375353307322211 0.576409224620682 -0.20105591729847 1.883927092659 2.63913198652187 0.0979015264317017 0.106721708118066 0.0761825927332429 0.784195467528758 NA NA NA 0.824992652953062 99.727107917785 a9076 gain_cnaBRCA31 197 Bryostatin 1 PRKC 16 32 -4.8283137373023 NA -2.75213222196707 -2.83413977365231 0.0820075516852468 1.19251385141652 0.846505754346651 0.0842875170351909 0.0687686365972479 0.0968777250055928 0.784332468114617 NA NA NA 0.808002334200493 99.727107917785 a9077 loss_cnaBRCA23 176 IPA-3 PAK1, PAK2, PAK3 3 44 3.46573590279973 NA 4.73028604611349 4.48092263663253 0.249363409480954 0.194166493534782 1.55424725581238 0.16406920724375 1.28427621543407 0.1604399869766 0.784607621359773 NA NA NA 0.344584038736582 99.727107917785 a9078 gain_cnaBRCA47_(EGFR) 253 XMD14-99 EPHB3, CAMK1 7 41 2.32630161961136 NA 5.00784595955386 4.9203406491177 0.0875053104361596 0.698174140515638 0.789648494749101 0.112427441255264 0.125334505187391 0.110815522372348 0.784615369219552 NA NA NA 0.770801075939657 99.727107917785 a9079 loss_cnaBRCA18 271 VNLG/124 HDAC, RAR 16 33 1.63315443905142 NA 4.10528374676301 4.1738189462938 -0.0685351995307908 0.725077332282751 0.858911000489519 0.0837246105187079 0.094521227570337 0.0797931328062285 0.784647543023267 NA NA NA 0.772271769932255 99.727107917785 a9080 gain_cnaBRCA63 287 KIN001-244 PDPK1 (PDK1) 7 42 2.99573227355399 NA 3.56933205304168 3.46290170665977 0.106430346381909 1.2185404740395 0.902838772740898 0.112149161391394 0.0873424795067242 0.11788411131126 0.784744368323028 NA NA NA 0.831138408103257 99.727107917785 a9081 PTEN_mut 257 NPK76-II-72-1 PLK3 9 40 2.32630161961136 NA 3.34708560350877 3.50863210311939 -0.161546499610623 1.51592421343206 1.61099615436393 0.101269491647138 0.106566342947238 0.100277396176905 0.784908458090793 NA NA NA 0.77998331565439 99.727107917785 a9082 gain_cnaBRCA27_(CLTC,PPM1D) 271 VNLG/124 HDAC, RAR 9 40 1.63315443905142 NA 4.08377772349809 4.16666414161052 -0.0828864181124214 0.949118439871802 0.789139237523506 0.101256257169787 0.0873298996525838 0.105033958737798 0.784935854667741 NA NA NA 0.812087363322973 99.727107917785 a9083 gain_cnaBRCA58_(CCND1) 1243 piperlongumine Increases ROS levels 9 38 2.30258509299405 NA 1.63962130650905 1.72697435150808 -0.0873530449990263 0.545006948665869 0.913320115561337 0.101637542780926 0.160278772982362 0.0956434042245288 0.785209452643622 NA NA NA 0.713298692840024 99.727107917785 a9084 gain_cnaBRCA15 269 NSC-207895 MDM4 22 27 2.99573227355399 NA 4.55209875181525 4.64618537167848 -0.0940866198632309 1.39972482228855 1.00122877081413 0.0786804973271029 0.0672179405301961 0.093971150855689 0.78532781186913 NA NA NA 0.79258412061197 99.727107917785 a9085 gain_cnaBRCA58_(CCND1) 294 MPS-1-IN-1 MPS1 10 39 2.99573227355399 NA 4.84768868764356 4.73314052739281 0.114548160250753 1.08519635686389 1.20152594670152 0.097063355287513 0.105555238484016 0.0953355693776032 0.785411013163183 NA NA NA 0.774868632253253 99.727107917785 a9086 ARID1A_mut 1043 JNK Inhibitor VIII JNK 4 39 2.30258509299405 NA 4.89539585250546 4.78727326616836 0.108122586337101 0.464169566376691 0.769772615959526 0.143849565410602 0.232937689519601 0.14046042181213 0.785467089507722 NA NA NA 0.698120575450645 99.727107917785 a9087 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1166 QL-VIII-58 MTOR, ATR 5 21 2.30258509299405 NA -1.64475817043411 -1.48909109804629 -0.155667072387812 0.498937536831278 1.22477324093784 0.136975071154638 0.311997115663906 0.127098688299733 0.785469359879764 NA NA NA 0.660510394447055 99.727107917785 a9088 loss_cnaBRCA17 1061 SB590885 BRAF 6 36 1.6094379124341 NA 4.1254640865366 3.99298629806117 0.132477788475422 0.582577736909431 1.15120058976983 0.120832983090468 0.227399332453408 0.115077936593056 0.785476761216108 NA NA NA 0.671820227388576 99.727107917785 a9089 gain_cnaBRCA64_(SDHC) 269 NSC-207895 MDM4 8 41 2.99573227355399 NA 4.70975289129918 4.58329644987466 0.126456441424521 0.9378991814003 1.23541936676482 0.105749742842229 0.134829461345429 0.102359121790094 0.785589803819782 NA NA NA 0.747235406459896 99.727107917785 a9090 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 222 BX-912 PDPK1 (PDK1) 9 40 2.32630161961136 NA 4.00916922826644 3.85556837898057 0.153600849285867 1.1338498421335 1.5896812110681 0.100935909995314 0.135468422341397 0.096623680406126 0.785599086400951 NA NA NA 0.739458936506741 99.727107917785 a9091 loss_cnaBRCA23 226 GSK1070916 AURKB 3 46 0.940007258491471 2.32630161961136 2.70373090125641 2.38439663146704 0.319334269789365 0.690295354797018 1.99856710026828 0.162862525817323 0.462605271164349 0.159781610408026 0.785808925532323 NA NA NA 0.549378673453525 99.727107917785 a9092 loss_cnaBRCA42 205 BMS-708163 g-secretase 3 45 2.32630161961136 0.940007258491471 4.79212862213169 4.90348957731882 -0.111360955187134 0.249697248051256 0.696950628268965 0.162899689091138 0.445983910740878 0.159783133367315 0.785929152452563 NA NA NA 0.560883485689189 99.727107917785 a9093 loss_cnaBRCA33 1175 AG-014699 PARP1, PARP2 4 39 1.6094379124341 NA 3.72694888791711 3.87537800861819 -0.148429120701085 0.918720982437163 1.04282166900481 0.143514303353511 0.161560608213535 0.142334135464153 0.78595446047483 NA NA NA 0.777111516253346 99.727107917785 a9094 PTEN_mut 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 8 37 -0.669430653942629 NA -3.70068960390444 -3.43981351969874 -0.2608760842057 1.9214110134212 2.53847833515658 0.106538943956508 0.135773180430143 0.102768686497223 0.78597505658983 NA NA NA 0.74874706798686 99.727107917785 a9095 gain_cnaBRCA64_(SDHC) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 8 39 0.940007258491471 NA 1.77763440443393 1.91143291662054 -0.133798512186608 1.15851961735483 1.28014942253179 0.106021059404888 0.115490933586521 0.104517886608886 0.785978348719337 NA NA NA 0.775721309691791 99.727107917785 a9096 gain_cnaBRCA12_(TERT) 152 CP466722 ATM 9 40 2.77258872223978 NA 2.64227223779578 2.74991240332557 -0.107640165529791 0.735008744021472 1.12460395044115 0.100751719198232 0.146447462571474 0.095713842626612 0.785980499150117 NA NA NA 0.72638103581056 99.727107917785 a9097 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 38 -1.38629436111989 0.693147180559945 -0.0800519953754411 -0.325625871280256 0.245573875904814 0.888318193710375 1.75885669239836 0.14369299021541 0.276448098939737 0.139621310233042 0.785984097819407 NA NA NA 0.658459150856832 99.727107917785 a9098 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1230 IOX2 EGLN1 6 41 -2.30258509299405 NA 0.318029296217215 0.239428578078853 0.0786007181383617 0.610699748620516 0.664056858308087 0.119391946036521 0.128705993928947 0.11836443996471 0.78599124836441 NA NA NA 0.779596956069749 99.727107917785 a9099 gain_cnaBRCA61_(NOTCH2) 152 CP466722 ATM 3 46 2.77258872223978 NA 2.56697690988221 2.74078294659865 -0.173806036716439 0.268410806543206 1.09038718279823 0.162683224865814 0.647537403410997 0.159398459059658 0.786038815174826 NA NA NA 0.458224809790752 99.727107917785 a9100 gain_cnaBRCA14_(RAD21) 1038 NU-7441 PRKDC (DNAPK) 19 24 0.693147180559945 NA 2.93744534022288 2.85757225873751 0.0798730814853736 1.1479407630399 0.764327486287546 0.0839026896535918 0.0695794452614948 0.104501124084035 0.786050132013746 NA NA NA 0.795926089037737 99.727107917785 a9101 gain_cnaBRCA58_(CCND1) 299 OSI-027 MTORC1/2 10 38 2.99573227355399 NA 1.42243406283192 1.22858416910374 0.193849893728182 1.76395290199789 2.05130701133412 0.09700548288138 0.109895164155814 0.0945006733058973 0.786120829512033 NA NA NA 0.769190565123409 99.727107917785 a9102 gain_cnaBRCA27_(CLTC,PPM1D) 300 CX-5461 RNA Pol I 9 40 2.32630161961136 NA 4.05364198580433 3.88057803739309 0.173063948411249 1.3154513345582 1.79094609024899 0.100658208117313 0.131562410455399 0.096632695620217 0.786174157346667 NA NA NA 0.74466078686097 99.727107917785 a9103 gain_cnaBRCA31 223 ZSTK474 PI3K 16 33 1.63315443905142 2.32630161961136 0.830772161376057 0.951885015856883 -0.121112854480825 1.61469675001958 1.3773017085458 0.0831091971779473 0.0750065636035724 0.0879348756553128 0.786190667737104 NA NA NA 0.798475394514649 99.727107917785 a9104 PTEN_mut 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 6 37 0.693147180559945 NA 2.80884165580543 2.92456632125289 -0.115724665447464 1.00039122194452 0.957750796081051 0.120164511758672 0.115679409124085 0.120829620733273 0.786196835502553 NA NA NA 0.799573779473499 99.727107917785 a9105 PTEN_mut 1371 PLX4720 (rescreen) BRAF 8 39 2.30258509299405 NA 4.62253435276324 4.72450385475565 -0.101969501992413 0.574670387244315 1.01853746985633 0.105884766488235 0.177439979953345 0.100113648255666 0.786246574840117 NA NA NA 0.700220831907262 99.727107917785 a9106 loss_cnaBRCA57 1373 Dabrafenib BRAF 5 41 2.30258509299405 NA 4.40426284366811 4.19145819103096 0.212804652637152 0.741096555494714 1.71107304143603 0.129232920073494 0.287148349374118 0.124369122465137 0.786270378088738 NA NA NA 0.627540017173616 99.727107917785 a9107 gain_cnaBRCA13_(FGFR1,WHSC1L1) 294 MPS-1-IN-1 MPS1 11 38 2.99573227355399 NA 4.67106720874642 4.78125337233012 -0.1101861635837 1.34242563899859 1.13230109713271 0.0933665637962202 0.0820799010259484 0.097311716700373 0.786280181151463 NA NA NA 0.807720246581317 99.727107917785 a9108 loss_cnaBRCA34 1133 JNJ-26854165 MDM2 3 40 2.30258509299405 NA 2.8352628377007 2.97883225158365 -0.143569413882953 0.797283982007367 0.882949413631387 0.163339293637251 0.180073119644872 0.162602083048542 0.786327053428473 NA NA NA 0.789401244430056 99.727107917785 a9109 gain_cnaBRCA62 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 5 9 1.38629436111989 NA 1.83860964688336 1.96612478667319 -0.12751513978983 0.978301944411954 0.736107144381594 0.154605185131046 0.1303433367563 0.173229047922033 0.786356815455959 NA NA NA 0.807087809443717 99.727107917785 a9110 ASH1L_mut 1036 PLX4720 BRAF 3 40 2.30258509299405 NA 4.41261538512034 4.61041570131598 -0.197800316195644 0.344985281489208 1.23963986932135 0.163279001994559 0.573358710672506 0.159562725506667 0.786403942528581 NA NA NA 0.500747829995398 99.727107917785 a9111 loss_cnaBRCA29_(MAP2K4) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 7 39 2.30258509299405 NA 1.50826618086886 1.39610725223178 0.112158928637082 1.63185678437294 0.861701540267976 0.111912658458981 0.0687308651783317 0.130159833069583 0.786409257244777 NA NA NA 0.864460759424374 99.727107917785 a9112 gain_cnaBRCA16 231 FMK RSK 16 33 2.99573227355399 2.32630161961136 5.62260379180643 5.57304831824559 0.0495554735608366 0.740693110817272 0.516633692376883 0.0829597080980829 0.066904191273168 0.0959199415215181 0.786565636886298 NA NA NA 0.811963299994922 99.727107917785 a9113 loss_cnaBRCA33 1058 GDC0941 PI3K (class 1) 5 38 1.38629436111989 0.693147180559945 1.50606765342839 1.32494137429768 0.181126279130704 1.77008804786131 1.35058948633273 0.1296470351249 0.102326140979003 0.134109054574768 0.786586819116482 NA NA NA 0.83485158429994 99.727107917785 a9114 gain_cnaBRCA58_(CCND1) 207 AS601245 JNK 9 39 2.07944154167984 NA 2.37189267213131 2.241810261078 0.130082411053308 0.893600359903605 1.36127053603171 0.10067104240455 0.145571126523875 0.0955595582289729 0.78666269039008 NA NA NA 0.728659773907892 99.727107917785 a9115 gain_cnaBRCA14_(RAD21) 177 GSK-650394 SGK3 21 26 2.77258872223978 NA 4.08986198648725 3.95352009275942 0.136341893727826 1.97912675460154 1.45448185187276 0.0798406979734486 0.0688899250191159 0.0937391508544949 0.786769060535657 NA NA NA 0.793734841261507 99.727107917785 a9116 loss_cnaBRCA20 1243 piperlongumine Increases ROS levels 3 44 2.30258509299405 NA 1.5796321208322 1.71915274439527 -0.139520623563072 0.359469357726174 0.875803452694325 0.162333793758554 0.388129392851759 0.159305861530746 0.786828770538511 NA NA NA 0.601499624883496 99.727107917785 a9117 PIK3CA_mut 1061 SB590885 BRAF 14 28 1.6094379124341 NA 4.07698175629133 3.97937666647655 0.097605089814782 1.02613791310667 1.12865139874527 0.0890243537108749 0.0951188807742999 0.0864793947212491 0.787041035380554 NA NA NA 0.780791040392556 99.727107917785 a9118 loss_cnaBRCA23 178 BAY 61-3606 SYK 3 45 2.07944154167984 NA 3.34132090732084 3.07938161594965 0.261939291371188 1.21701483696437 1.63329566843041 0.161948249796703 0.215230976168334 0.160374692980671 0.787148305836968 NA NA NA 0.752125944610721 99.727107917785 a9119 loss_cnaBRCA20 274 PXD101, Belinostat HDAC 3 45 2.99573227355399 NA 0.442892978364109 0.686744037139318 -0.243851058775209 0.746504540274185 1.53146290973285 0.161934018755238 0.326657167665241 0.159227531548738 0.787166545279624 NA NA NA 0.64883655733913 99.727107917785 a9120 gain_cnaBRCA64_(SDHC) 326 GSK690693 AKT 8 40 2.32630161961136 NA 2.76940290549081 2.97361331951309 -0.204210414022282 1.91012312461035 1.9486634989562 0.105108797126339 0.106909555405722 0.10479511425737 0.787305532142114 NA NA NA 0.788759604718333 99.727107917785 a9121 loss_cnaBRCA57 1001 AICAR AAPK1 (AMPK) agonist 5 40 7.60090245954208 NA 7.89767179027446 7.71858473387788 0.179087056396583 1.32500790865059 1.39734100314797 0.128768179452591 0.135159235825971 0.128162743376978 0.787330835547224 NA NA NA 0.788009276320165 99.727107917785 a9122 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 6 43 1.63315443905142 NA 3.68104685304512 3.56209085798171 0.118955995063405 0.696973045939798 1.03732926670174 0.118175296076824 0.170675172815335 0.114675251997501 0.787449242405333 NA NA NA 0.723772405585155 99.727107917785 a9123 MACF1_mut 1013 Nilotinib ABL 3 37 0.693147180559945 NA 3.34846857042091 3.19110512391783 0.157363446503075 0.658917392351149 0.979760128453462 0.162980518504639 0.238821206314756 0.160614258462906 0.787477333416543 NA NA NA 0.730524047126545 99.727107917785 a9124 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 63 BMS-509744 ITK 3 9 2.32630161961136 NA 3.44180064063242 3.64762025676729 -0.205819616134864 1.57776999334559 0.967706037921546 0.184309336661841 0.130449696091908 0.212688159492036 0.787821542899966 NA NA NA 0.847351782802747 99.727107917785 a9125 gain_cnaBRCA27_(CLTC,PPM1D) 63 BMS-509744 ITK 3 9 2.32630161961136 NA 3.44180064063242 3.64762025676729 -0.205819616134864 1.57776999334559 0.967706037921546 0.184309336661841 0.130449696091908 0.212688159492036 0.787821542899966 NA NA NA 0.847351782802747 99.727107917785 a9126 gain_cnaBRCA15 172 Embelin XIAP 22 26 3.46573590279973 NA 3.03444465443381 2.95804623971897 0.0763984147148413 1.0968325260518 0.858098815338675 0.0784080519581248 0.0696536735556593 0.0890321876096383 0.78785665755594 NA NA NA 0.792253320035635 99.727107917785 a9127 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 254 AC220 FLT3 5 43 0.0237165266173161 NA 2.3255529827863 2.21192572445907 0.113627258327236 0.841102758730189 0.893703349782293 0.127778337514296 0.135093194199932 0.127142030244058 0.788038679278747 NA NA NA 0.787550422876973 99.727107917785 a9128 gain_cnaBRCA15 298 OSI-930 KIT, VEGFR, PDGFR 22 26 2.32630161961136 NA 3.95063680767325 3.88183155616982 0.0688052515034316 0.864595228193734 0.892378431003231 0.0782052359943029 0.0795808827758347 0.0771032211368884 0.788391911619561 NA NA NA 0.78785899658928 99.727107917785 a9129 loss_cnaBRCA36_(FAT1,IRF2) 273 CUDC-101 HDAC, EGFR 9 40 1.63315443905142 NA -0.155014096605517 0.00223374540022607 -0.157247842005743 1.1872899437789 1.64796736273377 0.0995823095181034 0.132442663083 0.0954192695569458 0.788403285427834 NA NA NA 0.744349205730803 99.727107917785 a9130 TP53_mut 261 TL-1-85 MAP3K7 (TAK1) 38 11 2.32630161961136 NA 4.05011170200932 3.93738837771258 0.112723324296734 1.23134932022041 1.1770190013795 0.0923967487535567 0.0915445539666656 0.0957701822694617 0.788445396716292 NA NA NA 0.785294988740482 99.727107917785 a9131 POLR2B_mut 279 BIX02189 MAP2K5 (MEK5) 3 46 2.99573227355399 NA 5.16410868563778 5.01843739403921 0.145671291598577 0.25617984345528 0.924322837503589 0.160787723916526 0.568629013250238 0.157597849677723 0.788470294457389 NA NA NA 0.493656513879879 99.727107917785 a9132 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 14 33 2.77258872223978 NA 5.07326334200833 4.98444493663538 0.0888184053729546 0.75053682866802 1.12628166845959 0.0860740230079101 0.118339836208412 0.07885985172291 0.788498990292792 NA NA NA 0.753323527636147 99.727107917785 a9133 loss_cnaBRCA23 194 AUY922 HSP90 3 44 -1.36257783450257 NA -2.13155447584688 -2.41162384292422 0.280069367077335 0.640654216840927 1.77417788917168 0.161000603921292 0.437161513520289 0.15785867290235 0.788536334736291 NA NA NA 0.568675122704519 99.727107917785 a9134 PTEN_mut 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 36 -1.38629436111989 0.693147180559945 -0.4766433662374 -0.273170302575752 -0.203473063661648 1.22752293505933 1.76716835751097 0.119055765845419 0.165759072885928 0.115140735061733 0.788553677135463 NA NA NA 0.734446519543211 99.727107917785 a9135 PIK3CA_mut 272 AR-42 HDAC 17 32 1.63315443905142 NA 0.223381288430259 0.0987181403686625 0.124663148061597 2.10612811784581 1.14333778655752 0.0809388162365901 0.0591906764860559 0.109034398694148 0.788582458146646 NA NA NA 0.822658030648244 99.727107917785 a9136 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1028 VX-702 p38 5 40 0.693147180559945 NA 3.34849956551207 3.43662291509144 -0.0881233495793734 0.555501082998649 0.700981932249419 0.12794746219057 0.158637583753527 0.125714152569653 0.788652925256224 NA NA NA 0.757479543557984 99.727107917785 a9137 gain_cnaBRCA63 302 PI-103 PI3Ka, PRKDC (DNAPK) 7 41 2.32630161961136 NA 1.30420265066651 1.09842373406736 0.205778916599143 1.78593168920524 1.87837052523348 0.110244242022529 0.115222165462956 0.109551823686951 0.788694451757137 NA NA NA 0.786527190867108 99.727107917785 a9138 loss_cnaBRCA36_(FAT1,IRF2) 1502 Bicalutamide ANDR (androgen receptor) 9 36 2.30258509299405 NA 4.5110561759955 4.57011487218731 -0.0590586961918058 0.362893517080738 0.627930163088662 0.100484200103339 0.162743872271122 0.0940529690456467 0.788736641327583 NA NA NA 0.715541768069933 99.727107917785 a9139 ARID1A_mut 185 OSI-906 IGF1R 5 43 0.940007258491471 NA 3.02297836754984 2.8784331155091 0.144545252040746 0.58272695281265 1.17472540589707 0.127289203931978 0.248049710663062 0.123045991271777 0.788830186839035 NA NA NA 0.65908121737561 99.727107917785 a9140 NF1_mut 266 Zibotentan, ZD4054 Endothelin A Receptor 5 44 2.99573227355399 NA 5.7984754288946 5.73562619764031 0.0628492312542956 0.172288520931087 0.515604795590083 0.126780934901491 0.364790590311204 0.121894194530072 0.789384044301793 NA NA NA 0.574397339794923 99.727107917785 a9141 gain_cnaBRCA9_(KRAS) 330 XMD13-2 RIPK 4 44 2.32630161961136 NA 3.56354736313764 3.73533705170671 -0.17178968856907 1.22699904889325 1.22467548626827 0.140256270071966 0.140008004671254 0.140273640237981 0.789461207062766 NA NA NA 0.803377024994428 99.727107917785 a9142 gain_cnaBRCA9_(KRAS) 1377 Afatinib (rescreen) ERBB2, EGFR 4 43 2.30258509299405 NA 2.57761597725904 2.85854935351374 -0.280933376254696 1.51385472367522 2.03230231363641 0.140331924447847 0.18557485857868 0.138234048335073 0.789575865360092 NA NA NA 0.748205913871551 99.727107917785 a9143 ARID1A_mut 1378 Bleomycin (50 uM) DNA damage 5 43 3.91202300542815 NA 3.59698408001548 3.83780290772357 -0.240818827708093 2.9736657545309 1.76260358172888 0.126825000491566 0.0809838252134302 0.136626766338397 0.789581561169659 NA NA NA 0.86711168362142 99.727107917785 a9144 loss_cnaBRCA60 266 Zibotentan, ZD4054 Endothelin A Receptor 3 46 2.99573227355399 NA 5.81640633652286 5.737189365893 0.0792169706298642 0.44714220607441 0.497781736954878 0.15979789547273 0.177162812084622 0.159139969888138 0.789740857836121 NA NA NA 0.792087906045002 99.727107917785 a9145 loss_cnaBRCA28_(GPS2) 1017 Olaparib PARP1, PARP2 3 42 1.6094379124341 NA 4.20816126254723 4.06452215747997 0.143639105067257 0.885266051721992 0.896414650843178 0.160329540473901 0.162255295781257 0.16023734655848 0.789764664524517 NA NA NA 0.80859910795481 99.727107917785 a9146 gain_cnaBRCA12_(TERT) 292 Masitinib KIT 9 39 2.99573227355399 NA 4.09865374734906 3.98994437386148 0.108709373487584 1.28490524095975 1.05309019875748 0.0991032350328898 0.0846049732090623 0.103228929122926 0.78990407545025 NA NA NA 0.817794504034895 99.727107917785 a9147 gain_cnaBRCA8_(CHD4,WNK1) 219 AT-7519 CDK9 4 45 2.32630161961136 NA 1.9061790224128 1.65118463500661 0.254994387406192 2.01337112467526 1.81052570713326 0.139788262029713 0.126650464130065 0.14083997062375 0.78993146089436 NA NA NA 0.820582252922844 99.727107917785 a9148 loss_cnaBRCA42 282 EKB-569 EGFR 3 44 0.916290731874155 2.99573227355399 1.89684248808216 1.5563327905138 0.340509697568355 0.666191955673221 2.17480415974082 0.159821688124764 0.511128503832281 0.156570280612731 0.790047178804718 NA NA NA 0.526315014879771 99.727107917785 a9149 MACF1_mut 1033 Vismodegib SMO 3 42 2.30258509299405 NA 4.87750741152164 4.75136508097904 0.126142330542597 0.702104522072456 0.792035343165372 0.160062828114022 0.179663179166335 0.15926351220448 0.790105923926298 NA NA NA 0.789803712133631 99.727107917785 a9150 MLL3_mut 309 Y-39983 ROCK 3 46 2.99573227355399 NA 4.77200916485082 4.94560952045221 -0.173600355601383 1.8974321157243 1.04029777895531 0.159181350555771 0.0914922616533847 0.166875638027138 0.790532559078579 NA NA NA 0.889216523733101 99.727107917785 a9151 loss_cnaBRCA24 228 KIN001-102 AKT1 3 46 2.32630161961136 NA 2.15532212183814 1.92990238777198 0.225419734066159 0.591900918193783 1.44185757343681 0.159181250153101 0.380840318264819 0.15633980652392 0.790532688023177 NA NA NA 0.60660515276926 99.727107917785 a9152 gain_cnaBRCA30_(CRNKL1,FOXA2) 269 NSC-207895 MDM4 5 44 2.99573227355399 NA 4.46860703432821 4.61932141826394 -0.150714383935729 0.941145016317985 1.21683985723395 0.126030808796393 0.160139384815918 0.123857205235145 0.790600174975134 NA NA NA 0.7545476022291 99.727107917785 a9153 gain_cnaBRCA15 346 THZ-2-102-1 CDK7 22 26 0.916290731874155 2.99573227355399 -1.44248014291857 -1.24434628893746 -0.19813385398111 2.83499240648309 2.30764963631358 0.0773387985956485 0.0698886718454748 0.0858595910155687 0.790679696337945 NA NA NA 0.794343153172031 99.727107917785 a9154 loss_cnaBRCA7_(FAS,PTEN) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 4 39 -1.38629436111989 0.693147180559945 -2.09843151294078 -2.2330321386274 0.134600625686621 0.556286710347491 0.984547076810736 0.140250903238284 0.241962684318922 0.136713244959942 0.790702986625161 NA NA NA 0.690607351624903 99.727107917785 a9155 loss_cnaBRCA7_(FAS,PTEN) 274 PXD101, Belinostat HDAC 4 44 2.99573227355399 NA 0.863918379972966 0.65401107014704 0.209907309825926 1.25449404806597 1.52189917911931 0.139389217575769 0.167324277185321 0.137924583116863 0.790731397506439 NA NA NA 0.769588882461576 99.727107917785 a9156 ASH1L_mut 211 TL-2-105 CRAF 3 46 2.32630161961136 1.63315443905142 4.07106357269575 3.89689005155167 0.17417352114408 0.609574076672754 1.1122434826137 0.158981015878698 0.285729869115782 0.156596576079531 0.790789855588476 NA NA NA 0.684562572157031 99.727107917785 a9157 loss_cnaBRCA57 1007 Docetaxel Microtubules 5 40 -4.38202663467388 NA -4.41245108950169 -4.60913322628033 0.196682136778642 1.09682961989644 1.59418982831296 0.126512120080824 0.179318768577029 0.123374351840382 0.790966624565517 NA NA NA 0.732924006341701 99.727107917785 a9158 loss_cnaBRCA28_(GPS2) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 4 43 0.940007258491471 NA 2.04949800067713 1.87369690653405 0.175801094143077 1.32569775103612 1.25738033800712 0.139298054165521 0.132610237895989 0.139815367577413 0.791088875608636 NA NA NA 0.813070525632358 99.727107917785 a9159 loss_cnaBRCA29_(MAP2K4) 1091 BMS-536924 IGF1R 7 40 1.38629436111989 NA 3.12570368712124 3.00538196230729 0.120321724813948 0.939974993161824 1.12495995696875 0.109175879329215 0.128005240234337 0.106956451266195 0.79109054668349 NA NA NA 0.768682939581341 99.727107917785 a9160 gain_cnaBRCA13_(FGFR1,WHSC1L1) 5 Sunitinib PDGFRA, PDGFRB, KDR, KIT, FLT3 3 9 2.07944154167984 NA 3.05979017945425 3.32060826184394 -0.26081808238969 1.42481788779571 1.4416547322807 0.181337352875071 0.183053627150339 0.180915774456672 0.791150755718967 NA NA NA 0.799659547211985 99.727107917785 a9161 loss_cnaBRCA38 1054 PD-0332991 CDK4, CDK6 3 39 1.38629436111989 0.693147180559945 3.10194817782399 2.86605524296893 0.235892934855062 1.17819455710273 1.49108697666878 0.159708972177996 0.200215603978973 0.158201995286732 0.791176105102706 NA NA NA 0.76874306735252 99.727107917785 a9162 PIK3CA_mut 1017 Olaparib PARP1, PARP2 16 29 1.6094379124341 NA 4.02620539111281 4.10052166013778 -0.0743162690249699 1.02526884488224 0.818240708538493 0.0829506089392155 0.0724846652621201 0.090824458193617 0.791233552335747 NA NA NA 0.805026968677845 99.727107917785 a9163 gain_cnaBRCA10_(MDM2,NUP107) 1009 ATRA Retinoic acid and retinoid X receptor agonist 3 42 2.30258509299405 NA 4.2791716786059 4.0935993853701 0.185572293235807 1.65672466354327 1.1364352558764 0.159180884628387 0.112011547434152 0.163293326457649 0.791234670105385 NA NA NA 0.865269538183085 99.727107917785 a9164 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1025 SB 216763 GSK3A, GSK3B 14 25 2.30258509299405 NA 4.93437827920984 4.86383984350374 0.0705384357061041 0.584812066016326 0.886089030380988 0.0889086883964625 0.120617271436624 0.0796064879347112 0.791451597578891 NA NA NA 0.767031289974313 99.727107917785 a9165 gain_cnaBRCA62 55 A-770041 SRC family 4 8 1.63315443905142 NA 2.56869848737739 2.77305906123067 -0.204360573853278 1.01811572944855 1.3104590667806 0.166136926865874 0.200724306620789 0.155945789558563 0.791678076221794 NA NA NA 0.774350315870979 99.727107917785 a9166 POLR2B_mut 254 AC220 FLT3 3 45 0.0237165266173161 NA 2.09169423762924 2.23256640783964 -0.140872170210396 0.315246651187394 0.906776385541641 0.15841192405789 0.446863335993556 0.155354917106988 0.791684378054073 NA NA NA 0.562959043945761 99.727107917785 a9167 gain_cnaBRCA8_(CHD4,WNK1) 1375 Temozolomide DNA akylating agent 3 43 3.40119738166216 NA 6.00439895507932 5.8928510735796 0.111547881499718 0.537958375586193 0.709926656228648 0.158668873282675 0.207354112440703 0.157125923531727 0.791703735402514 NA NA NA 0.760809330081361 99.727107917785 a9168 gain_cnaBRCA8_(CHD4,WNK1) 1192 GSK269962A ROCK1, ROCK2 3 43 1.6094379124341 NA 2.88655652478904 2.65269157625026 0.233864948538785 2.29789597209204 1.42300894125938 0.158650950782324 0.101773514283969 0.164345382350031 0.791726703348604 NA NA NA 0.877174363852272 99.727107917785 a9169 gain_cnaBRCA9_(KRAS) 192 LFM-A13 BTK 4 44 2.77258872223978 NA 4.90254362258041 4.78573616986943 0.116807452710981 1.0035718553389 0.830071390463592 0.138647729306319 0.116391718330459 0.140719767062138 0.79181809810234 NA NA NA 0.834274176043988 99.727107917785 a9170 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 9 37 0 NA 0.817827314482229 0.613174347541787 0.204652966940442 2.19507387407253 2.04649336990206 0.0986612303793168 0.0932328380186805 0.100001773741508 0.791899330815936 NA NA NA 0.803840779175592 99.727107917785 a9171 gain_cnaBRCA10_(MDM2,NUP107) 265 Tubastatin A HDAC6 5 44 2.99573227355399 NA 4.80892506394163 4.67844522392765 0.130479840013979 1.16665211121684 1.02957763056238 0.125227085358848 0.111841258211831 0.12673142475202 0.791903783711676 NA NA NA 0.820587243147445 99.727107917785 a9172 loss_cnaBRCA34 192 LFM-A13 BTK 5 43 2.77258872223978 NA 4.88999467636172 4.78447889727367 0.105515779088045 0.646407052880926 0.858820563558925 0.125244470843742 0.163234263329553 0.122861262952055 0.79214136812724 NA NA NA 0.751242717964353 99.727107917785 a9173 gain_cnaBRCA47_(EGFR) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 6 37 0.693147180559945 NA 3.00515662112649 2.89273146201164 0.11242515911485 1.27932892315217 0.910535619500616 0.116732452740277 0.0878782282494191 0.123471456478012 0.792156061546375 NA NA NA 0.843082225039559 99.727107917785 a9174 ARID1A_mut 1005 Cisplatin DNA crosslinker 5 40 1.79175946922805 2.30258509299405 3.53698410312514 3.68672098264378 -0.149736879518635 1.19038014854281 1.19135721358409 0.125695549581305 0.125789126861645 0.125685963715421 0.792283748085969 NA NA NA 0.801355645812943 99.727107917785 a9175 loss_cnaBRCA60 1192 GSK269962A ROCK1, ROCK2 3 43 1.6094379124341 NA 2.44999306126014 2.68314949231041 -0.233156431050269 1.18147602153697 1.48659002039263 0.158169534136827 0.197343345781117 0.156839766076654 0.792343715727625 NA NA NA 0.77118127584629 99.727107917785 a9176 gain_cnaBRCA12_(TERT) 1026 17-AAG HSP90 9 34 0 NA -0.754836778682101 -0.933628086810961 0.17879130812886 1.57119805837668 1.85130726722275 0.0993242126601628 0.113792979297328 0.0965757069581836 0.792367254020671 NA NA NA 0.774482160100711 99.727107917785 a9177 gain_cnaBRCA10_(MDM2,NUP107) 260 NG-25 MAP3K7 (TAK1) 5 44 2.32630161961136 NA 3.06319604122163 3.22483742324961 -0.161641382027976 1.24348279422819 1.29838085832946 0.124935430713143 0.129990847302639 0.124494581840916 0.792376985182031 NA NA NA 0.794818326128135 99.727107917785 a9178 loss_cnaBRCA22_(SYNCRIP,ZNF292) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 18 30 2.77258872223978 NA -0.366615685259399 -0.478474111305878 0.111858426046479 1.52769641744089 1.34866900348562 0.0789142608516262 0.0732203235992771 0.0829398657175199 0.7924334179626 NA NA NA 0.799240453919063 99.727107917785 a9179 loss_cnaBRCA38 1262 UNC1215 LMBL3 3 43 0 NA 2.66918976669298 2.76368290587964 -0.0944931391866661 0.0969141304356744 0.611942121248598 0.157954653758707 0.975019213007177 0.154415157750317 0.792619162731842 NA NA NA 0.39502230384584 99.727107917785 a9180 gain_cnaBRCA19 1371 PLX4720 (rescreen) BRAF 4 43 2.30258509299405 NA 4.8289189980139 4.69581974803537 0.133099249978532 0.897099239599712 0.967611933710364 0.138202843582806 0.14836624991224 0.137554370033609 0.792692541720955 NA NA NA 0.793168264668176 99.727107917785 a9181 gain_cnaBRCA30_(CRNKL1,FOXA2) 299 OSI-027 MTORC1/2 5 43 2.99573227355399 NA 1.04538055606368 1.29496828544053 -0.249587729376856 1.86143271230805 2.01100154995764 0.124891280277856 0.134083669920781 0.124111157140636 0.792713708979993 NA NA NA 0.789406663271122 99.727107917785 a9182 loss_cnaBRCA20 1194 SB-505124 TGFR1 (ALK5) 3 44 2.30258509299405 NA 4.52545768609316 4.3796950940054 0.145762592087758 0.813645519268456 0.929302023936792 0.157671686669662 0.179147538621994 0.156851689045361 0.792804619003493 NA NA NA 0.790279510251281 99.727107917785 a9183 loss_cnaBRCA38 269 NSC-207895 MDM4 4 45 2.99573227355399 NA 4.45272083181704 4.61738431662191 -0.164663484804874 0.623947782259793 1.22518581848807 0.137692925293762 0.263905873995578 0.13439878451097 0.793005804733 NA NA NA 0.666596533101293 99.727107917785 a9184 gain_cnaBRCA48 196 Phenformin AAPK1 (AMPK) agonist 5 43 8.29404964010203 NA 7.40576725657788 7.17832073840772 0.22744651817016 1.54786092656898 1.84808148528126 0.124700786960048 0.146942476721292 0.12307169352738 0.793022448911278 NA NA NA 0.772223206142469 99.727107917785 a9185 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1061 SB590885 BRAF 4 38 1.6094379124341 NA 4.14955999066929 3.99742240228275 0.152137588386539 0.5204312093836 1.13035666688354 0.138755316680542 0.292329871159593 0.134592551929641 0.793161927280277 NA NA NA 0.648157197172828 99.727107917785 a9186 loss_cnaBRCA38 1061 SB590885 BRAF 3 39 1.6094379124341 NA 4.17284315198162 3.9995323536789 0.173310798302718 0.366179118550962 1.12178890581563 0.158065944410307 0.473295143066979 0.154495018986399 0.793273595287648 NA NA NA 0.556027422095357 99.727107917785 a9187 gain_cnaBRCA8_(CHD4,WNK1) 290 KIN001-260 IKK 4 45 2.99573227355399 NA 4.91166230434979 5.0558435310704 -0.144181226720613 0.685232488136365 1.06918131849433 0.137461869991056 0.210412129046514 0.134851988364008 0.793345020689264 NA NA NA 0.720413555477449 99.727107917785 a9188 ASH1L_mut 282 EKB-569 EGFR 3 44 0.916290731874155 2.99573227355399 1.26442773659713 1.59945197811506 -0.335024241517923 2.65363747218684 2.10312442960198 0.15724302792422 0.126250946118059 0.159298345263065 0.793354708071585 NA NA NA 0.848862057057853 99.727107917785 a9189 gain_cnaBRCA58_(CCND1) 1230 IOX2 EGLN1 9 38 -2.30258509299405 NA 0.197514296581653 0.2617662844553 -0.064251987873647 0.972275333362798 0.568149508353273 0.097590944721305 0.0660841488711015 0.113089929550191 0.793557114253845 NA NA NA 0.852851072215702 99.727107917785 a9190 gain_cnaBRCA14_(RAD21) 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 13 13 2.30258509299405 NA 4.63361978914208 4.73796375286531 -0.104343963723232 1.22472281384491 0.723749276038598 0.103729654919036 0.0851980240293335 0.144171423969296 0.793683534969717 NA NA NA 0.794204887225591 99.727107917785 a9191 loss_cnaBRCA36_(FAT1,IRF2) 288 KIN001-055 JAK3, MNK1 9 40 2.32630161961136 NA 4.27080791539365 4.35435178132732 -0.0835438659336774 0.885014649128793 0.855948136194021 0.0970351555919433 0.0943982859672637 0.0976038879004465 0.793687774132988 NA NA NA 0.801372455297578 99.727107917785 a9192 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 89 Parthenolide NFKB1 3 11 1.6094379124341 NA 3.44747398808644 3.19597245382238 0.251501534264065 1.78257521326247 1.36671772657112 0.174125887456019 0.14108887658309 0.184018637773172 0.793750212295642 NA NA NA 0.836718531875788 99.727107917785 a9193 loss_cnaBRCA7_(FAS,PTEN) 333 T0901317 LXR 4 44 2.32630161961136 NA 4.83224508130989 4.72663539918605 0.105609682123834 0.592640659932793 0.780554932708458 0.137209003015742 0.178201883981114 0.135300768335904 0.793927838076962 NA NA NA 0.75703451667339 99.727107917785 a9194 gain_cnaBRCA8_(CHD4,WNK1) 1050 ZM-447439 AURKB 3 36 1.38629436111989 0.693147180559945 3.08173435012032 2.87177322584564 0.209961124274676 1.99038047974178 1.28007302113258 0.158077623154786 0.105487933795409 0.164022771207932 0.793965966196871 NA NA NA 0.873019377700457 99.727107917785 a9195 loss_cnaBRCA24 1194 SB-505124 TGFR1 (ALK5) 3 44 2.30258509299405 NA 4.25332654807704 4.39824948977922 -0.14492294170218 1.3748545913665 0.898049178679954 0.15676203812964 0.105409650309375 0.161375284497452 0.793972079051024 NA NA NA 0.872931957216124 99.727107917785 a9196 loss_cnaBRCA23 135 Gemcitabine DNA replication 3 44 0.0237165266173161 NA 0.132009951417426 -0.302989662540523 0.434999613957949 1.30017410862218 2.8328239419088 0.15632344657486 0.334570278759763 0.15355688277078 0.794535146410842 NA NA NA 0.644611021112498 99.727107917785 a9197 loss_cnaBRCA36_(FAT1,IRF2) 201 Epothilone B Microtubules 9 39 -3.44201937618241 NA -4.37863659380691 -4.2027859242268 -0.175850669580113 2.59501757055654 1.60570987741833 0.0967871504975633 0.0677647317595616 0.109515842216058 0.794699359027613 NA NA NA 0.849617466760186 99.727107917785 a9198 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1017 Olaparib PARP1, PARP2 8 37 1.6094379124341 NA 3.99889371671912 4.09035850454183 -0.0914647878227104 1.15973982654327 0.835016412027586 0.102088668397575 0.0788666438190117 0.109536515097489 0.794703745291854 NA NA NA 0.837382107200536 99.727107917785 a9199 loss_cnaBRCA34 1047 Nutlin-3a MDM2 5 38 2.07944154167984 1.38629436111989 4.09542787522778 4.22161781711526 -0.126189941887479 0.642551800048299 1.04505622735624 0.124588537524376 0.196388745433433 0.120749428197478 0.794716729107656 NA NA NA 0.716207342695688 99.727107917785 a9200 gain_cnaBRCA19 1259 BMN-673 PARP1 4 42 2.30258509299405 NA 3.50152010054673 3.28687308239658 0.214647018150148 1.00406435663262 1.60158459946256 0.136884017813682 0.213778147518372 0.134021654692595 0.794854850157706 NA NA NA 0.718322163353911 99.727107917785 a9201 loss_cnaBRCA28_(GPS2) 326 GSK690693 AKT 4 44 2.32630161961136 NA 2.69633645512054 2.96169114099927 -0.26535468587873 1.9703392891838 1.94103425313682 0.136572463047359 0.134674615349447 0.136707884185919 0.794861754836638 NA NA NA 0.810514509273491 99.727107917785 a9202 PIK3CA_mut 87 GW843682X PLK1 4 8 -1.36257783450257 NA -1.69738942219501 -2.0233586501298 0.325969227934781 2.32220069872878 1.83466304810662 0.163517388122961 0.140370825016642 0.177672531351837 0.794877463155276 NA NA NA 0.816208279658242 99.727107917785 a9203 gain_cnaBRCA58_(CCND1) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 10 38 0.246860077931526 2.32630161961136 -0.142485929107506 -0.297179750904395 0.154693821796889 1.16798343122654 1.76448325098491 0.0929269991362483 0.1324452193936 0.0876708927163469 0.794901327962557 NA NA NA 0.743855529244231 99.727107917785 a9204 gain_cnaBRCA27_(CLTC,PPM1D) 279 BIX02189 MAP2K5 (MEK5) 9 40 2.99573227355399 NA 5.0986904582431 5.01130580146322 0.0873846567798742 0.51455600463697 0.966934702383389 0.0964480597458571 0.169825356214676 0.0903728623706238 0.794907198447849 NA NA NA 0.707227239729045 99.727107917785 a9205 gain_cnaBRCA8_(CHD4,WNK1) 1259 BMN-673 PARP1 3 43 2.30258509299405 NA 3.0766691432672 3.32150563797772 -0.244836494710513 0.842485227559133 1.59443255215569 0.156136238841295 0.290612210993727 0.153557135031828 0.794951188379435 NA NA NA 0.68203774483275 99.727107917785 a9206 ASH1L_mut 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 3 43 0 NA 0.350593015330117 0.674328317288275 -0.323735301958158 2.02525186288502 2.07665972218839 0.15606585292445 0.159849403370991 0.155892320007539 0.795041493039745 NA NA NA 0.811348014559633 99.727107917785 a9207 gain_cnaBRCA63 277 ABT-869 VEGFR and PDGFR family 7 41 0.0237165266173161 NA 2.73473871915274 2.68362402112968 0.0511146980230626 0.795150326863777 0.410700542039987 0.106780617152324 0.0642830623294448 0.124457342493806 0.795178128904952 NA NA NA 0.872908178591956 99.727107917785 a9208 gain_cnaBRCA16 157 JNK-9L JNK 16 31 1.63315443905142 NA -0.000496712763873003 0.0849235290982146 -0.0854202418620876 1.02390325020949 1.08221670494381 0.0803475523733294 0.0834260872251459 0.0789308106887172 0.795272213905538 NA NA NA 0.792124547067949 99.727107917785 a9209 PIK3CA_mut 202 GSK-1904529A IGF1R 17 31 0.0237165266173161 NA 2.23228267635106 2.16630860959223 0.065974066758828 0.877647679728982 0.816941516302521 0.0786758677788695 0.0751714706056088 0.080757392594548 0.795494233696232 NA NA NA 0.800259562081061 99.727107917785 a9210 POLR2B_mut 1264 SGC0946 Q8TEK3 (DOT1L) 3 43 -0.693147180559945 NA 1.86176747798116 1.95691921113553 -0.0951517331543614 0.500415958654074 0.616079117770928 0.155655576453475 0.190145281158265 0.154447262388369 0.795567931506936 NA NA NA 0.778894673554789 99.727107917785 a9211 gain_cnaBRCA10_(MDM2,NUP107) 1036 PLX4720 BRAF 3 40 2.30258509299405 NA 4.77251742975204 4.5834230479686 0.189094381783441 1.0772108591069 1.21800842370619 0.156080289048497 0.175540731125025 0.155248829238848 0.795599678227034 NA NA NA 0.794697053570009 99.727107917785 a9212 gain_cnaBRCA47_(EGFR) 1262 UNC1215 LMBL3 6 40 0 NA 2.81684281325064 2.74862193433499 0.0682208789156475 0.452447093915357 0.61443894011873 0.114035221578212 0.150782002654238 0.111029549823885 0.795712717936507 NA NA NA 0.752074590131642 99.727107917785 a9213 MLL3_mut 1025 SB 216763 GSK3A, GSK3B 3 36 2.30258509299405 NA 5.0038838408164 4.87960112428006 0.124282716536341 0.832633423180212 0.791112778757603 0.156643217247561 0.149264626036327 0.157098608281262 0.795792294773316 NA NA NA 0.823552108085739 99.727107917785 a9214 loss_cnaBRCA23 260 NG-25 MAP3K7 (TAK1) 3 46 2.32630161961136 NA 3.02004929632709 3.22062345521977 -0.200574158892681 0.86086452161439 1.30975759746106 0.155023300902744 0.232991549607064 0.153138381698636 0.795877670999519 NA NA NA 0.734890770473264 99.727107917785 a9215 loss_cnaBRCA34 253 XMD14-99 EPHB3, CAMK1 5 43 2.32630161961136 NA 4.84743255735997 4.94306338474193 -0.0956308273819522 0.726053986295331 0.783196676916351 0.12285653725642 0.131713108373533 0.122103208811452 0.796013222003851 NA NA NA 0.792988904709851 99.727107917785 a9216 loss_cnaBRCA42 225 Genentech Cpd 10 AURKA, AURKB 3 46 2.32630161961136 NA 3.25428157508955 3.00265791678743 0.251623658302122 1.36244520702807 1.63523471127191 0.154887263753017 0.184685341475856 0.153876172373081 0.79605271343209 NA NA NA 0.784338411173811 99.727107917785 a9217 gain_cnaBRCA63 293 MP470 PDGFR 7 41 2.99573227355399 NA 3.68420372427987 3.50552835006507 0.178675374214797 1.72308454983527 1.67465394092485 0.106287952752834 0.103695070698578 0.106693908423922 0.796101564022566 NA NA NA 0.805415521125203 99.727107917785 a9218 loss_cnaBRCA60 208 SB-715992 KIF11 3 46 -2.05572501506252 NA -1.48954392252119 -1.22361811146133 -0.26592581105986 0.396122977973521 1.75530939921416 0.154653068196383 0.671321346770335 0.15149797020338 0.796354083574859 NA NA NA 0.459672854943697 99.727107917785 a9219 loss_cnaBRCA28_(GPS2) 277 ABT-869 VEGFR and PDGFR family 4 44 0.0237165266173161 NA 2.75055644199288 2.68567113937305 0.0648853026198295 0.561578683456066 0.472367973683043 0.135546764249582 0.115540893077551 0.137361773521435 0.796367274987058 NA NA NA 0.835572683854019 99.727107917785 a9220 loss_cnaBRCA29_(MAP2K4) 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 3 23 2.30258509299405 NA 4.8280630524285 4.66723464733959 0.160828405088915 0.646171643027104 1.03247624356226 0.159874555065623 0.248894247874274 0.155769593820409 0.796741564331475 NA NA NA 0.730249439619735 99.727107917785 a9221 MACF1_mut 1149 TW 37 BCL2, BCL2L1 3 40 1.6094379124341 NA 0.0389696632486298 -0.15598578522466 0.19495544847329 1.33738901371887 1.25233443323415 0.155143092281897 0.145773179286988 0.155673631020284 0.796799066196868 NA NA NA 0.827141754034776 99.727107917785 a9222 loss_cnaBRCA57 229 LY317615 PRKCB (PKCbeta) 5 44 2.99573227355399 2.32630161961136 3.53685827584024 3.33832452611535 0.19853374972489 2.06958904713004 1.57695966238363 0.12219632888719 0.0959290686236492 0.125896530178077 0.796824930217105 NA NA NA 0.844403614077844 99.727107917785 a9223 loss_cnaBRCA18 1022 AZD7762 CHEK1, CHEK2 14 31 0.693147180559945 NA 0.810892154021483 0.947138409565419 -0.136246255543937 1.15750645280003 1.80256395964808 0.0833505852632567 0.117706692013988 0.0755846996799694 0.79698652038306 NA NA NA 0.76260662243488 99.727107917785 a9224 gain_cnaBRCA12_(TERT) 286 KIN001-236 TIE2 9 40 2.32630161961136 NA 4.47995945275473 4.55363651204374 -0.0736770592890172 0.742717905771496 0.778078080934384 0.0954151383856386 0.0991992501008648 0.0946910870442969 0.797053876537752 NA NA NA 0.794269734552448 99.727107917785 a9225 loss_cnaBRCA29_(MAP2K4) 1133 JNJ-26854165 MDM2 7 36 2.30258509299405 NA 3.04749822328482 2.9535164170404 0.0939818062444164 0.935526132262267 0.868993095027571 0.106913624968064 0.100458771811271 0.108150233623473 0.797068563403636 NA NA NA 0.811802452635048 99.727107917785 a9226 loss_cnaBRCA36_(FAT1,IRF2) 263 FR-180204 ERK 9 40 2.99573227355399 NA 5.30043476274775 5.37081116785967 -0.0703764051119151 0.600257321459255 0.763258546033427 0.0953531910568457 0.117243726308621 0.0922051976720782 0.797182669692638 NA NA NA 0.767551445095882 99.727107917785 a9227 loss_cnaBRCA20 1046 681640 WEE1, CHEK1 3 33 0.693147180559945 NA 2.78786915040752 2.61978813207308 0.168081018334436 0.537195978145764 1.10126282714854 0.156166029046659 0.312885846455143 0.152625707679285 0.797218307084688 NA NA NA 0.670043035105607 99.727107917785 a9228 PIK3CA_mut 51 Dasatinib ABL, SRC, KIT, PDGFR 4 8 0.246860077931526 NA 2.09136831871069 1.90235664985077 0.18901166885992 1.47034387735145 1.01566280964377 0.161443917906582 0.128549295012803 0.186096869025079 0.797412741241549 NA NA NA 0.827450207932301 99.727107917785 a9229 loss_cnaBRCA34 178 BAY 61-3606 SYK 5 43 2.07944154167984 NA 3.2724582793557 3.07520567541671 0.197252603938994 1.26992457015675 1.64683620840045 0.121945176367792 0.155326236356421 0.119776698455387 0.797492299427798 NA NA NA 0.76207045811046 99.727107917785 a9230 NF1_mut 229 LY317615 PRKCB (PKCbeta) 5 44 2.99573227355399 2.32630161961136 3.53618212614599 3.33840136130788 0.197780764838113 1.8819229875266 1.59869187087099 0.121732213897986 0.105095036379812 0.123714124304866 0.797579272365713 NA NA NA 0.830796153562885 99.727107917785 a9231 loss_cnaBRCA23 1192 GSK269962A ROCK1, ROCK2 3 43 1.6094379124341 NA 2.45596041996223 2.68273316495911 -0.226772744996873 1.18506370490308 1.48651997106209 0.153832321547948 0.191359117707026 0.152552773868789 0.797908567844358 NA NA NA 0.77776928980402 99.727107917785 a9232 loss_cnaBRCA60 151 QS11 ARFGAP 3 45 2.32630161961136 NA 3.97482824131517 3.74615800285162 0.228670238463548 1.90131552969096 1.46958889297942 0.153371000712139 0.120269484413624 0.155601501587254 0.798162986334061 NA NA NA 0.85576394444208 99.727107917785 a9233 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 225 Genentech Cpd 10 AURKA, AURKB 7 42 2.32630161961136 NA 3.16421147381258 2.99370544240005 0.170506031412527 1.75707478766583 1.60427925188004 0.104953563475177 0.0970397120312874 0.106282014937682 0.798237106989159 NA NA NA 0.816118182608927 99.727107917785 a9234 BRCA2_mut 1043 JNK Inhibitor VIII JNK 5 38 2.30258509299405 NA 4.87863127722579 4.78663380011734 0.0919974771084515 0.538230879200826 0.771266082619611 0.122382983773433 0.170925676440287 0.119281113459549 0.798268758182355 NA NA NA 0.745363844714598 99.727107917785 a9235 loss_cnaBRCA34 276 CAY10603 HDAC6 5 44 2.99573227355399 NA 1.06680835943064 1.18789558470679 -0.121087225276146 0.29608108829516 1.03994699827134 0.121274810002205 0.408966428667797 0.116435958253088 0.798322897701641 NA NA NA 0.561924329524541 99.727107917785 a9236 gain_cnaBRCA62 1032 Afatinib ERBB2, EGFR 8 37 -0.693147180559945 NA 0.442468172849137 0.257607595810492 0.184860577038646 2.09636978770826 1.79235460984501 0.100181216568966 0.0881812827691693 0.103138394614128 0.798453220562341 NA NA NA 0.821713915413914 99.727107917785 a9237 gain_cnaBRCA14_(RAD21) 1058 GDC0941 PI3K (class 1) 19 24 1.38629436111989 0.693147180559945 1.28447022221372 1.39471567784972 -0.110245455636008 1.49929310800754 1.31179404032482 0.0789038542111911 0.0735316230343487 0.0840417414983143 0.798503493516215 NA NA NA 0.801770809471489 99.727107917785 a9238 loss_cnaBRCA23 1377 Afatinib (rescreen) ERBB2, EGFR 3 44 2.30258509299405 NA 3.1217892870334 2.81506177838697 0.306727508646429 2.3897781701241 1.9821787351195 0.153206169818125 0.12834978262041 0.154742608833374 0.798540303168317 NA NA NA 0.846568364346741 99.727107917785 a9239 TP53_mut 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 34 9 1.6094379124341 NA 2.89694550115248 2.75845422539946 0.138491275753014 1.34683681641275 1.76587894441955 0.09629348646917 0.102827064173877 0.0784262569020759 0.798559286351986 NA NA NA 0.830797553325547 99.727107917785 a9240 gain_cnaBRCA64_(SDHC) 1032 Afatinib ERBB2, EGFR 9 36 -0.693147180559945 NA 0.431701786111889 0.255164176465953 0.176537609645936 1.96136559128288 1.81768596457052 0.095670634729576 0.0900074980567325 0.0971221724142258 0.798626020176699 NA NA NA 0.810708797284679 99.727107917785 a9241 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 8 35 1.6094379124341 NA 2.98562900396965 2.84106294388635 0.144566060083302 1.30743846517782 1.46370049778332 0.100517068837373 0.11057198019919 0.0987675144623079 0.798848772341876 NA NA NA 0.787690126675199 99.727107917785 a9242 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 6 41 2.99573227355399 NA 3.98815311268873 3.82710273749145 0.161050375197282 1.76819649573269 1.39077322009532 0.11202641864717 0.0910817183417998 0.115799163278571 0.798891617641253 NA NA NA 0.837969951912405 99.727107917785 a9243 gain_cnaBRCA58_(CCND1) 1164 XMD8-92 MAP2K5 (ERK5) 5 21 2.30258509299405 NA 4.02104091173165 3.85197662365493 0.169064288076716 1.30743646142461 1.32172359837793 0.128141800168203 0.129309754672514 0.127911984233465 0.798978067363196 NA NA NA 0.803908845497786 99.727107917785 a9244 loss_cnaBRCA22_(SYNCRIP,ZNF292) 207 AS601245 JNK 18 30 2.07944154167984 NA 2.32787044485081 2.2291988741303 0.098671570720509 1.49761169637629 1.15505292288458 0.0763550675374228 0.0658859509172242 0.0854260170816167 0.799013408909996 NA NA NA 0.812035766389903 99.727107917785 a9245 loss_cnaBRCA22_(SYNCRIP,ZNF292) 94 TGX221 PI3Kbeta 4 10 2.30258509299405 NA 3.91356066890607 3.7114115389944 0.202149129911666 0.982065949482134 1.40591790192183 0.153977676060325 0.205840687194443 0.143784448320444 0.799067889061793 NA NA NA 0.767911105225831 99.727107917785 a9246 BRCA1_mut 1502 Bicalutamide ANDR (androgen receptor) 4 41 2.30258509299405 NA 4.63011706135187 4.55129689603159 0.0788201653202796 0.583430105867949 0.588115704239994 0.134095788345615 0.135097871240329 0.134021527995306 0.799175728098351 NA NA NA 0.810592083814007 99.727107917785 a9247 gain_cnaBRCA15 344 THZ-2-49 CDK9 22 27 2.99573227355399 NA 1.84532309453948 1.73634691457478 0.108976179964694 1.66447872693253 1.31982452186747 0.0734466435849541 0.0654716568024432 0.0825686886090731 0.7992818166745 NA NA NA 0.804098019616365 99.727107917785 a9248 PIK3CA_mut 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 15 28 -1.38629436111989 0.693147180559945 -2.16937901606409 -2.24790336490252 0.0785243488384326 1.05944470585366 0.903790263898787 0.0818146921785141 0.0741184022201147 0.0868833754633435 0.799465073753837 NA NA NA 0.809605415473107 99.727107917785 a9249 loss_cnaBRCA34 1529 MLN4924 NEDD8-activating enzyme 4 33 0 NA 0.576452341874826 0.344095627558809 0.232356714316017 1.48300295009476 1.73483609301769 0.135508648524383 0.156679873294365 0.133935831316398 0.799488712955437 NA NA NA 0.785849606714109 99.727107917785 a9250 loss_cnaBRCA17 193 GW-2580 CSF1R (cFMS) 10 38 2.99573227355399 NA 5.51736474603632 5.44918468897303 0.06818005706329 0.509356258206839 0.798678108381838 0.0907983707467128 0.133855343808505 0.0853661272892858 0.799494776340537 NA NA NA 0.744628406265361 99.727107917785 a9251 gain_cnaBRCA64_(SDHC) 1529 MLN4924 NEDD8-activating enzyme 6 31 0 NA 0.533201928296705 0.337475919585799 0.195726008710906 2.46420517679421 1.55504974291273 0.1141458844863 0.0794276428578625 0.125864789601068 0.799505527884902 NA NA NA 0.857685837775963 99.727107917785 a9252 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 260 NG-25 MAP3K7 (TAK1) 15 34 2.32630161961136 NA 3.13733310361072 3.23967147867441 -0.102338375063693 1.06452787323088 1.37969385216792 0.0790949334086629 0.0961349886998186 0.0741746981787938 0.79970238206901 NA NA NA 0.779499408020098 99.727107917785 a9253 gain_cnaBRCA8_(CHD4,WNK1) 282 EKB-569 EGFR 4 43 0.916290731874155 2.99573227355399 1.31801106533444 1.60225874384921 -0.284247678514771 2.93531275182669 2.06126198974653 0.133404755856984 0.096837271714191 0.137899830263558 0.799728760155144 NA NA NA 0.860914170148506 99.727107917785 a9254 gain_cnaBRCA16 175 PAC-1 CASP3 agonist 16 32 0.940007258491471 NA 2.4654069514637 2.36936922508469 0.0960377263790044 1.14951196385576 1.26863142776471 0.0780125234733301 0.0835465218272882 0.0757018344943729 0.800022634272437 NA NA NA 0.793839676788126 99.727107917785 a9255 gain_cnaBRCA12_(TERT) 1262 UNC1215 LMBL3 10 36 0 NA 2.8001594205459 2.74567611242902 0.0544833081168812 0.516438096675157 0.617554886647784 0.0910690230084855 0.105498235834355 0.0882242360879498 0.800090156024309 NA NA NA 0.781191408654316 99.727107917785 a9256 gain_cnaBRCA61_(NOTCH2) 229 LY317615 PRKCB (PKCbeta) 3 46 2.99573227355399 2.32630161961136 3.12734492681516 3.37366382060502 -0.24631889378986 0.52764979317351 1.65673397811219 0.151604074818318 0.466822686138838 0.148677396035865 0.800280468241706 NA NA NA 0.554360068808227 99.727107917785 a9257 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 205 BMS-708163 g-secretase 9 39 2.32630161961136 0.940007258491471 4.84430261095859 4.90858188069525 -0.0642792697366543 0.485077864634026 0.718542486375399 0.0940180262426687 0.132513302344049 0.0894578552493164 0.800443147582634 NA NA NA 0.749910923491616 99.727107917785 a9258 gain_cnaBRCA30_(CRNKL1,FOXA2) 228 KIN001-102 AKT1 5 44 2.32630161961136 NA 1.79113834510909 1.96104055630636 -0.169902211197276 1.48338757346377 1.40981062989467 0.119968685983607 0.114536628347605 0.120514207791134 0.800447369152592 NA NA NA 0.817271216244021 99.727107917785 a9259 loss_cnaBRCA29_(MAP2K4) 301 PHA-793887 CDK-pan 7 41 2.32630161961136 NA 3.06906771553458 2.89720686551938 0.171860850015202 1.56606895633233 1.66568738720398 0.103966907018325 0.109740282712514 0.103177133557869 0.800456009211148 NA NA NA 0.796725279448406 99.727107917785 a9260 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1114 Cetuximab EGFR 8 37 4.18661983833127 NA 6.35464114218005 6.26700536063644 0.0876357815436126 0.982768482432784 0.863714333166807 0.099114386393744 0.0891723565724 0.101463850000377 0.800552393541638 NA NA NA 0.820356017606794 99.727107917785 a9261 loss_cnaBRCA29_(MAP2K4) 179 5-Fluorouracil DNA antimetabolite 7 42 3.46573590279973 NA 3.89664398034361 4.06561547267235 -0.16897149232873 1.53210162998898 1.64286914495539 0.10371770462751 0.110287391528945 0.102851461327627 0.800560912055561 NA NA NA 0.795627086870177 99.727107917785 a9262 gain_cnaBRCA15 262 VX-11e ERK 22 27 1.63315443905142 NA 3.83065137598533 3.73294277829227 0.0977085976930576 1.13784585946889 1.48265063666237 0.0729385029174314 0.0858715588583016 0.0659012954751171 0.800640183934781 NA NA NA 0.795321231453714 99.727107917785 a9263 BRCA1_mut 326 GSK690693 AKT 4 44 2.32630161961136 NA 3.17581773161302 2.91810193404541 0.257715797567615 2.12458369508388 1.9297378705982 0.132635293308138 0.121301786398884 0.133549639821146 0.800644978983454 NA NA NA 0.828152288087211 99.727107917785 a9264 loss_cnaBRCA38 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 39 1.38629436111989 0.693147180559945 3.58226517856761 3.42198091384582 0.160284264721794 0.535450095850783 1.07279699611024 0.152294049664346 0.299344917414043 0.14940782394335 0.800654212724655 NA NA NA 0.67771823814071 99.727107917785 a9265 POLR2B_mut 283 GSK2126458 PI3K, MTOR 3 45 -2.05572501506252 0.0237165266173161 -3.28872776323321 -3.03979991339201 -0.248927849841202 1.11411437059975 1.66541972617163 0.151296722778041 0.223431145320565 0.149468536927579 0.800833057550963 NA NA NA 0.745016179161924 99.727107917785 a9266 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1025 SB 216763 GSK3A, GSK3B 5 34 2.30258509299405 NA 4.9733153958425 4.87678573580349 0.096529660039006 0.61901427032821 0.812050890920696 0.121658238103084 0.155940928450365 0.118871441578694 0.800901834849967 NA NA NA 0.765579543834458 99.727107917785 a9267 gain_cnaBRCA64_(SDHC) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 8 41 3.68887945411394 NA 3.36078157702966 3.47871267339044 -0.117931096360782 1.22925950053466 1.19864249858923 0.0980103176848121 0.0959366971005626 0.0983872142858146 0.800927990191529 NA NA NA 0.808350286039121 99.727107917785 a9268 PTEN_mut 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 7 38 2.30258509299405 NA 3.29235953810952 3.1555920329755 0.136767505134023 1.48818491774343 1.28101158446773 0.10425266019031 0.0919022249878778 0.106765236780314 0.801115221386807 NA NA NA 0.825502054842784 99.727107917785 a9269 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1039 SL 0101-1 RSK, AURKB, PIM3 15 28 2.30258509299405 NA 4.70015697121904 4.62133088840767 0.0788260828113696 1.181769543744 0.842446003258579 0.0811195410359138 0.0667017382777006 0.0935681129787197 0.801131757312023 NA NA NA 0.820976099225121 99.727107917785 a9270 gain_cnaBRCA27_(CLTC,PPM1D) 1036 PLX4720 BRAF 10 33 2.30258509299405 NA 4.68159817108325 4.57086340900508 0.110734762078162 0.942485315963401 1.27708379422866 0.0913972048243614 0.117492294259216 0.0867090809378285 0.801382573091526 NA NA NA 0.768905463908078 99.727107917785 a9271 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1047 Nutlin-3a MDM2 6 37 2.07944154167984 1.38629436111989 4.30395424700959 4.19121326876922 0.112740978240373 0.927571484479737 1.02420104058985 0.111303975998911 0.121544247669071 0.110077000288385 0.801607377119593 NA NA NA 0.79329599589171 99.727107917785 a9272 gain_cnaBRCA58_(CCND1) 257 NPK76-II-72-1 PLK3 10 39 2.32630161961136 NA 3.59256909649678 3.44982983567658 0.142739260820201 1.65971034060302 1.57979904198295 0.0894686407615565 0.0860025134074535 0.0903527961638939 0.801825436503382 NA NA NA 0.810149325520206 99.727107917785 a9273 gain_cnaBRCA12_(TERT) 345 KIN001-270 CDK9 9 40 2.99573227355399 NA 5.05479155326924 5.11946596103082 -0.0646744077615793 0.668711777791667 0.700221702969403 0.0930621633543572 0.0967149224964424 0.0923627580912117 0.801949863282175 NA NA NA 0.799280026377563 99.727107917785 a9274 MLL3_mut 1013 Nilotinib ABL 3 37 0.693147180559945 NA 3.33832654489105 3.19192745031214 0.146399094578906 1.14288148638695 0.954851749886843 0.151605020213428 0.12809647922614 0.153321282174175 0.801978131163522 NA NA NA 0.847251040719076 99.727107917785 a9275 PTEN_mut 1054 PD-0332991 CDK4, CDK6 6 36 1.38629436111989 0.693147180559945 3.02376903285054 2.85942735589325 0.164341676957288 1.64253400856844 1.45199116753527 0.111255631394938 0.100053743849432 0.113183661603297 0.802098038008384 NA NA NA 0.824906267386274 99.727107917785 a9276 gain_cnaBRCA13_(FGFR1,WHSC1L1) 155 AP-24534 ABL 10 37 -0.669430653942629 NA 1.36468490619295 1.46716377570345 -0.1024788695105 1.31189192556187 1.09637978297071 0.0896783305686769 0.0781153291012207 0.0934702291142458 0.802482924682358 NA NA NA 0.824396240204677 99.727107917785 a9277 gain_cnaBRCA58_(CCND1) 256 JW-7-24-1 LCK 10 38 2.32630161961136 NA 1.92037432999098 1.81577828617881 0.104596043812168 0.838391919970393 1.23946355289246 0.0892576159993176 0.124757933993283 0.0843881561245414 0.802824116084106 NA NA NA 0.756410761232846 99.727107917785 a9278 loss_cnaBRCA34 1049 PD-173074 FGFR1, FGFR3 5 38 0.693147180559945 NA 3.05943286696965 2.92175492712679 0.137677939842864 0.471341015264554 1.20228789582781 0.119555235734848 0.292098364844377 0.114513287807883 0.802829159318307 NA NA NA 0.639750206951608 99.727107917785 a9279 loss_cnaBRCA20 303 PIK-93 PI4K, PI3K 3 46 2.99573227355399 NA 2.99257718311102 2.77841524422563 0.214161938885397 0.593611526884467 1.45763268888756 0.149603633798639 0.360777931670923 0.146924489631775 0.802859404769055 NA NA NA 0.625533133910621 99.727107917785 a9280 gain_cnaBRCA62 88 MS-275 HDAC 5 9 1.6094379124341 NA 0.97221650174073 1.2319255786075 -0.259709076866771 2.06628413038364 1.69060489238815 0.142349482003238 0.125688947152951 0.153619025968809 0.802882296619729 NA NA NA 0.81720481450634 99.727107917785 a9281 MACF1_mut 1373 Dabrafenib BRAF 3 43 2.30258509299405 NA 4.44539340735687 4.19848650764045 0.246906899716414 0.221282065201388 1.68495201836617 0.149923293046951 1.11580167824132 0.146536457433268 0.802933165829094 NA NA NA 0.396710532743549 99.727107917785 a9282 loss_cnaBRCA33 1007 Docetaxel Microtubules 5 40 -4.38202663467388 NA -4.42269385302279 -4.6078528808402 0.18515902781741 1.23729681243395 1.58376612116146 0.119088891352625 0.149648027827029 0.116910587581974 0.802962506462603 NA NA NA 0.77114972556948 99.727107917785 a9283 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1018 ABT-888 PARP1, PARP2 8 37 1.6094379124341 NA 4.45690311163853 4.39143793913186 0.0654651725066753 0.926208671999237 0.606818505414117 0.0978142382783923 0.0706808028102 0.107882623754197 0.803112675960706 NA NA NA 0.852910034512179 99.727107917785 a9284 loss_cnaBRCA57 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 5 40 2.30258509299405 NA 1.24789253394553 1.38000295050396 -0.132110416558426 1.34610578513347 1.08335225593197 0.118973337454752 0.0981426705222329 0.121945946791587 0.803149629382351 NA NA NA 0.841725514550347 99.727107917785 a9285 gain_cnaBRCA63 111 Salubrinal GADD34-PP1C 3 10 2.77258872223978 NA 3.3847941691719 3.19256858906116 0.192225580110744 1.50385537018511 1.04841220876948 0.167915205656067 0.127821853033036 0.183349238498814 0.803366471553378 NA NA NA 0.851185678250436 99.727107917785 a9286 loss_cnaBRCA60 328 SNX-2112 HSP90 3 45 0.940007258491471 NA 0.129745771646296 0.436406235766932 -0.306660464120636 1.83263919118235 2.06344407400528 0.149302901359437 0.16733270007327 0.148615835041939 0.803401830695114 NA NA NA 0.803384044408927 99.727107917785 a9287 gain_cnaBRCA14_(RAD21) 345 KIN001-270 CDK9 21 28 2.99573227355399 NA 5.07892319679131 5.12908483171566 -0.0501616349243541 0.835415853240425 0.569003476594281 0.0721783975496756 0.0600439107419213 0.0881569919828821 0.803651275720838 NA NA NA 0.814107785973077 99.727107917785 a9288 gain_cnaBRCA48 277 ABT-869 VEGFR and PDGFR family 5 43 0.0237165266173161 NA 2.74174091411834 2.68518724022777 0.0565536738905688 0.417371696172477 0.484155651260356 0.118135589332978 0.13549954251617 0.116808868683755 0.803683078035363 NA NA NA 0.788739644955078 99.727107917785 a9289 BRCA2_mut 333 T0901317 LXR 6 42 2.32630161961136 NA 4.66194507593058 4.74593493890101 -0.0839898629704283 0.819952075116262 0.763406369974561 0.109112620286095 0.102432648833189 0.110019861339678 0.803694019251405 NA NA NA 0.820409680752111 99.727107917785 a9290 gain_cnaBRCA10_(MDM2,NUP107) 1006 Cytarabine DNA synthesis 3 42 0.693147180559945 NA 0.993796101638724 1.22387164430506 -0.230075542666341 0.842918086409056 1.56578036666937 0.149428560152098 0.272951246836443 0.146939856677181 0.803745783764076 NA NA NA 0.69964983387622 99.727107917785 a9291 gain_cnaBRCA58_(CCND1) 1023 GW 441756 NTRK1 9 36 0.693147180559945 NA 2.26168005339372 2.38368847526996 -0.122008421876238 0.928231842713574 1.38403500002657 0.0930448509995378 0.131441754378476 0.0881541448546429 0.804034889208714 NA NA NA 0.755516659296114 99.727107917785 a9292 loss_cnaBRCA28_(GPS2) 283 GSK2126458 PI3K, MTOR 4 44 -2.05572501506252 0.0237165266173161 -3.25168862342504 -3.03750965678727 -0.214178966637779 0.780995291430992 1.68921423789906 0.130173401884739 0.27423848643869 0.126792068070751 0.804266965118482 NA NA NA 0.662061335954927 99.727107917785 a9293 gain_cnaBRCA19 1042 BIRB 0796 p38, JNK2 3 40 2.30258509299405 NA 4.23732606059903 4.3762907666594 -0.138964706060362 0.872075556565759 0.933894242316071 0.14926809498092 0.159349387807183 0.148801330775664 0.804328889166 NA NA NA 0.81252605854717 99.727107917785 a9294 loss_cnaBRCA60 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 3 45 2.77258872223978 NA -0.239149639481039 -0.449685705675609 0.21053606619457 0.92348060422339 1.43601688323776 0.148516762689568 0.227981037427009 0.146611135740882 0.804415270557253 NA NA NA 0.740897095666852 99.727107917785 a9295 PIK3CA_mut 1019 Bosutinib SRC, ABL, TEC 16 29 0.693147180559945 NA 2.70962875178398 2.6366508327726 0.0729779190113726 1.08124175035689 0.856470276038058 0.0775538550302255 0.0674945441084609 0.0852077661690268 0.804521296161112 NA NA NA 0.817856771116918 99.727107917785 a9296 loss_cnaBRCA23 179 5-Fluorouracil DNA antimetabolite 3 46 3.46573590279973 NA 4.26828070934206 4.02668512144821 0.241595587893849 0.0778896016341877 1.66492297193626 0.148291549774679 3.10176946376635 0.145109168391665 0.80455212862654 NA NA NA 0.337977777498012 99.727107917785 a9297 gain_cnaBRCA15 291 KIN001-266 MAP3K8 (COT) 22 27 2.99573227355399 NA 3.82540698836756 3.74052341833484 0.0848835700327268 1.38883716696618 0.996408419773271 0.0714580089835389 0.0611184464613293 0.0851895350824532 0.804601391443732 NA NA NA 0.811176697518006 99.727107917785 a9298 loss_cnaBRCA57 204 Tipifarnib Farnesyl-transferase (FNTA) 5 43 2.77258872223978 NA 1.78053442983838 1.60130700397376 0.179227425864619 0.803071238638756 1.57609644464539 0.117563383874998 0.223177493155425 0.113716027006802 0.804614052353838 NA NA NA 0.688939344457851 99.727107917785 a9299 gain_cnaBRCA61_(NOTCH2) 226 GSK1070916 AURKB 3 46 0.940007258491471 2.32630161961136 2.13118050670482 2.42173687458997 -0.290556367885149 0.936613487203094 1.99438170059194 0.148165346829889 0.310220140810491 0.145687441776522 0.804714993468057 NA NA NA 0.666010832176857 99.727107917785 a9300 loss_cnaBRCA7_(FAS,PTEN) 301 PHA-793887 CDK-pan 4 44 2.32630161961136 NA 3.11889634804643 2.9043947750648 0.214501572981632 0.97673203824385 1.69020357352234 0.129758259486556 0.219611484606672 0.12690872054815 0.804878161541402 NA NA NA 0.71354826574544 99.727107917785 a9301 gain_cnaBRCA14_(RAD21) 185 OSI-906 IGF1R 21 27 0.940007258491471 NA 2.93967039987612 2.85757175582377 0.0820986440523477 1.15950511429343 1.11704206892166 0.0722890642265883 0.0708049003323082 0.0734964656537975 0.80489013288462 NA NA NA 0.80589323309957 99.727107917785 a9302 gain_cnaBRCA16 275 I-BET BRD2, BRD3, BRD4 16 33 2.99573227355399 NA 3.96922051905666 4.07274495764699 -0.10352443859033 1.52273097920934 1.28983421906782 0.0756494324024494 0.0679860329919105 0.0802618174180155 0.80496296415199 NA NA NA 0.816651147810692 99.727107917785 a9303 gain_cnaBRCA31 83 JW-7-52-1 MTOR 3 9 0.182321556793955 NA -2.30553284429728 -1.92470948055895 -0.38082336373833 1.86675097165857 2.34188690765985 0.168888271209417 0.204003302807967 0.162613900138701 0.805143379684356 NA NA NA 0.787869600535533 99.727107917785 a9304 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1067 CCT007093 PPM1D 7 39 1.88706964903238 NA 3.99989944282758 4.10102487692038 -0.101125434092797 0.398383185198469 1.05648195097756 0.101861835407766 0.253839614346218 0.095719036183464 0.805173019420799 NA NA NA 0.659142150915614 99.727107917785 a9305 ARID1A_mut 274 PXD101, Belinostat HDAC 5 43 2.99573227355399 NA 0.829436690063298 0.653139003628957 0.176297686434342 1.66709242048225 1.48982608492299 0.117058170048535 0.105751597372954 0.118334407095211 0.805436269755891 NA NA NA 0.830411875719831 99.727107917785 a9306 ASH1L_mut 1009 ATRA Retinoic acid and retinoid X receptor agonist 3 42 2.30258509299405 NA 3.9448350034173 4.117480576455 -0.172645573037691 0.925241630318559 1.17640609614929 0.148076129765359 0.186595119999356 0.146756782035395 0.805484995892243 NA NA NA 0.783374571337284 99.727107917785 a9307 loss_cnaBRCA17 262 VX-11e ERK 11 38 1.63315443905142 NA 3.68877260543859 3.80229701646695 -0.113524411028351 1.16205647142689 1.38373927733498 0.0847419417339123 0.0976926800200637 0.0820417638552507 0.805593501193189 NA NA NA 0.787929141057584 99.727107917785 a9308 loss_cnaBRCA34 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 3 23 2.30258509299405 NA 4.54986887671021 4.70352084417241 -0.153651967462204 0.453812379861607 1.04188055106605 0.152721850103011 0.338580378765914 0.147475607741201 0.805637232409225 NA NA NA 0.669041758928836 99.727107917785 a9309 gain_cnaBRCA47_(EGFR) 1066 AZD6482 PI3Kbeta 6 37 1.6094379124341 NA 1.83124963701796 1.98923163813547 -0.157982001117511 1.00368997385251 1.50109242980409 0.108983139042686 0.157401194824255 0.105244685790687 0.805657394990562 NA NA NA 0.748651163652271 99.727107917785 a9310 loss_cnaBRCA22_(SYNCRIP,ZNF292) 192 LFM-A13 BTK 18 30 2.77258872223978 NA 4.83430921342016 4.77216667076712 0.0621425426530395 1.05913153329194 0.684456392653572 0.0737543165782378 0.0586731116010597 0.0907910910322845 0.805715383671694 NA NA NA 0.82561239227939 99.727107917785 a9311 gain_cnaBRCA27_(CLTC,PPM1D) 1373 Dabrafenib BRAF 10 36 2.30258509299405 NA 4.10062516898046 4.24624578780015 -0.14562061881969 0.819708615197342 1.79917677074499 0.088419824652416 0.177649247695942 0.0809373604570229 0.805783538002636 NA NA NA 0.715629884752761 99.727107917785 a9312 gain_cnaBRCA14_(RAD21) 1053 MK-2206 AKT1, AKT2 19 23 1.38629436111989 0.693147180559945 1.32422326432214 1.4514207911897 -0.127197526867558 1.77792138251884 1.55272114482046 0.0767243322884424 0.0715428298001309 0.0819191052378349 0.805798733148891 NA NA NA 0.808417685230342 99.727107917785 a9313 POLR2B_mut 258 STF-62247 stimulates autophagy 3 46 2.32630161961136 NA 4.76469832729407 4.62211320395307 0.142585123341001 0.361818798333383 0.98615791792692 0.147324554709048 0.394078815135585 0.144586501562286 0.80580025825563 NA NA NA 0.602865355255456 99.727107917785 a9314 gain_cnaBRCA58_(CCND1) 292 Masitinib KIT 10 38 2.99573227355399 NA 4.08663435452166 3.99024659898743 0.0963877555342227 1.16191946341216 1.08069256526147 0.0878602094288957 0.0829556252127533 0.08919072697692 0.805846903651902 NA NA NA 0.816425145792531 99.727107917785 a9315 loss_cnaBRCA28_(GPS2) 281 CH5424802 ALK 4 44 1.63315443905142 NA 3.44845102532582 3.58676586247654 -0.138314837150722 0.734606726499931 1.09201866758082 0.128983339393303 0.188284196375018 0.126659773552346 0.80601937261537 NA NA NA 0.747224330343662 99.727107917785 a9316 gain_cnaBRCA16 1046 681640 WEE1, CHEK1 13 23 0.693147180559945 NA 2.69283427688273 2.60042479174603 0.0924094851367054 1.25867885440002 0.962515857678712 0.0858513542686852 0.0734178419011848 0.0960082729021923 0.806072693229843 NA NA NA 0.820813769636361 99.727107917785 a9317 loss_cnaBRCA42 260 NG-25 MAP3K7 (TAK1) 3 46 2.32630161961136 NA 3.0297067803333 3.21999361930633 -0.190286838973025 0.682112232140561 1.31452457684643 0.147061672292512 0.278967052644517 0.144757155799648 0.806139656951736 NA NA NA 0.693223563563251 99.727107917785 a9318 loss_cnaBRCA17 87 GW843682X PLK1 3 9 -1.36257783450257 NA -2.16587224145783 -1.83097890727166 -0.334893334186169 2.08681889373103 1.97044237595334 0.167928533631367 0.160480305786101 0.169958451093572 0.806225187722459 NA NA NA 0.821619893086623 99.727107917785 a9319 loss_cnaBRCA22_(SYNCRIP,ZNF292) 34 Imatinib ABL, KIT, PDGFR 4 10 0.693147180559945 NA 2.72586780086231 2.7980145373232 -0.0721467364608905 0.075433538583587 0.559872325007207 0.148349829769182 0.956427841190899 0.128862837540616 0.806244056092404 NA NA NA 0.698786520737384 99.727107917785 a9320 loss_cnaBRCA57 346 THZ-2-102-1 CDK7 5 43 0.916290731874155 2.99573227355399 -1.06774576961543 -1.36625204205826 0.298506272442825 1.73509961945526 2.62741227687422 0.116504525318335 0.172039846643816 0.113612269787348 0.806337561937684 NA NA NA 0.743480657439539 99.727107917785 a9321 gain_cnaBRCA9_(KRAS) 291 KIN001-266 MAP3K8 (COT) 4 45 2.99573227355399 NA 3.63855854950526 3.79108559646902 -0.152527046963765 1.28191660804428 1.18121440144405 0.128400870993244 0.118983595349828 0.129127317426285 0.806678811153179 NA NA NA 0.831388309872369 99.727107917785 a9322 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1061 SB590885 BRAF 5 37 1.6094379124341 NA 3.89855812023777 4.02722974724954 -0.128671627011771 0.478787860974095 1.14481394451744 0.117340236228359 0.268744547428559 0.112395230358596 0.806734106467546 NA NA NA 0.659924585628328 99.727107917785 a9323 loss_cnaBRCA7_(FAS,PTEN) 1052 RO-3306 CDK1 4 39 1.6094379124341 NA 3.38379305080502 3.54022518730347 -0.156432136498448 1.00003663136184 1.22563719866351 0.129223347120683 0.156426406386154 0.12763331324231 0.806807709939783 NA NA NA 0.785398865927266 99.727107917785 a9324 loss_cnaBRCA29_(MAP2K4) 268 YM155 BIRC5 (Survivin) 7 42 1.63315443905142 NA -3.4571124497034 -3.61865559402238 0.161543144318973 1.69017080430016 1.59690142912986 0.100392902638028 0.0955779995181386 0.101160373065103 0.806821584872732 NA NA NA 0.81949170062429 99.727107917785 a9325 gain_cnaBRCA8_(CHD4,WNK1) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 39 1.38629436111989 0.693147180559945 3.28930539603047 3.44451628173329 -0.155210885702821 1.24843346203043 1.04118668740227 0.1474661600273 0.124324515821923 0.149071139288255 0.80684196526504 NA NA NA 0.851533749892311 99.727107917785 a9326 PTEN_mut 330 XMD13-2 RIPK 9 39 2.32630161961136 NA 3.63050992061752 3.74190847287406 -0.111398552256536 1.04083728339758 1.26032575240585 0.0909389202595816 0.107027826571412 0.0883886979567673 0.806843007738223 NA NA NA 0.785421048345151 99.727107917785 a9327 loss_cnaBRCA33 1066 AZD6482 PI3Kbeta 5 38 1.6094379124341 NA 2.11711035627189 1.94746096452002 0.169649391751873 1.67134568932677 1.42357648767025 0.117030690390642 0.101504669462012 0.119171251577435 0.806906471910047 NA NA NA 0.837242113409593 99.727107917785 a9328 loss_cnaBRCA23 229 LY317615 PRKCB (PKCbeta) 3 46 2.99573227355399 2.32630161961136 3.58196707596321 3.34401455000841 0.237952525954797 0.582901652133039 1.65598729789241 0.146448018064743 0.408220709418212 0.143692241032067 0.806932071982767 NA NA NA 0.593924644954954 99.727107917785 a9329 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 15 28 0.693147180559945 NA 2.85905710132659 2.93486240361753 -0.0758053022909406 1.07126064189022 0.902113816232315 0.0787001533079362 0.0707627064102568 0.0840307519150322 0.806939717736445 NA NA NA 0.817438299988886 99.727107917785 a9330 gain_cnaBRCA19 300 CX-5461 RNA Pol I 4 45 2.32630161961136 NA 3.70992412352707 3.93036006386343 -0.220435940336357 1.34283435499957 1.74230295158502 0.128191746468287 0.164157209350239 0.126519868508413 0.806987252625129 NA NA NA 0.774876531593013 99.727107917785 a9331 gain_cnaBRCA8_(CHD4,WNK1) 298 OSI-930 KIT, VEGFR, PDGFR 4 44 2.32630161961136 NA 3.80993014657769 3.92277067370264 -0.112840527124954 1.22436046882346 0.850704999548804 0.128238973547738 0.0921628311255321 0.13264354527692 0.807115988955346 NA NA NA 0.8674453508238 99.727107917785 a9332 loss_cnaBRCA29_(MAP2K4) 1069 EHT 1864 Rac GTPases 7 39 2.30258509299405 NA 3.48753799770162 3.57468286876852 -0.0871448710668945 1.17319598801991 0.805608410610553 0.100747627879714 0.0742798918141336 0.108172742388389 0.807260508113462 NA NA NA 0.855642441825174 99.727107917785 a9333 gain_cnaBRCA64_(SDHC) 222 BX-912 PDPK1 (PDK1) 8 41 2.32630161961136 NA 3.76303846034632 3.90734025685 -0.144301796503682 1.90329822128242 1.44496915125112 0.0948104261704142 0.0758167032838674 0.0998649669293899 0.807293219030788 NA NA NA 0.843594936220246 99.727107917785 a9334 gain_cnaBRCA58_(CCND1) 1006 Cytarabine DNA synthesis 9 36 0.693147180559945 NA 1.09592305699402 1.23668582924397 -0.140762772249948 0.905643660474819 1.65083051031227 0.0914195616675545 0.155428429959028 0.0852678523753004 0.807387725084194 NA NA NA 0.73348667261061 99.727107917785 a9335 gain_cnaBRCA58_(CCND1) 1032 Afatinib ERBB2, EGFR 9 36 -0.693147180559945 NA 0.155520302306729 0.324209547417243 -0.168689245110514 1.84936081424396 1.84447781190084 0.0914112984055139 0.0912148910105872 0.0914563699395603 0.807404780923551 NA NA NA 0.810583837953737 99.727107917785 a9336 gain_cnaBRCA31 269 NSC-207895 MDM4 16 33 2.99573227355399 NA 4.66408991098248 4.57477996968287 0.0893099412996179 1.19014407483726 1.19872948136633 0.074674104099963 0.075041285494641 0.0745038331732872 0.807426214750717 NA NA NA 0.807549553034574 99.727107917785 a9337 loss_cnaBRCA23 190 Bleomycin DNA damage 3 45 4.15888308335967 NA 1.69986150661194 2.10363499964392 -0.403773493031977 2.04884960460149 2.79065210962113 0.146159975834534 0.197073270837033 0.144687864044363 0.807455518488907 NA NA NA 0.772227884201839 99.727107917785 a9338 gain_cnaBRCA10_(MDM2,NUP107) 1046 681640 WEE1, CHEK1 3 33 0.693147180559945 NA 2.77984202650639 2.62051787060955 0.159324155896845 1.32434365729283 1.058982784637 0.148015112114914 0.120304239023977 0.150450185034366 0.807579523258655 NA NA NA 0.856414572404915 99.727107917785 a9339 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1013 Nilotinib ABL 6 34 0.693147180559945 NA 3.29203644361155 3.18717872454568 0.104857719065867 1.01842811992576 0.957466426786538 0.1085812309661 0.102960353327156 0.109515818134524 0.807612566124374 NA NA NA 0.821593564475984 99.727107917785 a9340 gain_cnaBRCA16 257 NPK76-II-72-1 PLK3 16 33 2.32630161961136 NA 3.3988730875525 3.51779045925802 -0.118917371705521 1.95958664229492 1.39240016800427 0.0745340875103891 0.060684926677319 0.0854045944823214 0.807779997593367 NA NA NA 0.829718691577785 99.727107917785 a9341 loss_cnaBRCA38 1241 CHIR-99021 GSK3B 3 43 2.30258509299405 NA 4.36595707167876 4.2221054660317 0.143851605647058 0.817078360476251 0.992023206409425 0.146079960368994 0.17605607075827 0.145008306980763 0.807881549641502 NA NA NA 0.794478358661694 99.727107917785 a9342 POLR2B_mut 1373 Dabrafenib BRAF 3 43 2.30258509299405 NA 3.99029630886928 4.23023746800005 -0.239941159130772 2.0313735384774 1.62638324746263 0.145687850280266 0.118117694548004 0.147530515642676 0.80838685185311 NA NA NA 0.858475976799024 99.727107917785 a9343 PTEN_mut 254 AC220 FLT3 9 39 0.0237165266173161 NA 2.15861409353664 2.23879600573953 -0.0801819122028884 0.859356171515882 0.895578727162164 0.0901543204777402 0.0933046330038564 0.0895308360628018 0.808475939480374 NA NA NA 0.806471609394431 99.727107917785 a9344 loss_cnaBRCA18 29 AZ628 BRAF 6 8 1.38629436111989 NA 2.64737450882546 2.36512236769522 0.282252141130238 0.885839099083144 2.65875103142089 0.133792512718946 0.318626871880427 0.106159673393487 0.808527193478496 NA NA NA 0.7856615608328 99.727107917785 a9345 TP53_mut 291 KIN001-266 MAP3K8 (COT) 38 11 2.99573227355399 NA 3.80087160159226 3.70181501623827 0.0990565853539866 1.26373101025803 0.850521119542666 0.0833870686515665 0.0783842325225217 0.116465756202798 0.8086389972253 NA NA NA 0.765447985428089 99.727107917785 a9346 gain_cnaBRCA14_(RAD21) 1047 Nutlin-3a MDM2 19 24 2.07944154167984 1.38629436111989 4.24921861740893 4.17347761232287 0.0757410050860647 0.87987844934958 1.10601007590872 0.0747713528667184 0.0860812139927437 0.068481297535951 0.808839045641716 NA NA NA 0.803761127049169 99.727107917785 a9347 loss_cnaBRCA34 203 BMS-345541 IKBKB 5 44 2.77258872223978 NA 3.4277095955554 3.54422107156037 -0.116511476004969 0.450222704548343 1.05228844041938 0.114784181381202 0.258786318033099 0.110721995538158 0.808895094964432 NA NA NA 0.65901690557701 99.727107917785 a9348 loss_cnaBRCA34 258 STF-62247 stimulates autophagy 5 44 2.32630161961136 NA 4.73044680154024 4.61952428081869 0.110922520721545 0.710577808774903 0.988385963529141 0.114606885192122 0.156101864358506 0.112225916610029 0.809184397812435 NA NA NA 0.762809727558467 99.727107917785 a9349 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 287 KIN001-244 PDPK1 (PDK1) 7 42 2.99573227355399 NA 3.5587460301116 3.46466604381478 0.0940799862968191 1.35579005406109 0.873941664879141 0.0991177855991997 0.0693912645361391 0.107650190027076 0.8092260752992 NA NA NA 0.864210734902089 99.727107917785 a9350 NF1_mut 1021 Axitinib PDGFR, KIT, VEGFR 4 41 0.693147180559945 NA 2.32573962500218 2.47567988361026 -0.149940258608078 1.00331013869546 1.19121637504721 0.127167293880787 0.149445573033912 0.12587155595652 0.809339576172594 NA NA NA 0.793608766847923 99.727107917785 a9351 gain_cnaBRCA63 1262 UNC1215 LMBL3 6 40 0 NA 2.81280100975434 2.74922820485944 0.063572804894902 1.1776425743436 0.475459320126101 0.106254909556907 0.0539831068270751 0.133708189541939 0.809363071726912 NA NA NA 0.900919368101205 99.727107917785 a9352 gain_cnaBRCA8_(CHD4,WNK1) 206 Ruxolitinib JAK1, JAK2, TYK2 4 45 1.65632149833295 0.0237165266173161 4.44673545927968 4.36346267393546 0.0832727853442243 0.658710628911047 0.657803720036341 0.126581000660137 0.126417855867739 0.126592147182786 0.809364005013656 NA NA NA 0.821860342568549 99.727107917785 a9353 gain_cnaBRCA15 1494 SN-38 TOP1 23 25 -2.99573227355399 NA -3.24191910568025 -3.36070836182746 0.118789256147208 2.01319630330716 1.33893197383202 0.0700737567412886 0.0590053021417077 0.0887194110446351 0.809446254905808 NA NA NA 0.812726952678236 99.727107917785 a9354 BRCA1_mut 1114 Cetuximab EGFR 4 41 4.18661983833127 NA 6.38496359934634 6.27259690447813 0.112366694868217 0.356005978607499 0.911608556521684 0.127076066203163 0.315631482672662 0.123262001068705 0.809473630393755 NA NA NA 0.635561470875633 99.727107917785 a9355 NF1_mut 173 FH535 unknown 5 43 3.46573590279973 NA 1.44080410113105 1.58836946194915 -0.1475653608181 0.853109810898629 1.32308461826883 0.114477170944887 0.172973465939467 0.111531310076886 0.809640202419211 NA NA NA 0.743200722817605 99.727107917785 a9356 CDH1_mut 1026 17-AAG HSP90 4 39 0 NA -0.68837479861717 -0.917522737570331 0.229147938953161 2.23068907726815 1.76188104869558 0.12728119426852 0.102725180881681 0.130058688764949 0.80965308126269 NA NA NA 0.853468410474711 99.727107917785 a9357 loss_cnaBRCA33 88 MS-275 HDAC 5 9 1.6094379124341 NA 1.30011641969362 1.04975895752256 0.250357462171064 1.77563961662431 1.84888572602492 0.137197427589439 0.140995650146071 0.135409916712014 0.809859637421375 NA NA NA 0.809094541031368 99.727107917785 a9358 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 9 MG-132 Proteasome 4 10 0 NA 0.498698567150199 0.261306392946418 0.237392174203781 1.96015592527567 1.5065633664631 0.145476494242292 0.121108821570098 0.157571981031968 0.809915060876901 NA NA NA 0.837076149764527 99.727107917785 a9359 POLR2B_mut 211 TL-2-105 CRAF 3 46 2.32630161961136 1.63315443905142 3.75930491606408 3.91722213785374 -0.157917221789658 0.629085234971555 1.11191245836551 0.14412327206447 0.251026749653086 0.142023070792634 0.809935877966369 NA NA NA 0.719304674902753 99.727107917785 a9360 gain_cnaBRCA13_(FGFR1,WHSC1L1) 300 CX-5461 RNA Pol I 11 38 2.32630161961136 NA 3.80204478350002 3.94430017761743 -0.142255394117406 1.78306501402685 1.70206183274357 0.0827250866535023 0.0797813837399787 0.0835782762886491 0.810128098482187 NA NA NA 0.816963410751327 99.727107917785 a9361 POLR2B_mut 1067 CCT007093 PPM1D 3 43 1.88706964903238 NA 4.21950898018069 4.07629626416618 0.143212716014505 0.513603058798906 1.00997064307877 0.144250320004916 0.278839297315356 0.141798889894401 0.810240065881445 NA NA NA 0.695336479666606 99.727107917785 a9362 gain_cnaBRCA62 64 CMK RSK 4 8 1.38629436111989 NA 2.0791657689426 2.26665182942823 -0.187486060485632 1.02690595611411 1.32400971789314 0.150911041934978 0.182573739464024 0.141604746514983 0.810329108751486 NA NA NA 0.794319733549939 99.727107917785 a9363 ARID1A_mut 206 Ruxolitinib JAK1, JAK2, TYK2 5 44 1.65632149833295 0.0237165266173161 4.30297646708676 4.37790635974502 -0.0749298926582593 0.492987457052965 0.671147404964362 0.113898423288657 0.151991478862735 0.111644464545368 0.810340698027862 NA NA NA 0.768131143415951 99.727107917785 a9364 gain_cnaBRCA61_(NOTCH2) 201 Epothilone B Microtubules 3 45 -3.44201937618241 NA -3.99072710889689 -4.25209331249815 0.261366203601262 2.28283952276915 1.79304069073289 0.143838283829352 0.114491711307073 0.145767022997359 0.810453434585719 NA NA NA 0.862611362551997 99.727107917785 a9365 gain_cnaBRCA48 205 BMS-708163 g-secretase 5 43 2.32630161961136 0.940007258491471 4.96634055614935 4.88841195499989 0.0779286011494644 0.661099772094869 0.685855926959608 0.113974226669705 0.117877216781556 0.113622406814972 0.810460063456727 NA NA NA 0.813532577190927 99.727107917785 a9366 gain_cnaBRCA58_(CCND1) 1239 YK 4-279 RNA helicase A 8 34 2.30258509299405 NA 2.11373061672464 1.98998164801401 0.123748968710625 1.25447149302016 1.31537072612017 0.0948327154722914 0.0986462979821865 0.0940791567375352 0.810529352065456 NA NA NA 0.808206269580933 99.727107917785 a9367 gain_cnaBRCA61_(NOTCH2) 193 GW-2580 CSF1R (cFMS) 3 45 2.99573227355399 NA 5.56458357976963 5.45664255337844 0.1079410263912 0.099393800780673 0.767538512449001 0.143738625681188 1.08599354832388 0.140632716978318 0.810582184169603 NA NA NA 0.406020419355321 99.727107917785 a9368 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 256 JW-7-24-1 LCK 14 34 2.32630161961136 NA 1.77408285471908 1.86371053554816 -0.0896276808290717 1.30483101695544 1.11520419067371 0.0764800734524246 0.068689109673527 0.0803688522502114 0.810748276958676 NA NA NA 0.823864198764585 99.727107917785 a9369 gain_cnaBRCA64_(SDHC) 295 NVP-BHG712 EPHB4 8 41 2.32630161961136 NA 3.79044875224649 3.90549059378291 -0.115041841536418 2.23537072778164 0.961489629237014 0.0929756515902323 0.0514643231687051 0.1196495916734 0.810948935536723 NA NA NA 0.890046936475292 99.727107917785 a9370 loss_cnaBRCA57 1058 GDC0941 PI3K (class 1) 5 38 1.38629436111989 0.693147180559945 1.48740061897987 1.32739756304091 0.160003055938962 1.55343080110325 1.37941918526083 0.11450462316508 0.10299979620935 0.115993062622735 0.810991695583465 NA NA NA 0.835371729337119 99.727107917785 a9371 gain_cnaBRCA62 231 FMK RSK 10 39 2.99573227355399 2.32630161961136 5.54871769275775 5.59961739085718 -0.0508996980994318 1.00440215344058 0.450057143086998 0.0851952082136696 0.0506766118780959 0.113096078756365 0.811101962550955 NA NA NA 0.878938518678435 99.727107917785 a9372 gain_cnaBRCA31 235 QL-XII-47 BTK, BMX 16 33 2.32630161961136 NA 1.63351123821565 1.74422726772 -0.110716029504357 1.3828354780074 1.57230634220236 0.0731081378000101 0.0800644988251919 0.0704163218913659 0.811385273183672 NA NA NA 0.803276579862607 99.727107917785 a9373 gain_cnaBRCA62 1066 AZD6482 PI3Kbeta 6 37 1.6094379124341 NA 2.09881278998469 1.94584301873546 0.152969771249236 1.55223609111434 1.43484276446718 0.105520548404898 0.0985480057607864 0.106610825267701 0.811709880353869 NA NA NA 0.828009641807489 99.727107917785 a9374 CDH1_mut 1261 rTRAIL TR10A (DR4), TR10B (DR5) 5 42 -2.30258509299405 NA -0.0347921321077594 -0.153202681858574 0.118410549750814 1.04848951385982 1.04416230732588 0.113360598774248 0.11293441487546 0.113402436498656 0.811713069731045 NA NA NA 0.820734161602808 99.727107917785 a9375 loss_cnaBRCA36_(FAT1,IRF2) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 9 40 3.68887945411394 NA 3.54626360963463 3.43992749346334 0.106336116171287 1.21137589901591 1.201685521861 0.088367440324838 0.0877812710799934 0.0884891381620442 0.8117423112954 NA NA NA 0.815744339613383 99.727107917785 a9376 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1019 Bosutinib SRC, ABL, TEC 6 39 0.693147180559945 NA 2.74827250114768 2.6494179274888 0.0988545736588882 0.680178917703659 0.970164059387328 0.10504739970118 0.145336133017221 0.101894697811539 0.811821256885822 NA NA NA 0.763515160435023 99.727107917785 a9377 PTEN_mut 1009 ATRA Retinoic acid and retinoid X receptor agonist 7 38 2.30258509299405 NA 4.20297568649638 4.08810156357597 0.114874122920408 1.05806267801231 1.18255109680297 0.0985216221219929 0.108570243812221 0.0971409381218033 0.811830121248332 NA NA NA 0.80146582091738 99.727107917785 a9378 loss_cnaBRCA34 151 QS11 ARFGAP 5 43 2.32630161961136 NA 3.60945012330007 3.77800800548298 -0.168557882182907 1.35987553716869 1.50300640820366 0.113042204932991 0.123950962846093 0.112147148051326 0.811979940819628 NA NA NA 0.805305191854526 99.727107917785 a9379 BRCA2_mut 1024 CEP-701 FLT3, JAK2, NTRK1, RET 5 40 0.693147180559945 NA 0.77150764002604 0.607326582646914 0.164181057379127 1.39046406236326 1.45202393179101 0.113509508862761 0.118076447873152 0.113070489944761 0.812010663178498 NA NA NA 0.813942693040735 99.727107917785 a9380 loss_cnaBRCA34 1149 TW 37 BCL2, BCL2L1 3 40 1.6094379124341 NA 0.0251238406080807 -0.154947348526619 0.180071189134699 1.44158876614148 1.24655175499664 0.143281149674316 0.124911620681308 0.144455445522344 0.812021603173039 NA NA NA 0.850947833919627 99.727107917785 a9381 NF1_mut 203 BMS-345541 IKBKB 5 44 2.77258872223978 NA 3.42949410865774 3.54401828598055 -0.114524177322814 0.37114596998422 1.05517812229934 0.112823943208115 0.308569098373028 0.108535397865579 0.812095201410026 NA NA NA 0.6263102084608 99.727107917785 a9382 PTEN_mut 1049 PD-173074 FGFR1, FGFR3 6 37 0.693147180559945 NA 2.83341510868656 2.95468543009586 -0.121270321409304 0.916896150965459 1.18058771316 0.105299789986265 0.132261784806939 0.102720297744509 0.812096158455135 NA NA NA 0.780981436524764 99.727107917785 a9383 BRCA1_mut 256 JW-7-24-1 LCK 4 44 2.32630161961136 NA 1.70352156615129 1.84975527068407 -0.146233704532784 1.15060526168246 1.17339320951472 0.124781244796616 0.127092852260171 0.124624638481812 0.812215094124078 NA NA NA 0.82126962696955 99.727107917785 a9384 loss_cnaBRCA36_(FAT1,IRF2) 1375 Temozolomide DNA akylating agent 9 37 3.40119738166216 NA 5.84989180658524 5.91234504783496 -0.0624532412497194 0.45700461626504 0.746890915407457 0.0888216658731765 0.136657790812116 0.0836176206744311 0.812230504294242 NA NA NA 0.752905950165858 99.727107917785 a9385 gain_cnaBRCA48 1043 JNK Inhibitor VIII JNK 4 39 2.30258509299405 NA 4.71175474000314 4.80610825206603 -0.0943535120628978 0.691155303749568 0.756381324752469 0.1255033741044 0.136515644965789 0.124743312632389 0.812259985555745 NA NA NA 0.810087406504428 99.727107917785 a9386 gain_cnaBRCA10_(MDM2,NUP107) 1038 NU-7441 PRKDC (DNAPK) 3 40 0.693147180559945 NA 3.01949206062193 2.88336798730173 0.136124073320198 0.446555537927929 0.971035179701568 0.142960883267741 0.304831228724271 0.140184491937804 0.81243365623594 NA NA NA 0.675759944941712 99.727107917785 a9387 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1529 MLN4924 NEDD8-activating enzyme 6 31 0 NA 0.522387377585558 0.339569058433118 0.18281831915244 2.27083673852784 1.6036208208346 0.106605498421567 0.0805070289953823 0.114003458159949 0.812483767946057 NA NA NA 0.856829759605308 99.727107917785 a9388 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1239 YK 4-279 RNA helicase A 9 33 2.30258509299405 NA 2.10561742404134 1.98844436817883 0.117173055862511 1.81281427037291 1.14324400131396 0.0897920110999344 0.0646359959635623 0.102491730311151 0.812498162973708 NA NA NA 0.85762985963845 99.727107917785 a9389 loss_cnaBRCA42 329 QL-XI-92 DDR1 3 45 2.32630161961136 NA 4.12625078443558 4.26180738577646 -0.135556601340885 0.848000544088862 0.957763010721024 0.14220413672075 0.159854380148464 0.141534596579205 0.812565275418425 NA NA NA 0.811903790912683 99.727107917785 a9390 gain_cnaBRCA12_(TERT) 262 VX-11e ERK 9 40 1.63315443905142 NA 3.6806582818634 3.79844651871995 -0.117788236856543 1.39711391915489 1.32763057851694 0.0879205624389404 0.0843082552121395 0.0887206416924509 0.81267604099446 NA NA NA 0.821695474377418 99.727107917785 a9391 gain_cnaBRCA8_(CHD4,WNK1) 157 JNK-9L JNK 3 44 1.63315443905142 NA 0.197404997585258 0.0461924319333389 0.151212565651919 0.0627953803777341 1.08762977515154 0.1422149189615 2.40802053817219 0.139029446514417 0.812705225284695 NA NA NA 0.372665964889513 99.727107917785 a9392 POLR2B_mut 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 46 3.68887945411394 NA 3.29947636243384 3.46989224212921 -0.17041587969537 1.83244767997545 1.16755093343023 0.141617670142639 0.0929990425143564 0.145960124578628 0.813176605555468 NA NA NA 0.88761951668559 99.727107917785 a9393 loss_cnaBRCA28_(GPS2) 1378 Bleomycin (50 uM) DNA damage 4 44 3.91202300542815 NA 4.02879998210511 3.79307376144933 0.235726220655786 1.80971625322212 1.90523117021835 0.124122066615582 0.130255900744708 0.123725784220069 0.813188124353505 NA NA NA 0.817296352947404 99.727107917785 a9394 NF1_mut 1039 SL 0101-1 RSK, AURKB, PIM3 4 39 2.30258509299405 NA 4.53885016733772 4.66010817370127 -0.121258006363552 0.941385959737003 0.974181799618979 0.12477418878942 0.1288079613992 0.124471640109658 0.813329851658438 NA NA NA 0.819797993844858 99.727107917785 a9395 loss_cnaBRCA38 1039 SL 0101-1 RSK, AURKB, PIM3 3 40 2.30258509299405 NA 4.77742863718339 4.63918333830375 0.138245298879641 0.111371413582232 0.996107423623268 0.142254056478931 1.24129966957424 0.138785532163573 0.81334324629242 NA NA NA 0.422007116694657 99.727107917785 a9396 TP53_mut 309 Y-39983 ROCK 38 11 2.99573227355399 NA 4.91510262780271 5.00365141625918 -0.0885487884564649 1.0727374159124 1.15499072774045 0.0811809881092272 0.0825447002621337 0.076666233182405 0.813604233873798 NA NA NA 0.823069979213907 99.727107917785 a9397 gain_cnaBRCA13_(FGFR1,WHSC1L1) 106 XMD8-85 MAP2K5 (ERK5) 3 10 2.07944154167984 NA 3.07042349788749 3.27014496603237 -0.199721468144874 1.35374996887887 1.23356069537177 0.158979876791863 0.147532020488448 0.161906478452349 0.813604490619 NA NA NA 0.833501920022375 99.727107917785 a9398 loss_cnaBRCA20 273 CUDC-101 HDAC, EGFR 3 46 1.63315443905142 NA -0.235958494114588 -0.0129978602412357 -0.222960633873352 0.441499044844356 1.61138408712337 0.141171980191074 0.505008190792244 0.138365915150236 0.813753405575423 NA NA NA 0.543340250376394 99.727107917785 a9399 loss_cnaBRCA24 1072 BMS-708163 g-secretase 3 43 1.6094379124341 NA 3.55703231323479 3.69312540535436 -0.136093092119566 1.32852772974675 0.94087299156646 0.141485243672308 0.102439030117578 0.144645550822948 0.813807792947457 NA NA NA 0.876651814979516 99.727107917785 a9400 gain_cnaBRCA19 255 CP724714 ERBB2 4 44 2.32630161961136 NA 3.61254592914992 3.82035293577138 -0.207807006621459 2.11992009713735 1.64515968938132 0.123678714816335 0.0980258675324947 0.126314185767344 0.813842735263968 NA NA NA 0.859642397459051 99.727107917785 a9401 gain_cnaBRCA19 1033 Vismodegib SMO 4 41 2.30258509299405 NA 4.84880260560212 4.75108890764088 0.0977136979612423 0.49360747075033 0.805990572878174 0.123966908582401 0.197958304424988 0.12123429386067 0.814045806387298 NA NA NA 0.73945656845777 99.727107917785 a9402 gain_cnaBRCA62 51 Dasatinib ABL, SRC, KIT, PDGFR 4 8 0.246860077931526 NA 1.84988939178842 2.0230961133119 -0.173206721523482 1.13791049146219 1.18547611534662 0.14786183583229 0.152214715325206 0.146107305985527 0.814079691002516 NA NA NA 0.814119066779123 99.727107917785 a9403 loss_cnaBRCA34 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 5 43 0.246860077931526 2.32630161961136 -0.431623355986765 -0.245571466174611 -0.186051889812154 1.73259980931352 1.65831455656677 0.111749204136796 0.107383071850776 0.112193364687903 0.814089689304183 NA NA NA 0.828672752340927 99.727107917785 a9404 loss_cnaBRCA20 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 3 42 -0.669430653942629 NA -3.16301546169335 -3.50927549226212 0.346260030568767 1.70767679975302 2.4796821873562 0.141378124219027 0.202766724135882 0.13963887482611 0.814113092117114 NA NA NA 0.767526715572028 99.727107917785 a9405 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 283 GSK2126458 PI3K, MTOR 9 39 -2.05572501506252 0.0237165266173161 -2.93845424233284 -3.08233567208575 0.143881429752916 1.27846996867342 1.71271497600542 0.0874421560082763 0.112541892479658 0.0840078073518639 0.814127170927218 NA NA NA 0.780248178404745 99.727107917785 a9406 gain_cnaBRCA12_(TERT) 172 Embelin XIAP 9 39 3.46573590279973 NA 3.06224202237595 2.97709760073983 0.0851444216361128 0.910473387738328 0.987514959502253 0.0873675754133974 0.0935166505499044 0.0862208929766785 0.814282714361643 NA NA NA 0.807480101101963 99.727107917785 a9407 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 254 AC220 FLT3 6 42 0.0237165266173161 NA 2.14354840801504 2.23522096708527 -0.0916725590702323 0.72489793039405 0.907445889830296 0.103069988329153 0.12646271319936 0.101022617544035 0.814354591661816 NA NA NA 0.78709363409938 99.727107917785 a9408 gain_cnaBRCA8_(CHD4,WNK1) 346 THZ-2-102-1 CDK7 4 44 0.916290731874155 2.99573227355399 -1.62483127185872 -1.30882367202608 -0.316007599832646 2.99009421651576 2.52978378643134 0.123328417314068 0.105684830293032 0.124914864870102 0.814360046105131 NA NA NA 0.849373957554268 99.727107917785 a9409 ASH1L_mut 1219 PFI-1 BRD2, BRD3, BRD4 3 44 2.30258509299405 NA 3.30508334609315 3.16343999764224 0.141643348450908 1.20674956853499 0.994662237956602 0.14093316437369 0.117375926326508 0.142403464257269 0.814361311589364 NA NA NA 0.859406939207807 99.727107917785 a9410 gain_cnaBRCA8_(CHD4,WNK1) 140 Vinorelbine Microtubules 3 44 -2.74887219562247 NA -3.38115674569951 -3.61472577732171 0.233569031622201 2.2852616555527 1.62293511573892 0.140873990667973 0.10220669088578 0.143917664580113 0.814437787534796 NA NA NA 0.87690775828996 99.727107917785 a9411 gain_cnaBRCA9_(KRAS) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 4 44 2.07944154167984 NA 3.08220556096381 3.22631234989376 -0.144106788929948 1.78068019426517 1.11405214258091 0.123255438428356 0.0809279450594535 0.129353720011792 0.81446783008464 NA NA NA 0.883095821451992 99.727107917785 a9412 gain_cnaBRCA58_(CCND1) 1170 CCT018159 HSP90 6 37 2.30258509299405 NA 3.23545196334243 3.36024080705358 -0.124788843711151 0.688104301899315 1.25530351541886 0.103941625305486 0.18135164010268 0.0994092999648079 0.814473684281323 NA NA NA 0.72688941768965 99.727107917785 a9413 gain_cnaBRCA62 6 PHA-665752 MET 5 9 0.693147180559945 NA 2.93153198856923 2.8270934055085 0.104438583060726 0.787026514496617 0.778205997987974 0.133697261140547 0.132700209125133 0.134204289520703 0.814609649942926 NA NA NA 0.81700355900029 99.727107917785 a9414 gain_cnaBRCA16 346 THZ-2-102-1 CDK7 16 32 0.916290731874155 2.99573227355399 -1.21183988052404 -1.39681651775618 0.184976637232134 2.91885060338255 2.37065050056446 0.0721907678408777 0.0633731089277989 0.0780277975129993 0.814654596814939 NA NA NA 0.827781979989516 99.727107917785 a9415 PTEN_mut 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 9 39 2.32630161961136 NA 4.90885917190808 4.96994376460851 -0.0610845927004284 0.54178644369491 0.729773800864894 0.0871749635657398 0.112746624451952 0.0837034607545979 0.814684455817428 NA NA NA 0.780181014725837 99.727107917785 a9416 TP53_mut 1072 BMS-708163 g-secretase 36 10 1.6094379124341 NA 3.66662614076351 3.74769483024555 -0.0810686894820356 0.955799522137572 0.985240863000551 0.0842801923382566 0.0848176710747163 0.0822831172827534 0.814701255182977 NA NA NA 0.820124773059594 99.727107917785 a9417 loss_cnaBRCA29_(MAP2K4) 1494 SN-38 TOP1 7 41 -2.99573227355399 NA -3.44326561822803 -3.27997534509112 -0.163290273136903 1.06057405443173 1.77095697077734 0.0963213960479019 0.153964046597761 0.0922045401618247 0.814844170507584 NA NA NA 0.742905809774983 99.727107917785 a9418 ARID1A_mut 273 CUDC-101 HDAC, EGFR 5 44 1.63315443905142 NA -0.184267698370291 -0.00873724003611715 -0.175530458334173 1.70927604095048 1.56673378013182 0.111139825847362 0.102692867698869 0.11203591864816 0.814847130022765 NA NA NA 0.835372799668419 99.727107917785 a9419 loss_cnaBRCA29_(MAP2K4) 223 ZSTK474 PI3K 7 42 1.63315443905142 2.32630161961136 1.03242081800655 0.892324151886863 0.140096666119683 1.121886758501 1.50040580382893 0.0961167323508886 0.124875942298198 0.0933725167965667 0.81489246909408 NA NA NA 0.777764267581823 99.727107917785 a9420 gain_cnaBRCA31 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 13 29 1.38629436111989 0.693147180559945 3.49058780382795 3.40780723192849 0.0827805718994581 0.880862959617629 1.11813597170257 0.0786450119995902 0.0939766748001211 0.0740344412436795 0.81492766082955 NA NA NA 0.798079131101986 99.727107917785 a9421 NF1_mut 283 GSK2126458 PI3K, MTOR 4 44 -2.05572501506252 0.0237165266173161 -2.8700350042285 -3.07220544035059 0.202170436122089 2.11779048180437 1.607332092885 0.12286582997494 0.0954629071473767 0.125780127838556 0.815043311954585 NA NA NA 0.863150229460491 99.727107917785 a9422 loss_cnaBRCA7_(FAS,PTEN) 1059 AZD8055 MTORC1/2 4 39 0.693147180559945 NA 0.0167557677178165 0.142089704514043 -0.125333936796226 1.48036286994171 0.969469487072187 0.123408254995954 0.0846643342258114 0.12928095052763 0.815334930644676 NA NA NA 0.878101039128389 99.727107917785 a9423 loss_cnaBRCA29_(MAP2K4) 271 VNLG/124 HDAC, RAR 7 42 1.63315443905142 NA 4.08416198998424 4.16265312490509 -0.0784911349208475 0.956738410724595 0.796561426880762 0.0958663028443897 0.0820403299804818 0.0985374539515543 0.815365770503305 NA NA NA 0.842674889848144 99.727107917785 a9424 BRCA1_mut 1031 Elesclomol HSP70 4 40 -1.6094379124341 NA -3.17909566302499 -2.95742741132532 -0.221668251699676 3.0976259427203 1.65738851393215 0.123223126952469 0.0715606906058547 0.133745497713006 0.815368251053535 NA NA NA 0.896263373235027 99.727107917785 a9425 gain_cnaBRCA13_(FGFR1,WHSC1L1) 89 Parthenolide NFKB1 4 10 1.6094379124341 NA 3.10409915460218 3.30817223378967 -0.20407307918749 1.5734469541351 1.39988986142989 0.141204136470211 0.129698099228052 0.145777953544891 0.815382188812952 NA NA NA 0.830046267365177 99.727107917785 a9426 loss_cnaBRCA36_(FAT1,IRF2) 1194 SB-505124 TGFR1 (ALK5) 9 38 2.30258509299405 NA 4.45408301244717 4.37358447585506 0.0804985365921045 0.696100031132202 0.96695414924306 0.0870612586063002 0.115642196511864 0.0832495901228816 0.815391170915933 NA NA NA 0.777429364797006 99.727107917785 a9427 gain_cnaBRCA64_(SDHC) 1026 17-AAG HSP90 7 36 0 NA -1.04242862326548 -0.86777459991259 -0.174654023352888 1.11114420134788 1.89354048855063 0.0970080367677546 0.157183939889191 0.0922367514235588 0.815501143768977 NA NA NA 0.744490002734784 99.727107917785 a9428 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 265 Tubastatin A HDAC6 9 40 2.99573227355399 NA 4.76539808565857 4.67519081003993 0.0902072756186385 0.983773799216687 1.05368425390125 0.0865616570017025 0.09169513936076 0.0856112970129785 0.815517092013966 NA NA NA 0.810246309324374 99.727107917785 a9429 gain_cnaBRCA13_(FGFR1,WHSC1L1) 261 TL-1-85 MAP3K7 (TAK1) 11 38 2.32630161961136 NA 3.94880666573929 4.04680640810685 -0.0979997423675609 1.38840978343381 1.17062664649791 0.0803129712799816 0.0705841629300451 0.0837156258664883 0.815560017620834 NA NA NA 0.834171975448798 99.727107917785 a9430 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1241 CHIR-99021 GSK3B 6 40 2.30258509299405 NA 4.14351770320741 4.24468250087887 -0.101164797671468 1.00308749390676 0.982429849950899 0.102726326938639 0.100853413372206 0.102974067488406 0.815573990077977 NA NA NA 0.824404107162096 99.727107917785 a9431 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 312 AV-951 VEGFR 5 43 -2.05572501506252 NA 0.568121092630344 0.639735703740863 -0.0716146111105193 0.597956752631411 0.650509001758525 0.110839838130783 0.119765536212054 0.110090115458699 0.815574308826094 NA NA NA 0.811429403064121 99.727107917785 a9432 loss_cnaBRCA33 1032 Afatinib ERBB2, EGFR 5 40 -0.693147180559945 NA 0.10789939810174 0.313293235931815 -0.205393837830075 1.54287082544402 1.87377387807349 0.111294604493874 0.133124455037229 0.109615060938543 0.815609896196545 NA NA NA 0.794268834479502 99.727107917785 a9433 loss_cnaBRCA60 1371 PLX4720 (rescreen) BRAF 3 44 2.30258509299405 NA 4.83333857466713 4.69854339621761 0.134795178449515 0.367319095042777 0.982187583747356 0.139940666837425 0.366970245404251 0.137239750002977 0.815644254183192 NA NA NA 0.627528762280249 99.727107917785 a9434 PTEN_mut 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 9 40 3.68887945411394 NA 3.37449210683906 3.47857608159234 -0.10408397475328 1.33885988279696 1.1736469961536 0.0864936533440199 0.0777407524795215 0.0886842254054197 0.815659332773157 NA NA NA 0.833458948717789 99.727107917785 a9435 POLR2B_mut 304 SB52334 ALK5 3 46 2.99573227355399 NA 4.46996537312857 4.29093042443107 0.179034948697502 0.557539630806943 1.30497930996068 0.139644017253546 0.321116094363336 0.137193706697845 0.815731643940114 NA NA NA 0.66014397275644 99.727107917785 a9436 loss_cnaBRCA23 1067 CCT007093 PPM1D 3 43 1.88706964903238 NA 4.21556208731957 4.0765716287844 0.138990458535166 1.0591928968666 0.989574799147822 0.139992078561678 0.131222989642718 0.140454727277674 0.815736064429556 NA NA NA 0.84378265093417 99.727107917785 a9437 gain_cnaBRCA47_(EGFR) 1058 GDC0941 PI3K (class 1) 6 37 1.38629436111989 0.693147180559945 1.22190089245738 1.36612716582999 -0.144226273372608 1.02605896796038 1.44142899710348 0.103210430468736 0.14056333785504 0.100057840977549 0.815754408098803 NA NA NA 0.771546398067415 99.727107917785 a9438 BRCA2_mut 346 THZ-2-102-1 CDK7 6 42 0.916290731874155 2.99573227355399 -1.10588228509274 -1.36791126061966 0.262028975526921 2.47847959188492 2.57239111816804 0.102261192925476 0.105721659514511 0.101862027774971 0.815784236891536 NA NA NA 0.816770441757389 99.727107917785 a9439 NF1_mut 1529 MLN4924 NEDD8-activating enzyme 5 32 0 NA 0.20186028001523 0.395364489901995 -0.193504209886766 1.3311476931777 1.75838791065591 0.112833341642004 0.145366446472092 0.110046371858065 0.815857735369463 NA NA NA 0.782325632352001 99.727107917785 a9440 loss_cnaBRCA36_(FAT1,IRF2) 221 TAK-715 p38a 9 40 2.99573227355399 2.32630161961136 4.41070011794236 4.4982295479851 -0.0875294300427383 1.04211638339779 1.00755466862923 0.0863617544856902 0.0839919911414797 0.0868731323153132 0.815935238653802 NA NA NA 0.822822608562647 99.727107917785 a9441 gain_cnaBRCA15 226 GSK1070916 AURKB 22 27 0.940007258491471 2.32630161961136 2.47660152087259 2.34474830711319 0.131853213759401 1.9165983553571 1.99645158793367 0.0672317654076672 0.0687954330080986 0.0660437821564557 0.815937305758204 NA NA NA 0.815196785002895 99.727107917785 a9442 MLL3_mut 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 39 1.38629436111989 0.693147180559945 3.57063050087486 3.42287588905295 0.147754611821906 1.54230275760937 1.02032913706637 0.140371972862292 0.0958013017177846 0.144810734550547 0.815957060169318 NA NA NA 0.884497553216292 99.727107917785 a9443 loss_cnaBRCA38 157 JNK-9L JNK 4 43 1.63315443905142 NA -0.063124720635816 0.0669111832643244 -0.13003590390014 0.657730604700534 1.08648352456294 0.122295530419085 0.197703897265577 0.119685113451168 0.81608372417822 NA NA NA 0.739294201616939 99.727107917785 a9444 gain_cnaBRCA15 1019 Bosutinib SRC, ABL, TEC 21 24 0.693147180559945 NA 2.69764651625683 2.63193155573149 0.0657149605253382 0.936296910100512 0.945215022130111 0.0698294829457045 0.0701860273343032 0.0695238215504074 0.816331458516355 NA NA NA 0.816232773140893 99.727107917785 a9445 ASH1L_mut 193 GW-2580 CSF1R (cFMS) 3 45 2.99573227355399 NA 5.36533130724773 5.46992603821323 -0.104594730965496 0.529390883125109 0.759520262880791 0.139277194027582 0.197575618129369 0.137711574104392 0.816351333567024 NA NA NA 0.772444237919816 99.727107917785 a9446 loss_cnaBRCA34 1019 Bosutinib SRC, ABL, TEC 5 40 0.693147180559945 NA 2.56988369116504 2.6741878930781 -0.104304201913064 1.28243170485199 0.898766259931747 0.110834840266656 0.0813331435260343 0.116052645235019 0.816357523702215 NA NA NA 0.867536978246135 99.727107917785 a9447 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1003 Camptothecin TOP1 17 28 -2.30258509299405 NA -2.60076309146788 -2.48588187237032 -0.114881219097565 1.37228860520476 1.72128321616757 0.0717854889831141 0.083715057213073 0.0667416134768035 0.816503213588108 NA NA NA 0.80629776803898 99.727107917785 a9448 loss_cnaBRCA7_(FAS,PTEN) 1013 Nilotinib ABL 4 36 0.693147180559945 NA 3.30989173361991 3.19102023227063 0.118871501349277 0.375420324858758 1.00029778713087 0.123083604847415 0.316635763910755 0.118836113483998 0.816599737137141 NA NA NA 0.647003745336953 99.727107917785 a9449 gain_cnaBRCA16 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 16 32 2.07944154167984 NA 3.26992667679018 3.18649183782931 0.0834348389608666 1.35465649612628 1.06794596762132 0.0713612673727799 0.0615911407795652 0.078126460973212 0.816744980012286 NA NA NA 0.831393203738998 99.727107917785 a9450 gain_cnaBRCA47_(EGFR) 235 QL-XII-47 BTK, BMX 7 42 2.32630161961136 NA 1.83153307036043 1.68749876556399 0.144034304796437 1.04294255314801 1.57165019065721 0.0951055425208268 0.138103776053326 0.0916452691907268 0.816804001901955 NA NA NA 0.761372845880987 99.727107917785 a9451 loss_cnaBRCA33 62 BMS-536924 IGF1R 4 8 1.63315443905142 NA 3.0595560445751 3.21702892429207 -0.157472879716967 1.29708366691425 0.974190331849755 0.14564221068685 0.121405337013914 0.161644880439291 0.816812981572415 NA NA NA 0.839067029072149 99.727107917785 a9452 loss_cnaBRCA20 1026 17-AAG HSP90 3 40 0 NA -0.662508196150905 -0.913734034281472 0.251225838130567 1.41632343133174 1.81793687216883 0.139536916023798 0.17737886175783 0.138192828352093 0.81684225754542 NA NA NA 0.794080571546257 99.727107917785 a9453 gain_cnaBRCA15 1010 Gefitinib EGFR 21 24 -0.693147180559945 NA 1.36096902731776 1.43396050361951 -0.0729914763017465 1.03003876097306 1.0660773459699 0.0695508535436905 0.0708628442611154 0.0684673364251447 0.817050861815942 NA NA NA 0.81664082785132 99.727107917785 a9454 loss_cnaBRCA28_(GPS2) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 4 42 0 NA 0.883827285498065 0.63125208446176 0.252575201036305 1.56543557259076 2.10711975804084 0.121741507967681 0.161344999090764 0.119867511123879 0.817107331576464 NA NA NA 0.780142289814655 99.727107917785 a9455 CDH1_mut 329 QL-XI-92 DDR1 4 44 2.32630161961136 NA 4.14722048336298 4.26298188135899 -0.115761397996006 0.499700206730296 0.977101714863041 0.121434502631289 0.231661697227366 0.118474255274674 0.817158376021986 NA NA NA 0.70509644052699 99.727107917785 a9456 loss_cnaBRCA33 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 5 38 0.693147180559945 NA 3.00254325043729 2.89603388339482 0.106509367042473 0.648809616893634 0.99133311602529 0.110568021049445 0.16416120271524 0.107440541752018 0.817368687133614 NA NA NA 0.757852998497457 99.727107917785 a9457 gain_cnaBRCA27_(CLTC,PPM1D) 235 QL-XII-47 BTK, BMX 9 40 2.32630161961136 NA 1.60223019785618 1.73189019663762 -0.129659998781448 1.84161166029156 1.43820155494123 0.0856138376233786 0.0704057221058863 0.0901542612966695 0.817500174761323 NA NA NA 0.846846938030504 99.727107917785 a9458 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 229 LY317615 PRKCB (PKCbeta) 6 43 2.99573227355399 2.32630161961136 3.50276491228398 3.33846467568773 0.164300236596247 0.504923873574627 1.71009164797507 0.101111613994145 0.325396055118324 0.0960768604365714 0.817534959920625 NA NA NA 0.625287124575635 99.727107917785 a9459 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1262 UNC1215 LMBL3 6 40 0 NA 2.7047017292171 2.76544309694002 -0.060741367722922 0.496945304200799 0.610121351618281 0.101516557561244 0.122229483223728 0.0995562072394486 0.817706178467043 NA NA NA 0.794182893752633 99.727107917785 a9460 loss_cnaBRCA34 223 ZSTK474 PI3K 5 44 1.63315443905142 2.32630161961136 1.05542360965706 0.896078228568381 0.159345381088677 0.905870575961207 1.49862771556436 0.109320722897125 0.17590303219596 0.106327528467382 0.817822281942253 NA NA NA 0.74156066822723 99.727107917785 a9461 loss_cnaBRCA36_(FAT1,IRF2) 140 Vinorelbine Microtubules 9 38 -2.74887219562247 NA -3.71494384495031 -3.57255025880793 -0.142393586142388 1.81856014410007 1.62124177928087 0.0858807878193878 0.0783001797352446 0.0878299510672302 0.817848575824485 NA NA NA 0.833253987743433 99.727107917785 a9462 gain_cnaBRCA27_(CLTC,PPM1D) 190 Bleomycin DNA damage 9 39 4.15888308335967 NA 2.27066360818085 2.0340304366714 0.236633171509451 3.02308953695785 2.70473559543454 0.0856516896625135 0.0782752772012094 0.0874884672309102 0.817863399477408 NA NA NA 0.833084396367478 99.727107917785 a9463 ASH1L_mut 1049 PD-173074 FGFR1, FGFR3 3 40 0.693147180559945 NA 3.08637600985253 2.92661808840272 0.159757921449816 0.653447296415763 1.17157084179643 0.138712822282279 0.244484784505357 0.136362152206563 0.817904240550036 NA NA NA 0.728630369411105 99.727107917785 a9464 CDH1_mut 140 Vinorelbine Microtubules 4 43 -2.74887219562247 NA -3.78345277850837 -3.5827347284935 -0.20071805001487 1.40510273346427 1.67464404365318 0.121057538474009 0.142849376941999 0.119857142642093 0.817911576626276 NA NA NA 0.802110096009476 99.727107917785 a9465 gain_cnaBRCA47_(EGFR) 150 Bicalutamide ANDR (androgen receptor) 7 41 0.0237165266173161 NA 2.81335193967816 2.75392068556055 0.0594312541176043 0.492374320701155 0.645688982073698 0.0946631500397298 0.120703399058205 0.0920431597372694 0.817973557635982 NA NA NA 0.784652029066352 99.727107917785 a9466 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1033 Vismodegib SMO 17 28 2.30258509299405 NA 4.72485607670157 4.78097508327707 -0.0561190065754973 0.856683072415401 0.744728808418497 0.0711947934948953 0.0655073134773994 0.0753549559801122 0.817985634043967 NA NA NA 0.824554360662982 99.727107917785 a9467 MACF1_mut 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 39 -1.38629436111989 0.693147180559945 -0.0822094654948809 -0.319163145991457 0.236953680496576 1.08928325306724 1.73598476663812 0.138612361402916 0.217531739177441 0.136495253328436 0.818221988408906 NA NA NA 0.754219532158422 99.727107917785 a9468 MACF1_mut 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 40 1.6094379124341 NA 2.35934425668641 2.58294118325894 -0.223596926572528 0.570354733369681 1.65185643304296 0.138366069280231 0.392031333292366 0.13536099269876 0.818351193679706 NA NA NA 0.61665833928235 99.727107917785 a9469 PIK3CA_mut 329 QL-XI-92 DDR1 16 32 2.32630161961136 NA 4.29825401772706 4.23087563842545 0.0673783793016085 1.14600967075077 0.844393904024617 0.0706797822946889 0.0587939011522196 0.0797949617831966 0.818463365804005 NA NA NA 0.836590899446263 99.727107917785 a9470 gain_cnaBRCA47_(EGFR) 196 Phenformin AAPK1 (AMPK) agonist 7 41 8.29404964010203 NA 7.34893325907312 7.1769291517295 0.172004107343619 1.6026514105024 1.85522493045432 0.0942868104944031 0.107324715915421 0.092713344091111 0.818684192522099 NA NA NA 0.803593583382469 99.727107917785 a9471 BRCA1_mut 329 QL-XI-92 DDR1 4 44 2.32630161961136 NA 4.35848150985961 4.24377633349566 0.114705176363955 0.563467654802426 0.974688975803275 0.120325234305538 0.203570116911459 0.117683875791683 0.818798482625083 NA NA NA 0.733357795897087 99.727107917785 a9472 gain_cnaBRCA12_(TERT) 178 BAY 61-3606 SYK 9 39 2.07944154167984 NA 2.98377919071232 3.12159289034067 -0.137813699628349 1.2660941135393 1.68248870069418 0.08518643111212 0.108849490851117 0.081910624167335 0.818834974449944 NA NA NA 0.786806831647428 99.727107917785 a9473 loss_cnaBRCA17 1007 Docetaxel Microtubules 8 37 -4.38202663467388 NA -4.70214348367719 -4.56244423322444 -0.139699250452748 1.80800472190674 1.50083067399856 0.0898401157420856 0.0772670827460115 0.0930812868320158 0.818862376197964 NA NA NA 0.842882704636745 99.727107917785 a9474 gain_cnaBRCA48 1199 Tamoxifen ER 5 42 1.6094379124341 NA 3.96264634965678 3.85804211189293 0.104604237763851 1.14985982048004 0.939350120786373 0.108970321816256 0.0909712957186211 0.111358092631405 0.81887169822803 NA NA NA 0.853026903886733 99.727107917785 a9475 gain_cnaBRCA15 222 BX-912 PDPK1 (PDK1) 22 27 2.32630161961136 NA 3.82830865811914 3.92898028648147 -0.100671628362333 1.51410583971656 1.52856046834829 0.0661391320819909 0.0664891619341342 0.0658604160233946 0.818874626453066 NA NA NA 0.81873837728679 99.727107917785 a9476 gain_cnaBRCA12_(TERT) 206 Ruxolitinib JAK1, JAK2, TYK2 9 40 1.65632149833295 0.0237165266173161 4.41586985576833 4.35999833655749 0.0558715192108394 0.402858765852962 0.69880720065224 0.0849236815345272 0.138687609521278 0.0799526953338362 0.818944919175178 NA NA NA 0.751236095184127 99.727107917785 a9477 loss_cnaBRCA28_(GPS2) 228 KIN001-102 AKT1 4 45 2.32630161961136 NA 2.09990106880309 1.92981937617363 0.170081692629461 0.895283844922923 1.44510014084951 0.120080553538345 0.189975161055323 0.117695437030043 0.818974039815228 NA NA NA 0.747366827096763 99.727107917785 a9478 TP53_mut 170 Shikonin unknown 37 10 2.77258872223978 NA 0.0244713245247159 -0.0735862673212057 0.0980575918459216 1.0894409221543 1.54741727429422 0.0820456391564594 0.0900072595510907 0.0633685518927956 0.818978780336017 NA NA NA 0.854009034022492 99.727107917785 a9479 loss_cnaBRCA57 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 5 42 2.99573227355399 NA 3.70785380971271 3.86430623487424 -0.156452425161531 1.52355647010237 1.42917418209724 0.108812654185792 0.102688957207486 0.109470508998382 0.819129079915356 NA NA NA 0.835915995918803 99.727107917785 a9480 loss_cnaBRCA23 202 GSK-1904529A IGF1R 3 45 0.0237165266173161 NA 2.29737938156618 2.18249409445841 0.114885287107767 0.399960125195901 0.853292829852677 0.136981243639515 0.287241852050868 0.134637586404661 0.819324297314189 NA NA NA 0.689326368058273 99.727107917785 a9481 loss_cnaBRCA23 231 FMK RSK 3 46 2.99573227355399 2.32630161961136 5.51249549455528 5.59423410189873 -0.0817386073434507 0.437994923426406 0.603590967676104 0.136805590976116 0.18661998797615 0.135420527676473 0.819409736280643 NA NA NA 0.783802102222663 99.727107917785 a9482 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1050 ZM-447439 AURKB 7 32 1.38629436111989 0.693147180559945 2.78348765318158 2.91076955026665 -0.127281897085069 1.25125046694755 1.34295092986408 0.0958079618905897 0.101723755912416 0.0947777720351641 0.819658429917125 NA NA NA 0.815142447855411 99.727107917785 a9483 MLL3_mut 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 3 40 1.6094379124341 NA 3.13972884433636 2.93136992890579 0.208358915430567 1.14547841162974 1.53382379331184 0.137332293647907 0.181896850534375 0.1358427978097 0.819684059022868 NA NA NA 0.789624719455895 99.727107917785 a9484 CDH1_mut 1024 CEP-701 FLT3, JAK2, NTRK1, RET 4 41 0.693147180559945 NA 0.783736330628574 0.610137955694938 0.173598374933636 1.10375030641388 1.46897332263176 0.120013688544248 0.157280477228281 0.118176669554913 0.819868683842665 NA NA NA 0.785507347838729 99.727107917785 a9485 MACF1_mut 1259 BMN-673 PARP1 3 43 2.30258509299405 NA 3.50577294415648 3.29156816349707 0.214204780659413 1.85690094219583 1.55330576755276 0.136577006986308 0.115356062238899 0.137902520633071 0.820150606184083 NA NA NA 0.861872795109872 99.727107917785 a9486 NF1_mut 281 CH5424802 ALK 4 44 1.63315443905142 NA 3.45791561333315 3.58590544538496 -0.127989832051809 1.30049642506074 1.0546999491073 0.119343544656182 0.0984161352429947 0.121351889852787 0.820250641683595 NA NA NA 0.859324583634769 99.727107917785 a9487 POLR2B_mut 1502 Bicalutamide ANDR (androgen receptor) 3 42 2.30258509299405 NA 4.48341237220428 4.56365247300214 -0.0802401007978615 0.838460775023217 0.572860946010067 0.136490314634694 0.0956992899228228 0.140069071485371 0.820424202332996 NA NA NA 0.884608979003993 99.727107917785 a9488 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1072 BMS-708163 g-secretase 6 40 1.6094379124341 NA 3.76784431876567 3.6717105864337 0.0961337323319706 1.52775269987108 0.862966208964176 0.0999380827062369 0.062924930415821 0.111399184966188 0.820490297729025 NA NA NA 0.885692214311517 99.727107917785 a9489 PIK3CA_mut 1016 Temsirolimus MTOR 16 28 -1.6094379124341 NA -1.81961231501187 -1.71170018431724 -0.107912130694623 1.53649590898809 1.49505874544025 0.0714655421449626 0.0702326182994476 0.0721791909674067 0.82072240676249 NA NA NA 0.822467145170796 99.727107917785 a9490 gain_cnaBRCA58_(CCND1) 1194 SB-505124 TGFR1 (ALK5) 9 38 2.30258509299405 NA 4.45215143579085 4.37404195453682 0.0781094812540326 0.624809848752738 0.977463797783661 0.0844744060814754 0.125013204273199 0.0799103572236036 0.820778678198329 NA NA NA 0.768704980366913 99.727107917785 a9491 BRCA1_mut 1175 AG-014699 PARP1, PARP2 4 39 1.6094379124341 NA 3.9738003860119 3.8500599062495 0.123740479762402 0.439431698963313 1.06747795559272 0.11960991982081 0.281592065511717 0.115918534068177 0.820917131050619 NA NA NA 0.66919938561545 99.727107917785 a9492 gain_cnaBRCA13_(FGFR1,WHSC1L1) 206 Ruxolitinib JAK1, JAK2, TYK2 11 38 1.65632149833295 0.0237165266173161 4.33050034836925 4.38176995610928 -0.0512696077400268 1.09102135891434 0.477621503857652 0.0779278818946673 0.0469923043404432 0.107343591789592 0.820940088246656 NA NA NA 0.882134590024555 99.727107917785 a9493 loss_cnaBRCA29_(MAP2K4) 1018 ABT-888 PARP1, PARP2 6 39 1.6094379124341 NA 4.46096475671545 4.39417025899216 0.0667944977232944 0.634247526808942 0.673852075204245 0.0997875120541218 0.10531298097346 0.0991233835750212 0.821074180813709 NA NA NA 0.818747443220573 99.727107917785 a9494 TP53_mut 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 36 10 0 NA 0.616534176137319 0.785266634844269 -0.16873245870695 1.80589123627015 2.89168404724775 0.08132703511342 0.0934344523734698 0.0583509318272673 0.821078321421732 NA NA NA 0.864044408208532 99.727107917785 a9495 gain_cnaBRCA62 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 7 35 -1.38629436111989 0.693147180559945 -0.168263219094431 -0.329032815899727 0.160769596805296 2.7342805058815 1.45561197098804 0.0940441868989885 0.0587977701846891 0.110448113927072 0.821473128033294 NA NA NA 0.884169945481797 99.727107917785 a9496 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1017 Olaparib PARP1, PARP2 7 38 1.6094379124341 NA 4.00343912306423 4.08711422474608 -0.0836751016818447 0.785605181478574 0.912771997143971 0.0933757388705386 0.106510373982464 0.0916714162393904 0.821482249342473 NA NA NA 0.806406520917872 99.727107917785 a9497 gain_cnaBRCA15 221 TAK-715 p38a 22 27 2.99573227355399 2.32630161961136 4.44577894120355 4.51179060275582 -0.0660116615522606 1.06242643765756 0.972294225891376 0.0651287048559701 0.0621329244195047 0.0678926808309929 0.82159329103723 NA NA NA 0.823287519647345 99.727107917785 a9498 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 51 Dasatinib ABL, SRC, KIT, PDGFR 3 9 0.246860077931526 NA 2.10091567213344 1.92017549524984 0.180740176883608 1.91237161559455 0.895416561411125 0.154256405565308 0.0945110120908255 0.201850384137157 0.821681783578209 NA NA NA 0.887244856627081 99.727107917785 a9499 gain_cnaBRCA27_(CLTC,PPM1D) 51 Dasatinib ABL, SRC, KIT, PDGFR 3 9 0.246860077931526 NA 2.10091567213344 1.92017549524984 0.180740176883608 1.91237161559455 0.895416561411125 0.154256405565308 0.0945110120908255 0.201850384137157 0.821681783578209 NA NA NA 0.887244856627081 99.727107917785 a9500 gain_cnaBRCA8_(CHD4,WNK1) 155 AP-24534 ABL 3 44 -0.669430653942629 NA 1.58994680919095 1.43550155307692 0.154445256114027 0.693156445873191 1.15957134277664 0.13513561402105 0.222814426719306 0.13319168076731 0.821862624810261 NA NA NA 0.748277505753278 99.727107917785 a9501 loss_cnaBRCA28_(GPS2) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 4 43 2.77258872223978 NA 4.89914873517001 5.02129708735823 -0.122148352188222 0.797629437886593 1.0468729981179 0.11834578476626 0.15313922278479 0.116679246105138 0.821918951372281 NA NA NA 0.790156932050354 99.727107917785 a9502 gain_cnaBRCA19 1069 EHT 1864 Rac GTPases 4 42 2.30258509299405 NA 3.46791590944081 3.57032700543144 -0.10241109599063 1.41218272447377 0.810668279273709 0.118384647985791 0.0725197201578801 0.126329225663525 0.822061788183828 NA NA NA 0.894981931287401 99.727107917785 a9503 loss_cnaBRCA28_(GPS2) 273 CUDC-101 HDAC, EGFR 4 45 1.63315443905142 NA -0.197704683155088 -0.0114435182404501 -0.186261164914638 0.946252535016623 1.6135883278332 0.117928661574818 0.196840862266611 0.115432890596549 0.822161594803255 NA NA NA 0.740725757245271 99.727107917785 a9504 ARID1A_mut 1052 RO-3306 CDK1 4 39 1.6094379124341 NA 3.65601815465531 3.51230466383164 0.143713490823667 0.340183720421615 1.25394097552949 0.118703220140812 0.422458460521132 0.114609454215325 0.822251060250173 NA NA NA 0.593061832095591 99.727107917785 a9505 gain_cnaBRCA15 293 MP470 PDGFR 22 26 2.99573227355399 NA 3.47200610984085 3.58199823100493 -0.109992121164081 1.88083980971529 1.49332839129246 0.0654188492898796 0.0584803238404078 0.0736556820358073 0.822334583040732 NA NA NA 0.825826672895886 99.727107917785 a9506 loss_cnaBRCA28_(GPS2) 303 PIK-93 PI4K, PI3K 4 45 2.99573227355399 NA 2.94642880283744 2.77775816827471 0.168670634562732 0.486969323594194 1.47424234613798 0.117810428693616 0.346368090124893 0.114411741736081 0.822336819204514 NA NA NA 0.61888968375435 99.727107917785 a9507 gain_cnaBRCA9_(KRAS) 221 TAK-715 p38a 4 45 2.99573227355399 2.32630161961136 4.5917685933266 4.47240908016842 0.119359513158177 1.11201319019111 1.00649905727109 0.117762391305383 0.107336418498474 0.118588797769762 0.822408014556637 NA NA NA 0.847447051545494 99.727107917785 a9508 PTEN_mut 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 9 38 2.32630161961136 NA 1.52138208695683 1.39219911034296 0.129182976613865 1.22458588254006 1.60437984470824 0.0836837051918401 0.105491152932379 0.0805189475796221 0.822427189585547 NA NA NA 0.793154505511917 99.727107917785 a9509 gain_cnaBRCA15 1054 PD-0332991 CDK4, CDK6 20 22 1.38629436111989 0.693147180559945 2.93687671401362 2.83383930586309 0.10303740815053 1.4208292579823 1.52675580246627 0.0697429586199103 0.0725192049443381 0.067487811727381 0.822555708299251 NA NA NA 0.821944556848228 99.727107917785 a9510 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1375 Temozolomide DNA akylating agent 18 28 3.40119738166216 NA 5.92929569915194 5.88137394444378 0.047921754708157 0.865338456515762 0.578202072462673 0.06815001572895 0.0553792037639368 0.082880634626661 0.822571929642134 NA NA NA 0.837494838176238 99.727107917785 a9511 NF1_mut 156 AZD6482 PI3Kbeta 4 43 1.63315443905142 NA 2.2120392611227 2.03854427086205 0.173494990260651 0.625047518882778 1.51482590489013 0.117836818324468 0.277570880644018 0.114531306667373 0.82267163076228 NA NA NA 0.668730133091254 99.727107917785 a9512 loss_cnaBRCA29_(MAP2K4) 1019 Bosutinib SRC, ABL, TEC 6 39 0.693147180559945 NA 2.58199593540717 2.67499893760272 -0.0930030021955557 0.65592068703281 0.972438476177548 0.0988216769701787 0.141790012167894 0.0956389576039103 0.822776075019047 NA NA NA 0.770949405535541 99.727107917785 a9513 loss_cnaBRCA34 1025 SB 216763 GSK3A, GSK3B 4 35 2.30258509299405 NA 4.80440181018265 4.89884813588002 -0.09444632569737 0.34350483731068 0.821555255608027 0.119010613944645 0.274949041290935 0.114960405952818 0.822842946063169 NA NA NA 0.680341918660304 99.727107917785 a9514 gain_cnaBRCA13_(FGFR1,WHSC1L1) 176 IPA-3 PAK1, PAK2, PAK3 10 37 3.46573590279973 NA 4.59280975168022 4.47090153063161 0.121908221048609 1.4002013068215 1.54885626505065 0.0801875537178287 0.087064781652964 0.0787085437166907 0.823007371975177 NA NA NA 0.814484090960044 99.727107917785 a9515 MACF1_mut 1050 ZM-447439 AURKB 3 36 1.38629436111989 0.693147180559945 3.0538962851643 2.87409306459197 0.179803220572331 0.319993071309838 1.36383421188158 0.135338298961181 0.56189723057545 0.13183656708851 0.823050129958266 NA NA NA 0.55161272745135 99.727107917785 a9516 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 228 KIN001-102 AKT1 6 43 2.32630161961136 NA 2.06548462253852 1.92671089459987 0.138773727938652 1.85514789577535 1.3547748938351 0.0979740729528416 0.0748046709670297 0.102433052583231 0.823098698117065 NA NA NA 0.86572877474595 99.727107917785 a9517 BRCA1_mut 156 AZD6482 PI3Kbeta 4 43 1.63315443905142 NA 1.89500012200248 2.06803628380346 -0.173036161800982 0.843142053789064 1.50726230400874 0.117524834115976 0.205227767993971 0.114801624999691 0.823133088598476 NA NA NA 0.733245049238455 99.727107917785 a9518 gain_cnaBRCA31 172 Embelin XIAP 16 32 3.46573590279973 NA 3.03769287381097 2.97074683278942 0.0669460410215468 1.18592258718838 0.853791840653153 0.0686899348523294 0.0564505995119501 0.0784102609487728 0.823485955587311 NA NA NA 0.842286601470312 99.727107917785 a9519 gain_cnaBRCA61_(NOTCH2) 203 BMS-345541 IKBKB 3 46 2.77258872223978 NA 3.40499796891213 3.54063654825428 -0.135638579342143 0.512850498876428 1.03180829812554 0.133615122240238 0.264479764842396 0.131457151089553 0.823548909737165 NA NA NA 0.709521003369678 99.727107917785 a9520 POLR2B_mut 286 KIN001-236 TIE2 3 46 2.32630161961136 NA 4.63690037284494 4.53379118343494 0.103109189409992 0.194519721730527 0.788220462987762 0.133507409280449 0.530070619537648 0.130812626989097 0.823688740948704 NA NA NA 0.540959513942171 99.727107917785 a9521 loss_cnaBRCA28_(GPS2) 211 TL-2-105 CRAF 4 45 2.32630161961136 1.63315443905142 4.02511382159445 3.8971039511797 0.128009870414753 0.536075561142321 1.12386429889538 0.116817915395408 0.238790722229489 0.113901536458246 0.823808111209102 NA NA NA 0.700145350119804 99.727107917785 a9522 loss_cnaBRCA17 45 Z-LLNle-CHO g-secretase 3 9 0.940007258491471 NA 0.794942173539554 1.03482681043207 -0.239884636892517 1.3649027818488 1.62376969456666 0.152268752931432 0.175752178164358 0.147733165420688 0.823935717975514 NA NA NA 0.813937581504472 99.727107917785 a9523 ARID1A_mut 200 LAQ824 HDAC 5 43 0.0237165266173161 NA -2.81900263536626 -2.66882377901507 -0.150178856351185 0.849842341566062 1.46349739089053 0.105707824359351 0.176713784434934 0.102616415503003 0.823965442195823 NA NA NA 0.74308929472968 99.727107917785 a9524 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1025 SB 216763 GSK3A, GSK3B 6 33 2.30258509299405 NA 4.8224070364151 4.90129847812244 -0.078891441707345 0.459849930833939 0.833769734843153 0.099409200502178 0.171559103128004 0.0946201791819487 0.82399803930009 NA NA NA 0.745236195962466 99.727107917785 a9525 gain_cnaBRCA12_(TERT) 1023 GW 441756 NTRK1 10 35 0.693147180559945 NA 2.4411135137613 2.33590772721855 0.105205786542754 1.05456559091615 1.37144601183481 0.0802195502348356 0.0997622029857398 0.0767115771491456 0.824033443321041 NA NA NA 0.798443861132796 99.727107917785 a9526 gain_cnaBRCA8_(CHD4,WNK1) 257 NPK76-II-72-1 PLK3 4 45 2.32630161961136 NA 3.64989661127052 3.46376595802827 0.186130653242248 1.62642857939124 1.59352314689167 0.116649252770184 0.114441332131482 0.116804486715687 0.824058198740175 NA NA NA 0.838205209504631 99.727107917785 a9527 MACF1_mut 1371 PLX4720 (rescreen) BRAF 3 44 2.30258509299405 NA 4.58690253836013 4.71534585323854 -0.128443314878418 0.251955610921364 0.983933192751993 0.133338837453141 0.509785491216966 0.1305406869334 0.82419088819774 NA NA NA 0.553772029870976 99.727107917785 a9528 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 176 IPA-3 PAK1, PAK2, PAK3 9 38 3.46573590279973 NA 4.59865247697759 4.47272583835194 0.125926638625648 1.53602170295439 1.51687966643635 0.0828301078236097 0.081982330316974 0.0830168940964784 0.824207741903333 NA NA NA 0.828299255392615 99.727107917785 a9529 PIK3CA_mut 1046 681640 WEE1, CHEK1 13 23 0.693147180559945 NA 2.68712390567358 2.60365239286424 0.0834715128093348 1.11661968574317 1.0540799694639 0.0775348452388087 0.0747537535609363 0.0791889754358843 0.824522095725651 NA NA NA 0.827898673265187 99.727107917785 a9530 gain_cnaBRCA58_(CCND1) 155 AP-24534 ABL 9 38 -0.669430653942629 NA 1.52173118454151 1.4272717921601 0.0944593923814114 0.828365169568791 1.20012986129382 0.082648078314184 0.114031101078987 0.0787076427542415 0.82458756576 NA NA NA 0.783164509364831 99.727107917785 a9531 loss_cnaBRCA28_(GPS2) 306 TG101348 JAK2 4 44 2.32630161961136 NA 3.08704301806085 3.23742037834769 -0.150377360286838 1.53134323556196 1.27382156865552 0.116374769611948 0.0981996438124821 0.11805213853111 0.82464604043015 NA NA NA 0.85977196805874 99.727107917785 a9532 loss_cnaBRCA23 1375 Temozolomide DNA akylating agent 3 43 3.40119738166216 NA 5.81263723358291 5.90622979833517 -0.0935925647522602 0.878296920155835 0.693750039014538 0.133097114881833 0.106561417448275 0.134908193857844 0.824655009722424 NA NA NA 0.872054157469988 99.727107917785 a9533 gain_cnaBRCA16 1010 Gefitinib EGFR 15 30 -0.693147180559945 NA 1.35058357606661 1.42455493398474 -0.07397135791813 1.08087039496656 1.03405128518919 0.0704808605335075 0.0684368433649425 0.0715354827924189 0.824684233163637 NA NA NA 0.827880083680069 99.727107917785 a9534 gain_cnaBRCA9_(KRAS) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 4 39 0.693147180559945 NA 3.01061846191614 2.89793666598782 0.112681795928314 0.904055979064794 0.967870089606887 0.116969413608192 0.124640286152278 0.116422438443243 0.824803303146411 NA NA NA 0.825919111622148 99.727107917785 a9535 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1378 Bleomycin (50 uM) DNA damage 6 42 3.91202300542815 NA 3.97416500216626 3.78965370045698 0.184511301709275 1.89927329239451 1.89929374154532 0.0971474362312193 0.0971483685092275 0.0971473225406154 0.824837904649418 NA NA NA 0.830667698660223 99.727107917785 a9536 loss_cnaBRCA38 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 3 40 -1.38629436111989 0.693147180559945 -2.33955858608044 -2.21158259249976 -0.127975993580679 0.732397797636962 0.970199899442708 0.133312844472763 0.174735634096097 0.13190683039051 0.824871506381403 NA NA NA 0.79745310497838 99.727107917785 a9537 BRCA2_mut 1069 EHT 1864 Rac GTPases 5 41 2.30258509299405 NA 3.64269051748057 3.55151086045075 0.0911796570298242 0.890288194938512 0.862526623976351 0.105399380710851 0.102415889088725 0.105712281215709 0.824951893903848 NA NA NA 0.836900567010518 99.727107917785 a9538 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1192 GSK269962A ROCK1, ROCK2 6 40 1.6094379124341 NA 2.79274852911882 2.64922290446038 0.143525624658436 1.42807796046648 1.48027723266287 0.0973425598994402 0.100502653658735 0.0969586111922069 0.825073364338025 NA NA NA 0.826086788629416 99.727107917785 a9539 loss_cnaBRCA22_(SYNCRIP,ZNF292) 260 NG-25 MAP3K7 (TAK1) 19 30 2.32630161961136 NA 3.15672310229521 3.24103626284939 -0.0843131605541809 1.26734548860861 1.31040588487369 0.0651527739357304 0.06652736867099 0.0643412560393894 0.825109744633651 NA NA NA 0.823974450763261 99.727107917785 a9540 gain_cnaBRCA62 89 Parthenolide NFKB1 5 9 1.6094379124341 NA 3.36688579741164 3.18485444102748 0.18203135638416 1.42020200906791 1.45812452122244 0.125921474577468 0.128172862185731 0.124839376702582 0.825189343045609 NA NA NA 0.825281293225032 99.727107917785 a9541 PTEN_mut 269 NSC-207895 MDM4 9 40 2.99573227355399 NA 4.52397030426582 4.62193612092155 -0.0979658166557291 1.47919656762096 1.12933355964426 0.0819020784712115 0.0662290724574158 0.0867465735159664 0.82527762765283 NA NA NA 0.855469979553469 99.727107917785 a9542 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1067 CCT007093 PPM1D 6 40 1.88706964903238 NA 4.00169797881185 4.09822696067042 -0.0965289818585759 0.649718672747606 1.02866001751198 0.0972183760761116 0.148570428875567 0.093839539026753 0.82529279904105 NA NA NA 0.763219015142335 99.727107917785 a9543 loss_cnaBRCA34 167 OSU-03012 PDPK1 (PDK1) 5 43 2.77258872223978 NA 2.1359352349063 2.26100737557012 -0.12507214066382 0.421161679714932 1.24110852043622 0.104890607590281 0.296969422166986 0.10077454034387 0.825303585830753 NA NA NA 0.646351460317988 99.727107917785 a9544 loss_cnaBRCA23 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 3 45 2.77258872223978 NA -0.61245474898183 -0.424798698375556 -0.187656050606274 0.307231205062106 1.44817151184559 0.132358354335117 0.610797495548475 0.12958137145449 0.825318453236038 NA NA NA 0.51544225698397 99.727107917785 a9545 loss_cnaBRCA29_(MAP2K4) 197 Bryostatin 1 PRKC 7 41 -4.8283137373023 NA -2.88224670358207 -2.7939234483725 -0.0883232552095667 1.14075280959897 0.945545631131333 0.0907526651919127 0.0774254110674656 0.0934098284647449 0.825365081503891 NA NA NA 0.851496750115399 99.727107917785 a9546 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1199 Tamoxifen ER 15 32 1.6094379124341 NA 3.91456039322261 3.84789357967024 0.066666813552362 0.921613076674143 0.976804294035998 0.0694464940782342 0.0723370959458874 0.0682499185961863 0.825370119643712 NA NA NA 0.822208997126084 99.727107917785 a9547 loss_cnaBRCA22_(SYNCRIP,ZNF292) 29 AZ628 BRAF 4 10 1.38629436111989 NA 2.68716497799715 2.40565660825259 0.281508369744557 1.36306748818496 2.30649123981073 0.133381621275258 0.206525628543463 0.122050482952477 0.825418431168184 NA NA NA 0.783920938529578 99.727107917785 a9548 loss_cnaBRCA18 1050 ZM-447439 AURKB 12 27 1.38629436111989 0.693147180559945 2.81704222124171 2.91942713058902 -0.102384909347307 1.43599811202294 1.28041108940784 0.0770639177250448 0.0712987771293611 0.0799625293737946 0.825440546967052 NA NA NA 0.834111512034413 99.727107917785 a9549 loss_cnaBRCA36_(FAT1,IRF2) 1149 TW 37 BCL2, BCL2L1 9 34 1.6094379124341 NA -0.225055178576903 -0.120500759177894 -0.104554419399009 0.875084638524942 1.33308287968438 0.0831849282125815 0.119479207834397 0.0784305469617639 0.825487863061017 NA NA NA 0.780891554010693 99.727107917785 a9550 gain_cnaBRCA58_(CCND1) 1004 Vinblastine Microtubules 9 36 -2.30258509299405 NA -3.54103561615503 -3.43419154052409 -0.106844075630935 1.35200942797062 1.27910442929107 0.082634009679259 0.0790261320820147 0.0835303773360806 0.82557351323294 NA NA NA 0.833950039924106 99.727107917785 a9551 loss_cnaBRCA22_(SYNCRIP,ZNF292) 54 CGP-082996 CDK4 3 9 1.63315443905142 NA 2.689788191377 2.84885427260515 -0.159066081228154 1.28601784914192 0.988496539383644 0.15081122926378 0.123688859633083 0.160917185736772 0.825589572056869 NA NA NA 0.857926914673871 99.727107917785 a9552 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1262 UNC1215 LMBL3 6 40 0 NA 2.80800357700725 2.7499478197715 0.0580557572357439 0.442669757571955 0.615490833128989 0.0970229923274908 0.13114913825191 0.0943243247679321 0.825638073673284 NA NA NA 0.784278245019197 99.727107917785 a9553 MLL3_mut 206 Ruxolitinib JAK1, JAK2, TYK2 3 46 1.65632149833295 0.0237165266173161 4.28875462837468 4.37557604954544 -0.0868214211707663 0.790391552859682 0.651418240070088 0.131961433271121 0.109846089392835 0.133280611180652 0.825696336241499 NA NA NA 0.868201582183082 99.727107917785 a9554 gain_cnaBRCA64_(SDHC) 261 TL-1-85 MAP3K7 (TAK1) 8 41 2.32630161961136 NA 4.11213265917951 4.00776720872577 0.104365450453744 1.86547668525101 1.06805174122438 0.0855243011556861 0.0559457275874243 0.0977157252083153 0.825838415079129 NA NA NA 0.881913568782039 99.727107917785 a9555 loss_cnaBRCA42 170 Shikonin unknown 3 44 2.77258872223978 NA 0.151305744647184 -0.00646229317588915 0.157768037823073 0.606566616933638 1.21567456236927 0.131999944326334 0.260100100168114 0.12977818464474 0.825926867740979 NA NA NA 0.714691823146962 99.727107917785 a9556 BRCA2_mut 298 OSI-930 KIT, VEGFR, PDGFR 6 42 2.32630161961136 NA 3.83907457826499 3.92398054189612 -0.0849059636311247 1.07586914901203 0.853080510083153 0.0964804301794972 0.0789184853093832 0.0995286642087844 0.826020612600398 NA NA NA 0.859261511430601 99.727107917785 a9557 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1043 JNK Inhibitor VIII JNK 8 35 2.30258509299405 NA 4.85037920737775 4.78520591804474 0.0651732893330133 0.435632841617862 0.801644950555738 0.0866809184410852 0.149606005577934 0.0812994447078249 0.826041307242866 NA NA NA 0.75407095430227 99.727107917785 a9558 ARID1A_mut 275 I-BET BRD2, BRD3, BRD4 5 44 2.99573227355399 NA 4.16709508128227 4.02437810229195 0.142716978990311 1.1123862315348 1.39010273772307 0.10427474684612 0.128298045179325 0.10266649731521 0.826089059076638 NA NA NA 0.801060821266021 99.727107917785 a9559 loss_cnaBRCA22_(SYNCRIP,ZNF292) 186 Bexarotene Retinioic acid X family agonist 18 29 2.07944154167984 NA 3.6513436299812 3.5752714270725 0.0760722029086978 1.51578546406348 0.851098799166913 0.0662449091628585 0.0501866555078088 0.089381165833109 0.826270643220137 NA NA NA 0.847266217074911 99.727107917785 a9560 loss_cnaBRCA57 1023 GW 441756 NTRK1 5 40 0.693147180559945 NA 2.48139305583854 2.34402350777674 0.137369548061807 0.970761747578575 1.3415553867952 0.104742889956677 0.141506964406514 0.102395733649108 0.826279786082885 NA NA NA 0.785582918921087 99.727107917785 a9561 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 293 MP470 PDGFR 9 39 2.99573227355399 NA 3.6430555817673 3.50586123555695 0.137194346210345 1.32753502897312 1.74678055209628 0.0815955790529457 0.103345179762577 0.0785412604037186 0.826343119637544 NA NA NA 0.796794406176446 99.727107917785 a9562 gain_cnaBRCA13_(FGFR1,WHSC1L1) 326 GSK690693 AKT 11 37 2.32630161961136 NA 3.05301366464234 2.90585420846984 0.147159456172493 1.96910263572973 1.93616901954698 0.0757236159170399 0.0747342741319107 0.0760054802482715 0.826457777894478 NA NA NA 0.829805658147043 99.727107917785 a9563 loss_cnaBRCA28_(GPS2) 345 KIN001-270 CDK9 4 45 2.99573227355399 NA 5.03417224196606 5.11411274339538 -0.0799405014293155 0.243747215473503 0.715550133127706 0.115010676138645 0.327964778075611 0.111718938657577 0.826488783597057 NA NA NA 0.633427540395114 99.727107917785 a9564 gain_cnaBRCA31 86 A-443654 AKT1, AKT2, AKT3 3 9 0.0237165266173161 NA -1.12972107537613 -1.32359911310855 0.193878037732417 0.51500659316719 1.42223375170039 0.149971418300608 0.376457389681372 0.136319390185067 0.826542913813067 NA NA NA 0.736479802609347 99.727107917785 a9565 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1072 BMS-708163 g-secretase 18 28 1.6094379124341 NA 3.72323972542239 3.65918479686925 0.0640549285531451 0.994403822662777 0.940977785156781 0.0665871397921294 0.0644154086029368 0.0680727319640947 0.826573182024426 NA NA NA 0.82891461966991 99.727107917785 a9566 gain_cnaBRCA14_(RAD21) 1203 QL-XII-61 BTK 10 13 2.30258509299405 NA 4.144383806943 4.28738583124407 -0.143002024301074 1.76519430370049 1.3330358978225 0.0932681579053701 0.0810120585599499 0.107275448871756 0.826659518069758 NA NA NA 0.83352443797624 99.727107917785 a9567 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1259 BMN-673 PARP1 6 40 2.30258509299405 NA 3.43705479139279 3.28581052786217 0.151244263530617 0.909549326145296 1.63381698082459 0.0964292150448931 0.166284839296838 0.0925711173930171 0.82668758785223 NA NA NA 0.74457726371624 99.727107917785 a9568 gain_cnaBRCA64_(SDHC) 150 Bicalutamide ANDR (androgen receptor) 8 40 0.0237165266173161 NA 2.71797236635398 2.77151081887245 -0.0535384525184743 0.963537794549902 0.546183482724046 0.0852722658119154 0.055564455095904 0.0980228333736048 0.826711398162844 NA NA NA 0.882725897407553 99.727107917785 a9569 gain_cnaBRCA16 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 14 29 0.693147180559945 NA 2.95499491534178 2.8859336209105 0.0690612944312812 1.172921657469 0.848647050552192 0.071688151043014 0.0588797162977668 0.081378111650002 0.826745864721123 NA NA NA 0.845961794513659 99.727107917785 a9570 gain_cnaBRCA58_(CCND1) 1039 SL 0101-1 RSK, AURKB, PIM3 8 35 2.30258509299405 NA 4.71709547709937 4.63322444648301 0.083871030616363 1.21609887019826 0.913574621193889 0.0862946841848641 0.06896727944718 0.0918053420822457 0.826803666055076 NA NA NA 0.858455472095923 99.727107917785 a9571 ARID1A_mut 172 Embelin XIAP 5 43 3.46573590279973 NA 3.0837569679649 2.98251627419564 0.101240693769263 1.48040213289894 0.911951010586505 0.103875684242751 0.0683872925601723 0.111015496001426 0.82696619190643 NA NA NA 0.887709759100039 99.727107917785 a9572 gain_cnaBRCA62 304 SB52334 ALK5 10 39 2.99573227355399 NA 4.22240146388354 4.32227387190716 -0.0998724080236215 1.08152798802238 1.32525027479464 0.0778931824580401 0.0923438035165806 0.0753611675644417 0.827015624258471 NA NA NA 0.807061193144553 99.727107917785 a9573 gain_cnaBRCA14_(RAD21) 262 VX-11e ERK 21 28 1.63315443905142 NA 3.82537172047434 3.74039211270026 0.0849796077740819 1.17349464159991 1.4508032723132 0.0634255068063677 0.0724158464483681 0.0585741770754269 0.827046630344181 NA NA NA 0.821791192734974 99.727107917785 a9574 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 238 CAL-101 PI3Kdelta 7 42 2.99573227355399 2.32630161961136 4.64582875035208 4.73115346427868 -0.0853247139265951 1.15648562633666 0.918262960502071 0.089626855603723 0.0737793120670888 0.0929196946808601 0.827180079950374 NA NA NA 0.857732599791226 99.727107917785 a9575 ARID1A_mut 204 Tipifarnib Farnesyl-transferase (FNTA) 5 43 2.77258872223978 NA 1.47845973496064 1.63643196849443 -0.157972233533786 1.49080873398482 1.52793912189639 0.103605586621439 0.105964118624083 0.103389088786286 0.827408790169146 NA NA NA 0.831810850018037 99.727107917785 a9576 loss_cnaBRCA28_(GPS2) 1016 Temsirolimus MTOR 3 41 -1.6094379124341 NA -1.56630697319315 -1.76445076296325 0.1981437897701 1.8513597840287 1.49094317473902 0.131216032437325 0.107026085085917 0.132898284205086 0.827410466714677 NA NA NA 0.871638679566188 99.727107917785 a9577 TP53_mut 229 LY317615 PRKCB (PKCbeta) 38 11 2.99573227355399 2.32630161961136 3.33120531415964 3.45316078092819 -0.121955466768555 1.63799449811799 1.57617898283326 0.0750477076013667 0.0744541370002638 0.077374123178152 0.827448512309065 NA NA NA 0.825471224680382 99.727107917785 a9578 loss_cnaBRCA7_(FAS,PTEN) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 4 45 3.68887945411394 NA 3.33309862699204 3.47069061593949 -0.137591988947452 1.90419675918765 1.14010528186164 0.114330331938416 0.0722572330215233 0.120683581715174 0.82749847894787 NA NA NA 0.895375411706607 99.727107917785 a9579 gain_cnaBRCA9_(KRAS) 308 XL-880 MET 4 45 1.63315443905142 NA 1.67813133498692 1.86280457080308 -0.184673235816162 0.552540186910487 1.66334150993815 0.114318753646524 0.334225890154266 0.111025447698368 0.827515664784033 NA NA NA 0.630327715954173 99.727107917785 a9580 loss_cnaBRCA29_(MAP2K4) 293 MP470 PDGFR 7 41 2.99573227355399 NA 3.66025526952691 3.50961711063265 0.150638158894266 1.93263906147644 1.6404069500398 0.0895905373380059 0.0779442793519788 0.0918297492525322 0.827564831848496 NA NA NA 0.850840058316107 99.727107917785 a9581 loss_cnaBRCA42 208 SB-715992 KIF11 3 46 -2.05572501506252 NA -1.02930628228955 -1.25363360973731 0.224327327447758 0.54389554373068 1.75391382393025 0.130433905747126 0.412445606575586 0.127900997407658 0.827681130640188 NA NA NA 0.602910292993657 99.727107917785 a9582 loss_cnaBRCA29_(MAP2K4) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 5 38 1.6094379124341 NA 3.00044394802348 2.850526719149 0.149917228874481 1.59799747886797 1.42022471066237 0.104215151378873 0.0938156854794805 0.105558808932822 0.827686152018404 NA NA NA 0.849816747802428 99.727107917785 a9583 gain_cnaBRCA8_(CHD4,WNK1) 201 Epothilone B Microtubules 3 45 -3.44201937618241 NA -4.45814263061412 -4.220932277717 -0.237210352897121 2.03741962895573 1.80664306960988 0.130529982691245 0.116426851653875 0.131298958210015 0.827692093825221 NA NA NA 0.860746220001743 99.727107917785 a9584 gain_cnaBRCA61_(NOTCH2) 329 QL-XI-92 DDR1 3 45 2.32630161961136 NA 4.36992463384142 4.24556246248274 0.124362171358685 0.698412177039426 0.963333150671652 0.130447976526381 0.178064151008731 0.129095704089471 0.827798594683624 NA NA NA 0.793485431147447 99.727107917785 a9585 gain_cnaBRCA9_(KRAS) 202 GSK-1904529A IGF1R 4 44 0.0237165266173161 NA 2.10186017122905 2.19765753887297 -0.095797367643927 1.10460271729679 0.816967551013404 0.114216005996332 0.086725630983748 0.1172596971876 0.827845761348559 NA NA NA 0.875405700524039 99.727107917785 a9586 PTEN_mut 196 Phenformin AAPK1 (AMPK) agonist 9 39 8.29404964010203 NA 7.0821682512677 7.22966958392339 -0.14750133265569 1.61130547469798 1.86612946583867 0.0808505210231453 0.0915415077847591 0.0790413180627851 0.827903049961242 NA NA NA 0.813962527974396 99.727107917785 a9587 gain_cnaBRCA15 256 JW-7-24-1 LCK 22 26 2.32630161961136 NA 1.87772521474921 1.80359090193161 0.0741343128175975 1.31843846125365 1.03315698838041 0.0632523560530737 0.0562288760501619 0.0717551288442728 0.828121885475946 NA NA NA 0.831687776615883 99.727107917785 a9588 MLL3_mut 1030 KU-55933 ATM 3 39 2.30258509299405 NA 4.33532185185387 4.21360531683204 0.121716535021831 1.23599193436852 0.910817613582214 0.130908792482767 0.0984768036403225 0.133634366756616 0.828156131834745 NA NA NA 0.881570670439211 99.727107917785 a9589 PIK3CA_mut 175 PAC-1 CASP3 agonist 17 31 0.940007258491471 NA 2.45374311858067 2.37266752936316 0.0810755892175106 1.29036000884093 1.19859100934725 0.0658462333306134 0.0628317590920514 0.0676424139554192 0.828253633942981 NA NA NA 0.832379326950055 99.727107917785 a9590 loss_cnaBRCA18 229 LY317615 PRKCB (PKCbeta) 16 33 2.99573227355399 2.32630161961136 3.43130081710408 3.32332598347307 0.107974833631013 1.60656794939248 1.6336376615755 0.0664441140153371 0.0672083827340406 0.0660947260036113 0.828287706260104 NA NA NA 0.827808704360173 99.727107917785 a9591 loss_cnaBRCA34 261 TL-1-85 MAP3K7 (TAK1) 5 44 2.32630161961136 NA 3.91203590883185 4.03762130197803 -0.125585393146176 0.436690265605087 1.26884592494476 0.1029118533231 0.287584594935182 0.0989760779281719 0.828325335017717 NA NA NA 0.652926962247721 99.727107917785 a9592 POLR2B_mut 1495 AZD-2281 PARP1, PARP2 3 42 2.30258509299405 NA 3.86017148873762 4.00858556897087 -0.148414080233247 2.17256297924748 1.06253489907149 0.130368180427156 0.0683129012373457 0.139679252288975 0.828346029446383 NA NA NA 0.917006258434027 99.727107917785 a9593 TP53_mut 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 38 10 2.07944154167984 NA 3.19543101207096 3.28601871804841 -0.0905877059774456 1.2387650095525 0.824185478989229 0.0774733450892087 0.0731274335962799 0.109911795690142 0.828406147163844 NA NA NA 0.785802400979233 99.727107917785 a9594 gain_cnaBRCA9_(KRAS) 205 BMS-708163 g-secretase 4 44 2.32630161961136 0.940007258491471 4.82520790739051 4.90301330036772 -0.0778053929772149 0.775739100763738 0.676939651452153 0.113780790376098 0.10029840303346 0.114936970836778 0.828491197744498 NA NA NA 0.857117905291186 99.727107917785 a9595 loss_cnaBRCA23 279 BIX02189 MAP2K5 (MEK5) 3 46 2.99573227355399 NA 5.13779037979788 5.02015380528964 0.117636574508244 0.330201839608657 0.923528872463965 0.129808848814411 0.356256569156799 0.127377256971285 0.828493627399858 NA NA NA 0.639122278499756 99.727107917785 a9596 gain_cnaBRCA14_(RAD21) 277 ABT-869 VEGFR and PDGFR family 21 27 0.0237165266173161 NA 2.708139452739 2.67780842195803 0.0303310307809652 0.483691808455431 0.47499720776223 0.0633484316898536 0.0627073484618667 0.06385517701011 0.828606909670357 NA NA NA 0.829069883901371 99.727107917785 a9597 gain_cnaBRCA15 1527 GDC0941 (rescreen) PI3K 20 25 1.38629436111989 NA 1.02293248153726 0.946834529224698 0.0760979523125617 1.37287910770167 0.969011377806582 0.0653279321562186 0.0554294634434032 0.0785315364251079 0.828646363408409 NA NA NA 0.835258585483431 99.727107917785 a9598 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 9 40 3.68887945411394 NA 3.5383412841165 3.44171001670492 0.0966312674115781 1.33350575204627 1.17501663088627 0.0802939803780128 0.0724640799361363 0.0822382125252924 0.828652717005543 NA NA NA 0.844699241597069 99.727107917785 a9599 gain_cnaBRCA14_(RAD21) 258 STF-62247 stimulates autophagy 21 28 2.32630161961136 NA 4.59610039735022 4.65689978640603 -0.0607993890558065 1.09215401489248 0.864560500352907 0.0628111182043974 0.0556692446548322 0.0703240421358467 0.828695047760696 NA NA NA 0.83449701663743 99.727107917785 a9600 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1021 Axitinib PDGFR, KIT, VEGFR 6 39 0.693147180559945 NA 2.55978744430887 2.44736177082503 0.112425673483846 0.77716157498817 1.22233663585375 0.0953375091286011 0.144661904425161 0.0919760319589223 0.828922631968198 NA NA NA 0.769572949578625 99.727107917785 a9601 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1371 PLX4720 (rescreen) BRAF 15 32 2.30258509299405 NA 4.75170932804125 4.68625891365492 0.0654504143863273 0.724540237999195 1.05355746178195 0.0679429058762949 0.0903337191693692 0.0621232507580808 0.829090058098189 NA NA NA 0.805500897344434 99.727107917785 a9602 BRCA2_mut 150 Bicalutamide ANDR (androgen receptor) 6 42 0.0237165266173161 NA 2.81456802886405 2.75516198839394 0.0594060404701131 0.440978911634415 0.646971264332049 0.0946162285366298 0.134714016708723 0.0918217604787216 0.829328293670036 NA NA NA 0.779854642563208 99.727107917785 a9603 loss_cnaBRCA34 1192 GSK269962A ROCK1, ROCK2 5 41 1.6094379124341 NA 2.53307732297917 2.68439074971298 -0.151313426733815 0.908596408707843 1.51952205548678 0.102621517678894 0.166535356384476 0.0995796185961526 0.82949109981018 NA NA NA 0.757030710641415 99.727107917785 a9604 loss_cnaBRCA42 157 JNK-9L JNK 3 44 1.63315443905142 NA 0.184513504163642 0.0470713973939036 0.137442106769738 0.444508936100023 1.08360112797632 0.129249667681313 0.309199873405495 0.126838283221815 0.829495567611019 NA NA NA 0.675293473961006 99.727107917785 a9605 loss_cnaBRCA34 134 Etoposide TOP2 5 42 2.77258872223978 NA 2.67620336073029 2.45339911789174 0.222804242838551 1.30553173090715 2.2414988589994 0.102454006918683 0.170661683330926 0.0993996681925638 0.82952562655901 NA NA NA 0.751991493459526 99.727107917785 a9606 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 62 BMS-536924 IGF1R 3 9 1.63315443905142 NA 3.28404114924526 3.12470356943346 0.159337579811795 1.47047757806743 0.960143237788882 0.147310106685839 0.108357707855161 0.165951884615398 0.82956594387939 NA NA NA 0.873379075143833 99.727107917785 a9607 gain_cnaBRCA27_(CLTC,PPM1D) 62 BMS-536924 IGF1R 3 9 1.63315443905142 NA 3.28404114924526 3.12470356943346 0.159337579811795 1.47047757806743 0.960143237788882 0.147310106685839 0.108357707855161 0.165951884615398 0.82956594387939 NA NA NA 0.873379075143833 99.727107917785 a9608 ARID1A_mut 151 QS11 ARFGAP 5 43 2.32630161961136 NA 3.89703134871835 3.74456832810876 0.152463020609589 1.92996266778704 1.44255355814146 0.102236728427171 0.0789979118012724 0.105689677689345 0.829652751616229 NA NA NA 0.871460210993273 99.727107917785 a9609 gain_cnaBRCA48 206 Ruxolitinib JAK1, JAK2, TYK2 5 44 1.65632149833295 0.0237165266173161 4.43057410820374 4.3634066277999 0.0671674804038398 0.430425515010621 0.675224414856893 0.102086613580487 0.156049021401955 0.0994743065060455 0.829680112504199 NA NA NA 0.767376617447283 99.727107917785 a9610 loss_cnaBRCA22_(SYNCRIP,ZNF292) 346 THZ-2-102-1 CDK7 19 29 0.916290731874155 2.99573227355399 -1.43382963857265 -1.27051046633455 -0.163319172238104 2.54279175968649 2.57522121419524 0.0637323138870056 0.064228292236656 0.0634194729904558 0.829996246732164 NA NA NA 0.829715615855202 99.727107917785 a9611 loss_cnaBRCA7_(FAS,PTEN) 341 EX-527 SIRT1 4 45 2.99573227355399 NA 5.70993269122438 5.63569284302044 0.074239848203935 0.435380181059464 0.671636902163674 0.112639608287719 0.170517289104153 0.110535689693005 0.830008944533321 NA NA NA 0.770844224148314 99.727107917785 a9612 gain_cnaBRCA19 299 OSI-027 MTORC1/2 4 44 2.99573227355399 NA 1.06241747464716 1.28774702626529 -0.225329551618123 2.59758908221966 1.95033401957336 0.112724239132111 0.0867456493255574 0.115533826183996 0.83005858833294 NA NA NA 0.875439771366517 99.727107917785 a9613 loss_cnaBRCA36_(FAT1,IRF2) 1230 IOX2 EGLN1 9 38 -2.30258509299405 NA 0.206869895163607 0.259550484791153 -0.052680589627546 0.487594918332662 0.68996245268616 0.0799952134403015 0.108041711771091 0.0763528354658287 0.83012782236386 NA NA NA 0.792799553901176 99.727107917785 a9614 gain_cnaBRCA19 1377 Afatinib (rescreen) ERBB2, EGFR 4 43 2.30258509299405 NA 3.04129811561606 2.81541613134099 0.225881984275071 2.14535027918911 1.99189072329498 0.11280070925338 0.105289092632672 0.113400791335289 0.830128207625749 NA NA NA 0.850663424118899 99.727107917785 a9615 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1373 Dabrafenib BRAF 9 37 2.30258509299405 NA 4.10835698460079 4.24042938349197 -0.132072398891179 1.60173272575048 1.65713019150302 0.0801801110273226 0.0824559533359704 0.0796994705475669 0.830195436203563 NA NA NA 0.829157646624665 99.727107917785 a9616 gain_cnaBRCA14_(RAD21) 133 Doxorubicin DNA intercalating 21 27 0.0237165266173161 NA -0.965469059657846 -1.08133736877091 0.115868309113062 1.73692713629292 1.92929848137239 0.0626952025483036 0.0667087908824758 0.0600572229915611 0.830346361528699 NA NA NA 0.828122949570013 99.727107917785 a9617 POLR2B_mut 134 Etoposide TOP2 3 44 2.77258872223978 NA 2.73875511730264 2.45926169098174 0.279493426320903 2.7105772295202 2.14650938568746 0.128521157322291 0.103112142785312 0.130208341125604 0.830441479816164 NA NA NA 0.876108518759694 99.727107917785 a9618 BRCA1_mut 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 4 42 2.30258509299405 NA 1.516337922757 1.40334986695461 0.112988055802394 0.69647764798325 1.02131731443705 0.1127042260695 0.162227827597292 0.110629727123223 0.830462276963298 NA NA NA 0.781144265123669 99.727107917785 a9619 loss_cnaBRCA60 172 Embelin XIAP 3 45 3.46573590279973 NA 2.87574870942252 3.00088307782154 -0.125134368399024 1.01093479464065 0.972972821229574 0.128388491817657 0.123780850221408 0.12861034313465 0.830474301016794 NA NA NA 0.85248884100692 99.727107917785 a9620 ARID1A_mut 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 38 1.38629436111989 0.693147180559945 3.3256069216665 3.44477956550062 -0.119172643834123 0.749198546507048 1.07355983979859 0.113206090358445 0.159066838009412 0.111006987609075 0.830580275760871 NA NA NA 0.786008032649346 99.727107917785 a9621 loss_cnaBRCA23 136 Mitomycin C DNA crosslinker 3 45 2.77258872223978 NA 0.0446871309656811 -0.146238113495684 0.190925244461365 0.816183997637833 1.51256758985772 0.12821712995967 0.233924268319317 0.126225925863798 0.830697028312536 NA NA NA 0.738899367710958 99.727107917785 a9622 BRCA1_mut 292 Masitinib KIT 4 44 2.99573227355399 NA 4.12325996228881 4.00006078312691 0.123199179161901 1.26020701727324 1.08495216604686 0.112281444812137 0.0977610642325034 0.113552636712815 0.830715680531865 NA NA NA 0.860592844721017 99.727107917785 a9623 PIK3CA_mut 104 Bortezomib Proteasome 4 10 -3.91202300542815 NA -4.73915471942269 -4.50493839139742 -0.23421632802527 2.13891878016545 1.69395423053609 0.129012912486304 0.109502207469118 0.138266030925255 0.831037641729363 NA NA NA 0.853112103401326 99.727107917785 a9624 gain_cnaBRCA16 326 GSK690693 AKT 16 32 2.32630161961136 NA 3.02466228042059 2.89703623555376 0.127626044866829 2.33869350462766 1.71986721443169 0.0656704708705174 0.0545715138021678 0.0742069177177736 0.831121626462236 NA NA NA 0.848109444278613 99.727107917785 a9625 gain_cnaBRCA8_(CHD4,WNK1) 287 KIN001-244 PDPK1 (PDK1) 4 45 2.99573227355399 NA 3.38065319599892 3.48676851704459 -0.106115321045668 0.925446168541831 0.950910148614207 0.11178209228882 0.114663958480553 0.111593425730405 0.831282911141749 NA NA NA 0.838340901600811 99.727107917785 a9626 gain_cnaBRCA63 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 37 -1.38629436111989 0.693147180559945 -0.45594305600688 -0.281466913786948 -0.174476142219932 3.24857086012424 1.44049551524497 0.102054719579201 0.053708584399867 0.121122308520524 0.831488914895961 NA NA NA 0.911082393166418 99.727107917785 a9627 MLL3_mut 268 YM155 BIRC5 (Survivin) 3 46 1.63315443905142 NA -3.78820038373745 -3.58301567273155 -0.205184711005906 1.2779521865905 1.62251936659641 0.127494563674986 0.160557423946608 0.126460562030964 0.831503554486164 NA NA NA 0.812074626312256 99.727107917785 a9628 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 271 VNLG/124 HDAC, RAR 15 34 1.63315443905142 NA 4.11378248368906 4.16805376236964 -0.054271278680579 0.93299881913966 0.765278693280136 0.0662783892127654 0.0581686466984211 0.0709170125303785 0.831608250980547 NA NA NA 0.844938188278632 99.727107917785 a9629 NF1_mut 1261 rTRAIL TR10A (DR4), TR10B (DR5) 5 42 -2.30258509299405 NA -0.046179146148959 -0.151847084948907 0.105667938799948 1.06889904578373 1.0422907484035 0.101148291828658 0.0988567996358072 0.101380482328757 0.831664393110732 NA NA NA 0.84239797247832 99.727107917785 a9630 gain_cnaBRCA62 35 NVP-TAE684 ALK 5 9 0.693147180559945 NA 1.6755253928775 1.82720862609026 -0.151683233212765 1.46478256531769 1.13030550051277 0.121175201074767 0.103553412502467 0.134196669081017 0.831664913287021 NA NA NA 0.84685899581632 99.727107917785 a9631 gain_cnaBRCA64_(SDHC) 225 Genentech Cpd 10 AURKA, AURKB 8 41 2.32630161961136 NA 2.90597098827595 3.03993514612885 -0.133964157852899 1.87334402097212 1.57745394239244 0.0824424752351479 0.0715107083126046 0.084924291133168 0.83201588884197 NA NA NA 0.853831228534288 99.727107917785 a9632 gain_cnaBRCA8_(CHD4,WNK1) 1377 Afatinib (rescreen) ERBB2, EGFR 3 44 2.30258509299405 NA 3.07298390659585 2.81838941796226 0.254594488633588 2.85447033318081 1.95386714558672 0.127137481625505 0.0891914992684079 0.130302865887607 0.832238769928103 NA NA NA 0.892324726865845 99.727107917785 a9633 loss_cnaBRCA57 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 37 -1.38629436111989 0.693147180559945 -0.149261230027326 -0.322910403784185 0.173649173756859 0.599701401469644 1.79100015036724 0.101570457718752 0.289559392943404 0.0969565377877005 0.832276161318127 NA NA NA 0.66840129856813 99.727107917785 a9634 loss_cnaBRCA7_(FAS,PTEN) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 39 1.6094379124341 NA 2.73124731060095 2.55053053482085 0.180716775780103 0.594946010053699 1.67037912881354 0.111820022392278 0.30375323596807 0.108189076756763 0.832394670072506 NA NA NA 0.661770864620042 99.727107917785 a9635 loss_cnaBRCA42 283 GSK2126458 PI3K, MTOR 3 45 -2.05572501506252 0.0237165266173161 -2.85960996911502 -3.06840776633322 0.208797797218197 0.184614101676635 1.68216178903548 0.126879621525221 1.13099592784045 0.12412468204852 0.832435934091774 NA NA NA 0.448534155450974 99.727107917785 a9636 gain_cnaBRCA15 330 XMD13-2 RIPK 22 26 2.32630161961136 NA 3.76191783669563 3.68641643539777 0.0755014012978625 1.29593178070902 1.16243414049392 0.0616245127402721 0.0582603208145375 0.0649511216745423 0.832476674288611 NA NA NA 0.834062958595575 99.727107917785 a9637 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 60 BI-2536 PLK1, PLK2, PLK3 3 9 -1.36257783450257 NA -1.67419265268567 -1.43907703795648 -0.235115614729191 1.81876180633223 1.57451050243925 0.144571042992229 0.129272351063569 0.149326164776257 0.832680342986522 NA NA NA 0.853772795863479 99.727107917785 a9638 gain_cnaBRCA27_(CLTC,PPM1D) 60 BI-2536 PLK1, PLK2, PLK3 3 9 -1.36257783450257 NA -1.67419265268567 -1.43907703795648 -0.235115614729191 1.81876180633223 1.57451050243925 0.144571042992229 0.129272351063569 0.149326164776257 0.832680342986522 NA NA NA 0.853772795863479 99.727107917785 a9639 loss_cnaBRCA42 235 QL-XII-47 BTK, BMX 3 46 2.32630161961136 NA 1.88801151183289 1.69634011110243 0.191671400730454 1.11280045365912 1.53002681022012 0.126547883826106 0.172242381911509 0.125273230148745 0.832735531404898 NA NA NA 0.799811604993184 99.727107917785 a9640 gain_cnaBRCA8_(CHD4,WNK1) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 3 40 0.693147180559945 NA 1.48278889037741 1.69688388149437 -0.214094991116964 0.811957523808692 1.71726939264879 0.127101998628196 0.263677575290758 0.124671756238976 0.832902678734309 NA NA NA 0.715295072138267 99.727107917785 a9641 ASH1L_mut 1377 Afatinib (rescreen) ERBB2, EGFR 3 44 2.30258509299405 NA 3.07199905489702 2.81845656694172 0.2535424879553 1.58586817537128 2.01981009190963 0.126611614749434 0.159876143485849 0.125527884512939 0.83292206961129 NA NA NA 0.813111351584595 99.727107917785 a9642 gain_cnaBRCA8_(CHD4,WNK1) 197 Bryostatin 1 PRKC 3 45 -4.8283137373023 NA -2.69140237294519 -2.81449735976692 0.123094986821731 0.370377866702481 0.99201163089115 0.126474979102988 0.332349737627845 0.124086233455903 0.83296218040041 NA NA NA 0.658800853714698 99.727107917785 a9643 loss_cnaBRCA28_(GPS2) 1239 YK 4-279 RNA helicase A 3 39 2.30258509299405 NA 1.8596041112373 2.0253950931426 -0.165790981905302 1.24401824952395 1.30827264896114 0.12702975104191 0.133270538409502 0.126725099723634 0.833169283990155 NA NA NA 0.842403002307166 99.727107917785 a9644 loss_cnaBRCA60 1239 YK 4-279 RNA helicase A 3 39 2.30258509299405 NA 1.8596041112373 2.0253950931426 -0.165790981905302 1.24401824952395 1.30827264896114 0.12702975104191 0.133270538409502 0.126725099723634 0.833169283990155 NA NA NA 0.842403002307166 99.727107917785 a9645 gain_cnaBRCA8_(CHD4,WNK1) 1022 AZD7762 CHEK1, CHEK2 3 42 0.693147180559945 NA 0.71156068290027 0.918549971526856 -0.206989288626586 1.64264199442081 1.63466488180142 0.126596105975868 0.126009982290493 0.126624906995298 0.833236032520737 NA NA NA 0.850242194994955 99.727107917785 a9646 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1495 AZD-2281 PARP1, PARP2 6 39 2.30258509299405 NA 3.90714717912204 4.01277500739121 -0.105627828269171 0.656608889732136 1.18739251857526 0.0927813312707869 0.160868714878749 0.0889578017519535 0.833439014082358 NA NA NA 0.753964846356504 99.727107917785 a9647 loss_cnaBRCA34 1243 piperlongumine Increases ROS levels 5 42 2.30258509299405 NA 1.63337854924346 1.71939819927788 -0.0860196500344206 0.548892697625485 0.884242484919156 0.100052301284779 0.156714874157631 0.0972806119378953 0.833460625906606 NA NA NA 0.768560816219885 99.727107917785 a9648 BRCA2_mut 204 Tipifarnib Farnesyl-transferase (FNTA) 6 42 2.77258872223978 NA 1.49708634077318 1.63753226846249 -0.140445927689311 1.08087318750342 1.57038091447634 0.0921074740501299 0.129937470290766 0.0894343062849464 0.833784540867367 NA NA NA 0.787021052062244 99.727107917785 a9649 gain_cnaBRCA63 208 SB-715992 KIF11 7 42 -2.05572501506252 NA -1.36687241199649 -1.21873709549546 -0.148135316501023 2.65242465058964 1.53669889306597 0.0861293584406446 0.0558490196764279 0.0963984012544372 0.833820434279675 NA NA NA 0.889899090168097 99.727107917785 a9650 gain_cnaBRCA12_(TERT) 302 PI-103 PI3Ka, PRKDC (DNAPK) 9 39 2.32630161961136 NA 1.01035528239808 1.15568190025243 -0.145326617854352 1.65046340386261 1.90963525365148 0.077833480706193 0.0880520086142119 0.0761017673801678 0.834226944694473 NA NA NA 0.820880313876117 99.727107917785 a9651 loss_cnaBRCA38 286 KIN001-236 TIE2 4 45 2.32630161961136 NA 4.46226749401534 4.54702279067735 -0.0847552966620118 0.602037250599028 0.782623796206424 0.109735543828305 0.140780818093366 0.108296345029173 0.834325204711441 NA NA NA 0.80599253629252 99.727107917785 a9652 gain_cnaBRCA47_(EGFR) 290 KIN001-260 IKK 7 42 2.99573227355399 NA 4.96686102375037 5.05694240355511 -0.0900813798047428 0.853772281715827 1.07478060672883 0.0858602920085972 0.105509843472203 0.0838137376509904 0.834331798069788 NA NA NA 0.809204243402357 99.727107917785 a9653 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 266 Zibotentan, ZD4054 Endothelin A Receptor 6 43 2.99573227355399 NA 5.70215862090608 5.74760414221419 -0.0454455213081024 0.414992848482005 0.504644512761278 0.0916465520620206 0.109509167385262 0.0900545238457797 0.834346843871139 NA NA NA 0.813833316409558 99.727107917785 a9654 gain_cnaBRCA47_(EGFR) 1019 Bosutinib SRC, ABL, TEC 7 38 0.693147180559945 NA 2.59385731640034 2.67526139379334 -0.0814040773929925 0.816297677565116 0.959914210133772 0.0864904791905667 0.0997235195324917 0.0848034923679775 0.834440554330509 NA NA NA 0.81886650743039 99.727107917785 a9655 gain_cnaBRCA64_(SDHC) 1031 Elesclomol HSP70 9 35 -1.6094379124341 NA -2.86513727258958 -3.0064926757659 0.141355403176322 2.17451974855909 1.69882080321021 0.0785677334211003 0.0650053434879076 0.0832079539579497 0.834512815619 NA NA NA 0.859532186890231 99.727107917785 a9656 loss_cnaBRCA20 173 FH535 unknown 3 45 3.46573590279973 NA 1.72423342125212 1.56291571346028 0.161317707791844 1.34749213646477 1.28653236200621 0.125125939995496 0.119716993833501 0.125389545227053 0.834717192510523 NA NA NA 0.857200589833242 99.727107917785 a9657 gain_cnaBRCA8_(CHD4,WNK1) 1133 JNJ-26854165 MDM2 3 40 2.30258509299405 NA 3.07161008117321 2.96110620832321 0.110503872849998 0.459435071863659 0.895530127885782 0.125674041692653 0.240521195740996 0.123394924870793 0.834751746380484 NA NA NA 0.735633439697464 99.727107917785 a9658 gain_cnaBRCA10_(MDM2,NUP107) 1218 JQ1 BRD2, BRD3, BRD4 3 43 0 NA 2.54082777035995 2.45220192561062 0.0886258447493251 0.45970607683095 0.716938700739403 0.125305387446108 0.192788064409068 0.123617046559102 0.834762157208184 NA NA NA 0.77953275159406 99.727107917785 a9659 gain_cnaBRCA8_(CHD4,WNK1) 1030 KU-55933 ATM 3 39 2.30258509299405 NA 4.33090749274786 4.21394488291712 0.116962609830738 0.491334750095865 0.947296219646583 0.125790093135544 0.238050758282245 0.123469942563873 0.834772875619601 NA NA NA 0.738264918405345 99.727107917785 a9660 loss_cnaBRCA33 1268 XAV 939 TNKS1 (tankyrase-1) 5 42 1.6094379124341 NA 3.74534123493166 3.6514547632481 0.0938864716835583 0.411947591808026 0.982775170060654 0.0992367333600937 0.22790877662737 0.0955319940345704 0.834797854406608 NA NA NA 0.701649411260676 99.727107917785 a9661 BRCA1_mut 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 3 23 2.30258509299405 NA 2.83446734474194 2.67290024714263 0.161567097599301 0.147448726530704 1.30324873650887 0.129409854101686 1.09575105462615 0.123972571830076 0.834809954292378 NA NA NA 0.575739096689241 99.727107917785 a9662 loss_cnaBRCA33 238 CAL-101 PI3Kdelta 6 43 2.99573227355399 2.32630161961136 4.6426339868589 4.72961494955851 -0.0869809626996068 1.01750459870975 0.943946926594716 0.0913624891484878 0.0854845892685919 0.0921460309356482 0.834852649974827 NA NA NA 0.849429079603272 99.727107917785 a9663 NF1_mut 226 GSK1070916 AURKB 5 44 0.940007258491471 2.32630161961136 2.57808957484706 2.38415886084132 0.193930714005742 1.04396929931638 2.02573003816131 0.0988735375706695 0.185762851582642 0.0957337406033467 0.834959891627271 NA NA NA 0.737076498315429 99.727107917785 a9664 gain_cnaBRCA12_(TERT) 258 STF-62247 stimulates autophagy 9 40 2.32630161961136 NA 4.56982807421432 4.64457124239487 -0.0747431681805528 0.832920219130134 0.993450669967019 0.0772133628925198 0.0897362874185133 0.0752359130051563 0.835127416198622 NA NA NA 0.818222400021467 99.727107917785 a9665 MLL3_mut 1248 FK866 NAMPT 3 41 0 NA -0.969900331014129 -0.627350178123572 -0.342550152890557 1.90652766783421 2.76995585226579 0.125245568494496 0.179672269471803 0.123666286092739 0.835143934823927 NA NA NA 0.79315810839514 99.727107917785 a9666 gain_cnaBRCA14_(RAD21) 1262 UNC1215 LMBL3 20 26 0 NA 2.77856059325061 2.74133547645736 0.0372251167932567 0.695252695306978 0.512713676887394 0.0622069587766947 0.0535418518252857 0.0726041033647564 0.835295022306717 NA NA NA 0.841861275537748 99.727107917785 a9667 TP53_mut 1049 PD-173074 FGFR1, FGFR3 34 9 0.693147180559945 NA 2.95667362661423 2.86632758453137 0.090346042082865 1.20622493413862 0.893265382001496 0.0784351767351509 0.0748998296469328 0.101141322504216 0.835299814142257 NA NA NA 0.806264399428116 99.727107917785 a9668 gain_cnaBRCA62 1028 VX-702 p38 8 37 0.693147180559945 NA 3.47300607733031 3.4168477246642 0.056158352666114 1.07083153879808 0.586538461883801 0.0815095516847706 0.0524436857072283 0.0957453880956908 0.835397185971589 NA NA NA 0.889287683065731 99.727107917785 a9669 loss_cnaBRCA34 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 5 38 1.6094379124341 NA 2.7415023484739 2.88459798224763 -0.143095633773722 1.26160914811467 1.45645812177474 0.0994679339570596 0.113423110467741 0.0982490547681216 0.835416224794067 NA NA NA 0.823483521698345 99.727107917785 a9670 gain_cnaBRCA8_(CHD4,WNK1) 1061 SB590885 BRAF 3 39 1.6094379124341 NA 4.13925131360936 4.00211634124599 0.137134972363364 0.480880653758106 1.1198749987796 0.125031569727192 0.285174650491025 0.122455606663965 0.835754435466485 NA NA NA 0.69959210349597 99.727107917785 a9671 gain_cnaBRCA19 1052 RO-3306 CDK1 3 40 1.6094379124341 NA 3.38500498530879 3.53622348880322 -0.151218503494431 0.507946084263632 1.23612560087012 0.124890597316775 0.297705815989608 0.122332636253134 0.83576663523828 NA NA NA 0.689306346306029 99.727107917785 a9672 gain_cnaBRCA16 29 AZ628 BRAF 3 11 1.38629436111989 NA 2.71465299831139 2.42375154541639 0.290901452894996 1.75134610967585 2.17590208744962 0.137797429812646 0.16610163535798 0.133692345153252 0.836000591684039 NA NA NA 0.821442377268192 99.727107917785 a9673 gain_cnaBRCA12_(TERT) 304 SB52334 ALK5 9 40 2.99573227355399 NA 4.38223809306313 4.28381382014117 0.0984242729219602 1.2498342398986 1.28878606885132 0.0767596616198644 0.0787498612055512 0.0763697523590435 0.836081971308427 NA NA NA 0.835453496919654 99.727107917785 a9674 gain_cnaBRCA9_(KRAS) 140 Vinorelbine Microtubules 4 43 -2.74887219562247 NA -3.43479013821702 -3.61516846247409 0.180378324257071 1.2188314727646 1.6852358155697 0.108777724847468 0.147992834356279 0.107034471134886 0.836096146928504 NA NA NA 0.798091462005591 99.727107917785 a9675 gain_cnaBRCA10_(MDM2,NUP107) 205 BMS-708163 g-secretase 5 43 2.32630161961136 0.940007258491471 4.95674962627525 4.88952717940385 0.0672224468713987 0.802917893438973 0.67140922399524 0.0983000674543334 0.0837226912249752 0.100121422925038 0.836114038084233 NA NA NA 0.864668788304731 99.727107917785 a9676 gain_cnaBRCA31 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 16 33 3.68887945411394 NA 3.40810712058663 3.48435631199573 -0.0762491914091057 1.16006831429691 1.22335830270955 0.0633550969778496 0.0657281907189391 0.0623277671310404 0.836151050659045 NA NA NA 0.833547214194749 99.727107917785 a9677 loss_cnaBRCA7_(FAS,PTEN) 202 GSK-1904529A IGF1R 4 44 0.0237165266173161 NA 2.10615865292032 2.19726676781013 -0.0911081148898116 0.637957803954956 0.851024440991029 0.108619773058624 0.142812133224166 0.107056989789524 0.836154124835585 NA NA NA 0.803981451676069 99.727107917785 a9678 loss_cnaBRCA24 287 KIN001-244 PDPK1 (PDK1) 3 46 2.99573227355399 NA 3.36769586369343 3.48530670565047 -0.117610841957045 0.0934797667204761 0.969998951082372 0.123887974540715 1.25814222781199 0.121248421790362 0.836199307254266 NA NA NA 0.446146905460719 99.727107917785 a9679 loss_cnaBRCA38 184 BMS-754807 IGF1R 4 44 0.940007258491471 NA 1.45866409673793 1.64216030540187 -0.183496208663939 0.68420262705956 1.73915141087266 0.10854308999183 0.268189862778714 0.105509047410579 0.836268104757764 NA NA NA 0.682444541206547 99.727107917785 a9680 gain_cnaBRCA16 309 Y-39983 ROCK 16 33 2.99573227355399 NA 4.98147502113979 4.91243833627628 0.0690366848635158 1.3386657755078 0.952849371429748 0.0632836231706294 0.0515712630640219 0.0724528838801944 0.836333196578412 NA NA NA 0.855009189311186 99.727107917785 a9681 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 5 21 2.30258509299405 NA 4.77026956013186 4.66567801168747 0.104591548444394 1.64347805888975 0.821815636189784 0.10391890348543 0.0636403679858378 0.12726887131196 0.836339658711741 NA NA NA 0.896030233914859 99.727107917785 a9682 gain_cnaBRCA63 265 Tubastatin A HDAC6 7 42 2.99573227355399 NA 4.61604545295831 4.70437850004325 -0.0883330470849382 1.57626556962707 0.938960845777424 0.0847524073549003 0.0560394446132812 0.0940753253793046 0.836438105002483 NA NA NA 0.889667534284148 99.727107917785 a9683 loss_cnaBRCA36_(FAT1,IRF2) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 9 34 1.6094379124341 NA 2.85253928880055 2.97062147323635 -0.118082184435796 1.20453154718968 1.58392494813314 0.0778205892626196 0.0980316245857537 0.0745503658964214 0.83657139812012 NA NA NA 0.810613998438241 99.727107917785 a9684 gain_cnaBRCA16 1149 TW 37 BCL2, BCL2L1 15 28 1.6094379124341 NA -0.0880709702564363 -0.171480638049785 0.0834096677933482 0.947684138628191 1.39053918886419 0.0663568345735694 0.0880142068369814 0.0599836872353652 0.836736297483564 NA NA NA 0.817542661478626 99.727107917785 a9685 loss_cnaBRCA60 1091 BMS-536924 IGF1R 3 44 1.38629436111989 NA 3.15094268841771 3.01459945992926 0.136343228488451 0.370500755475731 1.12494626953112 0.123674747224904 0.367997167275363 0.121199769430125 0.836740554665702 NA NA NA 0.637835740095384 99.727107917785 a9686 gain_cnaBRCA30_(CRNKL1,FOXA2) 263 FR-180204 ERK 5 44 2.99573227355399 NA 5.42267535589547 5.35052233635544 0.0721530195400328 1.03522490047072 0.704284284808478 0.0977354940285216 0.0696979173387588 0.10244871438478 0.836831799814179 NA NA NA 0.885931430750363 99.727107917785 a9687 gain_cnaBRCA14_(RAD21) 164 JQ12 HDAC 21 26 1.63315443905142 NA 1.52238567416964 1.62270807284208 -0.100322398672443 1.41740348169605 1.820267697263 0.0606771400560949 0.0707789983360266 0.05511409053915 0.83709084897264 NA NA NA 0.832759660010455 99.727107917785 a9688 BRCA2_mut 328 SNX-2112 HSP90 6 42 0.940007258491471 NA 0.25515382158819 0.440395118926707 -0.185241297338517 2.03175530897291 2.0571385958589 0.0901683080506797 0.0911730347254072 0.090048039403575 0.837232831100734 NA NA NA 0.841111419822332 99.727107917785 a9689 loss_cnaBRCA33 5 Sunitinib PDGFRA, PDGFRB, KDR, KIT, FLT3 4 8 2.07944154167984 NA 3.37936936691611 3.19342092841171 0.185948438504396 1.53043332927462 1.40006807190133 0.129093472307976 0.121500515538649 0.132813855437666 0.837270218381618 NA NA NA 0.845519995597941 99.727107917785 a9690 ARID1A_mut 1032 Afatinib ERBB2, EGFR 5 40 -0.693147180559945 NA 0.129840091095104 0.310550649307644 -0.18071055821254 1.88281557534198 1.84192133426346 0.0979055775167486 0.0959788948950652 0.0981098132971035 0.837450283137695 NA NA NA 0.847255696249232 99.727107917785 a9691 gain_cnaBRCA62 1262 UNC1215 LMBL3 8 38 0 NA 2.71784263305391 2.7658735049598 -0.0480308719058815 1.03029424821742 0.474367505081735 0.0802634093599236 0.046618596569847 0.101252449612048 0.837480109436621 NA NA NA 0.90068282537632 99.727107917785 a9692 loss_cnaBRCA17 1017 Olaparib PARP1, PARP2 8 37 1.6094379124341 NA 4.13337108588975 4.06128231661304 0.0720887692767063 0.527685496171296 0.951427920513793 0.0804377877963388 0.136613133769561 0.0757690285542352 0.837530111161018 NA NA NA 0.770445708880669 99.727107917785 a9693 gain_cnaBRCA15 329 QL-XI-92 DDR1 22 26 2.32630161961136 NA 4.22250050737262 4.27942590580961 -0.0569253984369888 0.967846017190879 0.941098727714001 0.0597076219597891 0.058816585929869 0.0604882322763998 0.837611526557712 NA NA NA 0.838028676553564 99.727107917785 a9694 loss_cnaBRCA34 226 GSK1070916 AURKB 5 44 0.940007258491471 2.32630161961136 2.57523620706817 2.38448310717983 0.190753099888342 0.756439350232302 2.03761264727398 0.0972519884585184 0.252172364948706 0.0936159775723523 0.837627382182902 NA NA NA 0.683416080484509 99.727107917785 a9695 gain_cnaBRCA48 177 GSK-650394 SGK3 5 42 2.77258872223978 NA 4.16322612825651 3.99672603539749 0.16650009285902 2.23363552436779 1.64807622239182 0.0974669014630343 0.0745421941237016 0.101026937102085 0.837701415129209 NA NA NA 0.878624991611795 99.727107917785 a9696 gain_cnaBRCA9_(KRAS) 1149 TW 37 BCL2, BCL2L1 3 40 1.6094379124341 NA 0.00175378336561732 -0.153194594233434 0.154948377599051 0.751279698574011 1.27754534354002 0.123268783931177 0.206245926641111 0.121286010224652 0.837868462714593 NA NA NA 0.767630474006289 99.727107917785 a9697 ASH1L_mut 222 BX-912 PDPK1 (PDK1) 3 46 2.32630161961136 NA 3.70857840867872 3.89520702146923 -0.186628612790514 0.918660022535459 1.54365125325303 0.122597113914113 0.203153079716507 0.120900762006457 0.837881473193736 NA NA NA 0.769052822838725 99.727107917785 a9698 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 253 XMD14-99 EPHB3, CAMK1 7 41 2.32630161961136 NA 4.87719103373267 4.94264758767254 -0.0654565539398622 1.13305673287384 0.710347321462117 0.0840686306418139 0.0577698821610113 0.0921472524245352 0.838035862102626 NA NA NA 0.886648159309679 99.727107917785 a9699 loss_cnaBRCA7_(FAS,PTEN) 345 KIN001-270 CDK9 4 45 2.99573227355399 NA 5.17600334681292 5.10150553407565 0.0744978127372642 0.353623138130554 0.712465399586197 0.107172974387589 0.210670074167376 0.10456341147308 0.838138195396673 NA NA NA 0.731408380077471 99.727107917785 a9700 gain_cnaBRCA64_(SDHC) 341 EX-527 SIRT1 8 41 2.99573227355399 NA 5.68549637350902 5.63321799299379 0.052278380515232 0.775200127086341 0.636637704293259 0.0793150171215893 0.0674385603001963 0.0821163750790838 0.83829579783743 NA NA NA 0.861693262957388 99.727107917785 a9701 TP53_mut 9 MG-132 Proteasome 9 5 0 NA 0.396966000405682 0.207032838882767 0.189933161522915 1.69099269069571 1.51026838931714 0.116311118220639 0.112320510057777 0.125761197722474 0.838314628337587 NA NA NA 0.833742016879429 99.727107917785 a9702 gain_cnaBRCA8_(CHD4,WNK1) 304 SB52334 ALK5 4 45 2.99573227355399 NA 4.17586286147078 4.31309431549626 -0.137231454025478 1.65499331055609 1.25281029480081 0.107023439529153 0.0829196427261494 0.109538893953053 0.838360818830482 NA NA NA 0.880858072289917 99.727107917785 a9703 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 303 PIK-93 PI4K, PI3K 6 43 2.99573227355399 NA 2.90384750714171 2.77585459862469 0.127992908517017 1.15920444143893 1.4609201002998 0.0893900190696915 0.11041443937028 0.0876111626438373 0.838366789457955 NA NA NA 0.813320657030456 99.727107917785 a9704 gain_cnaBRCA9_(KRAS) 203 BMS-345541 IKBKB 4 45 2.77258872223978 NA 3.63167293193488 3.5235018533043 0.108171078630582 0.766341458477468 1.0300187668126 0.1065476688275 0.141152586009755 0.105018551230205 0.839069222076971 NA NA NA 0.806122767299309 99.727107917785 a9705 gain_cnaBRCA8_(CHD4,WNK1) 1038 NU-7441 PRKDC (DNAPK) 3 40 0.693147180559945 NA 2.78451608904566 2.90099118516995 -0.116475096124296 0.281359791987805 0.974387534561422 0.122302255345482 0.413972072204772 0.1195367263978 0.839121630129552 NA NA NA 0.619093693978775 99.727107917785 a9706 loss_cnaBRCA24 223 ZSTK474 PI3K 3 46 1.63315443905142 2.32630161961136 0.745932912406256 0.923190464523375 -0.177257552117119 1.13766986741016 1.47039214241891 0.121594041790793 0.155807547685724 0.120551210118354 0.839189140502405 NA NA NA 0.817644640366064 99.727107917785 a9707 gain_cnaBRCA63 1114 Cetuximab EGFR 5 40 4.18661983833127 NA 6.35868921408832 6.27307203526367 0.0856171788246476 0.670352592530159 0.903516966306282 0.0968055605850854 0.127719620657387 0.0947599016039111 0.83925067847933 NA NA NA 0.805177553259521 99.727107917785 a9708 loss_cnaBRCA42 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 3 46 1.63315443905142 NA 3.69152493520724 3.56916550447527 0.122359430731964 0.855587584752355 1.01315044976535 0.12151514116516 0.143012162533167 0.120771234677241 0.839292019767786 NA NA NA 0.831454226347277 99.727107917785 a9709 loss_cnaBRCA60 283 GSK2126458 PI3K, MTOR 3 45 -2.05572501506252 0.0237165266173161 -2.86774665761946 -3.06786532043292 0.200118662813462 0.174533289707521 1.68227813064895 0.12160072255887 1.14659308346743 0.118956942474349 0.839307264790013 NA NA NA 0.463612130388104 99.727107917785 a9710 loss_cnaBRCA33 1529 MLN4924 NEDD8-activating enzyme 5 32 0 NA 0.223629310373391 0.391963078908533 -0.168333768535142 2.30882140759965 1.62296368929329 0.0981375503151265 0.0729089603817166 0.103719984399923 0.839475255438519 NA NA NA 0.881789611068592 99.727107917785 a9711 loss_cnaBRCA34 133 Doxorubicin DNA intercalating 5 43 0.0237165266173161 NA -1.18997610014938 -1.01211810950889 -0.177857990640491 1.40964206599199 1.88467415176289 0.0962320351524147 0.126172448262836 0.0943706849664837 0.839512935075282 NA NA NA 0.806247869419522 99.727107917785 a9712 gain_cnaBRCA8_(CHD4,WNK1) 1016 Temsirolimus MTOR 3 41 -1.6094379124341 NA -1.92243825398299 -1.73839237656399 -0.184045877419001 1.1494888268233 1.5259746156853 0.121870440851282 0.160111062521265 0.120608741146292 0.839523066923149 NA NA NA 0.81373387689077 99.727107917785 a9713 loss_cnaBRCA60 155 AP-24534 ABL 3 44 -0.669430653942629 NA 1.57540770255595 1.43649285580203 0.138914846753919 1.17683155942251 1.14141800137779 0.121533678955873 0.118041401627678 0.121703746205366 0.839526863284887 NA NA NA 0.859287131789581 99.727107917785 a9714 loss_cnaBRCA29_(MAP2K4) 1049 PD-173074 FGFR1, FGFR3 5 38 0.693147180559945 NA 3.03637553968485 2.92478878598005 0.111586753704797 0.505198294653672 1.20112384148839 0.0968728657445467 0.220877138513092 0.0929019555273524 0.839648904411527 NA NA NA 0.71520988390342 99.727107917785 a9715 gain_cnaBRCA48 1268 XAV 939 TNKS1 (tankyrase-1) 5 42 1.6094379124341 NA 3.58008337153612 3.67112831841424 -0.0910449468781174 0.576761828406469 0.974682722595171 0.096230475294485 0.157855361423042 0.0934098294424496 0.839731237047728 NA NA NA 0.769164440964348 99.727107917785 a9716 loss_cnaBRCA23 1502 Bicalutamide ANDR (androgen receptor) 3 42 2.30258509299405 NA 4.62502275658663 4.55353744554626 0.0714853110403721 0.300680591169857 0.598451066038072 0.121582996075017 0.237745012946278 0.119450553432258 0.839745194627091 NA NA NA 0.73838362195182 99.727107917785 a9717 loss_cnaBRCA60 194 AUY922 HSP90 3 44 -1.36257783450257 NA -2.59124754496235 -2.38028113366634 -0.210966411296004 1.13187410271013 1.76335637269364 0.121233682124191 0.18638681704164 0.119639123754513 0.839917435253817 NA NA NA 0.786331437550169 99.727107917785 a9718 gain_cnaBRCA16 222 BX-912 PDPK1 (PDK1) 16 33 2.32630161961136 NA 3.82034339712163 3.91453829877802 -0.0941949016563877 1.66812709696575 1.44891448163232 0.0618763175935276 0.0564674609193293 0.0650106702986841 0.839921447550116 NA NA NA 0.848230159293138 99.727107917785 a9719 PIK3CA_mut 32 VX-680 AURKA, AURKB, AURKC, FLT3, ABL1, JAK2 4 8 0.693147180559945 NA 1.37989186451633 1.0967659302915 0.283125934224828 2.81186044803249 1.9282593781562 0.126939372744671 0.100689895340623 0.146829797605109 0.839942821792692 NA NA NA 0.86413379829137 99.727107917785 a9720 PTEN_mut 1069 EHT 1864 Rac GTPases 8 38 2.30258509299405 NA 3.50494160657289 3.57331223719212 -0.0683706306192291 0.941582450514407 0.84993886060023 0.0790258339222744 0.0726124733759393 0.080441822098763 0.839950676511763 NA NA NA 0.853476783448819 99.727107917785 a9721 gain_cnaBRCA64_(SDHC) 197 Bryostatin 1 PRKC 8 40 -4.8283137373023 NA -2.8705339875588 -2.79405791019692 -0.0764760773618791 1.36984612491231 0.883502172694931 0.0785727200099992 0.0558282247699716 0.0865601463419218 0.840128306105296 NA NA NA 0.883072345974821 99.727107917785 a9722 loss_cnaBRCA18 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 12 30 1.38629436111989 0.693147180559945 3.48550228679478 3.41260079113841 0.0729014956563718 1.15690441841723 1.0104739483042 0.0692470105353132 0.0630142771484171 0.0721458438178604 0.840370284966502 NA NA NA 0.850595601527173 99.727107917785 a9723 CDH1_mut 1023 GW 441756 NTRK1 4 41 0.693147180559945 NA 2.23258224514452 2.37164820999229 -0.139065964847779 0.653334912402434 1.34808590777089 0.10602679531603 0.212855554184924 0.103158088105624 0.840551108873251 NA NA NA 0.732854203549834 99.727107917785 a9724 loss_cnaBRCA57 1149 TW 37 BCL2, BCL2L1 3 40 1.6094379124341 NA -0.000668555888602151 -0.153012918789368 0.152344362900765 1.0660325975182 1.2660354692045 0.121195077870495 0.142907790301567 0.120331828456978 0.840557677785245 NA NA NA 0.832205693030114 99.727107917785 a9725 BRCA2_mut 1218 JQ1 BRD2, BRD3, BRD4 5 41 0 NA 2.39755292559917 2.46535125571563 -0.0677983301164611 0.618406958024293 0.715586103695108 0.0958546402361491 0.109633841011533 0.0947451742933065 0.840572977958514 NA NA NA 0.828555612662043 99.727107917785 a9726 BRCA1_mut 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 4 44 2.07944154167984 NA 3.10110045692158 3.22459463207942 -0.123494175157837 1.54655823932882 1.13838918687428 0.105608358002911 0.0798509697322691 0.108481507538665 0.840632867979399 NA NA NA 0.885156488903454 99.727107917785 a9727 CDH1_mut 308 XL-880 MET 4 45 1.63315443905142 NA 1.69128351934028 1.86163548774945 -0.170351968409172 0.858300560235144 1.65460486157134 0.105445393853582 0.198475890965866 0.102956284225705 0.840710980992007 NA NA NA 0.744037788257915 99.727107917785 a9728 gain_cnaBRCA30_(CRNKL1,FOXA2) 1031 Elesclomol HSP70 5 39 -1.6094379124341 NA -3.13067713169717 -2.95795111401607 -0.172726017681097 1.53704501179305 1.82463276737273 0.0960002306600787 0.112375380262679 0.0946634417454878 0.840815418310853 NA NA NA 0.825393786854176 99.727107917785 a9729 loss_cnaBRCA7_(FAS,PTEN) 1239 YK 4-279 RNA helicase A 4 38 2.30258509299405 NA 1.88809473853939 2.02675900031884 -0.138664261779454 1.0208782838894 1.32558510713774 0.106239698894134 0.135828397927286 0.104606080011613 0.840856546615801 NA NA NA 0.814229622952179 99.727107917785 a9730 TP53_mut 1006 Cytarabine DNA synthesis 35 10 0.693147180559945 NA 1.23332391103795 1.12176604794005 0.111557863097906 1.52060988923281 1.61156194338166 0.0724358956970667 0.0733638942425859 0.0692234409952721 0.840858451623622 NA NA NA 0.847863042032272 99.727107917785 a9731 loss_cnaBRCA57 1194 SB-505124 TGFR1 (ALK5) 5 42 2.30258509299405 NA 4.31009530625033 4.39839239674441 -0.088297090494085 0.90324197065275 0.926840784846988 0.095480313300586 0.0977557436024312 0.0952667296666945 0.840963304682461 NA NA NA 0.84478556500575 99.727107917785 a9732 loss_cnaBRCA57 200 LAQ824 HDAC 5 43 0.0237165266173161 NA -2.56315675049484 -2.69857330051175 0.135416550016912 1.26484554986911 1.43481464781573 0.0953072469207374 0.107061727837778 0.0943791243162047 0.841033867974271 NA NA NA 0.831711699657572 99.727107917785 a9733 gain_cnaBRCA27_(CLTC,PPM1D) 290 KIN001-260 IKK 9 40 2.99573227355399 NA 4.98044768759181 5.05838947318103 -0.0779417855892195 0.577901858479348 1.12166475974459 0.0742866303809387 0.134870280213859 0.0694875941426271 0.841289397714077 NA NA NA 0.768539685590115 99.727107917785 a9734 gain_cnaBRCA64_(SDHC) 1052 RO-3306 CDK1 7 36 1.6094379124341 NA 3.61004693063907 3.5092673887106 0.100779541928471 1.11980481106821 1.22578008024172 0.0832303418304795 0.089997418239644 0.0822166582349728 0.841313880939828 NA NA NA 0.834966764640501 99.727107917785 a9735 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 173 FH535 unknown 6 42 3.46573590279973 NA 1.47388667411091 1.58715684106675 -0.113270166955838 0.631887000698185 1.34770065844011 0.0878545557441017 0.179256998214369 0.0840469775290767 0.841351447475371 NA NA NA 0.737953554282381 99.727107917785 a9736 gain_cnaBRCA19 230 GSK429286A ROCK2 4 45 2.99573227355399 2.32630161961136 5.31858270765254 5.41322988631441 -0.0946471786618739 1.23542597676704 0.876083909240999 0.104779132042745 0.076610966939156 0.108034376232149 0.841703677174676 NA NA NA 0.889603673821819 99.727107917785 a9737 gain_cnaBRCA16 178 BAY 61-3606 SYK 16 32 2.07944154167984 NA 3.16205910485182 3.06259968006462 0.0994594247872045 1.867902854046 1.48204956124443 0.0614700832775623 0.0532465725247804 0.0671093783825229 0.841770925540977 NA NA NA 0.854155629427291 99.727107917785 a9738 loss_cnaBRCA17 17 Cyclopamine SMO 3 10 2.77258872223978 NA 4.60783596821188 4.72198162026412 -0.114145652052234 0.513145228816769 0.906673760996825 0.134478210177475 0.222443171332677 0.125894954682199 0.841859756573254 NA NA NA 0.790778815012553 99.727107917785 a9739 gain_cnaBRCA63 309 Y-39983 ROCK 7 42 2.99573227355399 NA 5.01152228473678 4.92222403433801 0.0892982503987696 1.35966055562407 1.04584361107039 0.0818541540656085 0.0656768706199487 0.08538394216261 0.841953945191093 NA NA NA 0.872867924303311 99.727107917785 a9740 loss_cnaBRCA20 140 Vinorelbine Microtubules 3 44 -2.74887219562247 NA -3.7855092172004 -3.58715629062847 -0.198352926571926 0.354023002159447 1.69469340726884 0.119613223407985 0.560282595656287 0.117043546473454 0.842027845401451 NA NA NA 0.555844656264482 99.727107917785 a9741 TP53_mut 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 37 11 0.246860077931526 2.32630161961136 -0.291173228693778 -0.176752760342934 -0.114420468350844 1.63172518650801 1.78047669303862 0.0687130284248316 0.0701223890499052 0.0642639517822444 0.842295644215757 NA NA NA 0.851289842091718 99.727107917785 a9742 ARID1A_mut 211 TL-2-105 CRAF 5 44 2.32630161961136 1.63315443905142 3.814645931939 3.91811144158567 -0.103465509646664 0.878902615965989 1.11396532208995 0.0944093315944308 0.11772124438718 0.0928803685311755 0.842308260255542 NA NA NA 0.817384564373986 99.727107917785 a9743 NF1_mut 184 BMS-754807 IGF1R 5 43 0.940007258491471 NA 1.76993972732983 1.61023281832523 0.159706909004597 0.714133844270022 1.75549146600057 0.0944677502790982 0.223637221910197 0.0909756111594479 0.842415058936605 NA NA NA 0.70879878093923 99.727107917785 a9744 loss_cnaBRCA20 1199 Tamoxifen ER 3 44 1.6094379124341 NA 3.97635297288936 3.86186230747997 0.11449066540939 0.713080905794096 0.97003167077078 0.119252036882674 0.16055774944905 0.118027760184796 0.842498398441128 NA NA NA 0.813094503128991 99.727107917785 a9745 PTEN_mut 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 8 40 2.07944154167984 NA 3.28969344309069 3.19922545236138 0.0904679907293069 1.09406602091774 1.18238143008882 0.0773645632553031 0.0826896997069879 0.0765133724423523 0.842553071188928 NA NA NA 0.837229609491609 99.727107917785 a9746 loss_cnaBRCA36_(FAT1,IRF2) 286 KIN001-236 TIE2 9 40 2.32630161961136 NA 4.58655319912562 4.52965291911029 0.056900280015328 0.608751475127767 0.801845970112668 0.073667295866243 0.0934704593584525 0.0709616087580173 0.842594654196739 NA NA NA 0.815247336435726 99.727107917785 a9747 loss_cnaBRCA28_(GPS2) 1219 PFI-1 BRD2, BRD3, BRD4 4 43 2.30258509299405 NA 3.26832907153072 3.16356496856779 0.104764102962932 0.962833101925751 1.00817733789373 0.10422027880306 0.108808164938861 0.103914360128153 0.842868721846991 NA NA NA 0.846846022310159 99.727107917785 a9748 gain_cnaBRCA47_(EGFR) 1529 MLN4924 NEDD8-activating enzyme 6 31 0 NA 0.497204256014527 0.344443210995253 0.152761045019274 1.42947406288308 1.75845779694345 0.0890564891970235 0.106865209370202 0.0868721701964089 0.842891256146063 NA NA NA 0.823538285827091 99.727107917785 a9749 POLR2B_mut 294 MPS-1-IN-1 MPS1 3 46 2.99573227355399 NA 4.88813363818712 4.74793405500421 0.140199583182905 0.755963581848964 1.19595828924797 0.118754796274894 0.185458118022034 0.11722782010321 0.842893031069269 NA NA NA 0.787230826912512 99.727107917785 a9750 loss_cnaBRCA57 1004 Vinblastine Microtubules 5 40 -2.30258509299405 NA -3.34685380216406 -3.46914867483606 0.122294872671995 0.864979252150175 1.32925838116778 0.0945734311729513 0.141384746938141 0.0920023333345896 0.842906667636055 NA NA NA 0.78960844713104 99.727107917785 a9751 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 150 Bicalutamide ANDR (androgen receptor) 6 42 0.0237165266173161 NA 2.81035792934058 2.75576343118301 0.0545944981575737 0.63068733070001 0.627573796465438 0.0869459632085509 0.0865634927167133 0.0869929536017208 0.842970029973195 NA NA NA 0.848746540737385 99.727107917785 a9752 gain_cnaBRCA16 185 OSI-906 IGF1R 16 32 0.940007258491471 NA 2.93966154425503 2.8704040967675 0.0692574474875283 1.27295929520038 1.06337069164916 0.0609675836905015 0.0544066473677986 0.0651301075263963 0.843046966010549 NA NA NA 0.852830744107314 99.727107917785 a9753 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 167 OSU-03012 PDPK1 (PDK1) 15 33 2.77258872223978 NA 2.29874203496229 2.22490493332159 0.0738371016407036 1.16650441539741 1.20374173036871 0.061916257483005 0.063297747240458 0.0613396543277495 0.843270247080372 NA NA NA 0.841968018391044 99.727107917785 a9754 loss_cnaBRCA34 1001 AICAR AAPK1 (AMPK) agonist 5 40 7.60090245954208 NA 7.62193930608557 7.75305129440149 -0.131111988315917 1.70918419573176 1.35451189126695 0.0942354149412494 0.0767102742017712 0.0967964837822725 0.843460609877473 NA NA NA 0.875749424792321 99.727107917785 a9755 loss_cnaBRCA24 201 Epothilone B Microtubules 3 45 -3.44201937618241 NA -4.43677432812583 -4.22235683121622 -0.214417496909609 1.0854857141835 1.84383958667831 0.11797649340413 0.197531385358574 0.116288585221171 0.844032148477757 NA NA NA 0.775633485094277 99.727107917785 a9756 gain_cnaBRCA14_(RAD21) 305 TPCA-1 IKK 21 28 2.99573227355399 NA 4.2236912185493 4.1443027259905 0.0793884925588015 1.38264259025779 1.39657055073171 0.0570868841937104 0.0574179423649897 0.056845314772825 0.84408975900497 NA NA NA 0.843933868706431 99.727107917785 a9757 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 288 KIN001-055 JAK3, MNK1 9 40 2.32630161961136 NA 4.39024585766353 4.3274782443166 0.0627676133469279 0.549131328757754 0.912157490641669 0.0728804422167407 0.114303464508064 0.068812254452653 0.844253603254214 NA NA NA 0.790495320613835 99.727107917785 a9758 gain_cnaBRCA12_(TERT) 150 Bicalutamide ANDR (androgen receptor) 9 39 0.0237165266173161 NA 2.79985626498608 2.75398731540654 0.0458689495795435 0.435695660547848 0.661303602374528 0.0730493227671592 0.105277499256861 0.0693614089124009 0.844277402276253 NA NA NA 0.801508879329792 99.727107917785 a9759 ARID1A_mut 288 KIN001-055 JAK3, MNK1 5 44 2.32630161961136 NA 4.41108117388124 4.33081674141431 0.0802644324669277 0.90492136820648 0.857064643385647 0.0931962411333001 0.0886976872101151 0.0936503834178255 0.844307565787488 NA NA NA 0.857788586273778 99.727107917785 a9760 loss_cnaBRCA18 1004 Vinblastine Microtubules 14 31 -2.30258509299405 NA -3.51223032074423 -3.42996746818849 -0.0822628525557372 1.53261033618035 1.17428730434457 0.0636152181348723 0.0536749952768537 0.0700534292173518 0.844320070060943 NA NA NA 0.86006736651747 99.727107917785 a9761 gain_cnaBRCA31 193 GW-2580 CSF1R (cFMS) 16 32 2.99573227355399 NA 5.4936519010048 5.44825735078943 0.0453945502153736 0.826223167441783 0.711924977238558 0.0604366480845351 0.0549422383735956 0.0637631094099995 0.844395679025608 NA NA NA 0.852562678843545 99.727107917785 a9762 BRCA2_mut 269 NSC-207895 MDM4 6 43 2.99573227355399 NA 4.69413488899928 4.5913574009595 0.102777488039772 1.27435560446193 1.18662725683913 0.0859152531521362 0.0806505559985884 0.0866131191976365 0.844565466995978 NA NA NA 0.857873580431954 99.727107917785 a9763 loss_cnaBRCA28_(GPS2) 1502 Bicalutamide ANDR (androgen receptor) 4 41 2.30258509299405 NA 4.50298524901795 4.56369999967392 -0.0607147506559764 0.408436590709797 0.599272915270514 0.103261274006726 0.148651594976993 0.101314024226457 0.844654511806558 NA NA NA 0.799219500934527 99.727107917785 a9764 BRCA1_mut 204 Tipifarnib Farnesyl-transferase (FNTA) 4 44 2.77258872223978 NA 1.7637215344251 1.60690879959916 0.156812734825935 0.17907141639222 1.57648838323549 0.102834741573552 0.87569941638518 0.0994696418276817 0.844762666655718 NA NA NA 0.540159886765357 99.727107917785 a9765 gain_cnaBRCA47_(EGFR) 163 JQ1 BRD4 7 40 0.940007258491471 NA 0.416785008226457 0.298264798446924 0.118520209779533 1.85824014121307 1.39943563720604 0.0806856650532243 0.0637808898596728 0.084691433195283 0.844763934101172 NA NA NA 0.876532703003555 99.727107917785 a9766 loss_cnaBRCA29_(MAP2K4) 140 Vinorelbine Microtubules 7 40 -2.74887219562247 NA -3.48596313520942 -3.6197415623197 0.133778427110277 1.68593431508938 1.65402139146204 0.0806714494022675 0.0793497266844498 0.080880711580173 0.844790925200713 NA NA NA 0.850754939197448 99.727107917785 a9767 loss_cnaBRCA57 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 5 41 0 NA 0.825585691652655 0.632194347100559 0.193391344552096 1.38680243302044 2.13168533723157 0.0931985131807788 0.139451258483079 0.0907222755508816 0.844931905194504 NA NA NA 0.791935709096914 99.727107917785 a9768 loss_cnaBRCA34 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 37 1.38629436111989 0.693147180559945 3.52040633716936 3.42167620242819 0.0987301347411758 0.442492742984624 1.09990902636527 0.0937781148316355 0.22312260778615 0.0897620915680971 0.844967348091451 NA NA NA 0.71880346622475 99.727107917785 a9769 loss_cnaBRCA34 295 NVP-BHG712 EPHB4 5 44 2.32630161961136 NA 3.98976513632258 3.87499724276041 0.114767893562164 0.730244905441375 1.27455501295982 0.0927352726416106 0.15716356623234 0.0900454608825755 0.845067564486223 NA NA NA 0.770573920836851 99.727107917785 a9770 gain_cnaBRCA62 257 NPK76-II-72-1 PLK3 10 39 2.32630161961136 NA 3.3905176680839 3.50163789424399 -0.111120226160089 2.28218097742775 1.38430633223623 0.0696313122754927 0.0486903656016502 0.0802714136115978 0.845109601158709 NA NA NA 0.885707846648349 99.727107917785 a9771 MACF1_mut 1023 GW 441756 NTRK1 3 42 0.693147180559945 NA 2.5030273189346 2.34901961032044 0.154007708614159 1.34467809615227 1.31001503863564 0.117415462960803 0.114531283773302 0.117561786752125 0.845165107310794 NA NA NA 0.863529740120687 99.727107917785 a9772 CDH1_mut 1019 Bosutinib SRC, ABL, TEC 4 41 0.693147180559945 NA 2.75084765169538 2.65398886761384 0.0968587840815376 0.238483489078762 0.973723702198495 0.102904121731172 0.4061446117536 0.0994725545479151 0.845184765205626 NA NA NA 0.622544893781164 99.727107917785 a9773 loss_cnaBRCA36_(FAT1,IRF2) 308 XL-880 MET 9 40 1.63315443905142 NA 1.75222057570227 1.86921864611915 -0.116998070416874 1.72155836369965 1.59297759622884 0.0724183248451177 0.0679605599693083 0.0734461493330797 0.845228233275169 NA NA NA 0.855214744628629 99.727107917785 a9774 gain_cnaBRCA27_(CLTC,PPM1D) 258 STF-62247 stimulates autophagy 9 40 2.32630161961136 NA 4.68805490817904 4.6179702047528 0.0700847034262395 0.774082995667228 1.00322805611592 0.072396866035118 0.0905390039808707 0.0698591940277049 0.845273496995855 NA NA NA 0.820189759107156 99.727107917785 a9775 loss_cnaBRCA28_(GPS2) 312 AV-951 VEGFR 4 44 -2.05572501506252 NA 0.692988138552817 0.626756549313581 0.0662315892392362 0.642459309272579 0.646486701978994 0.102490012933887 0.103090714514241 0.102448494356483 0.845276263712867 NA NA NA 0.854291176596245 99.727107917785 a9776 POLR2B_mut 1054 PD-0332991 CDK4, CDK6 3 39 1.38629436111989 0.693147180559945 3.04403214019876 2.87051032278626 0.173521817412505 2.35542414498007 1.41642905519776 0.117433370862888 0.0736690322982034 0.122506536261556 0.845601208770287 NA NA NA 0.910806063386285 99.727107917785 a9777 loss_cnaBRCA42 303 PIK-93 PI4K, PI3K 3 46 2.99573227355399 NA 2.63472615049073 2.80175335504869 -0.167027204557953 1.01549446120166 1.44763470250538 0.116646849119316 0.164478695787572 0.115379386988226 0.845645245622582 NA NA NA 0.808990649308441 99.727107917785 a9778 NF1_mut 193 GW-2580 CSF1R (cFMS) 4 44 2.99573227355399 NA 5.39301027379276 5.4697869215038 -0.0767766477110401 0.453595777036677 0.767580652800722 0.102216905652383 0.169262263005663 0.100024209092426 0.845683203283497 NA NA NA 0.775771034189925 99.727107917785 a9779 NF1_mut 1017 Olaparib PARP1, PARP2 4 41 1.6094379124341 NA 4.15778509313779 4.06593351290852 0.0918515802292657 0.777956161710814 0.904498422885346 0.102484346374994 0.118067809922957 0.101549740613432 0.845808086048059 NA NA NA 0.835655865471572 99.727107917785 a9780 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 156 AZD6482 PI3Kbeta 14 33 1.63315443905142 NA 2.11779458149967 2.02595262274435 0.0918419587553219 1.15577453779344 1.58322256715272 0.0623698321070624 0.0794635595024121 0.0580095058400357 0.845846647718938 NA NA NA 0.825779287692947 99.727107917785 a9781 loss_cnaBRCA20 136 Mitomycin C DNA crosslinker 3 45 2.77258872223978 NA -0.296906537417711 -0.123465202270125 -0.173441335147587 0.692494947914308 1.51550323714794 0.116465464443811 0.25045862886071 0.114444714399944 0.84600379116723 NA NA NA 0.727639437861012 99.727107917785 a9782 gain_cnaBRCA63 312 AV-951 VEGFR 7 41 -2.05572501506252 NA 0.676341202929515 0.624752495207371 0.0515887077221435 0.968003041472471 0.582835554130263 0.0798305430931789 0.0532939520971646 0.0885133162459981 0.846092673559373 NA NA NA 0.895148548928922 99.727107917785 a9783 loss_cnaBRCA20 154 CHIR-99021 GSK3B 3 44 0.940007258491471 NA 3.37490965327377 3.26865462330051 0.106255029973255 0.773687942244816 0.918578738620039 0.116427569738499 0.137335770885819 0.11567329560978 0.846180100006455 NA NA NA 0.838178846407574 99.727107917785 a9784 NF1_mut 134 Etoposide TOP2 4 43 2.77258872223978 NA 2.27417781459916 2.49597833713274 -0.221800522533576 1.01120395167364 2.23494339771428 0.101982449986245 0.219343014004718 0.0992421207447206 0.846198675127029 NA NA NA 0.728022640690089 99.727107917785 a9785 gain_cnaBRCA63 303 PIK-93 PI4K, PI3K 7 42 2.99573227355399 NA 2.88916456320528 2.77525430574464 0.113910257460643 0.932090164900409 1.49106691893193 0.0795512517290031 0.122209483320548 0.0763951342587885 0.846342466522197 NA NA NA 0.791249117342656 99.727107917785 a9786 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1054 PD-0332991 CDK4, CDK6 4 38 1.38629436111989 0.693147180559945 3.01996448281044 2.86847739678996 0.151487086020478 0.986243251550616 1.51047829354448 0.102520566400816 0.15360012429216 0.100290806341215 0.846354385437057 NA NA NA 0.795054783747331 99.727107917785 a9787 ARID1A_mut 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 39 1.6094379124341 NA 2.71722572930543 2.55196864572295 0.165257083582476 1.41366418634169 1.63121097947172 0.102244945056903 0.116899816221653 0.101309447804229 0.846553140637285 NA NA NA 0.837492412090327 99.727107917785 a9788 loss_cnaBRCA17 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 10 35 -0.669430653942629 NA -3.61907221933344 -3.44822556762156 -0.170846651711889 1.63883966789755 2.62269855022073 0.069742071572145 0.104248545515783 0.0651415511315664 0.84669937629243 NA NA NA 0.804355715311703 99.727107917785 a9789 gain_cnaBRCA48 1502 Bicalutamide ANDR (androgen receptor) 5 40 2.30258509299405 NA 4.51011935822686 4.56432610478921 -0.054206746562353 0.360671491634193 0.606495222532795 0.0921915522407717 0.1502939595163 0.0893770380185013 0.846811797810581 NA NA NA 0.780782648614836 99.727107917785 a9790 loss_cnaBRCA24 1114 Cetuximab EGFR 3 42 4.18661983833127 NA 6.37842876372921 6.27573907594764 0.102689687781565 1.15739263137149 0.868960705980577 0.11610382226115 0.0887250229508371 0.118175295010244 0.84687249133693 NA NA NA 0.893119904299924 99.727107917785 a9791 gain_cnaBRCA62 308 XL-880 MET 10 39 1.63315443905142 NA 1.75932612492862 1.87039666094359 -0.111070536014972 1.83272129846871 1.55975880212629 0.0687486907492792 0.0606041606586743 0.0712100716236117 0.847047773201965 NA NA NA 0.863102242456566 99.727107917785 a9792 loss_cnaBRCA36_(FAT1,IRF2) 1175 AG-014699 PARP1, PARP2 9 34 1.6094379124341 NA 3.92105478390989 3.84582484801732 0.0752299358925717 0.931553410085579 1.05820875267924 0.0727060450379881 0.0807575122135621 0.0710917724901627 0.847170275727517 NA NA NA 0.837329183485987 99.727107917785 a9793 gain_cnaBRCA31 271 VNLG/124 HDAC, RAR 16 33 1.63315443905142 NA 4.18399408771757 4.13565635674007 0.0483377309775017 0.914359137855314 0.770105572769132 0.0590269582443367 0.0528651478136708 0.0627676680791826 0.847196994527688 NA NA NA 0.856696530969102 99.727107917785 a9794 loss_cnaBRCA29_(MAP2K4) 202 GSK-1904529A IGF1R 7 41 0.0237165266173161 NA 2.13289604156013 2.19936829522942 -0.0664722536692941 0.486656277059262 0.879579626859078 0.0792437986154029 0.136589738595316 0.0755727527553841 0.847209435267461 NA NA NA 0.776432457377313 99.727107917785 a9795 gain_cnaBRCA61_(NOTCH2) 268 YM155 BIRC5 (Survivin) 3 46 1.63315443905142 NA -3.76999086508473 -3.58420325003499 -0.185787615049745 2.21434606028244 1.5772453776601 0.115431764396373 0.0839017976377403 0.117792461262665 0.847232591752054 NA NA NA 0.898676306580695 99.727107917785 a9796 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 301 PHA-793887 CDK-pan 6 42 2.32630161961136 NA 3.04454862018416 2.90480151842695 0.139747101757215 2.13289850051423 1.58517371259212 0.084514854971941 0.0655198087126618 0.0881588564376941 0.847304200129533 NA NA NA 0.882429699159866 99.727107917785 a9797 ASH1L_mut 1061 SB590885 BRAF 3 39 1.6094379124341 NA 3.89379180164982 4.02099784216596 -0.127206040516138 0.140181745103069 1.12492178096705 0.115970145780054 0.907436559750412 0.113079898236821 0.847500383434371 NA NA NA 0.524224618197569 99.727107917785 a9798 loss_cnaBRCA17 288 KIN001-055 JAK3, MNK1 11 38 2.32630161961136 NA 4.29478666683017 4.35180760938168 -0.0570209425515102 1.06424573325547 0.797574042782395 0.0662067463194448 0.0535787372875684 0.0714929768182883 0.847501335215475 NA NA NA 0.871552001182357 99.727107917785 a9799 loss_cnaBRCA17 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 6 37 -1.38629436111989 0.693147180559945 -2.29087115614854 -2.20910141949569 -0.081769736652844 0.647901894569032 0.995759626561392 0.0851670896690221 0.126206972596114 0.0821179474158994 0.847511386593318 NA NA NA 0.798337546840053 99.727107917785 a9800 gain_cnaBRCA48 1072 BMS-708163 g-secretase 5 41 1.6094379124341 NA 3.60569039167081 3.69383018077044 -0.0881397890996283 0.620882102975405 0.989766085410508 0.0916124951433073 0.141958978487611 0.089051130765985 0.847537046742678 NA NA NA 0.789755606747975 99.727107917785 a9801 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 205 BMS-708163 g-secretase 14 34 2.32630161961136 0.940007258491471 4.92622633768576 4.88430141523945 0.041924922446305 0.792607159917365 0.635985846011381 0.0613032362775011 0.0528949580151105 0.0659211564364826 0.847770894183429 NA NA NA 0.862073461274729 99.727107917785 a9802 gain_cnaBRCA19 262 VX-11e ERK 4 45 1.63315443905142 NA 3.9007403873707 3.76579608302413 0.134944304346577 1.25244540477241 1.34575184545582 0.100705437551778 0.107744660032585 0.100274285190276 0.847778866348608 NA NA NA 0.84834715642355 99.727107917785 a9803 BRCA2_mut 1061 SB590885 BRAF 5 37 1.6094379124341 NA 4.10085980901962 3.99989168119794 0.100968127821686 0.588129238863162 1.13948029591973 0.0920496190475792 0.171676769576794 0.0886089282835643 0.847788299503001 NA NA NA 0.761777516520415 99.727107917785 a9804 loss_cnaBRCA34 186 Bexarotene Retinioic acid X family agonist 5 42 2.07944154167984 NA 3.51074823319881 3.61555513235167 -0.104806899152864 0.975837997719836 1.16396908218261 0.0912558680646711 0.107401945197623 0.090042683055065 0.847908975351966 NA NA NA 0.832326076173276 99.727107917785 a9805 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1036 PLX4720 BRAF 4 39 2.30258509299405 NA 4.70799156026626 4.5851925119727 0.122799048293563 0.435556796036072 1.25294340066561 0.101321552807684 0.281935787504951 0.0980084561108893 0.847921341404638 NA NA NA 0.687375666231077 99.727107917785 a9806 ASH1L_mut 1021 Axitinib PDGFR, KIT, VEGFR 3 42 0.693147180559945 NA 2.3354731716985 2.47141462411747 -0.135941452418965 1.16060498064336 1.18028452981613 0.115265527434809 0.117129819952701 0.115176848450384 0.847964103803432 NA NA NA 0.860713883734385 99.727107917785 a9807 gain_cnaBRCA13_(FGFR1,WHSC1L1) 298 OSI-930 KIT, VEGFR, PDGFR 11 37 2.32630161961136 NA 3.95828384082694 3.90001372919272 0.0582701116342235 0.562786183683229 0.949661445871926 0.0662051366776567 0.103538632119337 0.0613588262296182 0.847977718287499 NA NA NA 0.802310946775098 99.727107917785 a9808 loss_cnaBRCA60 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 44 2.99573227355399 NA 4.00249976824308 3.83710526383074 0.165394504412343 1.9793076702093 1.40783696269448 0.115011757546303 0.0835617963299533 0.117481291367569 0.848026927954548 NA NA NA 0.899120970139118 99.727107917785 a9809 TP53_mut 223 ZSTK474 PI3K 38 11 1.63315443905142 2.32630161961136 0.890757084550456 0.986890081125155 -0.0961329965746993 1.38313853738429 1.70607603765769 0.0659415332132179 0.0695035196955036 0.0563474279298139 0.848104532316301 NA NA NA 0.866436261483294 99.727107917785 a9810 loss_cnaBRCA36_(FAT1,IRF2) 309 Y-39983 ROCK 9 40 2.99573227355399 NA 4.99824949354644 4.9207454998359 0.0775039937105442 0.948598325566751 1.11794691482762 0.0710407345596352 0.0817037007357551 0.0693270786676799 0.848135089493895 NA NA NA 0.833781220133612 99.727107917785 a9811 loss_cnaBRCA20 1059 AZD8055 MTORC1/2 3 40 0.693147180559945 NA 0.0214804832777892 0.138602002427139 -0.11712151914935 2.05622846895785 0.931666290486263 0.115296516633669 0.0569593899303954 0.125711878110585 0.848217477148212 NA NA NA 0.93069665909057 99.727107917785 a9812 gain_cnaBRCA19 1527 GDC0941 (rescreen) PI3K 4 41 1.38629436111989 NA 0.873629640953569 0.991097421891424 -0.117467780937855 1.46565198518783 1.13925836204307 0.100830612314468 0.080147116863353 0.103108991648914 0.848264670096061 NA NA NA 0.885104177822208 99.727107917785 a9813 ASH1L_mut 1133 JNJ-26854165 MDM2 3 40 2.30258509299405 NA 2.87455154463934 2.97588559856325 -0.101334053923909 0.792148141456501 0.883605361730523 0.115235520687137 0.127923110111183 0.114682479659752 0.848296764797279 NA NA NA 0.848920284505638 99.727107917785 a9814 gain_cnaBRCA15 287 KIN001-244 PDPK1 (PDK1) 22 27 2.99573227355399 NA 3.44924431159102 3.50162300725924 -0.0523786956682191 1.16727990560549 0.727223208016558 0.0551705437345702 0.0448724384071783 0.0720256106939679 0.848500052304759 NA NA NA 0.855544642110662 99.727107917785 a9815 loss_cnaBRCA28_(GPS2) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 42 2.30258509299405 NA 3.3174279431606 3.16682690929414 0.150601033866456 0.208918775658031 1.34313603414318 0.114760946839109 0.720859259260487 0.112126419095389 0.84862130531832 NA NA NA 0.536466414404147 99.727107917785 a9816 BRCA2_mut 231 FMK RSK 6 43 2.99573227355399 2.32630161961136 5.54536879412821 5.59534982340089 -0.0499810292726757 0.411230731423372 0.616021822962149 0.0836389411862358 0.121540112286061 0.0811351601674454 0.848631626364721 NA NA NA 0.801183079573979 99.727107917785 a9817 gain_cnaBRCA13_(FGFR1,WHSC1L1) 305 TPCA-1 IKK 11 38 2.99573227355399 NA 4.10746992726447 4.19883743993053 -0.0913675126660571 1.60722848979889 1.32611650358984 0.0656991930373243 0.0568478677711156 0.0688985563626741 0.848655787842518 NA NA NA 0.865616391906946 99.727107917785 a9818 PIK3CA_mut 194 AUY922 HSP90 16 31 -1.36257783450257 NA -2.46154692909324 -2.35875360163595 -0.102793327457296 2.25607158986165 1.41342592779007 0.0590681559301204 0.0455629723450397 0.0727263632541511 0.848694073896608 NA NA NA 0.869575051440991 99.727107917785 a9819 gain_cnaBRCA47_(EGFR) 306 TG101348 JAK2 7 41 2.32630161961136 NA 3.13832942549666 3.23966738392842 -0.101337958431764 1.05662267183366 1.32410876140987 0.0784129359580848 0.0959074238449783 0.0765329566461464 0.848791373400316 NA NA NA 0.826471887195436 99.727107917785 a9820 MACF1_mut 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 3 40 -1.38629436111989 0.693147180559945 -2.11796250062031 -2.22820229890927 0.110239798288959 0.53205280360732 0.977026748983271 0.114819100728045 0.207197100628985 0.112831914176023 0.84883810488559 NA NA NA 0.768726938084179 99.727107917785 a9821 PTEN_mut 155 AP-24534 ABL 8 39 -0.669430653942629 NA 1.51590863279976 1.43088819745024 0.085020435349523 0.866070018201428 1.18707339620481 0.0743786621027767 0.0981680852156565 0.0716218859097856 0.848889573406281 NA NA NA 0.817162636201683 99.727107917785 a9822 MLL3_mut 1072 BMS-708163 g-secretase 3 43 1.6094379124341 NA 3.58133052084778 3.69143018156741 -0.110099660719632 0.873393717557961 0.966121951244644 0.114436704544382 0.126059597757899 0.113960417292861 0.848907542466629 NA NA NA 0.850761816467554 99.727107917785 a9823 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 290 KIN001-260 IKK 6 43 2.99573227355399 NA 4.96724296816583 5.0547941931761 -0.0875512250102677 1.01822754251708 1.05287861287625 0.0834419808121038 0.0859839489254427 0.0831541489584403 0.848983652421642 NA NA NA 0.850166469867953 99.727107917785 a9824 gain_cnaBRCA19 1218 JQ1 BRD2, BRD3, BRD4 4 42 0 NA 2.39328933475493 2.46414306603135 -0.0708537312764257 0.476975671220758 0.721311140873363 0.100169535754551 0.148547893638023 0.0982290820999049 0.849068901332864 NA NA NA 0.799831492066839 99.727107917785 a9825 CDH1_mut 201 Epothilone B Microtubules 4 44 -3.44201937618241 NA -4.40225712463055 -4.22062163387693 -0.181635490753616 1.78464633495415 1.81977995754608 0.0999364829143987 0.101776742649844 0.0998117876836854 0.849082763942547 NA NA NA 0.856233835690321 99.727107917785 a9826 gain_cnaBRCA61_(NOTCH2) 238 CAL-101 PI3Kdelta 3 46 2.99573227355399 2.32630161961136 4.61706666808458 4.7256097119112 -0.108543043826621 1.22796741675298 0.937975699162258 0.114001821363077 0.0883924462048296 0.115720528712594 0.849101440859665 NA NA NA 0.893452934572131 99.727107917785 a9827 loss_cnaBRCA34 282 EKB-569 EGFR 5 42 0.916290731874155 2.99573227355399 1.75048905242339 1.55754107106516 0.19294798135823 0.720136890052277 2.22158356828225 0.0905268052601265 0.267932366781298 0.0868515522499201 0.849108925085925 NA NA NA 0.68702641834455 99.727107917785 a9828 loss_cnaBRCA36_(FAT1,IRF2) 329 QL-XI-92 DDR1 9 39 2.32630161961136 NA 4.1985868203844 4.26596931614841 -0.0673824957640008 0.675062732656944 1.00226915311683 0.0706712335339933 0.0998166429641192 0.067229940734439 0.84928311343522 NA NA NA 0.81026301646541 99.727107917785 a9829 gain_cnaBRCA8_(CHD4,WNK1) 1047 Nutlin-3a MDM2 3 40 2.07944154167984 1.38629436111989 4.09920277363831 4.21502520264009 -0.115822429001788 0.81484171836368 1.02238729007511 0.114307862134964 0.142141015109506 0.113286256711269 0.84950280893778 NA NA NA 0.833621959792066 99.727107917785 a9830 gain_cnaBRCA47_(EGFR) 1021 Axitinib PDGFR, KIT, VEGFR 7 38 0.693147180559945 NA 2.54054556419412 2.44794775733343 0.092597806860693 1.13016681282575 1.18717630443566 0.0785135089730319 0.0819328667324525 0.0779983617553 0.849511669684375 NA NA NA 0.84792018756873 99.727107917785 a9831 gain_cnaBRCA27_(CLTC,PPM1D) 262 VX-11e ERK 9 40 1.63315443905142 NA 3.85373154144315 3.7595050353145 0.0942265061286505 0.857902199234 1.41879025097791 0.0703181070380101 0.10983362230891 0.0664132743114809 0.849660763048768 NA NA NA 0.798177282617814 99.727107917785 a9832 loss_cnaBRCA34 1013 Nilotinib ABL 4 36 0.693147180559945 NA 3.29032442973569 3.19319437714666 0.0971300525890273 0.451210913996594 0.997852005477853 0.100547790350144 0.215265299610551 0.0973391365210651 0.849716691295608 NA NA NA 0.739157694342414 99.727107917785 a9833 gain_cnaBRCA10_(MDM2,NUP107) 1039 SL 0101-1 RSK, AURKB, PIM3 3 40 2.30258509299405 NA 4.75203578591044 4.64108780214923 0.110947983761215 0.935807048522608 0.973880562884281 0.114137215319642 0.118558610919177 0.113923604176499 0.849724705857493 NA NA NA 0.859321342447347 99.727107917785 a9834 gain_cnaBRCA12_(TERT) 1020 Lenalidomide TNFA 10 35 1.6094379124341 NA 4.21672166507078 4.26558512311653 -0.0488634580457514 0.758429481231191 0.704028616398155 0.0682682163629954 0.0644271606721159 0.069405499872632 0.849898801486578 NA NA NA 0.857848360289511 99.727107917785 a9835 CDH1_mut 263 FR-180204 ERK 4 45 2.99573227355399 NA 5.42518796464242 5.35190239378993 0.0732855708524927 0.660921337519582 0.743282940613111 0.0992625395022497 0.110883953493666 0.0985971382473029 0.849932952719661 NA NA NA 0.844500818769108 99.727107917785 a9836 gain_cnaBRCA15 1241 CHIR-99021 GSK3B 21 25 2.30258509299405 NA 4.20133507820154 4.25681478448668 -0.0554797062851424 0.916883116807282 1.03837342165772 0.0563240090940928 0.060509028106364 0.0534294360082629 0.849964522515765 NA NA NA 0.848327250716201 99.727107917785 a9837 gain_cnaBRCA14_(RAD21) 292 Masitinib KIT 21 27 2.99573227355399 NA 3.97616606996397 4.03689729027762 -0.060731220313647 1.29999060292641 0.911320903578233 0.0553432686841644 0.0467166610104218 0.0666408726884135 0.849980699117147 NA NA NA 0.856580427806022 99.727107917785 a9838 loss_cnaBRCA33 255 CP724714 ERBB2 6 42 2.32630161961136 NA 3.92510893533865 3.78559664948829 0.139512285850357 0.648250678242547 1.76565376832664 0.0830143845506705 0.215213482272915 0.0790145204869795 0.849981624590418 NA NA NA 0.717521550738975 99.727107917785 a9839 gain_cnaBRCA48 156 AZD6482 PI3Kbeta 5 42 1.63315443905142 NA 2.17168876573863 2.03921706816347 0.132471697575164 1.53286065197529 1.46655767327597 0.0899593927582894 0.0864212264855626 0.0903283246128679 0.850043068139473 NA NA NA 0.861734186973434 99.727107917785 a9840 gain_cnaBRCA31 302 PI-103 PI3Ka, PRKDC (DNAPK) 16 32 2.32630161961136 NA 1.20090328363301 1.0921980972906 0.108705186342402 2.07451097183974 1.75831251712355 0.0582147596581124 0.0524003911370007 0.0618235866967689 0.850044914998643 NA NA NA 0.858710771500871 99.727107917785 a9841 gain_cnaBRCA19 164 JQ12 HDAC 4 43 1.63315443905142 NA 1.42752939443265 1.59186956915642 -0.164340174723769 2.19534033053708 1.60782714333263 0.0993891600197325 0.0748586323668384 0.102212588837835 0.850061115463701 NA NA NA 0.892291219393428 99.727107917785 a9842 loss_cnaBRCA24 151 QS11 ARFGAP 3 45 2.32630161961136 NA 3.9189229519989 3.74988502213937 0.16903792985953 1.85603338298699 1.47273254262131 0.113338163939766 0.0910748327099001 0.114778430548333 0.850087552090083 NA NA NA 0.890371662979724 99.727107917785 a9843 gain_cnaBRCA16 1114 Cetuximab EGFR 15 30 4.18661983833127 NA 6.31803099230924 6.264862086545 0.0531689057642453 0.635622084885319 0.982308286558307 0.0601131230097803 0.0836486129550363 0.054126496225062 0.850129746501326 NA NA NA 0.827990227003169 99.727107917785 a9844 loss_cnaBRCA17 41 S-Trityl-L-cysteine KIF11 3 9 1.63315443905142 NA 1.06043092543615 1.27871748833082 -0.218286562894667 0.930153354200682 1.83182610616988 0.129131853464862 0.234678036593492 0.119163364993786 0.85029045431872 NA NA NA 0.795675714305112 99.727107917785 a9845 gain_cnaBRCA14_(RAD21) 196 Phenformin AAPK1 (AMPK) agonist 21 27 8.29404964010203 NA 7.14539319500172 7.24605077553279 -0.100657580531068 2.16387594687787 1.5127072161699 0.0551667596248274 0.0465172602321776 0.0665413501403976 0.850453327001683 NA NA NA 0.857079287573462 99.727107917785 a9846 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 231 FMK RSK 9 40 2.99573227355399 2.32630161961136 5.62333399370985 5.58155623069047 0.0417777630193772 0.222880345751909 0.64820777927017 0.0699107952922263 0.18744480532115 0.0644511904291177 0.85052097129848 NA NA NA 0.743153173839342 99.727107917785 a9847 gain_cnaBRCA14_(RAD21) 261 TL-1-85 MAP3K7 (TAK1) 21 28 2.32630161961136 NA 4.06293403685085 3.9962107877616 0.0667232490892533 1.47860505952564 0.986640992065097 0.0546700558462499 0.0451258087204565 0.0676266743687566 0.850608433392626 NA NA NA 0.859000254416492 99.727107917785 a9848 gain_cnaBRCA9_(KRAS) 153 Midostaurin KIT 4 43 -0.669430653942629 NA 0.744935409851717 0.599835102196351 0.145100307655367 1.54185641495196 1.46070301974636 0.0989599396530557 0.0941075357265921 0.0993359400876449 0.850700756923941 NA NA NA 0.866433346597261 99.727107917785 a9849 gain_cnaBRCA62 83 JW-7-52-1 MTOR 4 8 0.182321556793955 NA -1.84198833889508 -2.10887881279277 0.266890473897686 0.934148169033466 2.62851005302326 0.118202698025956 0.285704648090066 0.10153679024005 0.850803998024324 NA NA NA 0.80292292379579 99.727107917785 a9850 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1194 SB-505124 TGFR1 (ALK5) 18 29 2.30258509299405 NA 4.35666378424171 4.40906927855746 -0.0524054943157513 0.952026843416147 0.907903153734497 0.0566656423283972 0.0550462360154733 0.0577214586161427 0.851063214653545 NA NA NA 0.852966872490282 99.727107917785 a9851 PIK3CA_mut 279 BIX02189 MAP2K5 (MEK5) 17 32 2.99573227355399 NA 5.06088476188848 5.00954391345665 0.051340848431833 0.897146178025315 0.911053749510174 0.0566461440999926 0.057226848521874 0.0563532595738026 0.851106589913143 NA NA NA 0.85073600141239 99.727107917785 a9852 gain_cnaBRCA13_(FGFR1,WHSC1L1) 208 SB-715992 KIF11 11 38 -2.05572501506252 NA -1.1537249387644 -1.26484448864148 0.111119549877084 2.15495683078842 1.58215782327007 0.0646014033999196 0.0515646291793367 0.0702329111816525 0.851153902599105 NA NA NA 0.876015421758527 99.727107917785 a9853 MLL3_mut 1262 UNC1215 LMBL3 3 43 0 NA 2.69446610281761 2.76191944056862 -0.0674533377510147 0.728894301060289 0.59153480442871 0.112711002890893 0.0925420018415474 0.114031054886381 0.851158275763092 NA NA NA 0.88874495973943 99.727107917785 a9854 loss_cnaBRCA29_(MAP2K4) 1038 NU-7441 PRKDC (DNAPK) 5 38 0.693147180559945 NA 2.81725955855938 2.90281310213521 -0.0855535435758363 0.824901220827993 0.965202800179103 0.0898270566239552 0.103713682821274 0.0886378940881243 0.85116487754666 NA NA NA 0.83857583738874 99.727107917785 a9855 gain_cnaBRCA14_(RAD21) 158 PF-562271 FAK 20 25 0.940007258491471 NA 2.29240640291581 2.36592524766406 -0.0735188447482513 1.4029428592138 1.21003802215752 0.0566046500712937 0.0524033065676321 0.0607574666266818 0.851229640746392 NA NA NA 0.853785756210115 99.727107917785 a9856 gain_cnaBRCA16 5 Sunitinib PDGFRA, PDGFRB, KDR, KIT, FLT3 3 9 2.07944154167984 NA 3.11674085953637 3.30162470181656 -0.184883842280188 1.73571109391217 1.35729151454911 0.128307098626422 0.106517635871919 0.136215278956935 0.851233708130484 NA NA NA 0.877615364173405 99.727107917785 a9857 gain_cnaBRCA27_(CLTC,PPM1D) 299 OSI-027 MTORC1/2 9 39 2.99573227355399 NA 1.15590536644742 1.29506130144191 -0.139155934994488 2.53023107575718 1.86825234826301 0.0696062518861109 0.0549973227061269 0.0744845497578887 0.851526874666736 NA NA NA 0.879489534999568 99.727107917785 a9858 BRCA2_mut 1008 Methotrexate Dihydrofolate reductase (DHFR) 5 40 -1.6094379124341 NA 0.769787441923701 0.671757903514132 0.0980295384095683 0.775562928643649 1.1258494896405 0.0892809806285061 0.126397916647471 0.0870716195295966 0.851589011064273 NA NA NA 0.809419514443594 99.727107917785 a9859 loss_cnaBRCA36_(FAT1,IRF2) 190 Bleomycin DNA damage 9 39 4.15888308335967 NA 1.92224906383838 2.11443379305812 -0.192184729219737 3.26952044788875 2.64439041744038 0.0695493383204664 0.0587807087561841 0.0726763824101894 0.851646818386545 NA NA NA 0.872546445878566 99.727107917785 a9860 gain_cnaBRCA27_(CLTC,PPM1D) 312 AV-951 VEGFR 9 39 -2.05572501506252 NA 0.668791758953009 0.623849099831583 0.0449426591214265 0.459805991857759 0.679005485574527 0.0695440984725508 0.0977426565057235 0.0661889485081246 0.851657861395133 NA NA NA 0.813813005474466 99.727107917785 a9861 loss_cnaBRCA28_(GPS2) 305 TPCA-1 IKK 4 45 2.99573227355399 NA 4.30362270112892 4.16718891361674 0.13643378751218 0.844216148708207 1.42034095534444 0.098103250252324 0.161610018620168 0.0960570678461456 0.851664481588355 NA NA NA 0.785007076081224 99.727107917785 a9862 gain_cnaBRCA12_(TERT) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 9 38 2.32630161961136 NA 1.32993192000795 1.43754257093612 -0.107610650928166 1.30595911674623 1.5907596737556 0.0696972459295235 0.0823997088027343 0.0676473339772998 0.851714474493503 NA NA NA 0.834620262084163 99.727107917785 a9863 gain_cnaBRCA13_(FGFR1,WHSC1L1) 303 PIK-93 PI4K, PI3K 11 38 2.99573227355399 NA 2.7200889354397 2.81220669720724 -0.0921177617675384 1.16056920582304 1.49687522888568 0.0643302511179897 0.0793729157256172 0.0615400402050299 0.851771171509557 NA NA NA 0.830893229818746 99.727107917785 a9864 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 292 Masitinib KIT 9 39 2.99573227355399 NA 3.94839987028318 4.02461834549206 -0.0762184752088881 0.736482977427929 1.15911141219974 0.0694558436166711 0.103489798875014 0.0657559527122953 0.851843863506767 NA NA NA 0.80713149530375 99.727107917785 a9865 ASH1L_mut 1024 CEP-701 FLT3, JAK2, NTRK1, RET 3 42 0.693147180559945 NA 0.474057016927537 0.63639120131486 -0.162334184387323 1.57730810854402 1.44010789837731 0.112203947356482 0.102918499884699 0.112723626174288 0.851953387995196 NA NA NA 0.876889704514292 99.727107917785 a9866 TP53_mut 17 Cyclopamine SMO 9 4 2.77258872223978 NA 4.66565520787511 4.76310680910022 -0.0974516012251083 0.92610299761209 0.596541788581964 0.114783190621564 0.105227605867147 0.163360896236222 0.851996979858213 NA NA NA 0.825479426800224 99.727107917785 a9867 POLR2B_mut 164 JQ12 HDAC 3 44 1.63315443905142 NA 1.4047149400141 1.58969009616851 -0.184975156154408 0.781661198554296 1.68311623638688 0.111867476249085 0.236643646245362 0.109900405067383 0.852131494033879 NA NA NA 0.741653022972743 99.727107917785 a9868 gain_cnaBRCA19 301 PHA-793887 CDK-pan 4 44 2.32630161961136 NA 2.77394762159588 2.93575375019666 -0.161806128600783 1.93020944798435 1.6325147454571 0.0978529521435978 0.0838282750971669 0.0991146506033414 0.852191344219066 NA NA NA 0.880126282030497 99.727107917785 a9869 gain_cnaBRCA14_(RAD21) 1050 ZM-447439 AURKB 17 22 1.38629436111989 0.693147180559945 2.93333070939407 2.8528371418684 0.0804935675256755 1.5305390939672 1.15166374388474 0.0605749911063223 0.0525916442402224 0.0698932895587717 0.852227349195799 NA NA NA 0.857744054747001 99.727107917785 a9870 loss_cnaBRCA34 279 BIX02189 MAP2K5 (MEK5) 5 44 2.99573227355399 NA 4.95543750266744 5.03552860612227 -0.0800911034548246 0.569808001782554 0.931493749999228 0.0883667701934061 0.140558053246484 0.0859813642924507 0.852277204284 NA NA NA 0.791356986375045 99.727107917785 a9871 gain_cnaBRCA47_(EGFR) 176 IPA-3 PAK1, PAK2, PAK3 7 40 3.46573590279973 NA 4.39760569625189 4.51420535691022 -0.116599660658328 1.78381008247864 1.47588834995899 0.0766824723280577 0.0653655127323365 0.0790030361453616 0.85237207582099 NA NA NA 0.874494405700112 99.727107917785 a9872 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1052 RO-3306 CDK1 8 35 1.6094379124341 NA 3.59793458116051 3.5091565102506 0.0887780709099024 1.0077670420261 1.24866522152978 0.0733137412057758 0.088093842334252 0.0710983771944394 0.85251967563845 NA NA NA 0.83372205134559 99.727107917785 a9873 PTEN_mut 256 JW-7-24-1 LCK 9 39 2.32630161961136 NA 1.77174979510016 1.85275820561033 -0.0810084105101707 0.597705320036836 1.26020785520228 0.0691078533432673 0.135532356488275 0.0642817850847056 0.852577355589066 NA NA NA 0.777323479168909 99.727107917785 a9874 loss_cnaBRCA24 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 3 46 1.63315443905142 NA 3.6818700101488 3.56979517350083 0.112074836647975 1.05816562760494 1.00468617653045 0.111293582842521 0.105914266844639 0.111552083890524 0.852643336339303 NA NA NA 0.87333392701362 99.727107917785 a9875 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1259 BMN-673 PARP1 8 38 2.30258509299405 NA 3.39960880804599 3.28573366838093 0.113875139665055 1.2720605812278 1.61870853196685 0.0725923991454623 0.0895202173116169 0.0703493787894527 0.852819460011395 NA NA NA 0.830497244789524 99.727107917785 a9876 ARID1A_mut 304 SB52334 ALK5 5 44 2.99573227355399 NA 4.2005651579354 4.31340613303495 -0.112840975099545 1.12165286668252 1.29629238235088 0.0879950656958893 0.100602404229833 0.0870490150492927 0.852891251511993 NA NA NA 0.84180122154088 99.727107917785 a9877 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 310 YM201636 FYV1 6 43 1.63315443905142 NA 2.34166571016299 2.42485377779522 -0.0831880676322316 1.14597273887108 1.00869981127286 0.0812242088642022 0.0725916636674813 0.0824705890717459 0.852949591603246 NA NA NA 0.871298061892532 99.727107917785 a9878 loss_cnaBRCA38 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 4 44 2.77258872223978 NA -0.310076226700115 -0.44802274470557 0.137946518005454 0.836887670701157 1.44988964171754 0.0972816230347771 0.164832776052108 0.0951427708953369 0.853044170891928 NA NA NA 0.782252537362884 99.727107917785 a9879 gain_cnaBRCA58_(CCND1) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 8 34 1.38629436111989 0.693147180559945 3.37105092047567 3.44810717093777 -0.0770562504621024 1.22865898268776 1.01164817221094 0.0731876306067506 0.0627157344290421 0.0761690205930952 0.853189677748055 NA NA NA 0.87265609394167 99.727107917785 a9880 gain_cnaBRCA10_(MDM2,NUP107) 275 I-BET BRD2, BRD3, BRD4 5 44 2.99573227355399 NA 4.14686953350573 4.02667645999383 0.120193073511901 1.33057543513837 1.37237748026435 0.0878046215687102 0.0903316492532432 0.0875801849275094 0.853205896482436 NA NA NA 0.856171969717454 99.727107917785 a9881 gain_cnaBRCA62 341 EX-527 SIRT1 10 39 2.99573227355399 NA 5.67634461971655 5.63288365393979 0.0434609657767586 0.710986722104166 0.64629696333453 0.0659322648988471 0.0611276757013631 0.0672461240611814 0.853238768613284 NA NA NA 0.863302574427431 99.727107917785 a9882 loss_cnaBRCA24 262 VX-11e ERK 3 46 1.63315443905142 NA 3.91624414007567 3.7677185405509 0.148525599524768 0.263911195089818 1.36835212765684 0.110837676504327 0.562786279203577 0.108543405255709 0.853239884766959 NA NA NA 0.56670449080974 99.727107917785 a9883 gain_cnaBRCA8_(CHD4,WNK1) 150 Bicalutamide ANDR (androgen receptor) 3 45 0.0237165266173161 NA 2.69729217156041 2.76694078157886 -0.0696486100184446 0.61684709763185 0.628447586422113 0.110914671634846 0.112910655307991 0.110826442050592 0.853255116133715 NA NA NA 0.865477985551735 99.727107917785 a9884 BRCA1_mut 1161 ZG-10 IRAK1 3 23 2.30258509299405 NA 1.83114741690413 1.99422753335359 -0.163080116449458 0.545492177629489 1.47536484106765 0.114739746590559 0.298959587574923 0.110535449883329 0.853295832954458 NA NA NA 0.721942826163132 99.727107917785 a9885 loss_cnaBRCA38 155 AP-24534 ABL 4 43 -0.669430653942629 NA 1.54688969868033 1.43591511554037 0.110974583139962 0.893496334035295 1.15887766988308 0.0970817937277739 0.124202617193479 0.095760394754313 0.853500834466903 NA NA NA 0.828643321116183 99.727107917785 a9886 gain_cnaBRCA61_(NOTCH2) 346 THZ-2-102-1 CDK7 3 45 0.916290731874155 2.99573227355399 -1.06947455901579 -1.35286984398967 0.28339528497388 4.59104930348667 2.43085496276863 0.110575119208853 0.0617277807839387 0.116582556061307 0.853699116032288 NA NA NA 0.924992516392768 99.727107917785 a9887 MACF1_mut 1003 Camptothecin TOP1 3 42 -2.30258509299405 NA -2.69487917836871 -2.51745303443373 -0.177426143934976 0.733202275467364 1.63127312884372 0.110841858820046 0.241987988678677 0.108765442645855 0.853729477244175 NA NA NA 0.738561666386287 99.727107917785 a9888 loss_cnaBRCA20 309 Y-39983 ROCK 3 46 2.99573227355399 NA 4.82184457946077 4.94235938471677 -0.120514805256004 0.511317664423464 1.10976928446197 0.110461575675201 0.235694586049341 0.10859446818663 0.853732073801555 NA NA NA 0.742063001152757 99.727107917785 a9889 gain_cnaBRCA47_(EGFR) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 7 40 2.99573227355399 NA 3.75472157635272 3.86392699697032 -0.109205420617596 1.66240287934622 1.40041943622281 0.0759367268966669 0.065691308631842 0.07798050911957 0.853790972010236 NA NA NA 0.874086953764351 99.727107917785 a9890 loss_cnaBRCA20 223 ZSTK474 PI3K 3 46 1.63315443905142 2.32630161961136 0.761488263123575 0.922175985128768 -0.160687722005193 1.21100234264382 1.46790621892667 0.110218870892053 0.132689852320504 0.109467294254457 0.85404972365272 NA NA NA 0.843516866061096 99.727107917785 a9891 gain_cnaBRCA31 157 JNK-9L JNK 16 31 1.63315443905142 NA 0.0159443352652571 0.0764378268896313 -0.0604934916243742 0.999733036195438 1.09404218871919 0.0568796210450669 0.0605096455095522 0.0552935638571622 0.854233974233317 NA NA NA 0.850260122864903 99.727107917785 a9892 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 299 OSI-027 MTORC1/2 6 42 2.99573227355399 NA 1.40996314462947 1.24882762348772 0.161135521141748 1.88621443432654 2.01256272286616 0.0805993534491937 0.0854279970555316 0.0800648443454572 0.854294723876873 NA NA NA 0.851844158010539 99.727107917785 a9893 gain_cnaBRCA10_(MDM2,NUP107) 308 XL-880 MET 5 44 1.63315443905142 NA 1.72132967012601 1.86209278807855 -0.140763117952536 1.85792620451751 1.59125283899608 0.0871240607218438 0.0757635677941746 0.0884605604482966 0.854330491414542 NA NA NA 0.877479977226199 99.727107917785 a9894 gain_cnaBRCA64_(SDHC) 176 IPA-3 PAK1, PAK2, PAK3 8 39 3.46573590279973 NA 4.58720351433699 4.47830323167887 0.108900282658121 1.71622170042016 1.48171159389469 0.0716181488815896 0.0634535052385485 0.0734962749207326 0.85443194762848 NA NA NA 0.870844190607635 99.727107917785 a9895 loss_cnaBRCA17 224 AS605240 PI3Kgamma 11 38 2.99573227355399 2.32630161961136 3.19233459143412 3.29281316344984 -0.100478572015712 1.11717403989379 1.69750115195899 0.0631208157084563 0.0899399452794885 0.0591920493837403 0.854525546121344 NA NA NA 0.819249509668603 99.727107917785 a9896 BRCA2_mut 166 FTI-277 Farnesyl transferase (FNTA) 6 41 0.0237165266173161 NA 2.30209237544927 2.2359433611062 0.066149014343067 0.48145177253492 0.854069748528625 0.0805652435708158 0.137394892108886 0.0774515365484227 0.854592584882558 NA NA NA 0.786108485635355 99.727107917785 a9897 loss_cnaBRCA36_(FAT1,IRF2) 94 TGX221 PI3Kbeta 3 11 2.30258509299405 NA 3.64323634683353 3.80351354773342 -0.160277200899891 1.81556870886967 1.18938767308679 0.121918149836005 0.0882793364508224 0.13475606358348 0.854646358275441 NA NA NA 0.895865270178142 99.727107917785 a9898 loss_cnaBRCA20 179 5-Fluorouracil DNA antimetabolite 3 46 3.46573590279973 NA 4.20934637925229 4.03052866471493 0.178817714537361 1.17925921844375 1.64684035461974 0.10972576074462 0.151635630013005 0.108582300667906 0.854695176972361 NA NA NA 0.823230684068962 99.727107917785 a9899 loss_cnaBRCA33 1016 Temsirolimus MTOR 5 39 -1.6094379124341 NA -1.86803106165055 -1.7359294075082 -0.132101654142346 1.82695059639682 1.47302899029163 0.0874663921291133 0.0723071846621807 0.0896802812524365 0.854795107017515 NA NA NA 0.883013975739277 99.727107917785 a9900 loss_cnaBRCA34 287 KIN001-244 PDPK1 (PDK1) 5 44 2.99573227355399 NA 3.4040999684585 3.48651582292522 -0.0824158544667202 0.450898100281425 0.983031723788794 0.086805889940067 0.182781551785827 0.0838384484165715 0.854856358697066 NA NA NA 0.749246738487726 99.727107917785 a9901 gain_cnaBRCA27_(CLTC,PPM1D) 225 Genentech Cpd 10 AURKA, AURKB 9 40 2.32630161961136 NA 2.92809331050322 3.03830672757403 -0.110213417070809 1.72568079463994 1.60374127053857 0.0678176648838644 0.0638666301514965 0.0687226918053916 0.85494436190527 NA NA NA 0.863923215008865 99.727107917785 a9902 PIK3CA_mut 179 5-Fluorouracil DNA antimetabolite 17 32 3.46573590279973 NA 3.98289581234128 4.07259777827631 -0.0897019659350331 1.48415925221803 1.69992513909179 0.0550425778643461 0.0604395827475902 0.0527681860055072 0.855272813709334 NA NA NA 0.849341988820711 99.727107917785 a9903 loss_cnaBRCA33 223 ZSTK474 PI3K 6 43 1.63315443905142 2.32630161961136 1.01448173120436 0.898085342280649 0.116396388923709 1.08943352099619 1.4957383945899 0.0798380207854228 0.106841203873803 0.0778186809569882 0.855430404641502 NA NA NA 0.821776051546202 99.727107917785 a9904 gain_cnaBRCA30_(CRNKL1,FOXA2) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 40 2.30258509299405 NA 3.27825412674382 3.16419358465291 0.11406054209091 0.996244261752115 1.34056588474585 0.0869130383232563 0.114490538585697 0.0850838764351623 0.855479761758857 NA NA NA 0.824876694604838 99.727107917785 a9905 MACF1_mut 1069 EHT 1864 Rac GTPases 3 43 2.30258509299405 NA 3.47293961069869 3.56759486125087 -0.0946552505521803 0.239256879067195 0.884064963291861 0.109397196555744 0.39562185597847 0.107068207068999 0.855483785245244 NA NA NA 0.638238940946217 99.727107917785 a9906 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 4 10 1.38629436111989 NA 1.85571013077282 1.94653307913842 -0.0908229483655985 0.98570955629518 0.76572081023985 0.109924849669008 0.0921396650621501 0.118611048767435 0.855699986243224 NA NA NA 0.875748982002604 99.727107917785 a9907 loss_cnaBRCA20 1378 Bleomycin (50 uM) DNA damage 3 45 3.91202300542815 NA 3.61860612975822 3.82565837873147 -0.207052248973246 1.1459355451565 1.92689106394768 0.108996418519902 0.180684026992957 0.107454050126244 0.855764056815341 NA NA NA 0.793846933323763 99.727107917785 a9908 ARID1A_mut 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 4 39 0.693147180559945 NA 2.99232043063011 2.89981338714536 0.0925070434847517 0.442545736673744 0.993091730716054 0.0960080528404823 0.209033859822155 0.0931505525859639 0.855803524451989 NA NA NA 0.744547139039346 99.727107917785 a9909 loss_cnaBRCA42 171 AKT inhibitor VIII AKT1, AKT2, AKT3 3 44 0.940007258491471 NA 2.01753579276041 1.87987162739526 0.137664165365155 1.56593106432989 1.24667226085479 0.109034277783578 0.0879120214810131 0.110425305581729 0.855833522723225 NA NA NA 0.894172515595663 99.727107917785 a9910 loss_cnaBRCA60 301 PHA-793887 CDK-pan 3 45 2.32630161961136 NA 2.75345487329292 2.93352424167018 -0.180069368377261 0.506359495439098 1.68730970091578 0.108895645963135 0.355615664363342 0.106719808627622 0.855895902140747 NA NA NA 0.657279212810886 99.727107917785 a9911 loss_cnaBRCA28_(GPS2) 1030 KU-55933 ATM 3 39 2.30258509299405 NA 4.12773620654485 4.22957344339428 -0.101837236849422 0.330518487911239 0.951088278469582 0.109508572046791 0.308113586907039 0.107074431632457 0.855897946739534 NA NA NA 0.693115063067686 99.727107917785 a9912 loss_cnaBRCA34 1067 CCT007093 PPM1D 4 42 1.88706964903238 NA 4.17227572354804 4.07738484298799 0.0948908805600475 0.380949209867616 1.02360613551175 0.0955512530656963 0.249090634924858 0.0927025320267421 0.855946916977695 NA NA NA 0.711042540736383 99.727107917785 a9913 ARID1A_mut 277 ABT-869 VEGFR and PDGFR family 5 43 0.0237165266173161 NA 2.65407493189463 2.695380959091 -0.0413060271963701 0.510924050079638 0.475704681951217 0.0862572739930098 0.0808457288122015 0.0868312395559016 0.855949183124385 NA NA NA 0.870169559968245 99.727107917785 a9914 loss_cnaBRCA34 1494 SN-38 TOP1 5 43 -2.99573227355399 NA -3.17291524619117 -3.31900633128782 0.14609108509665 1.29689467431701 1.72886237133352 0.0861551710424782 0.112646838629041 0.0845012810267632 0.856117774057229 NA NA NA 0.826501947919765 99.727107917785 a9915 loss_cnaBRCA20 1039 SL 0101-1 RSK, AURKB, PIM3 3 40 2.30258509299405 NA 4.55019173645183 4.65622610585862 -0.106034369406791 0.831545205327628 0.978759036875688 0.109078169106562 0.127514858756252 0.108335520196334 0.856308658762811 NA NA NA 0.849815097334018 99.727107917785 a9916 gain_cnaBRCA47_(EGFR) 1527 GDC0941 (rescreen) PI3K 6 39 1.38629436111989 NA 1.06127475210083 0.968252932019428 0.0930218200813998 0.334915251938537 1.23336556377844 0.0798433556040286 0.277747339193949 0.0754211263985884 0.856382745528466 NA NA NA 0.701274774376514 99.727107917785 a9917 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1019 Bosutinib SRC, ABL, TEC 15 30 0.693147180559945 NA 2.69868685058837 2.64455438067079 0.0541324699175818 1.00586864216758 0.90850806959655 0.0575074014088856 0.0538166393187585 0.0595839175557582 0.856551597098611 NA NA NA 0.861937026783141 99.727107917785 a9918 NF1_mut 170 Shikonin unknown 4 43 2.77258872223978 NA 0.10750705745673 -0.00605702082847647 0.113564078285206 0.491512864237531 1.23038882907614 0.0949989943186054 0.231050063076934 0.092299341152567 0.856608255374154 NA NA NA 0.723767898283432 99.727107917785 a9919 gain_cnaBRCA8_(CHD4,WNK1) 1010 Gefitinib EGFR 3 42 -0.693147180559945 NA 1.29352327061995 1.40749599639718 -0.113972725777223 0.546421290428968 1.06822995692885 0.108573652462005 0.208580316641303 0.106693062704302 0.856688794203662 NA NA NA 0.768429163905715 99.727107917785 a9920 MLL3_mut 341 EX-527 SIRT1 3 46 2.99573227355399 NA 5.57480890368523 5.64611917369047 -0.071310270005239 1.04127177376681 0.636907957989488 0.108179041512814 0.0684838212287977 0.111963226570983 0.856720394294807 NA NA NA 0.916963839514921 99.727107917785 a9921 loss_cnaBRCA7_(FAS,PTEN) 175 PAC-1 CASP3 agonist 4 44 0.940007258491471 NA 2.50829193546927 2.39166269736937 0.116629238099901 1.20065249275043 1.23360569700175 0.0947062972777896 0.0971382134332049 0.094543368584764 0.856890564657265 NA NA NA 0.862753121208891 99.727107917785 a9922 gain_cnaBRCA8_(CHD4,WNK1) 1194 SB-505124 TGFR1 (ALK5) 3 44 2.30258509299405 NA 4.29537199867729 4.39538275451102 -0.100010755833739 0.811886557674241 0.929768611473167 0.108137444731327 0.123183165047385 0.107565209880851 0.857006066934212 NA NA NA 0.854256434366032 99.727107917785 a9923 ASH1L_mut 254 AC220 FLT3 3 45 0.0237165266173161 NA 2.31387632115333 2.21775426893803 0.0961220522153017 0.503000908078231 0.903292956694602 0.108045757679447 0.191097174322301 0.106412932264012 0.857008014600327 NA NA NA 0.783900579025294 99.727107917785 a9924 gain_cnaBRCA47_(EGFR) 1259 BMN-673 PARP1 6 40 2.30258509299405 NA 3.19739791753574 3.32175905894073 -0.124361141404989 1.19801307984593 1.61009506553619 0.0792751154659785 0.103806163302476 0.0772383842835851 0.857138581393699 NA NA NA 0.827208416919942 99.727107917785 a9925 gain_cnaBRCA62 1378 Bleomycin (50 uM) DNA damage 9 39 3.91202300542815 NA 3.916017158116 3.78887925664479 0.127137901471205 2.23954562562633 1.82000721027073 0.0669274392908518 0.0567695071787825 0.0698557130728582 0.857176193379515 NA NA NA 0.876936193633785 99.727107917785 a9926 PTEN_mut 175 PAC-1 CASP3 agonist 8 40 0.940007258491471 NA 2.32945630169404 2.41576690031442 -0.0863105986203863 1.34400160524808 1.21018327306812 0.0700865831610232 0.0642191186999773 0.0713202706905436 0.857191766993341 NA NA NA 0.869763157088795 99.727107917785 a9927 ASH1L_mut 301 PHA-793887 CDK-pan 3 45 2.32630161961136 NA 2.75505706962515 2.93341742858136 -0.178360358956211 0.775694318302436 1.68266385484804 0.107861396212491 0.229936399877909 0.105998805668955 0.857249297665467 NA NA NA 0.748452623044942 99.727107917785 a9928 loss_cnaBRCA34 1373 Dabrafenib BRAF 5 41 2.30258509299405 NA 4.08877497351446 4.22993232153751 -0.141157348023049 1.25579142670996 1.68161161829592 0.0856820649725243 0.112405089747162 0.0839417059725675 0.857293224139208 NA NA NA 0.82756313446941 99.727107917785 a9929 gain_cnaBRCA19 179 5-Fluorouracil DNA antimetabolite 4 45 3.46573590279973 NA 3.90031140348039 4.05402471334938 -0.153713309868998 0.975276117245608 1.66497893992402 0.0943200162266381 0.157610042070053 0.0923214739737264 0.857320259699577 NA NA NA 0.790629056962797 99.727107917785 a9930 loss_cnaBRCA23 262 VX-11e ERK 3 46 1.63315443905142 NA 3.91221008862443 3.76798163086294 0.144228457761489 0.260598439065308 1.36840911391071 0.107628662417032 0.553450965703385 0.105398638678535 0.857441276160112 NA NA NA 0.575898375175614 99.727107917785 a9931 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1061 SB590885 BRAF 8 34 1.6094379124341 NA 3.94882494980897 4.02675563679265 -0.0779306869836782 1.16382353126572 1.08223552874451 0.0710429604206462 0.0669609136523686 0.0720089896457978 0.85744323761966 NA NA NA 0.866358938460143 99.727107917785 a9932 gain_cnaBRCA31 304 SB52334 ALK5 16 33 2.99573227355399 NA 4.25437831609199 4.32492856320433 -0.0705502471123411 1.37404786585361 1.23708228553864 0.0550148705554477 0.0513448249261045 0.0570295508528947 0.857464137587735 NA NA NA 0.863147142439806 99.727107917785 a9933 loss_cnaBRCA20 1192 GSK269962A ROCK1, ROCK2 3 43 1.6094379124341 NA 2.81666033136225 2.65756805486143 0.159092276500815 1.79537051200031 1.45769245775804 0.107879661894045 0.0886125039023634 0.109139809055129 0.857466131269861 NA NA NA 0.893417978454962 99.727107917785 a9934 loss_cnaBRCA18 1010 Gefitinib EGFR 14 31 -0.693147180559945 NA 1.44193087811178 1.38091514087021 0.0610157372415703 1.01089404253853 1.06612312100906 0.0581250368127661 0.0603581925246576 0.0572314173093071 0.857600088383517 NA NA NA 0.855218399947188 99.727107917785 a9935 gain_cnaBRCA27_(CLTC,PPM1D) 268 YM155 BIRC5 (Survivin) 9 40 1.63315443905142 NA -3.50816812860093 -3.61524522348638 0.107077094885456 1.91851247696771 1.53857030711708 0.0665245605777199 0.0558125611227172 0.0695951913215412 0.857679428553907 NA NA NA 0.878626907242082 99.727107917785 a9936 gain_cnaBRCA31 1016 Temsirolimus MTOR 14 30 -1.6094379124341 NA -1.81107103731012 -1.7228802559577 -0.0881907813524139 1.48881657830184 1.51988619169104 0.0583914319107147 0.0592354912201509 0.058024595416774 0.857702677501748 NA NA NA 0.857154048567354 99.727107917785 a9937 loss_cnaBRCA17 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 8 37 2.30258509299405 NA 3.25257376235612 3.16049794381045 0.0920758185456654 0.798434602307928 1.39041500431674 0.0701599164550055 0.11532042609315 0.0662218246061808 0.858044680354621 NA NA NA 0.802808729343204 99.727107917785 a9938 TP53_mut 59 WZ-1-84 BMX 9 3 2.32630161961136 NA 3.52381000039335 3.6761581218669 -0.152348121473547 1.32345070620375 0.868163014066584 0.122291706872333 0.115114314994436 0.175483312471386 0.858120727741416 NA NA NA 0.82779714013173 99.727107917785 a9939 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 345 KIN001-270 CDK9 9 40 2.99573227355399 NA 5.14521215500499 5.09912132564028 0.0460908293647089 0.34724116470567 0.746788372632487 0.0662995506857959 0.132734347334011 0.0617187292328014 0.858155531941615 NA NA NA 0.782539155505322 99.727107917785 a9940 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 330 XMD13-2 RIPK 7 41 2.32630161961136 NA 3.64410509932602 3.73415326908204 -0.0900481697560163 1.51672883170367 1.17543821999009 0.0734872890841899 0.0593699861661293 0.0766081689574254 0.85818236695595 NA NA NA 0.885143027652963 99.727107917785 a9941 loss_cnaBRCA20 1017 Olaparib PARP1, PARP2 3 42 1.6094379124341 NA 4.16396124056145 4.06767930190753 0.0962819386539193 0.848767537507472 0.898566895884097 0.107420115399418 0.113437348153848 0.107150551722905 0.858194611265754 NA NA NA 0.865251861900649 99.727107917785 a9942 CDH1_mut 164 JQ12 HDAC 4 43 1.63315443905142 NA 1.71998259231481 1.56466462051622 0.155317971798595 1.20477750048851 1.68105116258186 0.0939287103717206 0.128918386785624 0.0923933638997923 0.85820595689843 NA NA NA 0.823654905308402 99.727107917785 a9943 loss_cnaBRCA18 45 Z-LLNle-CHO g-secretase 5 7 0.940007258491471 NA 0.876133369514508 1.04537156670496 -0.169238197190456 1.21869592100226 1.7759505397194 0.107326063003388 0.138868272449189 0.0952944315764536 0.858230292652015 NA NA NA 0.848740996566954 99.727107917785 a9944 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 282 EKB-569 EGFR 9 38 0.916290731874155 2.99573227355399 1.69276554978365 1.55090211312634 0.141863436657307 1.72621414366923 2.20936912109592 0.066555859365041 0.082181829628486 0.0642099300215341 0.858323204562728 NA NA NA 0.837067215683719 99.727107917785 a9945 MLL3_mut 179 5-Fluorouracil DNA antimetabolite 3 46 3.46573590279973 NA 4.20509084185887 4.03080619976233 0.17428464209654 1.00488399214777 1.65200195565024 0.106942255058451 0.173437574345308 0.105499053133953 0.858340498622863 NA NA NA 0.801203491833338 99.727107917785 a9946 loss_cnaBRCA20 1019 Bosutinib SRC, ABL, TEC 3 42 0.693147180559945 NA 2.75683595317975 2.65586729331928 0.10096865986047 0.741269957305204 0.950004114038641 0.107262563323838 0.136210376348624 0.106282339590335 0.858400319944283 NA NA NA 0.840370216630894 99.727107917785 a9947 loss_cnaBRCA17 37 Crizotinib MET, ALK 4 10 0.693147180559945 NA 2.59047620824254 2.67701899187032 -0.0865427836277761 0.820588838776434 0.798167438979682 0.107662852169492 0.105464246573008 0.108426853065324 0.85863369062789 NA NA NA 0.863924616928359 99.727107917785 a9948 gain_cnaBRCA19 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 40 1.6094379124341 NA 2.40604860886068 2.57943835684587 -0.173389747985187 1.20554787731501 1.63468885168542 0.107269043299783 0.143826513444957 0.106068960956341 0.858665639809138 NA NA NA 0.832576418565342 99.727107917785 a9949 loss_cnaBRCA60 257 NPK76-II-72-1 PLK3 3 46 2.32630161961136 NA 3.31922085353804 3.48937808686392 -0.170157233325879 1.88444777326397 1.58190568129547 0.106618242775762 0.0902955421423843 0.107564714722139 0.858765034314575 NA NA NA 0.891415107498105 99.727107917785 a9950 gain_cnaBRCA27_(CLTC,PPM1D) 287 KIN001-244 PDPK1 (PDK1) 9 40 2.99573227355399 NA 3.52906053382293 3.46664128116489 0.0624192526580409 0.951241411930929 0.949079648696227 0.0657426794846048 0.0656187292470119 0.0657681921046224 0.859334056624507 NA NA NA 0.861776017594641 99.727107917785 a9951 loss_cnaBRCA20 287 KIN001-244 PDPK1 (PDK1) 3 46 2.99573227355399 NA 3.57268672959448 3.47193773613519 0.100748993459287 0.869916700762184 0.952829060165983 0.10611318658484 0.115814529564744 0.105736692625366 0.859426866027013 NA NA NA 0.862410010390766 99.727107917785 a9952 BRCA1_mut 1003 Camptothecin TOP1 4 41 -2.30258509299405 NA -2.39316432142934 -2.54256116330745 0.149396841878115 1.50657271241177 1.60760553483991 0.0933284810011049 0.0991633796678527 0.0929312811136796 0.859427730354244 NA NA NA 0.860620335444756 99.727107917785 a9953 PTEN_mut 231 FMK RSK 9 40 2.99573227355399 2.32630161961136 5.62127474521217 5.58201956160245 0.0392551836097219 0.598490170127066 0.597433459446469 0.0656865790868391 0.0655903564821919 0.0657063694525787 0.85945280170982 NA NA NA 0.861846766401249 99.727107917785 a9954 gain_cnaBRCA63 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 6 40 2.30258509299405 NA 1.48114777775429 1.40297898591489 0.0781687918393961 1.89551054952138 0.820753844615116 0.0779594335853313 0.0412389115212965 0.0952402384128368 0.859483842814949 NA NA NA 0.924313247354766 99.727107917785 a9955 POLR2B_mut 1019 Bosutinib SRC, ABL, TEC 3 42 0.693147180559945 NA 2.56914053578741 2.66927410884731 -0.100133573059897 0.49566463757452 0.957777994332405 0.106374764805246 0.202018795510387 0.104547790461288 0.859559664301461 NA NA NA 0.775053317919199 99.727107917785 a9956 gain_cnaBRCA58_(CCND1) 1114 Cetuximab EGFR 9 36 4.18661983833127 NA 6.23569223094135 6.29430826118101 -0.058616030239663 0.682999709455684 0.924442628555475 0.0662682004611804 0.0858214570638353 0.0634068880307432 0.859702332719388 NA NA NA 0.833806666884709 99.727107917785 a9957 gain_cnaBRCA27_(CLTC,PPM1D) 185 OSI-906 IGF1R 9 39 0.940007258491471 NA 2.83287690578927 2.90747752955223 -0.0746006237629535 1.45037754249021 1.05807126168727 0.0656654116621061 0.0514353136183211 0.070506237589319 0.859840309801845 NA NA NA 0.887097570989337 99.727107917785 a9958 gain_cnaBRCA10_(MDM2,NUP107) 1378 Bleomycin (50 uM) DNA damage 3 45 3.91202300542815 NA 3.62420971837399 3.82528480615709 -0.2010750877831 1.71554684609326 1.90761035127163 0.105847734643628 0.117207576255349 0.10540679214131 0.859885569408471 NA NA NA 0.86093967846877 99.727107917785 a9959 loss_cnaBRCA42 310 YM201636 FYV1 3 46 1.63315443905142 NA 2.51622736128694 2.40804401352852 0.108183347758424 1.02448915360391 1.02420213418094 0.105625690384577 0.105597357842063 0.105626950138059 0.860065783624201 NA NA NA 0.873922445759888 99.727107917785 a9960 gain_cnaBRCA9_(KRAS) 266 Zibotentan, ZD4054 Endothelin A Receptor 4 45 2.99573227355399 NA 5.78413885515999 5.73829720933348 0.0458416458265116 0.43145718087635 0.500039992492582 0.0924327714769416 0.106248424776245 0.0916759589528065 0.860144461181103 NA NA NA 0.851223406553929 99.727107917785 a9961 BRCA2_mut 1199 Tamoxifen ER 5 42 1.6094379124341 NA 3.94106638728722 3.86061115503216 0.0804552322550589 0.683971200269201 0.982963867088924 0.0837931864813447 0.117629561337368 0.081849633489916 0.860208375354522 NA NA NA 0.82133057145371 99.727107917785 a9962 BRCA1_mut 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 4 44 2.32630161961136 NA 5.01787028754724 4.95309223219808 0.0647780553491533 0.486515373187333 0.713454101687729 0.0924216303838547 0.133146985520251 0.0907949862449679 0.860305787197952 NA NA NA 0.818822239479021 99.727107917785 a9963 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 54 CGP-082996 CDK4 3 9 1.63315443905142 NA 2.71380285302736 2.84084938538837 -0.127046532361007 1.31220851023847 0.981167507854414 0.120341920694843 0.0968188602418972 0.129485058712175 0.860355749865982 NA NA NA 0.888091752715798 99.727107917785 a9964 gain_cnaBRCA27_(CLTC,PPM1D) 54 CGP-082996 CDK4 3 9 1.63315443905142 NA 2.71380285302736 2.84084938538837 -0.127046532361007 1.31220851023847 0.981167507854414 0.120341920694843 0.0968188602418972 0.129485058712175 0.860355749865982 NA NA NA 0.888091752715798 99.727107917785 a9965 gain_cnaBRCA31 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 13 30 -1.38629436111989 0.693147180559945 -2.2598659519235 -2.20345740277421 -0.0564085491492898 1.07607208583227 0.907909910055591 0.0587478012219517 0.0524207902908859 0.0621301172335876 0.860438268356239 NA NA NA 0.870440161281478 99.727107917785 a9966 ARID1A_mut 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 5 40 -0.669430653942629 NA -3.30361794929804 -3.50901318283997 0.205395233541927 2.54548642766122 2.4398628555527 0.0838388814001083 0.0806899739515185 0.0841831060604426 0.860536305865196 NA NA NA 0.871061781043524 99.727107917785 a9967 loss_cnaBRCA60 279 BIX02189 MAP2K5 (MEK5) 3 46 2.99573227355399 NA 4.9378042330833 5.03319638007537 -0.095392146992066 0.663716533494399 0.915679759528819 0.105244518518716 0.143724228911153 0.104176319285633 0.860565417343141 NA NA NA 0.832081837939425 99.727107917785 a9968 PIK3CA_mut 268 YM155 BIRC5 (Survivin) 17 32 1.63315443905142 NA -3.65122677594446 -3.56601459080649 -0.0852121851379737 1.67711146384156 1.57364015390714 0.0529396024817429 0.0508088979028193 0.054149727259058 0.860742851446627 NA NA NA 0.863840288342032 99.727107917785 a9969 MACF1_mut 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 3 42 2.30258509299405 NA 1.47463177327854 1.35751631833453 0.117115454944004 0.722852688499764 1.12634275589054 0.105430544889169 0.162018426170718 0.10397852192995 0.860793031311948 NA NA NA 0.813755602604534 99.727107917785 a9970 gain_cnaBRCA16 226 GSK1070916 AURKB 16 33 0.940007258491471 2.32630161961136 2.47491169283081 2.36954092927152 0.105370763559285 2.12572772946487 1.87984343407891 0.053714867028188 0.0495692661382421 0.0560529465640925 0.860796352116187 NA NA NA 0.867197223061128 99.727107917785 a9971 NF1_mut 185 OSI-906 IGF1R 5 43 0.940007258491471 NA 2.80874385967804 2.90334410479652 -0.094600245118476 0.691098000121368 1.16966079201524 0.083269170753609 0.136883980422259 0.0808783587209812 0.860885872569776 NA NA NA 0.798533093856232 99.727107917785 a9972 loss_cnaBRCA38 281 CH5424802 ALK 4 44 1.63315443905142 NA 3.66564626125289 3.56702084102862 0.0986254202242614 0.886497042061095 1.08449427336169 0.09194163219249 0.111252960297486 0.0909413932805237 0.861023655510356 NA NA NA 0.845170544150209 99.727107917785 a9973 PTEN_mut 1203 QL-XII-61 BTK 4 19 2.30258509299405 NA 4.1017777616644 4.25119699099712 -0.149419229332717 1.4152233961206 1.55277984417785 0.0974123165278923 0.105579959844011 0.0962269248232226 0.861146386843149 NA NA NA 0.858330470615507 99.727107917785 a9974 gain_cnaBRCA13_(FGFR1,WHSC1L1) 170 Shikonin unknown 10 37 2.77258872223978 NA -0.0553933967270028 0.0195543324722286 -0.0749477291992314 1.21240650370738 1.19117525616356 0.0626940686849892 0.061817326919685 0.0629191454501977 0.861157724613565 NA NA NA 0.864275450683593 99.727107917785 a9975 gain_cnaBRCA48 1038 NU-7441 PRKDC (DNAPK) 4 39 0.693147180559945 NA 2.81309640547703 2.90104641159043 -0.0879500061133984 0.313362405823798 0.9854380212519 0.0923379139673409 0.280665467455124 0.0892496577325754 0.861256678033994 NA NA NA 0.69985792809518 99.727107917785 a9976 MLL3_mut 300 CX-5461 RNA Pol I 3 46 2.32630161961136 NA 4.08131242297703 3.90134700215286 0.179965420824169 1.57587963079959 1.72625070737684 0.104623774838653 0.114199979050973 0.104252192369925 0.861379201019023 NA NA NA 0.864295819996695 99.727107917785 a9977 loss_cnaBRCA34 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 38 1.6094379124341 NA 2.68662853640108 2.55164572153714 0.134982814863934 1.41073195444327 1.63711613441854 0.0835069455468647 0.0956828222673979 0.082451581794395 0.861522895317106 NA NA NA 0.850728290963349 99.727107917785 a9978 gain_cnaBRCA16 52 GNF-2 ABL [T315I] 3 9 0.246860077931526 NA 2.43461641933367 2.50424492233643 -0.0696285030027632 0.576754291729759 0.586528228919127 0.119107268543713 0.12072472455114 0.118712961405245 0.861771690829893 NA NA NA 0.866818392445229 99.727107917785 a9979 gain_cnaBRCA47_(EGFR) 299 OSI-027 MTORC1/2 7 41 2.99573227355399 NA 1.39124839788706 1.24809268948907 0.143155708397986 1.16946270936978 2.09561270035096 0.0716032385897365 0.122411520479462 0.068312101932772 0.861779970118409 NA NA NA 0.798495985380061 99.727107917785 a9980 gain_cnaBRCA58_(CCND1) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 8 35 0.693147180559945 NA 2.85463463833343 2.92071219184349 -0.0660775535100546 0.793190127542844 0.995030088931034 0.0685759606602416 0.0833060715401876 0.0664075933432747 0.861947724392818 NA NA NA 0.843087115999105 99.727107917785 a9981 PIK3CA_mut 1049 PD-173074 FGFR1, FGFR3 15 28 0.693147180559945 NA 2.895845524666 2.96022031055987 -0.0643747858938664 1.39967845808811 0.999775705388643 0.0558788250980478 0.0459925531623879 0.0643892280507476 0.862223960794371 NA NA NA 0.87601924638366 99.727107917785 a9982 loss_cnaBRCA28_(GPS2) 1013 Nilotinib ABL 3 37 0.693147180559945 NA 3.29663090682563 3.19530817772285 0.101322729102772 0.401443862648506 0.988035870160677 0.104879900304923 0.252395760728038 0.102549646387124 0.86223317505108 NA NA NA 0.736908898114748 99.727107917785 a9983 loss_cnaBRCA36_(FAT1,IRF2) 261 TL-1-85 MAP3K7 (TAK1) 9 40 2.32630161961136 NA 3.96070104661271 4.03923018529195 -0.0785291386792468 1.2750881737824 1.20904930147098 0.0643395459257511 0.0615872221967986 0.0649511468090712 0.862304982721131 NA NA NA 0.869123360662977 99.727107917785 a9984 loss_cnaBRCA34 1039 SL 0101-1 RSK, AURKB, PIM3 5 38 2.30258509299405 NA 4.57753441943972 4.65820914069741 -0.0806747212576893 0.618180864522426 1.00293843810189 0.0829877480312194 0.130503426889498 0.0804383581213318 0.862374932092675 NA NA NA 0.808499561101447 99.727107917785 a9985 BRCA2_mut 1006 Cytarabine DNA synthesis 5 40 0.693147180559945 NA 1.09535579280128 1.22268046004306 -0.127324667241778 1.60585150190765 1.53339363811772 0.0826634490078939 0.0792879460463961 0.0830345607785827 0.862471299928932 NA NA NA 0.873237863830386 99.727107917785 a9986 TP53_mut 1114 Cetuximab EGFR 36 9 4.18661983833127 NA 6.27109813495054 6.32853273586322 -0.0574346009126812 0.957612809493146 0.439873817968236 0.0649315859898355 0.0599768511274203 0.130570628590649 0.862502638130353 NA NA NA 0.792885098665598 99.727107917785 a9987 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1373 Dabrafenib BRAF 14 32 2.30258509299405 NA 4.2784718145491 4.18664045771633 0.091831356832774 1.01729371910834 1.84892206673755 0.0557397878149555 0.0902702485111814 0.0496675108620516 0.862702322118606 NA NA NA 0.830047857872551 99.727107917785 a9988 BRCA2_mut 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 37 -1.38629436111989 0.693147180559945 -0.426999905543415 -0.285378150336065 -0.14162175520735 0.987824582479894 1.77213296713068 0.0828213052329096 0.143367312090791 0.0799159870247514 0.862882529295278 NA NA NA 0.795705825049121 99.727107917785 a9989 gain_cnaBRCA47_(EGFR) 194 AUY922 HSP90 7 40 -1.36257783450257 NA -2.49915030346192 -2.37530150979932 -0.123848793662602 1.52471881158204 1.77122728475226 0.07116200798331 0.0812273008779223 0.0699225868575782 0.862887005696502 NA NA NA 0.85098018990465 99.727107917785 a9990 BRCA1_mut 1038 NU-7441 PRKDC (DNAPK) 4 39 0.693147180559945 NA 2.97166275776818 2.88478319597083 0.086879561797355 0.363785992907839 0.984078432819549 0.0912132317216997 0.23882052495453 0.0882852005489345 0.862929136519024 NA NA NA 0.72660566167026 99.727107917785 a9991 loss_cnaBRCA38 254 AC220 FLT3 4 44 0.0237165266173161 NA 2.29764866494742 2.2170449183155 0.080603746631926 0.282068398999248 0.917159101079516 0.0905997520358878 0.285759577882175 0.0878841484940331 0.863031151419219 NA NA NA 0.691138867501959 99.727107917785 a9992 gain_cnaBRCA63 196 Phenformin AAPK1 (AMPK) agonist 7 41 8.29404964010203 NA 7.31256868853166 7.1831377369439 0.129430951587763 3.22170156173414 1.50736438977648 0.0709318779161494 0.0401747179580761 0.085865735230056 0.863062656676947 NA NA NA 0.920051267109699 99.727107917785 a9993 BRCA2_mut 258 STF-62247 stimulates autophagy 6 43 2.32630161961136 NA 4.56663272519739 4.63980246540789 -0.0731697402105027 0.711656520025355 0.994286695199624 0.0755769057587893 0.102816089154773 0.0735901833583445 0.863065508890245 NA NA NA 0.828905085989573 99.727107917785 a9994 gain_cnaBRCA31 1194 SB-505124 TGFR1 (ALK5) 15 32 2.30258509299405 NA 4.42313210790712 4.37299923674719 0.0501328711599349 1.03581027640036 0.870155673244426 0.0542048691368582 0.0483996657516823 0.0576136807486545 0.863251601787368 NA NA NA 0.872300606908225 99.727107917785 a9995 CDH1_mut 200 LAQ824 HDAC 4 44 0.0237165266173161 NA -2.80215915685444 -2.67376816016049 -0.12839099669395 0.405076549242233 1.4658427231744 0.0903520530459638 0.316954898855852 0.0875885213769107 0.863401817394993 NA NA NA 0.675381703966983 99.727107917785 a9996 loss_cnaBRCA7_(FAS,PTEN) 154 CHIR-99021 GSK3B 4 43 0.940007258491471 NA 3.19993261756083 3.28246050964653 -0.0825278920856989 1.15451035875592 0.892936885840075 0.0904206840174278 0.0714830243486334 0.0924229846413575 0.8634468532573 NA NA NA 0.897302905222045 99.727107917785 a9997 loss_cnaBRCA23 177 GSK-650394 SGK3 3 44 2.77258872223978 NA 3.84936053672507 4.02569414813186 -0.176333611406792 1.37707716424257 1.72237485577216 0.103208952418674 0.128049187064822 0.102378184874128 0.863455466698505 NA NA NA 0.849308275585184 99.727107917785 a9998 loss_cnaBRCA7_(FAS,PTEN) 1005 Cisplatin DNA crosslinker 4 41 1.79175946922805 2.30258509299405 3.7682149870534 3.66050975300398 0.107705234049417 1.18045850862482 1.19267444770055 0.0903699136662624 0.0912401691906043 0.0903056439727289 0.863838178751754 NA NA NA 0.871129193037646 99.727107917785 a9999 gain_cnaBRCA19 1261 rTRAIL TR10A (DR4), TR10B (DR5) 4 43 -2.30258509299405 NA -0.0545172150718547 -0.148614056704918 0.0940968416330632 0.86645335307127 1.05646099819344 0.0900560842320865 0.108600008643885 0.089067974865111 0.863991916198648 NA NA NA 0.848907241644237 99.727107917785 a10000 loss_cnaBRCA29_(MAP2K4) 1021 Axitinib PDGFR, KIT, VEGFR 6 39 0.693147180559945 NA 2.53953531963194 2.45047748231378 0.0890578373181548 0.831670419014769 1.21787201498163 0.075506016250565 0.107083088783723 0.0731257769475046 0.864103684057619 NA NA NA 0.825317602534529 99.727107917785 a10001 loss_cnaBRCA7_(FAS,PTEN) 277 ABT-869 VEGFR and PDGFR family 4 44 0.0237165266173161 NA 2.73053161592417 2.68749157810657 0.0430400378175917 0.488727206254139 0.478195453898656 0.0898746991324062 0.0880655655482596 0.0900051170848503 0.86411623506714 NA NA NA 0.875046190749537 99.727107917785 a10002 loss_cnaBRCA22_(SYNCRIP,ZNF292) 56 WH-4-023 SRC family, ABL 3 9 1.63315443905142 NA 3.12148746820146 3.25721658830664 -0.135729120105174 1.10068266972128 1.17518635571926 0.116940492849963 0.12331357968918 0.11549582706149 0.864257861672306 NA NA NA 0.86530581525053 99.727107917785 a10003 loss_cnaBRCA18 292 Masitinib KIT 15 33 2.99573227355399 NA 3.96995027353445 4.02868061223401 -0.0587303386995535 0.982172345665037 1.14421621708233 0.053516038168056 0.0597963676729125 0.0513280076114564 0.864304191846928 NA NA NA 0.856653367182735 99.727107917785 a10004 BRCA1_mut 197 Bryostatin 1 PRKC 4 44 -4.8283137373023 NA -2.7267406015036 -2.8140824068712 0.0873418053675996 0.791268590870398 0.984891889622464 0.0897249959626934 0.110381994654335 0.0886816170260881 0.864340307572461 NA NA NA 0.846596231986156 99.727107917785 a10005 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 156 AZD6482 PI3Kbeta 6 41 1.63315443905142 NA 1.9568359705794 2.06742792361177 -0.110591953032368 1.20451099946543 1.50284110171408 0.0750956728285395 0.0918148137139878 0.0735885869146319 0.864361836079457 NA NA NA 0.844566919115865 99.727107917785 a10006 loss_cnaBRCA18 9 MG-132 Proteasome 6 8 0 NA 0.417118250749168 0.263143586696246 0.153974664052923 1.52981762782983 1.70429087229253 0.0942398450761088 0.100649032441435 0.0903452964257231 0.864383299968515 NA NA NA 0.862257777814098 99.727107917785 a10007 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 276 CAY10603 HDAC6 7 42 2.99573227355399 NA 1.23556124423894 1.16553616225189 0.0700250819870489 1.50220733592136 0.901913457065661 0.0701063297038484 0.0466147916553077 0.0776405778608435 0.864391201755911 NA NA NA 0.908145653658732 99.727107917785 a10008 loss_cnaBRCA60 292 Masitinib KIT 3 45 2.99573227355399 NA 4.11568957487859 4.00330323515785 0.112386339720743 0.832907615810261 1.10795917722714 0.102408214382476 0.134932539440659 0.101435451802484 0.864392282345694 NA NA NA 0.84186057779374 99.727107917785 a10009 gain_cnaBRCA63 294 MPS-1-IN-1 MPS1 7 42 2.99573227355399 NA 4.82743025663052 4.74469894400813 0.0827313126223927 1.41026698167094 1.1432555688803 0.0700691719157357 0.0586635819299757 0.0723646705726693 0.864462359368382 NA NA NA 0.886805037196593 99.727107917785 a10010 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1043 JNK Inhibitor VIII JNK 4 39 2.30258509299405 NA 4.85881625661118 4.79102501959341 0.0677912370177678 0.444252964527643 0.771139159851444 0.0901414465818663 0.152596026207383 0.0879105102519076 0.864523527506886 NA NA NA 0.800110620398978 99.727107917785 a10011 loss_cnaBRCA42 253 XMD14-99 EPHB3, CAMK1 3 45 2.32630161961136 NA 5.00776190474874 4.92812450258792 0.0796374021608148 0.267672824935774 0.794170829196837 0.102267429662622 0.297517696015362 0.100277420465511 0.864576847038099 NA NA NA 0.699552168476872 99.727107917785 a10012 gain_cnaBRCA47_(EGFR) 238 CAL-101 PI3Kdelta 7 42 2.99573227355399 2.32630161961136 4.66186074241055 4.72848146560227 -0.0666207231917193 1.12971608710442 0.923352016018258 0.0699657916185891 0.058971208741902 0.0721509478898478 0.864660339852007 NA NA NA 0.886295814773293 99.727107917785 a10013 CDH1_mut 224 AS605240 PI3Kgamma 4 45 2.99573227355399 2.32630161961136 3.40092795492597 3.25864153104812 0.142286423877848 2.26237304577501 1.53558852011833 0.0893801714526153 0.0628925561783759 0.0926592130728379 0.864716474974577 NA NA NA 0.909114460274906 99.727107917785 a10014 MLL3_mut 150 Bicalutamide ANDR (androgen receptor) 3 45 0.0237165266173161 NA 2.70245527986451 2.76659657435858 -0.0641412944940707 0.676954137454217 0.625666543145137 0.102138495735768 0.0947498374635588 0.10251674026174 0.864745882379054 NA NA NA 0.886458354164075 99.727107917785 a10015 gain_cnaBRCA13_(FGFR1,WHSC1L1) 226 GSK1070916 AURKB 11 38 0.940007258491471 2.32630161961136 2.49309071573445 2.3781431546888 0.114947561045658 2.03146478677388 1.94242237073451 0.0585957103287606 0.0565835852996515 0.0591774285436137 0.864847013331955 NA NA NA 0.869596332875461 99.727107917785 a10016 gain_cnaBRCA16 208 SB-715992 KIF11 16 33 -2.05572501506252 NA -1.17950854769546 -1.26917964035326 0.0896710926577975 2.22733337487179 1.42149934384484 0.052128443968814 0.0402593943364941 0.063082049981998 0.864866189353437 NA NA NA 0.884400531336845 99.727107917785 a10017 loss_cnaBRCA7_(FAS,PTEN) 1268 XAV 939 TNKS1 (tankyrase-1) 4 43 1.6094379124341 NA 3.7388423904101 3.65424271324275 0.0845996771673536 0.469944076702253 0.97136602551449 0.0894060761755142 0.180020733022143 0.0870935105255971 0.864963819558227 NA NA NA 0.771337308110479 99.727107917785 a10018 loss_cnaBRCA22_(SYNCRIP,ZNF292) 222 BX-912 PDPK1 (PDK1) 19 30 2.32630161961136 NA 3.93043257770384 3.85423464124159 0.0761979364622469 1.73613593104661 1.37329286253662 0.0500477231118996 0.0438893839472072 0.0554855694228988 0.865195420464622 NA NA NA 0.872401945628302 99.727107917785 a10019 loss_cnaBRCA34 329 QL-XI-92 DDR1 5 43 2.32630161961136 NA 4.32219345508575 4.24532831250741 0.07686514257834 0.829139268799839 0.964552434825806 0.080610206358146 0.0927047427021525 0.0796899575420402 0.865283519182674 NA NA NA 0.85431314831765 99.727107917785 a10020 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 172 Embelin XIAP 9 39 3.46573590279973 NA 3.04300145612691 2.98153773141269 0.0614637247142191 0.730107932482871 1.0188962191685 0.0630502498348141 0.0841844362725934 0.0603238323569189 0.865366080676599 NA NA NA 0.836471218874354 99.727107917785 a10021 gain_cnaBRCA47_(EGFR) 167 OSU-03012 PDPK1 (PDK1) 7 41 2.77258872223978 NA 2.17700804491257 2.26009602462582 -0.0830879797132527 1.12129187254734 1.20300915308429 0.0696656435635109 0.0741002247028636 0.0690667893093169 0.865482907829292 NA NA NA 0.861937559693704 99.727107917785 a10022 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 136 Mitomycin C DNA crosslinker 15 33 2.77258872223978 NA -0.08000180320706 -0.158988686857662 0.0789868836506017 1.25301982260633 1.58168764847832 0.0530342462045621 0.0630372179478424 0.0499383577576722 0.865513757863865 NA NA NA 0.85361256743261 99.727107917785 a10023 gain_cnaBRCA8_(CHD4,WNK1) 153 Midostaurin KIT 3 44 -0.669430653942629 NA 0.751635150220045 0.602676035981587 0.148959114238458 0.997359991851009 1.4845771484689 0.101583952579512 0.149353408453856 0.10033773885856 0.865584019230058 NA NA NA 0.826909966862199 99.727107917785 a10024 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1239 YK 4-279 RNA helicase A 11 31 2.30258509299405 NA 1.95595565335459 2.03399060578622 -0.0780349524316302 1.27634203608379 1.31493650771438 0.0597788104683564 0.0611395301772441 0.059345034512176 0.865606588175113 NA NA NA 0.864706031581487 99.727107917785 a10025 BRCA1_mut 1039 SL 0101-1 RSK, AURKB, PIM3 4 39 2.30258509299405 NA 4.57002078883391 4.65691118688115 -0.0868903980472338 1.78308034757406 0.876740303164125 0.0893800572461189 0.0487305006560421 0.0991061979626685 0.865656520694058 NA NA NA 0.929102610665772 99.727107917785 a10026 BRCA2_mut 1031 Elesclomol HSP70 5 39 -1.6094379124341 NA -3.10650157401932 -2.96105054448759 -0.14545102953173 2.69257685074381 1.67804263779277 0.0808295012523352 0.0540192676363349 0.0866789831532829 0.865700301076485 NA NA NA 0.911334626294275 99.727107917785 a10027 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1054 PD-0332991 CDK4, CDK6 8 34 1.38629436111989 0.693147180559945 2.80303144713878 2.90169845388677 -0.0986670067479887 1.0852540183969 1.54832020907367 0.0667663456200618 0.0909160482941462 0.063725194678573 0.865937832847479 NA NA NA 0.835457682053846 99.727107917785 a10028 gain_cnaBRCA16 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 16 31 2.99573227355399 NA 3.79813384079595 3.87322546646925 -0.0750916256732954 1.36461107779266 1.47361685455637 0.0522122320099402 0.0550278587762608 0.0509573607556907 0.866073168389395 NA NA NA 0.863011085869849 99.727107917785 a10029 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 288 KIN001-055 JAK3, MNK1 7 42 2.32630161961136 NA 4.28791376220146 4.34752252752918 -0.0596087653277211 0.870787747745139 0.859942995634228 0.069205086184053 0.0684538401947834 0.0693171124485504 0.866117412706808 NA NA NA 0.870733038859342 99.727107917785 a10030 TP53_mut 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 35 10 -0.669430653942629 NA -3.51928763815393 -3.37035497247014 -0.148932665683787 2.33003860246242 2.8579045947221 0.0607900461628476 0.0639185400303639 0.0521125393614722 0.866170658904375 NA NA NA 0.882306493403059 99.727107917785 a10031 loss_cnaBRCA22_(SYNCRIP,ZNF292) 304 SB52334 ALK5 19 30 2.99573227355399 NA 4.34085876218405 4.27721263872393 0.0636461234601224 1.33285376629365 1.25012498964191 0.0496289652420517 0.0477517677255078 0.0509118080091763 0.866312352477032 NA NA NA 0.868444314227025 99.727107917785 a10032 loss_cnaBRCA38 1149 TW 37 BCL2, BCL2L1 3 40 1.6094379124341 NA -0.0239041081797232 -0.151270252367534 0.12736614418781 1.49626029489429 1.24370976810797 0.101308818526901 0.0851229860355341 0.102408252675839 0.866439922101965 NA NA NA 0.897733279290314 99.727107917785 a10033 gain_cnaBRCA47_(EGFR) 1036 PLX4720 BRAF 6 37 2.30258509299405 NA 4.67429213453106 4.58401949731929 0.0902726372117728 0.564006291998515 1.27634679433714 0.0744761834751141 0.160056081806993 0.0707273584360395 0.866453312994852 NA NA NA 0.775878061484136 99.727107917785 a10034 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1047 Nutlin-3a MDM2 4 39 2.07944154167984 1.38629436111989 4.125323335598 4.21531597651607 -0.0899926409180676 1.10772966264323 1.00551832154784 0.0888073434272657 0.0812406166892111 0.0894987579933282 0.866508942201816 NA NA NA 0.884530832447594 99.727107917785 a10035 CDH1_mut 230 GSK429286A ROCK2 4 45 2.99573227355399 2.32630161961136 5.33241218644106 5.41200059931099 -0.079588412869926 0.167845715305168 0.932676580098256 0.088097259771195 0.474176017691145 0.0853333455221332 0.866639353904548 NA NA NA 0.627926866133476 99.727107917785 a10036 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 291 KIN001-266 MAP3K8 (COT) 9 40 2.99573227355399 NA 3.71823893327893 3.79222339099041 -0.0739844577114837 0.859251336810521 1.24509748889701 0.0622606297596303 0.086103395528145 0.059420614346451 0.866710463706389 NA NA NA 0.834019839453071 99.727107917785 a10037 gain_cnaBRCA61_(NOTCH2) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 3 46 1.63315443905142 NA 3.48158791785412 3.58285704908526 -0.101269131231138 0.74553666358575 1.01715306205625 0.100556353393216 0.135833871327094 0.0995613492294018 0.866715235848449 NA NA NA 0.840972248600928 99.727107917785 a10038 loss_cnaBRCA28_(GPS2) 1018 ABT-888 PARP1, PARP2 3 42 1.6094379124341 NA 4.4660971549362 4.39857469467091 0.0675224602652875 0.474114143493379 0.677641652011698 0.100847746449748 0.142418152236014 0.0996433145230008 0.8667841520768 NA NA NA 0.834526925372411 99.727107917785 a10039 loss_cnaBRCA36_(FAT1,IRF2) 1114 Cetuximab EGFR 9 36 4.18661983833127 NA 6.23809164467367 6.29370840774793 -0.055616763074263 0.844784596095688 0.893402542647155 0.0628750816804319 0.0658354370230057 0.0622527476913938 0.866814648520295 NA NA NA 0.864111138256603 99.727107917785 a10040 gain_cnaBRCA8_(CHD4,WNK1) 263 FR-180204 ERK 4 45 2.99573227355399 NA 5.41750533461551 5.35258529423677 0.0649200403787411 0.605126183012967 0.746580452841521 0.0879244564923983 0.10728347607684 0.0869565230802016 0.866898420851005 NA NA NA 0.850564252965208 99.727107917785 a10041 loss_cnaBRCA42 254 AC220 FLT3 3 45 0.0237165266173161 NA 2.139982151093 2.22934721360872 -0.0893650625157241 0.185934739569069 0.908816421389842 0.100445717408545 0.48062595899422 0.0983312585605123 0.866965743676312 NA NA NA 0.614510652590047 99.727107917785 a10042 loss_cnaBRCA7_(FAS,PTEN) 157 JNK-9L JNK 4 43 1.63315443905142 NA -0.0298477038928699 0.0638156468231201 -0.0936633507159899 0.541696471110834 1.09137364825212 0.0880622836064667 0.172907441179963 0.0858215248883783 0.866973749487888 NA NA NA 0.77882243563279 99.727107917785 a10043 loss_cnaBRCA20 272 AR-42 HDAC 3 46 1.63315443905142 NA -0.00312280477668431 0.15143110455308 -0.154553909329764 1.03636883076722 1.55958265189141 0.100298362760214 0.149130217680658 0.0990995309817828 0.867053907080958 NA NA NA 0.827007253105401 99.727107917785 a10044 BRCA1_mut 1054 PD-0332991 CDK4, CDK6 4 38 1.38629436111989 0.693147180559945 3.00129019637875 2.87044311115119 0.130847085227558 0.666694227080893 1.5247758029094 0.0885415270514904 0.196262514227052 0.0858139832609426 0.867086309789125 NA NA NA 0.761730827591948 99.727107917785 a10045 loss_cnaBRCA23 151 QS11 ARFGAP 3 45 2.32630161961136 NA 3.9007574256414 3.75109605722987 0.149661368411528 1.83888612393442 1.47384387477758 0.100337866992467 0.0813869692438142 0.101544926822126 0.867107212568754 NA NA NA 0.901941983665025 99.727107917785 a10046 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1502 Bicalutamide ANDR (androgen receptor) 9 36 2.30258509299405 NA 4.52880532725321 4.56567758437288 -0.0368722571196756 0.867323044628517 0.502884079373293 0.0627032051269008 0.042512714666158 0.0733215837049897 0.867175221377621 NA NA NA 0.905090300295819 99.727107917785 a10047 gain_cnaBRCA15 136 Mitomycin C DNA crosslinker 22 26 2.77258872223978 NA -0.0950132831809029 -0.167552364785726 0.0725390816048231 1.53720613622053 1.44796333134191 0.0487046016355874 0.0471889097341052 0.0500973194794906 0.867217401872706 NA NA NA 0.867923464027958 99.727107917785 a10048 PIK3CA_mut 276 CAY10603 HDAC6 17 32 2.99573227355399 NA 1.14270519887222 1.19298309823201 -0.0502778993597865 1.2306653858828 0.854964335081589 0.0503355069805326 0.0408542402642783 0.0588070136925519 0.867525889276339 NA NA NA 0.881778596091737 99.727107917785 a10049 POLR2B_mut 1241 CHIR-99021 GSK3B 3 43 2.30258509299405 NA 4.32370587516455 4.22505322392804 0.098652651236514 0.949401487659471 0.98676802619798 0.100144778744071 0.103910360915611 0.0999755247609947 0.86758434757492 NA NA NA 0.876245986396405 99.727107917785 a10050 NF1_mut 1042 BIRB 0796 p38, JNK2 4 39 2.30258509299405 NA 4.44097646858466 4.35896674291883 0.0820097256658352 1.24537990245645 0.901924694664255 0.0880537169375715 0.0658511716015932 0.0909274645111737 0.867630877515502 NA NA NA 0.905276009130258 99.727107917785 a10051 gain_cnaBRCA62 1170 CCT018159 HSP90 7 36 2.30258509299405 NA 3.41247859658462 3.32928531847069 0.0831932781139364 1.61291267923577 1.1151768349294 0.069271669547313 0.0515795301165063 0.0746009740412183 0.8676471980926 NA NA NA 0.899737101914676 99.727107917785 a10052 gain_cnaBRCA27_(CLTC,PPM1D) 206 Ruxolitinib JAK1, JAK2, TYK2 9 40 1.65632149833295 0.0237165266173161 4.3370568743777 4.37773125737038 -0.040674382992683 0.51901920360319 0.683111700899085 0.0618079406580051 0.0783677804410878 0.0595427994267247 0.867670339996329 NA NA NA 0.844608043815218 99.727107917785 a10053 ARID1A_mut 201 Epothilone B Microtubules 5 43 -3.44201937618241 NA -4.3646231449139 -4.22077359684972 -0.143849548064187 2.36348134535614 1.75687598159372 0.0791391603446902 0.0608634158872582 0.0818780321270578 0.86771833611909 NA NA NA 0.900703062532665 99.727107917785 a10054 MLL3_mut 1018 ABT-888 PARP1, PARP2 3 42 1.6094379124341 NA 4.46564868680302 4.398606728109 0.0670419586940225 0.699585036996745 0.668052093556053 0.10012962614639 0.0958310357548919 0.100354387540584 0.867723683054676 NA NA NA 0.885431342117681 99.727107917785 a10055 loss_cnaBRCA18 1046 681640 WEE1, CHEK1 12 24 0.693147180559945 NA 2.67636793763085 2.612508356586 0.0638595810448463 1.17484851872558 1.02677672415989 0.0592987636690898 0.0543555871476249 0.062194223478426 0.867795477122708 NA NA NA 0.874379287562573 99.727107917785 a10056 loss_cnaBRCA34 298 OSI-930 KIT, VEGFR, PDGFR 5 43 2.32630161961136 NA 3.97573174464237 3.90611561641896 0.0696161282234113 0.830554789835237 0.88481807693248 0.0790883560097884 0.0838188269761488 0.0786784651425286 0.867802448737468 NA NA NA 0.86692803718595 99.727107917785 a10057 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 260 NG-25 MAP3K7 (TAK1) 7 42 2.32630161961136 NA 3.13256998385433 3.22097230814549 -0.0884023242911662 1.8703796250112 1.18686500512082 0.0682971326351236 0.0472643751616129 0.0744838915207267 0.867857142635902 NA NA NA 0.907133676166679 99.727107917785 a10058 NF1_mut 1373 Dabrafenib BRAF 5 41 2.30258509299405 NA 4.33090912901573 4.20040376598857 0.130505363027155 0.752014949911208 1.71151646156634 0.079212066807773 0.173540915699301 0.0762513045931909 0.867962777341115 NA NA NA 0.767372557474529 99.727107917785 a10059 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 298 OSI-930 KIT, VEGFR, PDGFR 9 39 2.32630161961136 NA 3.95757383990519 3.90316578641231 0.0544080534928768 0.753410974021106 0.904669882041037 0.0618109613982298 0.072215637107713 0.0601413339528073 0.867987059893708 NA NA NA 0.853854637770642 99.727107917785 a10060 TP53_mut 1261 rTRAIL TR10A (DR4), TR10B (DR5) 37 10 -2.30258509299405 NA -0.153835186012473 -0.0916571416137366 -0.0621780443987369 1.06166825437954 0.974895066571193 0.0595067697861637 0.0585663592579352 0.0637792174058522 0.868147758280101 NA NA NA 0.862979186061205 99.727107917785 a10061 loss_cnaBRCA29_(MAP2K4) 303 PIK-93 PI4K, PI3K 7 42 2.99573227355399 NA 2.87508687030152 2.77760058789527 0.0974862824062583 1.06850959211721 1.47778518041308 0.0680739195902574 0.091235757849486 0.0659678305740001 0.868284942706356 NA NA NA 0.837621242241395 99.727107917785 a10062 POLR2B_mut 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 3 43 2.30258509299405 NA 1.5065316412823 1.40666165533197 0.099869985950336 1.54583655782022 0.969306667881712 0.0995981046963148 0.064605786067812 0.103032393420535 0.86830033778858 NA NA NA 0.92170125758775 99.727107917785 a10063 gain_cnaBRCA8_(CHD4,WNK1) 1371 PLX4720 (rescreen) BRAF 3 44 2.30258509299405 NA 4.6173960513986 4.71326675007683 -0.0958706986782261 0.903025132235716 0.96624337950865 0.0995002941359909 0.106166146717167 0.0992200316311381 0.868314832117807 NA NA NA 0.873690014559276 99.727107917785 a10064 gain_cnaBRCA31 171 AKT inhibitor VIII AKT1, AKT2, AKT3 16 31 0.940007258491471 NA 1.93138638957604 1.86660570162761 0.0647806879484292 1.31757568293464 1.23427951476747 0.0513051126162637 0.0491665782751418 0.0524846172794447 0.86837784592726 NA NA NA 0.871537095078784 99.727107917785 a10065 gain_cnaBRCA31 54 CGP-082996 CDK4 3 9 1.63315443905142 NA 2.89881838362645 2.77917754185534 0.119640841771111 0.997838303021462 1.06993269191377 0.113306157418081 0.11990002930218 0.111820904880578 0.868431396045111 NA NA NA 0.8691009158171 99.727107917785 a10066 gain_cnaBRCA62 258 STF-62247 stimulates autophagy 10 39 2.32630161961136 NA 4.58535309117765 4.64250696030634 -0.057153869128685 1.17079748791956 0.913625193966127 0.0590326710693548 0.048816187016462 0.062557238467314 0.86844397966892 NA NA NA 0.888231675748466 99.727107917785 a10067 loss_cnaBRCA20 304 SB52334 ALK5 3 46 2.99573227355399 NA 4.18246574474916 4.30968040019494 -0.127214655445782 1.47451285024578 1.2732435789315 0.0991964369477193 0.0862757184005397 0.0999138401723106 0.868500717501825 NA NA NA 0.896273009252689 99.727107917785 a10068 gain_cnaBRCA31 1259 BMN-673 PARP1 15 31 2.30258509299405 NA 3.36085575274098 3.27877140553964 0.0820843472013428 1.24977359885458 1.69730687171035 0.0523223577799056 0.0656793736694175 0.0483615241117994 0.868639988182429 NA NA NA 0.854321406903383 99.727107917785 a10069 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1502 Bicalutamide ANDR (androgen receptor) 8 37 2.30258509299405 NA 4.58962229708584 4.55153142178421 0.0380908753016245 0.442337821479614 0.612368667051209 0.0647749954148593 0.0861126348504657 0.0622025217015866 0.868833658872175 NA NA NA 0.840773395915885 99.727107917785 a10070 loss_cnaBRCA60 153 Midostaurin KIT 3 44 -0.669430653942629 NA 0.748232556036275 0.602908031039571 0.145324524996704 1.32622899143099 1.47258175067554 0.0991037747416646 0.109577249431035 0.098686897980392 0.868834689791575 NA NA NA 0.869903565799009 99.727107917785 a10071 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1529 MLN4924 NEDD8-activating enzyme 8 29 0 NA 0.458535414775339 0.344575233059906 0.113960181715433 1.50774875843972 1.76377162666966 0.066424828538175 0.0755830048458233 0.0646116424554417 0.868853534331837 NA NA NA 0.858314387063222 99.727107917785 a10072 PIK3CA_mut 1010 Gefitinib EGFR 16 29 -0.693147180559945 NA 1.4348871543044 1.38059335143693 0.0542938028674678 1.1028491950019 1.0202364615075 0.0517185557810662 0.0492304869183627 0.0532168814935741 0.868877892013207 NA NA NA 0.87219430425793 99.727107917785 a10073 POLR2B_mut 238 CAL-101 PI3Kdelta 3 46 2.99573227355399 2.32630161961136 4.80737591689617 4.71319823916262 0.094177677733545 0.308674228097087 0.970960332534219 0.0989044825861547 0.305103792804897 0.0969943617446658 0.86888412515656 NA NA NA 0.69643886342192 99.727107917785 a10074 loss_cnaBRCA34 1230 IOX2 EGLN1 5 42 -2.30258509299405 NA 0.295668613791403 0.243962009751887 0.0517066040395165 0.28460244841384 0.684319631637879 0.0784996335027484 0.181680109667679 0.0755591417357994 0.868954278989892 NA NA NA 0.760441521214269 99.727107917785 a10075 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1527 GDC0941 (rescreen) PI3K 18 27 1.38629436111989 NA 0.945360468867819 1.00418608969415 -0.0588256208263264 1.14878048891113 1.17569725739137 0.0504884581801732 0.0512070159566206 0.0500346670509789 0.868996021582119 NA NA NA 0.868501585735654 99.727107917785 a10076 ARID1A_mut 186 Bexarotene Retinioic acid X family agonist 5 42 2.07944154167984 NA 3.52389229644774 3.61399036291727 -0.0900980664695323 0.985515277204966 1.16330764712348 0.07844035387332 0.0914222930415251 0.0774499047541881 0.869052315664526 NA NA NA 0.856722082026779 99.727107917785 a10077 POLR2B_mut 1016 Temsirolimus MTOR 3 41 -1.6094379124341 NA -1.61132478991202 -1.76115677637406 0.149831986462045 1.9229551330891 1.48680034430717 0.0991983493370415 0.0779175675416563 0.100774785959486 0.869066254563023 NA NA NA 0.906109405167037 99.727107917785 a10078 NF1_mut 288 KIN001-055 JAK3, MNK1 5 44 2.32630161961136 NA 4.27857438604619 4.34587433094102 -0.0672999448948337 0.749724106275692 0.871003787778319 0.078133354506186 0.0897662811312697 0.0772671093273849 0.869215014307093 NA NA NA 0.858671514448166 99.727107917785 a10079 gain_cnaBRCA31 1008 Methotrexate Dihydrofolate reductase (DHFR) 14 31 -1.6094379124341 NA 0.642303580678293 0.700871071635087 -0.0585674909567943 1.40310162146874 0.93553089172973 0.0533357352079386 0.0417414462791989 0.0626034815894824 0.869219086400125 NA NA NA 0.888209990143539 99.727107917785 a10080 gain_cnaBRCA47_(EGFR) 1248 FK866 NAMPT 5 39 0 NA -0.460056578199068 -0.675148087310602 0.215091509111534 2.22128390015351 2.78417751669683 0.0786278649419552 0.0968320659491882 0.0772549551246722 0.869323819287152 NA NA NA 0.850202263750948 99.727107917785 a10081 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 302 PI-103 PI3Ka, PRKDC (DNAPK) 6 42 2.32630161961136 NA 1.24632779297169 1.11159106889518 0.13473672407651 0.792458189757576 1.95863488080916 0.0721484854098172 0.170023763799738 0.0687911388675195 0.86942205092223 NA NA NA 0.764783750715998 99.727107917785 a10082 gain_cnaBRCA8_(CHD4,WNK1) 184 BMS-754807 IGF1R 3 45 0.940007258491471 NA 1.78306773968757 1.61645570234603 0.166612037341536 2.02546340831421 1.67403045058018 0.0985386269793155 0.0822587249207367 0.0995274830776183 0.869467945705227 NA NA NA 0.900973981448514 99.727107917785 a10083 loss_cnaBRCA57 1009 ATRA Retinoic acid and retinoid X receptor agonist 5 40 2.30258509299405 NA 4.02472655436015 4.11612641123902 -0.0913998568788772 1.42448766051759 1.13660534591889 0.0783615617678737 0.0641633194952823 0.0804147694774259 0.869560255247249 NA NA NA 0.895941313863079 99.727107917785 a10084 gain_cnaBRCA63 231 FMK RSK 7 42 2.99573227355399 2.32630161961136 5.62375463714623 5.58347554073771 0.0402790964085193 1.20254273604272 0.444769039887032 0.0673967294520928 0.0334949396817847 0.0905618260181732 0.869583057905723 NA NA NA 0.932903270588998 99.727107917785 a10085 gain_cnaBRCA9_(KRAS) 1371 PLX4720 (rescreen) BRAF 4 43 2.30258509299405 NA 4.78323773350187 4.70006916798997 0.0831685655118957 0.516916242234434 0.987731062305581 0.0863167505913957 0.160893697501919 0.0842016300649308 0.869585894439107 NA NA NA 0.791444317529329 99.727107917785 a10086 loss_cnaBRCA38 292 Masitinib KIT 4 44 2.99573227355399 NA 3.92359537720513 4.0182121090436 -0.0946167318384772 0.868813458829914 1.11166012480585 0.0862141662239869 0.108903391029305 0.0851130032706732 0.869598434400796 NA NA NA 0.84900156361646 99.727107917785 a10087 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 261 TL-1-85 MAP3K7 (TAK1) 7 42 2.32630161961136 NA 4.09529091249458 4.01305905818406 0.0822318543105256 1.79175841818196 1.11266930833147 0.0673709322947614 0.045894498653431 0.0739050261338103 0.869632516033244 NA NA NA 0.909708765152293 99.727107917785 a10088 ASH1L_mut 257 NPK76-II-72-1 PLK3 3 46 2.32630161961136 NA 3.33172029245614 3.48856290606491 -0.156842613608778 1.7219557995413 1.59020219899637 0.0982704476877495 0.0910839951005465 0.0986306104392045 0.869716877908482 NA NA NA 0.890761770328853 99.727107917785 a10089 loss_cnaBRCA38 1243 piperlongumine Increases ROS levels 3 44 2.30258509299405 NA 1.78946019387226 1.70484628486981 0.0846139090024551 0.597573334459199 0.870193431341164 0.0983980794948523 0.141595857986251 0.0972357477716719 0.869760038030913 NA NA NA 0.835400743823163 99.727107917785 a10090 loss_cnaBRCA22_(SYNCRIP,ZNF292) 104 Bortezomib Proteasome 4 10 -3.91202300542815 NA -4.70037278604503 -4.52045116474848 -0.179921621296548 2.61764275477592 1.45519500668543 0.0990254731236237 0.0687342155335287 0.123640900683383 0.869855875698622 NA NA NA 0.903439454835196 99.727107917785 a10091 gain_cnaBRCA31 274 PXD101, Belinostat HDAC 16 32 2.99573227355399 NA 0.722162844217144 0.646173596840229 0.0759892473769156 1.88919339311888 1.2811420138038 0.0504365966875847 0.0402231172592999 0.0593136799497332 0.86988199513631 NA NA NA 0.885964777952674 99.727107917785 a10092 gain_cnaBRCA62 230 GSK429286A ROCK2 10 39 2.99573227355399 2.32630161961136 5.36356528544648 5.41625699641779 -0.0526917109713105 1.35336563509445 0.75874319753784 0.0583241245309821 0.0389338325172069 0.0694460406924211 0.870008412904546 NA NA NA 0.907956331916662 99.727107917785 a10093 ASH1L_mut 306 TG101348 JAK2 3 45 2.32630161961136 NA 3.10624670414514 3.23279841349125 -0.126551709346114 1.34388638148218 1.29011598587288 0.0979123215233259 0.0941684587997237 0.0980932805514304 0.870289986993669 NA NA NA 0.887282893950033 99.727107917785 a10094 loss_cnaBRCA17 172 Embelin XIAP 11 37 3.46573590279973 NA 2.95069053689589 3.00565915471303 -0.054968617817146 0.902259119109429 0.994085727905271 0.0563861957501033 0.0609233164319831 0.0552956513448548 0.870300117358665 NA NA NA 0.864434293231516 99.727107917785 a10095 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 150 Bicalutamide ANDR (androgen receptor) 15 33 0.0237165266173161 NA 2.78461054933853 2.75257737714097 0.0320331721975604 0.482482163219933 0.681969934210316 0.0510081822147834 0.066392448549354 0.0469715314277792 0.870603835127454 NA NA NA 0.853332272649972 99.727107917785 a10096 gain_cnaBRCA15 1067 CCT007093 PPM1D 22 24 1.88706964903238 NA 4.0605832716568 4.10860143013493 -0.048018158478131 1.16177398507343 0.809085416997142 0.0483487544525714 0.0413317556556373 0.059348688617262 0.870635908353532 NA NA NA 0.872734968546882 99.727107917785 a10097 loss_cnaBRCA60 260 NG-25 MAP3K7 (TAK1) 3 46 2.32630161961136 NA 3.08994718293829 3.21606489739731 -0.126117714459012 0.740706287223906 1.3135982172868 0.0974336795313528 0.170266834012829 0.0960093526310539 0.870816132320792 NA NA NA 0.806179984614432 99.727107917785 a10098 loss_cnaBRCA34 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 5 42 2.32630161961136 NA 1.52357758376763 1.4042408823049 0.119336701462724 1.26570362198978 1.56864045452123 0.0772845402668817 0.0942848700038629 0.0760765165266296 0.870964214594537 NA NA NA 0.85315904841241 99.727107917785 a10099 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1194 SB-505124 TGFR1 (ALK5) 6 41 2.30258509299405 NA 4.33140904174537 4.39742690107426 -0.0660178593288974 1.55239807878237 0.813112780557767 0.0713774535177303 0.04252637273339 0.081191515995618 0.871015337929799 NA NA NA 0.922327318212895 99.727107917785 a10100 ARID1A_mut 235 QL-XII-47 BTK, BMX 5 44 2.32630161961136 NA 1.81276879874807 1.69617808301068 0.116590715737387 1.33863360598066 1.53027977530667 0.0769619555493202 0.0870968091765291 0.0761891502578486 0.871157966785691 NA NA NA 0.862586762825084 99.727107917785 a10101 loss_cnaBRCA29_(MAP2K4) 135 Gemcitabine DNA replication 7 40 0.0237165266173161 NA -0.433502167334103 -0.247525003154801 -0.185977164179302 3.01333076970098 2.74700607005936 0.066802419493827 0.0617181379652382 0.0677017667366435 0.871208673809537 NA NA NA 0.882585427333897 99.727107917785 a10102 gain_cnaBRCA48 133 Doxorubicin DNA intercalating 5 43 0.0237165266173161 NA -0.903084639595898 -1.04547758166627 0.142392942070376 2.21987406358628 1.80918116397612 0.0770308092092561 0.0641446036989754 0.0787057398704243 0.871210250505524 NA NA NA 0.895882734542529 99.727107917785 a10103 gain_cnaBRCA64_(SDHC) 1018 ABT-888 PARP1, PARP2 9 36 1.6094379124341 NA 4.43561414382938 4.39494170407007 0.0406724397593141 1.05919494163783 0.542544244610736 0.060744719186783 0.0383993901032253 0.0749661251839392 0.871285851549198 NA NA NA 0.913572824868834 99.727107917785 a10104 gain_cnaBRCA27_(CLTC,PPM1D) 1039 SL 0101-1 RSK, AURKB, PIM3 10 33 2.30258509299405 NA 4.69269168379347 4.63553644259896 0.0571552411945175 1.02766841561485 0.955986414171523 0.05879114259456 0.0556164228909595 0.0597866667844327 0.871422808631515 NA NA NA 0.877829511535076 99.727107917785 a10105 gain_cnaBRCA58_(CCND1) 154 CHIR-99021 GSK3B 9 38 0.940007258491471 NA 3.31992529241676 3.26490012508666 0.0550251673301005 0.712155033242519 0.950567127940996 0.060285331050515 0.0772657142919639 0.0578866717696092 0.871545173189487 NA NA NA 0.848386663924364 99.727107917785 a10106 gain_cnaBRCA12_(TERT) 157 JNK-9L JNK 9 38 1.63315443905142 NA 0.107606277916233 0.0435848814888575 0.0640213964273756 0.921957762876988 1.0918442949604 0.0601915699062667 0.069440704341591 0.0586360131411389 0.871743168636155 NA NA NA 0.859378303911601 99.727107917785 a10107 loss_cnaBRCA38 344 THZ-2-49 CDK9 4 45 2.99573227355399 NA 1.66983612307072 1.79553622846899 -0.125700105398276 1.14277332478471 1.50483133007703 0.0846829099346176 0.10999565939462 0.08353102629239 0.871760856725349 NA NA NA 0.84777048871021 99.727107917785 a10108 loss_cnaBRCA23 192 LFM-A13 BTK 3 45 2.77258872223978 NA 4.71900190646712 4.80056800544834 -0.081566098981213 1.3844236892195 0.809704265065714 0.0967706634081427 0.0589170061277975 0.100735666712331 0.871788813177756 NA NA NA 0.92847018861506 99.727107917785 a10109 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 295 NVP-BHG712 EPHB4 15 34 2.32630161961136 NA 3.92985727245471 3.86767191988972 0.0621853525649856 0.93078376214347 1.34700557870607 0.050240698662312 0.066809666320114 0.0461656236232672 0.871933772940068 NA NA NA 0.853007528894076 99.727107917785 a10110 loss_cnaBRCA36_(FAT1,IRF2) 231 FMK RSK 9 40 2.99573227355399 2.32630161961136 5.61830950864384 5.58268673983032 0.0356227688135178 0.252852119362606 0.646017214058683 0.0596048301738942 0.140883805535489 0.0551421355937458 0.872344636855302 NA NA NA 0.789567498717411 99.727107917785 a10111 CDH1_mut 235 QL-XII-47 BTK, BMX 4 45 2.32630161961136 NA 1.59088048174912 1.71849239376031 -0.127611912011197 1.3748368608854 1.52400456779845 0.0842366148773975 0.0928196760225167 0.0837345994280996 0.872430711638801 NA NA NA 0.869337170406746 99.727107917785 a10112 loss_cnaBRCA60 211 TL-2-105 CRAF 3 46 2.32630161961136 1.63315443905142 4.00643501434608 3.901104957531 0.105330056815077 0.654959635275144 1.11163802071902 0.0960963636213797 0.160819157612406 0.0947521179124014 0.872573485641592 NA NA NA 0.81579056736161 99.727107917785 a10113 loss_cnaBRCA34 1046 681640 WEE1, CHEK1 3 33 0.693147180559945 NA 2.53767971802831 2.64253262592573 -0.104852907897429 0.970406533327828 1.08325597788417 0.0973614176703687 0.108050496669531 0.0967942111911804 0.872690158782157 NA NA NA 0.87269721729101 99.727107917785 a10114 loss_cnaBRCA28_(GPS2) 1230 IOX2 EGLN1 4 43 -2.30258509299405 NA 0.300210439674538 0.244741993484607 0.0554684461899305 0.505245482247874 0.668311466300825 0.0842092855618083 0.109785140370078 0.0829978969191628 0.87274161984211 NA NA NA 0.848474064196382 99.727107917785 a10115 gain_cnaBRCA8_(CHD4,WNK1) 1072 BMS-708163 g-secretase 3 43 1.6094379124341 NA 3.77072398576165 3.67821668401528 0.0925073017463705 0.616018685804953 0.975645317568344 0.0961395509527667 0.150169635886111 0.0948165281794532 0.872832641896812 NA NA NA 0.827085377256846 99.727107917785 a10116 gain_cnaBRCA27_(CLTC,PPM1D) 1164 XMD8-92 MAP2K5 (ERK5) 7 19 2.30258509299405 NA 3.8155030940919 3.90990484193519 -0.0944017478432948 1.39512428272301 1.29460930990751 0.0714918022173312 0.0676654754077113 0.0729191016323213 0.87289993408733 NA NA NA 0.879126712321985 99.727107917785 a10117 gain_cnaBRCA48 192 LFM-A13 BTK 5 43 2.77258872223978 NA 4.738159141497 4.80213419202538 -0.0639750505283772 1.11352935527892 0.812420993110115 0.0759000642945465 0.0574525047095437 0.0787461809467374 0.873084097575002 NA NA NA 0.906151184197178 99.727107917785 a10118 loss_cnaBRCA36_(FAT1,IRF2) 1262 UNC1215 LMBL3 9 37 0 NA 2.72878452878108 2.76451009442902 -0.0357255656479416 0.280970561118108 0.648307673659139 0.0596888872279424 0.127150565190081 0.0551058812034439 0.873146107444066 NA NA NA 0.802878667119819 99.727107917785 a10119 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 328 SNX-2112 HSP90 7 41 0.940007258491471 NA 0.532458934633996 0.397568423951534 0.134890510682462 2.30918797404758 2.0138396009529 0.0656474270183715 0.0584146947751609 0.066981754961336 0.873171757578025 NA NA NA 0.888158506453876 99.727107917785 a10120 loss_cnaBRCA18 1018 ABT-888 PARP1, PARP2 14 31 1.6094379124341 NA 4.42692632838632 4.39230516269608 0.0346211656902398 0.670008511034457 0.669379131415059 0.0517066072615262 0.0516727252267088 0.0517213101894154 0.873178210992983 NA NA NA 0.873754648416095 99.727107917785 a10121 loss_cnaBRCA34 201 Epothilone B Microtubules 5 43 -3.44201937618241 NA -4.35920179005708 -4.22140398694935 -0.137797803107733 2.063604302623 1.79254883028916 0.0758078748964065 0.0667753032558527 0.0768725519658534 0.873236904518716 NA NA NA 0.89205771223356 99.727107917785 a10122 gain_cnaBRCA13_(FGFR1,WHSC1L1) 203 BMS-345541 IKBKB 11 38 2.77258872223978 NA 3.48908882865511 3.54484994766387 -0.0557611190087615 1.17324819504448 0.968343310904591 0.054914939239543 0.0475271295914053 0.0575840390291656 0.873260285451065 NA NA NA 0.887476679355862 99.727107917785 a10123 ARID1A_mut 1039 SL 0101-1 RSK, AURKB, PIM3 4 39 2.30258509299405 NA 4.57470546565003 4.6564307072077 -0.0817252415576695 1.30834496206674 0.94054270233561 0.0840634768432637 0.0624645975848538 0.0868915801002173 0.873575762597746 NA NA NA 0.910091797004593 99.727107917785 a10124 gain_cnaBRCA8_(CHD4,WNK1) 328 SNX-2112 HSP90 4 44 0.940007258491471 NA 0.260072119170941 0.431527941994707 -0.171455822823765 2.3917753216274 2.0291785990133 0.0834425228151839 0.0716855890573802 0.0844951858388102 0.873753714080365 NA NA NA 0.897348331735676 99.727107917785 a10125 gain_cnaBRCA30_(CRNKL1,FOXA2) 310 YM201636 FYV1 5 44 1.63315443905142 NA 2.34533312723407 2.42254638795459 -0.077213260720522 0.73761635539342 1.04696225725875 0.0753830596107618 0.104679431463174 0.0737498034768597 0.873778086415899 NA NA NA 0.839749385009732 99.727107917785 a10126 loss_cnaBRCA29_(MAP2K4) 269 NSC-207895 MDM4 7 42 2.99573227355399 NA 4.67081204147492 4.592797459165 0.0780145823099234 0.884511060492804 1.23549527337047 0.0652058265215136 0.0882007990566649 0.0631443794172493 0.873785298307112 NA NA NA 0.843278421649087 99.727107917785 a10127 ASH1L_mut 202 GSK-1904529A IGF1R 3 45 0.0237165266173161 NA 2.11476371277828 2.1946684723776 -0.0799047595993208 0.296510134814594 0.855464313236145 0.0952446889803664 0.269484075643096 0.0934051349226342 0.873792930958009 NA NA NA 0.724232150515631 99.727107917785 a10128 gain_cnaBRCA31 1011 ABT-263 BCL2, BCL2L1, BCL2L2 13 30 0.693147180559945 NA 1.74430819506385 1.65492384650257 0.0893843485612811 1.63904878289849 1.70342236047007 0.0530522571532021 0.0545342820139947 0.0524733915883404 0.873844849081413 NA NA NA 0.872458182030126 99.727107917785 a10129 loss_cnaBRCA34 1050 ZM-447439 AURKB 4 35 1.38629436111989 0.693147180559945 2.78733816109446 2.89941961532646 -0.112081454232005 1.08404458650764 1.34847731548078 0.0843352849337144 0.103391922829564 0.0831170483517133 0.873918104388599 NA NA NA 0.857804287137492 99.727107917785 a10130 gain_cnaBRCA62 1502 Bicalutamide ANDR (androgen receptor) 7 38 2.30258509299405 NA 4.590906636598 4.55229722438202 0.0386094122159877 1.10990298340633 0.449591329772768 0.0656551709130063 0.034786294652073 0.0858766832436506 0.873923192692578 NA NA NA 0.930536064825786 99.727107917785 a10131 loss_cnaBRCA20 229 LY317615 PRKCB (PKCbeta) 3 46 2.99573227355399 2.32630161961136 3.21356317309419 3.36804089149987 -0.154477718405675 0.703086210665784 1.65453163867996 0.0950380755355727 0.219713764915675 0.0933664336143626 0.873964631995003 NA NA NA 0.761962008618279 99.727107917785 a10132 loss_cnaBRCA29_(MAP2K4) 283 GSK2126458 PI3K, MTOR 7 41 -2.05572501506252 0.0237165266173161 -2.96375699077457 -3.07099708431507 0.107240093540494 0.89310179850824 1.73090754010007 0.0651522315158583 0.120076002220149 0.0619559919037006 0.874120185949788 NA NA NA 0.807465786702757 99.727107917785 a10133 gain_cnaBRCA10_(MDM2,NUP107) 1022 AZD7762 CHEK1, CHEK2 3 42 0.693147180559945 NA 0.759384497329613 0.915133984781903 -0.15574948745229 1.79335555004472 1.62730991658497 0.0952359274111957 0.0868480806543946 0.0957097882001126 0.874131287236475 NA NA NA 0.895878692795332 99.727107917785 a10134 gain_cnaBRCA58_(CCND1) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 8 34 -1.38629436111989 0.693147180559945 -0.388961366571899 -0.281832357575773 -0.107129008996125 1.05515074336533 1.81892573503258 0.0626459727071023 0.101529577332662 0.058896857047441 0.874137330320751 NA NA NA 0.828075413655427 99.727107917785 a10135 loss_cnaBRCA18 1114 Cetuximab EGFR 14 31 4.18661983833127 NA 6.25136854852453 6.29668283231113 -0.0453142837866034 0.965612011353279 0.847080357322591 0.0512261891518624 0.0469280448604783 0.0534946695374103 0.87434636114796 NA NA NA 0.88112243360661 99.727107917785 a10136 TP53_mut 202 GSK-1904529A IGF1R 38 10 0.0237165266173161 NA 2.17979715157528 2.22720806354663 -0.0474109119713515 0.907740109055868 0.45805569214663 0.0565126067748075 0.0522296101035605 0.103504689024091 0.874359357538717 NA NA NA 0.820038702927831 99.727107917785 a10137 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 52 GNF-2 ABL [T315I] 3 9 0.246860077931526 NA 2.53416740746183 2.47106125962704 0.0631061478347834 0.719406903078002 0.545924590594088 0.107919304878072 0.087719686264869 0.115594990447508 0.87462522273548 NA NA NA 0.898671533471865 99.727107917785 a10138 gain_cnaBRCA27_(CLTC,PPM1D) 52 GNF-2 ABL [T315I] 3 9 0.246860077931526 NA 2.53416740746183 2.47106125962704 0.0631061478347834 0.719406903078002 0.545924590594088 0.107919304878072 0.087719686264869 0.115594990447508 0.87462522273548 NA NA NA 0.898671533471865 99.727107917785 a10139 gain_cnaBRCA30_(CRNKL1,FOXA2) 205 BMS-708163 g-secretase 5 43 2.32630161961136 0.940007258491471 4.94243440787423 4.89119173968304 0.0512426681911862 0.774500131411308 0.674730644051597 0.0749179110292912 0.0661622459609024 0.0759453696714975 0.874712299077745 NA NA NA 0.893060420610209 99.727107917785 a10140 loss_cnaBRCA20 135 Gemcitabine DNA replication 3 44 0.0237165266173161 NA -0.0286313839866459 -0.292036844217519 0.263405460230873 1.62402772150376 2.82642384536959 0.094612904838329 0.16219271182574 0.0931938996560613 0.874726491834018 NA NA NA 0.815170912396441 99.727107917785 a10141 loss_cnaBRCA29_(MAP2K4) 1502 Bicalutamide ANDR (androgen receptor) 7 38 2.30258509299405 NA 4.52598148863811 4.56425712005884 -0.0382756314207322 0.565834858861696 0.591592957824372 0.0650872458476569 0.0676445270581813 0.0646992681614969 0.875004451650095 NA NA NA 0.874065634649669 99.727107917785 a10142 gain_cnaBRCA19 1502 Bicalutamide ANDR (androgen receptor) 4 41 2.30258509299405 NA 4.60269843731865 4.55397188374215 0.0487265535765067 0.768529304628376 0.572242345386946 0.0828588924048628 0.0634023364926449 0.0851502059735865 0.875054570343761 NA NA NA 0.908783864854599 99.727107917785 a10143 BRCA1_mut 1011 ABT-263 BCL2, BCL2L1, BCL2L2 4 39 0.693147180559945 NA 1.80874058001212 1.66894255412458 0.139798025887538 0.928297055816773 1.73054532474631 0.0829737105612135 0.150596218108798 0.0807826434179249 0.87520066073581 NA NA NA 0.805397939858303 99.727107917785 a10144 loss_cnaBRCA24 263 FR-180204 ERK 3 46 2.99573227355399 NA 5.42292495724908 5.35364314581238 0.069281811436702 0.74551286904099 0.738071700444241 0.0938282253322208 0.0929317444591191 0.0938686734567952 0.875555503139596 NA NA NA 0.888820294550454 99.727107917785 a10145 gain_cnaBRCA8_(CHD4,WNK1) 196 Phenformin AAPK1 (AMPK) agonist 4 44 8.29404964010203 NA 7.33935690637262 7.18952728202116 0.149829624351458 2.64082159527188 1.75378725269778 0.082106151317335 0.0567359887618735 0.0854320409279866 0.875758511062804 NA NA NA 0.917937372913887 99.727107917785 a10146 loss_cnaBRCA7_(FAS,PTEN) 268 YM155 BIRC5 (Survivin) 4 45 1.63315443905142 NA -3.47449811511879 -3.60634065858641 0.131842543467624 2.13168332637471 1.56781859910608 0.0819039151413087 0.0618490288104119 0.0840929834247381 0.875933441929958 NA NA NA 0.910825616827065 99.727107917785 a10147 MLL3_mut 1053 MK-2206 AKT1, AKT2 3 39 1.38629436111989 0.693147180559945 1.24890538715349 1.40503087328265 -0.156125486129157 1.32272342062764 1.67442110209748 0.0941304124812643 0.118033357309931 0.0932414706990883 0.875950105254814 NA NA NA 0.86150092244167 99.727107917785 a10148 PTEN_mut 302 PI-103 PI3Ka, PRKDC (DNAPK) 9 39 2.32630161961136 NA 1.21648352868276 1.1081138434175 0.108369685265262 2.01343555197112 1.83535650551858 0.0580278236113465 0.0538232699622144 0.0590455777607316 0.875997195046094 NA NA NA 0.88502569761047 99.727107917785 a10149 loss_cnaBRCA36_(FAT1,IRF2) 258 STF-62247 stimulates autophagy 9 40 2.32630161961136 NA 4.58510718964969 4.64113344142191 -0.0560262517722165 0.624844616162166 1.02451251520852 0.0578660567082267 0.0896642946470968 0.0546857660990249 0.876037018683647 NA NA NA 0.834088571446935 99.727107917785 a10150 loss_cnaBRCA28_(GPS2) 229 LY317615 PRKCB (PKCbeta) 4 45 2.99573227355399 2.32630161961136 3.23648741258215 3.36943601950995 -0.132948606927801 0.220191274558419 1.67895975327906 0.0817921446644432 0.603786899342047 0.0791851065328686 0.876101337579198 NA NA NA 0.629429470002479 99.727107917785 a10151 loss_cnaBRCA38 1052 RO-3306 CDK1 3 40 1.6094379124341 NA 3.6311141599835 3.51776530070262 0.113348859280879 0.798941351364252 1.22850354692808 0.093592484275861 0.141873817254955 0.092265797330673 0.876524628998668 NA NA NA 0.83651587162456 99.727107917785 a10152 gain_cnaBRCA58_(CCND1) 1046 681640 WEE1, CHEK1 6 30 0.693147180559945 NA 2.69658313624385 2.62123723307237 0.0753459031714834 1.1572594838766 1.06251444434519 0.0699609780300912 0.0651071814240733 0.0709128271831804 0.876613395358418 NA NA NA 0.886997571774716 99.727107917785 a10153 gain_cnaBRCA13_(FGFR1,WHSC1L1) 293 MP470 PDGFR 11 37 2.99573227355399 NA 3.60107331698409 3.51092653880546 0.0901467781786391 1.05643235421862 1.8177690895135 0.0536001353977895 0.0853313303200711 0.0495919854170067 0.87665427637608 NA NA NA 0.837919085646832 99.727107917785 a10154 loss_cnaBRCA7_(FAS,PTEN) 1010 Gefitinib EGFR 4 41 -0.693147180559945 NA 1.32168202275634 1.40752862364673 -0.085846600890386 0.986401758199609 1.05443616680134 0.0817716995199669 0.0870300566445402 0.0814146968714131 0.876680314260104 NA NA NA 0.877481670712421 99.727107917785 a10155 gain_cnaBRCA12_(TERT) 1218 JQ1 BRD2, BRD3, BRD4 10 36 0 NA 2.42711290687638 2.46655658454369 -0.0394436776673111 0.815756879840343 0.676787010283821 0.0557557411752273 0.0483522464132093 0.0582807841580318 0.876764199855843 NA NA NA 0.890790096366175 99.727107917785 a10156 gain_cnaBRCA27_(CLTC,PPM1D) 1061 SB590885 BRAF 10 32 1.6094379124341 NA 4.05915084092061 3.99714946375674 0.0620013771638623 0.824095904351881 1.16439026802725 0.0565156310571742 0.0752356331786699 0.0532479348774594 0.876819271574484 NA NA NA 0.853659407505173 99.727107917785 a10157 gain_cnaBRCA14_(RAD21) 1069 EHT 1864 Rac GTPases 21 25 2.30258509299405 NA 3.53979742550459 3.57958607721149 -0.0397886517069033 0.855278033291628 0.873630141682264 0.0459805527144714 0.0465213067074486 0.0455440463973532 0.877266083893836 NA NA NA 0.877053665300504 99.727107917785 a10158 NF1_mut 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 5 43 2.77258872223978 NA -0.529735159349188 -0.425689066909293 -0.104046092439895 1.32479058328881 1.42675026742796 0.0733661749125526 0.078537765706033 0.0729252307255301 0.877285862236757 NA NA NA 0.875345997578449 99.727107917785 a10159 BRCA2_mut 171 AKT inhibitor VIII AKT1, AKT2, AKT3 6 41 0.940007258491471 NA 1.96339589049466 1.87772155221231 0.085674338282349 0.957008775841741 1.29585881122314 0.0678497242023716 0.0895230435133615 0.0661139450844048 0.877336713469623 NA NA NA 0.850488133215076 99.727107917785 a10160 loss_cnaBRCA18 1003 Camptothecin TOP1 14 31 -2.30258509299405 NA -2.58440891415445 -2.50438516719873 -0.0800237469557246 1.74295966725717 1.53527280742168 0.0499865401181046 0.0459125638183326 0.052123470544701 0.877361906281578 NA NA NA 0.883792686760572 99.727107917785 a10161 gain_cnaBRCA14_(RAD21) 1019 Bosutinib SRC, ABL, TEC 20 25 0.693147180559945 NA 2.63824463232874 2.68208166129497 -0.0438370289662311 0.903192314055177 0.970601296369016 0.0465652245553707 0.0485356532424533 0.0451648160065557 0.877376255925676 NA NA NA 0.876396830582146 99.727107917785 a10162 gain_cnaBRCA15 1259 BMN-673 PARP1 22 24 2.30258509299405 NA 3.34302581849726 3.27117424399598 0.0718515745012813 1.25020790967721 1.81153347914688 0.0457978928374597 0.0574717004628715 0.0396633986224307 0.877403736694317 NA NA NA 0.875524148582548 99.727107917785 a10163 loss_cnaBRCA24 1129 PF-4708671 RPS6KB1 (p70S6KA) 3 40 2.30258509299405 NA 3.90873161944236 3.80148457113927 0.107247048303088 0.454429959581759 1.17906210122952 0.0929095574214685 0.236003472134176 0.0909596264617886 0.877418194227647 NA NA NA 0.75402070218433 99.727107917785 a10164 loss_cnaBRCA24 208 SB-715992 KIF11 3 46 -2.05572501506252 NA -1.38912020300199 -1.23016748447345 -0.15895271852854 0.561323161859084 1.75411682116839 0.0923987464565083 0.2831750573094 0.090616951283019 0.877435839802186 NA NA NA 0.716449732033042 99.727107917785 a10165 loss_cnaBRCA57 1020 Lenalidomide TNFA 5 40 1.6094379124341 NA 4.20792370282519 4.26057693614151 -0.0526532333163194 0.814255707409985 0.704990469598473 0.073552563729269 0.0646642483892447 0.0746864469619115 0.877497703464983 NA NA NA 0.895668166531167 99.727107917785 a10166 gain_cnaBRCA15 275 I-BET BRD2, BRD3, BRD4 22 27 2.99573227355399 NA 4.00536243975191 4.06630141602649 -0.060938976274584 1.54160573571136 1.21181860232751 0.0445127233857866 0.0395295469281997 0.0502872097833288 0.877499708972218 NA NA NA 0.880580776965005 99.727107917785 a10167 loss_cnaBRCA42 301 PHA-793887 CDK-pan 3 45 2.32630161961136 NA 2.77909854650039 2.93181466345635 -0.152716116955959 0.541912798977506 1.6869800856988 0.0923445679143015 0.281809393031696 0.0905263306014062 0.877604061004314 NA NA NA 0.718339381228659 99.727107917785 a10168 gain_cnaBRCA30_(CRNKL1,FOXA2) 203 BMS-345541 IKBKB 5 44 2.77258872223978 NA 3.59889438385777 3.52476825470782 0.0741261291499451 0.855655746061173 1.02903053160534 0.072999862162633 0.0866307852090853 0.0720349172092151 0.87773561276511 NA NA NA 0.864061847947701 99.727107917785 a10169 loss_cnaBRCA57 1022 AZD7762 CHEK1, CHEK2 5 40 0.693147180559945 NA 1.01144598039476 0.891413773771375 0.120032206623381 1.37897136072651 1.65949890584708 0.0733946897047459 0.0870447422201299 0.0723303921445561 0.877758501971795 NA NA NA 0.864204520935504 99.727107917785 a10170 loss_cnaBRCA29_(MAP2K4) 254 AC220 FLT3 7 41 0.0237165266173161 NA 2.17575219871842 2.23195867499128 -0.0562064762728589 0.538985502810401 0.931012401083875 0.0631725954584043 0.104281981574244 0.0603713508084575 0.87791355739772 NA NA NA 0.825762669774753 99.727107917785 a10171 loss_cnaBRCA36_(FAT1,IRF2) 205 BMS-708163 g-secretase 9 39 2.32630161961136 0.940007258491471 4.86479319320614 4.90385328479197 -0.0390600915858261 0.626654109840502 0.695463197099889 0.0571059128741224 0.0623311823419906 0.0561641388770943 0.877951203760074 NA NA NA 0.871481033988442 99.727107917785 a10172 loss_cnaBRCA38 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 42 2.30258509299405 NA 3.06389299997165 3.18493654809335 -0.121043548121702 0.620366056438149 1.33713069433331 0.0922235638416003 0.195116329891866 0.0905248444558768 0.878079831921821 NA NA NA 0.786042805637964 99.727107917785 a10173 gain_cnaBRCA13_(FGFR1,WHSC1L1) 257 NPK76-II-72-1 PLK3 11 38 2.32630161961136 NA 3.41368852737678 3.49785475671605 -0.0841662293392642 2.18303766303435 1.39570785819111 0.0527327820108416 0.0385546391454722 0.0603036150046091 0.87825518104751 NA NA NA 0.905684625488632 99.727107917785 a10174 loss_cnaBRCA7_(FAS,PTEN) 166 FTI-277 Farnesyl transferase (FNTA) 4 43 0.0237165266173161 NA 2.30481895624214 2.23876642402514 0.0660525322169994 0.468755047772863 0.840693118826378 0.0804385394003941 0.140910551322757 0.0785691362731859 0.878393141148889 NA NA NA 0.814487802189956 99.727107917785 a10175 NF1_mut 1248 FK866 NAMPT 5 39 0 NA -0.473581744421975 -0.673414091640999 0.199832347219024 2.29452657249111 2.77805094660632 0.0730465351457763 0.0870908838515087 0.0719325710938237 0.878522309232299 NA NA NA 0.864454857064515 99.727107917785 a10176 gain_cnaBRCA12_(TERT) 167 OSU-03012 PDPK1 (PDK1) 9 39 2.77258872223978 NA 2.19292654984774 2.26068344552352 -0.0677568956757804 0.992578279692564 1.23073605202175 0.0568078538253036 0.0682635284914425 0.055053961866539 0.878583110973743 NA NA NA 0.862804853510481 99.727107917785 a10177 gain_cnaBRCA8_(CHD4,WNK1) 230 GSK429286A ROCK2 4 45 2.99573227355399 2.32630161961136 5.47197666632686 5.39959486776558 0.0723817985612802 1.2778835098171 0.872099705553533 0.0801159806491345 0.0566419380211267 0.0829971597288163 0.878619867818179 NA NA NA 0.91810850405083 99.727107917785 a10178 loss_cnaBRCA20 298 OSI-930 KIT, VEGFR, PDGFR 3 45 2.32630161961136 NA 3.83783182784564 3.91840299434867 -0.0805711665030273 0.727401943805021 0.886597620680317 0.0915295475757091 0.110765673901779 0.0908768133634312 0.878675633733675 NA NA NA 0.869042345257924 99.727107917785 a10179 gain_cnaBRCA8_(CHD4,WNK1) 258 STF-62247 stimulates autophagy 4 45 2.32630161961136 NA 4.70203685809961 4.62451455402945 0.077522304070162 1.26457442305802 0.944630711019738 0.0800671069596162 0.0613030776652085 0.0820662542153388 0.878693322430393 NA NA NA 0.91165266039922 99.727107917785 a10180 loss_cnaBRCA57 1066 AZD6482 PI3Kbeta 4 39 1.6094379124341 NA 1.86131281543102 1.97804659413836 -0.116733778707342 1.42622671543844 1.45214943355313 0.0804911572570206 0.081847982122153 0.0803868913282 0.878904303468888 NA NA NA 0.884506340770384 99.727107917785 a10181 PTEN_mut 203 BMS-345541 IKBKB 9 40 2.77258872223978 NA 3.57916975663995 3.52179368291684 0.0573760737231064 1.01078182147788 1.01638495361298 0.0565040238197661 0.0567640538283681 0.056451124664085 0.878931321858801 NA NA NA 0.880413453218394 99.727107917785 a10182 gain_cnaBRCA12_(TERT) 224 AS605240 PI3Kgamma 9 40 2.99573227355399 2.32630161961136 3.19693344430814 3.2867544929524 -0.089821048644255 1.02406346528833 1.68503105999953 0.0564193811535981 0.0877104317152505 0.0533052777343346 0.879111242038308 NA NA NA 0.837853069192178 99.727107917785 a10183 PIK3CA_mut 1033 Vismodegib SMO 16 29 2.30258509299405 NA 4.73557297948003 4.77312717117256 -0.0375541916925339 0.836547212590671 0.761550665719235 0.0476260066636367 0.0448918974653371 0.0493127947791451 0.879167707934548 NA NA NA 0.882791489643327 99.727107917785 a10184 TP53_mut 166 FTI-277 Farnesyl transferase (FNTA) 37 10 0.0237165266173161 NA 2.23486950752488 2.27960602796291 -0.0447365204380228 0.854318731515799 0.672355217014903 0.0544797863379376 0.0523651405356028 0.0665370317741302 0.879193854606424 NA NA NA 0.862627587268177 99.727107917785 a10185 PIK3CA_mut 157 JNK-9L JNK 16 31 1.63315443905142 NA 0.0888409879821504 0.038813748068009 0.0500272399141414 1.39996224392563 0.846830059398616 0.0470329817698563 0.0357347065116985 0.0590758905625867 0.879247077502954 NA NA NA 0.896958008451072 99.727107917785 a10186 BRCA2_mut 185 OSI-906 IGF1R 6 42 0.940007258491471 NA 2.95974802032931 2.88402446863487 0.0757235516944355 1.59731304569831 1.06638058479321 0.0666478970878134 0.0474068323040152 0.0710098746866438 0.879295243250485 NA NA NA 0.914243103851834 99.727107917785 a10187 ARID1A_mut 1230 IOX2 EGLN1 5 42 -2.30258509299405 NA 0.206942933536908 0.254524590734565 -0.0475816571976569 0.838166346233151 0.638515056077794 0.0722338604479173 0.0567687517060261 0.074519240767691 0.87932783831065 NA NA NA 0.907504350543382 99.727107917785 a10188 gain_cnaBRCA31 88 MS-275 HDAC 4 10 1.6094379124341 NA 1.25878314824922 1.09132801231743 0.167455135931787 2.03136866768417 1.75437819327875 0.0916274176102606 0.0824346356206685 0.0954498503078356 0.879491551586577 NA NA NA 0.890703913571937 99.727107917785 a10189 gain_cnaBRCA16 262 VX-11e ERK 16 33 1.63315443905142 NA 3.81871737355921 3.75649416086731 0.0622232126918982 1.24150740853987 1.38402759181884 0.046428647000212 0.0501190828696533 0.0449580724110614 0.879518320988145 NA NA NA 0.875137428080678 99.727107917785 a10190 loss_cnaBRCA20 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 3 42 2.30258509299405 NA 1.45971313349983 1.35858193546158 0.101131198038247 1.06143479009134 1.11329088494468 0.0910326995974034 0.0952778248671728 0.0908398689020725 0.879641664712818 NA NA NA 0.886497284204425 99.727107917785 a10191 loss_cnaBRCA57 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 41 1.38629436111989 NA 2.76263885969195 2.87031294936866 -0.107674089676709 0.747884655751307 1.54755070123216 0.0721355772618831 0.143971518667598 0.0695770998591385 0.879660964704692 NA NA NA 0.800001818593465 99.727107917785 a10192 gain_cnaBRCA31 263 FR-180204 ERK 16 33 2.99573227355399 NA 5.38093179409228 5.34671063253455 0.0342211615577304 0.702360415673593 0.754705413548069 0.0463448408181723 0.0487230783427776 0.0453437340496177 0.879734087731201 NA NA NA 0.876980809553783 99.727107917785 a10193 TP53_mut 1052 RO-3306 CDK1 34 9 1.6094379124341 NA 3.54013959443828 3.47102314412817 0.0691164503101103 1.28232137610466 0.856927960254686 0.0570687725328712 0.0538994760580745 0.08065608022589 0.87974539508654 NA NA NA 0.850021765943913 99.727107917785 a10194 gain_cnaBRCA58_(CCND1) 293 MP470 PDGFR 10 38 2.99573227355399 NA 3.60355126408418 3.51264673109961 0.0909045329845712 1.71403083054903 1.67394261642678 0.054049962994932 0.0530355296791558 0.0543056447052033 0.879790428973074 NA NA NA 0.88296423665288 99.727107917785 a10195 MLL3_mut 1036 PLX4720 BRAF 3 40 2.30258509299405 NA 4.49392561624155 4.60431743398189 -0.110391817740343 0.943689777908954 1.22436461423226 0.0910686922290613 0.116978927105633 0.0901625352914697 0.879827649852672 NA NA NA 0.862827227435876 99.727107917785 a10196 loss_cnaBRCA33 1502 Bicalutamide ANDR (androgen receptor) 5 40 2.30258509299405 NA 4.5206190840388 4.56301363906272 -0.0423945550239173 0.542892405374496 0.592519613943557 0.0720897966596197 0.0780901604152536 0.071549623044134 0.879914631025454 NA NA NA 0.876657772506686 99.727107917785 a10197 loss_cnaBRCA36_(FAT1,IRF2) 175 PAC-1 CASP3 agonist 9 39 0.940007258491471 NA 2.45754172055327 2.38842181900384 0.0691199015494322 0.856623100414232 1.2968167837847 0.0561213400414584 0.0806888134536744 0.0532996660852189 0.880038874236022 NA NA NA 0.847024462103785 99.727107917785 a10198 gain_cnaBRCA19 1375 Temozolomide DNA akylating agent 4 42 3.40119738166216 NA 5.84913234872966 5.90498246748196 -0.0558501187522964 0.38627202043943 0.721152676937952 0.0793999009026369 0.1445875336473 0.0774456235667579 0.880086834721541 NA NA NA 0.811613011443781 99.727107917785 a10199 loss_cnaBRCA22_(SYNCRIP,ZNF292) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 17 28 -0.669430653942629 NA -3.55729180784625 -3.44302344023938 -0.114268367606862 2.50126601347691 2.4192926665669 0.0466379649954094 0.0456842123113574 0.0472321390404636 0.880146424698937 NA NA NA 0.88134499677136 99.727107917785 a10200 gain_cnaBRCA48 1023 GW 441756 NTRK1 5 40 0.693147180559945 NA 2.2754267555392 2.36976929531415 -0.0943425397749547 0.848694990296636 1.35043919429757 0.0719136927492229 0.111161890730591 0.0698606350980705 0.880205685820921 NA NA NA 0.834790623757811 99.727107917785 a10201 loss_cnaBRCA29_(MAP2K4) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 7 36 1.6094379124341 NA 2.86636857766584 2.96137232348833 -0.0950037458224897 2.64882957459472 1.22295559469154 0.0625956734769223 0.0358663111940774 0.0776837247688064 0.880297595932523 NA NA NA 0.928712927531257 99.727107917785 a10202 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 134 Etoposide TOP2 6 41 2.77258872223978 NA 2.35152457184403 2.49547883717171 -0.143954265327683 2.3354802005643 2.15438886576205 0.0661781180644281 0.0616379729071995 0.0668190722740127 0.880334934452746 NA NA NA 0.891220124847571 99.727107917785 a10203 CDH1_mut 254 AC220 FLT3 4 44 0.0237165266173161 NA 2.28815654294233 2.21790783849778 0.0702487044445568 0.602446995077429 0.906390276800673 0.0789543280766759 0.116605618450347 0.0775038151253308 0.880490050698853 NA NA NA 0.841397838945328 99.727107917785 a10204 gain_cnaBRCA13_(FGFR1,WHSC1L1) 164 JQ12 HDAC 10 37 1.63315443905142 NA 1.50778356146946 1.59682901180438 -0.0890454503349198 1.48917104933136 1.69239180749624 0.0538446734316429 0.0597953138928545 0.0526151509009344 0.880591205347825 NA NA NA 0.87272882735612 99.727107917785 a10205 gain_cnaBRCA9_(KRAS) 151 QS11 ARFGAP 4 44 2.32630161961136 NA 3.65266768599138 3.7702482751887 -0.117580589197321 1.85435626502873 1.46300813163504 0.0788251272757166 0.0634077665736468 0.0803690606052299 0.880684103153734 NA NA NA 0.908851928752906 99.727107917785 a10206 loss_cnaBRCA36_(FAT1,IRF2) 268 YM155 BIRC5 (Survivin) 9 40 1.63315443905142 NA -3.52242701592375 -3.61203697383875 0.0896099579150018 1.66304737725497 1.59860270891251 0.0556668568848339 0.0538829856205975 0.056055177071457 0.880711122991127 NA NA NA 0.885599713528761 99.727107917785 a10207 loss_cnaBRCA17 202 GSK-1904529A IGF1R 11 37 0.0237165266173161 NA 2.15616927363024 2.19963541582147 -0.0434661421912375 0.613370075216937 0.891559025793418 0.0518091206380207 0.0708644649412744 0.0487529607504741 0.880743405671163 NA NA NA 0.855414049040583 99.727107917785 a10208 MLL3_mut 1114 Cetuximab EGFR 3 42 4.18661983833127 NA 6.20820663712368 6.28789779927661 -0.079691162152927 0.696382931296781 0.89278630245901 0.090085323242061 0.114435834899814 0.0892611837048047 0.880884506840959 NA NA NA 0.865440128947198 99.727107917785 a10209 gain_cnaBRCA48 1001 AICAR AAPK1 (AMPK) agonist 5 40 7.60090245954208 NA 7.82689527757306 7.72743179796556 0.0994634796075031 1.26097928377791 1.40430470319575 0.0714744463977623 0.0788779648381765 0.0708275628367233 0.880931720803714 NA NA NA 0.87569287478064 99.727107917785 a10210 ASH1L_mut 329 QL-XI-92 DDR1 3 45 2.32630161961136 NA 4.1730784840187 4.25868553913759 -0.0856070551188823 0.535215500241395 0.968339812455278 0.0897717664352347 0.15994875910782 0.0884060058439827 0.880987508876417 NA NA NA 0.818216814793594 99.727107917785 a10211 loss_cnaBRCA57 1059 AZD8055 MTORC1/2 5 38 0.693147180559945 NA 0.194750460563599 0.121967611686867 0.0727828488767322 0.51567426334226 1.05599225321696 0.0716361456748802 0.141141131234671 0.0689236579671939 0.881043401114733 NA NA NA 0.805493358655762 99.727107917785 a10212 loss_cnaBRCA34 177 GSK-650394 SGK3 5 42 2.77258872223978 NA 4.1231476459148 4.00149728329532 0.121650362619488 0.797350418966279 1.7726482025656 0.07119682472526 0.15256825572024 0.0686263424651434 0.881046863663518 NA NA NA 0.792267183115216 99.727107917785 a10213 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1018 ABT-888 PARP1, PARP2 5 40 1.6094379124341 NA 4.36061747409917 4.40838353176228 -0.0477660576631056 0.431297420267008 0.689393094238055 0.0713358374758353 0.110749694801176 0.0692871136400032 0.881160850506884 NA NA NA 0.835543481384942 99.727107917785 a10214 loss_cnaBRCA33 1042 BIRB 0796 p38, JNK2 5 38 2.30258509299405 NA 4.30769332694119 4.37434584772281 -0.0666525207816218 1.19404734868101 0.898444253388135 0.0715599109241737 0.0558206681294914 0.0741865959187424 0.881169018736793 NA NA NA 0.909219129612727 99.727107917785 a10215 loss_cnaBRCA23 303 PIK-93 PI4K, PI3K 3 46 2.99573227355399 NA 2.67111873483787 2.79937992563474 -0.128261190796879 1.12353354510399 1.44433084934337 0.0895588346320768 0.114158755077498 0.0888031927416009 0.881173568213251 NA NA NA 0.865411897132662 99.727107917785 a10216 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 34 Imatinib ABL, KIT, PDGFR 3 11 0.693147180559945 NA 2.73935414823143 2.78777764836246 -0.0484235001310274 0.893414177320896 0.35371610145223 0.0994060356417357 0.054200505611223 0.136899338006435 0.881235666671432 NA NA NA 0.934530229965387 99.727107917785 a10217 gain_cnaBRCA31 283 GSK2126458 PI3K, MTOR 16 32 -2.05572501506252 0.0237165266173161 -3.00509507718658 -3.08048931741733 0.0753942402307453 1.63048762915258 1.65352217801678 0.0458032309498581 0.0462403019089019 0.0455961469601651 0.881739910460697 NA NA NA 0.881510700384184 99.727107917785 a10218 gain_cnaBRCA62 1529 MLN4924 NEDD8-activating enzyme 6 31 0 NA 0.465054822179225 0.35066568206015 0.114389140119074 2.78803556939198 1.46250944012277 0.0666697937379077 0.0410285798986491 0.078214291806193 0.882032490392689 NA NA NA 0.925434947988159 99.727107917785 a10219 loss_cnaBRCA28_(GPS2) 1020 Lenalidomide TNFA 3 42 1.6094379124341 NA 4.19515574941691 4.25898163598895 -0.0638258865720376 0.266170956447467 0.730765077353476 0.0891580595328078 0.239792828728985 0.0873411833022839 0.882101257828112 NA NA NA 0.75225135941646 99.727107917785 a10220 loss_cnaBRCA34 1261 rTRAIL TR10A (DR4), TR10B (DR5) 5 42 -2.30258509299405 NA -0.0747303638870512 -0.148448130456277 0.0737177665692257 0.426402030331822 1.08661125151411 0.0705463074973171 0.172883244744072 0.0678418951271726 0.882125479231376 NA NA NA 0.77657807355657 99.727107917785 a10221 loss_cnaBRCA22_(SYNCRIP,ZNF292) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 19 30 3.68887945411394 NA 3.49164553124911 3.4390735710504 0.0525719601987058 1.37886531385138 1.08095424517404 0.0436720150882899 0.0381269727148799 0.0486347691712348 0.882229798715546 NA NA NA 0.888759805709666 99.727107917785 a10222 loss_cnaBRCA20 222 BX-912 PDPK1 (PDK1) 3 46 2.32630161961136 NA 4.01058140775314 3.87551117370351 0.135070234049638 1.40999252902316 1.52743132662769 0.0887091790886987 0.0957949998098317 0.0884296607611488 0.882292371098682 NA NA NA 0.885825204532093 99.727107917785 a10223 gain_cnaBRCA10_(MDM2,NUP107) 295 NVP-BHG712 EPHB4 5 44 2.32630161961136 NA 3.96479795288911 3.87783442269603 0.0869635301930809 1.08172865551423 1.2513319133235 0.0702563771210868 0.0803931094454926 0.0694967732119198 0.882295333259476 NA NA NA 0.873198798465848 99.727107917785 a10224 PTEN_mut 1091 BMS-536924 IGF1R 8 39 1.38629436111989 NA 2.97043771358665 3.0341462203448 -0.0637085067581533 1.19417552881035 1.08499451074165 0.0577756170789413 0.0533493655004139 0.0587178148160447 0.882330572595443 NA NA NA 0.891929296986588 99.727107917785 a10225 loss_cnaBRCA22_(SYNCRIP,ZNF292) 89 Parthenolide NFKB1 4 10 1.6094379124341 NA 3.34232558073533 3.21288166333641 0.12944391739892 1.37741147523232 1.469835894367 0.0894392433565424 0.0939762153332484 0.0880669181471217 0.882345504018281 NA NA NA 0.881353001363995 99.727107917785 a10226 gain_cnaBRCA63 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 38 1.6094379124341 NA 2.66845774709916 2.55403661486634 0.114421132232815 3.34318533964218 1.29907749858749 0.0707790017274116 0.0342251836522655 0.0880787577009279 0.882455958379464 NA NA NA 0.943098611901968 99.727107917785 a10227 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1042 BIRB 0796 p38, JNK2 15 28 2.30258509299405 NA 4.33774649574161 4.38205040757317 -0.0443039118315625 0.942795795752647 0.925479582474703 0.0475655464375457 0.0469920549403745 0.0478713011832149 0.882553720948071 NA NA NA 0.883545461212929 99.727107917785 a10228 loss_cnaBRCA29_(MAP2K4) 165 DMOG Prolyl-4-Hydroxylase 7 39 8.29404964010203 NA 7.48999574181703 7.58433683050748 -0.0943410886904461 1.62417611984565 1.53429525515434 0.0609887977806858 0.0580855041135635 0.0614882229307006 0.882566041050781 NA NA NA 0.890054222258758 99.727107917785 a10229 loss_cnaBRCA29_(MAP2K4) 1218 JQ1 BRD2, BRD3, BRD4 7 39 0 NA 2.4214351188657 2.46454154564812 -0.043106426782419 0.994408338183021 0.650680149928611 0.0609316439811873 0.0433488187168492 0.0662482585140309 0.882675266416863 NA NA NA 0.915118682710463 99.727107917785 a10230 CDH1_mut 229 LY317615 PRKCB (PKCbeta) 4 45 2.99573227355399 2.32630161961136 3.47414520991426 3.34831088196932 0.125834327944935 1.83779929431414 1.60999403194038 0.0774132165141779 0.0684701144103424 0.078158257390109 0.882683582873961 NA NA NA 0.902007809919481 99.727107917785 a10231 loss_cnaBRCA7_(FAS,PTEN) 1001 AICAR AAPK1 (AMPK) agonist 4 41 7.60090245954208 NA 7.83679626925679 7.7288917860844 0.10790448317239 1.94182345872038 1.34127338221581 0.0775394359566849 0.0555686371424807 0.0804492839439855 0.88301413548824 NA NA NA 0.919790778188626 99.727107917785 a10232 gain_cnaBRCA19 1129 PF-4708671 RPS6KB1 (p70S6KA) 3 40 2.30258509299405 NA 3.90414136991705 3.80182883985367 0.102312530063375 1.8624032028191 1.1058830755245 0.0886323771115108 0.054935757148885 0.0925165890750707 0.883018243882405 NA NA NA 0.9333479922442 99.727107917785 a10233 gain_cnaBRCA12_(TERT) 1036 PLX4720 BRAF 9 34 2.30258509299405 NA 4.64975247033987 4.58255005808651 0.0672024122533577 0.874462268686096 1.28073341319319 0.0554383552667053 0.0768499850248899 0.0524718193193735 0.88315504052592 NA NA NA 0.855945040950904 99.727107917785 a10234 loss_cnaBRCA18 1061 SB590885 BRAF 12 30 1.6094379124341 NA 4.05150162012032 3.9960757269326 0.0554258931877216 0.77384168213476 1.19709373526285 0.0505203798681004 0.0716243315232398 0.0463003786211876 0.883158045513858 NA NA NA 0.860377262355753 99.727107917785 a10235 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1036 PLX4720 BRAF 5 38 2.30258509299405 NA 4.52126361653417 4.60653042435077 -0.0852668078165983 0.577773845449851 1.26182378991684 0.0703404968716372 0.147578171784862 0.0675742591778351 0.883178756426622 NA NA NA 0.801057636474795 99.727107917785 a10236 loss_cnaBRCA36_(FAT1,IRF2) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 8 37 2.30258509299405 NA 1.3126922543158 1.37670385555026 -0.0640116012344585 1.17007814828896 1.09908386846938 0.0576187812329381 0.0547071162110537 0.0582408704838906 0.883210388499132 NA NA NA 0.890095132681078 99.727107917785 a10237 PIK3CA_mut 225 Genentech Cpd 10 AURKA, AURKB 17 32 2.32630161961136 NA 2.97118532436983 3.0429674494751 -0.0717821251052637 1.80749838168779 1.52284201357427 0.0441640240592079 0.0397135210921935 0.0471369481964735 0.883640442614497 NA NA NA 0.89001746993028 99.727107917785 a10238 loss_cnaBRCA57 136 Mitomycin C DNA crosslinker 5 43 2.77258872223978 NA -0.0415614125347746 -0.14508945701709 0.103528044482315 0.802063150854768 1.53901234105661 0.0695063815363233 0.129077173501842 0.0672691451007068 0.883693106188166 NA NA NA 0.815214705179835 99.727107917785 a10239 gain_cnaBRCA61_(NOTCH2) 341 EX-527 SIRT1 3 46 2.99573227355399 NA 5.69598557398498 5.63821634736657 0.0577692266184018 0.205785140509305 0.672359856591251 0.0876264602809613 0.280725938109169 0.0859201007497411 0.883718416272387 NA NA NA 0.722539975085203 99.727107917785 a10240 TP53_mut 1046 681640 WEE1, CHEK1 27 9 0.693147180559945 NA 2.64905421219407 2.58801689782158 0.0610373143724878 1.05763108195376 1.13773268765077 0.05667268894384 0.0577113470036582 0.0536482031631874 0.883812282932551 NA NA NA 0.889412945280761 99.727107917785 a10241 gain_cnaBRCA10_(MDM2,NUP107) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 3 43 2.30258509299405 NA 1.33092182476533 1.41891350299594 -0.0879916782306094 1.25016483881863 0.989480171480935 0.0877459282832438 0.0703840609641196 0.0889271768820936 0.883849839530041 NA NA NA 0.915120605017825 99.727107917785 a10242 loss_cnaBRCA38 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 3 40 1.6094379124341 NA 3.06993697272462 2.93660431927667 0.133332653447944 0.515668784747898 1.55180586780215 0.0878481381202616 0.25856258395227 0.0859209622894295 0.884045703386861 NA NA NA 0.74245272564586 99.727107917785 a10243 gain_cnaBRCA31 293 MP470 PDGFR 16 32 2.99573227355399 NA 3.58181412932038 3.5064706985469 0.0753434307734779 1.95688878989538 1.53120111525547 0.0447968138697454 0.0385016415662057 0.0492054440287601 0.884319299267061 NA NA NA 0.893907077896274 99.727107917785 a10244 loss_cnaBRCA23 286 KIN001-236 TIE2 3 46 2.32630161961136 NA 4.60330494635412 4.53598218951043 0.0673227568436863 0.688223659966028 0.776082281663559 0.0871438765436721 0.0978210438842069 0.086746931909562 0.884354151249987 NA NA NA 0.883641655489259 99.727107917785 a10245 ARID1A_mut 271 VNLG/124 HDAC, RAR 5 44 1.63315443905142 NA 4.10078947893665 4.1571958586641 -0.0564063797274441 0.816033382076945 0.819331020823517 0.0688679794880815 0.0691226375860754 0.0688444331947172 0.884604419949914 NA NA NA 0.889363031907172 99.727107917785 a10246 loss_cnaBRCA7_(FAS,PTEN) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 4 43 2.32630161961136 NA 1.30925408782146 1.42695322382228 -0.117699136000821 1.50269104436916 1.54713763443973 0.0762194300247593 0.0783255722737283 0.0760754139649919 0.884724248698516 NA NA NA 0.889148257724923 99.727107917785 a10247 ARID1A_mut 272 AR-42 HDAC 5 44 1.63315443905142 NA 0.0467787758919742 0.152785648082994 -0.10600687219102 1.52904079634352 1.54217069377223 0.0687883901564477 0.0693290018451568 0.0687387411906537 0.884736818271734 NA NA NA 0.889076596597781 99.727107917785 a10248 loss_cnaBRCA34 153 Midostaurin KIT 5 42 -0.669430653942629 NA 0.702508401197721 0.601431167330032 0.101077233867689 1.02062797218926 1.50292460625735 0.0689245547690089 0.0990343559278286 0.0672536955259495 0.884815469447747 NA NA NA 0.849719177252764 99.727107917785 a10249 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1129 PF-4708671 RPS6KB1 (p70S6KA) 5 38 2.30258509299405 NA 3.73840113913268 3.81825189495354 -0.0798507558208628 1.2577780615239 1.14261702249258 0.0691732968001235 0.0634855689278897 0.0698840943631935 0.885103170139445 NA NA NA 0.898101701553372 99.727107917785 a10250 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1527 GDC0941 (rescreen) PI3K 8 37 1.38629436111989 NA 1.03493696716752 0.968919381730338 0.0660175854371799 0.984974010334993 1.1971168569083 0.0566569049430369 0.067024697854441 0.055147152139916 0.885145934979857 NA NA NA 0.871670306337038 99.727107917785 a10251 MACF1_mut 1218 JQ1 BRD2, BRD3, BRD4 3 43 0 NA 2.51535676960455 2.45397897217495 0.0613777974295928 0.358158165137944 0.719881161922914 0.0867576148720588 0.171370649628924 0.085261013450669 0.885148642136416 NA NA NA 0.808835239736838 99.727107917785 a10252 PTEN_mut 306 TG101348 JAK2 9 39 2.32630161961136 NA 3.28126550804874 3.21187895248983 0.0693865555589088 1.30169706666004 1.29065613297321 0.0536805387390863 0.0533046876543592 0.0537606832573343 0.885217989531359 NA NA NA 0.887619321440157 99.727107917785 a10253 gain_cnaBRCA12_(TERT) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 9 39 0.246860077931526 2.32630161961136 -0.192388687241172 -0.281697221545424 0.0893085343042517 1.58266785704803 1.68246320228671 0.0536214627599766 0.0564291072864957 0.0530820134329647 0.885343406095092 NA NA NA 0.882559031762517 99.727107917785 a10254 loss_cnaBRCA34 1007 Docetaxel Microtubules 5 40 -4.38202663467388 NA -4.49218616838312 -4.59916634142016 0.106980173037036 1.74323467993943 1.53500974767849 0.0687729591358503 0.0613687728153466 0.0696934812295691 0.885399292747549 NA NA NA 0.901062203354932 99.727107917785 a10255 loss_cnaBRCA60 300 CX-5461 RNA Pol I 3 46 2.32630161961136 NA 3.77302208221457 3.92145289394171 -0.148430811727143 1.36351298742252 1.73445470807467 0.0862819287582994 0.108859111058212 0.085577796316116 0.885489835029352 NA NA NA 0.871487023707397 99.727107917785 a10256 loss_cnaBRCA33 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 6 40 1.63315443905142 NA 1.84818707692529 1.94985615835714 -0.101669081431852 0.943825053678901 1.67032514635488 0.0633680401268817 0.107720261329745 0.0608678386083826 0.885574927746842 NA NA NA 0.831877181384397 99.727107917785 a10257 gain_cnaBRCA15 1059 AZD8055 MTORC1/2 20 23 0.693147180559945 NA 0.154479877115802 0.109518434982735 0.0449614421330675 0.856873358436855 1.13567121736433 0.0442521376216022 0.052471513661118 0.0395901925184069 0.885627850509572 NA NA NA 0.883392904615501 99.727107917785 a10258 gain_cnaBRCA63 329 QL-XI-92 DDR1 7 41 2.32630161961136 NA 4.20522709492646 4.26154865972591 -0.0563215647994459 1.40427519888516 0.866034509909545 0.0590604003707479 0.0401072132044767 0.0650338573751854 0.885802490530691 NA NA NA 0.921066172602675 99.727107917785 a10259 gain_cnaBRCA62 1061 SB590885 BRAF 7 35 1.6094379124341 NA 3.95726999493476 4.02284003671081 -0.0655700417760521 2.19168017825371 0.753922858587212 0.0597659355254178 0.0299177053416147 0.0869718181763647 0.885950164441798 NA NA NA 0.940072583076159 99.727107917785 a10260 loss_cnaBRCA22_(SYNCRIP,ZNF292) 184 BMS-754807 IGF1R 18 30 0.940007258491471 NA 1.58142571598736 1.65413489789539 -0.0727091819080314 1.68119805797707 1.69663943298949 0.0429990322242751 0.0432484332009758 0.0428548225947557 0.885954284960809 NA NA NA 0.885859861318024 99.727107917785 a10261 gain_cnaBRCA19 261 TL-1-85 MAP3K7 (TAK1) 4 45 2.32630161961136 NA 3.94048538397429 4.03230167322879 -0.0918162892544956 1.23931503898589 1.21938547234003 0.0752181120052623 0.0740863189473013 0.0752971815207031 0.8859863633782 NA NA NA 0.894660814425099 99.727107917785 a10262 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 135 Gemcitabine DNA replication 15 32 0.0237165266173161 NA -0.360727791036608 -0.235143700999426 -0.125584090037183 2.82633312268495 2.76491488912911 0.0451065061737151 0.0444335768594328 0.0454205988513227 0.886026645059742 NA NA NA 0.887368464750638 99.727107917785 a10263 loss_cnaBRCA22_(SYNCRIP,ZNF292) 261 TL-1-85 MAP3K7 (TAK1) 19 30 2.32630161961136 NA 3.99323553166458 4.04480139098552 -0.0515658593209425 1.27171471971492 1.18788036151449 0.0422439809092538 0.0405482916266802 0.0434099771253047 0.886053184983836 NA NA NA 0.887981008340431 99.727107917785 a10264 loss_cnaBRCA23 1268 XAV 939 TNKS1 (tankyrase-1) 3 44 1.6094379124341 NA 3.7375062209964 3.6562565356384 0.0812496853580003 0.384239810349928 0.964535018944918 0.0858576078454319 0.211455666928437 0.0842371544445088 0.886233376520539 NA NA NA 0.774457391105129 99.727107917785 a10265 loss_cnaBRCA22_(SYNCRIP,ZNF292) 175 PAC-1 CASP3 agonist 18 30 0.940007258491471 NA 2.36839217630824 2.42117557508603 -0.0527833987777973 1.41647490403697 1.10907045879408 0.0428559467178888 0.0372639138380525 0.0475924666095515 0.886331121765606 NA NA NA 0.893389760595437 99.727107917785 a10266 CDH1_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 4 39 2.30258509299405 NA 3.88800249469117 3.80086071090085 0.0871417837903117 0.727082483177038 1.18153474761075 0.0754889539075453 0.119851304090754 0.0737530436295047 0.886375199910658 NA NA NA 0.840318057676026 99.727107917785 a10267 gain_cnaBRCA31 290 KIN001-260 IKK 16 33 2.99573227355399 NA 5.07499344248563 5.02908221320598 0.0459112292796453 1.53593598693612 0.71533066303489 0.0437489118420901 0.0298913689568722 0.0641818275828699 0.886422030707865 NA NA NA 0.910691736089165 99.727107917785 a10268 gain_cnaBRCA30_(CRNKL1,FOXA2) 1527 GDC0941 (rescreen) PI3K 4 41 1.38629436111989 NA 1.06052019482499 0.972864197123481 0.0876559977015042 1.08629444724974 1.17092881005641 0.0752267624193794 0.080692668478082 0.0748602280076119 0.886478483727213 NA NA NA 0.886381590674543 99.727107917785 a10269 gain_cnaBRCA12_(TERT) 1008 Methotrexate Dihydrofolate reductase (DHFR) 10 35 -1.6094379124341 NA 0.726617099018206 0.670088067428621 0.0565290315895853 0.950073344584065 1.13414957891911 0.0514752846682946 0.0594996501184162 0.0498426597693223 0.886520399176625 NA NA NA 0.87583362876871 99.727107917785 a10270 gain_cnaBRCA10_(MDM2,NUP107) 1030 KU-55933 ATM 3 39 2.30258509299405 NA 4.29660277939817 4.21658370702094 0.0800190723772296 0.242495997710344 0.95263551475115 0.0860331151153217 0.329981002296007 0.0839975742434213 0.886542669316627 NA NA NA 0.708222023047618 99.727107917785 a10271 loss_cnaBRCA22_(SYNCRIP,ZNF292) 71 Pyrimethamine Dihydrofolate reductase (DHFR) 4 10 2.99573227355399 NA 4.50594650954333 4.59500037579454 -0.0890538662512155 0.911318819090642 1.07043970563115 0.0862123082196318 0.0977197709360131 0.0831937247681859 0.886557410519432 NA NA NA 0.880053971609288 99.727107917785 a10272 gain_cnaBRCA15 1066 AZD6482 PI3Kbeta 20 23 1.6094379124341 NA 2.00121805340243 1.93759597239441 0.0636220810080259 1.51180854886314 1.39503680868824 0.0438676176874329 0.0420834245552249 0.0456060231613889 0.88661466920176 NA NA NA 0.887293014954242 99.727107917785 a10273 gain_cnaBRCA8_(CHD4,WNK1) 1054 PD-0332991 CDK4, CDK6 3 39 1.38629436111989 0.693147180559945 2.76497794076151 2.89197603043528 -0.126998089673764 0.757088117242849 1.50636314465011 0.085928614569996 0.167745453641861 0.0843077515038797 0.886679514747674 NA NA NA 0.813878443382367 99.727107917785 a10274 loss_cnaBRCA36_(FAT1,IRF2) 150 Bicalutamide ANDR (androgen receptor) 9 39 0.0237165266173161 NA 2.73556675248717 2.76882335675244 -0.0332566042652678 0.34768692037987 0.672331116681973 0.0529526803410023 0.0956510076045796 0.0494646215831758 0.88676341762398 NA NA NA 0.835255303424155 99.727107917785 a10275 ARID1A_mut 203 BMS-345541 IKBKB 5 44 2.77258872223978 NA 3.59393638641689 3.52533166350792 0.068604722908967 0.47204993514729 1.0518385416149 0.0675598814485793 0.145333613672801 0.0652236252948453 0.886780884298279 NA NA NA 0.800529141949203 99.727107917785 a10276 gain_cnaBRCA47_(EGFR) 304 SB52334 ALK5 7 42 2.99573227355399 NA 4.23769185846945 4.31259172937925 -0.0748998709098023 1.59520178905091 1.23014966947728 0.0583991489988288 0.0469532264970471 0.0608867951341473 0.886863706314577 NA NA NA 0.908898736557345 99.727107917785 a10277 loss_cnaBRCA34 1219 PFI-1 BRD2, BRD3, BRD4 5 42 2.30258509299405 NA 3.11173317526225 3.1797129537673 -0.0679797785050531 0.713108407686479 1.02951884096791 0.0676123903879255 0.0953288136450366 0.0660306308150141 0.886992953939638 NA NA NA 0.854782720234741 99.727107917785 a10278 loss_cnaBRCA36_(FAT1,IRF2) 1067 CCT007093 PPM1D 9 37 1.88706964903238 NA 4.12807573754732 4.07531309896654 0.0527626385807789 1.1705847991955 0.949334551713226 0.0531220360266687 0.0450737431555926 0.055578550770706 0.886999425543006 NA NA NA 0.90241467233551 99.727107917785 a10279 loss_cnaBRCA38 222 BX-912 PDPK1 (PDK1) 4 45 2.32630161961136 NA 3.77959621761159 3.89304162984832 -0.113445412236729 1.60668730157323 1.51674756789934 0.0745053856707492 0.0706082708972966 0.0747951832181597 0.887059182690648 NA NA NA 0.899339209925373 99.727107917785 a10280 BRCA2_mut 266 Zibotentan, ZD4054 Endothelin A Receptor 6 43 2.99573227355399 NA 5.71496817307671 5.74581676284154 -0.0308485897648332 0.331803297349437 0.512056253422361 0.0621942462867051 0.0929725232125863 0.0602445328196944 0.88712730525065 NA NA NA 0.848094852373151 99.727107917785 a10281 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 190 Bleomycin DNA damage 6 42 4.15888308335967 NA 2.22900594499577 2.05688390080565 0.172122044190119 2.50533659962722 2.79361436747051 0.0622787397217127 0.0687021633004246 0.0616126714532786 0.887151510598207 NA NA NA 0.881196034600993 99.727107917785 a10282 loss_cnaBRCA60 166 FTI-277 Farnesyl transferase (FNTA) 3 44 0.0237165266173161 NA 2.17893152426917 2.24885085193733 -0.0699193276681571 0.596413024031831 0.830160253903072 0.0851443714045891 0.117233066433548 0.0842238921213407 0.887171894675783 NA NA NA 0.862749655592882 99.727107917785 a10283 gain_cnaBRCA30_(CRNKL1,FOXA2) 268 YM155 BIRC5 (Survivin) 5 44 1.63315443905142 NA -3.69273407240393 -3.58453753942827 -0.108196532975657 1.65740089718081 1.6052966955643 0.0672113002733065 0.0652808461487476 0.0673997107666278 0.887361016684442 NA NA NA 0.895166712348148 99.727107917785 a10284 TP53_mut 302 PI-103 PI3Ka, PRKDC (DNAPK) 37 11 2.32630161961136 NA 1.10750928248646 1.1988134726753 -0.0913041901888401 1.84758566191603 1.93809769044887 0.0488875888529851 0.0494181093038758 0.0471102105114699 0.887420662196467 NA NA NA 0.891487180678416 99.727107917785 a10285 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1042 BIRB 0796 p38, JNK2 8 35 2.30258509299405 NA 4.32427736838241 4.37626828288896 -0.0519909145065487 0.796438510656091 0.956883753826099 0.0558172305852866 0.0652792573575072 0.0543335742702946 0.887435019979847 NA NA NA 0.875438218126881 99.727107917785 a10286 NF1_mut 1023 GW 441756 NTRK1 4 41 0.693147180559945 NA 2.44843882265293 2.35058903169879 0.0978497909541352 1.25505627154092 1.31609320060593 0.0745847854070928 0.0779644651582023 0.0743486790366255 0.887440556478549 NA NA NA 0.889968423019408 99.727107917785 a10287 gain_cnaBRCA64_(SDHC) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 7 36 1.6094379124341 NA 2.48773221852802 2.5828209602978 -0.0950887417697777 2.76286932550121 1.32398767724786 0.0588189739740118 0.0344166627397507 0.0718199598106807 0.887468370501366 NA NA NA 0.931674033188477 99.727107917785 a10288 gain_cnaBRCA12_(TERT) 1004 Vinblastine Microtubules 10 35 -2.30258509299405 NA -3.50675480019605 -3.44093337149435 -0.0658214287017027 0.80534685917753 1.39429999960315 0.0508896243546488 0.0817305338086543 0.0472075082266634 0.887802619443675 NA NA NA 0.851025441544443 99.727107917785 a10289 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 197 Bryostatin 1 PRKC 6 42 -4.8283137373023 NA -2.75408516296481 -2.8143351745371 0.060250011572291 0.66256730773586 1.00489984817743 0.0618876535258949 0.0909341750926087 0.0599562351228988 0.887855301297194 NA NA NA 0.851199054259533 99.727107917785 a10290 gain_cnaBRCA63 286 KIN001-236 TIE2 7 42 2.32630161961136 NA 4.57843313774191 4.53371579981783 0.0447173379240828 1.26368415905589 0.671190265835025 0.0578821946845728 0.0353864829305857 0.0666239369077414 0.887858335038359 NA NA NA 0.929821868542419 99.727107917785 a10291 loss_cnaBRCA28_(GPS2) 276 CAY10603 HDAC6 4 45 2.99573227355399 NA 1.10773109695427 1.18156718080966 -0.073836083855392 0.656767832058882 1.01809187322981 0.0739143497146121 0.112423416999468 0.0725239890395678 0.887948991746426 NA NA NA 0.847361687747311 99.727107917785 a10292 ARID1A_mut 293 MP470 PDGFR 5 43 2.99573227355399 NA 3.63244739955549 3.51985700988022 0.112590389675272 0.753338634971756 1.74476620293792 0.0669417043018161 0.149455217678425 0.0645303591310324 0.887954838937184 NA NA NA 0.798353873108292 99.727107917785 a10293 BRCA2_mut 158 PF-562271 FAK 6 39 0.940007258491471 NA 2.26329820658221 2.34401205154935 -0.080713844967133 1.46543898457439 1.27553863903094 0.0621331134537438 0.055078270618394 0.0632782437923271 0.887990333937787 NA NA NA 0.90243079030706 99.727107917785 a10294 loss_cnaBRCA18 1024 CEP-701 FLT3, JAK2, NTRK1, RET 14 31 0.693147180559945 NA 0.671022321592611 0.605041580764845 0.0659807408277656 1.59085640394655 1.38006315775734 0.0455972481569197 0.0414749820688295 0.0478099429412979 0.888053725694866 NA NA NA 0.894556611139004 99.727107917785 a10295 ASH1L_mut 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 42 2.30258509299405 NA 3.07323011311601 3.18426961144018 -0.111039498324165 0.60190277366025 1.33760154289658 0.0845977260798292 0.18448078856477 0.0830138832553295 0.888089442381762 NA NA NA 0.798411479767234 99.727107917785 a10296 loss_cnaBRCA33 154 CHIR-99021 GSK3B 6 41 0.940007258491471 NA 3.22620668880564 3.28264127444415 -0.0564345856385113 0.450697465567743 0.954979324959937 0.0618250622872376 0.125216114910743 0.0590950863160088 0.888150864813721 NA NA NA 0.815378404640807 99.727107917785 a10297 loss_cnaBRCA34 1161 ZG-10 IRAK1 3 23 2.30258509299405 NA 2.08504219665561 1.96111082295123 0.123931373704389 0.796855232691094 1.4653950290546 0.0871687107496058 0.155525581837311 0.0845719899734767 0.888262727290132 NA NA NA 0.8332370187018 99.727107917785 a10298 PIK3CA_mut 330 XMD13-2 RIPK 16 32 2.32630161961136 NA 3.68568494223794 3.73868939536996 -0.053004453132028 1.38461079881581 1.14060408295685 0.0432505357570692 0.0382811207144707 0.0464705097272856 0.888284779966327 NA NA NA 0.895775065704122 99.727107917785 a10299 gain_cnaBRCA47_(EGFR) 1042 BIRB 0796 p38, JNK2 6 37 2.30258509299405 NA 4.31675626036683 4.37467760232357 -0.0579213419567406 1.65098052160402 0.780724361934294 0.0621838675626396 0.0350829953465875 0.0741892334616494 0.888330609295082 NA NA NA 0.935782505293128 99.727107917785 a10300 PIK3CA_mut 205 BMS-708163 g-secretase 16 32 2.32630161961136 0.940007258491471 4.87682417158372 4.90638219063758 -0.0295580190538596 0.689345385685341 0.681432757600844 0.0432120238679644 0.0428783882037206 0.0433762814073189 0.888383582269767 NA NA NA 0.889150918330256 99.727107917785 a10301 PTEN_mut 1039 SL 0101-1 RSK, AURKB, PIM3 6 37 2.30258509299405 NA 4.59688353126383 4.65725184475993 -0.0603683134960997 1.12789820719191 0.948617789101283 0.0620911683232492 0.0535228384185455 0.0636381840923439 0.888495949140188 NA NA NA 0.905104219644772 99.727107917785 a10302 gain_cnaBRCA19 298 OSI-930 KIT, VEGFR, PDGFR 4 44 2.32630161961136 NA 3.8539539564691 3.91876850916706 -0.0648145526979613 1.67436219427789 0.795876735414419 0.0736269488355811 0.0387099953161054 0.081437928530744 0.888497489474214 NA NA NA 0.943557904727099 99.727107917785 a10303 gain_cnaBRCA9_(KRAS) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 4 39 0.693147180559945 NA 1.56885405534905 1.69354630024387 -0.124692244894825 1.20811338457937 1.71696640154099 0.0740034344701039 0.103212369373955 0.0726235788789539 0.888595904743217 NA NA NA 0.859401150502336 99.727107917785 a10304 gain_cnaBRCA16 89 Parthenolide NFKB1 3 11 1.6094379124341 NA 3.35582733812968 3.22096699471968 0.134860343410004 1.60403423085207 1.41402605742971 0.0931724487277668 0.0840757265749656 0.0953733085054608 0.888626534375835 NA NA NA 0.903373537146078 99.727107917785 a10305 gain_cnaBRCA14_(RAD21) 207 AS601245 JNK 21 27 2.07944154167984 NA 2.23640342856273 2.28937637894098 -0.0529729503782521 1.37576239147327 1.22538069670273 0.0409717181103658 0.0385044326742532 0.0432297901548411 0.888629363327758 NA NA NA 0.890329297385834 99.727107917785 a10306 loss_cnaBRCA57 344 THZ-2-49 CDK9 5 44 2.99573227355399 NA 1.87377739314676 1.77521790471941 0.0985594884273542 0.929104448986437 1.52588551395203 0.0663939211001557 0.106080095230276 0.064591666626473 0.888721598188342 NA NA NA 0.841707229379735 99.727107917785 a10307 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 5 21 2.30258509299405 NA 4.74297534391328 4.67217663459665 0.070798709316624 0.562453939453684 1.07401623078961 0.0703087893180695 0.12587467941889 0.0659195897482604 0.888818555618721 NA NA NA 0.840262078264203 99.727107917785 a10308 gain_cnaBRCA12_(TERT) 1259 BMN-673 PARP1 10 36 2.30258509299405 NA 3.36718517032035 3.28841383776778 0.0787713325525754 1.21342957286963 1.64803297240048 0.0502060380526685 0.0649162788791194 0.0477971823815147 0.888943799625688 NA NA NA 0.869166866196845 99.727107917785 a10309 gain_cnaBRCA61_(NOTCH2) 330 XMD13-2 RIPK 3 45 2.32630161961136 NA 3.81718969930929 3.71461001399373 0.102579685315557 1.02833890608525 1.233739004368 0.0837026723573705 0.0997528000822846 0.0831453694439241 0.888977654641835 NA NA NA 0.881790421307725 99.727107917785 a10310 gain_cnaBRCA13_(FGFR1,WHSC1L1) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 11 38 1.63315443905142 NA 3.61415116952841 3.56580329333347 0.0483478761949421 1.35389903899773 0.890599278752629 0.0480030797690559 0.0357101045220721 0.0542869024806061 0.889098252758639 NA NA NA 0.91285813428086 99.727107917785 a10311 BRCA2_mut 1026 17-AAG HSP90 5 38 0 NA -0.790028048306869 -0.910177518899401 0.120149470592531 2.6681995929702 1.68087830150145 0.0667057381602463 0.0450301659999815 0.0714801722915973 0.889173841861471 NA NA NA 0.926091245356167 99.727107917785 a10312 ARID1A_mut 165 DMOG Prolyl-4-Hydroxylase 5 41 8.29404964010203 NA 7.66140303447776 7.55883149780786 0.102571536669898 1.70611158132947 1.53007115131745 0.0663076767368211 0.0601200635365069 0.0670371025436172 0.88931566726789 NA NA NA 0.903102307778745 99.727107917785 a10313 gain_cnaBRCA9_(KRAS) 200 LAQ824 HDAC 4 44 0.0237165266173161 NA -2.58928957371046 -2.69311994044631 0.10383036673585 0.975959702550788 1.44712676100607 0.0730598807418658 0.106387965060931 0.0717493239249238 0.889350541831295 NA NA NA 0.854804147019486 99.727107917785 a10314 loss_cnaBRCA57 1031 Elesclomol HSP70 4 40 -1.6094379124341 NA -2.85748882541404 -2.98958809508641 0.132099269672371 0.888084246288283 1.85130261350614 0.0734015339613591 0.148746326966698 0.0713547686416276 0.889351820176771 NA NA NA 0.812009918195585 99.727107917785 a10315 gain_cnaBRCA58_(CCND1) 271 VNLG/124 HDAC, RAR 10 39 1.63315443905142 NA 4.18372816094582 4.14316111708834 0.0405670438574859 0.621620837833422 0.859209541008017 0.0495284005151646 0.0652601093600353 0.0472143777755226 0.889470671450799 NA NA NA 0.867535599344055 99.727107917785 a10316 CDH1_mut 222 BX-912 PDPK1 (PDK1) 4 45 2.32630161961136 NA 3.78185180751515 3.892841132968 -0.11098932545285 1.08020541216295 1.54823100018201 0.072891671001631 0.102748351566403 0.0716878330428742 0.889488985911094 NA NA NA 0.858929398855547 99.727107917785 a10317 NF1_mut 256 JW-7-24-1 LCK 4 44 2.32630161961136 NA 1.91586151171718 1.83045163926899 0.0854098724481833 0.669130162439996 1.19965841103677 0.0728504785791369 0.127643136182555 0.0711951599408788 0.889665583386616 NA NA NA 0.831234077980866 99.727107917785 a10318 gain_cnaBRCA9_(KRAS) 281 CH5424802 ALK 4 44 1.63315443905142 NA 3.50363702452672 3.58174895345828 -0.0781119289315595 0.723958161258152 1.09302306305903 0.0728091860773846 0.107895639709083 0.071464117795418 0.889727709293073 NA NA NA 0.85311868460048 99.727107917785 a10319 TP53_mut 86 A-443654 AKT1, AKT2, AKT3 9 3 0.0237165266173161 NA -1.30581630884765 -1.18306948815883 -0.122746820688828 1.34499627492181 1.07028239318463 0.0948053210437829 0.0912618294767869 0.114686386948396 0.889740063701518 NA NA NA 0.879446999320922 99.727107917785 a10320 gain_cnaBRCA62 1248 FK866 NAMPT 8 36 0 NA -0.528731421864148 -0.677811303366545 0.149079881502398 3.44553727494816 2.57047172707019 0.054491794095938 0.0432675282854517 0.0579970905466126 0.889790752710681 NA NA NA 0.910678171474589 99.727107917785 a10321 gain_cnaBRCA30_(CRNKL1,FOXA2) 256 JW-7-24-1 LCK 5 43 2.32630161961136 NA 1.76843676335089 1.84560777576628 -0.0771710124153901 0.493512995750997 1.21747016144167 0.0658230927388317 0.156370780668007 0.0633863686022561 0.88981469561215 NA NA NA 0.793920905832004 99.727107917785 a10322 loss_cnaBRCA34 266 Zibotentan, ZD4054 Endothelin A Receptor 5 44 2.99573227355399 NA 5.71276746562642 5.74536573892078 -0.0325982732943588 0.217264826621981 0.514315037454414 0.0657211253290545 0.15003934967843 0.0633819175416355 0.8898417652285 NA NA NA 0.798295960820028 99.727107917785 a10323 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 201 Epothilone B Microtubules 15 33 -3.44201937618241 NA -4.28988617829947 -4.21115417317016 -0.0787320051293152 1.58292839098611 1.91157184056361 0.043310496120298 0.049738197620088 0.0411870500802637 0.889991425462611 NA NA NA 0.882174392991553 99.727107917785 a10324 loss_cnaBRCA20 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 39 1.38629436111989 0.693147180559945 3.35202970716782 3.43969133472272 -0.0876616275549083 0.430405560385342 1.07589651287193 0.0832445633265323 0.203672153948069 0.0814777504212832 0.890195520403757 NA NA NA 0.785238092315589 99.727107917785 a10325 PTEN_mut 312 AV-951 VEGFR 9 39 -2.05572501506252 NA 0.605324043058116 0.638495495807328 -0.0331714527492121 0.575941919628093 0.660228519965357 0.0513203986978684 0.0575951352362615 0.050242380851637 0.890230774360675 NA NA NA 0.881963594720565 99.727107917785 a10326 gain_cnaBRCA61_(NOTCH2) 276 CAY10603 HDAC6 3 46 2.99573227355399 NA 1.25293989556612 1.17049190951203 0.0824479860540885 1.15481687937539 0.991454566554884 0.0825346040370057 0.0713948570778448 0.0831586124421007 0.890430021254935 NA NA NA 0.914012193362526 99.727107917785 a10327 loss_cnaBRCA20 291 KIN001-266 MAP3K8 (COT) 3 46 2.99573227355399 NA 3.68660471629568 3.78463634544 -0.0980316291443195 1.37678658906128 1.17935021891849 0.0824890334035432 0.0712032132817036 0.0831234247229953 0.8904901255352 NA NA NA 0.914236327418981 99.727107917785 a10328 loss_cnaBRCA29_(MAP2K4) 1033 Vismodegib SMO 6 39 2.30258509299405 NA 4.80128009107456 4.75338910485224 0.0478909862223214 0.73091481616967 0.795835631636536 0.0607320986040981 0.0655219803496284 0.0601769816762785 0.890499330153699 NA NA NA 0.886844446111015 99.727107917785 a10329 BRCA2_mut 1005 Cisplatin DNA crosslinker 5 40 1.79175946922805 2.30258509299405 3.73968268644225 3.66138365972914 0.0782990267131165 1.47937756959891 1.15847089513631 0.0656885986300847 0.0529270068183778 0.0675882553820254 0.890504646027768 NA NA NA 0.91396705716224 99.727107917785 a10330 gain_cnaBRCA48 1050 ZM-447439 AURKB 3 36 1.38629436111989 0.693147180559945 2.98994793372337 2.87942209387872 0.110525839844655 0.136386297725277 1.36617106640397 0.0831576006503449 0.810388152534849 0.0809019035482729 0.890688453428447 NA NA NA 0.649240101799708 99.727107917785 a10331 gain_cnaBRCA16 62 BMS-536924 IGF1R 3 9 1.63315443905142 NA 3.08823982211567 3.18997067847666 -0.101730856360987 1.30661498167442 1.01974028003516 0.0939160646831346 0.0778583268887824 0.0997615357093469 0.890766751137806 NA NA NA 0.910260618661298 99.727107917785 a10332 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1371 PLX4720 (rescreen) BRAF 6 41 2.30258509299405 NA 4.7578916785853 4.69972134356255 0.0581703350227549 0.71548955122118 0.990269085906146 0.0603667681030839 0.0813014458750253 0.0587419478711952 0.890771794091858 NA NA NA 0.864605852668252 99.727107917785 a10333 TP53_mut 1011 ABT-263 BCL2, BCL2L1, BCL2L2 34 9 0.693147180559945 NA 1.66368259755549 1.75094595711337 -0.0872633595578767 1.56078374095435 2.12174205775125 0.0517893218117311 0.0559099619429139 0.0411281659988224 0.89079420351776 NA NA NA 0.910327914480739 99.727107917785 a10334 gain_cnaBRCA12_(TERT) 1039 SL 0101-1 RSK, AURKB, PIM3 9 34 2.30258509299405 NA 4.6090153056956 4.65936710860117 -0.0503518029055785 1.25672883639244 0.889707671342195 0.0517882794925862 0.0400657655394606 0.0565936481469456 0.890796387125989 NA NA NA 0.912266851742113 99.727107917785 a10335 loss_cnaBRCA17 1009 ATRA Retinoic acid and retinoid X receptor agonist 8 37 2.30258509299405 NA 4.15747749709904 4.09483430390728 0.0626431931917626 1.20063972522898 1.15974402339312 0.0537018755146863 0.0521748463551925 0.0540146721416027 0.891096615131945 NA NA NA 0.895577456907032 99.727107917785 a10336 loss_cnaBRCA29_(MAP2K4) 228 KIN001-102 AKT1 7 42 2.32630161961136 NA 1.87545226088073 1.95507881849668 -0.0796265576159449 0.992359997010874 1.46878070096637 0.0561973704406181 0.0802395883104833 0.054212693265615 0.891101221976778 NA NA NA 0.859133201216919 99.727107917785 a10337 gain_cnaBRCA12_(TERT) 1031 Elesclomol HSP70 10 34 -1.6094379124341 NA -3.04644702047827 -2.95732379118618 -0.08912322929209 2.24951031460425 1.65594450100919 0.0495213318960927 0.0396189467163075 0.05382017889958 0.891167563888236 NA NA NA 0.90929253616066 99.727107917785 a10338 gain_cnaBRCA13_(FGFR1,WHSC1L1) 38 AZD-0530 SRC, ABL1 4 10 0.693147180559945 NA 2.62622864785134 2.57058251882044 0.0556461290309018 0.776288735126442 0.634888502626105 0.0826800833490006 0.0716822575324866 0.0876470888994389 0.891171939101005 NA NA NA 0.903931409582839 99.727107917785 a10339 gain_cnaBRCA14_(RAD21) 1170 CCT018159 HSP90 20 23 2.30258509299405 NA 3.36981102924331 3.31936526331178 0.0504457659315203 1.26906588699378 1.13915645533865 0.0419994077895973 0.0397503127682508 0.0442834394653224 0.891411745035907 NA NA NA 0.892279792967814 99.727107917785 a10340 gain_cnaBRCA47_(EGFR) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 6 37 -1.38629436111989 0.693147180559945 -2.17056289708488 -2.22861086691142 0.0580479698265384 0.490352414914443 1.00842452532141 0.0604460438291803 0.118380103902755 0.057563028634232 0.891431049512809 NA NA NA 0.82666267896937 99.727107917785 a10341 loss_cnaBRCA36_(FAT1,IRF2) 152 CP466722 ATM 9 40 2.77258872223978 NA 2.68596604666769 2.74008129632939 -0.0541152496616926 1.25427957181822 1.02687479620779 0.0506221344802693 0.0431444877821349 0.052698975436478 0.891448953754968 NA NA NA 0.906232419615876 99.727107917785 a10342 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 178 BAY 61-3606 SYK 6 42 2.07944154167984 NA 3.18034029452714 3.0836688969651 0.0966713975620483 1.93755990167694 1.5750514943356 0.0597329667350095 0.0498933723176147 0.0613766584201914 0.891734454128541 NA NA NA 0.910823337797851 99.727107917785 a10343 loss_cnaBRCA38 167 OSU-03012 PDPK1 (PDK1) 4 44 2.77258872223978 NA 2.16983749196145 2.25508280355002 -0.0852453115885763 0.293359453851796 1.2312733758386 0.0714664814338087 0.290583141157748 0.0692334564048519 0.891748230855344 NA NA NA 0.722987079104176 99.727107917785 a10344 CDH1_mut 1032 Afatinib ERBB2, EGFR 4 41 -0.693147180559945 NA 0.411021850361971 0.278710707959351 0.132311142402619 1.58968929676754 1.86409679381882 0.0716637930981282 0.0832308191743251 0.0709786867513271 0.891820129443845 NA NA NA 0.883635342800339 99.727107917785 a10345 gain_cnaBRCA48 186 Bexarotene Retinioic acid X family agonist 5 42 2.07944154167984 NA 3.67070603824064 3.59651253651336 0.074193501727279 0.654959277114194 1.18594844032116 0.0645873170691358 0.113279564577178 0.0625604783519824 0.892016275765664 NA NA NA 0.835544185611174 99.727107917785 a10346 NF1_mut 1375 Temozolomide DNA akylating agent 5 41 3.40119738166216 NA 5.85958229852928 5.9050702813784 -0.0454879828491261 0.802348289884254 0.692770639895332 0.0646652389833212 0.0566935624125132 0.0656609564978082 0.892039722818038 NA NA NA 0.908354933409198 99.727107917785 a10347 loss_cnaBRCA36_(FAT1,IRF2) 230 GSK429286A ROCK2 9 40 2.99573227355399 2.32630161961136 5.442634026923 5.39714923681129 0.0454847901117121 0.422190277732456 0.973252478949784 0.0503423028346369 0.107735285511563 0.0467348309873239 0.89204520429573 NA NA NA 0.828821827666252 99.727107917785 a10348 gain_cnaBRCA12_(TERT) 1053 MK-2206 AKT1, AKT2 9 33 1.38629436111989 0.693147180559945 1.3270147091881 1.41211478293306 -0.0851000737449608 1.63550814932627 1.66448996581384 0.0513042283673119 0.0520328032483462 0.0511268169185699 0.892166484397142 NA NA NA 0.892495523812227 99.727107917785 a10349 ARID1A_mut 1264 SGC0946 Q8TEK3 (DOT1L) 5 41 -0.693147180559945 NA 1.98592204043953 1.94641995879447 0.0395020816450564 0.556993785763034 0.61683762484182 0.0645839520969367 0.0709201478629459 0.0640396760090409 0.89217457521902 NA NA NA 0.887905917359241 99.727107917785 a10350 BRCA2_mut 1010 Gefitinib EGFR 5 40 -0.693147180559945 NA 1.46023449686183 1.3923557294058 0.0678787674560313 1.20836487352331 1.03227640096053 0.0646523977174759 0.0561740654195884 0.0657563879140027 0.892220872433234 NA NA NA 0.909199987407942 99.727107917785 a10351 gain_cnaBRCA63 197 Bryostatin 1 PRKC 6 42 -4.8283137373023 NA -2.85744765910526 -2.79956910365989 -0.0578785554453654 1.59940115765222 0.866853005911945 0.0594507366445397 0.0361876413359147 0.066768592887875 0.892242762546351 NA NA NA 0.933914273463043 99.727107917785 a10352 loss_cnaBRCA17 1072 BMS-708163 g-secretase 9 37 1.6094379124341 NA 3.64505273747023 3.69378418196513 -0.0487314444949019 0.889505395405735 0.977740103954828 0.0506406274746559 0.0547848779182208 0.0498408976964222 0.892243718689411 NA NA NA 0.887307363129086 99.727107917785 a10353 loss_cnaBRCA36_(FAT1,IRF2) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 8 37 2.30258509299405 NA 3.11956083274667 3.18925749615844 -0.0696966634117686 0.952710269010329 1.37163568485196 0.0530989154135824 0.0731562004513389 0.0508128099767913 0.892311615926536 NA NA NA 0.865920382274812 99.727107917785 a10354 MACF1_mut 1016 Temsirolimus MTOR 3 41 -1.6094379124341 NA -1.86560307358243 -1.74255104830062 -0.123052025281809 1.81821070739707 1.4935458795743 0.081459620581274 0.0676775385719561 0.0823891833285244 0.892316019889626 NA NA NA 0.918489281801134 99.727107917785 a10355 ARID1A_mut 1042 BIRB 0796 p38, JNK2 4 39 2.30258509299405 NA 4.42698761325521 4.36040149731159 0.0665861159436218 0.693347942412319 0.94772336380716 0.0714850549550622 0.0960356436797855 0.0702590212360435 0.892362696165714 NA NA NA 0.868405310848951 99.727107917785 a10356 gain_cnaBRCA8_(CHD4,WNK1) 208 SB-715992 KIF11 4 45 -2.05572501506252 NA -1.12783250154791 -1.24986077530207 0.122028273754164 2.487569819801 1.65518657635 0.0709304798492321 0.0490552155693568 0.0737247845637194 0.892443432491652 NA NA NA 0.928980946413095 99.727107917785 a10357 loss_cnaBRCA7_(FAS,PTEN) 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 3 23 2.30258509299405 NA 2.59892709234741 2.70362288875931 -0.104695796411902 0.286814774277028 1.30183791738299 0.0838128344629883 0.365029300445934 0.0804215294499687 0.892536143589154 NA NA NA 0.746123260044028 99.727107917785 a10358 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1495 AZD-2281 PARP1, PARP2 6 39 2.30258509299405 NA 4.05749539098152 3.98964451325898 0.0678508777225413 1.47676580870806 1.08654214711914 0.0595806149603559 0.0459455909139042 0.0624466136932111 0.892562306827471 NA NA NA 0.917497861012388 99.727107917785 a10359 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 104 Bortezomib Proteasome 3 11 -3.91202300542815 NA -4.44376949052587 -4.60679039273521 0.163020902209346 1.29481264574335 1.9050265510919 0.0896898531306757 0.125903081612055 0.0855740840545805 0.892760496219362 NA NA NA 0.86986871365015 99.727107917785 a10360 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 226 GSK1070916 AURKB 9 40 0.940007258491471 2.32630161961136 2.32390728375821 2.42195680493573 -0.0980495211775207 1.04632941714183 2.10099674522461 0.0499759457661466 0.093708080429732 0.0466680976067093 0.892825913835191 NA NA NA 0.840348684353809 99.727107917785 a10361 loss_cnaBRCA22_(SYNCRIP,ZNF292) 173 FH535 unknown 18 30 3.46573590279973 NA 1.605546798131 1.55346883343703 0.052077964693966 1.6459143404081 1.0246589708758 0.0403829587223239 0.031640750320611 0.0508246803806866 0.89284822123909 NA NA NA 0.904723166846104 99.727107917785 a10362 loss_cnaBRCA20 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 3 43 0 NA 0.49684394953011 0.664124763739438 -0.167280814209328 1.08084995430357 2.11123923741819 0.0805966546236434 0.154767841311622 0.0792334716239427 0.893252192731504 NA NA NA 0.826171637263473 99.727107917785 a10363 TP53_mut 164 JQ12 HDAC 37 10 1.63315443905142 NA 1.56096171056035 1.64049257607238 -0.0795308655120386 1.65165171518285 1.66252216508412 0.0480888557829983 0.0481523221760066 0.0478374768062203 0.893271916326069 NA NA NA 0.89496828861557 99.727107917785 a10364 loss_cnaBRCA20 1003 Camptothecin TOP1 3 42 -2.30258509299405 NA -2.64945334527139 -2.52069773679783 -0.128755608473561 1.48346160342351 1.60653173650095 0.0804211208216837 0.0867940283566631 0.0801450762211474 0.893579568617685 NA NA NA 0.89664520334466 99.727107917785 a10365 gain_cnaBRCA10_(MDM2,NUP107) 1199 Tamoxifen ER 3 44 1.6094379124341 NA 3.79709268687962 3.87408459970791 -0.0769919128282872 0.758297213273447 0.968677443605658 0.0801743205135169 0.101532633221643 0.0794814758375133 0.893716244808727 NA NA NA 0.880206633163058 99.727107917785 a10366 gain_cnaBRCA61_(NOTCH2) 291 KIN001-266 MAP3K8 (COT) 3 46 2.99573227355399 NA 3.68935066898962 3.78445726156865 -0.0951065925790382 1.66407287704011 1.16278792217036 0.080026792801917 0.0571529011086369 0.0817918648497141 0.893738594482433 NA NA NA 0.930772026446152 99.727107917785 a10367 gain_cnaBRCA61_(NOTCH2) 184 BMS-754807 IGF1R 3 45 0.940007258491471 NA 1.7537668141492 1.61840909738192 0.135357716767281 2.02022999361497 1.67449802070475 0.0800459432987739 0.0670011420457501 0.0808348024862477 0.89379753469469 NA NA NA 0.919220204960394 99.727107917785 a10368 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1241 CHIR-99021 GSK3B 8 38 2.30258509299405 NA 4.27399305107324 4.22253846962667 0.0514545814465714 0.573822585757902 1.04498135891726 0.052226844629104 0.0896698434736765 0.0492397122757149 0.893808017998281 NA NA NA 0.84780963848001 99.727107917785 a10369 POLR2B_mut 1375 Temozolomide DNA akylating agent 3 43 3.40119738166216 NA 5.9527846382567 5.89645207242769 0.0563325658290044 0.618008036436623 0.707254107845869 0.0800811920719626 0.0911518338075548 0.0796496834787997 0.893930719244949 NA NA NA 0.891734518932923 99.727107917785 a10370 gain_cnaBRCA64_(SDHC) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 9 38 2.99573227355399 NA 3.78985546074755 3.86135346754089 -0.0714980067933348 1.33800560569347 1.459165691351 0.0497075831677532 0.0534362535471428 0.0489992378638896 0.893931661617264 NA NA NA 0.889578920661774 99.727107917785 a10371 gain_cnaBRCA48 294 MPS-1-IN-1 MPS1 5 44 2.99573227355399 NA 4.82354932417795 4.74890047326967 0.0746488509082859 0.942545381183226 1.20061963997115 0.0632160010158718 0.0791992114104632 0.0621752705212113 0.894014634394434 NA NA NA 0.876451694096893 99.727107917785 a10372 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1022 AZD7762 CHEK1, CHEK2 5 40 0.693147180559945 NA 0.997086301889731 0.893208733584503 0.103877568305229 0.810421920127943 1.69765084888463 0.0635123631222199 0.128177145416833 0.0611890061925731 0.894109678860485 NA NA NA 0.822824732670671 99.727107917785 a10373 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1192 GSK269962A ROCK1, ROCK2 15 31 1.6094379124341 NA 2.62609173179287 2.68819456052371 -0.0621028287308398 1.031253277649 1.64148675390887 0.0421045738841084 0.0602207334287642 0.0378332804592875 0.894117377350541 NA NA NA 0.876546855879196 99.727107917785 a10374 BRCA1_mut 167 OSU-03012 PDPK1 (PDK1) 4 44 2.77258872223978 NA 2.17158436508196 2.2549239969027 -0.0833396318207367 0.705003556908075 1.21958565846045 0.0698682020077838 0.118211647308899 0.0683343816341204 0.894154290679222 NA NA NA 0.842516765308408 99.727107917785 a10375 ARID1A_mut 1007 Docetaxel Microtubules 5 40 -4.38202663467388 NA -4.49953900721143 -4.59824723656662 0.0987082293551831 1.44393897107386 1.56661593194097 0.0634529760347831 0.0683603887231977 0.0630072931997363 0.894208088370552 NA NA NA 0.891827158636259 99.727107917785 a10376 gain_cnaBRCA15 238 CAL-101 PI3Kdelta 22 27 2.99573227355399 2.32630161961136 4.69887027853842 4.73533706016015 -0.0364667816217317 0.857072718519325 1.02277431947432 0.038293080093259 0.0425480601981259 0.0356547685323922 0.894504643814919 NA NA NA 0.892576977061625 99.727107917785 a10377 gain_cnaBRCA48 261 TL-1-85 MAP3K7 (TAK1) 5 44 2.32630161961136 NA 3.95586727142923 4.03264046531924 -0.0767731938900096 1.5048126919858 1.19083716944015 0.0628924237976353 0.0510184385730406 0.0644699341439795 0.894553851225748 NA NA NA 0.916887692306456 99.727107917785 a10378 loss_cnaBRCA38 201 Epothilone B Microtubules 4 44 -3.44201937618241 NA -4.11980569528 -4.24629903654517 0.126493341265168 1.64461960900782 1.82935766844016 0.0695828164461402 0.0769134337036635 0.069146314822637 0.894584018429814 NA NA NA 0.891622668172029 99.727107917785 a10379 PIK3CA_mut 184 BMS-754807 IGF1R 17 31 0.940007258491471 NA 1.58296294154206 1.65094644575545 -0.0679835042133956 2.04599181731322 1.46696562450077 0.0402030085809853 0.0332276520551636 0.0463429429278763 0.894606809565472 NA NA NA 0.904647816717129 99.727107917785 a10380 ARID1A_mut 1114 Cetuximab EGFR 5 40 4.18661983833127 NA 6.33228047804331 6.2763731272693 0.0559073507740093 0.764754129784634 0.89606197880613 0.0631957236704325 0.0731050001518183 0.0623922809987961 0.89463439710512 NA NA NA 0.885367838828286 99.727107917785 a10381 gain_cnaBRCA10_(MDM2,NUP107) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 3 44 -2.30258509299405 NA -0.0628968016963679 -0.145904156670677 0.0830073549743089 1.33362841879568 1.02961676582715 0.0794322581463553 0.0622417412559849 0.0806196613432422 0.894694014278961 NA NA NA 0.924820639110783 99.727107917785 a10382 loss_cnaBRCA34 202 GSK-1904529A IGF1R 5 43 0.0237165266173161 NA 2.23689284874888 2.18418391050192 0.0527089382469614 0.443128745509824 0.867343255989107 0.0628225287565853 0.118947233238772 0.0607705633069722 0.894806641282682 NA NA NA 0.83032533767857 99.727107917785 a10383 loss_cnaBRCA20 330 XMD13-2 RIPK 3 45 2.32630161961136 NA 3.62996082841969 3.72709193871971 -0.0971311103000194 0.488132361050511 1.24876667118661 0.0792550046486889 0.198985189367456 0.0777816325028298 0.894840598679951 NA NA NA 0.787651979798778 99.727107917785 a10384 gain_cnaBRCA12_(TERT) 298 OSI-930 KIT, VEGFR, PDGFR 9 39 2.32630161961136 NA 3.94852290246952 3.90525446428208 0.0432684381874364 0.683347714877717 0.916422063948076 0.0491501738547819 0.0633183330322238 0.047214531261971 0.89484420009882 NA NA NA 0.875196263331804 99.727107917785 a10385 CDH1_mut 1006 Cytarabine DNA synthesis 4 41 0.693147180559945 NA 1.30627600052054 1.19899739911333 0.107278601407206 1.47242214521535 1.54549029279906 0.0696385942853075 0.0728585900149684 0.0694139600274755 0.8948586145984 NA NA NA 0.897120975497763 99.727107917785 a10386 BRCA1_mut 166 FTI-277 Farnesyl transferase (FNTA) 4 43 0.0237165266173161 NA 2.29656997748666 2.23953377088612 0.0570362066005403 0.663133811887864 0.831352062754831 0.0694538420408025 0.0860101016990296 0.0686065617153109 0.894892276362199 NA NA NA 0.880259067820386 99.727107917785 a10387 gain_cnaBRCA8_(CHD4,WNK1) 1023 GW 441756 NTRK1 3 42 0.693147180559945 NA 2.4564707547322 2.35234507919204 0.104125675540164 0.896722674799235 1.32890808031948 0.0793660682211433 0.116118035671928 0.0783543098896141 0.894967276416702 NA NA NA 0.864941241832157 99.727107917785 a10388 gain_cnaBRCA16 158 PF-562271 FAK 15 30 0.940007258491471 NA 2.29690763693116 2.35142148986502 -0.0545138529338596 1.50354023373824 1.18785239300227 0.0419632883141349 0.0362569964611604 0.0458927836951837 0.895050028976235 NA NA NA 0.903495245555459 99.727107917785 a10389 gain_cnaBRCA15 1052 RO-3306 CDK1 20 23 1.6094379124341 NA 3.49940521847074 3.54851522341915 -0.0491100049484183 1.1986453769727 1.22192140704198 0.0405468851821736 0.0409712546278288 0.0401908049612647 0.895144303632229 NA NA NA 0.895010938534867 99.727107917785 a10390 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1053 MK-2206 AKT1, AKT2 5 37 1.38629436111989 0.693147180559945 1.30159361270894 1.40635005826863 -0.104756445559688 2.24642464538438 1.58002402896404 0.0631536283971547 0.0466325214936217 0.0663005395103852 0.895218678858938 NA NA NA 0.923882302909964 99.727107917785 a10391 gain_cnaBRCA8_(CHD4,WNK1) 279 BIX02189 MAP2K5 (MEK5) 4 45 2.99573227355399 NA 4.96987603823027 5.03246537843991 -0.0625893402096347 0.871806613426736 0.908836169186037 0.069043698840129 0.0717926880178393 0.0688675718811789 0.895287239062891 NA NA NA 0.89824989763846 99.727107917785 a10392 TP53_mut 175 PAC-1 CASP3 agonist 38 10 0.940007258491471 NA 2.41345122101566 2.35551800275341 0.0579332182622516 1.25261081267276 1.1416567658164 0.0470355843472777 0.0462499745939734 0.0507448648288119 0.895290985534189 NA NA NA 0.890618135217781 99.727107917785 a10393 gain_cnaBRCA13_(FGFR1,WHSC1L1) 88 MS-275 HDAC 4 10 1.6094379124341 NA 1.24280789694929 1.0977181128374 0.145089784111896 2.27249983997609 1.653520384718 0.079369863085128 0.0638458940940662 0.087745990586406 0.895500224094119 NA NA NA 0.912825356052894 99.727107917785 a10394 gain_cnaBRCA61_(NOTCH2) 279 BIX02189 MAP2K5 (MEK5) 3 46 2.99573227355399 NA 4.96040217492483 5.03172260125962 -0.0713204263347844 1.67792236784996 0.856253057119579 0.0786750887057525 0.0425052003008771 0.0832936311780365 0.895522703112928 NA NA NA 0.948251436924648 99.727107917785 a10395 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 3 23 2.30258509299405 NA 4.61322049519753 4.69525758958711 -0.082037094389583 0.871457830258709 1.01844666754976 0.0814654190115989 0.0941377672459821 0.0805511933059322 0.895527354803748 NA NA NA 0.89086087916248 99.727107917785 a10396 loss_cnaBRCA29_(MAP2K4) 201 Epothilone B Microtubules 7 41 -3.44201937618241 NA -4.15196313312597 -4.25006435261526 0.0981012194892905 1.54123532033357 1.85583294534167 0.0539643731162818 0.0636510325159551 0.0528610184098382 0.895594987446704 NA NA NA 0.8833898380845 99.727107917785 a10397 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 203 BMS-345541 IKBKB 6 43 2.77258872223978 NA 3.58345244130359 3.52519908089794 0.0582533604056472 0.638213718741833 1.0514351938046 0.0573642371993326 0.0912756318063597 0.0554036622978716 0.895839263452092 NA NA NA 0.8530593275078 99.727107917785 a10398 gain_cnaBRCA14_(RAD21) 225 Genentech Cpd 10 AURKA, AURKB 21 28 2.32630161961136 NA 3.0532891972806 2.99164413409277 0.0616450631878269 1.66908348302264 1.59232067429147 0.0379254144642136 0.0369334810480483 0.0387139752583171 0.89603746735445 NA NA NA 0.896809307423624 99.727107917785 a10399 PTEN_mut 286 KIN001-236 TIE2 9 40 2.32630161961136 NA 4.57062041931906 4.53323779456677 0.0373826247522935 0.715902610802652 0.783701532882146 0.0483866373694609 0.0522174723044815 0.0477000786444999 0.896213972937809 NA NA NA 0.891608489468871 99.727107917785 a10400 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 6 41 2.99573227355399 NA 3.91954740841891 3.83714259665289 0.0824048117660285 1.74098752125464 1.39595511181875 0.0572898154326906 0.0473322242462965 0.0590311329270937 0.896305882498412 NA NA NA 0.915368496464748 99.727107917785 a10401 loss_cnaBRCA38 156 AZD6482 PI3Kbeta 4 43 1.63315443905142 NA 2.14559172056845 2.04472543742523 0.100866283143213 1.14644823407792 1.49347183402417 0.0684822183182036 0.087981541725989 0.0675381221428385 0.896354041841892 NA NA NA 0.878004427442304 99.727107917785 a10402 gain_cnaBRCA10_(MDM2,NUP107) 276 CAY10603 HDAC6 5 44 2.99573227355399 NA 1.23092297724557 1.16924619631873 0.0616767809268368 0.647732013288966 1.02554851185533 0.0617402178955773 0.0952195964711745 0.0601402861140686 0.89647432143839 NA NA NA 0.856686044399107 99.727107917785 a10403 loss_cnaBRCA28_(GPS2) 1243 piperlongumine Increases ROS levels 4 43 2.30258509299405 NA 1.76403279132343 1.70524385931615 0.0587889320072716 0.524349347888354 0.879095785179189 0.0683583796285185 0.112117869973568 0.0668743190428202 0.896540377987279 NA NA NA 0.850017536998534 99.727107917785 a10404 loss_cnaBRCA33 1023 GW 441756 NTRK1 5 40 0.693147180559945 NA 2.28699938053007 2.3683227171903 -0.0813233366602306 1.21808174595726 1.32122863804624 0.0619853978033672 0.0667634474698747 0.0615512972686447 0.896640523374349 NA NA NA 0.894331714103843 99.727107917785 a10405 loss_cnaBRCA57 190 Bleomycin DNA damage 5 43 4.15888308335967 NA 1.92566510285747 2.09615892998895 -0.170493827131482 2.23420080453234 2.80907462508465 0.0616873796381148 0.0763108789441018 0.0606939472554398 0.896696287560391 NA NA NA 0.88089046258156 99.727107917785 a10406 POLR2B_mut 135 Gemcitabine DNA replication 3 44 0.0237165266173161 NA -0.0721592164614418 -0.289069037457873 0.216909820996432 1.44098345118503 2.83129386202283 0.0779050792748549 0.150529016011982 0.0766115534335455 0.896706801797567 NA NA NA 0.830686895165563 99.727107917785 a10407 loss_cnaBRCA7_(FAS,PTEN) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 4 39 1.6094379124341 NA 3.04023291182271 2.93623210363974 0.104000808182974 0.619633383704645 1.56698100993098 0.0685186675116623 0.167842487054485 0.0663701777646651 0.896802807677429 NA NA NA 0.800823587077676 99.727107917785 a10408 loss_cnaBRCA17 83 JW-7-52-1 MTOR 3 9 0.182321556793955 NA -2.17008593323096 -1.96985845091439 -0.200227482316568 0.696637418523646 2.50276072386981 0.088591810554444 0.287419936099473 0.0800026468399156 0.896918210529427 NA NA NA 0.8331861669481 99.727107917785 a10409 CDH1_mut 173 FH535 unknown 4 44 3.46573590279973 NA 1.49267216351374 1.58030042535032 -0.0876282618365722 1.15592382836657 1.29843652655724 0.0679487766534225 0.0758079898399526 0.0674875206021166 0.897045133634816 NA NA NA 0.893244630753 99.727107917785 a10410 ARID1A_mut 224 AS605240 PI3Kgamma 5 44 2.99573227355399 2.32630161961136 3.35801283957244 3.26028446634107 0.0977283732313676 1.24549648529401 1.62061466667322 0.0613819932888617 0.0784653946320031 0.0603032758132341 0.897071530115155 NA NA NA 0.877920779023926 99.727107917785 a10411 gain_cnaBRCA47_(EGFR) 1239 YK 4-279 RNA helicase A 6 36 2.30258509299405 NA 2.07773904953438 2.00285518525186 0.074883864282516 0.733342118215187 1.36793774621935 0.0573562468444481 0.102113137132733 0.0547421580327592 0.897161593274434 NA NA NA 0.845624581155303 99.727107917785 a10412 loss_cnaBRCA34 179 5-Fluorouracil DNA antimetabolite 5 44 3.46573590279973 NA 3.95173229836209 4.0516749141553 -0.0999426157932151 1.44058163776751 1.64648429168368 0.0613154814799729 0.0693765720546722 0.0607006190693835 0.897182420896615 NA NA NA 0.890281327100421 99.727107917785 a10413 loss_cnaBRCA22_(SYNCRIP,ZNF292) 221 TAK-715 p38a 19 30 2.99573227355399 2.32630161961136 4.50579915128157 4.46717663688452 0.0386225143970522 1.1606757042737 0.911032991885321 0.0380919188367333 0.0332758877047576 0.0423941994868106 0.897185058443446 NA NA NA 0.902867380269381 99.727107917785 a10414 loss_cnaBRCA7_(FAS,PTEN) 1008 Methotrexate Dihydrofolate reductase (DHFR) 4 41 -1.6094379124341 NA 0.614715533267375 0.689277834563763 -0.0745623012963885 0.890434531032191 1.11224733174839 0.0678933572634217 0.0837369831221123 0.0670375186957572 0.897478345549014 NA NA NA 0.883618387233853 99.727107917785 a10415 ARID1A_mut 1001 AICAR AAPK1 (AMPK) agonist 5 40 7.60090245954208 NA 7.66243274016856 7.74798961514112 -0.0855568749725544 1.0348618494547 1.423238908908 0.0614769405571027 0.082674682632891 0.0601142046054649 0.897483500822247 NA NA NA 0.873347876391892 99.727107917785 a10416 PIK3CA_mut 274 PXD101, Belinostat HDAC 17 31 2.99573227355399 NA 0.709548317723872 0.650639974356639 0.0589083433672332 2.02889420109031 1.13398636580581 0.0390950334091963 0.0290347043899954 0.0519480173162161 0.897494600579641 NA NA NA 0.912944028861645 99.727107917785 a10417 loss_cnaBRCA29_(MAP2K4) 185 OSI-906 IGF1R 7 41 0.940007258491471 NA 2.94488840847891 2.88471455964117 0.0601738488377377 0.91259540349905 1.16610876531382 0.0529580948990762 0.0659370500958263 0.0516022609790982 0.897530640113351 NA NA NA 0.88055926268186 99.727107917785 a10418 gain_cnaBRCA16 179 5-Fluorouracil DNA antimetabolite 16 33 3.46573590279973 NA 3.99823040201613 4.06244458431472 -0.0642141822985933 1.69502739051317 1.59857261063521 0.0393957767317269 0.0378838611446583 0.0401697000632814 0.897655616318777 NA NA NA 0.900102024525295 99.727107917785 a10419 gain_cnaBRCA58_(CCND1) 1042 BIRB 0796 p38, JNK2 8 35 2.30258509299405 NA 4.3282050913052 4.37537051764947 -0.0471654263442689 0.964784383981589 0.924486424172073 0.0506343890136208 0.0488870126085799 0.0510179761552562 0.897824627924218 NA NA NA 0.902415999286094 99.727107917785 a10420 gain_cnaBRCA48 179 5-Fluorouracil DNA antimetabolite 5 44 3.46573590279973 NA 3.95229922350881 4.05161049084318 -0.0993112673343663 2.11737431483416 1.57699834947582 0.0609280070686626 0.0469030282641095 0.0629748708154175 0.897828472740313 NA NA NA 0.923335181227836 99.727107917785 a10421 gain_cnaBRCA16 56 WH-4-023 SRC family, ABL 3 9 1.63315443905142 NA 3.14684485640436 3.24876412557234 -0.101919269167973 1.09374173996116 1.17776509139771 0.0877519904404482 0.0931840355398638 0.0865361606591857 0.897889175422761 NA NA NA 0.898095251159788 99.727107917785 a10422 gain_cnaBRCA61_(NOTCH2) 258 STF-62247 stimulates autophagy 3 46 2.32630161961136 NA 4.56107955396867 4.63539268916995 -0.074313135201276 0.807197785670292 0.97483022213846 0.07674691026288 0.0920631058713409 0.0762318745496597 0.898068639821881 NA NA NA 0.890774925103913 99.727107917785 a10423 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 222 BX-912 PDPK1 (PDK1) 6 43 2.32630161961136 NA 3.95876138006144 3.87331837054075 0.0854430095206893 1.17007394116614 1.55938651610655 0.0561125048285901 0.0730235983510015 0.0547927076694379 0.898099193307951 NA NA NA 0.876887793069141 99.727107917785 a10424 gain_cnaBRCA62 274 PXD101, Belinostat HDAC 10 38 2.99573227355399 NA 0.726050926560198 0.657148719493675 0.0689022070665226 2.32997029290318 1.2256493088847 0.0457274349853157 0.0295721397291591 0.0562169019857902 0.898186530787794 NA NA NA 0.929784341871186 99.727107917785 a10425 gain_cnaBRCA9_(KRAS) 135 Gemcitabine DNA replication 4 43 0.0237165266173161 NA -0.104216070943825 -0.291131418924545 0.186915347980721 3.72882064128951 2.70424055376543 0.0671318869755654 0.050127202663221 0.069119349504783 0.898386159379995 NA NA NA 0.927668370406388 99.727107917785 a10426 gain_cnaBRCA12_(TERT) 275 I-BET BRD2, BRD3, BRD4 9 40 2.99573227355399 NA 3.98607272985114 4.05083643346493 -0.0647637036137891 1.79260874294037 1.26486300693797 0.0473026729619331 0.0361281868499419 0.051202148579372 0.898525873905944 NA NA NA 0.920195921177002 99.727107917785 a10427 ARID1A_mut 1008 Methotrexate Dihydrofolate reductase (DHFR) 5 40 -1.6094379124341 NA 0.742018554749408 0.675229014410919 0.0667895403384893 1.06687914785248 1.10139651482983 0.060815546301696 0.0626027235352099 0.0606407769038642 0.898580213516204 NA NA NA 0.900385464074493 99.727107917785 a10428 gain_cnaBRCA9_(KRAS) 1028 VX-702 p38 4 41 0.693147180559945 NA 3.46899299068877 3.4227181089869 0.0462748817018674 0.305642833724878 0.709655454063402 0.0671431694969341 0.151401821328229 0.0652075333697543 0.898604790727871 NA NA NA 0.813545749257059 99.727107917785 a10429 loss_cnaBRCA34 1003 Camptothecin TOP1 5 40 -2.30258509299405 NA -2.61580479662343 -2.51846602495514 -0.0973387716682907 1.67898453787836 1.59283959800702 0.0607968866812264 0.0579747874219808 0.0611102158623395 0.898611157500216 NA NA NA 0.907020868431762 99.727107917785 a10430 PIK3CA_mut 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 14 28 1.38629436111989 0.693147180559945 3.46288519353015 3.41870208808099 0.044183105449159 0.930920977325247 1.10712725074812 0.0419553150278418 0.0474617142865417 0.0399078835963105 0.898652276782286 NA NA NA 0.892780939616319 99.727107917785 a10431 gain_cnaBRCA27_(CLTC,PPM1D) 1239 YK 4-279 RNA helicase A 8 34 2.30258509299405 NA 2.06673647344003 2.00103909349274 0.0656973799472853 1.31892672485385 1.30275634312364 0.0503196605976154 0.0498112432702167 0.0504295222157671 0.898746880192532 NA NA NA 0.901303682309589 99.727107917785 a10432 loss_cnaBRCA34 136 Mitomycin C DNA crosslinker 5 43 2.77258872223978 NA -0.0537335066486255 -0.14367409723641 0.089940590587784 0.296096325150926 1.55619943832774 0.0603805899087394 0.303754497938938 0.0577950283059043 0.898872407454474 NA NA NA 0.742609219704985 99.727107917785 a10433 TP53_mut 260 NG-25 MAP3K7 (TAK1) 38 11 2.32630161961136 NA 3.19563079430778 3.25225969503594 -0.0566289007281608 1.31485906876935 1.2164058397853 0.0437444599052788 0.0430684185653168 0.0465542821943013 0.898879763990899 NA NA NA 0.895354006357008 99.727107917785 a10434 loss_cnaBRCA60 268 YM155 BIRC5 (Survivin) 3 46 1.63315443905142 NA -3.48060627817434 -3.60307615787697 0.122469879702632 2.0067705296557 1.58992665604988 0.0760746301001158 0.0610283427491055 0.0770286347716849 0.898956564156532 NA NA NA 0.926284512547923 99.727107917785 a10435 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 13 13 2.30258509299405 NA 2.72298164591503 2.66010356320085 0.0628780827141817 1.03688125470653 1.43037426338397 0.0503339385903383 0.0606415463957617 0.0439591820992537 0.898959592232736 NA NA NA 0.899062391194527 99.727107917785 a10436 loss_cnaBRCA7_(FAS,PTEN) 257 NPK76-II-72-1 PLK3 4 45 2.32630161961136 NA 3.57653803538124 3.47028672032954 0.106251315051699 1.64271920267545 1.59299553728905 0.0665645107945218 0.0646801442867719 0.0666990663592925 0.899026044003151 NA NA NA 0.907865747669003 99.727107917785 a10437 gain_cnaBRCA63 193 GW-2580 CSF1R (cFMS) 7 41 2.99573227355399 NA 5.4968737229127 5.45767194099877 0.0392017819139259 0.973540814165828 0.711999379767649 0.0521789641567697 0.0402672197647056 0.0550587304257467 0.899029790713342 NA NA NA 0.921577037636762 99.727107917785 a10438 loss_cnaBRCA29_(MAP2K4) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 7 40 2.77258872223978 NA 5.05681635437733 5.00286638041107 0.0539499739662634 0.918472920022781 1.04897940827836 0.0522501690525575 0.0587387747533431 0.0514309180337571 0.899087874978494 NA NA NA 0.891576533155048 99.727107917785 a10439 gain_cnaBRCA15 265 Tubastatin A HDAC6 22 27 2.99573227355399 NA 4.67072917944559 4.70889530461932 -0.0381661251737304 1.13598561596334 0.960461699653141 0.0366085832340388 0.0335973665840521 0.039737269260725 0.899119147530101 NA NA NA 0.900917528275569 99.727107917785 a10440 gain_cnaBRCA10_(MDM2,NUP107) 274 PXD101, Belinostat HDAC 5 43 2.99573227355399 NA 0.590241321948659 0.680952418526008 -0.0907110965773487 0.695987691412064 1.56223273314932 0.0602008483927407 0.130334340242869 0.0580650338790965 0.899171782245164 NA NA NA 0.821772377626328 99.727107917785 a10441 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1052 RO-3306 CDK1 15 28 1.6094379124341 NA 3.55776104080956 3.50848353199685 0.0492775088127018 1.24661256194312 1.19244176266134 0.0406844777104132 0.0395291290309895 0.0413248766989863 0.899442598821043 NA NA NA 0.901103584225115 99.7409318758739 a10442 loss_cnaBRCA23 1261 rTRAIL TR10A (DR4), TR10B (DR5) 3 44 -2.30258509299405 NA -0.0664928510440521 -0.14565897148788 0.0791661204438281 0.758125853758581 1.05647647022893 0.0757551156948039 0.104423454300291 0.0749341066031253 0.899541567526092 NA NA NA 0.877546227035528 99.7409318758739 a10443 loss_cnaBRCA36_(FAT1,IRF2) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 9 37 0 NA 0.57444018901459 0.672376621304185 -0.0979364322895949 1.70331844146049 2.14956759051106 0.0471850919532565 0.057497429667714 0.0455609922302143 0.899554842024139 NA NA NA 0.885534031621142 99.7409318758739 a10444 TP53_mut 104 Bortezomib Proteasome 9 5 -3.91202300542815 NA -4.52525656768276 -4.65573873650403 0.130482168821268 1.77133065076675 1.90731230035045 0.0717807220197201 0.073663360798723 0.0684115384760498 0.899733435134931 NA NA NA 0.903068649987918 99.7511819746014 a10445 gain_cnaBRCA14_(RAD21) 6 PHA-665752 MET 6 8 0.693147180559945 NA 2.89542723292759 2.84111714935714 0.0543100835704502 1.07975699827943 0.465686951419913 0.0694070325462169 0.0502984316443351 0.116623588882735 0.899868743778133 NA NA NA 0.911649315637898 99.7544785814321 a10446 NF1_mut 276 CAY10603 HDAC6 5 44 2.99573227355399 NA 1.2290617235543 1.16945770242001 0.0596040211342879 0.590060295372213 1.02879372087055 0.0596646083171576 0.101013441510565 0.057935832932429 0.899935472201088 NA NA NA 0.851014441375524 99.7544785814321 a10447 gain_cnaBRCA9_(KRAS) 1061 SB590885 BRAF 4 38 1.6094379124341 NA 3.94641851665561 4.01880571533683 -0.0723871986812199 0.66912604087733 1.12477371410516 0.0659754630506323 0.108181709063824 0.064357121591172 0.900748230295835 NA NA NA 0.85679839388447 99.8046033833058 a10448 gain_cnaBRCA19 1009 ATRA Retinoic acid and retinoid X receptor agonist 4 41 2.30258509299405 NA 4.03612475695604 4.11278512667165 -0.0766603697156061 0.933871140300208 1.18214870174235 0.0657158556149472 0.0820888090523521 0.0648483305041213 0.900748557452766 NA NA NA 0.886038202796542 99.8046033833058 a10449 MACF1_mut 1053 MK-2206 AKT1, AKT2 3 39 1.38629436111989 0.693147180559945 1.50968165068361 1.38497116070341 0.124710489980197 1.79670477295128 1.6512160136371 0.0751814417800196 0.0694106743955195 0.0755264538075186 0.900771108574913 NA NA NA 0.916770803179814 99.8046033833058 a10450 BRCA2_mut 223 ZSTK474 PI3K 6 43 1.63315443905142 2.32630161961136 0.842490663388037 0.922084095929438 -0.0795934325414003 1.48789543856401 1.45460632846117 0.0545839488748401 0.0534939690508207 0.0547181948710495 0.900860067531984 NA NA NA 0.905811674137196 99.8046033833058 a10451 gain_cnaBRCA27_(CLTC,PPM1D) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 9 39 0.246860077931526 2.32630161961136 -0.202347507898575 -0.279399032162946 0.0770515242643717 1.84291611989005 1.62585058502996 0.0462595663476322 0.0418095666063025 0.0473915161539595 0.900994685212537 NA NA NA 0.910130929498699 99.8046033833058 a10452 loss_cnaBRCA29_(MAP2K4) 1248 FK866 NAMPT 6 38 0 NA -0.780578146603506 -0.630199721486521 -0.150378425116985 3.53768531686857 2.6087724452692 0.0549639655051734 0.0425075753346242 0.057643366093384 0.901027248442309 NA NA NA 0.923721635263346 99.8046033833058 a10453 ASH1L_mut 1005 Cisplatin DNA crosslinker 3 42 1.79175946922805 2.30258509299405 3.58696606644537 3.67602051481049 -0.0890544483651192 1.32066201085179 1.18538987347258 0.0747087262403657 0.0674316726258231 0.0751267159928031 0.901096983909792 NA NA NA 0.918964496789383 99.8046033833058 a10454 loss_cnaBRCA34 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 5 41 0 NA 0.762734070228135 0.639859178981598 0.122874891246537 1.3778971109465 2.13284532061539 0.0591999324879223 0.0891756650553772 0.0576107840821218 0.901113484159136 NA NA NA 0.865995407050422 99.8046033833058 a10455 BRCA1_mut 345 KIN001-270 CDK9 4 45 2.99573227355399 NA 5.14912584376213 5.10389464545795 0.0452311983041813 0.618895768948523 0.700221226846555 0.065051424342469 0.0730837090404207 0.0645955828958227 0.90130903678178 NA NA NA 0.89701829486019 99.8046033833058 a10456 loss_cnaBRCA28_(GPS2) 1495 AZD-2281 PARP1, PARP2 4 41 2.30258509299405 NA 3.93099015007739 4.00529628689463 -0.0743061368172375 1.02654188494114 1.14682653855736 0.0652468172684161 0.0723849049973231 0.0647928298822854 0.901453198198959 NA NA NA 0.89826219069908 99.8046033833058 a10457 loss_cnaBRCA57 1026 17-AAG HSP90 5 38 0 NA -0.80200575746394 -0.908601504536628 0.106595747072688 1.38943090841994 1.84028994264436 0.0591778309975864 0.0767189979917093 0.0579233438180496 0.901610720848542 NA NA NA 0.882164101163253 99.8046033833058 a10458 loss_cnaBRCA57 1261 rTRAIL TR10A (DR4), TR10B (DR5) 5 42 -2.30258509299405 NA -0.085686640482852 -0.14714381181392 0.0614571713310677 1.14657325550783 1.0345948117387 0.0588087519994051 0.0536007368354739 0.0594021646288607 0.901624228042592 NA NA NA 0.913515214278742 99.8046033833058 a10459 BRCA2_mut 287 KIN001-244 PDPK1 (PDK1) 6 43 2.99573227355399 NA 3.43298715469498 3.48440170053098 -0.0514145458360011 1.07462101084772 0.933616515005554 0.0541426464515666 0.0478443519315173 0.0550703045732811 0.901657378855688 NA NA NA 0.914820056591457 99.8046033833058 a10460 gain_cnaBRCA12_(TERT) 282 EKB-569 EGFR 9 38 0.916290731874155 2.99573227355399 1.65743744345412 1.55926929620439 0.0981681472497247 1.83180201200437 2.19137987388153 0.0460474270920511 0.0535910249068393 0.0447974120871349 0.901699276636444 NA NA NA 0.891476228406745 99.8046033833058 a10461 ARID1A_mut 175 PAC-1 CASP3 agonist 5 43 0.940007258491471 NA 2.3367493459027 2.40889720224688 -0.0721478563441753 1.06815911680891 1.2461757999963 0.05857498593407 0.0675441094953294 0.0578954079708411 0.901880462578222 NA NA NA 0.893523486093956 99.8046033833058 a10462 gain_cnaBRCA62 178 BAY 61-3606 SYK 9 39 2.07944154167984 NA 3.03554494736222 3.10964694649838 -0.0741019991361656 1.96087965035564 1.53667005721641 0.045785710270851 0.0377901821372494 0.0482224526912413 0.902003528009236 NA NA NA 0.917523868230723 99.8046033833058 a10463 loss_cnaBRCA29_(MAP2K4) 308 XL-880 MET 7 42 1.63315443905142 NA 1.77773107912206 1.85939555886266 -0.0816644797406088 1.86629533599236 1.57602338084378 0.0505354124524405 0.043757532993665 0.0518167945559836 0.902012612576545 NA NA NA 0.915718791004233 99.8046033833058 a10464 loss_cnaBRCA28_(GPS2) 172 Embelin XIAP 4 44 3.46573590279973 NA 3.05078754346279 2.98781441946331 0.0629731239994795 0.896593820912687 0.980218117771477 0.0645889446652059 0.0702359558259905 0.0642439910646099 0.902108746528911 NA NA NA 0.900833787325315 99.8046033833058 a10465 gain_cnaBRCA10_(MDM2,NUP107) 1010 Gefitinib EGFR 3 42 -0.693147180559945 NA 1.3275193560108 1.40506770458355 -0.0775483485727486 0.435084881319002 1.07094456281844 0.073859535034266 0.178237286337446 0.0724111697889031 0.902215306987999 NA NA NA 0.808997075378155 99.8046033833058 a10466 gain_cnaBRCA61_(NOTCH2) 277 ABT-869 VEGFR and PDGFR family 3 45 0.0237165266173161 NA 2.65803753673493 2.69328096200403 -0.0352434252691003 0.319996246597202 0.484953486677377 0.0735825818872226 0.110136995805027 0.0726738259179617 0.9023265972627 NA NA NA 0.87166450623038 99.8046033833058 a10467 MLL3_mut 1066 AZD6482 PI3Kbeta 3 40 1.6094379124341 NA 2.06683439123765 1.95971413148518 0.107120259752467 2.66102054280215 1.35957916308609 0.0738549142900736 0.040255329874179 0.0787892773447018 0.902411060067199 NA NA NA 0.951018627418208 99.8046033833058 a10468 gain_cnaBRCA31 1061 SB590885 BRAF 13 29 1.6094379124341 NA 4.04302371684643 3.99796492863511 0.0450587882113229 0.911644825560855 1.16772154942829 0.0410673662533711 0.04942581469006 0.0385869287360359 0.902692344143786 NA NA NA 0.893318777857197 99.8046033833058 a10469 gain_cnaBRCA8_(CHD4,WNK1) 1239 YK 4-279 RNA helicase A 3 39 2.30258509299405 NA 1.92418823414934 2.02042708368783 -0.0962388495384938 1.18218442347116 1.31179617721752 0.0737111565095835 0.0814076447191839 0.0733641789859671 0.902701565299585 NA NA NA 0.903292232607864 99.8046033833058 a10470 TP53_mut 201 Epothilone B Microtubules 38 10 -3.44201937618241 NA -4.21921623231975 -4.29861635609567 0.0794001237759225 1.6406407823665 2.41365852097022 0.0436760150365946 0.0483958003661192 0.0328961711385777 0.902730086731849 NA NA NA 0.923476080258587 99.8046033833058 a10471 gain_cnaBRCA16 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 15 30 2.30258509299405 NA 3.21083021030249 3.15988536217661 0.050944848125881 0.911497800906777 1.46755533872071 0.0388111358249337 0.055891356046279 0.0347140900119585 0.902891492058949 NA NA NA 0.887109439948468 99.8046033833058 a10472 loss_cnaBRCA20 1036 PLX4720 BRAF 3 40 2.30258509299405 NA 4.67948140206184 4.59040075004537 0.0890806520164693 0.289744446135769 1.24126424355517 0.0734806258737887 0.307445589396139 0.0717660663142352 0.902903084520621 NA NA NA 0.736722857181836 99.8046033833058 a10473 loss_cnaBRCA60 281 CH5424802 ALK 3 45 1.63315443905142 NA 3.50168123470025 3.58014351880378 -0.0784622841035332 0.890207746982771 1.08045170359817 0.0731322640644819 0.0881392959895818 0.0726198902202054 0.902921283569402 NA NA NA 0.895470994975002 99.8046033833058 a10474 loss_cnaBRCA18 155 AP-24534 ABL 15 32 -0.669430653942629 NA 1.41552938893171 1.45934274778067 -0.0438133588489638 1.16560003929727 1.13316052830432 0.0383201147032297 0.037588673105552 0.0386647414506457 0.903079058506986 NA NA NA 0.90444547794076 99.8046033833058 a10475 loss_cnaBRCA17 1243 piperlongumine Increases ROS levels 9 38 2.30258509299405 NA 1.74180947372172 1.70277189085244 0.0390375828692753 0.369453272199847 0.932772888638724 0.045390914988222 0.105663113055766 0.0418511122533226 0.90309358462483 NA NA NA 0.842607952553074 99.8046033833058 a10476 MACF1_mut 1011 ABT-263 BCL2, BCL2L1, BCL2L2 3 40 0.693147180559945 NA 1.79681797960546 1.67333169980227 0.123486279803194 2.86987525051728 1.60082587625448 0.0732833474629395 0.0430284486341128 0.0771391077786174 0.90316243433713 NA NA NA 0.947706789441721 99.8046033833058 a10477 gain_cnaBRCA64_(SDHC) 254 AC220 FLT3 8 40 0.0237165266173161 NA 2.18864447480465 2.23078538168086 -0.04214090687621 0.782237698507289 0.907775179797377 0.0473591829312302 0.0538722525859156 0.0464221844946413 0.9032092352501 NA NA NA 0.894832570674687 99.8046033833058 a10478 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 266 Zibotentan, ZD4054 Endothelin A Receptor 9 40 2.99573227355399 NA 5.72386435152953 5.74612876692202 -0.0222644153924856 0.240430232345684 0.53353801661027 0.0448849232740971 0.092602395194937 0.0417297637644234 0.903685673119024 NA NA NA 0.849619493491585 99.8046033833058 a10479 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 88 MS-275 HDAC 4 10 1.6094379124341 NA 1.23465172634752 1.10098058107811 0.133671145269407 2.04716092622783 1.74917200873703 0.0731151243951911 0.0652958658778793 0.0764196686213399 0.903688102048457 NA NA NA 0.913119170614023 99.8046033833058 a10480 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 8 37 2.30258509299405 NA 3.22803962214777 3.16580262277442 0.0622369993733476 0.613125978657349 1.40888497805437 0.0474136439676183 0.101507686087021 0.0441746489903634 0.903780245096508 NA NA NA 0.846012788426553 99.8046033833058 a10481 BRCA1_mut 1243 piperlongumine Increases ROS levels 4 43 2.30258509299405 NA 1.66025755811946 1.71489736938164 -0.0546398112621809 0.909991776715244 0.856352851988186 0.0635322363665383 0.0600442912345996 0.0638052540320549 0.9038066133832 NA NA NA 0.914396215155326 99.8046033833058 a10482 loss_cnaBRCA7_(FAS,PTEN) 290 KIN001-260 IKK 4 45 2.99573227355399 NA 4.98298473996024 5.04950375901614 -0.0665190190558995 0.822885517783585 1.06318413291341 0.0633821659398268 0.080836298146389 0.0625658500692814 0.90382864387759 NA NA NA 0.887470551883261 99.8046033833058 a10483 gain_cnaBRCA12_(TERT) 201 Epothilone B Microtubules 9 39 -3.44201937618241 NA -4.3020504577923 -4.22045964792248 -0.0815908098698213 1.61758619091881 1.85736979342245 0.0448808749190391 0.0504398531143969 0.0439281451430731 0.903930381360373 NA NA NA 0.896565898518749 99.8046033833058 a10484 gain_cnaBRCA27_(CLTC,PPM1D) 38 AZD-0530 SRC, ABL1 3 11 0.693147180559945 NA 2.54410048325361 2.59803984816808 -0.053939364914477 0.305770962948527 0.724611665099748 0.0801294805716515 0.176404470831186 0.0744389961029014 0.904125546363075 NA NA NA 0.852112467375547 99.8046033833058 a10485 loss_cnaBRCA17 231 FMK RSK 11 38 2.99573227355399 2.32630161961136 5.57003493008794 5.59478607736948 -0.0247511472815329 0.470922428932646 0.627609852985226 0.0414091320448179 0.0525588626934416 0.0394371553661947 0.904250556736587 NA NA NA 0.888671145954084 99.8046033833058 a10486 gain_cnaBRCA15 196 Phenformin AAPK1 (AMPK) agonist 22 26 8.29404964010203 NA 7.23664648813836 7.17270789597606 0.0639385921623044 2.20738066948186 1.42675004419614 0.0350343007851531 0.0289658204614579 0.0448141511699258 0.904265105853169 NA NA NA 0.9077055621932 99.8046033833058 a10487 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1007 Docetaxel Microtubules 6 39 -4.38202663467388 NA -4.51576952666034 -4.59828121381435 0.0825116871540148 1.55750423406508 1.55543001801017 0.0530392793176684 0.0529768621807591 0.0530475085337304 0.904295506157856 NA NA NA 0.907406761554267 99.8046033833058 a10488 gain_cnaBRCA62 157 JNK-9L JNK 9 38 1.63315443905142 NA 0.0173404180868589 0.0649636377642356 -0.0476232196773768 1.00830119669415 1.07538286017058 0.0447684920236779 0.0472311446555016 0.044284897445569 0.904415779117935 NA NA NA 0.901890536309929 99.8046033833058 a10489 gain_cnaBRCA9_(KRAS) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 41 2.30258509299405 NA 3.10119503263609 3.18424960705588 -0.0830545744197959 0.944548106067728 1.33616744520818 0.0632728288761982 0.0879304864265331 0.0621588070549463 0.904419614114892 NA NA NA 0.879525847509472 99.8046033833058 a10490 gain_cnaBRCA14_(RAD21) 170 Shikonin unknown 21 26 2.77258872223978 NA 0.0270372576171168 -0.015315618298347 0.0423528759154638 1.01367969458977 1.32336182464699 0.0354219075585019 0.0417813202153603 0.0320040030826501 0.904441453886662 NA NA NA 0.901712677973302 99.8046033833058 a10491 ARID1A_mut 157 JNK-9L JNK 5 42 1.63315443905142 NA 0.00160108371513238 0.0623018233154053 -0.0607007396002729 1.42933600866827 1.0211183702181 0.0570620702518227 0.0424677887019921 0.0594453506769329 0.904531417630677 NA NA NA 0.930500448471958 99.8046033833058 a10492 MLL3_mut 1050 ZM-447439 AURKB 3 36 1.38629436111989 0.693147180559945 2.97694320337139 2.88050582140805 0.0964373819633408 2.08619338018327 1.27240705191638 0.0725532238375479 0.0462264825875676 0.0757912979326044 0.904553535129947 NA NA NA 0.943949196055137 99.8046033833058 a10493 gain_cnaBRCA12_(TERT) 328 SNX-2112 HSP90 9 39 0.940007258491471 NA 0.342811979121035 0.434415643906706 -0.0916036647856711 0.882706941742255 2.22444642740671 0.0445754906605064 0.103775851818801 0.0411804319749179 0.904580831833686 NA NA NA 0.844030016648593 99.8046033833058 a10494 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 14 34 0.246860077931526 2.32630161961136 -0.219857588756545 -0.283520105377954 0.0636625166214089 1.76884775826378 1.62320366621232 0.0382207004882509 0.0359909530506442 0.0392202888316305 0.904722303862948 NA NA NA 0.908648414648352 99.8046033833058 a10495 gain_cnaBRCA47_(EGFR) 1371 PLX4720 (rescreen) BRAF 7 40 2.30258509299405 NA 4.66674051823323 4.71421853824859 -0.0474780200153679 0.473585170586375 1.01833858336 0.0492682014889593 0.100252336779428 0.046623019878825 0.904817853565327 NA NA NA 0.84590024284925 99.8046033833058 a10496 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1192 GSK269962A ROCK1, ROCK2 17 29 1.6094379124341 NA 2.70207452339302 2.64793587777403 0.0541386456189819 1.65145407101009 1.36400008987122 0.0367035523608214 0.0327824107066257 0.0396910865483104 0.904904999045627 NA NA NA 0.909842322917087 99.8046033833058 a10497 ARID1A_mut 291 KIN001-266 MAP3K8 (COT) 5 44 2.99573227355399 NA 3.71814880969315 3.78550777251503 -0.0673589628218765 0.849764396377211 1.21519824185211 0.0566765607419695 0.0792678101236614 0.055430431432499 0.904921578683663 NA NA NA 0.878347117298224 99.8046033833058 a10498 PIK3CA_mut 1091 BMS-536924 IGF1R 16 31 1.38629436111989 NA 2.99640889633849 3.03718264389434 -0.0407737475558556 1.26085785985762 1.01455153073474 0.0369734945787938 0.0323380999984089 0.0401889370038477 0.904929969268828 NA NA NA 0.911717806625026 99.8046033833058 a10499 gain_cnaBRCA58_(CCND1) 282 EKB-569 EGFR 10 37 0.916290731874155 2.99573227355399 1.50635208988717 1.5974499823779 -0.0910978924907222 2.43436540087746 2.04934244750477 0.0427305039936057 0.0374216181588378 0.044452254722797 0.905102438436888 NA NA NA 0.915369739476752 99.8046033833058 a10500 gain_cnaBRCA15 304 SB52334 ALK5 22 27 2.99573227355399 NA 4.27756468770139 4.32171379680682 -0.0441491091054367 1.3050543991468 1.2642348542858 0.0344206620818489 0.0338293247655421 0.0349216041274054 0.905117965759301 NA NA NA 0.905459565189573 99.8046033833058 a10501 loss_cnaBRCA60 177 GSK-650394 SGK3 3 44 2.77258872223978 NA 4.12881776119484 4.00664024646347 0.122177514731366 1.282072976357 1.72608843261408 0.0714987601099767 0.0952968489192653 0.070782882512186 0.905157522582181 NA NA NA 0.887855136339845 99.8046033833058 a10502 gain_cnaBRCA10_(MDM2,NUP107) 312 AV-951 VEGFR 5 43 -2.05572501506252 NA 0.665036090107459 0.62846651798771 0.0365695721197489 0.40053155294712 0.665086663512726 0.0565746892583401 0.0913025998842517 0.0549846721126579 0.905214564929163 NA NA NA 0.864089747076332 99.8046033833058 a10503 gain_cnaBRCA16 254 AC220 FLT3 16 32 0.0237165266173161 NA 2.20205662754326 2.23461453203061 -0.0325579044873501 0.815873935865945 0.923479116312843 0.0365892574139328 0.039905557778107 0.0352557019560371 0.905399610674308 NA NA NA 0.901563780008628 99.8146142145816 a10504 loss_cnaBRCA29_(MAP2K4) 310 YM201636 FYV1 7 42 1.63315443905142 NA 2.45744577554223 2.40753776850897 0.0499080070332516 1.15942182653656 1.0031191495139 0.0487191874880439 0.0430455990140684 0.0497528205472266 0.905516889959989 NA NA NA 0.91727270036884 99.8146142145816 a10505 gain_cnaBRCA48 150 Bicalutamide ANDR (androgen receptor) 5 43 0.0237165266173161 NA 2.73089499141365 2.76627294717818 -0.0353779557645297 0.543488036610999 0.635556768365464 0.0563265411846631 0.0650942677324312 0.0556645094906556 0.905628300724413 NA NA NA 0.897383850792472 99.8146142145816 a10506 gain_cnaBRCA61_(NOTCH2) 272 AR-42 HDAC 3 46 1.63315443905142 NA 0.24466918536466 0.135270757369948 0.109398427994712 0.734693151836429 1.56741508588325 0.0709838624260554 0.148903562965384 0.0697954415393834 0.905684431103985 NA NA NA 0.83395756407805 99.8146142145816 a10507 gain_cnaBRCA12_(TERT) 329 QL-XI-92 DDR1 9 39 2.32630161961136 NA 4.28745532424669 4.24546119987249 0.0419941243741961 0.478224520107891 1.02609434971117 0.0440330423593677 0.0878125704736386 0.0409261822619109 0.905736377539173 NA NA NA 0.855799793897064 99.8146142145816 a10508 loss_cnaBRCA17 1059 AZD8055 MTORC1/2 6 37 0.693147180559945 NA 0.0847324908518516 0.13784125950832 -0.0531087686564681 1.63314828159711 0.897466880742584 0.0522665718893369 0.0325192569804693 0.0591762991995034 0.906046314863205 NA NA NA 0.940759145567618 99.8162795892443 a10509 loss_cnaBRCA33 211 TL-2-105 CRAF 6 43 2.32630161961136 1.63315443905142 3.8578084759553 3.9144949356682 -0.0566864597128927 0.930604207165388 1.11430534117038 0.0517105174676759 0.0609136078221257 0.0508715677996783 0.906053378093701 NA NA NA 0.895407701968041 99.8162795892443 a10510 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 238 CAL-101 PI3Kdelta 15 34 2.99573227355399 2.32630161961136 4.74324583166621 4.70825174344635 0.0349940882198521 0.971694381939179 0.944016435631687 0.036745177749948 0.036013471797599 0.0370693633066206 0.906140162165462 NA NA NA 0.907598829516094 99.8162795892443 a10511 PTEN_mut 230 GSK429286A ROCK2 9 40 2.99573227355399 2.32630161961136 5.43774608043312 5.39824902477151 0.0394970556616041 0.637043125246018 0.949017023184105 0.0437129833349583 0.0620005994827287 0.0416189116703988 0.906188274468644 NA NA NA 0.88103996070087 99.8162795892443 a10512 loss_cnaBRCA29_(MAP2K4) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 38 1.38629436111989 0.693147180559945 3.49267898905318 3.4271930320915 0.0654859569616755 0.745198316060157 1.07423698848401 0.0621821466699605 0.0878772208019711 0.0609604376536049 0.906426739995121 NA NA NA 0.880494850946815 99.8162795892443 a10513 loss_cnaBRCA28_(GPS2) 255 CP724714 ERBB2 4 44 2.32630161961136 NA 3.89810189995601 3.79439330206173 0.103708597894275 1.09812568450437 1.71427057265599 0.061695119576227 0.0944414645406304 0.0604972164537568 0.906473346876002 NA NA NA 0.871779561870777 99.8162795892443 a10514 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 163 JQ1 BRD4 14 33 0.940007258491471 NA 0.354789082360771 0.299425449770041 0.0553636325907301 1.63761664949397 1.39515937329755 0.0376798193676608 0.0338074436455184 0.0396826582327112 0.906485955172357 NA NA NA 0.912957470035173 99.8162795892443 a10515 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 197 Bryostatin 1 PRKC 15 33 -4.8283137373023 NA -2.78219128599729 -2.81799148540569 0.035800199408405 1.00854909540579 0.957914270235123 0.0367708135367429 0.035496734439091 0.0373730724354046 0.906516483298594 NA NA NA 0.908722470085537 99.8162795892443 a10516 loss_cnaBRCA60 223 ZSTK474 PI3K 3 46 1.63315443905142 2.32630161961136 0.816044683195971 0.918617957732742 -0.10257327453677 1.0166904126448 1.47476937805626 0.0703418592840159 0.100889389002831 0.0695520778116248 0.906533397765179 NA NA NA 0.881793321306564 99.8162795892443 a10517 loss_cnaBRCA34 170 Shikonin unknown 5 42 2.77258872223978 NA -0.0559941160826569 0.0107034979670408 -0.0666976140496977 0.583773399571372 1.23930438328388 0.0557822582566011 0.114252574883798 0.0538185896453977 0.906662388137418 NA NA NA 0.841207252328624 99.8162795892443 a10518 gain_cnaBRCA15 177 GSK-650394 SGK3 22 25 2.77258872223978 NA 3.98312132386476 4.0419982001181 -0.0588768762533465 2.05650901396936 1.3321092247074 0.0344548004799535 0.0286295250122466 0.0441982347703351 0.906699739804535 NA NA NA 0.909288749601968 99.8162795892443 a10519 gain_cnaBRCA27_(CLTC,PPM1D) 261 TL-1-85 MAP3K7 (TAK1) 9 40 2.32630161961136 NA 4.06798489105093 4.01509132029335 0.0528935707575808 1.2395393139252 1.21686964921315 0.0433284637778405 0.0426719589797315 0.0434669159443519 0.907009601727037 NA NA NA 0.909575369973933 99.8252332601808 a10520 gain_cnaBRCA12_(TERT) 265 Tubastatin A HDAC6 9 40 2.99573227355399 NA 4.72862287990307 4.68346523133492 0.0451576485681491 0.85715179397796 1.07666848392901 0.043313651236818 0.0526833740364431 0.0419420176611452 0.907041243122729 NA NA NA 0.893888390092505 99.8252332601808 a10521 gain_cnaBRCA63 269 NSC-207895 MDM4 7 42 2.99573227355399 NA 4.554798058677 4.61213312296465 -0.05733506428765 1.1135033524869 1.20826428405354 0.0479155771619165 0.0514906974995608 0.0474524200080629 0.907068009598749 NA NA NA 0.903757252637438 99.8252332601808 a10522 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1378 Bleomycin (50 uM) DNA damage 18 30 3.91202300542815 NA 3.7711844067869 3.83763753700089 -0.0664531302139832 1.8061332597798 1.95297508320811 0.034974780559975 0.0367930383066447 0.0340266144639296 0.907125921378031 NA NA NA 0.905372402318934 99.8252332601808 a10523 loss_cnaBRCA28_(GPS2) 341 EX-527 SIRT1 4 45 2.99573227355399 NA 5.60481100166132 5.64503699320383 -0.0402259915425089 0.642470989920947 0.660455985925015 0.0610110855396663 0.0626113741687521 0.060906392552669 0.907409305830121 NA NA NA 0.91109941160719 99.8385936178782 a10524 gain_cnaBRCA12_(TERT) 207 AS601245 JNK 9 39 2.07944154167984 NA 2.311630215738 2.25571698178415 0.0559132339538579 1.13105245933945 1.32457536826099 0.0432429764939587 0.0494346955281916 0.0422121951635454 0.907419776521764 NA NA NA 0.899051739376384 99.8385936178782 a10525 PTEN_mut 300 CX-5461 RNA Pol I 9 40 2.32630161961136 NA 3.85190992842612 3.92596775030318 -0.0740578218770653 1.64725809058428 1.73506377912849 0.0430459957702317 0.0449582383600843 0.0426830545181827 0.907613014055491 NA NA NA 0.905908495017816 99.8483168962161 a10526 loss_cnaBRCA60 305 TPCA-1 IKK 3 46 2.99573227355399 NA 4.26905113500246 4.17240953287526 0.0966416021272023 1.03047571514469 1.40491698818693 0.0694744465231852 0.0937834834017732 0.0687881226718738 0.907680614603654 NA NA NA 0.889545075245533 99.8483168962161 a10527 NF1_mut 155 AP-24534 ABL 4 43 -0.669430653942629 NA 1.50896066604054 1.4394433976464 0.0695172683941399 1.17420369459995 1.14113582441994 0.0608003202110908 0.0592037554589916 0.0609193637659011 0.907923518121233 NA NA NA 0.915741270739878 99.8655496943645 a10528 loss_cnaBRCA18 197 Bryostatin 1 PRKC 16 32 -4.8283137373023 NA -2.78375166158912 -2.81833005384129 0.0345783922521612 0.774395350578367 1.05660336462414 0.0355156920944244 0.0446521175861088 0.0327259910481751 0.908162394961128 NA NA NA 0.898377328875047 99.8668402097459 a10529 ASH1L_mut 156 AZD6482 PI3Kbeta 3 44 1.63315443905142 NA 2.14867962474061 2.04680731403039 0.101872310710223 1.30275653866751 1.48038342271747 0.0691623870650768 0.0781975048188362 0.0688148145587993 0.908242303250501 NA NA NA 0.906904529062053 99.8668402097459 a10530 loss_cnaBRCA24 1529 MLN4924 NEDD8-activating enzyme 3 34 0 NA 0.479320704130715 0.359500087192584 0.119820616938131 0.880346074870899 1.75386938848221 0.0698265618458187 0.136106265886064 0.0683178677528683 0.908365589310167 NA NA NA 0.850116025945311 99.8668402097459 a10531 loss_cnaBRCA29_(MAP2K4) 1230 IOX2 EGLN1 7 40 -2.30258509299405 NA 0.222885056784052 0.254113802026197 -0.0312287452421458 0.632743004248695 0.662705710481564 0.0474032279419078 0.0493545484224295 0.0471230966448938 0.908404105699433 NA NA NA 0.907583567867388 99.8668402097459 a10532 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1371 PLX4720 (rescreen) BRAF 9 38 2.30258509299405 NA 4.67375863955808 4.71505519477773 -0.0412965552196489 0.958730807941868 0.964742287900425 0.0428531388760796 0.0430741923359085 0.0428057894191856 0.908486209069305 NA NA NA 0.90950673915183 99.8668402097459 a10533 ASH1L_mut 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 3 44 2.32630161961136 NA 1.51666200239972 1.41013679473738 0.106525207662339 0.897622445316371 1.56795140840825 0.0689773836513116 0.118674848448997 0.0679391000837717 0.90848663035544 NA NA NA 0.86391214743618 99.8668402097459 a10534 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1143 HG-5-88-01 EGFR, ADCK4 5 21 2.30258509299405 NA 4.48777333113961 4.54510174168387 -0.0573284105442609 1.39322473488165 0.890720162389897 0.057773110859357 0.0411479993923096 0.0643618646629067 0.908538988487316 NA NA NA 0.933548614157001 99.8668402097459 a10535 ASH1L_mut 1031 Elesclomol HSP70 3 41 -1.6094379124341 NA -2.86205794773601 -2.98603183565621 0.123973887920201 3.20442698503916 1.69937782814291 0.0688814426050956 0.0386883172869942 0.0729525158367403 0.908861525768602 NA NA NA 0.952933955668277 99.8749533002308 a10536 loss_cnaBRCA57 154 CHIR-99021 GSK3B 5 42 0.940007258491471 NA 3.23111216385444 3.28071360870885 -0.0496014448544133 1.18948883445202 0.88125746609102 0.0543351255674548 0.0416997986174994 0.0562848506401082 0.909072794618373 NA NA NA 0.93186786293378 99.8749533002308 a10537 gain_cnaBRCA64_(SDHC) 266 Zibotentan, ZD4054 Endothelin A Receptor 8 41 2.99573227355399 NA 5.76045801243321 5.73844550588246 0.0220125065507544 0.831915993194207 0.409881452784216 0.0443763122431548 0.026460011264161 0.0537045684824948 0.909082651459932 NA NA NA 0.943573515127589 99.8749533002308 a10538 gain_cnaBRCA9_(KRAS) 341 EX-527 SIRT1 4 45 2.99573227355399 NA 5.67801893083211 5.63852962172198 0.0394893091101371 0.402630691632672 0.673273567123917 0.0598934371645307 0.0980782387701432 0.0586526948901725 0.909097789108502 NA NA NA 0.86802297768273 99.8749533002308 a10539 loss_cnaBRCA33 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 6 42 2.77258872223978 NA -0.498608897729821 -0.427658387796824 -0.0709505099329976 0.737402015019898 1.48010726890355 0.0500234740119849 0.0962168647329816 0.0479360593813969 0.909246617502229 NA NA NA 0.854217753933606 99.8749533002308 a10540 gain_cnaBRCA19 224 AS605240 PI3Kgamma 4 45 2.99573227355399 2.32630161961136 3.18284912668968 3.27802631578023 -0.0951771890905557 0.549780010719065 1.63930922160913 0.0597772163830281 0.173118678807678 0.0580593263527982 0.909273393707319 NA NA NA 0.801496893306642 99.8749533002308 a10541 gain_cnaBRCA15 106 XMD8-85 MAP2K5 (ERK5) 6 7 2.07944154167984 NA 3.1800946796609 3.26173601086011 -0.0816413311992013 1.22156090289726 1.28904275581461 0.0648555624423505 0.0668336150948894 0.0633348512537182 0.909299058212426 NA NA NA 0.908918817358481 99.8749533002308 a10542 BRCA2_mut 1038 NU-7441 PRKDC (DNAPK) 5 38 0.693147180559945 NA 2.84700111919363 2.89889973889386 -0.0518986197002329 1.25910526582045 0.913424097152701 0.054476056908001 0.0412186503456605 0.0568176599041013 0.909391466874477 NA NA NA 0.932747928216981 99.8749533002308 a10543 loss_cnaBRCA20 283 GSK2126458 PI3K, MTOR 3 45 -2.05572501506252 0.0237165266173161 -2.95014340422957 -3.06237220399225 0.112228799762681 1.03763454752065 1.66860985461243 0.0681739328907764 0.108158310679653 0.0672588618918038 0.909472863236151 NA NA NA 0.874597448379299 99.8749533002308 a10544 loss_cnaBRCA23 224 AS605240 PI3Kgamma 3 46 2.99573227355399 2.32630161961136 3.1684399432501 3.27689697580693 -0.108457032556831 1.69884107324849 1.58729349422162 0.0681177446240533 0.0638417767645806 0.0683282788921252 0.909475349855457 NA NA NA 0.923241066102144 99.8749533002308 a10545 loss_cnaBRCA34 304 SB52334 ALK5 5 44 2.99573227355399 NA 4.23986165431753 4.30894062208243 -0.0690789677649075 1.2695395957218 1.28386517619755 0.0538563512343573 0.0544126138307899 0.0538054688651186 0.909631172006336 NA NA NA 0.912817883630921 99.8785170793048 a10546 loss_cnaBRCA34 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 4 39 1.6094379124341 NA 3.02840172288667 2.93744555891523 0.0909561639714411 1.27524580770401 1.53544634107254 0.0599215613863964 0.0713244171609563 0.0592376050783426 0.909689456634313 NA NA NA 0.900619109152741 99.8785170793048 a10547 gain_cnaBRCA10_(MDM2,NUP107) 1003 Camptothecin TOP1 3 42 -2.30258509299405 NA -2.42759895753617 -2.53654447877891 0.108945521242746 0.73362078669951 1.63167440290121 0.0680436140799273 0.148503863600814 0.0667691550771614 0.909879732830172 NA NA NA 0.836850091759714 99.8785170793048 a10548 BRCA2_mut 1039 SL 0101-1 RSK, AURKB, PIM3 5 38 2.30258509299405 NA 4.60231529004043 4.6549484998289 -0.0526332097884712 1.08002611114204 0.959969679251222 0.0541307211094527 0.0487332752842574 0.0548279918898326 0.909963311980001 NA NA NA 0.921532483747449 99.8785170793048 a10549 loss_cnaBRCA23 1248 FK866 NAMPT 3 41 0 NA -0.477277922481049 -0.663395720211358 0.186117797730308 2.30991065769438 2.75561120349982 0.0680246598379037 0.080573591498158 0.0675413851903076 0.909990126795103 NA NA NA 0.904521355348788 99.8785170793048 a10550 loss_cnaBRCA36_(FAT1,IRF2) 151 QS11 ARFGAP 9 39 2.32630161961136 NA 3.70965190107395 3.77217250622058 -0.0625206051466294 1.51025044640343 1.48791676501997 0.0419088091966997 0.0413975081388113 0.0420188861477008 0.910263467614175 NA NA NA 0.912498767884445 99.8785170793048 a10551 loss_cnaBRCA18 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 15 32 2.99573227355399 NA 3.88224537017928 3.83145157376852 0.0507937964107654 1.50401773531095 1.40784709635429 0.0353113307844146 0.0337720727743041 0.036079057549857 0.91065464679631 NA NA NA 0.913160079981264 99.8785170793048 a10552 gain_cnaBRCA62 272 AR-42 HDAC 10 39 1.63315443905142 NA 0.191001363638376 0.129396122018663 0.0616052416197126 2.48549408180263 1.21438171397703 0.0399723245032614 0.0247859136220645 0.0507297177737955 0.910693177304644 NA NA NA 0.940832971655405 99.8785170793048 a10553 loss_cnaBRCA29_(MAP2K4) 222 BX-912 PDPK1 (PDK1) 7 42 2.32630161961136 NA 3.9438182134782 3.87377454093508 0.0700436725431164 1.44561209759645 1.53373787556732 0.0459974853456825 0.0484526054116277 0.0456686071713576 0.910771756629463 NA NA NA 0.909116548293766 99.8785170793048 a10554 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1199 Tamoxifen ER 6 41 1.6094379124341 NA 3.82795322587433 3.87520197786685 -0.0472487519925222 0.475819399168203 1.00463202013946 0.049198804472086 0.0992997596884856 0.0470309038984874 0.910882257736252 NA NA NA 0.852850243708304 99.8785170793048 a10555 gain_cnaBRCA48 1248 FK866 NAMPT 5 39 0 NA -0.521050432589477 -0.667328362388755 0.146277929799278 1.4392270235631 2.83828898803043 0.0534633162618181 0.101636453043479 0.0515373629733118 0.9109232762074 NA NA NA 0.856950855374918 99.8785170793048 a10556 loss_cnaBRCA29_(MAP2K4) 167 OSU-03012 PDPK1 (PDK1) 7 41 2.77258872223978 NA 2.29476172731773 2.23999173738592 0.0547699899318164 1.03491041543952 1.21480572625772 0.0459140567283476 0.0529224453776086 0.0450853899911538 0.91109736517423 NA NA NA 0.902490945681937 99.8785170793048 a10557 gain_cnaBRCA63 1061 SB590885 BRAF 5 37 1.6094379124341 NA 4.06354528531854 4.00493418440079 0.0586111009177515 2.66787715581799 0.739482466535089 0.0534174652323506 0.0219691902942139 0.0792596221954782 0.911296880558456 NA NA NA 0.963318957114199 99.8785170793048 a10558 loss_cnaBRCA38 177 GSK-650394 SGK3 4 43 2.77258872223978 NA 3.92289142822009 4.02295484686272 -0.100063418642625 1.1541685824978 1.74171360087453 0.0585563276985467 0.0866974029271121 0.0574511323746812 0.911307057174799 NA NA NA 0.881822173599054 99.8785170793048 a10559 gain_cnaBRCA63 88 MS-275 HDAC 3 11 1.6094379124341 NA 1.24525852863444 1.11023973911526 0.135018789519183 2.63347623056209 1.62008377483596 0.0738448175239183 0.0512701758809363 0.0833406220199039 0.911608812273865 NA NA NA 0.939090096477913 99.8785170793048 a10560 gain_cnaBRCA58_(CCND1) 164 JQ12 HDAC 9 38 1.63315443905142 NA 1.63307652261323 1.56481106178783 0.0682654608253994 1.99891209142646 1.5694105343193 0.0412744923459646 0.0341513071626296 0.0434975166360842 0.911842956971763 NA NA NA 0.925563626062364 99.8785170793048 a10561 TP53_mut 1050 ZM-447439 AURKB 30 9 1.38629436111989 0.693147180559945 2.90089568011556 2.84468541970411 0.0562102604114498 1.22428674625861 1.65478520022884 0.0422876947821983 0.0459126594184139 0.0339683122641396 0.912006593469079 NA NA NA 0.926490911682205 99.8785170793048 a10562 loss_cnaBRCA17 197 Bryostatin 1 PRKC 11 37 -4.8283137373023 NA -2.835426906859 -2.79829438737563 -0.037132519483376 0.876612821124729 0.998896825687464 0.038138588172087 0.0423590878305128 0.0371735283649746 0.912055261669777 NA NA NA 0.906302234724572 99.8785170793048 a10563 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1264 SGC0946 Q8TEK3 (DOT1L) 8 38 -0.693147180559945 NA 1.97249224557994 1.94612869863504 0.0263635469448988 0.136392954555175 0.664396779763008 0.0431000063529734 0.193291119991348 0.0396804255347276 0.912279732301787 NA NA NA 0.824353447269327 99.8785170793048 a10564 gain_cnaBRCA10_(MDM2,NUP107) 1026 17-AAG HSP90 3 40 0 NA -0.785031872326892 -0.904544758568273 0.119512886241381 0.819939726607454 1.83760224906109 0.0663463463956031 0.145758136071626 0.0650374074707654 0.912288690971377 NA NA NA 0.840790906845741 99.8785170793048 a10565 gain_cnaBRCA10_(MDM2,NUP107) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 4 44 2.77258872223978 NA -0.361437303254868 -0.443353555927865 0.0819162526729972 1.9839515238295 1.37021353261773 0.0577542734457539 0.0412894426547678 0.0597835671032238 0.912421781294169 NA NA NA 0.940269383350079 99.8785170793048 a10566 gain_cnaBRCA13_(FGFR1,WHSC1L1) 41 S-Trityl-L-cysteine KIF11 3 9 1.63315443905142 NA 1.31954150166735 1.19234729625375 0.1271942054136 2.63482969583994 1.35836388341715 0.0751512629719574 0.0482741657323901 0.0936377998313867 0.912477908788927 NA NA NA 0.942405053481459 99.8785170793048 a10567 gain_cnaBRCA16 196 Phenformin AAPK1 (AMPK) agonist 16 32 8.29404964010203 NA 7.24306789783079 7.18148567716028 0.0615822206705099 2.38893314018519 1.47688372781269 0.0337422482809106 0.0257781264927892 0.04169740617409 0.912728791223546 NA NA NA 0.925627716136093 99.8785170793048 a10568 gain_cnaBRCA30_(CRNKL1,FOXA2) 1026 17-AAG HSP90 4 39 0 NA -0.801718600656866 -0.905897732232926 0.104179131576061 0.876654842528807 1.85482312889318 0.0578338650375963 0.118837114132108 0.0561666123056309 0.912822671514148 NA NA NA 0.85022790524053 99.8785170793048 a10569 loss_cnaBRCA20 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 3 46 1.63315443905142 NA 3.63851857064286 3.57262244129469 0.0658961293481712 1.23216747001342 0.9960906432904 0.0654208960708447 0.0534798482769989 0.0661547518712711 0.913044327270004 NA NA NA 0.935392995039726 99.8785170793048 a10570 loss_cnaBRCA29_(MAP2K4) 300 CX-5461 RNA Pol I 7 42 2.32630161961136 NA 3.84635939765679 3.92336627581821 -0.0770068781614239 2.27562259180153 1.62337382362296 0.044759371824142 0.0338399163546976 0.0474363187584015 0.913163565432223 NA NA NA 0.933886902637628 99.8785170793048 a10571 NF1_mut 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 5 40 -0.669430653942629 NA -3.37298551633842 -3.50034223695992 0.127356720621499 2.41323650926203 2.45421078851909 0.0519732527695876 0.0527742391318474 0.0518931467571082 0.913260768025424 NA NA NA 0.915823567861172 99.8785170793048 a10572 loss_cnaBRCA18 282 EKB-569 EGFR 15 32 0.916290731874155 2.99573227355399 1.62781193588577 1.55474972526773 0.0730622106180414 1.6116303135234 2.3291702646373 0.0342697559961361 0.0453343487057588 0.031368342506905 0.913279143032013 NA NA NA 0.901328843978403 99.8785170793048 a10573 loss_cnaBRCA17 1008 Methotrexate Dihydrofolate reductase (DHFR) 8 37 -1.6094379124341 NA 0.644178691640483 0.69096821127189 -0.046789519631407 1.0030880845065 1.1158572572393 0.0426022002188059 0.0466454744644151 0.0419314561319134 0.913502506726696 NA NA NA 0.908808833812659 99.8785170793048 a10574 MLL3_mut 1219 PFI-1 BRD2, BRD3, BRD4 3 44 2.30258509299405 NA 3.11127027538158 3.17665452519075 -0.0653842498091795 1.33935564023484 0.987259062370642 0.0650247130549438 0.0488176910187312 0.0662280573572821 0.91370887455734 NA NA NA 0.940915367042677 99.8785170793048 a10575 loss_cnaBRCA60 203 BMS-345541 IKBKB 3 46 2.77258872223978 NA 3.47045187789882 3.53636781505949 -0.0659159371606752 0.645818015571297 1.02891229975577 0.0649060895790208 0.102065807350334 0.0640637080306273 0.913725824199339 NA NA NA 0.881351804013676 99.8785170793048 a10576 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 257 NPK76-II-72-1 PLK3 9 40 2.32630161961136 NA 3.53123656765145 3.46719813618729 0.0640384314641591 1.36426363667798 1.63983370961618 0.0401170094892865 0.046939924031175 0.0390517837806542 0.913873136445081 NA NA NA 0.904405549008179 99.8785170793048 a10577 gain_cnaBRCA19 341 EX-527 SIRT1 4 45 2.99573227355399 NA 5.60743606270681 5.64480365444423 -0.037367591737417 0.975084180250081 0.632089734093901 0.0566745975021952 0.0383224264061317 0.0591175425289628 0.913962981080123 NA NA NA 0.944438120842103 99.8785170793048 a10578 gain_cnaBRCA62 1067 CCT007093 PPM1D 8 38 1.88706964903238 NA 4.12030971172534 4.07833654226014 0.0419731694652015 0.928145978658741 1.00518890101462 0.042254931509448 0.0452225947537441 0.0417564991245272 0.913992714487848 NA NA NA 0.910914516736824 99.8785170793048 a10579 loss_cnaBRCA18 5 Sunitinib PDGFRA, PDGFRB, KDR, KIT, FLT3 5 7 2.07944154167984 NA 3.3099817120683 3.21641947637381 0.0935622356944972 1.15967974994326 1.60391484350478 0.0648508488142863 0.0806793735072764 0.0583336678211985 0.914002817367876 NA NA NA 0.908968243709684 99.8785170793048 a10580 POLR2B_mut 290 KIN001-260 IKK 3 46 2.99573227355399 NA 4.98038717622897 5.04822709971479 -0.0678399234858249 0.704807761003567 1.06225199591648 0.0646387244131705 0.0962530880608189 0.0638642466633301 0.914079786046159 NA NA NA 0.887499480357889 99.8785170793048 a10581 loss_cnaBRCA29_(MAP2K4) 1199 Tamoxifen ER 7 40 1.6094379124341 NA 3.8328588370074 3.87552471471838 -0.042665877710979 0.760173205451393 0.987577980497372 0.0444263360822268 0.0561265214361822 0.0432025405117794 0.914132491544525 NA NA NA 0.898796177421408 99.8785170793048 a10582 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1039 SL 0101-1 RSK, AURKB, PIM3 8 35 2.30258509299405 NA 4.61520209824184 4.65651436165045 -0.0413122634086101 0.805054293625139 1.00333578899506 0.042487055279582 0.0513161208327726 0.0411749125883252 0.914192981406348 NA NA NA 0.902749111326259 99.8785170793048 a10583 BRCA2_mut 1003 Camptothecin TOP1 5 40 -2.30258509299405 NA -2.60237849124259 -2.52014431312775 -0.0822341781148457 1.75713318912802 1.58426820894351 0.0513598902880665 0.0468001962649483 0.0519067274408571 0.914280310728756 NA NA NA 0.924568626237807 99.8785170793048 a10584 TP53_mut 94 TGX221 PI3Kbeta 9 5 2.30258509299405 NA 3.74036046866843 3.82102276951048 -0.0806623008420559 1.44959270266771 0.996004077518238 0.061298885772479 0.0556448033255215 0.0809859142776239 0.914305785804221 NA NA NA 0.904487841096512 99.8785170793048 a10585 loss_cnaBRCA18 1026 17-AAG HSP90 12 31 0 NA -0.848447519476319 -0.914694055677282 0.0662465362009631 1.74345243125745 1.82213341138228 0.0367758196787242 0.0379973293295896 0.0363565783861612 0.914389900680299 NA NA NA 0.913185495408862 99.8785170793048 a10586 gain_cnaBRCA64_(SDHC) 238 CAL-101 PI3Kdelta 8 41 2.99573227355399 2.32630161961136 4.68568673575354 4.72545738697904 -0.0397706512255089 0.512264824072439 1.00985670798833 0.0417597009624528 0.0776368966921004 0.039382469721604 0.914421582095451 NA NA NA 0.870160416840319 99.8785170793048 a10587 loss_cnaBRCA36_(FAT1,IRF2) 1371 PLX4720 (rescreen) BRAF 9 38 2.30258509299405 NA 4.67595020284572 4.71453614031486 -0.0385859374691435 0.474740710874921 1.03960475858217 0.0400395955016978 0.0812779198944868 0.037115968497266 0.914469911433232 NA NA NA 0.868667139510652 99.8785170793048 a10588 gain_cnaBRCA19 151 QS11 ARFGAP 4 44 2.32630161961136 NA 3.83748876660945 3.75344635876888 0.0840424078405788 2.09582678323684 1.44028522786883 0.0563345642127515 0.0400998825441013 0.0583512253089865 0.914565994907776 NA NA NA 0.941977155006679 99.8785170793048 a10589 gain_cnaBRCA27_(CLTC,PPM1D) 1194 SB-505124 TGFR1 (ALK5) 10 37 2.30258509299405 NA 4.41695561110115 4.38144327252717 0.0355123385739793 0.953811223070718 0.91773991569905 0.0383889489380005 0.0372320410108514 0.0386954277203136 0.914704130187387 NA NA NA 0.917648252265307 99.8785170793048 a10590 loss_cnaBRCA28_(GPS2) 308 XL-880 MET 4 45 1.63315443905142 NA 1.93102841115671 1.8403248306991 0.0907035804576128 1.52450790534197 1.62210305818574 0.0561267275598018 0.059496956453805 0.0559172735664904 0.914791408947244 NA NA NA 0.915683764212891 99.8785170793048 a10591 gain_cnaBRCA63 9 MG-132 Proteasome 3 11 0 NA 0.237790703394954 0.354044189807283 -0.116253486412329 1.90165669957834 1.57641345682185 0.0710978523219116 0.0611327409611349 0.0737455557165211 0.914882502810857 NA NA NA 0.929123351722624 99.8785170793048 a10592 gain_cnaBRCA9_(KRAS) 1239 YK 4-279 RNA helicase A 4 38 2.30258509299405 NA 2.08032902991885 2.00652381175258 0.0738052181662727 0.813738640745284 1.33766078231587 0.0565262904539103 0.0906989228122144 0.0551748388993621 0.914902567068373 NA NA NA 0.879203090740122 99.8785170793048 a10593 gain_cnaBRCA61_(NOTCH2) 306 TG101348 JAK2 3 45 2.32630161961136 NA 3.14731583806592 3.23006047122987 -0.0827446331639523 0.291018639818137 1.32031359637495 0.0640083028168968 0.284327606010601 0.0626704393495122 0.914981964074299 NA NA NA 0.755512678509551 99.8785170793048 a10594 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 9 39 2.32630161961136 NA 4.98108139375564 4.95327709802831 0.0278042957273321 0.430251300386917 0.745629644943577 0.0396610413311078 0.0646233856872209 0.0372896865298805 0.915057106347034 NA NA NA 0.882990602090786 99.8785170793048 a10595 gain_cnaBRCA58_(CCND1) 1016 Temsirolimus MTOR 9 35 -1.6094379124341 NA -1.79913046735497 -1.73854937128223 -0.0605810960727391 1.59928719604872 1.4891099760114 0.0401009233345865 0.0378800607060531 0.040682754832525 0.915065109061416 NA NA NA 0.919874167101207 99.8785170793048 a10596 loss_cnaBRCA36_(FAT1,IRF2) 158 PF-562271 FAK 8 37 0.940007258491471 NA 2.28857028021014 2.34291072995234 -0.054340449742198 1.09952409972957 1.33453375820467 0.0418268406352598 0.0494217905324343 0.0407186775217298 0.915070534529838 NA NA NA 0.905133715742089 99.8785170793048 a10597 loss_cnaBRCA28_(GPS2) 328 SNX-2112 HSP90 4 44 0.940007258491471 NA 0.311839604330591 0.426821806980193 -0.114982202649602 1.54002497565623 2.08628622043193 0.055949924647117 0.0746625570800285 0.0551133404053243 0.915147034562361 NA NA NA 0.896612683743304 99.8785170793048 a10598 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 8 34 1.38629436111989 0.693147180559945 3.46931385478695 3.42498648051159 0.0443273742753627 0.486933645930221 1.13760080775867 0.0420897028645425 0.0910337058156687 0.0389656670187301 0.915236044100458 NA NA NA 0.865992241484973 99.8785170793048 a10599 gain_cnaBRCA12_(TERT) 235 QL-XII-47 BTK, BMX 9 40 2.32630161961136 NA 1.65924561365287 1.71906172808337 -0.0598161144304963 1.52811113098425 1.51248675651464 0.0394784769049504 0.0391438248290025 0.0395481905364486 0.915238618811546 NA NA NA 0.917131140658084 99.8785170793048 a10600 gain_cnaBRCA19 1194 SB-505124 TGFR1 (ALK5) 4 43 2.30258509299405 NA 4.43628862329963 4.38460006282136 0.0516885604782669 0.557932055080662 0.945855177618888 0.0558753860171024 0.0926431095105194 0.0546474362051794 0.915351612441764 NA NA NA 0.87598235526984 99.8785170793048 a10601 loss_cnaBRCA7_(FAS,PTEN) 167 OSU-03012 PDPK1 (PDK1) 4 44 2.77258872223978 NA 2.30900566261653 2.24243115167229 0.0665745109442417 0.534954197403159 1.22568929133415 0.0558091491225051 0.124448992581825 0.0543159766630384 0.915359702938709 NA NA NA 0.844057114474035 99.8785170793048 a10602 loss_cnaBRCA7_(FAS,PTEN) 261 TL-1-85 MAP3K7 (TAK1) 4 45 2.32630161961136 NA 3.96240531870352 4.03035323458619 -0.0679479158826726 1.10072868054053 1.22854814002364 0.0556590002486904 0.06172994043301 0.0553074915577711 0.915498729702964 NA NA NA 0.912828516062671 99.8785170793048 a10603 gain_cnaBRCA19 1036 PLX4720 BRAF 3 40 2.30258509299405 NA 4.66868593949299 4.59121040973803 0.0774755297549623 0.469764783200687 1.23849246562468 0.0639049612806511 0.16492409079091 0.0625563189969709 0.915503476729275 NA NA NA 0.826867521352034 99.8785170793048 a10604 loss_cnaBRCA36_(FAT1,IRF2) 1039 SL 0101-1 RSK, AURKB, PIM3 9 34 2.30258509299405 NA 4.61806305243535 4.65697211681712 -0.0389090643817722 0.670527233267547 1.03231843665215 0.0400153412978742 0.058027567638326 0.0376909517454285 0.915510833313573 NA NA NA 0.892867859871684 99.8785170793048 a10605 gain_cnaBRCA16 238 CAL-101 PI3Kdelta 16 33 2.99573227355399 2.32630161961136 4.73975112221455 4.70888572111322 0.0308654011013338 0.737596252918415 1.0378603032795 0.0324089500525258 0.0418459299097712 0.0297394562676725 0.915729010105397 NA NA NA 0.905425484251776 99.8785170793048 a10606 MLL3_mut 1038 NU-7441 PRKDC (DNAPK) 3 40 0.693147180559945 NA 2.94932772805526 2.88863031224423 0.0606974158110241 0.402876495370574 0.972560693375038 0.0637104402335473 0.150660106778365 0.0624099001990182 0.915759682024392 NA NA NA 0.838107495377137 99.8785170793048 a10607 NF1_mut 286 KIN001-236 TIE2 5 44 2.32630161961136 NA 4.57491202095659 4.53614853299453 0.038763487962064 0.501868419275678 0.79313186990669 0.0501708257373292 0.0772383486851183 0.0488739507676377 0.915790713156292 NA NA NA 0.883441223097958 99.8785170793048 a10608 loss_cnaBRCA34 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 3 23 2.30258509299405 NA 2.61907758756174 2.70099456329657 -0.0819169757348277 0.765990917060915 1.2843025250334 0.0655676762187678 0.106942489669644 0.0637832396480707 0.915824501112281 NA NA NA 0.882393283961593 99.8785170793048 a10609 gain_cnaBRCA27_(CLTC,PPM1D) 1020 Lenalidomide TNFA 10 35 1.6094379124341 NA 4.23353492042805 4.2607813358716 -0.0272464154435514 0.720068207289068 0.714874814073929 0.0380555173319983 0.0378386591266534 0.0381135478648066 0.915971395723364 NA NA NA 0.917274056256977 99.8785170793048 a10610 loss_cnaBRCA34 1036 PLX4720 BRAF 5 38 2.30258509299405 NA 4.54260955978847 4.60372174760679 -0.0611121878183178 0.966046604463409 1.23604975112237 0.0504077086536228 0.0632600824183453 0.0494415275459796 0.916131295415091 NA NA NA 0.90218133947607 99.8785170793048 a10611 gain_cnaBRCA12_(TERT) 1203 QL-XII-61 BTK 5 18 2.30258509299405 NA 4.28985271116425 4.20725501776565 0.082597693398605 1.58015310288881 1.52370229885085 0.0538230740344405 0.0522719559564204 0.0542085507522688 0.916220279280017 NA NA NA 0.920282581151336 99.8785170793048 a10612 gain_cnaBRCA47_(EGFR) 287 KIN001-244 PDPK1 (PDK1) 7 42 2.99573227355399 NA 3.44297323292083 3.48396151001325 -0.040988277092421 0.835674426742168 0.965207559466938 0.0431611964185501 0.0490481409754414 0.0424657646849118 0.916252145487448 NA NA NA 0.909168899585267 99.8785170793048 a10613 loss_cnaBRCA34 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 5 42 2.77258872223978 NA 5.05697169422564 5.00541693395133 0.0515547602743052 0.678699662422677 1.06081469281098 0.0499275783885959 0.0759610813570704 0.0485992140038084 0.91641943203088 NA NA NA 0.885617349249036 99.8785170793048 a10614 MACF1_mut 1378 Bleomycin (50 uM) DNA damage 3 45 3.91202300542815 NA 3.92474871130162 3.80524887329524 0.119499838006377 1.57093698816885 1.91370098744432 0.0628918583814075 0.076069147843842 0.0624443624110602 0.916459205209817 NA NA NA 0.909689330794422 99.8785170793048 a10615 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1033 Vismodegib SMO 8 37 2.30258509299405 NA 4.73310595341739 4.76554075698231 -0.0324348035649242 0.817848796461173 0.78282816467989 0.0411277665162689 0.0396586798259892 0.0414328520974808 0.916484582003619 NA NA NA 0.920407492693872 99.8785170793048 a10616 CDH1_mut 176 IPA-3 PAK1, PAK2, PAK3 4 43 3.46573590279973 NA 4.42017576209368 4.50397095585575 -0.0837951937620751 0.428146642226161 1.57017477356268 0.0550937772127179 0.195716106347067 0.0533667940492678 0.916531204244646 NA NA NA 0.798065866311795 99.8785170793048 a10617 loss_cnaBRCA18 1194 SB-505124 TGFR1 (ALK5) 15 32 2.30258509299405 NA 4.36827962118434 4.3987113398985 -0.0304317187141594 1.06999168227438 0.851579137003164 0.0328965822124829 0.0284410797002398 0.0357356320649813 0.916740671777842 NA NA NA 0.92379615712561 99.8785170793048 a10618 gain_cnaBRCA19 1248 FK866 NAMPT 4 40 0 NA -0.787767846127093 -0.636999672790011 -0.150768173337082 1.99250138047939 2.78508430651694 0.0551033949047328 0.0756677886470561 0.0541341506195317 0.916814107964097 NA NA NA 0.89619014335842 99.8785170793048 a10619 ARID1A_mut 292 Masitinib KIT 5 43 2.99573227355399 NA 4.05912132822132 4.00465366664261 0.0544676615787107 0.878253387516074 1.11630369208889 0.0496218397020686 0.062018162813763 0.0487928705823661 0.916816647006515 NA NA NA 0.903176402920342 99.8785170793048 a10620 gain_cnaBRCA47_(EGFR) 298 OSI-930 KIT, VEGFR, PDGFR 7 41 2.32630161961136 NA 3.9456360343232 3.90785799973084 0.037778034592356 0.844958645263494 0.885588167579513 0.0429103236403139 0.0447099213720396 0.0426586939340109 0.916890909817852 NA NA NA 0.916103147446083 99.8785170793048 a10621 gain_cnaBRCA13_(FGFR1,WHSC1L1) 275 I-BET BRD2, BRD3, BRD4 11 38 2.99573227355399 NA 4.07707633357044 4.02790190099954 0.049174432570906 1.32360043954788 1.38128253844129 0.0359143702380803 0.0371520219407778 0.0356005604953182 0.916904825971384 NA NA NA 0.915707550590886 99.8785170793048 a10622 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1502 Bicalutamide ANDR (androgen receptor) 6 39 2.30258509299405 NA 4.58175411815964 4.55469528907038 0.0270588290892571 0.429636995823635 0.605941411814728 0.0460057040516491 0.0629806775307698 0.0446558504859716 0.91693574269342 NA NA NA 0.895787899086359 99.8785170793048 a10623 gain_cnaBRCA9_(KRAS) 1036 PLX4720 BRAF 4 39 2.30258509299405 NA 4.53604222848061 4.60282834087379 -0.0667861123931788 0.321458081475098 1.25606529646307 0.0550876358567186 0.207759942094821 0.0531708921353374 0.916946345433148 NA NA NA 0.798526127759225 99.8785170793048 a10624 ARID1A_mut 1031 Elesclomol HSP70 5 39 -1.6094379124341 NA -3.05697547229087 -2.96740004470919 -0.0895754275816754 2.6194182669889 1.69064065606367 0.0497678734855662 0.0341966873754168 0.0529831264026471 0.917056474459055 NA NA NA 0.943850367361134 99.8785170793048 a10625 gain_cnaBRCA13_(FGFR1,WHSC1L1) 260 NG-25 MAP3K7 (TAK1) 11 38 2.32630161961136 NA 3.24433361988427 3.19792518448326 0.0464084354010126 1.46439469531332 1.24475666404376 0.0358473527194531 0.0316912069878013 0.0372831387383366 0.917059306341121 NA NA NA 0.925162325228277 99.8785170793048 a10626 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1375 Temozolomide DNA akylating agent 6 40 3.40119738166216 NA 5.92813967105296 5.89592387507108 0.0322157959818865 0.55448180980781 0.720378345014487 0.0457936346844149 0.0581007265018358 0.0447206613092161 0.917168556629874 NA NA NA 0.902057971714641 99.8785170793048 a10627 loss_cnaBRCA20 184 BMS-754807 IGF1R 3 45 0.940007258491471 NA 1.52843359184498 1.6334313122022 -0.104997720357221 1.0211262722718 1.7153803143973 0.0620872320195293 0.102825402899117 0.0612095868630229 0.917524044418772 NA NA NA 0.881215023047344 99.8785170793048 a10628 loss_cnaBRCA36_(FAT1,IRF2) 1203 QL-XII-61 BTK 3 20 2.30258509299405 NA 4.13904081187548 4.23813657199883 -0.0990957601233458 1.07946521068438 1.5749100527248 0.0645729927135675 0.0918007909310199 0.0629215363454548 0.917925094908027 NA NA NA 0.897605949941069 99.8785170793048 a10629 loss_cnaBRCA7_(FAS,PTEN) 265 Tubastatin A HDAC6 4 45 2.99573227355399 NA 4.74350526815524 4.68715986888675 0.0563453992684888 1.02014358249797 1.04412098930054 0.0540427982028839 0.0552328125522474 0.0539644350088535 0.917943359752342 NA NA NA 0.921501826409087 99.8785170793048 a10630 loss_cnaBRCA7_(FAS,PTEN) 1219 PFI-1 BRD2, BRD3, BRD4 4 43 2.30258509299405 NA 3.2222006041674 3.16785598878764 0.0543446153797658 0.620944146773269 1.0275200205039 0.0540450717532175 0.0875193294955224 0.0528891060955826 0.918114192139973 NA NA NA 0.882311184090313 99.8785170793048 a10631 loss_cnaBRCA23 290 KIN001-260 IKK 3 46 2.99573227355399 NA 5.1047539661281 5.04011622211268 0.064637744015422 0.782604368490937 1.0598409956887 0.0615869372816817 0.0825931295784359 0.0609881522590279 0.91812124259629 NA NA NA 0.902562722453328 99.8785170793048 a10632 loss_cnaBRCA29_(MAP2K4) 208 SB-715992 KIF11 7 42 -2.05572501506252 NA -1.1777633720321 -1.25025526882286 0.0724918967907564 1.33564363161867 1.76985456675192 0.0421333244039075 0.0542748792227634 0.0409592393367074 0.918239269184784 NA NA NA 0.902021220057436 99.8785170793048 a10633 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 223 ZSTK474 PI3K 6 43 1.63315443905142 2.32630161961136 0.854795896144009 0.920367086707674 -0.0655711905636656 1.13508840263989 1.49207984795179 0.0449653004192797 0.057767474684056 0.0439461672602015 0.918260282923076 NA NA NA 0.902203913123822 99.8785170793048 a10634 loss_cnaBRCA20 1264 SGC0946 Q8TEK3 (DOT1L) 3 43 -0.693147180559945 NA 1.91553930226253 1.95316768851125 -0.0376283862487179 0.155530594307505 0.625168898176989 0.0615149783484104 0.241935590976535 0.0601891526568954 0.918419838967845 NA NA NA 0.780728028095015 99.8785170793048 a10635 NF1_mut 295 NVP-BHG712 EPHB4 5 44 2.32630161961136 NA 3.83271400669395 3.89284396203639 -0.0601299553424468 0.905308292823773 1.26445772458858 0.0485720059371145 0.0664193135300835 0.0475539467814249 0.918464433732477 NA NA NA 0.897545548362926 99.8785170793048 a10636 loss_cnaBRCA7_(FAS,PTEN) 1371 PLX4720 (rescreen) BRAF 4 43 2.30258509299405 NA 4.75458699113763 4.70273435332618 0.0518526378114537 0.504305119575227 0.988383016116867 0.0538054555291579 0.102819971082445 0.052462089054475 0.918475932622168 NA NA NA 0.866237800085971 99.8785170793048 a10637 gain_cnaBRCA27_(CLTC,PPM1D) 253 XMD14-99 EPHB3, CAMK1 9 39 2.32630161961136 NA 4.95706745437308 4.92757131388064 0.0294961404924416 0.777007046316087 0.779270483859409 0.03787007263253 0.0379612265194859 0.0378509658756216 0.918878859607222 NA NA NA 0.919975975779402 99.8785170793048 a10638 loss_cnaBRCA22_(SYNCRIP,ZNF292) 329 QL-XI-92 DDR1 18 30 2.32630161961136 NA 4.27153421633582 4.24241562730676 0.0291185890290668 1.15815958668016 0.810264325928053 0.0305311433341259 0.0251421214864997 0.0359371480358774 0.918880673957794 NA NA NA 0.925971712285139 99.8785170793048 a10639 loss_cnaBRCA38 1261 rTRAIL TR10A (DR4), TR10B (DR5) 3 44 -2.30258509299405 NA -0.200287659909334 -0.136536598156156 -0.0637510617531773 0.153974002403135 1.06860493581284 0.061000400631841 0.414037829491918 0.0596582138231327 0.919029729293906 NA NA NA 0.73194930289231 99.8785170793048 a10640 loss_cnaBRCA34 286 KIN001-236 TIE2 5 44 2.32630161961136 NA 4.57352586307738 4.53630605093535 0.037219812142026 0.422107651898797 0.797449652822103 0.0481724241673202 0.0881761133080564 0.046673557396769 0.919132807790809 NA NA NA 0.872154763600945 99.8785170793048 a10641 loss_cnaBRCA34 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 5 43 2.07944154167984 NA 3.2648091542397 3.20843069460424 0.0563784596354564 0.777482819712917 1.20043919492386 0.0481971293912884 0.072514090608811 0.0469648607558438 0.919196378591022 NA NA NA 0.890275155695775 99.8785170793048 a10642 loss_cnaBRCA23 133 Doxorubicin DNA intercalating 3 45 0.0237165266173161 NA -1.13605466432228 -1.02361767148139 -0.112436992840889 0.764008089522888 1.88336583169229 0.0608147445855311 0.147167280533776 0.0597000279759028 0.919208360253801 NA NA NA 0.84046175718495 99.8785170793048 a10643 MACF1_mut 1377 Afatinib (rescreen) ERBB2, EGFR 3 44 2.30258509299405 NA 2.72069659885829 2.84240900712618 -0.121712408267887 1.07526088036101 2.03618847774807 0.0607561900985571 0.11319337519935 0.0597746277409915 0.919352742094899 NA NA NA 0.871386611609387 99.8785170793048 a10644 gain_cnaBRCA14_(RAD21) 71 Pyrimethamine Dihydrofolate reductase (DHFR) 6 8 2.99573227355399 NA 4.5366053902827 4.59426968180282 -0.0576642915201164 0.991888188417964 1.06208176952262 0.0557997954824125 0.0581358788152216 0.054293645908295 0.919414736651037 NA NA NA 0.918665300645141 99.8785170793048 a10645 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 193 GW-2580 CSF1R (cFMS) 7 41 2.99573227355399 NA 5.49005499430449 5.45883611417578 0.0312188801287094 1.07083758015058 0.690789719993796 0.0415507489166927 0.0291537023983781 0.0451930294055184 0.919514751213525 NA NA NA 0.942709083792507 99.8785170793048 a10646 loss_cnaBRCA7_(FAS,PTEN) 150 Bicalutamide ANDR (androgen receptor) 4 44 0.0237165266173161 NA 2.79305221361285 2.75981824616542 0.0332339674474298 0.360042724644432 0.642656949255695 0.0529107499061266 0.092305621451595 0.0517133868791434 0.919739657942929 NA NA NA 0.877276392217511 99.8785170793048 a10647 loss_cnaBRCA33 282 EKB-569 EGFR 6 41 0.916290731874155 2.99573227355399 1.6604288739427 1.5660145610536 0.0944143128891017 1.50723607579697 2.19765810934274 0.0442840871023813 0.0626406933891754 0.0429613289199649 0.919751865379349 NA NA NA 0.896522552502158 99.8785170793048 a10648 loss_cnaBRCA34 283 GSK2126458 PI3K, MTOR 5 43 -2.05572501506252 0.0237165266173161 -2.98488546440206 -3.06355237372859 0.0786669093265293 0.746360328122309 1.70740857846918 0.047785121793334 0.105400711107515 0.0460738632325838 0.919884706217767 NA NA NA 0.856295009707129 99.8785170793048 a10649 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 41 S-Trityl-L-cysteine KIF11 3 9 1.63315443905142 NA 1.31144146566779 1.19504730825361 0.116394157414175 1.53576496986618 1.72969093006976 0.0687630722709538 0.0757890430488964 0.0672918816828625 0.919887372325867 NA NA NA 0.917831480529514 99.8785170793048 a10650 gain_cnaBRCA27_(CLTC,PPM1D) 41 S-Trityl-L-cysteine KIF11 3 9 1.63315443905142 NA 1.31144146566779 1.19504730825361 0.116394157414175 1.53576496986618 1.72969093006976 0.0687630722709538 0.0757890430488964 0.0672918816828625 0.919887372325867 NA NA NA 0.917831480529514 99.8785170793048 a10651 gain_cnaBRCA14_(RAD21) 279 BIX02189 MAP2K5 (MEK5) 21 28 2.99573227355399 NA 5.0122464712519 5.03868822451525 -0.0264417532633434 1.06643835958512 0.766994746014145 0.0291662229338665 0.0247944506362563 0.0344744907325034 0.919952652791629 NA NA NA 0.923723019748401 99.8785170793048 a10652 gain_cnaBRCA64_(SDHC) 291 KIN001-266 MAP3K8 (COT) 8 41 2.99573227355399 NA 3.73984426012083 3.78620321849172 -0.0463589583708903 1.6821974822716 1.07916930532116 0.0390051713833145 0.0275585707739191 0.0429580031069306 0.920046225910445 NA NA NA 0.942025141591973 99.8785170793048 a10653 loss_cnaBRCA22_(SYNCRIP,ZNF292) 153 Midostaurin KIT 17 30 -0.669430653942629 NA 0.583654228164708 0.628350971834997 -0.0446967436702885 1.46959215891294 1.46505920436876 0.0304749307425389 0.0304143863310695 0.0305084897163229 0.920482757863253 NA NA NA 0.920708326286472 99.8785170793048 a10654 gain_cnaBRCA8_(CHD4,WNK1) 277 ABT-869 VEGFR and PDGFR family 4 44 0.0237165266173161 NA 2.66809734840732 2.69316742060811 -0.0250700722007817 0.565908531986955 0.472330727026024 0.0523393149748879 0.0443005729437556 0.0530773688145011 0.920603490828459 NA NA NA 0.93635542269579 99.8785170793048 a10655 loss_cnaBRCA7_(FAS,PTEN) 1043 JNK Inhibitor VIII JNK 4 39 2.30258509299405 NA 4.83323828304103 4.79364840149804 0.0395898815429838 0.351582573140568 0.775091683616901 0.0526298718195709 0.112604789223029 0.0510776755573494 0.920638836147294 NA NA NA 0.859550649796549 99.8785170793048 a10656 NF1_mut 262 VX-11e ERK 5 44 1.63315443905142 NA 3.83368552004201 3.7703490383036 0.0633364817384052 0.890624150436786 1.37475586970732 0.0472526918422504 0.0711147139984283 0.046071075697163 0.92067145271786 NA NA NA 0.892146141828643 99.8785170793048 a10657 gain_cnaBRCA10_(MDM2,NUP107) 1495 AZD-2281 PARP1, PARP2 3 42 2.30258509299405 NA 3.93509888440049 4.00323361213781 -0.0681347277373145 1.61504377668769 1.110484405317 0.0598239985953583 0.0421875423569341 0.0613558618302835 0.920726483350683 NA NA NA 0.948872301014936 99.8785170793048 a10658 gain_cnaBRCA12_(TERT) 1170 CCT018159 HSP90 10 33 2.30258509299405 NA 3.37611350225951 3.33274201874067 0.043371483518837 0.729353231215318 1.30353032012889 0.036105701339691 0.0594656767977394 0.0332723242789999 0.920813807688756 NA NA NA 0.894338025259442 99.8785170793048 a10659 ARID1A_mut 300 CX-5461 RNA Pol I 5 44 2.32630161961136 NA 3.98511829526226 3.90409790662844 0.0810203886338203 1.85320230816589 1.70763311848111 0.0470911453812662 0.0437191278452517 0.0474460162179835 0.920941739956001 NA NA NA 0.929385590979597 99.8785170793048 a10660 PIK3CA_mut 1373 Dabrafenib BRAF 16 30 2.30258509299405 NA 4.24772572011056 4.1969162842947 0.0508094358158635 1.33954060248351 1.7866080169252 0.0308331825553454 0.0379304932763239 0.0284390506112851 0.921114182962539 NA NA NA 0.914011043106626 99.8785170793048 a10661 gain_cnaBRCA16 34 Imatinib ABL, KIT, PDGFR 3 11 0.693147180559945 NA 2.75222044786157 2.78426865755423 -0.0320482096926633 0.105557143541243 0.531822346938096 0.0657542172595378 0.30361005060867 0.0602611189190847 0.921255387212777 NA NA NA 0.854955361356554 99.8785170793048 a10662 loss_cnaBRCA34 293 MP470 PDGFR 5 43 2.99573227355399 NA 3.46081791723314 3.53981392642933 -0.0789960091961914 1.49427327621679 1.69890915388697 0.0469626388414681 0.0528658381659571 0.0464980773194699 0.92125898652624 NA NA NA 0.916303049687652 99.8785170793048 a10663 PTEN_mut 178 BAY 61-3606 SYK 8 40 2.07944154167984 NA 3.04390115244992 3.10612315550244 -0.0622220030525225 1.51016927175428 1.63724237728541 0.0384430796627832 0.0412020057726659 0.0380041488760438 0.92136346292861 NA NA NA 0.918448326268088 99.8785170793048 a10664 TP53_mut 1268 XAV 939 TNKS1 (tankyrase-1) 37 10 1.6094379124341 NA 3.66856408950179 3.63509349195124 0.0334705975505476 0.817093128794409 1.34470214152246 0.0353645541557497 0.0409630143383194 0.0248907148408735 0.921400517284278 NA NA NA 0.941535433938021 99.8785170793048 a10665 gain_cnaBRCA8_(CHD4,WNK1) 341 EX-527 SIRT1 4 45 2.99573227355399 NA 5.67308742407076 5.63896797787854 0.0341194461922161 0.871476176763707 0.642340452105586 0.0517471270647609 0.0391513240429833 0.0531173867072716 0.921417110347163 NA NA NA 0.943448284138451 99.8785170793048 a10666 gain_cnaBRCA9_(KRAS) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 38 -1.38629436111989 0.693147180559945 -0.382637960693027 -0.293774717036299 -0.0888632436567273 1.24252859129975 1.74284416100695 0.0519545186127366 0.0715180674947459 0.0509874868016802 0.921761187885053 NA NA NA 0.902210550904008 99.8785170793048 a10667 gain_cnaBRCA14_(RAD21) 1066 AZD6482 PI3Kbeta 19 24 1.6094379124341 NA 1.94262408834836 1.98663378143755 -0.0440096930891953 1.63188118278914 1.29091569433505 0.0303408130076754 0.0269686871528084 0.0340918413823023 0.921775233218268 NA NA NA 0.923985926585761 99.8785170793048 a10668 loss_cnaBRCA34 1378 Bleomycin (50 uM) DNA damage 5 43 3.91202300542815 NA 3.8921288009947 3.80348375412133 0.0886450468733679 1.53792669168415 1.93106707923188 0.0466525183216122 0.0576393188002315 0.0459046958164853 0.921777227756714 NA NA NA 0.909832612214411 99.8785170793048 a10669 loss_cnaBRCA29_(MAP2K4) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 7 41 2.32630161961136 NA 4.93431521234923 4.96261787513317 -0.028302662783946 0.787105519384632 0.687226272873557 0.0403711588561019 0.0359579015607378 0.041183906816603 0.921791975108852 NA NA NA 0.930992504984963 99.8785170793048 a10670 gain_cnaBRCA9_(KRAS) 204 Tipifarnib Farnesyl-transferase (FNTA) 4 44 2.77258872223978 NA 1.6919559813324 1.61343294078941 0.0785230405429957 1.74544772483455 1.50883109085123 0.0514776293945152 0.0449873344390414 0.0520423001746974 0.921906275586097 NA NA NA 0.935471565263434 99.8785170793048 a10671 gain_cnaBRCA8_(CHD4,WNK1) 312 AV-951 VEGFR 4 44 -2.05572501506252 NA 0.601773935291648 0.635048749610051 -0.0332748143184024 0.571992011476923 0.651302794823534 0.0514749734063705 0.0581735647539632 0.051089623110581 0.921910291518234 NA NA NA 0.91801728091195 99.8785170793048 a10672 gain_cnaBRCA9_(KRAS) 150 Bicalutamide ANDR (androgen receptor) 4 44 0.0237165266173161 NA 2.79213661836301 2.75990148209722 0.0322351362657889 0.525176798648972 0.63467703001326 0.051320203311298 0.0613795894043957 0.050789826543928 0.92214431199887 NA NA NA 0.913946297964492 99.8785170793048 a10673 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 211 TL-2-105 CRAF 6 43 2.32630161961136 1.63315443905142 3.94872582370284 3.90180879412203 0.0469170295808139 0.991472221543634 1.10809545861271 0.0427966297349018 0.0473205689088982 0.0423402417329207 0.922189327624148 NA NA NA 0.917874002378866 99.8785170793048 a10674 loss_cnaBRCA28_(GPS2) 1019 Bosutinib SRC, ABL, TEC 3 42 0.693147180559945 NA 2.71409684456089 2.65892008679206 0.0551767577688271 0.790847450677193 0.9483094579678 0.0586008191623663 0.0697691542428062 0.0581843377235416 0.92234196989742 NA NA NA 0.917206519787196 99.8785170793048 a10675 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 7 38 0.693147180559945 NA 0.576367472994814 0.634632347237975 -0.0582648742431613 0.915871593013192 1.51592392554886 0.0402601511802387 0.0636168592711468 0.0384352230749744 0.92247957299501 NA NA NA 0.8929559563108 99.8785170793048 a10676 gain_cnaBRCA13_(FGFR1,WHSC1L1) 205 BMS-708163 g-secretase 11 37 2.32630161961136 0.940007258491471 4.87882352471947 4.9017934614548 -0.0229699367353309 0.681949562317899 0.684696161489386 0.0335768693270519 0.03368275016888 0.0335476347426361 0.922537722342117 NA NA NA 0.92312191896373 99.8785170793048 a10677 loss_cnaBRCA38 1371 PLX4720 (rescreen) BRAF 3 44 2.30258509299405 NA 4.65454587998736 4.71073380721851 -0.0561879272311492 0.202757016722768 0.984904249413 0.0583033373707146 0.277119520396059 0.0570491266177773 0.922597839314077 NA NA NA 0.771355727415155 99.8785170793048 a10678 loss_cnaBRCA36_(FAT1,IRF2) 269 NSC-207895 MDM4 9 40 2.99573227355399 NA 4.63914479683391 4.59602186009373 0.0431229367401844 1.1972633505391 1.1965108399794 0.0360367146405645 0.0360179209701585 0.0360405733899803 0.922603065136652 NA NA NA 0.923847640468159 99.8785170793048 a10679 gain_cnaBRCA47_(EGFR) 221 TAK-715 p38a 7 42 2.99573227355399 2.32630161961136 4.51669065926926 4.47639638966668 0.0402942696025823 0.939223991155509 1.02449557243856 0.0397375780829628 0.0429016613523778 0.0393308382062323 0.92287284756806 NA NA NA 0.919801635182068 99.8785170793048 a10680 gain_cnaBRCA16 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 16 32 2.32630161961136 NA 4.97241671385475 4.95152724828839 0.0208894655663556 0.931788112145394 0.556054860748633 0.0297968223840781 0.0224186864954294 0.0375672744560339 0.922898226622114 NA NA NA 0.934954861238499 99.8785170793048 a10681 gain_cnaBRCA19 312 AV-951 VEGFR 4 44 -2.05572501506252 NA 0.662367045838504 0.629540285014882 0.0328267608236219 0.756650197701767 0.638028829045135 0.0507817068806376 0.0433843286148992 0.0514502783091322 0.922958600894342 NA NA NA 0.937695060523897 99.8785170793048 a10682 gain_cnaBRCA14_(RAD21) 175 PAC-1 CASP3 agonist 21 27 0.940007258491471 NA 2.42093275670395 2.38617550130912 0.0347572553948328 1.13061017404686 1.30430333138969 0.0282166917426299 0.0307420331009619 0.0266481381733496 0.923164504613246 NA NA NA 0.921769433422991 99.8785170793048 a10683 BRCA1_mut 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 41 2.30258509299405 NA 3.23741734291104 3.17095962556565 0.0664577173453904 0.917132606788469 1.33768361200385 0.0506258830531871 0.0724624954488381 0.0496811927342346 0.923455804255363 NA NA NA 0.900940996138752 99.8785170793048 a10684 POLR2B_mut 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 3 40 1.6094379124341 NA 2.94539962569513 2.86215090476735 0.0832487209277861 2.36894988628198 1.37468802532476 0.0578432007756741 0.0351416133409404 0.0605582644164802 0.923491611772788 NA NA NA 0.957295283880555 99.8785170793048 a10685 loss_cnaBRCA57 172 Embelin XIAP 5 43 3.46573590279973 NA 3.03288989061814 2.98843105063131 0.0444588399868318 0.61963193981719 1.00234414064606 0.0455966395866968 0.0717504007297437 0.0443548659427248 0.92354195862845 NA NA NA 0.892380981429796 99.8785170793048 a10686 loss_cnaBRCA36_(FAT1,IRF2) 1264 SGC0946 Q8TEK3 (DOT1L) 9 37 -0.693147180559945 NA 1.96832337201756 1.94643022066522 0.0218931513523422 0.370110742386929 0.653370387258563 0.0357904332261526 0.0591529746236172 0.0335080251252315 0.923722426657152 NA NA NA 0.894750794846848 99.8785170793048 a10687 ARID1A_mut 312 AV-951 VEGFR 5 43 -2.05572501506252 NA 0.60597938581221 0.635333576626692 -0.0293541908144828 0.5399118240141 0.655673134871063 0.0454096695311229 0.054368490388379 0.0447695494192471 0.923854489670196 NA NA NA 0.914572439002326 99.8785170793048 a10688 gain_cnaBRCA31 152 CP466722 ATM 16 33 2.77258872223978 NA 2.7090688052038 2.74035895120981 -0.0312901460060191 0.797862016952784 1.17489824324899 0.0292673936721065 0.0392174904196132 0.026632217884241 0.923870796342997 NA NA NA 0.913311880419377 99.8785170793048 a10689 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 294 MPS-1-IN-1 MPS1 6 43 2.99573227355399 NA 4.71329624829235 4.76254860360468 -0.0492523553123236 1.13015019983003 1.18686842636765 0.0417052110257366 0.0435803624330033 0.041497738264938 0.924167431067818 NA NA NA 0.92377316873798 99.8785170793048 a10690 gain_cnaBRCA16 1019 Bosutinib SRC, ABL, TEC 15 30 0.693147180559945 NA 2.64359469479841 2.67210045856577 -0.0285057637673556 1.04405144868363 0.887879964114843 0.0302745655772247 0.0273030259220428 0.0321054251919897 0.924174573858454 NA NA NA 0.928532820901635 99.8785170793048 a10691 loss_cnaBRCA23 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 44 2.99573227355399 NA 3.77096916289848 3.85289144146787 -0.0819222785693912 2.07993894910424 1.40155408800849 0.056949241409602 0.0393868669100467 0.0584510289473001 0.924389867721716 NA NA NA 0.952221922003464 99.8785170793048 a10692 loss_cnaBRCA17 155 AP-24534 ABL 10 37 -0.669430653942629 NA 1.41476828562892 1.45362772720725 -0.0388594415783265 1.18378268586412 1.13311282685628 0.0339850821117815 0.0328264993586729 0.0342944150461507 0.924456784113948 NA NA NA 0.92729070758729 99.8785170793048 a10693 gain_cnaBRCA27_(CLTC,PPM1D) 158 PF-562271 FAK 8 37 0.940007258491471 NA 2.29353452337753 2.34183738007831 -0.0483028567007864 1.63620033397311 1.22295158696278 0.0371785504973733 0.02952135853896 0.0394969491971039 0.924477836867976 NA NA NA 0.938905544691191 99.8785170793048 a10694 loss_cnaBRCA33 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 5 9 1.38629436111989 NA 1.94929147321021 1.90463488315827 0.0446565900519411 0.614314378461092 0.915113016077837 0.0539922585765013 0.072693382440127 0.0487989890509248 0.924483423367139 NA NA NA 0.915278505215856 99.8785170793048 a10695 POLR2B_mut 1050 ZM-447439 AURKB 3 36 1.38629436111989 0.693147180559945 2.95804761551467 2.88208045372944 0.0759671617852273 2.13032258879553 1.26833208508333 0.05714848766093 0.0356599334695965 0.0598953244806041 0.924747930791718 NA NA NA 0.956717431871324 99.8785170793048 a10696 loss_cnaBRCA28_(GPS2) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 4 42 1.63315443905142 NA 1.86381270637212 1.94352661834164 -0.0797139119695196 2.25425983231898 1.54642898816709 0.0496771422390005 0.0353614569299746 0.0515470885371858 0.92479646258453 NA NA NA 0.94885078039963 99.8785170793048 a10697 gain_cnaBRCA48 1133 JNJ-26854165 MDM2 5 38 2.30258509299405 NA 2.93369493566588 2.97343694468733 -0.0397420090214511 0.631561785208511 0.902410777870393 0.0451785561747661 0.062926557547066 0.0440398208842747 0.924803290551557 NA NA NA 0.90442210640272 99.8785170793048 a10698 gain_cnaBRCA13_(FGFR1,WHSC1L1) 53 CGP-60474 CDK1,CDK2,CDK5,CDK7,CDK9 3 9 -1.36257783450257 NA -1.77564512270478 -1.6750745818057 -0.100570540899081 2.63444289583081 1.14083913895511 0.0645257378525838 0.0381752593909857 0.0881548830724663 0.924806611722873 NA NA NA 0.954093279628284 99.8785170793048 a10699 PIK3CA_mut 88 MS-275 HDAC 4 10 1.6094379124341 NA 1.21359901134948 1.10940166707733 0.104197344272151 1.75188296051597 1.85357844323397 0.0569793885379765 0.0594773433046364 0.0562141541149756 0.924861991221975 NA NA NA 0.924524106781226 99.8785170793048 a10700 gain_cnaBRCA58_(CCND1) 276 CAY10603 HDAC6 10 39 2.99573227355399 NA 1.20223645673095 1.16869443479339 0.033542021937552 1.09348081666108 0.975358076139963 0.0335736135051074 0.0306745408117645 0.0343894439981432 0.924941521476993 NA NA NA 0.930912527264943 99.8785170793048 a10701 loss_cnaBRCA34 345 KIN001-270 CDK9 5 44 2.99573227355399 NA 5.13548029027193 5.10441729475674 0.031062995515196 0.188829677929538 0.724701738453167 0.0446716128857784 0.164502719359545 0.0428631447490358 0.924991027518937 NA NA NA 0.824028178168636 99.8785170793048 a10702 gain_cnaBRCA10_(MDM2,NUP107) 272 AR-42 HDAC 5 44 1.63315443905142 NA 0.203688042463008 0.134955049609013 0.068732992853995 0.922125411430965 1.58661797918568 0.0445953417961421 0.0745375759109971 0.0433204424478233 0.925118706684694 NA NA NA 0.889386539796295 99.8785170793048 a10703 gain_cnaBRCA30_(CRNKL1,FOXA2) 1069 EHT 1864 Rac GTPases 5 41 2.30258509299405 NA 3.5959546428947 3.55721035735146 0.0387442855432387 1.06302980364587 0.843189931963443 0.0447659330908157 0.0364470360194584 0.0459496538970991 0.925138648363114 NA NA NA 0.940674912018552 99.8785170793048 a10704 gain_cnaBRCA27_(CLTC,PPM1D) 9 MG-132 Proteasome 3 11 0 NA 0.409414009229359 0.307237833670627 0.102176175558732 2.39070836435381 1.43734704548651 0.0624814484164014 0.0427388706553297 0.0710866424915133 0.925161382857461 NA NA NA 0.949133220251261 99.8785170793048 a10705 TP53_mut 91 KIN001-135 IKKE 9 5 1.6094379124341 NA 3.71139479150969 3.68911678384715 0.0222780076625408 0.481521617093564 0.239129049679548 0.0534633432752157 0.0462658515665602 0.0931631171218852 0.925220731657958 NA NA NA 0.909958966908038 99.8785170793048 a10706 BRCA2_mut 281 CH5424802 ALK 6 42 1.63315443905142 NA 3.53658152928651 3.58076221129886 -0.0441806820123447 1.09322028588852 1.07045571122502 0.0411766970983247 0.0404133389973062 0.041272779012767 0.925242764961697 NA NA NA 0.928849913501 99.8785170793048 a10707 ARID1A_mut 140 Vinorelbine Microtubules 5 42 -2.74887219562247 NA -3.66595353671441 -3.59194373227814 -0.0740098044362658 1.80568680228612 1.64383590864992 0.0446147986529196 0.0409870661637247 0.0450226230287486 0.925284697682223 NA NA NA 0.933836638301768 99.8785170793048 a10708 loss_cnaBRCA28_(GPS2) 333 T0901317 LXR 4 44 2.32630161961136 NA 4.7701296094799 4.73228226026151 0.0378473492183913 0.586336473126178 0.781417602806561 0.0491394752945758 0.064548857103499 0.048434216329985 0.925442417375861 NA NA NA 0.910372170109337 99.8785170793048 a10709 POLR2B_mut 228 KIN001-102 AKT1 3 46 2.32630161961136 NA 2.01821408007027 1.93884421658293 0.0793698634873423 1.52626334581279 1.41201194439753 0.0560101807747359 0.0520027318385706 0.0562104759823456 0.925512063205889 NA NA NA 0.937397820724344 99.8785170793048 a10710 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1007 Docetaxel Microtubules 7 38 -4.38202663467388 NA -4.638093646311 -4.57791918354065 -0.06017446277035 1.54527536164738 1.55747210887446 0.0386781025322892 0.0389409319942818 0.038635980976787 0.925516424691338 NA NA NA 0.926879438744806 99.8785170793048 a10711 gain_cnaBRCA48 1021 Axitinib PDGFR, KIT, VEGFR 5 40 0.693147180559945 NA 2.41559251753413 2.46819677850897 -0.0526042609748361 1.21819111276371 1.17575321667021 0.0445887497771219 0.0431822728171879 0.0447409033026624 0.925544749592609 NA NA NA 0.930749864661464 99.8785170793048 a10712 gain_cnaBRCA64_(SDHC) 304 SB52334 ALK5 8 41 2.99573227355399 NA 4.34081363589968 4.29429723307359 0.0465164028260912 1.30713414506003 1.27838753172277 0.0362641681049541 0.0355865562856632 0.0363867776177426 0.925647351514871 NA NA NA 0.92824224955906 99.8785170793048 a10713 gain_cnaBRCA10_(MDM2,NUP107) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 3 40 0.693147180559945 NA 1.59385293412995 1.68855407821293 -0.0947011440829866 1.29333769414335 1.70284487610776 0.0561964817789186 0.073222287196781 0.0556134885870799 0.925663061941564 NA NA NA 0.913788415420246 99.8785170793048 a10714 loss_cnaBRCA24 1375 Temozolomide DNA akylating agent 3 43 3.40119738166216 NA 5.86329914761909 5.90269524619311 -0.0393960985740183 0.898140888908484 0.692886511124224 0.0559988193273837 0.0438640519104932 0.0568579384091303 0.925712297313951 NA NA NA 0.946958886265893 99.8785170793048 a10715 gain_cnaBRCA15 258 STF-62247 stimulates autophagy 22 27 2.32630161961136 NA 4.64519996817286 4.61914455792299 0.0260554102498771 0.97055213527519 0.966601653806117 0.0269064962445865 0.0268459666440169 0.0269556855683834 0.925760650624046 NA NA NA 0.925810224552305 99.8785170793048 a10716 TP53_mut 272 AR-42 HDAC 38 11 1.63315443905142 NA 0.153064111528974 0.103638741546418 0.0494253699825564 1.51075215162617 1.64924833495887 0.0320681161653253 0.0327157369455705 0.0299684219379787 0.925775780285166 NA NA NA 0.930122951295856 99.8785170793048 a10717 gain_cnaBRCA9_(KRAS) 134 Etoposide TOP2 4 43 2.77258872223978 NA 2.37991096771119 2.48614269498278 -0.106231727271585 2.18757784418198 2.17473955189598 0.0488287529595154 0.048561347224336 0.0488480228259843 0.925992920468816 NA NA NA 0.930919280669497 99.8785170793048 a10718 loss_cnaBRCA17 1194 SB-505124 TGFR1 (ALK5) 9 38 2.30258509299405 NA 4.41487793775597 4.38286988828193 0.0320080494740438 0.905364855309185 0.929307609273952 0.034599690493565 0.0353537574231473 0.0344429004504235 0.926053141429884 NA NA NA 0.925933967836405 99.8785170793048 a10719 loss_cnaBRCA38 1264 SGC0946 Q8TEK3 (DOT1L) 3 43 -0.693147180559945 NA 1.91890445155203 1.95293291065384 -0.0340284591018036 0.0919799198665414 0.625781429219833 0.0556285864485066 0.369955302757138 0.0543775470362347 0.926201990075357 NA NA NA 0.75805854639466 99.8785170793048 a10720 loss_cnaBRCA24 185 OSI-906 IGF1R 3 45 0.940007258491471 NA 2.95265067491272 2.88954586177561 0.0631048131371106 0.616644445976671 1.15443135854239 0.0555327068319802 0.102335816934444 0.0546631141558628 0.926203795800444 NA NA NA 0.883234533931731 99.8785170793048 a10721 ARID1A_mut 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 5 40 2.30258509299405 NA 1.40895803615976 1.35986976272718 0.0490882734325766 0.643921407938091 1.14834056798858 0.0441790817037604 0.0762333303838473 0.0427471386111169 0.926226791363228 NA NA NA 0.889055225753831 99.8785170793048 a10722 loss_cnaBRCA23 1069 EHT 1864 Rac GTPases 3 43 2.30258509299405 NA 3.51643541386581 3.56456027033224 -0.0481248564664227 1.04751152493142 0.855855656727132 0.0556042705309841 0.0459420782693282 0.0562301085330866 0.926234152816601 NA NA NA 0.944530369761779 99.8785170793048 a10723 gain_cnaBRCA48 1031 Elesclomol HSP70 5 39 -1.6094379124341 NA -2.90702767538239 -2.98662412123592 0.079596445853531 1.81360378061946 1.7984668663132 0.0442223614830378 0.0438885531140344 0.0442579439991025 0.926269655006476 NA NA NA 0.929863458559229 99.8785170793048 a10724 PIK3CA_mut 3 Rapamycin MTOR 4 10 -2.30258509299405 NA -2.85116772225302 -2.6986618994208 -0.152505822832226 4.01959889406038 2.13031175178429 0.0559002099835312 0.0379405574664622 0.0715884999951255 0.926280466152234 NA NA NA 0.94636646899423 99.8785170793048 a10725 CDH1_mut 1067 CCT007093 PPM1D 5 41 1.88706964903238 NA 4.12462422590073 4.08088158951669 0.043742636384045 0.704496618472669 1.01775504555816 0.0440346966660183 0.0620906264658557 0.0429795328207441 0.926357855683243 NA NA NA 0.90523702717432 99.8785170793048 a10726 gain_cnaBRCA31 1170 CCT018159 HSP90 13 30 2.30258509299405 NA 3.36863241436558 3.33164667514282 0.0369857392227644 1.45524292758749 1.07880796660194 0.0307891970451266 0.0254155086560562 0.0342838951581559 0.926573720456471 NA NA NA 0.935275359065675 99.8785170793048 a10727 loss_cnaBRCA7_(FAS,PTEN) 299 OSI-027 MTORC1/2 4 44 2.99573227355399 NA 1.1803788837477 1.2770232618016 -0.0966443780538997 2.42157447696475 1.96697016536301 0.0483277248391848 0.0399097277301318 0.0491336268112961 0.926670439740966 NA NA NA 0.942581831247927 99.8785170793048 a10728 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 193 GW-2580 CSF1R (cFMS) 9 39 2.99573227355399 NA 5.48427597701154 5.45856876533935 0.0257072116721879 0.238201361941161 0.81941654435048 0.0342143418495759 0.107922185929978 0.0313725807093205 0.926685747647032 NA NA NA 0.8676615931058 99.8785170793048 a10729 gain_cnaBRCA30_(CRNKL1,FOXA2) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 5 44 1.63315443905142 NA 3.61610258725595 3.57217443352738 0.0439281537285763 1.76674767015637 0.904810080488825 0.0436097199597716 0.0248638526432517 0.0485495847977777 0.926768833132008 NA NA NA 0.958792713354112 99.8785170793048 a10730 loss_cnaBRCA29_(MAP2K4) 1006 Cytarabine DNA synthesis 6 39 0.693147180559945 NA 1.26265620856809 1.20020666959796 0.0624495389701287 1.72268164012839 1.51509243819533 0.040534053522029 0.0362513522611608 0.0412183028545204 0.926784228303891 NA NA NA 0.93572659856135 99.8785170793048 a10731 PTEN_mut 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 7 38 2.30258509299405 NA 1.40095374023933 1.35876064495291 0.0421930952864111 0.665878230897748 1.16743098466801 0.0379734059270946 0.063364581283166 0.0361418326569512 0.926869503056939 NA NA NA 0.89534360468207 99.8785170793048 a10732 gain_cnaBRCA48 269 NSC-207895 MDM4 5 44 2.99573227355399 NA 4.55718336356987 4.60925592630466 -0.0520725627347902 1.18244904148987 1.19796485060673 0.0435152028617357 0.0440378916195658 0.0434675213620979 0.926927090704164 NA NA NA 0.92938694869733 99.8785170793048 a10733 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 219 AT-7519 CDK9 9 40 2.32630161961136 NA 1.62132452287646 1.68340259897651 -0.0620780761000463 1.31634091856368 1.91312372677478 0.0340083996324112 0.0471595733480521 0.0324485422616654 0.926946366172714 NA NA NA 0.908665243649984 99.8785170793048 a10734 gain_cnaBRCA8_(CHD4,WNK1) 1033 Vismodegib SMO 3 42 2.30258509299405 NA 4.80029898158698 4.75687996883152 0.0434190127554643 0.51402917788527 0.799646928206931 0.0550542018892364 0.0844679925254269 0.0542977296903071 0.927027935219166 NA NA NA 0.901820319161725 99.8785170793048 a10735 loss_cnaBRCA24 207 AS601245 JNK 3 45 2.07944154167984 NA 2.33266378311478 2.26176984181954 0.0708939412952394 1.04298565464744 1.30330280718121 0.0548258600522869 0.0679721154162986 0.054395602391565 0.927140390542827 NA NA NA 0.919357081709016 99.8785170793048 a10736 gain_cnaBRCA16 207 AS601245 JNK 16 32 2.07944154167984 NA 2.29046832530113 2.25406690707518 0.0364014182259558 1.52825763644271 1.16231678677592 0.0281510522015134 0.023818901576495 0.0313179837374003 0.927144191921106 NA NA NA 0.933824373813094 99.8785170793048 a10737 gain_cnaBRCA10_(MDM2,NUP107) 1494 SN-38 TOP1 3 45 -2.99573227355399 NA -3.21692845894982 -3.30957917998851 0.0926507210386904 1.0076987029147 1.72089312262827 0.0546247117418727 0.091942880119528 0.0538387421161796 0.927406937650415 NA NA NA 0.893842962382649 99.8785170793048 a10738 gain_cnaBRCA9_(KRAS) 1194 SB-505124 TGFR1 (ALK5) 4 43 2.30258509299405 NA 4.34847514969497 4.3927687580404 -0.0442936083454253 0.674949097615881 0.940424902726638 0.0478798205292624 0.0656251093628887 0.047099569797654 0.927427018658774 NA NA NA 0.909449296300438 99.8785170793048 a10739 TP53_mut 1022 AZD7762 CHEK1, CHEK2 35 10 0.693147180559945 NA 0.892867712245825 0.946341092422489 -0.0534733801766638 1.67441342386209 1.48050742285967 0.032690803068136 0.0319355897501858 0.0361182790109742 0.927780675101304 NA NA NA 0.923334547664101 99.8785170793048 a10740 NF1_mut 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 39 1.6094379124341 NA 2.49751048492828 2.57450354258214 -0.0769930576538602 2.01211814949172 1.58146604722248 0.0476185447312531 0.0382646802690536 0.0486846099472591 0.928173155326245 NA NA NA 0.945005399159053 99.8785170793048 a10741 loss_cnaBRCA29_(MAP2K4) 1067 CCT007093 PPM1D 7 39 1.88706964903238 NA 4.05434129108889 4.09125326312989 -0.0369119720409987 0.7613624269527 1.02521730517109 0.0371582366848347 0.0484814731254027 0.0360040470003955 0.928282695062073 NA NA NA 0.913414915259774 99.8785170793048 a10742 POLR2B_mut 1058 GDC0941 PI3K (class 1) 3 40 1.38629436111989 0.693147180559945 1.41649890958683 1.34071534404234 0.0757835655444916 1.09032380192595 1.4121775322207 0.0542009101250974 0.0695055591840034 0.0536643331418246 0.928295295797856 NA NA NA 0.918042678685549 99.8785170793048 a10743 POLR2B_mut 224 AS605240 PI3Kgamma 3 46 2.99573227355399 2.32630161961136 3.1897194950812 3.27550917894838 -0.0857896838671843 0.663366427957054 1.62126110758785 0.0538784398533816 0.129324729518477 0.0529154023776123 0.928339028792677 NA NA NA 0.858920855567197 99.8785170793048 a10744 BRCA1_mut 154 CHIR-99021 GSK3B 4 43 0.940007258491471 NA 3.31491733752422 3.27176425662668 0.0431530808975467 1.20983516957713 0.887932496191195 0.0472687332336759 0.0356685621171269 0.0485995062492393 0.928350669137908 NA NA NA 0.948499368472807 99.8785170793048 a10745 gain_cnaBRCA48 1042 BIRB 0796 p38, JNK2 4 39 2.30258509299405 NA 4.32647893874952 4.37071007931218 -0.0442311405626521 0.802722619748184 0.94100890138386 0.0474793599859275 0.0551014005018664 0.0470039555392146 0.928382512342415 NA NA NA 0.922914415821756 99.8785170793048 a10746 NF1_mut 135 Gemcitabine DNA replication 5 42 0.0237165266173161 NA -0.381587684596649 -0.262561354155893 -0.119026330440756 2.49985491360934 2.8107905314827 0.0427451412486419 0.0476132953927727 0.0423462115399859 0.928406877244624 NA NA NA 0.924590071095333 99.8785170793048 a10747 gain_cnaBRCA14_(RAD21) 173 FH535 unknown 21 27 3.46573590279973 NA 1.5539354711118 1.58782453615263 -0.0338890650408326 1.53812901523661 1.05978154702141 0.026275780603433 0.0220326544165864 0.031977406226859 0.92843450084315 NA NA NA 0.931746599861289 99.8785170793048 a10748 BRCA1_mut 1053 MK-2206 AKT1, AKT2 4 38 1.38629436111989 0.693147180559945 1.46500862644522 1.38639172930797 0.0786168971372414 0.576122176948151 1.71707677066267 0.0473895102082982 0.136458724004851 0.0457853128529023 0.928615693258821 NA NA NA 0.848206859161268 99.8785170793048 a10749 MLL3_mut 1373 Dabrafenib BRAF 3 43 2.30258509299405 NA 4.2974492565523 4.2088081925803 0.0886410639719966 0.996589981756344 1.67261652859876 0.0537898124115046 0.0889443658823257 0.0529954490203777 0.928634490407584 NA NA NA 0.897333704712646 99.8785170793048 a10750 POLR2B_mut 1091 BMS-536924 IGF1R 3 44 1.38629436111989 NA 3.07872612908919 3.01952331624711 0.0592028128420852 1.46651305511185 1.0829789044967 0.0536811310211003 0.040369782345763 0.0546666353298901 0.928716543972221 NA NA NA 0.95111586749998 99.8785170793048 a10751 BRCA1_mut 205 BMS-708163 g-secretase 4 44 2.32630161961136 0.940007258491471 4.92595849262366 4.89385415625562 0.0321043363680404 0.70142568405657 0.682886668094741 0.046928545349043 0.0457701180577973 0.0470126858057015 0.928787551195496 NA NA NA 0.934751248932842 99.8785170793048 a10752 gain_cnaBRCA15 133 Doxorubicin DNA intercalating 22 26 0.0237165266173161 NA -1.00463609083574 -1.05265250812473 0.0480164172889899 1.99054599277206 1.72091486258815 0.0259703772304279 0.0241222345343157 0.0279016808633846 0.928953685552964 NA NA NA 0.929858195192878 99.8785170793048 a10753 TP53_mut 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 37 10 2.99573227355399 NA 3.83790807243438 3.88375322332097 -0.0458451508865889 1.44591981371776 1.40859200660494 0.0318694051232754 0.0317065652269551 0.0325467918826881 0.929146362036116 NA NA NA 0.928887640387529 99.8785170793048 a10754 BRCA2_mut 265 Tubastatin A HDAC6 6 43 2.99573227355399 NA 4.65620674164347 4.69672034238753 -0.0405136007440534 0.843724008600316 1.06384352895143 0.0388568306027431 0.0480175985643254 0.0380822927822717 0.929332126707337 NA NA NA 0.918079399172067 99.8785170793048 a10755 loss_cnaBRCA57 164 JQ12 HDAC 5 42 1.63315443905142 NA 1.64018487852827 1.57046630140036 0.0697185771279059 2.11389009082561 1.60210297868979 0.0421509845198988 0.0329811741066803 0.0435169137410394 0.929399312837448 NA NA NA 0.946139668018074 99.8785170793048 a10756 gain_cnaBRCA8_(CHD4,WNK1) 309 Y-39983 ROCK 4 45 2.99573227355399 NA 4.98155880841824 4.93084067114846 0.0507181372697803 1.56054021292834 1.05172955599304 0.0464742157382094 0.0325003718901982 0.0482235542214958 0.929401694839601 NA NA NA 0.952911012356846 99.8785170793048 a10757 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 8 35 0.693147180559945 NA 2.88101362824455 2.91468270843523 -0.0336690801906827 0.909646808940649 0.974615888158247 0.0349324587841163 0.0370133549194691 0.0345459997110327 0.929404453269348 NA NA NA 0.927438737102482 99.8785170793048 a10758 PIK3CA_mut 341 EX-527 SIRT1 17 32 2.99573227355399 NA 5.65325415313175 5.6356433780493 0.0176107750824412 0.771340092161472 0.593357100159772 0.0267087698335156 0.022831401169738 0.0296798927285091 0.929465701259128 NA NA NA 0.935180626926668 99.8785170793048 a10759 MACF1_mut 1007 Docetaxel Microtubules 3 42 -4.38202663467388 NA -4.51002657331691 -4.59279773282788 0.0827711595109699 2.01506789770952 1.52986605529455 0.0532019246967999 0.0410761144103651 0.054103533590092 0.929476307775336 NA NA NA 0.950317088159059 99.8785170793048 a10760 loss_cnaBRCA7_(FAS,PTEN) 288 KIN001-055 JAK3, MNK1 4 45 2.32630161961136 NA 4.3023529954993 4.34226512243641 -0.0399121269371117 0.930049762898213 0.856654403965197 0.0463272432232764 0.0429139692619649 0.0465906983637396 0.92962435917801 NA NA NA 0.938590459476109 99.8785170793048 a10761 NF1_mut 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 5 43 2.07944154167984 NA 3.17045589841563 3.21940200342099 -0.0489461050053608 1.04697090026784 1.1808099637421 0.0418421515196635 0.0467502057534162 0.0414512974215137 0.929820067006028 NA NA NA 0.925883764883884 99.8785170793048 a10762 gain_cnaBRCA30_(CRNKL1,FOXA2) 303 PIK-93 PI4K, PI3K 5 44 2.99573227355399 NA 2.73789562267136 2.79762169705352 -0.0597260743821639 1.34555019621965 1.44017982743146 0.0416973888673046 0.044387845618815 0.0414712616053543 0.929971375743107 NA NA NA 0.929171515093216 99.8785170793048 a10763 loss_cnaBRCA24 202 GSK-1904529A IGF1R 3 45 0.0237165266173161 NA 2.14836649681383 2.19242828677524 -0.0440617899614066 0.168182281089999 0.857212809554549 0.05251053625806 0.26198830028847 0.0514012267085735 0.930208992320499 NA NA NA 0.787938286890423 99.8785170793048 a10764 gain_cnaBRCA58_(CCND1) 1161 ZG-10 IRAK1 5 21 2.30258509299405 NA 1.92486845707104 1.98744443964237 -0.0625759825713348 1.43045663820911 1.4204311936605 0.044002302335361 0.0437454592469703 0.0440542159666841 0.93027128530259 NA NA NA 0.932703487432254 99.8785170793048 a10765 loss_cnaBRCA22_(SYNCRIP,ZNF292) 326 GSK690693 AKT 18 30 2.32630161961136 NA 2.97142671485942 2.92046917189935 0.0509575429600684 2.24456463287248 1.74430980060057 0.0262094997915176 0.022702640063813 0.029213585191417 0.930330332293092 NA NA NA 0.934793205425297 99.8785170793048 a10766 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 4 39 -1.38629436111989 0.693147180559945 -2.18031681469252 -2.22463364614004 0.0443168314475217 0.713467974506225 0.977301734713377 0.0461413789542707 0.0621146751235645 0.0453461094699878 0.930395318489741 NA NA NA 0.91459457462767 99.8785170793048 a10767 loss_cnaBRCA33 173 FH535 unknown 6 42 3.46573590279973 NA 1.61623858204582 1.5668208542189 0.0494177278269108 1.09305365157235 1.3117228592306 0.0383156941596166 0.0452107064971821 0.0376739091486879 0.930422853360422 NA NA NA 0.922406110424198 99.8785170793048 a10768 loss_cnaBRCA33 190 Bleomycin DNA damage 6 42 4.15888308335967 NA 2.17094517405411 2.06517829665446 0.105766877399643 2.01926855729385 2.84162726965089 0.038264248000582 0.0523788066810629 0.037220531534608 0.930516029551628 NA NA NA 0.912553483577782 99.8785170793048 a10769 PTEN_mut 262 VX-11e ERK 9 40 1.63315443905142 NA 3.7415883266267 3.7847372586482 -0.043148932021507 1.04170932292206 1.39379504310077 0.032190782196922 0.0414212785390762 0.0309578744989032 0.930840407096952 NA NA NA 0.917810211723381 99.8785170793048 a10770 gain_cnaBRCA9_(KRAS) 1219 PFI-1 BRD2, BRD3, BRD4 4 43 2.30258509299405 NA 3.13052079801658 3.17638434284818 -0.0458635448316 0.879349982836668 1.01399195053432 0.0456091894743217 0.0521561900571718 0.045230679402763 0.930859547705122 NA NA NA 0.926601920779635 99.8785170793048 a10771 PTEN_mut 154 CHIR-99021 GSK3B 8 39 0.940007258491471 NA 3.24982121108218 3.2806913511894 -0.0308701401072224 1.01848211921605 0.892133225796771 0.0338141073493327 0.0303099480342218 0.0346026122720091 0.930961313238343 NA NA NA 0.938168180521219 99.8785170793048 a10772 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 301 PHA-793887 CDK-pan 14 34 2.32630161961136 NA 2.88992914539078 2.93558668998723 -0.0456575445964469 1.50233817387122 1.7101362701043 0.0276033321119184 0.0303909901182878 0.0266981908954322 0.931108470382688 NA NA NA 0.927503140065828 99.8785170793048 a10773 loss_cnaBRCA34 175 PAC-1 CASP3 agonist 5 43 0.940007258491471 NA 2.44669383982885 2.39611295876709 0.0505808810617618 1.11689653910374 1.24221339665482 0.0410618265732619 0.0452869888041292 0.0407183509676938 0.931125475882782 NA NA NA 0.928091648094462 99.8785170793048 a10774 loss_cnaBRCA57 192 LFM-A13 BTK 5 43 2.77258872223978 NA 4.76446716951902 4.79907511899957 -0.0346079494805451 0.762832946946107 0.850297878393946 0.0410507625250876 0.045367664859119 0.040700971224241 0.931143986360116 NA NA NA 0.927980228986033 99.8785170793048 a10775 PIK3CA_mut 253 XMD14-99 EPHB3, CAMK1 16 32 2.32630161961136 NA 4.91931406188265 4.93999572939314 -0.0206816675104893 0.847410981250176 0.743490310797406 0.0265523212616364 0.0244057110045681 0.0278169966846075 0.9312708536052 NA NA NA 0.934502538256956 99.8785170793048 a10776 PIK3CA_mut 186 Bexarotene Retinioic acid X family agonist 17 30 2.07944154167984 NA 3.62370932223173 3.59346660822749 0.0302427140042414 1.45778208306334 0.935763040281004 0.0263237947680269 0.020745702911021 0.0323187737732831 0.931284275237699 NA NA NA 0.939258674496397 99.8785170793048 a10777 gain_cnaBRCA9_(KRAS) 305 TPCA-1 IKK 4 45 2.99573227355399 NA 4.23600229024521 4.17319961680641 0.0628026734387976 0.462151424378847 1.43269811893764 0.0451451290054702 0.135891982856501 0.0438352452681143 0.931415475375731 NA NA NA 0.845871015020903 99.8785170793048 a10778 loss_cnaBRCA7_(FAS,PTEN) 1020 Lenalidomide TNFA 4 41 1.6094379124341 NA 4.28430863477967 4.25184052245531 0.0324681123243611 0.42372543084262 0.733235131994801 0.0453467600247282 0.0766253568019153 0.0442806282836312 0.931416048764312 NA NA NA 0.89803831159656 99.8785170793048 a10779 gain_cnaBRCA16 330 XMD13-2 RIPK 16 32 2.32630161961136 NA 3.69941644248895 3.73182364524446 -0.0324072027555085 1.45853382194899 1.09539307269574 0.0264400156028135 0.0222190272641081 0.0295849988130333 0.931560811293209 NA NA NA 0.938092768230083 99.8785170793048 a10780 loss_cnaBRCA22_(SYNCRIP,ZNF292) 88 MS-275 HDAC 4 10 1.6094379124341 NA 1.07139999195646 1.16628127483453 -0.0948812828780756 1.22348648830983 1.99007538961001 0.0518815581402034 0.0775499229330667 0.0476772304071703 0.931564879616649 NA NA NA 0.916217433170038 99.8785170793048 a10781 gain_cnaBRCA9_(KRAS) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 4 42 2.30258509299405 NA 1.4545587630669 1.4092335964489 0.0453251666179944 0.702737356134326 1.02147068921836 0.0451913229912955 0.0644980179612518 0.0443724593337842 0.931569197315533 NA NA NA 0.911584426963097 99.8785170793048 a10782 PTEN_mut 1010 Gefitinib EGFR 7 38 -0.693147180559945 NA 1.36839678932908 1.40570063513783 -0.0373038458087498 1.38683409787346 0.984627382720089 0.0355261522107392 0.0268985640502715 0.0378862567336852 0.931570116551588 NA NA NA 0.947588026393032 99.8785170793048 a10783 loss_cnaBRCA38 1008 Methotrexate Dihydrofolate reductase (DHFR) 3 42 -1.6094379124341 NA 0.629768633939901 0.686427320199145 -0.0566586862592442 0.716433380521498 1.11363068393257 0.0515854575783306 0.079084375183638 0.0508774471435766 0.93161354810521 NA NA NA 0.908024127439719 99.8785170793048 a10784 gain_cnaBRCA15 1053 MK-2206 AKT1, AKT2 20 22 1.38629436111989 0.693147180559945 1.37069465033563 1.41495578239869 -0.0442611320630588 1.69399501501843 1.6266219643564 0.0266799616024357 0.0261282540212063 0.0272104601025545 0.931615142279118 NA NA NA 0.931758242992345 99.8785170793048 a10785 gain_cnaBRCA13_(FGFR1,WHSC1L1) 140 Vinorelbine Microtubules 10 37 -2.74887219562247 NA -3.55965788651604 -3.61067096146199 0.0510130749459425 1.99598627022508 1.56329790410211 0.0307513503679104 0.0255578285817517 0.0326317043041405 0.931625663835757 NA NA NA 0.941549648893461 99.8785170793048 a10786 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1230 IOX2 EGLN1 6 41 -2.30258509299405 NA 0.227795550450876 0.252633516483683 -0.0248379660328074 0.560908919729513 0.67006799213469 0.037699944961488 0.0442816385319473 0.0370678294208309 0.931650280564644 NA NA NA 0.924079483693372 99.8785170793048 a10787 BRCA2_mut 1028 VX-702 p38 5 40 0.693147180559945 NA 3.40177665552496 3.42996327883983 -0.0281866233148693 0.605150103042894 0.697323336927801 0.040893487346145 0.046577903850859 0.0404211673727301 0.931698846892193 NA NA NA 0.926624625695946 99.8785170793048 a10788 TP53_mut 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 33 9 -1.38629436111989 0.693147180559945 -0.290429105288815 -0.345536735068954 0.0551076297801393 1.59806908395106 2.1007158137288 0.032218084354878 0.0344838845413939 0.0262327866625246 0.93215231748704 NA NA NA 0.943050717616916 99.8785170793048 a10789 loss_cnaBRCA28_(GPS2) 1268 XAV 939 TNKS1 (tankyrase-1) 4 43 1.6094379124341 NA 3.62273066644092 3.66504380384453 -0.0423131374036161 0.437198172399647 0.972697985281449 0.0447061979623922 0.0967825120845593 0.0435007967980656 0.932224979618607 NA NA NA 0.877757252114845 99.8785170793048 a10790 gain_cnaBRCA47_(EGFR) 1031 Elesclomol HSP70 7 37 -1.6094379124341 NA -3.03092044963178 -2.96748745831595 -0.0634329913158242 2.00224613387588 1.76397158280587 0.0352416663849216 0.0316809158687362 0.0359603249474826 0.932268026348782 NA NA NA 0.939568327699037 99.8785170793048 a10791 loss_cnaBRCA60 287 KIN001-244 PDPK1 (PDK1) 3 46 2.99573227355399 NA 3.43276669151871 3.4810629560097 -0.0482962644909826 0.20444164208358 0.969612519759576 0.0508544973427203 0.236234966608408 0.0498098606471769 0.932350762868321 NA NA NA 0.799236649300469 99.8785170793048 a10792 loss_cnaBRCA36_(FAT1,IRF2) 266 Zibotentan, ZD4054 Endothelin A Receptor 9 40 2.99573227355399 NA 5.75478799295611 5.73917094760104 0.0156170453550688 0.221528836845732 0.535258222086294 0.0314813484477784 0.0704966702188042 0.0291766566316305 0.932360758266737 NA NA NA 0.890297622445819 99.8785170793048 a10793 gain_cnaBRCA47_(EGFR) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 7 41 2.07944154167984 NA 3.17946280685191 3.22025185344433 -0.0407890465924177 0.738883971433758 1.22138025715173 0.0348687776576273 0.0552035883431996 0.0333958620614502 0.932422882791836 NA NA NA 0.905919748399279 99.8785170793048 a10794 BRCA2_mut 277 ABT-869 VEGFR and PDGFR family 6 42 0.0237165266173161 NA 2.67548735585859 2.69330551821987 -0.0178181623612739 0.359884672248471 0.491561767274555 0.037198227024338 0.0495107564597024 0.0362480639209716 0.932446962115654 NA NA NA 0.916853329593303 99.8785170793048 a10795 gain_cnaBRCA27_(CLTC,PPM1D) 197 Bryostatin 1 PRKC 9 39 -4.8283137373023 NA -2.78187617722204 -2.81255647982946 0.0306803026074127 1.23380954043426 0.909476945510632 0.0315098177135123 0.0248663198021748 0.0337340080568915 0.932466054006249 NA NA NA 0.945311748690982 99.8785170793048 a10796 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1066 AZD6482 PI3Kbeta 13 30 1.6094379124341 NA 1.99580785107656 1.95478554563749 0.0410223054390719 1.53491697227001 1.41417629894176 0.0282804069934076 0.0267260745565954 0.0290079146919441 0.932541239563111 NA NA NA 0.935105141598215 99.8785170793048 a10797 TP53_mut 1149 TW 37 BCL2, BCL2L1 34 9 1.6094379124341 NA -0.150786910774131 -0.110640828102228 -0.0401460826719037 1.2766259307654 1.17551066774878 0.031924432684022 0.0314470211707468 0.0341520360242986 0.932546516357084 NA NA NA 0.930048837888391 99.8785170793048 a10798 loss_cnaBRCA29_(MAP2K4) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 7 40 2.99573227355399 NA 3.8050716117779 3.85511574077091 -0.0500441289930071 1.72971461832033 1.38833935918743 0.0347880346394759 0.0289320148323678 0.0360460348990589 0.932709411680724 NA NA NA 0.944070768377551 99.8785170793048 a10799 loss_cnaBRCA17 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 11 38 1.63315443905142 NA 3.5540205692836 3.58320951972012 -0.0291889504365228 0.824082932873265 1.05137173559206 0.0289769366053241 0.0354199186418677 0.0277627307719906 0.932912205019992 NA NA NA 0.923787680503471 99.8785170793048 a10800 PTEN_mut 303 PIK-93 PI4K, PI3K 9 40 2.99573227355399 NA 2.75523759845575 2.79969235994025 -0.0444547614844963 1.15786449829513 1.48242168278643 0.031035575491395 0.0383937512117805 0.029987932584025 0.93331620217371 NA NA NA 0.922916662923581 99.8785170793048 a10801 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1022 AZD7762 CHEK1, CHEK2 7 38 0.693147180559945 NA 0.952558550330376 0.895943973697793 0.0566145766325835 1.31654819678934 1.68181907030548 0.0346106694578296 0.0430022818539035 0.0336627034573346 0.933329193528598 NA NA NA 0.922503952705274 99.8785170793048 a10802 loss_cnaBRCA29_(MAP2K4) 312 AV-951 VEGFR 7 41 -2.05572501506252 NA 0.65121976596083 0.629041521031293 0.0221782449295375 0.810448686617296 0.618103553970826 0.0343079704438352 0.0273653906727969 0.0358811153682256 0.933507126458632 NA NA NA 0.946815020842783 99.8785170793048 a10803 loss_cnaBRCA18 1264 SGC0946 Q8TEK3 (DOT1L) 15 31 -0.693147180559945 NA 1.96158522372389 1.94545323086815 0.0161319928557344 0.610661000724898 0.612212975985812 0.0263715484123943 0.0264172639755684 0.0263502955483065 0.9335590657925 NA NA NA 0.933718778393898 99.8785170793048 a10804 POLR2B_mut 154 CHIR-99021 GSK3B 3 44 0.940007258491471 NA 3.31813214416023 3.27252581710371 0.0456063270565195 0.251001593300064 0.932362416459737 0.0499553054170378 0.181697360789254 0.0489148063579082 0.933651843941221 NA NA NA 0.827526136105893 99.8785170793048 a10805 gain_cnaBRCA8_(CHD4,WNK1) 1036 PLX4720 BRAF 3 40 2.30258509299405 NA 4.6530639644506 4.59238205786621 0.0606819065843851 0.453757166354319 1.23886550206493 0.0500502105624721 0.133732117273055 0.0489818357870495 0.933772796832576 NA NA NA 0.860436123045707 99.8785170793048 a10806 loss_cnaBRCA57 1054 PD-0332991 CDK4, CDK6 5 37 1.38629436111989 0.693147180559945 2.93479036371008 2.87589316731648 0.0588971963935978 0.89341715881164 1.52943503454233 0.0398438748996642 0.0659235115563917 0.0385091194221415 0.933773735036959 NA NA NA 0.903923636437692 99.8785170793048 a10807 NF1_mut 163 JQ1 BRD4 4 43 0.940007258491471 NA 0.25723181101057 0.321375808172555 -0.0641439971619849 1.22802314734305 1.4851745715683 0.0436522433015621 0.0522335407934017 0.0431895336682548 0.93381894647565 NA NA NA 0.926792070266803 99.8785170793048 a10808 gain_cnaBRCA14_(RAD21) 208 SB-715992 KIF11 21 28 -2.05572501506252 NA -1.26358669640813 -1.22213372393622 -0.0414529724719066 1.98441709022866 1.49547642171325 0.024092114269229 0.0208892438369043 0.0277189074130752 0.933842195976109 NA NA NA 0.936552468318797 99.8785170793048 a10809 POLR2B_mut 158 PF-562271 FAK 3 42 0.940007258491471 NA 2.27283174870757 2.33756580961417 -0.0647340609065976 1.58010273777425 1.28397445156776 0.0498243542336388 0.0409682607080239 0.0504169384582037 0.933942602371958 NA NA NA 0.950528892355253 99.8785170793048 a10810 gain_cnaBRCA9_(KRAS) 201 Epothilone B Microtubules 4 44 -3.44201937618241 NA -4.16333548972056 -4.24234178250512 0.079006292784559 1.30089966773004 1.84878785032112 0.0434555165610838 0.0607320416357842 0.0427341042785608 0.934044840968915 NA NA NA 0.916246096121887 99.8785170793048 a10811 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 202 GSK-1904529A IGF1R 6 42 0.0237165266173161 NA 2.16308697445429 2.19347263210955 -0.0303856576552599 0.534597459410327 0.868977793368755 0.0362116945170608 0.0568383876885161 0.0349671279141257 0.93423427974955 NA NA NA 0.908088222080916 99.8785170793048 a10812 loss_cnaBRCA60 1133 JNJ-26854165 MDM2 3 40 2.30258509299405 NA 3.00945597453095 2.96576776632138 0.0436882082095691 0.675404952948514 0.888899675208201 0.0496632862865628 0.0646844652513223 0.0491486378362511 0.934283574183989 NA NA NA 0.923783644166261 99.8785170793048 a10813 gain_cnaBRCA12_(TERT) 219 AT-7519 CDK9 9 40 2.32630161961136 NA 1.6264520176932 1.68224891264274 -0.0557968949495378 2.17654469549155 1.74466473021232 0.0305668323799125 0.0256355383214112 0.0319814426137608 0.934320985921159 NA NA NA 0.944051959114309 99.8785170793048 a10814 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1025 SB 216763 GSK3A, GSK3B 15 24 2.30258509299405 NA 4.90249886658344 4.88082537490748 0.0216734916759593 0.958814374333273 0.674360398699164 0.0272942823135163 0.0226044709551109 0.0321393304200059 0.934357413486329 NA NA NA 0.939681091384197 99.8785170793048 a10815 gain_cnaBRCA15 185 OSI-906 IGF1R 22 26 0.940007258491471 NA 2.90823055600002 2.88101706048615 0.0272134955138705 1.22970445128665 1.05159991016582 0.0239476005759493 0.0221301106012886 0.0258781835665803 0.934473919483097 NA NA NA 0.935369389321159 99.8785170793048 a10816 POLR2B_mut 207 AS601245 JNK 3 45 2.07944154167984 NA 2.32585114145317 2.26222401793032 0.063627123522858 1.29715538878264 1.29291323967882 0.0492051839711813 0.0490512733270692 0.0492122143777133 0.934591569129455 NA NA NA 0.941108154227422 99.8785170793048 a10817 BRCA2_mut 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 5 38 -1.38629436111989 0.693147180559945 -2.25383231284822 -2.21612678668397 -0.0377055261642543 0.876939924637254 0.969067093518078 0.0392574451246094 0.0429967037706159 0.0389090976429393 0.93463396748069 NA NA NA 0.932122001618454 99.8785170793048 a10818 gain_cnaBRCA64_(SDHC) 1259 BMN-673 PARP1 9 37 2.30258509299405 NA 3.34419266947494 3.29613556317754 0.0480571062974042 1.01846449115581 1.66704852234053 0.0306253843421735 0.0471858437036586 0.0288276589753562 0.934702722690078 NA NA NA 0.913394665566146 99.8785170793048 a10819 gain_cnaBRCA64_(SDHC) 279 BIX02189 MAP2K5 (MEK5) 8 41 2.99573227355399 NA 5.00326988725933 5.03205578255225 -0.0287858952929252 1.22506463761102 0.838551736414493 0.0317507290423001 0.0234974501827594 0.0343281088606517 0.934878536438208 NA NA NA 0.950776503077244 99.8785170793048 a10820 loss_cnaBRCA42 223 ZSTK474 PI3K 3 46 1.63315443905142 2.32630161961136 0.979342953066712 0.907968070567259 0.0713748824994531 1.16374689369551 1.47004536124905 0.0489431394404539 0.0613319639228426 0.0485528435930767 0.934887400874582 NA NA NA 0.927194589777145 99.8785170793048 a10821 gain_cnaBRCA47_(EGFR) 175 PAC-1 CASP3 agonist 7 41 0.940007258491471 NA 2.36604725400741 2.40741452800189 -0.0413672739944779 1.23171162288974 1.23185156675383 0.0335818763145194 0.0335851941523661 0.0335813787236467 0.934911118659134 NA NA NA 0.936521499757522 99.8785170793048 a10822 loss_cnaBRCA18 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 12 31 -1.38629436111989 0.693147180559945 -2.20119962919048 -2.22798657767568 0.026786948485201 1.07955231625114 0.912921534790612 0.0278894430849225 0.0248130156194945 0.029342005270305 0.935021365620742 NA NA NA 0.94023024524402 99.8785170793048 a10823 gain_cnaBRCA47_(EGFR) 1495 AZD-2281 PARP1, PARP2 6 39 2.30258509299405 NA 3.96321251668162 4.00414957084358 -0.0409370541619589 1.03386298695503 1.15207882804872 0.0359423792244098 0.0395962082775865 0.0355332058582258 0.935057871455465 NA NA NA 0.931652387685486 99.8785170793048 a10824 gain_cnaBRCA58_(CCND1) 1059 AZD8055 MTORC1/2 8 35 0.693147180559945 NA 0.156948439034294 0.124369543846988 0.0325788951873056 0.889061873929632 1.04045500278425 0.0320593634827303 0.0366441258394173 0.0313121616024957 0.935196886213968 NA NA NA 0.92944283902333 99.8785170793048 a10825 PIK3CA_mut 277 ABT-869 VEGFR and PDGFR family 16 32 0.0237165266173161 NA 2.68309116434886 2.69507178971263 -0.0119806253637691 0.557820498165652 0.435786898167936 0.0250112860650055 0.0214775638456572 0.0274919356551013 0.935250398894694 NA NA NA 0.94066817374062 99.8785170793048 a10826 gain_cnaBRCA8_(CHD4,WNK1) 1066 AZD6482 PI3Kbeta 3 40 1.6094379124341 NA 1.9013622036289 1.97212454555583 -0.0707623419269383 1.96301461680196 1.41930843657051 0.0487825551932924 0.0360477916574155 0.0498569163006752 0.935446328412871 NA NA NA 0.956363593610766 99.8785170793048 a10827 gain_cnaBRCA13_(FGFR1,WHSC1L1) 291 KIN001-266 MAP3K8 (COT) 11 38 2.99573227355399 NA 3.80430592161466 3.77120318161489 0.0331027399997703 1.33439908887551 1.14598716184461 0.0278506917073877 0.0248072261707446 0.0288857860732815 0.93551371601147 NA NA NA 0.94147984427228 99.8785170793048 a10828 gain_cnaBRCA19 231 FMK RSK 4 45 2.99573227355399 2.32630161961136 5.56599511978575 5.59129499315254 -0.025299873366798 1.01244631941396 0.558396529473948 0.0423235383772885 0.024988854106796 0.0453080777393663 0.935692125974769 NA NA NA 0.963617229196967 99.8785170793048 a10829 loss_cnaBRCA7_(FAS,PTEN) 279 BIX02189 MAP2K5 (MEK5) 4 45 2.99573227355399 NA 4.99233263180414 5.0304692367889 -0.0381366049847527 1.00248199994985 0.899716340474505 0.0420644138928873 0.0380421842852644 0.0423873650717955 0.936084975797171 NA NA NA 0.945475192932617 99.8785170793048 a10830 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 154 CHIR-99021 GSK3B 14 33 0.940007258491471 NA 3.29190349596292 3.2684510133807 0.0234524825822198 0.993656241521046 0.878043620175326 0.0256887412880225 0.0236022092975733 0.0267099288046041 0.936164440964606 NA NA NA 0.939680085506373 99.8785170793048 a10831 gain_cnaBRCA13_(FGFR1,WHSC1L1) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 10 38 2.77258872223978 NA -0.404414000317936 -0.444978043964899 0.0405640436469625 1.20440315658723 1.46579326892505 0.0285975035804845 0.0336797885534473 0.027673782181242 0.936217628052065 NA NA NA 0.929084985093264 99.8785170793048 a10832 gain_cnaBRCA58_(CCND1) 1020 Lenalidomide TNFA 9 36 1.6094379124341 NA 4.27190858663855 4.25043107444555 0.021477512193 0.771317399085837 0.702750849686399 0.0299963262480831 0.0278452323498148 0.0305620579506724 0.936222125293239 NA NA NA 0.940704506074814 99.8785170793048 a10833 MACF1_mut 1021 Axitinib PDGFR, KIT, VEGFR 3 42 0.693147180559945 NA 2.5152832376078 2.45857104798109 0.0567121896267109 0.658687174090315 1.19944035056105 0.0480694152630634 0.0860988218041951 0.047282209240487 0.936264086731792 NA NA NA 0.901687980727738 99.8785170793048 a10834 loss_cnaBRCA34 1030 KU-55933 ATM 5 37 2.30258509299405 NA 4.19091493872904 4.22654049238827 -0.0356255536592327 0.280846785957934 0.976101994001756 0.0382963090981071 0.126850494434958 0.0364977777713346 0.936340225968658 NA NA NA 0.862861766883197 99.8785170793048 a10835 gain_cnaBRCA19 1268 XAV 939 TNKS1 (tankyrase-1) 4 43 1.6094379124341 NA 3.62508801854977 3.66482451527627 -0.0397364967264986 1.0916928553866 0.935245805451564 0.0419834299872033 0.0363989711304162 0.042487757223688 0.936343364055362 NA NA NA 0.947767047111162 99.8785170793048 a10836 CDH1_mut 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 4 42 1.63315443905142 NA 1.99817006763524 1.93073067917373 0.0674393884615168 1.82923187087437 1.58700929336339 0.0420265231001843 0.03686759974791 0.0424946399139167 0.93635055961428 NA NA NA 0.947156600718202 99.8785170793048 a10837 loss_cnaBRCA24 226 GSK1070916 AURKB 3 46 0.940007258491471 2.32630161961136 2.31599862477263 2.40968351906381 -0.093684894291183 0.061813914970919 2.00527093494483 0.0477452326302025 1.51559554730125 0.0467193198976679 0.936477539566023 NA NA NA 0.75449813513491 99.8785170793048 a10838 gain_cnaBRCA12_(TERT) 271 VNLG/124 HDAC, RAR 9 40 1.63315443905142 NA 4.13179345850791 4.15586060123331 -0.0240671427253991 0.687386761715742 0.843674955911658 0.0293795124843115 0.0350125199754017 0.0285265581925359 0.93686656895699 NA NA NA 0.928956790687238 99.8785170793048 a10839 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 298 OSI-930 KIT, VEGFR, PDGFR 14 34 2.32630161961136 NA 3.89760846427839 3.91985622733322 -0.0222477630548261 0.91541060947899 0.866275835208342 0.0252689214015019 0.0243035888206371 0.0256820774060672 0.936921486893517 NA NA NA 0.938713970419158 99.8785170793048 a10840 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1219 PFI-1 BRD2, BRD3, BRD4 6 41 2.30258509299405 NA 3.14202290680757 3.1769383535047 -0.0349154466971258 0.954421829087753 1.0118056562947 0.0347213060956899 0.0365828249449181 0.0345080564433572 0.93703843295967 NA NA NA 0.936225693882671 99.8785170793048 a10841 gain_cnaBRCA47_(EGFR) 200 LAQ824 HDAC 7 41 0.0237165266173161 NA -2.645156730525 -2.69117898928791 0.046022258762918 1.32511345267151 1.43525577308624 0.0323787232059053 0.0347308063850187 0.0320655451285563 0.937238021206209 NA NA NA 0.935079107715062 99.8785170793048 a10842 POLR2B_mut 1021 Axitinib PDGFR, KIT, VEGFR 3 42 0.693147180559945 NA 2.51441546884581 2.45863303146409 0.0557824373817231 1.15926516167674 1.18079326737241 0.0472812389095175 0.0481187904422489 0.0472414934291204 0.937306893156519 NA NA NA 0.942349922377668 99.8785170793048 a10843 PTEN_mut 211 TL-2-105 CRAF 9 40 2.32630161961136 1.63315443905142 3.93359025939454 3.90169551887284 0.031894740521706 1.49752971341109 0.994203881682051 0.0290925849640992 0.021298235511505 0.0320806839616686 0.937481835086153 NA NA NA 0.952647835036263 99.8785170793048 a10844 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1017 Olaparib PARP1, PARP2 17 28 1.6094379124341 NA 4.06057665152368 4.0823075473535 -0.0217308958298279 1.08575744278484 0.762651020220617 0.0242374371978947 0.020014503215461 0.0284938920340547 0.937534645147559 NA NA NA 0.942853792817285 99.8785170793048 a10845 CDH1_mut 1007 Docetaxel Microtubules 4 41 -4.38202663467388 NA -4.52877315240145 -4.59298760705161 0.0642144546501644 1.51766404270801 1.55864793961641 0.0412736079752839 0.0423113764595654 0.0411988191932349 0.93756274353346 NA NA NA 0.940003030222379 99.8785170793048 a10846 loss_cnaBRCA20 1013 Nilotinib ABL 3 37 0.693147180559945 NA 3.1607043223428 3.20632925214038 -0.0456249297975795 0.438152885478336 0.987488489223329 0.047211584871887 0.104130159379803 0.046202999118971 0.937726397138797 NA NA NA 0.8867899852422 99.8785170793048 a10847 gain_cnaBRCA27_(CLTC,PPM1D) 1230 IOX2 EGLN1 10 37 -2.30258509299405 NA 0.234982526275013 0.253376276102328 -0.0183937498273143 0.465090767580021 0.698938071606801 0.0279182810815963 0.0395487313648933 0.0263167089825692 0.937911048528114 NA NA NA 0.922412844837028 99.8785170793048 a10848 gain_cnaBRCA9_(KRAS) 283 GSK2126458 PI3K, MTOR 4 44 -2.05572501506252 0.0237165266173161 -2.99365382026495 -3.06096736616546 0.0673135459005052 1.63001712804215 1.64746953860891 0.0408868578096115 0.0412962199859563 0.0408587499331511 0.937935068234713 NA NA NA 0.941242548350313 99.8785170793048 a10849 gain_cnaBRCA14_(RAD21) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 20 25 2.30258509299405 NA 1.35083625058008 1.37691422713138 -0.0260779765513048 1.0995120846567 1.12028343069159 0.0234692882952621 0.0237177716509111 0.0232780168275862 0.938007249403437 NA NA NA 0.937891529141208 99.8785170793048 a10850 PIK3CA_mut 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 16 31 2.77258872223978 NA 4.99457154267932 5.01932983916823 -0.0247582964889084 1.22105062225759 0.924155664677265 0.0239755192365507 0.0202762244558977 0.02679017987468 0.938263955501249 NA NA NA 0.943783808436695 99.8785170793048 a10851 loss_cnaBRCA60 229 LY317615 PRKCB (PKCbeta) 3 46 2.99573227355399 2.32630161961136 3.28798904886485 3.36318703003656 -0.0751979811717125 0.238352228537346 1.66074073678984 0.046253894992463 0.315490992608572 0.0452797835964859 0.938457552232401 NA NA NA 0.79120073030418 99.8785170793048 a10852 loss_cnaBRCA29_(MAP2K4) 309 Y-39983 ROCK 7 42 2.99573227355399 NA 4.90541345391473 4.93990883947502 -0.0344953855602883 0.950399173325109 1.11046637218674 0.0316082766784935 0.0362956813604974 0.0310638722831019 0.938614800491256 NA NA NA 0.932834225455703 99.8785170793048 a10853 gain_cnaBRCA47_(EGFR) 1025 SB 216763 GSK3A, GSK3B 6 33 2.30258509299405 NA 4.9122695847272 4.88495983297479 0.027309751752413 0.523969788778221 0.828362517504517 0.0343918417000147 0.0521208518836424 0.0329683576638463 0.938649864827767 NA NA NA 0.917735621072042 99.8785170793048 a10854 loss_cnaBRCA7_(FAS,PTEN) 226 GSK1070916 AURKB 4 45 0.940007258491471 2.32630161961136 2.47669489504993 2.39748129269008 0.0792136023598511 1.02131916454911 2.01037112224009 0.0403699493665548 0.0775600861213864 0.0394024772259891 0.938654287339576 NA NA NA 0.898436852439594 99.8785170793048 a10855 gain_cnaBRCA14_(RAD21) 1052 RO-3306 CDK1 19 24 1.6094379124341 NA 3.54174475616238 3.51295017254042 0.0287945836219663 1.1589178189384 1.25087213338721 0.0237704239101427 0.0248460962040802 0.0230196059640357 0.938675612943176 NA NA NA 0.938127818483189 99.8785170793048 a10856 PTEN_mut 1017 Olaparib PARP1, PARP2 7 38 1.6094379124341 NA 4.09810489347864 4.06967579335395 0.0284291001246908 0.986053133722835 0.881223170853911 0.0317081432909393 0.0288312050866437 0.0322609539387654 0.938908510565469 NA NA NA 0.944999121967509 99.8785170793048 a10857 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1052 RO-3306 CDK1 8 35 1.6094379124341 NA 3.49588995357854 3.53248099655505 -0.0365910429765135 1.08014266972366 1.23665120885667 0.0302065165509003 0.0338761202590718 0.0295888143030589 0.938934309356617 NA NA NA 0.934449523014163 99.8785170793048 a10858 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1008 Methotrexate Dihydrofolate reductase (DHFR) 7 38 -1.6094379124341 NA 0.711963539493848 0.677250225624391 0.0347133138694572 0.589357760113633 1.16004973187087 0.0316045093581129 0.0589002405987905 0.0299239876668679 0.939107777725348 NA NA NA 0.906699053765673 99.8785170793048 a10859 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 225 Genentech Cpd 10 AURKA, AURKB 9 40 2.32630161961136 NA 2.98053572030739 3.0265071853681 -0.0459714650607084 0.684897759471587 1.75741861223918 0.0282792438249136 0.067121646150772 0.0261585172369005 0.939226111768427 NA NA NA 0.899037317529894 99.8785170793048 a10860 gain_cnaBRCA9_(KRAS) 208 SB-715992 KIF11 4 45 -2.05572501506252 NA -1.1770662604876 -1.2454844411741 0.0684181806864936 1.28405826330262 1.7464208466896 0.0397635741233907 0.0532827696700624 0.0391762276636715 0.939573893954079 NA NA NA 0.926016555545907 99.8785170793048 a10861 loss_cnaBRCA20 308 XL-880 MET 3 46 1.63315443905142 NA 1.77894315834898 1.85221525110955 -0.073272092760569 1.29789721363158 1.62885104113307 0.0453374585867494 0.0564544649537772 0.0449839125311295 0.939674478203191 NA NA NA 0.932934971604372 99.8785170793048 a10862 gain_cnaBRCA13_(FGFR1,WHSC1L1) 309 Y-39983 ROCK 11 38 2.99573227355399 NA 4.91298607701175 4.94134785758486 -0.0283617805731096 1.13080034571611 1.08043150880083 0.0259879624392242 0.0250811566166871 0.0262504197092402 0.939817977458884 NA NA NA 0.941959902348446 99.8785170793048 a10863 gain_cnaBRCA9_(KRAS) 172 Embelin XIAP 4 44 3.46573590279973 NA 3.02848737487847 2.98984170751643 0.0386456673620379 1.81083133168347 0.88788958799114 0.0396331647362312 0.0213413953502286 0.0435253075210333 0.939834345066904 NA NA NA 0.968868588313082 99.8785170793048 a10864 gain_cnaBRCA8_(CHD4,WNK1) 221 TAK-715 p38a 4 45 2.99573227355399 2.32630161961136 4.51901855823707 4.47887574995415 0.0401428082829129 1.31232185385067 0.990446923452596 0.039586643850535 0.0305891486643495 0.040529994422093 0.939842235695604 NA NA NA 0.955828890469432 99.8785170793048 a10865 gain_cnaBRCA31 1059 AZD8055 MTORC1/2 13 30 0.693147180559945 NA 0.148243526152968 0.122711856897679 0.025531669255289 0.7457614794575 1.10900201798207 0.0251242223910176 0.034235703986564 0.0230222027023415 0.940054225865418 NA NA NA 0.930237856744653 99.8785170793048 a10866 loss_cnaBRCA18 1066 AZD6482 PI3Kbeta 13 30 1.6094379124341 NA 1.99255465307779 1.95619526477029 0.0363593883074993 1.79552514704058 1.28096045352138 0.025065358600843 0.0202500022722754 0.0283844737029521 0.94019440005319 NA NA NA 0.948056359320694 99.8785170793048 a10867 loss_cnaBRCA24 136 Mitomycin C DNA crosslinker 3 45 2.77258872223978 NA -0.0715023437833529 -0.138492148512415 0.0669898047290622 0.878899067087589 1.51164538552219 0.0449676403551632 0.0762201340718753 0.0443158199473621 0.940213119001324 NA NA NA 0.911933448311699 99.8785170793048 a10868 BRCA2_mut 1067 CCT007093 PPM1D 5 41 1.88706964903238 NA 4.11724331155221 4.08178170102261 0.0354616105296035 0.803700195725227 1.01041405167014 0.0356971785828628 0.0441229337982235 0.0350961177459755 0.940271118390657 NA NA NA 0.931124307827051 99.8785170793048 a10869 loss_cnaBRCA24 224 AS605240 PI3Kgamma 3 46 2.99573227355399 2.32630161961136 3.33712496306503 3.26589577886248 0.0712291842025459 1.74628209600796 1.58513572964989 0.0447328100888539 0.0407890479810663 0.0449357003758148 0.940477464195802 NA NA NA 0.950833913309863 99.8785170793048 a10870 loss_cnaBRCA36_(FAT1,IRF2) 253 XMD14-99 EPHB3, CAMK1 9 39 2.32630161961136 NA 4.9505658061873 4.9290716942312 0.0214941119561001 0.423554901525372 0.834671188900165 0.0275947990300831 0.0507469324016606 0.0257515920543784 0.94083995569006 NA NA NA 0.912863270555732 99.8785170793048 a10871 loss_cnaBRCA34 1114 Cetuximab EGFR 5 40 4.18661983833127 NA 6.25476785561822 6.28606220507244 -0.0312943494542122 0.961864818223209 0.876507560163907 0.0353690312244855 0.0325350806696727 0.035703456395014 0.940907059198711 NA NA NA 0.947548177793586 99.8785170793048 a10872 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 224 AS605240 PI3Kgamma 9 40 2.99573227355399 2.32630161961136 3.30598038119833 3.26221893215211 0.0437614490462241 0.66185027192796 1.72213599306296 0.0274827068736941 0.0661198626069122 0.0254111459388238 0.940934642301698 NA NA NA 0.901349468826766 99.8785170793048 a10873 PIK3CA_mut 292 Masitinib KIT 16 32 2.99573227355399 NA 4.02700638408728 4.00198788004196 0.0250185040453195 1.07374206395088 1.10913687538987 0.0227913245221223 0.0233002923935594 0.0225567327175243 0.94098610539979 NA NA NA 0.940489416410449 99.8785170793048 a10874 BRCA2_mut 312 AV-951 VEGFR 6 42 -2.05572501506252 NA 0.613910478031232 0.634899472757653 -0.0209889947264212 0.396395212640951 0.670602658189413 0.0324677650395005 0.0529496675466481 0.0312987049336939 0.941020257700733 NA NA NA 0.915209088912038 99.8785170793048 a10875 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 298 OSI-930 KIT, VEGFR, PDGFR 7 41 2.32630161961136 NA 3.9362292786476 3.90946403118765 0.0267652474599505 0.980137297142324 0.864503066047242 0.0303995959146803 0.0273076512219124 0.0309602689812645 0.941066855801403 NA NA NA 0.947613844848225 99.8785170793048 a10876 gain_cnaBRCA27_(CLTC,PPM1D) 1262 UNC1215 LMBL3 10 36 0 NA 2.74507412011992 2.76097758476957 -0.0159034646496443 0.662754496426432 0.581046499736058 0.0265647738825431 0.0239960116987447 0.0273703819864133 0.941096312656022 NA NA NA 0.946122410143426 99.8785170793048 a10877 gain_cnaBRCA14_(RAD21) 266 Zibotentan, ZD4054 Endothelin A Receptor 21 28 2.99573227355399 NA 5.73596902067289 5.74659215737557 -0.0106231367026792 0.600767348457352 0.401301720842425 0.0214140596709658 0.0176826132944097 0.02647169486435 0.941181603522962 NA NA NA 0.94450603288099 99.8785170793048 a10878 PTEN_mut 299 OSI-027 MTORC1/2 9 39 2.99573227355399 NA 1.22448519950129 1.27923518612178 -0.0547499866204908 1.76354626945003 2.04610935640194 0.0273772121079421 0.0310453927798361 0.0267580940623662 0.941305563277537 NA NA NA 0.936357374970144 99.8785170793048 a10879 gain_cnaBRCA8_(CHD4,WNK1) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 3 44 -2.30258509299405 NA -0.183790880768135 -0.137661378552147 -0.0461295022159879 0.69034063125012 1.05876324866352 0.0441367152663611 0.0668213634368488 0.0435692325684872 0.941364462425009 NA NA NA 0.92194111999448 99.8785170793048 a10880 NF1_mut 167 OSU-03012 PDPK1 (PDK1) 5 43 2.77258872223978 NA 2.21066257833543 2.25231814958999 -0.041655571254557 0.965209868656911 1.21243555521956 0.0349174391367591 0.0431570092756311 0.0343569363956946 0.941410845692917 NA NA NA 0.932409674256482 99.8785170793048 a10881 loss_cnaBRCA38 326 GSK690693 AKT 4 44 2.32630161961136 NA 3.00827679265915 2.93333292849576 0.0749438641633957 1.55268413289903 1.96870406404817 0.0385456676605705 0.0482672956948864 0.0380676128687882 0.941482130741726 NA NA NA 0.932554739703243 99.8785170793048 a10882 MACF1_mut 1049 PD-173074 FGFR1, FGFR3 3 40 0.693147180559945 NA 2.89038410424836 2.94131748132303 -0.0509333770746712 1.40100687992424 1.13818212716412 0.0441978704355434 0.0363548372277983 0.0447497600419855 0.94150134558232 NA NA NA 0.956117270545868 99.8785170793048 a10883 loss_cnaBRCA38 345 KIN001-270 CDK9 4 45 2.99573227355399 NA 5.08307831021924 5.10976553732843 -0.0266872271091865 0.170238234320561 0.717329035865266 0.038377382886646 0.15676400319645 0.0372036063993917 0.941676451499046 NA NA NA 0.847497027733594 99.8785170793048 a10884 gain_cnaBRCA9_(KRAS) 279 BIX02189 MAP2K5 (MEK5) 4 45 2.99573227355399 NA 5.05929307331376 5.0245171975436 0.0347758757701602 0.733748262888157 0.917236323151645 0.0383571057436738 0.047394832163931 0.0379137577660133 0.941707210766846 NA NA NA 0.933611996289769 99.8785170793048 a10885 loss_cnaBRCA24 1261 rTRAIL TR10A (DR4), TR10B (DR5) 3 44 -2.30258509299405 NA -0.097748308124959 -0.143527917596 0.0457796094710412 0.760194164907782 1.05653628773117 0.0438018975903599 0.0602209429963128 0.0433298978962185 0.941808447887437 NA NA NA 0.92905345015323 99.8785170793048 a10886 gain_cnaBRCA16 106 XMD8-85 MAP2K5 (ERK5) 3 10 2.07944154167984 NA 3.17676278251649 3.23824318064367 -0.0614803981271832 1.47170538054069 1.20700826028465 0.0488218557184879 0.0417749360300604 0.0509361867272426 0.942210048377704 NA NA NA 0.951712463019062 99.8785170793048 a10887 gain_cnaBRCA16 35 NVP-TAE684 ALK 3 11 0.693147180559945 NA 1.82052805967783 1.76008367456058 0.0604443851172547 1.49014178759727 1.20113998902098 0.0482035301475211 0.0405628414828339 0.0503225150022036 0.942224302701497 NA NA NA 0.952779105040396 99.8785170793048 a10888 loss_cnaBRCA18 35 NVP-TAE684 ALK 6 8 0.693147180559945 NA 1.80167237386119 1.75155879450409 0.0501135793571021 0.608132898833147 1.55927140386161 0.0399648591842626 0.0824056377368457 0.0321390998597123 0.942229202897843 NA NA NA 0.935649299908339 99.8785170793048 a10889 gain_cnaBRCA19 293 MP470 PDGFR 4 44 2.99573227355399 NA 3.47298197348324 3.5369127392885 -0.0639307658052619 3.18846582357849 1.52246518415169 0.0380045519654078 0.0200506354286435 0.0419916110205725 0.94230213113394 NA NA NA 0.970738902935034 99.8785170793048 a10890 PTEN_mut 1020 Lenalidomide TNFA 7 38 1.6094379124341 NA 4.2727969586471 4.25139782234886 0.0213991362982364 0.560815796183924 0.73811353757065 0.0298864469514863 0.0381571568487319 0.0289916594250084 0.942411830762193 NA NA NA 0.931646792480144 99.8785170793048 a10891 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1243 piperlongumine Increases ROS levels 6 41 2.30258509299405 NA 1.73398243128734 1.70677372019913 0.0272087110882147 0.520355636630969 0.893556723358992 0.031633476770194 0.0522886833020141 0.0304498980052813 0.942627247963653 NA NA NA 0.916864444106404 99.8785170793048 a10892 loss_cnaBRCA38 196 Phenformin AAPK1 (AMPK) agonist 3 45 8.29404964010203 NA 7.27576700575027 7.19709615593713 0.0786708498131476 1.53133994693408 1.8374563455688 0.0431022414432168 0.0513738637659495 0.0428150851054882 0.942688760977913 NA NA NA 0.938834965915933 99.8785170793048 a10893 loss_cnaBRCA36_(FAT1,IRF2) 1031 Elesclomol HSP70 8 36 -1.6094379124341 NA -2.93596830184844 -2.98682590806459 0.0508576062161499 1.76947717203873 1.80602795022798 0.0282544188009272 0.0287416006376356 0.0281599220043798 0.942717174780461 NA NA NA 0.94297929020783 99.8785170793048 a10894 gain_cnaBRCA64_(SDHC) 276 CAY10603 HDAC6 8 41 2.99573227355399 NA 1.15224207599223 1.18008563210522 -0.0278435561129915 1.36997979500945 0.918932037854809 0.0278686622392133 0.0203240633288313 0.030299907899599 0.942825681442067 NA NA NA 0.957353592098898 99.8785170793048 a10895 gain_cnaBRCA48 1175 AG-014699 PARP1, PARP2 5 38 1.6094379124341 NA 3.83017035276994 3.86570226641917 -0.0355319136492218 1.12301345729403 1.02516951389391 0.0343262892026081 0.0316397932887093 0.0346595496331731 0.942829008510973 NA NA NA 0.949096736045813 99.8785170793048 a10896 loss_cnaBRCA38 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 40 1.6094379124341 NA 2.50237630648971 2.57221377952369 -0.0698374730339837 0.919021951624672 1.64475760243253 0.0431913793993002 0.0759910825965834 0.0424606476545217 0.942831105771427 NA NA NA 0.913235388643344 99.8785170793048 a10897 ASH1L_mut 171 AKT inhibitor VIII AKT1, AKT2, AKT3 3 44 0.940007258491471 NA 1.93917219715599 1.88521459982283 0.0539575973331563 1.20874940482697 1.26543882155685 0.0427226737493603 0.0446391924725539 0.042639435754605 0.943239680728425 NA NA NA 0.946516398858296 99.8785170793048 a10898 POLR2B_mut 1061 SB590885 BRAF 3 39 1.6094379124341 NA 3.96832696999156 4.01526436767813 -0.0469373976865723 0.379654356720984 1.12246238852458 0.0427741956404401 0.123631921656223 0.0418164547573565 0.943441466158194 NA NA NA 0.874438013719272 99.8785170793048 a10899 gain_cnaBRCA12_(TERT) 1377 Afatinib (rescreen) ERBB2, EGFR 10 37 2.30258509299405 NA 2.8747264988295 2.82380597626573 0.0509205225637723 1.65247129495143 2.08192181222255 0.0254169273434738 0.0308147698052867 0.0244584221486264 0.943463835547588 NA NA NA 0.935953062369873 99.8785170793048 a10900 gain_cnaBRCA13_(FGFR1,WHSC1L1) 54 CGP-082996 CDK4 3 9 1.63315443905142 NA 2.77065901806264 2.82189733037661 -0.0512383123139664 1.54388316443673 0.89502507669007 0.0484682415214533 0.0331879467917251 0.0572479069563648 0.943476572277136 NA NA NA 0.960634012751845 99.8785170793048 a10901 loss_cnaBRCA28_(GPS2) 262 VX-11e ERK 4 45 1.63315443905142 NA 3.82255743520396 3.77274567877228 0.0498117564316751 0.480918927172685 1.37968953877163 0.0371605042414682 0.103576203008931 0.0361035979703258 0.94352254419928 NA NA NA 0.878513142464883 99.8785170793048 a10902 loss_cnaBRCA24 1230 IOX2 EGLN1 3 44 -2.30258509299405 NA 0.275494769696496 0.247687799305608 0.0278069703908882 0.633359940059359 0.660012445418035 0.0422052626198488 0.0439038982924656 0.0421309788685514 0.943925922632967 NA NA NA 0.947385096339477 99.8785170793048 a10903 gain_cnaBRCA14_(RAD21) 1009 ATRA Retinoic acid and retinoid X receptor agonist 20 25 2.30258509299405 NA 4.09222042179978 4.11697123141465 -0.0247508096148659 1.36840305564311 0.977922277303494 0.0212145807235884 0.0180873679818215 0.0253095876730749 0.943952237227988 NA NA NA 0.946069535802287 99.8785170793048 a10904 PIK3CA_mut 1219 PFI-1 BRD2, BRD3, BRD4 16 31 2.30258509299405 NA 3.1580644623068 3.17992188831062 -0.0218574260038245 1.05669731324549 0.979061343168682 0.0217355722162499 0.0206846612836486 0.0223248789836641 0.94402143756064 NA NA NA 0.945570722891139 99.8785170793048 a10905 loss_cnaBRCA23 328 SNX-2112 HSP90 3 45 0.940007258491471 NA 0.498325670455426 0.411834242512991 0.0864914279424351 1.2046628772512 2.08567310263147 0.0420834449987389 0.0717972053225305 0.0414693116736797 0.944041087640666 NA NA NA 0.917073621481912 99.8785170793048 a10906 PIK3CA_mut 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 17 32 1.63315443905142 NA 3.59058367206191 3.56925829957599 0.0213253724859208 1.16560625539763 0.915005593902688 0.0211699831835805 0.018295519938374 0.023306275533206 0.944064901071794 NA NA NA 0.948283691931797 99.8785170793048 a10907 NF1_mut 223 ZSTK474 PI3K 5 44 1.63315443905142 2.32630161961136 0.955818956284193 0.907396939178934 0.0484220171052594 2.02601318116565 1.39384041696762 0.0332032805493249 0.0239001490984379 0.0347400007316506 0.944209701295735 NA NA NA 0.960739559986456 99.8785170793048 a10908 loss_cnaBRCA17 1020 Lenalidomide TNFA 8 37 1.6094379124341 NA 4.23862037208286 4.25820899954388 -0.0195886274610286 0.691140346622392 0.720755258383124 0.0273577418952867 0.0283424742264844 0.0271779182089798 0.944387724101262 NA NA NA 0.94384465227434 99.8785170793048 a10909 loss_cnaBRCA20 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 46 3.68887945411394 NA 3.50666878276767 3.45637969297701 0.0502890897906632 2.2852248641699 1.13224236626083 0.0417679398573314 0.0220061887909357 0.0444154814280091 0.944415762837605 NA NA NA 0.973175288434697 99.8785170793048 a10910 PIK3CA_mut 1494 SN-38 TOP1 16 32 -2.99573227355399 NA -3.27953026476432 -3.31591763250322 0.0363873677388966 1.89582359009872 1.59063331938183 0.0214523341861965 0.0191934354699119 0.0228760250998879 0.944447198796444 NA NA NA 0.947863228878631 99.8785170793048 a10911 loss_cnaBRCA17 1036 PLX4720 BRAF 6 37 2.30258509299405 NA 4.56444373874394 4.60183275069018 -0.0373890119462335 0.464810287123609 1.2822650161521 0.0308375352471072 0.0804392953039148 0.029158568217382 0.944479904320856 NA NA NA 0.896403279572281 99.8785170793048 a10912 gain_cnaBRCA61_(NOTCH2) 308 XL-880 MET 3 46 1.63315443905142 NA 1.78443911241716 1.8518568193225 -0.0674177069053368 0.902106716283165 1.64070315625291 0.0417146351641913 0.0747336270625601 0.0410907400576394 0.944486581701754 NA NA NA 0.914080851256667 99.8785170793048 a10913 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 5 38 0.693147180559945 NA 1.63232279746562 1.68847652483103 -0.0561537273654027 1.61965234807672 1.69219983953306 0.0333205222318284 0.0346702349007694 0.0331838628355487 0.944501283395464 NA NA NA 0.944905484975854 99.8785170793048 a10914 loss_cnaBRCA34 172 Embelin XIAP 5 43 3.46573590279973 NA 2.96418642403926 2.9964198258149 -0.0322334017756365 0.695960610819776 0.997612250876088 0.033056738322084 0.0463149800067975 0.0323105512661153 0.944527631437693 NA NA NA 0.928846989347101 99.8785170793048 a10915 POLR2B_mut 1046 681640 WEE1, CHEK1 3 33 0.693147180559945 NA 2.67541707952367 2.63001104760797 0.0454060319156948 1.13454731744642 1.07359994662 0.0421487534966767 0.0400212765192486 0.0422932509065839 0.944686087244774 NA NA NA 0.952126125880976 99.8785170793048 a10916 NF1_mut 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 5 38 1.6094379124341 NA 2.90138898608206 2.95176417786396 -0.0503751917818938 1.50150959369894 1.51985116567561 0.0331836753408951 0.0335496969138874 0.0331448189925233 0.944728836609608 NA NA NA 0.946515006839043 99.8785170793048 a10917 gain_cnaBRCA58_(CCND1) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 10 39 1.63315443905142 NA 3.55687327653782 3.58172962169503 -0.0248563451572092 1.32696843901971 0.915438113235441 0.0246751931017512 0.0187316777297067 0.0271524036391267 0.944796466394722 NA NA NA 0.956382155740528 99.8785170793048 a10918 loss_cnaBRCA36_(FAT1,IRF2) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 9 38 2.77258872223978 NA 4.9893674182378 5.0160016561301 -0.026634237892301 1.01029610386568 1.03743578507777 0.0257917982166788 0.0263628037269378 0.0256731436059963 0.944841145951865 NA NA NA 0.944734401189017 99.8785170793048 a10919 NF1_mut 1025 SB 216763 GSK3A, GSK3B 4 35 2.30258509299405 NA 4.9152840777456 4.88617587672997 0.0291082010156378 1.02636604122276 0.770238458460555 0.0366560878621761 0.0283604482675203 0.0377911550584156 0.945004723666732 NA NA NA 0.959232001859227 99.8785170793048 a10920 loss_cnaBRCA22_(SYNCRIP,ZNF292) 1059 AZD8055 MTORC1/2 16 27 0.693147180559945 NA 0.144357981940185 0.122177549476888 0.0221804324632965 1.06817395508823 0.985015359363764 0.021826216346281 0.0207648130322222 0.0225178544196744 0.945181954711426 NA NA NA 0.946456749148614 99.8785170793048 a10921 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 87 GW843682X PLK1 3 9 -1.36257783450257 NA -1.84431713637905 -1.93816394229792 0.0938468059188724 2.31992036347075 1.91178057336518 0.0469214670951441 0.0404525980273184 0.0490886910487222 0.945277086124881 NA NA NA 0.953568776606706 99.8785170793048 a10922 gain_cnaBRCA27_(CLTC,PPM1D) 87 GW843682X PLK1 3 9 -1.36257783450257 NA -1.84431713637905 -1.93816394229792 0.0938468059188724 2.31992036347075 1.91178057336518 0.0469214670951441 0.0404525980273184 0.0490886910487222 0.945277086124881 NA NA NA 0.953568776606706 99.8785170793048 a10923 ASH1L_mut 205 BMS-708163 g-secretase 3 45 2.32630161961136 0.940007258491471 4.87013981479694 4.89828883114114 -0.0281490163441918 0.556045807508049 0.689392707253605 0.041145370607849 0.0506235564842098 0.0408316131691203 0.9452864131526 NA NA NA 0.939833857399425 99.8785170793048 a10924 loss_cnaBRCA18 207 AS601245 JNK 16 32 2.07944154167984 NA 2.28434217866136 2.25712998039506 0.0272121982663012 1.06772357173264 1.38912471472228 0.0210437120798801 0.0254861829285485 0.0195894565677938 0.945503645834203 NA NA NA 0.940587965521495 99.8785170793048 a10925 loss_cnaBRCA36_(FAT1,IRF2) 1026 17-AAG HSP90 9 34 0 NA -0.93282666325521 -0.886513117365138 -0.0463135458900726 1.8406833411568 1.79189062544606 0.0257081110579414 0.0251610610334346 0.0258461901816936 0.945657422729087 NA NA NA 0.94727298279973 99.8785170793048 a10926 loss_cnaBRCA20 301 PHA-793887 CDK-pan 3 45 2.32630161961136 NA 2.98560924469452 2.91804728357674 0.0675619611177813 0.186800918347897 1.6908173463909 0.0408448860541611 0.361678955945786 0.0399581665411668 0.945685345927478 NA NA NA 0.806766570216644 99.8785170793048 a10927 PIK3CA_mut 273 CUDC-101 HDAC, EGFR 17 32 1.63315443905142 NA -0.00543567724347185 -0.0379178293844246 0.0324821521409527 2.20379553004176 1.13102633146979 0.0205554798013365 0.0147391859626547 0.0287191829554857 0.945685905491864 NA NA NA 0.955158432053028 99.8785170793048 a10928 loss_cnaBRCA28_(GPS2) 1033 Vismodegib SMO 3 42 2.30258509299405 NA 4.72963127612082 4.7619276620791 -0.0322963859582783 0.5841272073485 0.797331592979172 0.0409491893790233 0.0552899874410571 0.04050558919609 0.945688472252326 NA NA NA 0.934865283508904 99.8785170793048 a10929 loss_cnaBRCA34 235 QL-XII-47 BTK, BMX 5 44 2.32630161961136 NA 1.66413688612207 1.71306807308182 -0.0489311869597511 0.836063719559189 1.56351978872121 0.0322921286816344 0.0585256671411957 0.031295534161273 0.945738204749964 NA NA NA 0.914681660041846 99.8785170793048 a10930 PTEN_mut 344 THZ-2-49 CDK9 9 40 2.99573227355399 NA 1.75470099579386 1.79215414528107 -0.037453149487217 1.65929050890465 1.44628908128961 0.0252260004491992 0.0225717855229227 0.0258960327999029 0.945776657704266 NA NA NA 0.951235205190107 99.8785170793048 a10931 gain_cnaBRCA19 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 4 42 1.63315443905142 NA 1.88416824489861 1.94158799562484 -0.0574197507262233 1.22359032030915 1.62910910346248 0.0357818165288282 0.0469272678715827 0.03524610512837 0.945791827212979 NA NA NA 0.934905549867951 99.8785170793048 a10932 gain_cnaBRCA62 288 KIN001-055 JAK3, MNK1 10 39 2.32630161961136 NA 4.35560250582126 4.33475172906213 0.0208507767591266 0.854645026455865 0.863184188420242 0.0242013135424909 0.0243970023971155 0.0241556518745862 0.945854935675773 NA NA NA 0.946202671317393 99.8785170793048 a10933 loss_cnaBRCA18 1059 AZD8055 MTORC1/2 12 31 0.693147180559945 NA 0.113416271223949 0.13701697716876 -0.0236007059448109 1.51872322534727 0.752107529074676 0.0232237744106879 0.0155398334277889 0.0313794305102185 0.945872697372565 NA NA NA 0.959744546710399 99.8785170793048 a10934 gain_cnaBRCA27_(CLTC,PPM1D) 1010 Gefitinib EGFR 10 35 -0.693147180559945 NA 1.41985613409509 1.39419543770258 0.0256606963925121 1.00567754156689 1.06151447604932 0.024437050454355 0.0255158292115498 0.0241736659946593 0.945980820613753 NA NA NA 0.944889300328055 99.8785170793048 a10935 PIK3CA_mut 1032 Afatinib ERBB2, EGFR 16 29 -0.693147180559945 NA 0.265230910531212 0.304397650320065 -0.0391667397888532 1.92808242973275 1.8013989160759 0.0212104421133059 0.020313830562878 0.0217424022182564 0.946014849079304 NA NA NA 0.947230144747484 99.8785170793048 a10936 gain_cnaBRCA8_(CHD4,WNK1) 1007 Docetaxel Microtubules 3 42 -4.38202663467388 NA -4.52818874291704 -4.5915004349993 0.0633116920822676 0.934150221522552 1.57993346239519 0.0406926169365969 0.0677746369091228 0.0400723787356757 0.946028228676537 NA NA NA 0.921793419853509 99.8785170793048 a10937 loss_cnaBRCA7_(FAS,PTEN) 1192 GSK269962A ROCK1, ROCK2 4 42 1.6094379124341 NA 2.7159101181899 2.66337540191354 0.0525347162763588 1.5090510392116 1.47268074382907 0.0356121930783331 0.0348130811425739 0.0356728479655169 0.946048394226056 NA NA NA 0.950412192267182 99.8785170793048 a10938 ASH1L_mut 226 GSK1070916 AURKB 3 46 0.940007258491471 2.32630161961136 2.47847397471442 2.39908730058935 0.0793866741250744 0.867157560169054 1.99700167078814 0.0404575600470093 0.091548154304966 0.039752933253052 0.94615682042415 NA NA NA 0.898573087967374 99.8785170793048 a10939 loss_cnaBRCA42 166 FTI-277 Farnesyl transferase (FNTA) 3 44 0.0237165266173161 NA 2.27554338917238 2.24226367933029 0.0332797098420876 0.572367623593115 0.831095761570434 0.0405193298075284 0.0581439418833122 0.0400431711734427 0.946162269489851 NA NA NA 0.931719343404044 99.8785170793048 a10940 loss_cnaBRCA18 1038 NU-7441 PRKDC (DNAPK) 12 31 0.693147180559945 NA 2.90871935153031 2.88672785340552 0.0219914981247875 1.1324962742885 0.87772031045672 0.0230812669312963 0.0194186052740914 0.0250552458030102 0.946204313460274 NA NA NA 0.952417432307557 99.8785170793048 a10941 BRCA2_mut 1192 GSK269962A ROCK1, ROCK2 5 41 1.6094379124341 NA 2.62568745811334 2.67309683079418 -0.0474093726808453 1.33917550719709 1.48810731627739 0.0321378185421672 0.0354019114194178 0.0318588398580308 0.946216819713523 NA NA NA 0.943883315066328 99.8785170793048 a10942 gain_cnaBRCA10_(MDM2,NUP107) 292 Masitinib KIT 5 43 2.99573227355399 NA 4.04176864091132 4.00667142098099 0.0350972199303374 1.16460419886924 1.09114946416662 0.0319724858382621 0.0301366077543038 0.0321653642172141 0.946344227288899 NA NA NA 0.951377721676708 99.8785170793048 a10943 gain_cnaBRCA19 288 KIN001-055 JAK3, MNK1 4 45 2.32630161961136 NA 4.36686020006058 4.33653114869763 0.0303290513629415 1.1964296234483 0.833841284318916 0.0352026226770715 0.0253496325805845 0.0363726909824504 0.946493444745244 NA NA NA 0.963293609703878 99.8785170793048 a10944 gain_cnaBRCA15 62 BMS-536924 IGF1R 6 6 1.63315443905142 NA 3.14304396795028 3.18603196082254 -0.042987992872265 1.01800654229648 1.14625498499695 0.0396557585422841 0.0422276194564429 0.0375029931689932 0.946593757091393 NA NA NA 0.946612341956418 99.8785170793048 a10945 gain_cnaBRCA13_(FGFR1,WHSC1L1) 200 LAQ824 HDAC 10 38 0.0237165266173161 NA -2.65757647452307 -2.69154397182233 0.0339674972992636 0.787401009484234 1.53655851139004 0.0238972039930507 0.0431387525417489 0.0221062179197687 0.946683211995055 NA NA NA 0.923858325343012 99.8785170793048 a10946 gain_cnaBRCA15 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 20 22 1.38629436111989 0.693147180559945 3.44489647244081 3.4230055330397 0.0218909394011146 1.05262859877628 1.05382292328093 0.0207840675080464 0.0207964513091926 0.0207728821583803 0.946700565414784 NA NA NA 0.946700737404738 99.8785170793048 a10947 PTEN_mut 1047 Nutlin-3a MDM2 6 37 2.07944154167984 1.38629436111989 4.2327482379113 4.20276018916354 0.0299880487477591 1.34305575180569 0.958985130428776 0.0295843842648196 0.0223282233127264 0.0312706086843609 0.94673253285975 NA NA NA 0.959827298209131 99.8785170793048 a10948 gain_cnaBRCA12_(TERT) 1054 PD-0332991 CDK4, CDK6 9 33 1.38629436111989 0.693147180559945 2.85357132154489 2.8909047610714 -0.037333439526519 1.51107366565863 1.46992374720822 0.0252552385478588 0.0247065648584687 0.0253982151097466 0.946789597911498 NA NA NA 0.948361836821505 99.8785170793048 a10949 BRCA1_mut 1203 QL-XII-61 BTK 3 20 2.30258509299405 NA 4.2809269834322 4.21685364626532 0.0640733371668851 0.754798801057669 1.59493354462835 0.0417453149349033 0.0848879689224489 0.040173045066787 0.946881391277119 NA NA NA 0.913575982351996 99.8785170793048 a10950 loss_cnaBRCA36_(FAT1,IRF2) 262 VX-11e ERK 9 40 1.63315443905142 NA 3.74980510829517 3.7828884827728 -0.0330833744776315 1.11449471248017 1.38225045521943 0.0246806608103942 0.0296846401397533 0.0239344283466918 0.946947062043092 NA NA NA 0.939892225076734 99.8785170793048 a10951 loss_cnaBRCA36_(FAT1,IRF2) 1018 ABT-888 PARP1, PARP2 8 37 1.6094379124341 NA 4.38870881354413 4.40618265223335 -0.0174738386892237 0.406408335985114 0.709680648225391 0.0260906629575876 0.0429957683984704 0.0246221152188922 0.946959390497716 NA NA NA 0.925841679709398 99.8785170793048 a10952 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1023 GW 441756 NTRK1 15 30 0.693147180559945 NA 2.34078073564528 2.36853981851943 -0.0277590828741583 1.10957831960437 1.39951275933382 0.0211551300088258 0.0250176867947962 0.0198348194319943 0.94697268252267 NA NA NA 0.942770776836608 99.8785170793048 a10953 CDH1_mut 1031 Elesclomol HSP70 4 40 -1.6094379124341 NA -2.9203199818164 -2.98330497944618 0.0629849976297763 2.14368584647264 1.7708065426274 0.0349915825933675 0.0293816361821 0.0355685367732623 0.947116204227358 NA NA NA 0.957820911230123 99.8785170793048 a10954 gain_cnaBRCA15 1161 ZG-10 IRAK1 14 12 2.30258509299405 NA 1.99271626022158 1.95522065622858 0.0374956039930052 1.50776003848628 1.31393320600281 0.0263644049474656 0.0248684160847299 0.0285369178750515 0.947123232759682 NA NA NA 0.946542148544378 99.8785170793048 a10955 gain_cnaBRCA47_(EGFR) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 7 41 2.32630161961136 NA 4.97481580406818 4.95570313996164 0.019112664106542 0.571039300600014 0.7185836538409 0.0272608958655385 0.0334699627266627 0.0265976883893516 0.947141857960828 NA NA NA 0.938993970238108 99.8785170793048 a10956 gain_cnaBRCA15 1001 AICAR AAPK1 (AMPK) agonist 21 24 7.60090245954208 NA 7.75321586336809 7.7255922989899 0.0276235643781924 1.43568855266949 1.3526537752098 0.019846069878488 0.0192406384565995 0.0204217552816927 0.947353169505823 NA NA NA 0.947577878827406 99.8785170793048 a10957 BRCA1_mut 1049 PD-173074 FGFR1, FGFR3 4 39 0.693147180559945 NA 2.90134083233602 2.94149969836724 -0.0401588660312191 1.36099670642296 1.1343091670086 0.0348477525677612 0.0295069531334625 0.0354038098247288 0.947402091505885 NA NA NA 0.957684064603127 99.8785170793048 a10958 TP53_mut 1054 PD-0332991 CDK4, CDK6 33 9 1.38629436111989 0.693147180559945 2.89079812533329 2.85396231925129 0.0368358060820042 1.41629766490069 1.70366758379284 0.0249185634267561 0.0260085199565637 0.0216214750062905 0.947497869941283 NA NA NA 0.953602934426668 99.8785170793048 a10959 loss_cnaBRCA36_(FAT1,IRF2) 224 AS605240 PI3Kgamma 9 40 2.99573227355399 2.32630161961136 3.23858666713031 3.27738251781741 -0.0387958506870962 0.846477257719871 1.70549286728073 0.0243639445714877 0.0458321240568227 0.0227475889412268 0.947626850768486 NA NA NA 0.921612442869033 99.8785170793048 a10960 gain_cnaBRCA13_(FGFR1,WHSC1L1) 276 CAY10603 HDAC6 11 38 2.99573227355399 NA 1.193057550595 1.17046880178176 0.022588748813239 1.06821360558916 0.97959436956554 0.0226089151364065 0.0211462845025088 0.0230592881247953 0.947630582117836 NA NA NA 0.950668533386069 99.8785170793048 a10961 PIK3CA_mut 1036 PLX4720 BRAF 15 28 2.30258509299405 NA 4.57996926814461 4.60553339949397 -0.02556413134936 1.03408945936833 1.29531393951749 0.0210845193908512 0.0247213924460421 0.0197358575164279 0.947781492797613 NA NA NA 0.944141955810293 99.8785170793048 a10962 ASH1L_mut 328 SNX-2112 HSP90 3 45 0.940007258491471 NA 0.341850017599448 0.422265952703389 -0.0804159351039411 1.80858222402496 2.06576399459156 0.0391270536998028 0.0444635217772833 0.0389279391617244 0.947966261372436 NA NA NA 0.946906965752165 99.8785170793048 a10963 MLL3_mut 1047 Nutlin-3a MDM2 3 40 2.07944154167984 1.38629436111989 4.1699235168635 4.2097211468982 -0.0397976300347063 1.2381564659347 1.00077717169164 0.0392618164904632 0.0321426500847472 0.0397667244621851 0.948024329215743 NA NA NA 0.96118854555081 99.8785170793048 a10964 loss_cnaBRCA36_(FAT1,IRF2) 346 THZ-2-102-1 CDK7 9 39 0.916290731874155 2.99573227355399 -1.28476334428007 -1.34678709123235 0.0620237469522842 2.82626212397774 2.50499297864828 0.0241924986896691 0.0219455040727046 0.0247600482240684 0.94812271985268 NA NA NA 0.952776315393717 99.8785170793048 a10965 loss_cnaBRCA28_(GPS2) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 4 43 -2.30258509299405 NA -0.17323072802839 -0.137570939220589 -0.035659788807801 0.489945861437964 1.07389417961652 0.0341188327132882 0.072783120778164 0.0332060546417476 0.948248628455235 NA NA NA 0.907510673549816 99.8785170793048 a10966 gain_cnaBRCA13_(FGFR1,WHSC1L1) 63 BMS-509744 ITK 3 9 2.32630161961136 NA 3.55887472190043 3.60859556301128 -0.0497208411108501 1.41900244198698 1.03277367695496 0.0443651328996283 0.0350392921390803 0.0481430174105981 0.948253475810973 NA NA NA 0.959197637091554 99.8785170793048 a10967 ASH1L_mut 1072 BMS-708163 g-secretase 3 43 1.6094379124341 NA 3.64920760768995 3.68669457085749 -0.037486963167539 0.286709287686183 0.983116161173372 0.0389492812493144 0.130749036663822 0.0381307567183082 0.948290154269472 NA NA NA 0.87186265169591 99.8785170793048 a10968 gain_cnaBRCA63 310 YM201636 FYV1 7 42 1.63315443905142 NA 2.43804235837053 2.41077167137092 0.0272706869996115 0.838656632330727 1.04894995131767 0.0266182647856429 0.0325171064632531 0.0259980821442955 0.948290377697514 NA NA NA 0.940523769499717 99.8785170793048 a10969 gain_cnaBRCA9_(KRAS) 1066 AZD6482 PI3Kbeta 4 39 1.6094379124341 NA 2.01217434907586 1.96257361632863 0.0496007327472299 1.41329329679078 1.45351414835985 0.0341930414233888 0.0350958522621315 0.0341246989602402 0.948388844244854 NA NA NA 0.950305724180073 99.8785170793048 a10970 gain_cnaBRCA12_(TERT) 154 CHIR-99021 GSK3B 9 38 0.940007258491471 NA 3.25762708470744 3.27965496375466 -0.0220278790472181 0.82825436311067 0.930273979591333 0.0241276945592627 0.0265955484550521 0.0236789155995688 0.948394720546866 NA NA NA 0.945231902321645 99.8785170793048 a10971 loss_cnaBRCA17 111 Salubrinal GADD34-PP1C 3 10 2.77258872223978 NA 3.19856838113355 3.24843632547267 -0.0498679443391197 0.507258007243831 1.24635406068304 0.0434415779733676 0.0983088361878711 0.0400110577822409 0.948567929702443 NA NA NA 0.92130035658612 99.8785170793048 a10972 loss_cnaBRCA7_(FAS,PTEN) 230 GSK429286A ROCK2 4 45 2.99573227355399 2.32630161961136 5.37743632726284 5.40799845346016 -0.030562126197319 0.718043528512779 0.914933694744376 0.0338207980484128 0.0425630550011636 0.0334036514043324 0.948590698178179 NA NA NA 0.9404670956385 99.8785170793048 a10973 gain_cnaBRCA27_(CLTC,PPM1D) 1052 RO-3306 CDK1 10 33 1.6094379124341 NA 3.54743017625121 3.51908038622858 0.0283497900226326 0.951132048867146 1.27504962398061 0.0234027286832939 0.0298063660628394 0.0222342640548582 0.948622866653051 NA NA NA 0.940305928368114 99.8785170793048 a10974 ARID1A_mut 1495 AZD-2281 PARP1, PARP2 5 40 2.30258509299405 NA 4.02980624742713 3.99480192814635 0.0350043192807847 1.59375708383445 1.08159710010814 0.0307325889492814 0.0219633968286855 0.0323635476438362 0.948641492020187 NA NA NA 0.963968463952122 99.8785170793048 a10975 gain_cnaBRCA15 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 14 12 2.30258509299405 NA 2.70630064180371 2.67432489443787 0.0319757473658409 1.41566483289816 1.01885949806484 0.0255900811525758 0.0225870888523662 0.0313838634537672 0.94867391125753 NA NA NA 0.947369041064337 99.8785170793048 a10976 PTEN_mut 219 AT-7519 CDK9 9 40 2.32630161961136 NA 1.6365723746809 1.67997183232051 -0.0433994576396028 1.81349875058961 1.82790291556272 0.0237745430662466 0.0239313413507965 0.0237427585842229 0.948892026051809 NA NA NA 0.949426959550934 99.8785170793048 a10977 gain_cnaBRCA9_(KRAS) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 39 1.6094379124341 NA 2.6167525231628 2.56227358994271 0.054478933220095 1.43980229783774 1.63011808997463 0.0336923568803692 0.0378377873836639 0.0334202371933329 0.949143510129409 NA NA NA 0.946837753435872 99.8785170793048 a10978 loss_cnaBRCA29_(MAP2K4) 1495 AZD-2281 PARP1, PARP2 6 39 2.30258509299405 NA 3.97093327987645 4.0029617611213 -0.0320284812448555 0.819937883716239 1.17454477856409 0.0281198773532873 0.0390620824832381 0.0272688464751518 0.949169314463203 NA NA NA 0.935441784104159 99.8785170793048 a10979 loss_cnaBRCA22_(SYNCRIP,ZNF292) 306 TG101348 JAK2 18 30 2.32630161961136 NA 3.20954886871757 3.23409296942085 -0.0245441007032783 1.60942228345563 1.06430830761094 0.0189849017062458 0.0152502552969374 0.0230610815754812 0.949503092787631 NA NA NA 0.95451803394351 99.8785170793048 a10980 TP53_mut 238 CAL-101 PI3Kdelta 38 11 2.99573227355399 2.32630161961136 4.72362514586392 4.70286283721275 0.0207623086511717 1.00454905116991 0.727931626874026 0.0217989272925223 0.0206682875534965 0.0285223335333454 0.949504135231859 NA NA NA 0.940136802083911 99.8785170793048 a10981 ARID1A_mut 1019 Bosutinib SRC, ABL, TEC 5 40 0.693147180559945 NA 2.63733176722529 2.66575688357057 -0.0284251163452724 0.883886668207803 0.947354132428423 0.0301871185651341 0.0321592319102495 0.0300047420201865 0.949551780428382 NA NA NA 0.948887383315711 99.8785170793048 a10982 loss_cnaBRCA38 1049 PD-173074 FGFR1, FGFR3 3 40 0.693147180559945 NA 2.97846303715191 2.93471156135526 0.0437514757966517 0.354005203378274 1.17887150013067 0.0379650530174383 0.123589922913932 0.0371130151096216 0.949738617041565 NA NA NA 0.879140247430698 99.8785170793048 a10983 loss_cnaBRCA36_(FAT1,IRF2) 293 MP470 PDGFR 9 39 2.99573227355399 NA 3.49962256226227 3.53896116313504 -0.0393386008727683 1.8220691139902 1.65125818197203 0.0233850605016457 0.0215900706349276 0.0238234101137279 0.949851755706967 NA NA NA 0.953687477281951 99.8785170793048 a10984 loss_cnaBRCA57 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 5 38 -1.38629436111989 0.693147180559945 -2.24597940891084 -2.21716006351783 -0.0288193453930061 0.540569090512304 0.995343414873903 0.0300044826408909 0.0533129731218884 0.0289541729641695 0.95001657224479 NA NA NA 0.923416510543872 99.8785170793048 a10985 loss_cnaBRCA36_(FAT1,IRF2) 1170 CCT018159 HSP90 9 34 2.30258509299405 NA 3.32041159791196 3.34876227234793 -0.0283506744359703 0.777095135392467 1.28321835379049 0.0235995060087762 0.0364828875445887 0.022093414072691 0.950108357563182 NA NA NA 0.934313232172051 99.8785170793048 a10986 loss_cnaBRCA36_(FAT1,IRF2) 163 JQ1 BRD4 9 38 0.940007258491471 NA 0.343570124878647 0.309367259777745 0.0342028651009016 1.89182084509327 1.36104099398628 0.0232754673058577 0.0180793362064975 0.0251299301431962 0.950215006564703 NA NA NA 0.960176574698203 99.8785170793048 a10987 gain_cnaBRCA9_(KRAS) 228 KIN001-102 AKT1 4 45 2.32630161961136 NA 1.98627298753318 1.93991965006428 0.0463533374688996 1.93581179669565 1.37466280404823 0.0327091826038298 0.0239451673701043 0.0337197873779621 0.950278111345499 NA NA NA 0.965344601184756 99.8785170793048 a10988 BRCA2_mut 283 GSK2126458 PI3K, MTOR 6 42 -2.05572501506252 0.0237165266173161 -3.09473768442101 -3.0497322210908 -0.0450054633302028 2.20931543214506 1.56392390525364 0.0273360707102376 0.0203707730799247 0.0287772718218689 0.95032868713052 NA NA NA 0.963188550694116 99.8785170793048 a10989 BRCA2_mut 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 3 23 2.30258509299405 NA 2.73417933372822 2.68598129205747 0.0481980416707488 0.0883868761938432 1.30483416714712 0.03857250048333 0.545307671752587 0.0369380591681842 0.95041668969929 NA NA NA 0.863283508997405 99.8785170793048 a10990 ASH1L_mut 293 MP470 PDGFR 3 45 2.99573227355399 NA 3.47301005061082 3.53549018379543 -0.0624801331846121 0.856766573089728 1.71029344928529 0.0371416311540535 0.0729255028698098 0.0365318204374354 0.950603027185385 NA NA NA 0.917294968759423 99.8785170793048 a10991 loss_cnaBRCA22_(SYNCRIP,ZNF292) 344 THZ-2-49 CDK9 19 30 2.99573227355399 NA 1.76870007974148 1.79577244194331 -0.0270723622018321 1.54203898632515 1.44799690392901 0.0182340220652561 0.0175562112514085 0.0186964227122127 0.95067510143025 NA NA NA 0.951453345441328 99.8785170793048 a10992 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1042 BIRB 0796 p38, JNK2 8 35 2.30258509299405 NA 4.34812333329625 4.37081777662294 -0.0226944433266887 1.09136532908125 0.895219350658281 0.0243597824481161 0.0207945430571757 0.0253507068519026 0.950736648228409 NA NA NA 0.957494575427315 99.8785170793048 a10993 gain_cnaBRCA63 178 BAY 61-3606 SYK 6 42 2.07944154167984 NA 3.13409842094434 3.0902748789055 0.0438235420388473 2.1320829424942 1.54440816347815 0.0270740558913774 0.0205543326506711 0.0283756218564351 0.950804157432756 NA NA NA 0.962905525064646 99.8785170793048 a10994 TP53_mut 1495 AZD-2281 PARP1, PARP2 36 9 2.30258509299405 NA 3.99342551008587 4.01975444443311 -0.0263289343472377 1.05254186900769 1.45818324064499 0.0231158050208536 0.0250146194868807 0.0180559847441339 0.950829375428823 NA NA NA 0.960350302423859 99.8785170793048 a10995 TP53_mut 225 Genentech Cpd 10 AURKA, AURKB 38 11 2.32630161961136 NA 3.02580833960193 2.99130836296517 0.0344999766367673 1.56669425424831 1.82736687600882 0.0212221243543219 0.0220208739153895 0.0188796114725026 0.950838493225414 NA NA NA 0.955432059678685 99.8785170793048 a10996 gain_cnaBRCA9_(KRAS) 1013 Nilotinib ABL 3 37 0.693147180559945 NA 3.23609213468745 3.20021672681514 0.0358754078723105 0.877566503080923 0.971120794943532 0.0371218598260478 0.0408805574806703 0.0369422713004478 0.951015304099546 NA NA NA 0.95134305951472 99.8785170793048 a10997 loss_cnaBRCA38 229 LY317615 PRKCB (PKCbeta) 4 45 2.99573227355399 2.32630161961136 3.31071672427643 3.36283785847046 -0.0521211341940329 1.09880161239287 1.65563888779129 0.0320586767736556 0.0474345264933934 0.0314809796860747 0.951265675290803 NA NA NA 0.934902375727178 99.8785170793048 a10998 gain_cnaBRCA48 1373 Dabrafenib BRAF 5 41 2.30258509299405 NA 4.25730014268615 4.20938047163852 0.0479196710476284 0.729077650253469 1.71298789704668 0.0290775259816361 0.0657264298678869 0.0279743196844797 0.951331349749547 NA NA NA 0.911641155926945 99.8785170793048 a10999 gain_cnaBRCA58_(CCND1) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 9 37 1.38629436111989 NA 2.88592555901689 2.85196473490332 0.0339608241135703 1.00869072892742 1.58058986275943 0.022746814878504 0.0336682227164735 0.0214861710262273 0.951475699646232 NA NA NA 0.937140838787651 99.8785170793048 a11000 PIK3CA_mut 170 Shikonin unknown 16 31 2.77258872223978 NA 0.0184034047410483 -0.00402832715014009 0.0224317318911884 1.55129808538665 0.970407736101631 0.0187585574915075 0.0144599752313866 0.0231157801578358 0.951678081081027 NA NA NA 0.958418481461364 99.8785170793048 a11001 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 9 37 2.30258509299405 NA 1.43144641526143 1.40873049637213 0.0227159188893058 0.800205937575041 1.04272809381982 0.022647875721087 0.0283875910220618 0.0217850837854486 0.951686492510078 NA NA NA 0.943808706894542 99.8785170793048 a11002 gain_cnaBRCA9_(KRAS) 206 Ruxolitinib JAK1, JAK2, TYK2 4 45 1.65632149833295 0.0237165266173161 4.38943600291907 4.36855595894529 0.0208800439737793 0.323275756808219 0.675060625816393 0.031720655317443 0.0645889570561464 0.0309306204143187 0.951778872398351 NA NA NA 0.916424426973291 99.8785170793048 a11003 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 32 VX-680 AURKA, AURKB, AURKC, FLT3, ABL1, JAK2 3 9 0.693147180559945 NA 1.26007904323791 1.1681619745204 0.0919170687175095 3.43925622542476 1.81262073664322 0.0411305413789037 0.0267258566076034 0.0507094875719728 0.952020764642992 NA NA NA 0.968116281140775 99.8785170793048 a11004 gain_cnaBRCA27_(CLTC,PPM1D) 32 VX-680 AURKA, AURKB, AURKC, FLT3, ABL1, JAK2 3 9 0.693147180559945 NA 1.26007904323791 1.1681619745204 0.0919170687175095 3.43925622542476 1.81262073664322 0.0411305413789037 0.0267258566076034 0.0507094875719728 0.952020764642992 NA NA NA 0.968116281140775 99.8785170793048 a11005 loss_cnaBRCA28_(GPS2) 1218 JQ1 BRD2, BRD3, BRD4 4 42 0 NA 2.47841022814996 2.45603631427945 0.0223739138705135 1.20290737922389 0.656857739826736 0.0316192918524739 0.0185998641765328 0.0340620388768125 0.95208954137897 NA NA NA 0.972925402914165 99.8785170793048 a11006 NF1_mut 1495 AZD-2281 PARP1, PARP2 5 40 2.30258509299405 NA 3.96971060541696 4.00231388339762 -0.032603277980654 0.961482581202016 1.15567065893929 0.0286243721319542 0.0339093797621319 0.0282115650583172 0.952160086125666 NA NA NA 0.946808567143702 99.8785170793048 a11007 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1022 AZD7762 CHEK1, CHEK2 6 39 0.693147180559945 NA 0.942264609670806 0.89897931268728 0.0432852969835262 1.01235157581171 1.70092690800024 0.0264609095244512 0.0427571784523767 0.025448064099601 0.952164296423593 NA NA NA 0.932033314220197 99.8785170793048 a11008 gain_cnaBRCA62 1023 GW 441756 NTRK1 8 37 0.693147180559945 NA 2.38465002766416 2.35380284780943 0.0308471798547285 2.26055894647716 1.03100946951189 0.0235083315970227 0.013645819722065 0.0299193952790098 0.952202238162781 NA NA NA 0.970849572872812 99.8785170793048 a11009 gain_cnaBRCA14_(RAD21) 91 KIN001-135 IKKE 6 8 1.6094379124341 NA 3.69556668061891 3.70934211988869 -0.0137754392697818 0.572190286815601 0.252861169044469 0.033051166680122 0.0240749267982963 0.0544782709098334 0.952208301744728 NA NA NA 0.957739248628441 99.8785170793048 a11010 gain_cnaBRCA10_(MDM2,NUP107) 223 ZSTK474 PI3K 5 44 1.63315443905142 2.32630161961136 0.949536428678778 0.908110862770458 0.0414255659083195 1.26007866486757 1.47546259728018 0.0284053691114242 0.0328753807705119 0.0280763239845469 0.952260686174615 NA NA NA 0.947976165394653 99.8785170793048 a11011 loss_cnaBRCA20 158 PF-562271 FAK 3 42 0.940007258491471 NA 2.28965929302414 2.33636384216299 -0.0467045491388416 0.685270801994952 1.32197274037045 0.0359460505931631 0.0681548797977031 0.0353294343465462 0.952315456861528 NA NA NA 0.922683326525565 99.8785170793048 a11012 gain_cnaBRCA12_(TERT) 223 ZSTK474 PI3K 9 40 1.63315443905142 2.32630161961136 0.938742915461235 0.906396846653573 0.0323460688076623 1.24525738260677 1.49834479626763 0.022179586954451 0.0259754081842506 0.0215878674175905 0.952316324507758 NA NA NA 0.947014849964467 99.8785170793048 a11013 gain_cnaBRCA31 1047 Nutlin-3a MDM2 13 30 2.07944154167984 1.38629436111989 4.22102279472898 4.20084400316806 0.0201787915609204 1.03268964455267 1.00567455457618 0.0199069435691755 0.0195400347697504 0.0200649320091669 0.952485253540334 NA NA NA 0.953231516420648 99.8785170793048 a11014 loss_cnaBRCA34 1264 SGC0946 Q8TEK3 (DOT1L) 5 41 -0.693147180559945 NA 1.93530544718397 1.95259271406954 -0.0172872668855684 0.12001085107034 0.640478850159211 0.0282590017643679 0.144047531797238 0.026991159632002 0.952699673299907 NA NA NA 0.879801879815728 99.8785170793048 a11015 PTEN_mut 1373 Dabrafenib BRAF 8 38 2.30258509299405 NA 4.24607498263252 4.20796053130394 0.0381144513285738 1.11560480740821 1.7303954606113 0.0231276840893993 0.0341648324527409 0.0220264397336716 0.952858749158503 NA NA NA 0.938277779130122 99.8785170793048 a11016 NF1_mut 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 5 41 2.30258509299405 NA 1.38802945684306 1.41624143460747 -0.0282119777644096 1.08318771489567 0.994632971278224 0.0281274118443988 0.0260453265638513 0.0283642092903414 0.952919665193204 NA NA NA 0.957981343124958 99.8785170793048 a11017 PIK3CA_mut 1378 Bleomycin (50 uM) DNA damage 16 32 3.91202300542815 NA 3.7897215067342 3.82421566638886 -0.0344941596546673 2.17171085291544 1.75386487189692 0.0181525133065917 0.0158834034504916 0.0196675127071561 0.952981236524926 NA NA NA 0.956438899099301 99.8785170793048 a11018 PIK3CA_mut 140 Vinorelbine Microtubules 16 31 -2.74887219562247 NA -3.61977858426764 -3.58951442228941 -0.0302641619782245 1.97075637953005 1.47861052817851 0.0182428366124719 0.0153566226107772 0.0204679740888269 0.95300496316047 NA NA NA 0.957326118503608 99.8785170793048 a11019 loss_cnaBRCA36_(FAT1,IRF2) 1013 Nilotinib ABL 7 33 0.693147180559945 NA 3.22254398333035 3.19874204281546 0.0238019405148959 0.617075008008788 1.01867833962855 0.0246288089705634 0.0385721998233267 0.0233655115544864 0.953114080540621 NA NA NA 0.936397609611227 99.8785170793048 a11020 gain_cnaBRCA58_(CCND1) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 10 37 2.32630161961136 NA 1.44252948186355 1.41001919343266 0.0325102884308908 1.59820255212983 1.53080424249826 0.0210488081152881 0.0203417823276319 0.0212373911231355 0.953167326318329 NA NA NA 0.954906509387489 99.8785170793048 a11021 loss_cnaBRCA34 1502 Bicalutamide ANDR (androgen receptor) 5 40 2.30258509299405 NA 4.57294288926499 4.55647316340944 0.0164697258555453 0.386471434600696 0.605114327578038 0.0279995515033612 0.0426156356745018 0.0272175440324891 0.953203094607396 NA NA NA 0.935971621713486 99.8785170793048 a11022 gain_cnaBRCA27_(CLTC,PPM1D) 152 CP466722 ATM 9 40 2.77258872223978 NA 2.74911939474978 2.72587179301092 0.0232476017388645 1.04016608638519 1.07503274428754 0.0217434284520819 0.0223498939670828 0.0216250173423988 0.953252898052518 NA NA NA 0.952970883800624 99.8785170793048 a11023 gain_cnaBRCA12_(TERT) 166 FTI-277 Farnesyl transferase (FNTA) 9 38 0.0237165266173161 NA 2.22988285099241 2.24782332629258 -0.0179404753001755 0.625044706876762 0.857896514336177 0.0218429438777321 0.0287027073468406 0.0209121671441427 0.953275356734927 NA NA NA 0.943802715829972 99.8785170793048 a11024 gain_cnaBRCA48 1030 KU-55933 ATM 4 38 2.30258509299405 NA 4.19623856926925 4.22504259565617 -0.0288040263869167 0.829902714848232 0.937964668717105 0.0309622322717676 0.0347077143761172 0.0307090739636422 0.953323521856128 NA NA NA 0.951275561424497 99.8785170793048 a11025 loss_cnaBRCA36_(FAT1,IRF2) 1016 Temsirolimus MTOR 8 36 -1.6094379124341 NA -1.77932799060751 -1.74463272989479 -0.034695260712712 2.12430827995386 1.3552501245507 0.0229639045581507 0.016332497990106 0.0256006327423983 0.95342904596806 NA NA NA 0.965759326148123 99.8785170793048 a11026 gain_cnaBRCA8_(CHD4,WNK1) 1003 Camptothecin TOP1 3 42 -2.30258509299405 NA -2.47682780183065 -2.53302813275788 0.0562003309272239 0.371264702353225 1.63782968692033 0.0350969053589516 0.151375367954464 0.0343139041721117 0.953440557294923 NA NA NA 0.868570989296444 99.8785170793048 a11027 loss_cnaBRCA18 1020 Lenalidomide TNFA 14 31 1.6094379124341 NA 4.24542377780482 4.25892784098449 -0.0135040631796635 0.774374180889468 0.689215577634496 0.0188596298518276 0.0174386795336491 0.0195933806748996 0.953566322054957 NA NA NA 0.955833669765331 99.8785170793048 a11028 gain_cnaBRCA9_(KRAS) 345 KIN001-270 CDK9 4 45 2.99573227355399 NA 5.12709159565139 5.10585324529001 0.021238350361374 0.400673110402757 0.7110646187159 0.0305410187257867 0.0530066775382686 0.0298683829884941 0.953570002101803 NA NA NA 0.929062172219033 99.8785170793048 a11029 loss_cnaBRCA42 167 OSU-03012 PDPK1 (PDK1) 3 45 2.77258872223978 NA 2.2869722212893 2.24537948133731 0.0415927399519895 0.296885456855395 1.21816874554619 0.0348639973498792 0.14009692624401 0.0341436603952111 0.953628554271446 NA NA NA 0.871599598644656 99.8785170793048 a11030 PTEN_mut 1061 SB590885 BRAF 6 36 1.6094379124341 NA 3.98765828874811 4.01595393102592 -0.0282956422778158 0.873892012188952 1.12566027863689 0.0257853656868164 0.0323788773477171 0.0251369288006504 0.953660867218548 NA NA NA 0.945747054318303 99.8785170793048 a11031 CDH1_mut 133 Doxorubicin DNA intercalating 4 44 0.0237165266173161 NA -1.08236047757407 -1.02594357498484 -0.0564169025892312 1.78445864699698 1.8534026892554 0.0305123685042575 0.0316156962696635 0.030439635658399 0.953661796837087 NA NA NA 0.955069628475585 99.8785170793048 a11032 gain_cnaBRCA12_(TERT) 1241 CHIR-99021 GSK3B 10 36 2.30258509299405 NA 4.215395395576 4.23595700829554 -0.0205616127195372 0.728735209710088 1.0411955115242 0.0208667487014033 0.028215478606718 0.0197480804440246 0.95371421676966 NA NA NA 0.943871485945744 99.8785170793048 a11033 gain_cnaBRCA12_(TERT) 1049 PD-173074 FGFR1, FGFR3 9 34 0.693147180559945 NA 2.91781664104809 2.94304417047746 -0.0252275294293689 1.80444933472978 0.927736502941065 0.0218908579733861 0.0139807358088814 0.0271925588239698 0.953716236846582 NA NA NA 0.968527753749833 99.8785170793048 a11034 NF1_mut 186 Bexarotene Retinioic acid X family agonist 5 42 2.07944154167984 NA 3.63273724556603 3.60103263087938 0.0317046146866504 0.85828345304924 1.1734336796378 0.0275949969281686 0.0369395618359096 0.0270186677243119 0.95374412501711 NA NA NA 0.942898078622773 99.8785170793048 a11035 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 224 AS605240 PI3Kgamma 6 43 2.99573227355399 2.32630161961136 3.2348069836876 3.27520322824985 -0.0403962445622548 1.17466830734438 1.63499642128906 0.0253687356755909 0.0343894904712124 0.0247072372980521 0.953826758538389 NA NA NA 0.942258129374204 99.8785170793048 a11036 gain_cnaBRCA8_(CHD4,WNK1) 288 KIN001-055 JAK3, MNK1 4 45 2.32630161961136 NA 4.31497787645975 4.34114291079548 -0.0261650343357314 1.06670790817194 0.845770426756832 0.0303691141764657 0.0245287713115126 0.0309363315481047 0.953831037956694 NA NA NA 0.964633074891367 99.8785170793048 a11037 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1268 XAV 939 TNKS1 (tankyrase-1) 9 38 1.6094379124341 NA 3.67793599604181 3.65753637543954 0.0203996206022685 1.17586787508318 0.889177667546021 0.0215523989195588 0.0173485652891277 0.0229421198336751 0.95389614654125 NA NA NA 0.961980834768321 99.8785170793048 a11038 loss_cnaBRCA42 263 FR-180204 ERK 3 46 2.99573227355399 NA 5.38188796703311 5.35631947126124 0.0255684957718705 0.342400318249025 0.751332484592444 0.0346194782310793 0.0746742757209552 0.0340308668880994 0.953916789734473 NA NA NA 0.916437093375451 99.8785170793048 a11039 NF1_mut 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 4 43 2.77258872223978 NA 5.03955390468227 5.00823614135709 0.0313177633251769 0.942467147371672 1.03882404488533 0.0303266870597922 0.0332295543802402 0.0301473223298695 0.953993541247518 NA NA NA 0.953014284183178 99.8785170793048 a11040 loss_cnaBRCA38 1047 Nutlin-3a MDM2 3 40 2.07944154167984 1.38629436111989 4.17431565935742 4.20939173621116 -0.035076076853743 0.665163380774291 1.02835202664861 0.0346034265340017 0.0527330244983005 0.0341090170921873 0.954183703547328 NA NA NA 0.938662271930021 99.8785170793048 a11041 gain_cnaBRCA10_(MDM2,NUP107) 262 VX-11e ERK 5 44 1.63315443905142 NA 3.80950353407129 3.77309699125482 0.0364065428164744 1.34207178875851 1.34032526287044 0.0271594548157893 0.0271271202639259 0.0271624685626726 0.954352210847125 NA NA NA 0.956404123314854 99.8785170793048 a11042 gain_cnaBRCA63 150 Bicalutamide ANDR (androgen receptor) 6 42 0.0237165266173161 NA 2.77634548388444 2.76062235196246 0.0157231319219853 1.08311123819759 0.547395975009838 0.0250304040433192 0.014516636304273 0.028723506638321 0.954513317421424 NA NA NA 0.973399424632505 99.8785170793048 a11043 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 261 TL-1-85 MAP3K7 (TAK1) 15 34 2.32630161961136 NA 4.03984946869362 4.01816984708201 0.0216796216116082 1.01654595833692 1.29790393869783 0.0177571616926392 0.0213267500931057 0.016703564081452 0.954558965334552 NA NA NA 0.950139842367479 99.8785170793048 a11044 loss_cnaBRCA38 173 FH535 unknown 4 44 3.46573590279973 NA 1.53768908254778 1.5762079781654 -0.0385188956176217 1.11727464453383 1.3009977888449 0.029863919573444 0.0344757627912457 0.0296071952987874 0.954645468288601 NA NA NA 0.951420569962636 99.8785170793048 a11045 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1038 NU-7441 PRKDC (DNAPK) 8 35 0.693147180559945 NA 2.9102293590286 2.88889602290589 0.0213333361227024 0.870217671045644 0.968930323981914 0.0223901232308756 0.0245149424477539 0.0220174099155355 0.954715302554354 NA NA NA 0.95225975072268 99.8785170793048 a11046 loss_cnaBRCA34 1241 CHIR-99021 GSK3B 5 41 2.30258509299405 NA 4.20774184123154 4.23438285483516 -0.0266410136036237 0.759505645409755 1.00517820234062 0.0270363222724613 0.0350767815415655 0.026503771710915 0.95474388895061 NA NA NA 0.945606073189782 99.8785170793048 a11047 loss_cnaBRCA29_(MAP2K4) 288 KIN001-055 JAK3, MNK1 7 42 2.32630161961136 NA 4.32180940409282 4.34187325388062 -0.0200638497878005 1.16329332946689 0.808017804286666 0.0232875855600298 0.0172474553748154 0.0248309501119388 0.954753001876576 NA NA NA 0.966209471717758 99.8785170793048 a11048 gain_cnaBRCA14_(RAD21) 235 QL-XII-47 BTK, BMX 21 28 2.32630161961136 NA 1.69383546473256 1.71875481738667 -0.0249193526541054 1.4286468405357 1.57640260773469 0.0164452713339984 0.017442626089987 0.0158077337171592 0.954812118855793 NA NA NA 0.954171030585377 99.8785170793048 a11049 loss_cnaBRCA20 1261 rTRAIL TR10A (DR4), TR10B (DR5) 3 44 -2.30258509299405 NA -0.173800479303494 -0.138342542288373 -0.0354579370151214 0.157364787247542 1.068667740635 0.0339253161239277 0.225323197363998 0.0331795708496379 0.954913103424675 NA NA NA 0.849617311828577 99.8785170793048 a11050 BRCA2_mut 1166 QL-VIII-58 MTOR, ATR 3 23 2.30258509299405 NA -1.48378236326345 -1.52362420962401 0.0398418463605608 0.739880103737883 1.16766954534963 0.0350049272113592 0.053849057650394 0.0341208234120992 0.954997214434751 NA NA NA 0.939861621509399 99.8785170793048 a11051 gain_cnaBRCA31 1039 SL 0101-1 RSK, AURKB, PIM3 13 30 2.30258509299405 NA 4.66161354868714 4.64328811035892 0.0183254383282181 0.668350838889892 1.07337290433206 0.0188445957428963 0.0274188902921945 0.017072760318672 0.955018044944709 NA NA NA 0.946218999251175 99.8785170793048 a11052 gain_cnaBRCA31 186 Bexarotene Retinioic acid X family agonist 15 32 2.07944154167984 NA 3.61825633391506 3.5979128661262 0.0203434677888614 1.28737780123239 1.0806045909345 0.0177064659604973 0.0158022514986563 0.0188260053302832 0.955126056481161 NA NA NA 0.958127763262564 99.8785170793048 a11053 loss_cnaBRCA18 172 Embelin XIAP 16 32 3.46573590279973 NA 3.00431063268752 2.98743795335115 0.0168726793363683 0.813335320150942 1.0444324778876 0.017303337650622 0.0207450468685375 0.0161548780735868 0.95517832711157 NA NA NA 0.951339937905836 99.8785170793048 a11054 gain_cnaBRCA27_(CLTC,PPM1D) 1047 Nutlin-3a MDM2 10 33 2.07944154167984 1.38629436111989 4.19106523358454 4.21175648759616 -0.0206912540116226 1.15152274488021 0.971368212644133 0.0204124034361343 0.0179686020998006 0.0213011438322648 0.955179981743348 NA NA NA 0.959674061811941 99.8785170793048 a11055 ASH1L_mut 1529 MLN4924 NEDD8-activating enzyme 3 34 0 NA 0.422963786230144 0.364472756419105 0.0584910298110389 1.94147437138066 1.70161624318504 0.0340811989032356 0.030127119200365 0.0343738078696034 0.955196274051469 NA NA NA 0.963808121737067 99.8785170793048 a11056 gain_cnaBRCA61_(NOTCH2) 222 BX-912 PDPK1 (PDK1) 3 46 2.32630161961136 NA 3.83567984354162 3.88691779745643 -0.0512379539148156 1.68902781322376 1.51512086600567 0.033644419897787 0.0303357668320572 0.0338177336636481 0.955213295997904 NA NA NA 0.963402620868146 99.8785170793048 a11057 loss_cnaBRCA17 1058 GDC0941 PI3K (class 1) 6 37 1.38629436111989 0.693147180559945 1.37590923865446 1.34115283941965 0.034756399234801 1.79011961235545 1.334794319096 0.02485648984014 0.0194156854072273 0.0260387677244087 0.955235082859075 NA NA NA 0.965163096169452 99.8785170793048 a11058 ASH1L_mut 1069 EHT 1864 Rac GTPases 3 43 2.30258509299405 NA 3.58869015911736 3.55951924159376 0.0291709175236092 0.988371513139352 0.859255586542986 0.0337024693836205 0.0295141221047074 0.0339490577430769 0.955247777571444 NA NA NA 0.964395161857134 99.8785170793048 a11059 gain_cnaBRCA15 231 FMK RSK 22 27 2.99573227355399 2.32630161961136 5.58390374560627 5.59356936176554 -0.00966561615927652 0.638000214680817 0.563229895551469 0.0161687858123442 0.0151498634904255 0.0171610495742822 0.955345160605248 NA NA NA 0.95594391542089 99.8785170793048 a11060 gain_cnaBRCA19 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 4 41 2.30258509299405 NA 1.39507123789656 1.36242184727561 0.0326493906209506 0.76377501533621 1.13296142165855 0.0293823206272713 0.0427473928386863 0.0288177425963497 0.955528262043001 NA NA NA 0.941561142398446 99.8785170793048 a11061 MLL3_mut 291 KIN001-266 MAP3K8 (COT) 3 46 2.99573227355399 NA 3.7414152733873 3.78106174389054 -0.0396464705032487 1.36178728964654 1.18033709185145 0.0333549643436817 0.0291135559897457 0.0335891083800986 0.955598200205127 NA NA NA 0.964841493850254 99.8785170793048 a11062 loss_cnaBRCA29_(MAP2K4) 1239 YK 4-279 RNA helicase A 6 36 2.30258509299405 NA 1.98600317180706 2.01814449820642 -0.0321413263993529 0.835637407115251 1.35977843562706 0.0246139526127749 0.0384632450937179 0.0236371790853787 0.955763731791451 NA NA NA 0.938980856739441 99.8785170793048 a11063 loss_cnaBRCA7_(FAS,PTEN) 1019 Bosutinib SRC, ABL, TEC 4 41 0.693147180559945 NA 2.63754296550137 2.66504298334009 -0.0275000178387188 0.70330171090429 0.957126844466139 0.0292043557322542 0.0391013094555961 0.0287318425950717 0.95579733526399 NA NA NA 0.945944693237794 99.8785170793048 a11064 loss_cnaBRCA29_(MAP2K4) 253 XMD14-99 EPHB3, CAMK1 7 41 2.32630161961136 NA 4.94820922400524 4.93052253079673 0.0176866932085025 1.20489832895754 0.692815015867577 0.0227061048549569 0.0146789922298297 0.0255287382684025 0.955963277225559 NA NA NA 0.97096110479097 99.8785170793048 a11065 gain_cnaBRCA10_(MDM2,NUP107) 344 THZ-2-49 CDK9 5 44 2.99573227355399 NA 1.82011465817439 1.78131594278445 0.0387987153899436 1.07555140119251 1.51719290980452 0.0261318386008124 0.0360733251306501 0.0255726975384709 0.956077521935566 NA NA NA 0.944302225779211 99.8785170793048 a11066 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1033 Vismodegib SMO 6 39 2.30258509299405 NA 4.74318990759612 4.76232605615661 -0.0191361485604977 0.895086323172882 0.773623945666523 0.0242626182694064 0.0213791095507574 0.0247357242077232 0.956134004755213 NA NA NA 0.962002929182215 99.8785170793048 a11067 PIK3CA_mut 266 Zibotentan, ZD4054 Endothelin A Receptor 17 32 2.99573227355399 NA 5.73666915424226 5.74489231932901 -0.00822316508674614 0.543459015937026 0.469784827751415 0.0165757778679113 0.0151311595641998 0.0175041095433108 0.956189314566491 NA NA NA 0.958267486954694 99.8785170793048 a11068 gain_cnaBRCA64_(SDHC) 157 JNK-9L JNK 8 39 1.63315443905142 NA 0.0747588223467098 0.0519643953602309 0.0227944269864788 1.03583292186298 1.06899316162153 0.0214252911663623 0.0220058915925189 0.0213232673555203 0.95622187116741 NA NA NA 0.95611245591081 99.8785170793048 a11069 gain_cnaBRCA10_(MDM2,NUP107) 154 CHIR-99021 GSK3B 4 43 0.940007258491471 NA 3.25135478186947 3.27767705250154 -0.0263222706320669 0.726222887580602 0.924880900309847 0.028831068078048 0.0362454434887877 0.0284601732214911 0.956260026712001 NA NA NA 0.949394469173965 99.8785170793048 a11070 gain_cnaBRCA63 304 SB52334 ALK5 7 42 2.99573227355399 NA 4.27727339272813 4.30599480700281 -0.0287214142746794 1.18972851232843 1.29584698638012 0.0223898222730554 0.0241411498312909 0.0221642019285866 0.95649550476863 NA NA NA 0.954800317773749 99.8785170793048 a11071 gain_cnaBRCA13_(FGFR1,WHSC1L1) 134 Etoposide TOP2 10 37 2.77258872223978 NA 2.4437944823693 2.4861036467949 -0.0423091644255993 2.19748940111631 2.1702645089256 0.0194459024547143 0.0192534100069409 0.0194949344891349 0.956729956041017 NA NA NA 0.957564156022697 99.8785170793048 a11072 BRCA1_mut 207 AS601245 JNK 4 44 2.07944154167984 NA 2.23245690119459 2.26926833241921 -0.0368114312246224 0.633576715474038 1.32699054307279 0.0284664398906489 0.0581009849724043 0.0277405377278586 0.956765630443728 NA NA NA 0.925037069369059 99.8785170793048 a11073 gain_cnaBRCA61_(NOTCH2) 221 TAK-715 p38a 3 46 2.99573227355399 2.32630161961136 4.45129049509192 4.48416546729586 -0.032874972203941 0.312289404003395 1.0342763135071 0.0324185365761089 0.105270853837819 0.0317854830228744 0.956843489990253 NA NA NA 0.894022942791495 99.8785170793048 a11074 loss_cnaBRCA36_(FAT1,IRF2) 29 AZ628 BRAF 3 11 1.38629436111989 NA 2.54581567052965 2.46979808935686 0.0760175811727897 1.4064947153331 2.22955868845345 0.0359464469531733 0.0540475412698485 0.034095348808925 0.956896473152046 NA NA NA 0.945209771251823 99.8785170793048 a11075 loss_cnaBRCA20 341 EX-527 SIRT1 3 46 2.99573227355399 NA 5.62171374822016 5.64306016209037 -0.0213464138702113 0.253657795704303 0.671766758693753 0.0323725856754834 0.0841543774002338 0.0317765259950035 0.956904599702942 NA NA NA 0.909444190384859 99.8785170793048 a11076 loss_cnaBRCA23 269 NSC-207895 MDM4 3 46 2.99573227355399 NA 4.56761291647322 4.6063117136051 -0.0386987971318815 0.410955705573541 1.21995519983962 0.0323373075401402 0.094167805938775 0.0317214903768343 0.956951515973109 NA NA NA 0.901765099288962 99.8785170793048 a11077 gain_cnaBRCA10_(MDM2,NUP107) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 3 40 0.693147180559945 NA 2.93753676571525 2.9062348381011 0.031301927614158 0.967260661309496 0.963719430895702 0.0324745014655169 0.0323614190737177 0.0324803325642871 0.956999559714223 NA NA NA 0.961199515383945 99.8785170793048 a11078 gain_cnaBRCA15 170 Shikonin unknown 22 25 2.77258872223978 NA 0.0136585976478075 -0.00523651256197336 0.0188951102097808 0.964340241133874 1.36657661677372 0.0158009151799171 0.0195938211471543 0.0138266014344584 0.957132708764111 NA NA NA 0.956197098892783 99.8785170793048 a11079 TP53_mut 111 Salubrinal GADD34-PP1C 9 4 2.77258872223978 NA 3.22526467746941 3.26317157522565 -0.0379068977562405 1.06348656662506 1.34770639133754 0.0330199196201249 0.0356439836156432 0.0281269703845653 0.957164835446449 NA NA NA 0.962317164836008 99.8785170793048 a11080 NF1_mut 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 4 43 2.32630161961136 NA 1.37705123642771 1.42064651232403 -0.0435952758963225 0.777674129683972 1.58517172938683 0.0282256112262225 0.0560585394733892 0.0275019261876352 0.957177650954115 NA NA NA 0.927397991439022 99.8785170793048 a11081 gain_cnaBRCA15 1043 JNK Inhibitor VIII JNK 20 23 2.30258509299405 NA 4.79068495737847 4.80311050621819 -0.0124255488397198 0.932074396008629 0.551754435642873 0.0165168008066297 0.0133310698082997 0.0225200705912627 0.957180019764656 NA NA NA 0.958720615361744 99.8785170793048 a11082 gain_cnaBRCA64_(SDHC) 158 PF-562271 FAK 8 37 0.940007258491471 NA 2.3108208638456 2.33809979295008 -0.0272789291044799 1.40230626613193 1.27831544933012 0.0209949906798101 0.0194529039506648 0.0213397476489664 0.957307075506429 NA NA NA 0.960627931487969 99.8785170793048 a11083 NF1_mut 1047 Nutlin-3a MDM2 4 39 2.07944154167984 1.38629436111989 4.18095881457734 4.20960977354383 -0.028650958966483 1.08108454665818 1.00814990019835 0.0282647343685117 0.0265020520874599 0.0284193441479744 0.957327281621062 NA NA NA 0.962216422450658 99.8785170793048 a11084 gain_cnaBRCA14_(RAD21) 34 Imatinib ABL, KIT, PDGFR 6 8 0.693147180559945 NA 2.76918957534766 2.78355989057442 -0.0143703152267589 0.457862079120766 0.507678084554146 0.0294751271391912 0.0313856855198715 0.0283059593548917 0.957373327689651 NA NA NA 0.956730275773971 99.8785170793048 a11085 gain_cnaBRCA30_(CRNKL1,FOXA2) 304 SB52334 ALK5 5 44 2.99573227355399 NA 4.2727221822591 4.30520647117998 -0.0324842889208874 1.34830564921075 1.27652525052579 0.025323142271928 0.0240926743427223 0.0254474315392565 0.957435428369985 NA NA NA 0.961114300924583 99.8785170793048 a11086 gain_cnaBRCA9_(KRAS) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 4 45 1.63315443905142 NA 3.60244685355449 3.57436445771703 0.028082395837461 0.685189313413983 1.02565054916731 0.0278771419480585 0.0409848713161321 0.0273800817054698 0.957615639972556 NA NA NA 0.943683908718724 99.8785170793048 a11087 POLR2B_mut 153 Midostaurin KIT 3 44 -0.669430653942629 NA 0.568507570843763 0.615162007302697 -0.0466544364589335 2.52274572998093 1.39840313093291 0.0318071588247137 0.0184935151824778 0.0333626516037683 0.957725328941639 NA NA NA 0.97748529398233 99.8785170793048 a11088 loss_cnaBRCA38 262 VX-11e ERK 4 45 1.63315443905142 NA 3.742811821057 3.77983417780757 -0.0370223567505663 0.440804254346363 1.38063642517711 0.0276187051916246 0.083988201986535 0.0268154280702953 0.958008190373506 NA NA NA 0.904722002665979 99.8785170793048 a11089 loss_cnaBRCA29_(MAP2K4) 341 EX-527 SIRT1 7 42 2.99573227355399 NA 5.62957677426239 5.64378264954716 -0.014205875284766 0.832571976528317 0.630076969056073 0.0215436701501034 0.0170626392495242 0.0225462538426822 0.958138030212436 NA NA NA 0.966769796200218 99.8785170793048 a11090 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1061 SB590885 BRAF 8 34 1.6094379124341 NA 3.9935026254185 4.01624324253158 -0.0227406171130857 0.789830012957606 1.15208995632303 0.020722994890877 0.028791786511038 0.0197385776937626 0.958204258484179 NA NA NA 0.947877264882435 99.8785170793048 a11091 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1502 Bicalutamide ANDR (androgen receptor) 6 39 2.30258509299405 NA 4.57004134305207 4.55649725447154 0.01354408858053 0.582948297031983 0.588908879241418 0.0230255926387967 0.0232337733028611 0.022998614994524 0.958368346669777 NA NA NA 0.959353803646313 99.8785170793048 a11092 loss_cnaBRCA29_(MAP2K4) 155 AP-24534 ABL 7 40 -0.669430653942629 NA 1.42443180299786 1.44902215354931 -0.0245903505514422 1.29202439418319 1.11890977767852 0.0215043297313496 0.0190324197144807 0.0219770628892542 0.958372559219131 NA NA NA 0.963450379819794 99.8785170793048 a11093 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1016 Temsirolimus MTOR 5 39 -1.6094379124341 NA -1.71764715397549 -1.75520939567167 0.0375622416961825 1.97062698018485 1.4540464827783 0.02486127500209 0.0190610613139271 0.0258329029649802 0.958507783693045 NA NA NA 0.968866970869933 99.8785170793048 a11094 loss_cnaBRCA18 88 MS-275 HDAC 6 8 1.6094379124341 NA 1.10918904764002 1.16165980379138 -0.0524707561513549 1.66807745912333 1.93605740222626 0.0286854528404303 0.0314558271046544 0.0271018597336108 0.958514168961436 NA NA NA 0.957579942150346 99.8785170793048 a11095 gain_cnaBRCA61_(NOTCH2) 150 Bicalutamide ANDR (androgen receptor) 3 45 0.0237165266173161 NA 2.780926422181 2.76136516487082 0.019561257310178 0.422109799418833 0.635946942532464 0.0311403088296328 0.0463416327626371 0.0307592599349267 0.958576435184778 NA NA NA 0.945653634038454 99.8785170793048 a11096 PTEN_mut 260 NG-25 MAP3K7 (TAK1) 9 40 2.32630161961136 NA 3.18801278003519 3.21291779521936 -0.0249050151841659 1.39874696010441 1.27233782557666 0.0192357397020774 0.0178052327508236 0.0195742158124382 0.95863896998946 NA NA NA 0.96174886578591 99.8785170793048 a11097 ARID1A_mut 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 40 2.30258509299405 NA 3.14800605579763 3.18047459352119 -0.0324685377235596 0.916532761018375 1.34689173109619 0.024731843205483 0.0354253978739214 0.0241062714796939 0.958659165457948 NA NA NA 0.946105483322691 99.8785170793048 a11098 loss_cnaBRCA17 238 CAL-101 PI3Kdelta 11 38 2.99573227355399 2.32630161961136 4.73213886735961 4.71515050555825 0.0169883618013627 0.959830594223174 0.950458035321991 0.0178363009601818 0.0176993335111515 0.017873868356121 0.958673894928719 NA NA NA 0.959317844829456 99.8785170793048 a11099 loss_cnaBRCA20 1072 BMS-708163 g-secretase 3 43 1.6094379124341 NA 3.65644485783008 3.68618964642911 -0.0297447885990234 0.432745622236727 0.980586035057691 0.0309045410315 0.0687350421831696 0.0303336857099677 0.958959495275105 NA NA NA 0.923973400880753 99.8785170793048 a11100 gain_cnaBRCA61_(NOTCH2) 287 KIN001-244 PDPK1 (PDK1) 3 46 2.99573227355399 NA 3.50555446257225 3.47631592746272 0.0292385351095295 0.957620069374279 0.949389998493548 0.0307857769347128 0.0305325003564663 0.0307971804589515 0.959015041042775 NA NA NA 0.963283994657178 99.8785170793048 a11101 loss_cnaBRCA17 271 VNLG/124 HDAC, RAR 11 38 1.63315443905142 NA 4.14022375260096 4.1546869446656 -0.0144631920646363 0.798630885021809 0.824687860285958 0.0176549784794063 0.0181099833926925 0.0175377773350771 0.959093630888187 NA NA NA 0.958749544650189 99.8785170793048 a11102 gain_cnaBRCA10_(MDM2,NUP107) 1031 Elesclomol HSP70 3 41 -1.6094379124341 NA -3.02919950102221 -2.97380196590356 -0.0553975351186486 0.977425520041423 1.83150054119679 0.0307756744562666 0.0566769886633417 0.0302470754840451 0.959206323648212 NA NA NA 0.93549806359937 99.8785170793048 a11103 gain_cnaBRCA12_(TERT) 1058 GDC0941 PI3K (class 1) 9 34 1.38629436111989 0.693147180559945 1.36728454507322 1.34036910543515 0.0269154396380793 1.25567588829215 1.43072643638992 0.0192487960277221 0.0214350214804929 0.0188124290944072 0.959296966596526 NA NA NA 0.956541278394968 99.8785170793048 a11104 PIK3CA_mut 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 10 16 2.30258509299405 NA 2.70752582631348 2.68155309096073 0.0259727353527501 1.56704868193058 1.01238637417286 0.0207852102403785 0.0165743002449369 0.0256549633769718 0.959304649394145 NA NA NA 0.963442085420544 99.8785170793048 a11105 gain_cnaBRCA63 1069 EHT 1864 Rac GTPases 6 40 2.30258509299405 NA 3.57832048017347 3.55888687462107 0.0194336055523969 0.471592989288221 0.903719089506514 0.0224523744814943 0.0412084275928873 0.0215040334746153 0.959330670736419 NA NA NA 0.93678298083965 99.8785170793048 a11106 gain_cnaBRCA8_(CHD4,WNK1) 295 NVP-BHG712 EPHB4 4 45 2.32630161961136 NA 3.91705553740139 3.88401071585479 0.0330448215465964 1.47783856412564 1.21999653067187 0.0266908082951334 0.0223602376800523 0.0270859963252503 0.959417697710468 NA NA NA 0.967808125512023 99.8785170793048 a11107 BRCA1_mut 268 YM155 BIRC5 (Survivin) 4 45 1.63315443905142 NA -3.63494662196989 -3.59207856908853 -0.0428680528813605 1.33122607859025 1.62737423140954 0.0266244751478378 0.0322019329179287 0.026341853062421 0.959518465114854 NA NA NA 0.954762793416691 99.8785170793048 a11108 loss_cnaBRCA17 294 MPS-1-IN-1 MPS1 11 38 2.99573227355399 NA 4.77251047560634 4.75188821613383 0.0206222594725087 1.23776057407925 1.16524454502461 0.0174610065229947 0.0166609438888044 0.0176977953345177 0.95954266155509 NA NA NA 0.961312989561006 99.8785170793048 a11109 loss_cnaBRCA36_(FAT1,IRF2) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 9 38 -2.30258509299405 NA -0.15657482562458 -0.136823680736254 -0.0197511448883257 0.785099895441315 1.09331317423406 0.0188972955471893 0.0251574926999874 0.0180654046377542 0.959570435606516 NA NA NA 0.950943472162566 99.8785170793048 a11110 PTEN_mut 164 JQ12 HDAC 8 39 1.63315443905142 NA 1.60486727111881 1.57234797134631 0.0325192997725041 0.954201816506811 1.75282784714058 0.0196595906172283 0.0340801067551437 0.0185524778292138 0.959826418698476 NA NA NA 0.941729172742662 99.8785170793048 a11111 POLR2B_mut 253 XMD14-99 EPHB3, CAMK1 3 45 2.32630161961136 NA 4.91109238245498 4.93456913740751 -0.0234767549525312 0.767047329150196 0.77948092872165 0.0301391896688332 0.0306066575820567 0.0301184468887945 0.959906969698419 NA NA NA 0.963243385835886 99.8785170793048 a11112 gain_cnaBRCA8_(CHD4,WNK1) 255 CP724714 ERBB2 4 44 2.32630161961136 NA 3.76245846501531 3.80672452341998 -0.0442660584046668 2.0911015033409 1.64879723721198 0.0263301314488241 0.0211687755634741 0.0268474845818629 0.960007299343629 NA NA NA 0.969480440949681 99.8785170793048 a11113 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 205 BMS-708163 g-secretase 7 41 2.32630161961136 0.940007258491471 4.90854651706096 4.89447783478817 0.0140686822727893 0.669195757664329 0.686367660379153 0.0205636705094231 0.0210232687695044 0.0204972977092448 0.960114598866508 NA NA NA 0.96036566283665 99.8785170793048 a11114 gain_cnaBRCA64_(SDHC) 231 FMK RSK 8 41 2.99573227355399 2.32630161961136 5.57952429016207 5.5911234353588 -0.0115991451967314 1.08659351973551 0.461824889511318 0.0194030878443106 0.0106747785497146 0.0251158944876382 0.96017519732706 NA NA NA 0.977101017344297 99.8785170793048 a11115 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1259 BMN-673 PARP1 6 40 2.30258509299405 NA 3.33548431344707 3.30104609955402 0.0344382138930479 1.33866794011044 1.59642516434117 0.0219453971454866 0.0257257329179085 0.0215720815872132 0.960248193698083 NA NA NA 0.955910567671264 99.8785170793048 a11116 loss_cnaBRCA28_(GPS2) 1049 PD-173074 FGFR1, FGFR3 3 40 0.693147180559945 NA 2.96989752385786 2.93535397485232 0.0345435490055417 0.340263275956947 1.17910087022369 0.0299743818370955 0.101520062394016 0.029296517268271 0.96030709006007 NA NA NA 0.902127254653575 99.8785170793048 a11117 CDH1_mut 312 AV-951 VEGFR 4 44 -2.05572501506252 NA 0.616804585542449 0.633682326859978 -0.0168777413175291 0.50765210123118 0.655066251423995 0.0261072276242105 0.0332466688832695 0.0257649379445818 0.960345577513656 NA NA NA 0.953581757097493 99.8785170793048 a11118 loss_cnaBRCA34 300 CX-5461 RNA Pol I 5 44 2.32630161961136 NA 3.87593786556301 3.91650477363971 -0.0405669080767024 1.24070755215878 1.75863692722465 0.0235766650910061 0.0326965915586776 0.0230672445509955 0.960368420636194 NA NA NA 0.949544459296536 99.8785170793048 a11119 loss_cnaBRCA23 341 EX-527 SIRT1 3 46 2.99573227355399 NA 5.6601646263788 5.6405524961235 0.0196121302553021 0.54332813763553 0.664089178957834 0.0297423381388072 0.0360962904307711 0.0295323743809223 0.960402967804406 NA NA NA 0.957004491039297 99.8785170793048 a11120 gain_cnaBRCA8_(CHD4,WNK1) 1373 Dabrafenib BRAF 3 43 2.30258509299405 NA 4.16877577402149 4.21778541229176 -0.0490096382702641 0.939886170633145 1.67428765143796 0.0297384799246669 0.0521442274624056 0.0292719343824654 0.960506662625603 NA NA NA 0.940052200836424 99.8785170793048 a11121 ARID1A_mut 1046 681640 WEE1, CHEK1 4 32 0.693147180559945 NA 2.65909942289573 2.6306318161891 0.0284676067066294 1.20269488006516 1.06440196168588 0.0264245012297524 0.0236698494177402 0.0267451655778051 0.960552202477275 NA NA NA 0.966349103421084 99.8785170793048 a11122 loss_cnaBRCA28_(GPS2) 265 Tubastatin A HDAC6 4 45 2.99573227355399 NA 4.71656218723448 4.68955480941304 0.0270073778214464 1.03627997022072 1.04313484651135 0.0259014221242152 0.0260618545157194 0.0258905911462642 0.960616905760754 NA NA NA 0.96285401246203 99.8785170793048 a11123 loss_cnaBRCA22_(SYNCRIP,ZNF292) 279 BIX02189 MAP2K5 (MEK5) 19 30 2.99573227355399 NA 5.03538051452731 5.02227388022327 0.0131066343040382 1.08003329076975 0.779904906132676 0.014455902091618 0.0121353984326696 0.0168054261500037 0.960885743613599 NA NA NA 0.963724920593503 99.8785170793048 a11124 loss_cnaBRCA29_(MAP2K4) 281 CH5424802 ALK 7 41 1.63315443905142 NA 3.59371103791389 3.57208597036278 0.0216250675511107 0.579414587144483 1.12860167386302 0.0201532926769321 0.0373222698062972 0.0191609387544957 0.960909905021985 NA NA NA 0.939678184736138 99.8785170793048 a11125 BRCA2_mut 206 Ruxolitinib JAK1, JAK2, TYK2 6 43 1.65632149833295 0.0237165266173161 4.35786579736971 4.37198993906968 -0.014124141699968 0.37994257801047 0.683885821876738 0.0214568977129094 0.0371744113911308 0.0206527774785682 0.960940225064485 NA NA NA 0.941213332004788 99.8785170793048 a11126 loss_cnaBRCA7_(FAS,PTEN) 1004 Vinblastine Microtubules 4 41 -2.30258509299405 NA -3.4251784697372 -3.45852444208082 0.0333459723436249 1.23356822770382 1.2980782857571 0.0257760199269137 0.0270321264724007 0.025688722097509 0.960981772346035 NA NA NA 0.961703082399804 99.8785170793048 a11127 ASH1L_mut 1010 Gefitinib EGFR 3 42 -0.693147180559945 NA 1.37111454447581 1.40195376255033 -0.0308392180745254 0.675237704536013 1.06501681932994 0.0293678698046462 0.0456716469879543 0.0289565549715244 0.961033809226189 NA NA NA 0.946830989145545 99.8785170793048 a11128 ASH1L_mut 310 YM201636 FYV1 3 46 1.63315443905142 NA 2.44278895854076 2.41283347457718 0.0299554839635836 1.26572367746462 1.01247801409904 0.0292382574317714 0.0236666853096938 0.029586305624858 0.961073513786405 NA NA NA 0.971356149646503 99.8785170793048 a11129 loss_cnaBRCA22_(SYNCRIP,ZNF292) 64 CMK RSK 3 9 1.38629436111989 NA 2.17310923226707 2.214505557155 -0.041396324887935 0.765677142759763 1.33940177977864 0.0332240809270412 0.0540649871546752 0.0309065774832527 0.961234345486764 NA NA NA 0.949455184692478 99.8785170793048 a11130 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1059 AZD8055 MTORC1/2 4 39 0.693147180559945 NA 0.154076473790257 0.128005529532254 0.0260709442580031 0.758244438234347 1.03388948221455 0.0256538473248417 0.0343832977116351 0.0252163743867092 0.961265695647758 NA NA NA 0.952610053049769 99.8785170793048 a11131 PTEN_mut 190 Bleomycin DNA damage 8 40 4.15888308335967 NA 2.12182612201425 2.06971376319245 0.0521123588217973 2.59246991008216 2.79399639419904 0.018852073865014 0.0201014324675984 0.0186515483448705 0.961388359075698 NA NA NA 0.960111470254759 99.8785170793048 a11132 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 206 Ruxolitinib JAK1, JAK2, TYK2 6 43 1.65632149833295 0.0237165266173161 4.38250627843951 4.36855173240878 0.0139545460307309 0.603589008269663 0.664465427120403 0.0211992409060333 0.0231192845455139 0.0210011619283275 0.961408879185418 NA NA NA 0.95973284018494 99.8785170793048 a11133 gain_cnaBRCA61_(NOTCH2) 231 FMK RSK 3 46 2.99573227355399 2.32630161961136 5.57301404181216 5.59028724012111 -0.0172731983089491 0.0642329140757604 0.610789944889572 0.0288946104881118 0.268915065702546 0.0282800960517974 0.961530661426931 NA NA NA 0.860186673622149 99.8785170793048 a11134 BRCA1_mut 1004 Vinblastine Microtubules 4 41 -2.30258509299405 NA -3.42567211775761 -3.45847628129834 0.0328041635407348 0.785681763657255 1.32394867983684 0.0253571854807194 0.0417524818038735 0.0247775189781356 0.961615268621794 NA NA NA 0.944036360616318 99.8785170793048 a11135 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 9 MG-132 Proteasome 3 11 0 NA 0.370053245784404 0.317972587337433 0.0520806584469705 1.62495152824221 1.63792302384624 0.031838653433624 0.0320505919972324 0.0317967680341121 0.961817622448203 NA NA NA 0.963717707860672 99.8785170793048 a11136 gain_cnaBRCA14_(RAD21) 151 QS11 ARFGAP 21 27 2.32630161961136 NA 3.77219674570525 3.75131345157252 0.0208832941327333 1.3663685758051 1.58185724207236 0.0139968870504451 0.0152837927500113 0.0132017565032445 0.961839751060754 NA NA NA 0.961127834191628 99.8785170793048 a11137 loss_cnaBRCA42 269 NSC-207895 MDM4 3 46 2.99573227355399 NA 4.57177541964802 4.60604024600675 -0.0342648263587284 0.768392819928145 1.21226057245777 0.0286320198736977 0.0445928507790229 0.0282652320278461 0.961879990029444 NA NA NA 0.947859977166046 99.8785170793048 a11138 gain_cnaBRCA48 163 JQ1 BRD4 5 42 0.940007258491471 NA 0.286138213196795 0.319461807844719 -0.0333235946479238 1.66972377386176 1.44849404951696 0.0226766987130668 0.0199575493680925 0.0230056828048665 0.961981227896941 NA NA NA 0.96763910062874 99.8785170793048 a11139 gain_cnaBRCA16 164 JQ12 HDAC 16 31 1.63315443905142 NA 1.56180245311345 1.58618289682714 -0.0243804437136848 1.5738590839358 1.6928297433748 0.0147391884682169 0.0154908682502348 0.0144021829774093 0.96202276073475 NA NA NA 0.961195127867895 99.8785170793048 a11140 loss_cnaBRCA17 35 NVP-TAE684 ALK 4 10 0.693147180559945 NA 1.79874544174166 1.76275228322332 0.0359931585183384 0.781775735424325 1.37597675821917 0.0287002933276966 0.0460402605087281 0.0261582605253608 0.962105999389064 NA NA NA 0.952151139895223 99.8785170793048 a11141 BRCA2_mut 235 QL-XII-47 BTK, BMX 6 43 2.32630161961136 NA 1.73575071994259 1.70421337968732 0.0315373402552708 1.75732514320985 1.48386650909222 0.0208125308414591 0.0179462180787251 0.0212534888158938 0.962112295136612 NA NA NA 0.967912121209862 99.8785170793048 a11142 loss_cnaBRCA42 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 3 43 1.63315443905142 NA 1.8938052726685 1.93958030181005 -0.0457750291415431 0.813781916355758 1.63289881244557 0.0285244905111201 0.0562497497444165 0.028032985750652 0.962117586197368 NA NA NA 0.936404962389552 99.8785170793048 a11143 BRCA1_mut 1143 HG-5-88-01 EGFR, ADCK4 3 23 2.30258509299405 NA 4.50823415784364 4.53744785902298 -0.0292137011793319 0.579782707228076 1.02182235867209 0.0294334596015921 0.0503873275541482 0.0285898042173362 0.962153708124617 NA NA NA 0.944938288940267 99.8785170793048 a11144 ASH1L_mut 1007 Docetaxel Microtubules 3 42 -4.38202663467388 NA -4.54593287027947 -4.59023299733056 0.0443001270510894 1.56341166021049 1.55552727502401 0.028472442270206 0.0283355485816993 0.0284791708653296 0.962220955958701 NA NA NA 0.965985467668837 99.8785170793048 a11145 gain_cnaBRCA12_(TERT) 326 GSK690693 AKT 9 39 2.32630161961136 NA 2.96736081610121 2.93316688921895 0.0341939268822555 1.62289061242197 2.00547639346062 0.0175862575771718 0.0210697668841803 0.0170502764299564 0.962275882304132 NA NA NA 0.957407638344551 99.8785170793048 a11146 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1053 MK-2206 AKT1, AKT2 8 34 1.38629436111989 0.693147180559945 1.36880274988083 1.39977935942462 -0.0309766095437933 1.6401363112755 1.66306236067235 0.0186710327634641 0.0188866067599609 0.0186262465415127 0.962339448055578 NA NA NA 0.962653988303336 99.8785170793048 a11147 loss_cnaBRCA34 1021 Axitinib PDGFR, KIT, VEGFR 5 40 0.693147180559945 NA 2.48593866911396 2.45940350956149 0.0265351595524779 0.81706443010171 1.21093500593995 0.0224901736767599 0.0324762143288684 0.0219129510851665 0.962403241999871 NA NA NA 0.950660795022286 99.8785170793048 a11148 loss_cnaBRCA20 1067 CCT007093 PPM1D 3 43 1.88706964903238 NA 4.05939059199203 4.08746731450493 -0.0280767225128997 0.349427725834171 1.01395491936229 0.0282621290983123 0.0803505859355425 0.0276903065183194 0.962465752323292 NA NA NA 0.916377120721145 99.8785170793048 a11149 gain_cnaBRCA16 221 TAK-715 p38a 16 33 2.99573227355399 2.32630161961136 4.49197093706577 4.47739236326766 0.0145785737981132 1.20156261673472 0.913052047018532 0.014376053018683 0.0121330121252698 0.0159668595516739 0.962561007876071 NA NA NA 0.966142748352229 99.8785170793048 a11150 gain_cnaBRCA48 1262 UNC1215 LMBL3 5 41 0 NA 2.76943712493045 2.75606703971345 0.0133700852170042 0.347234057788705 0.618235689086454 0.0223322389258131 0.0385045329428487 0.0216261944320309 0.962611463488089 NA NA NA 0.943605445408179 99.8785170793048 a11151 gain_cnaBRCA27_(CLTC,PPM1D) 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 7 19 2.30258509299405 NA 2.67251111231297 2.69855420696398 -0.0260430946510097 1.18315961468545 1.27096088905864 0.0208413271104648 0.0220114803850312 0.0204908702346451 0.962793871248796 NA NA NA 0.961929448938864 99.8785170793048 a11152 loss_cnaBRCA17 1494 SN-38 TOP1 10 38 -2.99573227355399 NA -3.28141690360933 -3.30967577474313 0.0282588711338021 1.48689096140695 1.74337316628204 0.0166596519322219 0.0190053419297556 0.0162093071525631 0.962816130409381 NA NA NA 0.959556287494149 99.8785170793048 a11153 ASH1L_mut 287 KIN001-244 PDPK1 (PDK1) 3 46 2.99573227355399 NA 3.45323803456593 3.47972786841966 -0.0264898338537316 1.49068354031052 0.918338966495808 0.0278914782738213 0.0177702598421484 0.0288453771648298 0.962865185134103 NA NA NA 0.978387982468121 99.8785170793048 a11154 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 15 30 2.30258509299405 NA 1.3762705008791 1.35985077255665 0.0164197283224448 1.08278850613043 1.12466509489653 0.0147765183909655 0.015164298687584 0.0145996602872746 0.962946797744894 NA NA NA 0.96256913269111 99.8785170793048 a11155 POLR2B_mut 184 BMS-754807 IGF1R 3 45 0.940007258491471 NA 1.67100814033766 1.62392634230269 0.0470817980349698 2.27754532734209 1.65973058954292 0.0278377790627969 0.020672167297726 0.028367132793483 0.962966083938468 NA NA NA 0.974934353635139 99.8785170793048 a11156 gain_cnaBRCA47_(EGFR) 310 YM201636 FYV1 7 42 1.63315443905142 NA 2.39794374520106 2.41745477356584 -0.0195110283647812 0.606388825056792 1.07213190072663 0.0190438273434207 0.0321757716477607 0.0181983470052124 0.962991695420176 NA NA NA 0.945992136873048 99.8785170793048 a11157 loss_cnaBRCA38 204 Tipifarnib Farnesyl-transferase (FNTA) 4 44 2.77258872223978 NA 1.58592655529247 1.62307197952031 -0.0371454242278397 0.617655307945138 1.56936798293955 0.024349561985566 0.0601394074494687 0.0236690340516973 0.963013258869461 NA NA NA 0.926475340961797 99.8785170793048 a11158 gain_cnaBRCA15 197 Bryostatin 1 PRKC 22 26 -4.8283137373023 NA -2.7996894136268 -2.81282389263683 0.013134479010021 1.04787815368089 0.906768548174124 0.013488854414414 0.0125343571329198 0.0144849300700478 0.963062109727563 NA NA NA 0.963530288597736 99.8785170793048 a11159 gain_cnaBRCA58_(CCND1) 197 Bryostatin 1 PRKC 9 39 -4.8283137373023 NA -2.79318647020782 -2.80994641221735 0.0167599420095339 0.677430490968589 1.02525293812587 0.0172121340371295 0.0247404600663465 0.016347128973042 0.963077812863867 NA NA NA 0.952804270813429 99.8785170793048 a11160 gain_cnaBRCA58_(CCND1) 1371 PLX4720 (rescreen) BRAF 9 38 2.30258509299405 NA 4.7205693482054 4.70396844799283 0.0166009002125689 0.566378941963279 1.02975155329405 0.0172244909797415 0.0293105886935415 0.0161212674644332 0.963146535216145 NA NA NA 0.948076957914158 99.8785170793048 a11161 gain_cnaBRCA30_(CRNKL1,FOXA2) 185 OSI-906 IGF1R 5 43 0.940007258491471 NA 2.91573050424591 2.89090379728862 0.0248267069572887 1.47982784237393 1.0981444920359 0.0218461356987524 0.0167767535157751 0.022607869125912 0.963322889041707 NA NA NA 0.972537529976133 99.8785170793048 a11162 POLR2B_mut 155 AP-24534 ABL 3 44 -0.669430653942629 NA 1.41584535303835 1.4473721069055 -0.0315267538671498 1.41371509764119 1.12937518113172 0.0275700436921211 0.0223006417062057 0.0279152175413999 0.96335243907513 NA NA NA 0.973021590816864 99.8785170793048 a11163 loss_cnaBRCA17 292 Masitinib KIT 10 38 2.99573227355399 NA 3.99611906125783 4.01406641300423 -0.0179473517464053 0.867598847091276 1.1467831605866 0.0163490467768501 0.0206862328212812 0.0156501702878379 0.96350888807656 NA NA NA 0.957410156585892 99.8785170793048 a11164 gain_cnaBRCA19 1170 CCT018159 HSP90 3 40 2.30258509299405 NA 3.31215495672127 3.34512891927183 -0.0329739625505687 1.60475537802916 1.17694355347349 0.0274473741606756 0.0205476566721745 0.028016604919797 0.963650911793535 NA NA NA 0.9751191975331 99.8785170793048 a11165 NF1_mut 1268 XAV 939 TNKS1 (tankyrase-1) 5 42 1.6094379124341 NA 3.64311601083038 3.66362443278397 -0.0205084219535929 0.61295934907136 0.972965801512361 0.0216670398903419 0.0334580457654548 0.0210782557020144 0.963672740532772 NA NA NA 0.949596674129426 99.8785170793048 a11166 loss_cnaBRCA38 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 44 2.99573227355399 NA 3.81095206418363 3.85016533456207 -0.0392132703784407 1.67386168948279 1.42674138604761 0.0272574424540008 0.0234268282886368 0.0274844977246158 0.963767668140835 NA NA NA 0.971707368418863 99.8785170793048 a11167 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1199 Tamoxifen ER 8 39 1.6094379124341 NA 3.88327009682545 3.86627794033803 0.0169921564874151 0.519223410040535 1.02117138238422 0.0176913757367924 0.0327260985518519 0.0166398674899624 0.963845381672505 NA NA NA 0.945575588275199 99.8785170793048 a11168 PTEN_mut 186 Bexarotene Retinioic acid X family agonist 8 39 2.07944154167984 NA 3.62125394831748 3.60094936251857 0.0203045857989022 1.05575988767144 1.16529603659283 0.0176724023971247 0.0192322004614945 0.0174244013206035 0.963884128752372 NA NA NA 0.962080661437478 99.8785170793048 a11169 loss_cnaBRCA20 266 Zibotentan, ZD4054 Endothelin A Receptor 3 46 2.99573227355399 NA 5.75465515788043 5.74121661667403 0.0134385412064031 0.413637989028696 0.499449561199867 0.027088346198289 0.0324886532737466 0.0269067033998761 0.963933714903105 NA NA NA 0.961270164129633 99.8785170793048 a11170 PIK3CA_mut 190 Bleomycin DNA damage 17 31 4.15888308335967 NA 2.05393132056166 2.09181700175045 -0.0378856811887927 3.2128433423347 2.49226181294574 0.0137054106338067 0.0117919478642435 0.0152013247532824 0.963974982884359 NA NA NA 0.966685371216004 99.8785170793048 a11171 PIK3CA_mut 333 T0901317 LXR 16 32 2.32630161961136 NA 4.72829704924685 4.73900578442113 -0.0107087351742852 0.93231817512343 0.67807892501732 0.013902764521613 0.0114861379516359 0.015792756240008 0.963980056565333 NA NA NA 0.96775871313606 99.8785170793048 a11172 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 154 CHIR-99021 GSK3B 9 38 0.940007258491471 NA 3.28785468495928 3.27249579527396 0.0153588896853214 0.57353157403565 0.970908002566207 0.0168225745293359 0.0267795015664939 0.015819098869024 0.964005863923945 NA NA NA 0.951158665709083 99.8785170793048 a11173 NF1_mut 1114 Cetuximab EGFR 5 40 4.18661983833127 NA 6.26565434522644 6.28470139387141 -0.0190470486449668 0.532554547678932 0.913311432723849 0.021526194114317 0.0357654417335854 0.0208549328985854 0.964013566859895 NA NA NA 0.947295207984906 99.8785170793048 a11174 gain_cnaBRCA10_(MDM2,NUP107) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 3 42 0.693147180559945 NA 0.662175497575003 0.622954166982898 0.039221330592105 2.15500833572184 1.40371893173035 0.0270989781884138 0.0182000830075525 0.027941014191322 0.964042045196401 NA NA NA 0.977899302753009 99.8785170793048 a11175 loss_cnaBRCA20 167 OSU-03012 PDPK1 (PDK1) 3 45 2.77258872223978 NA 2.21780280189801 2.24999077596339 -0.0321879740653803 0.663693128439846 1.21159549630775 0.0269803027747174 0.0484982783248715 0.0265666009517789 0.964106017454155 NA NA NA 0.944244246447436 99.8785170793048 a11176 gain_cnaBRCA8_(CHD4,WNK1) 229 LY317615 PRKCB (PKCbeta) 4 45 2.99573227355399 2.32630161961136 3.32342084129593 3.36170860362428 -0.0382877623283555 1.21073048936363 1.65033915133657 0.0235496084282918 0.0316236872406508 0.0231999357812891 0.964190233765432 NA NA NA 0.956043273959567 99.8785170793048 a11177 gain_cnaBRCA9_(KRAS) 1069 EHT 1864 Rac GTPases 4 42 2.30258509299405 NA 3.57996067167102 3.55965607569523 0.0203045959757966 0.964202044080741 0.857890595523713 0.0234584970766839 0.0210584452713485 0.0236680482123729 0.964445068728813 NA NA NA 0.969831786672055 99.8785170793048 a11178 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1219 PFI-1 BRD2, BRD3, BRD4 8 39 2.30258509299405 NA 3.15799507375398 3.17545254729503 -0.0174574735410542 0.637282458194716 1.05961869648173 0.0173595734486539 0.0273936200762649 0.0164752411400615 0.964522996145883 NA NA NA 0.951403402462279 99.8785170793048 a11179 gain_cnaBRCA12_(TERT) 194 AUY922 HSP90 9 38 -1.36257783450257 NA -2.37045061903937 -2.39926465644347 0.0288140374040937 1.59978760319102 1.76995935557266 0.0165510144338912 0.0180111643237013 0.0162794910026457 0.964586505108852 NA NA NA 0.962773653587594 99.8785170793048 a11180 gain_cnaBRCA63 268 YM155 BIRC5 (Survivin) 7 42 1.63315443905142 NA -3.57043475687451 -3.59976854282719 0.0293337859526805 1.57454866279468 1.61524836559391 0.0182184987162493 0.018629964665948 0.0181605421045542 0.964594463734875 NA NA NA 0.964818342339429 99.8785170793048 a11181 gain_cnaBRCA13_(FGFR1,WHSC1L1) 29 AZ628 BRAF 4 10 1.38629436111989 NA 2.44605823851142 2.50209930404688 -0.0560410655354651 1.16560046205584 2.34744657780494 0.0264990009781595 0.0480791380578402 0.0238732016589141 0.965010250346823 NA NA NA 0.953715653848115 99.8785170793048 a11182 loss_cnaBRCA29_(MAP2K4) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 37 -1.38629436111989 0.693147180559945 -0.333924659883248 -0.297955886236088 -0.0359687736471602 3.05906629551813 1.48708027455459 0.0210273402202852 0.011758088963243 0.024187513117228 0.965019413076482 NA NA NA 0.980519310390516 99.8785170793048 a11183 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 15 30 -0.669430653942629 NA -3.46342177559108 -3.49757634754076 0.0341545719496823 2.4187649706312 2.46599075409623 0.0139365753558681 0.0141206658622848 0.0138502433121246 0.965051579465146 NA NA NA 0.964923414231363 99.8785170793048 a11184 gain_cnaBRCA63 1008 Methotrexate Dihydrofolate reductase (DHFR) 6 39 -1.6094379124341 NA 0.700984089739222 0.679829456711499 0.0211546330277236 1.84674097858178 0.957354622167848 0.0192592069157527 0.0114551164852417 0.0220969665136423 0.965173281383559 NA NA NA 0.979047622091521 99.8785170793048 a11185 loss_cnaBRCA36_(FAT1,IRF2) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 8 37 0.693147180559945 NA 0.645784399647319 0.621198008346708 0.0245863913006116 1.46698643871991 1.44348737492319 0.0169873088727503 0.0167597945363869 0.0170326334180234 0.965450725185695 NA NA NA 0.966453105544125 99.8785170793048 a11186 loss_cnaBRCA20 275 I-BET BRD2, BRD3, BRD4 3 46 2.99573227355399 NA 4.07224810503498 4.03676886069897 0.0354792443360097 1.83072698145828 1.34517223449299 0.0259096271916351 0.0193798664111829 0.0263752428322921 0.965502066083414 NA NA NA 0.976499191508483 99.8785170793048 a11187 loss_cnaBRCA23 266 Zibotentan, ZD4054 Endothelin A Receptor 3 46 2.99573227355399 NA 5.73002494191728 5.74282293510641 -0.0127979931891327 0.475697566009575 0.496988880762087 0.0257971274991588 0.0269036339548457 0.0257510654353234 0.965651760480158 NA NA NA 0.967706858044218 99.8785170793048 a11188 gain_cnaBRCA47_(EGFR) 1038 NU-7441 PRKDC (DNAPK) 6 37 0.693147180559945 NA 2.90849283623399 2.89033077450084 0.0181620617331473 0.907458326928872 0.958947514446203 0.0190614310121105 0.0200142102333376 0.0189395785061667 0.965663906875769 NA NA NA 0.965289550259824 99.8785170793048 a11189 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1010 Gefitinib EGFR 15 30 -0.693147180559945 NA 1.39033466656798 1.40467938873405 -0.014344722166072 1.06784541310554 1.04143596887892 0.0136602440205949 0.013433332193987 0.013773983801917 0.965744083641831 NA NA NA 0.966146666182971 99.8785170793048 a11190 gain_cnaBRCA64_(SDHC) 178 BAY 61-3606 SYK 8 40 2.07944154167984 NA 3.07320182522743 3.10026302094694 -0.0270611957195057 1.9332945373066 1.5555010254686 0.0167179667496885 0.0139974510853408 0.0173970928186006 0.965756354054993 NA NA NA 0.971105515750914 99.8785170793048 a11191 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1133 JNJ-26854165 MDM2 8 35 2.30258509299405 NA 2.98092001090108 2.96604909969256 0.0148709112085279 0.684815532193871 0.914732147617839 0.0169037166270603 0.0217152072484214 0.016257121002312 0.965803533113546 NA NA NA 0.959478872630223 99.8785170793048 a11192 gain_cnaBRCA58_(CCND1) 176 IPA-3 PAK1, PAK2, PAK3 8 39 3.46573590279973 NA 4.47573481481435 4.50116860593993 -0.0254337911255789 1.39721127049922 1.54285096449563 0.016720524626704 0.0182032536256964 0.0164849306322295 0.965828150937551 NA NA NA 0.964110659868551 99.8785170793048 a11193 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 206 Ruxolitinib JAK1, JAK2, TYK2 6 43 1.65632149833295 0.0237165266173161 4.381102684268 4.36874758275829 0.0123551015097103 0.275206774545677 0.68983653930542 0.0187693206179148 0.0448938858067962 0.0179101871323754 0.965829335475039 NA NA NA 0.937008229315533 99.8785170793048 a11194 gain_cnaBRCA62 1013 Nilotinib ABL 8 32 0.693147180559945 NA 3.21600240213278 3.19963362747376 0.0163687746590178 1.55759183401405 0.772724087562642 0.0169370468622332 0.0105090270130872 0.0211832074636742 0.966047285638862 NA NA NA 0.977701602356926 99.8785170793048 a11195 gain_cnaBRCA12_(TERT) 283 GSK2126458 PI3K, MTOR 9 39 -2.05572501506252 0.0237165266173161 -3.07648913762191 -3.05048146548058 -0.0260076721413269 1.37830973716526 1.69746976132472 0.0157965566244377 0.0188692508222544 0.015321434722366 0.966112432899608 NA NA NA 0.96182050012692 99.8785170793048 a11196 gain_cnaBRCA10_(MDM2,NUP107) 1059 AZD8055 MTORC1/2 3 40 0.693147180559945 NA 0.154414147446238 0.128631977614506 0.0257821698317319 0.352978603525316 1.03892783075882 0.0253695098833657 0.073041735601639 0.0248161316584435 0.966400911299 NA NA NA 0.925136753380255 99.8785170793048 a11197 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 281 CH5424802 ALK 6 42 1.63315443905142 NA 3.55792978071799 3.57771246109436 -0.0197826803763665 0.859657254227418 1.09622062100726 0.0184361669991658 0.0230122880707212 0.018046258205022 0.966488159189263 NA NA NA 0.960820958376643 99.8785170793048 a11198 gain_cnaBRCA10_(MDM2,NUP107) 257 NPK76-II-72-1 PLK3 5 44 2.32630161961136 NA 3.45040905737777 3.48220475612422 -0.0317956987464472 1.79364727527485 1.57686588894066 0.019916354373307 0.0177268402682879 0.0201638572877035 0.966517207530612 NA NA NA 0.971235379202433 99.8785170793048 a11199 loss_cnaBRCA34 309 Y-39983 ROCK 5 44 2.99573227355399 NA 4.91548128239703 4.93719679598565 -0.0217155135886253 0.47416921310489 1.1318207829321 0.0198971300402981 0.0457969707616206 0.0191863534546247 0.966549507356162 NA NA NA 0.937916524424929 99.8785170793048 a11200 gain_cnaBRCA47_(EGFR) 133 Doxorubicin DNA intercalating 7 41 0.0237165266173161 NA -1.05782741271762 -1.02600408099039 -0.0318233317272345 1.8118174537925 1.85453339188216 0.0172109393649815 0.0175643145840227 0.0171597512703382 0.966613269818693 NA NA NA 0.966872750506544 99.8785170793048 a11201 gain_cnaBRCA62 291 KIN001-266 MAP3K8 (COT) 10 39 2.99573227355399 NA 3.79269261481277 3.77502974079485 0.0176628740179239 1.46564779951628 1.1129804225988 0.0148597315996882 0.0120512404301724 0.0158698874295392 0.966738219975883 NA NA NA 0.972219788552586 99.8785170793048 a11202 gain_cnaBRCA10_(MDM2,NUP107) 299 OSI-027 MTORC1/2 5 43 2.99573227355399 NA 1.23363314368405 1.27307844967072 -0.0394453059866708 1.94851265555586 2.00474627656931 0.0197234501541737 0.0202438028176 0.0196759592212203 0.966884402089022 NA NA NA 0.96757075616648 99.8785170793048 a11203 loss_cnaBRCA34 301 PHA-793887 CDK-pan 5 43 2.32630161961136 NA 2.95131915555576 2.91889208644786 0.0324270691078987 0.458256293799221 1.72535646470339 0.0196032968136578 0.0707618630593347 0.0187944171371412 0.967086020493521 NA NA NA 0.923413093435922 99.8785170793048 a11204 gain_cnaBRCA8_(CHD4,WNK1) 166 FTI-277 Farnesyl transferase (FNTA) 3 44 0.0237165266173161 NA 2.2632784183177 2.24309992734311 0.0201784909745903 0.964415833780176 0.814090270874853 0.0245672947975997 0.0209230191664291 0.0247865521754802 0.967341406141293 NA NA NA 0.974722613050091 99.8785170793048 a11205 loss_cnaBRCA22_(SYNCRIP,ZNF292) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 18 30 2.07944154167984 NA 3.20533046201216 3.21968724409873 -0.014356782086566 1.3476982797177 1.05171738593357 0.0122722434311194 0.0106528162146005 0.0136507984736051 0.967344609380911 NA NA NA 0.969408112997263 99.8785170793048 a11206 gain_cnaBRCA62 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 8 38 1.38629436111989 NA 2.83893096698872 2.86275203912276 -0.0238210721340404 2.72034837490158 1.11839295106092 0.015954878250235 0.00875662556818746 0.0212993761373794 0.967468840615962 NA NA NA 0.981217375521038 99.8785170793048 a11207 gain_cnaBRCA13_(FGFR1,WHSC1L1) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 11 37 0.246860077931526 2.32630161961136 -0.283023467538862 -0.259579234662557 -0.0234442328763052 1.33345158608397 1.7470400797745 0.014073120932101 0.017581615351447 0.013419401848715 0.967489565305156 NA NA NA 0.962598592566687 99.8785170793048 a11208 gain_cnaBRCA62 52 GNF-2 ABL [T315I] 4 8 0.246860077931526 NA 2.47690508507596 2.49180415234063 -0.0148990672646647 0.362595713645231 0.65827733130482 0.0254481233431624 0.0410900258993193 0.0226334199221659 0.967670183856469 NA NA NA 0.960744648942972 99.8785170793048 a11209 loss_cnaBRCA38 1230 IOX2 EGLN1 3 44 -2.30258509299405 NA 0.264457789897828 0.248440320655518 0.01601746924231 0.148012567476108 0.673267486565279 0.0243103214280163 0.108216954245426 0.0237906471973334 0.967682820149027 NA NA NA 0.906162208956423 99.8785170793048 a11210 gain_cnaBRCA16 294 MPS-1-IN-1 MPS1 16 33 2.99573227355399 NA 4.74666647227906 4.76129405722091 -0.0146275849418522 1.31954707287786 1.11021080411506 0.0123851501679743 0.0110853074077534 0.0131755022448297 0.967742687099838 NA NA NA 0.969777347974411 99.8785170793048 a11211 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1371 PLX4720 (rescreen) BRAF 8 39 2.30258509299405 NA 4.71975565951508 4.70456102260143 0.0151946369136517 0.496682952034643 1.02693029493878 0.0157653141226194 0.0305922255865789 0.0147961716472271 0.967779190623908 NA NA NA 0.95022067490276 99.8785170793048 a11212 gain_cnaBRCA19 1053 MK-2206 AKT1, AKT2 3 39 1.38629436111989 0.693147180559945 1.35642902029379 1.39675982457955 -0.0403308042857595 1.6290223808409 1.66065306410621 0.0243090520182707 0.0247576735348111 0.0242861107822459 0.967838211223615 NA NA NA 0.970352999922077 99.8785170793048 a11213 loss_cnaBRCA28_(GPS2) 287 KIN001-244 PDPK1 (PDK1) 4 45 2.99573227355399 NA 3.49651861453592 3.47646936873019 0.0200492458057293 0.210051154322275 0.980062620565154 0.0211099779584559 0.095449348376198 0.0204571069082993 0.96789777356125 NA NA NA 0.91235681634856 99.8785170793048 a11214 BRCA2_mut 1091 BMS-536924 IGF1R 5 42 1.38629436111989 NA 3.04213380841131 3.02106036333533 0.0210734450759857 1.15529253950601 1.09769869496688 0.019106611652825 0.0182407869482101 0.0191978410583985 0.967963044821015 NA NA NA 0.970612535182711 99.8785170793048 a11215 PIK3CA_mut 231 FMK RSK 17 32 2.99573227355399 2.32630161961136 5.5939581436671 5.58671771027084 0.00724043339626146 0.77850408897094 0.478549832289141 0.0121117056902244 0.00930044363136509 0.0151299465755257 0.967980355757982 NA NA NA 0.972391143229672 99.8785170793048 a11216 gain_cnaBRCA27_(CLTC,PPM1D) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 9 40 1.63315443905142 NA 3.58888031684137 3.5739066289978 0.0149736878435656 1.01520349842469 1.00576282956821 0.0148640506067082 0.0147494446845392 0.0148878914624376 0.968033096837802 NA NA NA 0.968725051366059 99.8785170793048 a11217 gain_cnaBRCA61_(NOTCH2) 228 KIN001-102 AKT1 3 46 2.32630161961136 NA 1.91184894708367 1.94578107308205 -0.033932125998386 1.42799263129914 1.41668729839787 0.0239435783171028 0.0237621156122604 0.0239517401170744 0.968118306864292 NA NA NA 0.971419118033712 99.8785170793048 a11218 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 253 XMD14-99 EPHB3, CAMK1 9 39 2.32630161961136 NA 4.94249801248871 4.93093349277703 0.0115645197116772 0.624540720528076 0.807707432898987 0.0148462460495266 0.0185168385848386 0.0143177086660826 0.968149932279266 NA NA NA 0.962991925985368 99.8785170793048 a11219 gain_cnaBRCA12_(TERT) 221 TAK-715 p38a 9 40 2.99573227355399 2.32630161961136 4.49441049976675 4.47939471207461 0.0150157876921373 0.960112929465966 1.02481566893797 0.0148070962238245 0.0156396057498042 0.0146521839461124 0.968155516710401 NA NA NA 0.967274201578628 99.8785170793048 a11220 gain_cnaBRCA9_(KRAS) 329 QL-XI-92 DDR1 4 44 2.32630161961136 NA 4.27162770598662 4.25167213384775 0.0199555721388753 0.669196672453356 0.970574006721076 0.0209216052408676 0.0298201903271811 0.0205605878590258 0.968217212192791 NA NA NA 0.95889741866159 99.8785170793048 a11221 loss_cnaBRCA60 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 3 46 1.63315443905142 NA 3.55409053767995 3.57812861735749 -0.0240380796775423 0.850994789541904 1.01376675705933 0.0238620680468703 0.028247035085235 0.0237116471911848 0.968226781239159 NA NA NA 0.96629719938276 99.8785170793048 a11222 gain_cnaBRCA19 163 JQ1 BRD4 4 43 0.940007258491471 NA 0.287898466230902 0.318523096059036 -0.0306246298281342 1.03080256768334 1.49594143820977 0.0208398897576749 0.0297095009153509 0.0204718106243407 0.968375720438086 NA NA NA 0.959112055631542 99.8785170793048 a11223 gain_cnaBRCA48 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 38 1.38629436111989 0.693147180559945 3.4137033254293 3.43550625984138 -0.0218029344120829 1.4233179803738 1.01741203124074 0.0206997426431194 0.0153183861320693 0.0214297980981157 0.968784301080041 NA NA NA 0.977890886813548 99.8785170793048 a11224 loss_cnaBRCA28_(GPS2) 272 AR-42 HDAC 4 45 1.63315443905142 NA 0.170999297406905 0.139388115677422 0.0316111817294829 1.10324141826534 1.5667983463268 0.0205083566754284 0.0286530048692207 0.0201756542592683 0.968812178958353 NA NA NA 0.960350572816803 99.8785170793048 a11225 ARID1A_mut 1371 PLX4720 (rescreen) BRAF 5 42 2.30258509299405 NA 4.6911953285342 4.70904639321203 -0.0178510646778314 0.538600717573996 0.995610673555001 0.0185214873724864 0.0331434104994093 0.0179297642662779 0.968943629866404 NA NA NA 0.951750784814231 99.8785170793048 a11226 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1047 Nutlin-3a MDM2 8 35 2.07944154167984 1.38629436111989 4.19433425703255 4.20982692486452 -0.0154926678319702 0.791157051421864 1.05367782450989 0.0152835647468261 0.0195822912835408 0.014703420221619 0.969079332023418 NA NA NA 0.963426716920411 99.8785170793048 a11227 gain_cnaBRCA16 265 Tubastatin A HDAC6 16 33 2.99573227355399 NA 4.70008316088809 4.68772377570652 0.0123593851815667 1.18419467603663 0.969304519315573 0.0118531468657331 0.0104369538486123 0.0127507763920193 0.969127567853494 NA NA NA 0.971353927029778 99.8785170793048 a11228 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 260 NG-25 MAP3K7 (TAK1) 6 43 2.32630161961136 NA 3.22758406476078 3.20565866140759 0.0219254033531961 1.7163325644699 1.23500415573316 0.0169341767704314 0.0127745658429361 0.0177533032997611 0.969168514035719 NA NA NA 0.976914975475745 99.8785170793048 a11229 loss_cnaBRCA22_(SYNCRIP,ZNF292) 269 NSC-207895 MDM4 19 30 2.99573227355399 NA 4.6122816722815 4.59866086006353 0.0136208122179777 1.14437669844572 1.22812087001676 0.0113815851629373 0.0119023851468466 0.0110907749803095 0.969199276533022 NA NA NA 0.968724594668897 99.8785170793048 a11230 TP53_mut 301 PHA-793887 CDK-pan 37 11 2.32630161961136 NA 2.92730978691909 2.90531757991187 0.0219922070072198 1.64053029764678 1.70235964549261 0.0132950257491257 0.0134055476078473 0.0129186609101368 0.969286105353871 NA NA NA 0.970214989254614 99.8785170793048 a11231 PTEN_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 8 38 1.38629436111989 NA 2.84004436401332 2.86251763974916 -0.0224732757358344 1.16687173534678 1.54702028438303 0.015052119506408 0.0192594224841307 0.0145268138774256 0.969308550788446 NA NA NA 0.963598159999845 99.8785170793048 a11232 POLR2B_mut 208 SB-715992 KIF11 3 46 -2.05572501506252 NA -1.2027697790298 -1.24232077299338 0.0395509939635765 1.1059217287606 1.74300159580179 0.0229853613358617 0.035762923301906 0.0226913125374294 0.969393545924504 NA NA NA 0.958163028531145 99.8785170793048 a11233 BRCA2_mut 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 6 42 0.246860077931526 2.32630161961136 -0.240438146315057 -0.268453832084565 0.028015685769508 1.971594460436 1.62467942806639 0.016817240398632 0.0142096594059777 0.0172438237879646 0.969429359534659 NA NA NA 0.974565838134144 99.8785170793048 a11234 CDH1_mut 1058 GDC0941 PI3K (class 1) 4 39 1.38629436111989 0.693147180559945 1.37166444632334 1.3433705821836 0.0282938641397392 1.93487618027107 1.34687813990254 0.0202343034543018 0.0146230877346246 0.0210069963284032 0.969443866915898 NA NA NA 0.97886486242981 99.8785170793048 a11235 gain_cnaBRCA16 279 BIX02189 MAP2K5 (MEK5) 16 33 2.99573227355399 NA 5.03450687356284 5.02388897593065 0.0106178976321853 1.10810619371959 0.794868031619774 0.0117108426748304 0.0095820217343467 0.0133580634895434 0.969498022503398 NA NA NA 0.972945850674037 99.8785170793048 a11236 loss_cnaBRCA57 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 5 41 1.63315443905142 NA 1.96254404131554 1.93343045339658 0.0291135879189535 1.37960683541978 1.62557973513611 0.0181418250791632 0.0211028150712916 0.0179096646505105 0.96962312367011 NA NA NA 0.966746641390626 99.8785170793048 a11237 loss_cnaBRCA57 1038 NU-7441 PRKDC (DNAPK) 5 38 0.693147180559945 NA 2.87752900835243 2.89488291137297 -0.0173539030205392 0.597275686376275 0.983591247677686 0.0182131619077107 0.0290550970286885 0.0176434093547627 0.969646313897349 NA NA NA 0.957023864252553 99.8785170793048 a11238 ARID1A_mut 1259 BMN-673 PARP1 5 41 2.30258509299405 NA 3.3308366740388 3.30245284128413 0.0283838327546659 3.21213855899807 1.29504612953476 0.0180870883297199 0.00883642851431646 0.0219172368515265 0.969714729888592 NA NA NA 0.985292397057201 99.8785170793048 a11239 loss_cnaBRCA29_(MAP2K4) 1020 Lenalidomide TNFA 6 39 1.6094379124341 NA 4.26510426758086 4.25313000908465 0.0119742584962088 0.594868030178862 0.730496163588208 0.0167227367752191 0.0201292688272531 0.0163919526112103 0.96975757212784 NA NA NA 0.965722371597713 99.8785170793048 a11240 POLR2B_mut 1049 PD-173074 FGFR1, FGFR3 3 40 0.693147180559945 NA 2.96223250330924 2.93592885139346 0.0263036519157729 0.429709690155741 1.17761745745237 0.0228241046297333 0.0612126105563028 0.0223363298066909 0.969770250503405 NA NA NA 0.935838300159892 99.8785170793048 a11241 MACF1_mut 1248 FK866 NAMPT 3 41 0 NA -0.708801613682348 -0.64645496231858 -0.0623466513637676 2.08170336107045 2.76507725379526 0.022784118990913 0.0299498249989411 0.0225478876867518 0.969793100621787 NA NA NA 0.964631307274347 99.8785170793048 a11242 gain_cnaBRCA31 176 IPA-3 PAK1, PAK2, PAK3 16 31 3.46573590279973 NA 4.48519347245766 4.50285027712418 -0.017656804666518 1.75367776079894 1.39032849635889 0.0116077706343102 0.0100684430522024 0.0126997358629699 0.970086788571118 NA NA NA 0.972361370949213 99.8785170793048 a11243 gain_cnaBRCA10_(MDM2,NUP107) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 39 -1.38629436111989 0.693147180559945 -0.26644754782212 -0.304990985812439 0.0385434379903192 1.18265772201268 1.7339218309213 0.0225323384653199 0.0325905266358256 0.0222290516809743 0.97018768954434 NA NA NA 0.961905860625181 99.8785170793048 a11244 gain_cnaBRCA47_(EGFR) 345 KIN001-270 CDK9 7 42 2.99573227355399 NA 5.11671450691614 5.10606573505341 0.0106487718627379 0.509061446894335 0.718648788609265 0.0153127407928389 0.0209184410402784 0.014817769168366 0.970238506197345 NA NA NA 0.962656692876469 99.8785170793048 a11245 loss_cnaBRCA28_(GPS2) 295 NVP-BHG712 EPHB4 4 45 2.32630161961136 NA 3.90891976174701 3.88473389591296 0.0241858658340499 0.569461324603514 1.27091817079574 0.019535041615672 0.0424714810103904 0.0190302305764554 0.970291611562022 NA NA NA 0.945861297084621 99.8785170793048 a11246 gain_cnaBRCA8_(CHD4,WNK1) 1059 AZD8055 MTORC1/2 3 40 0.693147180559945 NA 0.151624550515445 0.128841197384315 0.0227833531311302 0.376666206698988 1.03850619820552 0.0224185835529701 0.0604868520879482 0.0219385817537714 0.970307089857834 NA NA NA 0.936707925142392 99.8785170793048 a11247 gain_cnaBRCA64_(SDHC) 1043 JNK Inhibitor VIII JNK 7 36 2.30258509299405 NA 4.80706431704592 4.79543862697962 0.0116256900662925 1.17474170056022 0.653009892161946 0.0154532932929582 0.0098963798260915 0.0178032372952313 0.970339701499991 NA NA NA 0.980448189199406 99.8785170793048 a11248 loss_cnaBRCA17 205 BMS-708163 g-secretase 10 38 2.32630161961136 0.940007258491471 4.88936261628632 4.89841554428628 -0.00905292799996538 0.755524632534654 0.665646155834164 0.0132321644422795 0.0119823068767386 0.0136002107435302 0.970462106639408 NA NA NA 0.972983374575578 99.8785170793048 a11249 gain_cnaBRCA12_(TERT) 1025 SB 216763 GSK3A, GSK3B 7 32 2.30258509299405 NA 4.89927514589239 4.88694893672764 0.0123262091647538 0.469088989266203 0.84267759457844 0.0155217289530283 0.0262769100251867 0.0146274319431978 0.970526280872971 NA NA NA 0.958211977479753 99.8785170793048 a11250 loss_cnaBRCA34 1043 JNK Inhibitor VIII JNK 5 38 2.30258509299405 NA 4.7856463576102 4.7988686579615 -0.0132223003513001 0.462297796401412 0.777209459433902 0.0175755587812509 0.0286012619013638 0.0170125314235507 0.970708426202046 NA NA NA 0.957897191808302 99.8785170793048 a11251 gain_cnaBRCA13_(FGFR1,WHSC1L1) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 11 38 3.68887945411394 NA 3.44768193642436 3.46286765590993 -0.0151857194855713 0.728936296160266 1.30306244583788 0.0126121237454988 0.0208327113981886 0.0116538693399354 0.970771388452736 NA NA NA 0.960611435965712 99.8785170793048 a11252 loss_cnaBRCA60 207 AS601245 JNK 3 45 2.07944154167984 NA 2.2927202555041 2.26443274366025 0.0282875118438457 1.04026069954915 1.30350541019526 0.0218744694864726 0.0271927141495448 0.0217011081216827 0.970895226166081 NA NA NA 0.967663663253799 99.8785170793048 a11253 BRCA2_mut 303 PIK-93 PI4K, PI3K 6 43 2.99573227355399 NA 2.81160040658296 2.78872628707475 0.0228741195082112 1.98086043376096 1.35245203530662 0.0159683268883581 0.0115475674703549 0.0169130726347905 0.970926176561728 NA NA NA 0.979073285498275 99.8785170793048 a11254 MLL3_mut 1170 CCT018159 HSP90 3 40 2.30258509299405 NA 3.31833916253187 3.34466510383604 -0.0263259413041648 2.08620820889552 1.13758290120877 0.0219133882643368 0.0126190383068726 0.0231419980699353 0.970975900016244 NA NA NA 0.984640775043378 99.8785170793048 a11255 POLR2B_mut 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 40 1.6094379124341 NA 2.5343816534199 2.56981337850393 -0.0354317250840244 1.37915147643918 1.62826845181963 0.0219119173312482 0.0256909597599135 0.0217603706836109 0.970977847363629 NA NA NA 0.96944696662731 99.8785170793048 a11256 gain_cnaBRCA47_(EGFR) 272 AR-42 HDAC 7 42 1.63315443905142 NA 0.161687710820297 0.138682105223084 0.0230056055972134 0.860125798005364 1.6171846383383 0.0149252920356967 0.026746791749025 0.0142257136580597 0.970991195749925 NA NA NA 0.956004533794686 99.8785170793048 a11257 NF1_mut 1005 Cisplatin DNA crosslinker 4 41 1.79175946922805 2.30258509299405 3.69088263168647 3.66805437303978 0.0228282586466966 0.882052051607907 1.21228782457186 0.0191476879215184 0.0258808520484506 0.0188307250011017 0.971009989430637 NA NA NA 0.964241633805068 99.8785170793048 a11258 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 277 ABT-869 VEGFR and PDGFR family 14 34 0.0237165266173161 NA 2.69498192579995 2.68947085115255 0.00551107464740497 0.410195689675745 0.50357858065594 0.01150449416287 0.0134352329537188 0.0109438225911564 0.97125692163478 NA NA NA 0.968765480454333 99.8950425973452 a11259 gain_cnaBRCA47_(EGFR) 1164 XMD8-92 MAP2K5 (ERK5) 3 23 2.30258509299405 NA 3.8585387464133 3.88787380070313 -0.029335054289827 0.664024977430134 1.36528242143785 0.0222043731510636 0.0441776368162499 0.0214864366736171 0.971444142105447 NA NA NA 0.953548638899198 99.9038305363474 a11260 loss_cnaBRCA18 224 AS605240 PI3Kgamma 16 33 2.99573227355399 2.32630161961136 3.25860558676551 3.275905797837 -0.0173002110714959 0.927038917238632 1.82250288489072 0.0108642425568673 0.0186617959071535 0.00949255620658911 0.971702079411152 NA NA NA 0.965065416484553 99.9038305363474 a11261 CDH1_mut 256 JW-7-24-1 LCK 4 44 2.32630161961136 NA 1.81755817615506 1.83938830613828 -0.0218301299832155 0.370326008481311 1.20889662266577 0.0186163619518892 0.0589484116245031 0.0180578964105941 0.971717583746983 NA NA NA 0.934558493803399 99.9038305363474 a11262 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 8 39 -2.30258509299405 NA -0.152594648577451 -0.138146566922545 -0.014448081654906 0.754047834866589 1.09038546448415 0.0138232814304511 0.0191606964264571 0.0132504349383833 0.971746439527862 NA NA NA 0.964487258521511 99.9038305363474 a11263 gain_cnaBRCA12_(TERT) 226 GSK1070916 AURKB 9 40 0.940007258491471 2.32630161961136 2.383029272946 2.40865435736848 -0.0256250844224848 1.03510079271086 2.10253866940526 0.0130587580668795 0.0247561248169605 0.0121876875775765 0.971913822413356 NA NA NA 0.957767816038649 99.9038305363474 a11264 gain_cnaBRCA13_(FGFR1,WHSC1L1) 45 Z-LLNle-CHO g-secretase 3 9 0.940007258491471 NA 1.0032042724384 0.965406110799121 0.037798161639281 2.25244277266007 1.36006467438183 0.0239318981494574 0.0167809642482692 0.0277914442976476 0.972070291749467 NA NA NA 0.980138658864528 99.9038305363474 a11265 loss_cnaBRCA33 1241 CHIR-99021 GSK3B 5 41 2.30258509299405 NA 4.24611836102005 4.22970279144632 0.0164155695737351 0.758077443444268 1.00531040584247 0.0166587669999902 0.0216542118693734 0.0163288567176211 0.972105279439204 NA NA NA 0.966410013839648 99.9038305363474 a11266 gain_cnaBRCA10_(MDM2,NUP107) 1239 YK 4-279 RNA helicase A 3 39 2.30258509299405 NA 2.03901252500148 2.01159444592997 0.0274180790715093 0.428024178016267 1.33616859476455 0.0209963760447233 0.0640573137680724 0.0205199247901353 0.972219022249365 NA NA NA 0.935904464748817 99.9038305363474 a11267 loss_cnaBRCA20 1262 UNC1215 LMBL3 3 43 0 NA 2.74588345911924 2.75833218315223 -0.0124487240329931 0.351414998927587 0.60796846925124 0.0207930378795397 0.0354245665978484 0.0204759369319345 0.97238043538116 NA NA NA 0.959098068245402 99.9038305363474 a11268 POLR2B_mut 281 CH5424802 ALK 3 45 1.63315443905142 NA 3.55438255345072 3.57663009755375 -0.0222475441030334 0.0937998167200439 1.09697729698245 0.0207331294450467 0.237181104195904 0.0202807698611737 0.972413178037024 NA NA NA 0.897843661765275 99.9038305363474 a11269 gain_cnaBRCA48 175 PAC-1 CASP3 agonist 5 43 0.940007258491471 NA 2.419503008181 2.39927468337731 0.0202283248036967 1.28866085860409 1.22636536394415 0.0164203286761447 0.0156971670774641 0.0164945336833713 0.972427820356621 NA NA NA 0.974688677416314 99.9038305363474 a11270 loss_cnaBRCA20 1494 SN-38 TOP1 3 45 -2.99573227355399 NA -3.27107995653571 -3.30596908014945 0.034889123613735 0.479962539327526 1.73136653091617 0.020568206302611 0.0726913472510126 0.0201512059929177 0.972632530095224 NA NA NA 0.929269456739903 99.9038305363474 a11271 ARID1A_mut 1239 YK 4-279 RNA helicase A 5 37 2.30258509299405 NA 1.99464731495306 2.01610768625698 -0.0214603713039219 1.73745339902567 1.24871784485733 0.016434040044647 0.0123516241160519 0.0171859250608962 0.972657179557035 NA NA NA 0.97982172162314 99.9038305363474 a11272 gain_cnaBRCA19 178 BAY 61-3606 SYK 4 44 2.07944154167984 NA 3.06906666924039 3.09817883551671 -0.0291121662763199 1.57202250686474 1.62190785408627 0.0179848906217853 0.0185189246013923 0.0179493342997101 0.972676535646714 NA NA NA 0.973657168532121 99.9038305363474 a11273 MACF1_mut 1006 Cytarabine DNA synthesis 3 42 0.693147180559945 NA 1.23791877229332 1.20643431068688 0.031484461606442 0.951231482044863 1.56388490089929 0.0204338327541257 0.0330986328782557 0.0201322115127126 0.972882004313141 NA NA NA 0.961611576159877 99.9038305363474 a11274 CDH1_mut 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 4 43 2.77258872223978 NA 4.99412884121645 5.01246172865624 -0.0183328874397928 0.660403811560813 1.05427948072016 0.017752291821075 0.0277601175506005 0.0173890204400733 0.973059111781503 NA NA NA 0.962294076563805 99.9038305363474 a11275 BRCA1_mut 176 IPA-3 PAK1, PAK2, PAK3 4 43 3.46573590279973 NA 4.47219027344783 4.49913239666002 -0.0269421232121827 1.48847511975015 1.52342927934922 0.0177119836170136 0.0181004860979504 0.0176851814372977 0.97312025958207 NA NA NA 0.97425790450809 99.9038305363474 a11276 gain_cnaBRCA15 135 Gemcitabine DNA replication 21 26 0.0237165266173161 NA -0.290499526437869 -0.262885586243673 -0.0276139401941965 3.1314719598027 2.47266243369437 0.00991603869441842 0.00881819813450806 0.0111676951200083 0.97318803726173 NA NA NA 0.973884650452902 99.9038305363474 a11277 gain_cnaBRCA8_(CHD4,WNK1) 1008 Methotrexate Dihydrofolate reductase (DHFR) 3 42 -1.6094379124341 NA 0.703361475683679 0.681170688646018 0.0221907870376614 0.639789283170805 1.11598811082627 0.0202023383147997 0.0346845244541821 0.0198844296120964 0.973189103071876 NA NA NA 0.960046657689933 99.9038305363474 a11278 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 167 OSU-03012 PDPK1 (PDK1) 6 42 2.77258872223978 NA 2.26327277436027 2.24579420661631 0.0174785677439555 0.642814648187745 1.24358484847332 0.0146505751145558 0.0271906805378999 0.0140549860875299 0.97336633421871 NA NA NA 0.958055760086795 99.9038305363474 a11279 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1043 JNK Inhibitor VIII JNK 15 28 2.30258509299405 NA 4.79210237087491 4.80013232955229 -0.00802995867737799 0.825568343383953 0.711366826556509 0.0106736780339195 0.00972658259213731 0.0112880702017669 0.973550698981084 NA NA NA 0.974831332224019 99.9038305363474 a11280 PIK3CA_mut 265 Tubastatin A HDAC6 17 32 2.99573227355399 NA 4.68494826509867 4.69537795830773 -0.0104296932090593 1.21972321586065 0.938379493164071 0.0100024518475325 0.0085508688146925 0.0111145792134608 0.973554247123199 NA NA NA 0.975699967511908 99.9038305363474 a11281 gain_cnaBRCA64_(SDHC) 1006 Cytarabine DNA synthesis 9 36 0.693147180559945 NA 1.1933292951036 1.21233426971657 -0.0190049746129652 1.90382770764162 1.44507590956281 0.0123344697690461 0.00998250762749311 0.0131515406818421 0.973750506425853 NA NA NA 0.978191969908809 99.9038305363474 a11282 loss_cnaBRCA33 303 PIK-93 PI4K, PI3K 6 43 2.99573227355399 NA 2.77342628613416 2.79405290853272 -0.0206266223985616 1.03445114661633 1.47270743968285 0.0143993201533799 0.0199396776406803 0.0140059198743531 0.973781776332099 NA NA NA 0.966640998011606 99.9038305363474 a11283 NF1_mut 1010 Gefitinib EGFR 4 41 -0.693147180559945 NA 1.41638026374176 1.39828977086767 0.0180904928740897 1.36110116920216 1.02298908643563 0.0172271229958102 0.0132910714379107 0.0176839549062267 0.973916633637884 NA NA NA 0.98082457102683 99.9038305363474 a11284 loss_cnaBRCA24 203 BMS-345541 IKBKB 3 46 2.77258872223978 NA 3.55100049807804 3.53111464417824 0.0198858538998059 0.515088027258135 1.0323046155988 0.0195789517678855 0.038606709625266 0.0192635522493242 0.97392758271909 NA NA NA 0.956083816283373 99.9038305363474 a11285 gain_cnaBRCA62 1261 rTRAIL TR10A (DR4), TR10B (DR5) 8 39 -2.30258509299405 NA -0.151657523659078 -0.138338797675032 -0.013318725984046 1.52576260225288 0.929974561389338 0.0127427372136223 0.00872922561110107 0.014321602479264 0.973954130586646 NA NA NA 0.981588281704238 99.9038305363474 a11286 gain_cnaBRCA14_(RAD21) 312 AV-951 VEGFR 21 27 -2.05572501506252 NA 0.63574864093418 0.629574787570039 0.00617385336414078 0.762840821374203 0.540192663392171 0.0095498385185684 0.00809323936416909 0.0114289841060997 0.973958426365464 NA NA NA 0.975085615975672 99.9038305363474 a11287 loss_cnaBRCA22_(SYNCRIP,ZNF292) 225 Genentech Cpd 10 AURKA, AURKB 19 30 2.32630161961136 NA 3.02755719236393 3.01205074141919 0.0155064509447485 1.93002149859874 1.40403362928934 0.00953826981124513 0.00803434104542703 0.011044216193452 0.974185666166163 NA NA NA 0.976022078380332 99.9038305363474 a11288 gain_cnaBRCA19 1016 Temsirolimus MTOR 4 40 -1.6094379124341 NA -1.77436590423817 -1.748598464603 -0.0257674396351741 2.00171943305242 1.46635973369542 0.0170543223794798 0.0128726529850797 0.0175723862590231 0.974210378400442 NA NA NA 0.981418987327245 99.9038305363474 a11289 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1032 Afatinib ERBB2, EGFR 6 39 -0.693147180559945 NA 0.267930912234392 0.293939511650639 -0.0260085994162474 2.46949842590871 1.74826064734124 0.0140841631963503 0.0105319360172003 0.0148768431388085 0.974527495400896 NA NA NA 0.981002318135636 99.9038305363474 a11290 BRCA1_mut 279 BIX02189 MAP2K5 (MEK5) 4 45 2.99573227355399 NA 5.04126402898213 5.02611977926196 0.0151442497201657 0.884382770781541 0.90817686657385 0.01670303081817 0.0171240895011812 0.0166754409604137 0.974596830922712 NA NA NA 0.975615599259038 99.9038305363474 a11291 gain_cnaBRCA12_(TERT) 204 Tipifarnib Farnesyl-transferase (FNTA) 9 39 2.77258872223978 NA 1.6053707625874 1.62334708863531 -0.0179763260479031 0.924586396304789 1.62394656233235 0.0117836897109063 0.0194425595268841 0.0110695305281998 0.974717553251829 NA NA NA 0.964860123776267 99.9038305363474 a11292 loss_cnaBRCA20 282 EKB-569 EGFR 3 44 0.916290731874155 2.99573227355399 1.54014659429767 1.58065296509002 -0.0405063707923508 0.120283197708506 2.18110256917028 0.0189971546942209 0.336758346668782 0.0185715112003008 0.974743153808947 NA NA NA 0.904599422044784 99.9038305363474 a11293 PIK3CA_mut 344 THZ-2-49 CDK9 17 32 2.99573227355399 NA 1.77604476946047 1.79017855289249 -0.0141337834320152 1.46659718218105 1.49405125180498 0.00951922377672153 0.00963712708829575 0.00946003921548209 0.974831418293639 NA NA NA 0.974740590016445 99.9038305363474 a11294 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 8 38 2.30258509299405 NA 1.42338198185374 1.41102605916557 0.0123559226881698 0.684561684927588 1.05250200712945 0.0123185324274651 0.0180493927139331 0.0117395716155153 0.974880250391301 NA NA NA 0.967275442519553 99.9038305363474 a11295 gain_cnaBRCA64_(SDHC) 274 PXD101, Belinostat HDAC 8 40 2.99573227355399 NA 0.656167566738239 0.674570501811393 -0.0184029350731546 2.45172846905322 1.26490471760695 0.0122111724543527 0.00750610653073718 0.0145488706121445 0.974983982426987 NA NA NA 0.984017278026868 99.9038305363474 a11296 gain_cnaBRCA48 190 Bleomycin DNA damage 5 43 4.15888308335967 NA 2.0415190166078 2.08268754466914 -0.0411685280613368 2.38709957836617 2.79759273808296 0.0148928304744114 0.0172462550094011 0.0147156973568452 0.974991805329289 NA NA NA 0.972728014306601 99.9038305363474 a11297 gain_cnaBRCA9_(KRAS) 1007 Docetaxel Microtubules 4 41 -4.38202663467388 NA -4.6106885284891 -4.58499586304306 -0.0256926654460434 0.576384631064041 1.60546887859144 0.0165128663873934 0.0445755560806908 0.0160032161249896 0.974997705992297 NA NA NA 0.947865797152476 99.9038305363474 a11298 gain_cnaBRCA8_(CHD4,WNK1) 231 FMK RSK 4 45 2.99573227355399 2.32630161961136 5.59818241700631 5.58843390006627 0.00974851694004197 0.973410395981113 0.563149737439794 0.016307083156179 0.0100148066840978 0.0173107013853206 0.975198813912784 NA NA NA 0.985425746350638 99.9038305363474 a11299 gain_cnaBRCA27_(CLTC,PPM1D) 281 CH5424802 ALK 9 39 1.63315443905142 NA 3.58530549258918 3.57291673376842 0.0123887588207583 1.43292139990823 0.980595428573364 0.0115454130617627 0.00864580487216657 0.0126339145174094 0.975228615288936 NA NA NA 0.980836594013557 99.9038305363474 a11300 loss_cnaBRCA34 150 Bicalutamide ANDR (androgen receptor) 5 43 0.0237165266173161 NA 2.75434429704919 2.76354628373218 -0.00920198668299665 0.261752188448066 0.652428577350706 0.014648711060749 0.0351553380988156 0.0141042054294477 0.975401597879331 NA NA NA 0.953283186890688 99.9038305363474 a11301 loss_cnaBRCA22_(SYNCRIP,ZNF292) 303 PIK-93 PI4K, PI3K 19 30 2.99573227355399 NA 2.78366567889969 2.79650616282059 -0.0128404839209 1.53523170387479 1.36480812934983 0.00896384907247969 0.00836387360194018 0.00940827039696556 0.975739765625335 NA NA NA 0.976425562196355 99.9038305363474 a11302 gain_cnaBRCA61_(NOTCH2) 262 VX-11e ERK 3 46 1.63315443905142 NA 3.79961326833638 3.77532490175129 0.0242883665850941 1.43527234457509 1.33614030117405 0.0181187773346706 0.0169224793307675 0.0181780061298594 0.975871395334828 NA NA NA 0.979598515489767 99.9038305363474 a11303 gain_cnaBRCA15 158 PF-562271 FAK 21 24 0.940007258491471 NA 2.32696805806895 2.33874708460291 -0.011779026533953 1.38988120775937 1.21512997015696 0.00906541678879681 0.00847484408609424 0.00969363510343793 0.975937323069294 NA NA NA 0.976165578642746 99.9038305363474 a11304 gain_cnaBRCA19 1529 MLN4924 NEDD8-activating enzyme 4 33 0 NA 0.344663031830955 0.372191301503521 -0.0275282696725659 1.90981005731665 1.69700728019129 0.0160394820244216 0.0144141400696382 0.0162216567918688 0.976003577722321 NA NA NA 0.979486989712304 99.9038305363474 a11305 loss_cnaBRCA28_(GPS2) 1047 Nutlin-3a MDM2 3 40 2.07944154167984 1.38629436111989 4.18998193932439 4.20821676521364 -0.018234825889242 0.658687402356715 1.02859699998269 0.0179885765860176 0.0276835807455853 0.0177278622138202 0.976172502770688 NA NA NA 0.967794585117815 99.9038305363474 a11306 ARID1A_mut 166 FTI-277 Farnesyl transferase (FNTA) 5 42 0.0237165266173161 NA 2.25476968664555 2.24315199106719 0.0116176955783627 0.752129675575799 0.827807680067443 0.0141444081138369 0.0154463996776469 0.0140342930587648 0.976280426618836 NA NA NA 0.975438395940156 99.9038305363474 a11307 loss_cnaBRCA33 283 GSK2126458 PI3K, MTOR 6 42 -2.05572501506252 0.0237165266173161 -3.03657803173303 -3.05804074290337 0.0214627111703396 0.701352440393418 1.72665113508181 0.0130359031755565 0.030601891337685 0.012430253416144 0.976300741775798 NA NA NA 0.956918408214458 99.9038305363474 a11308 loss_cnaBRCA38 1025 SB 216763 GSK3A, GSK3B 3 36 2.30258509299405 NA 4.90233207474727 4.88806377145248 0.0142683032947915 0.234117855314172 0.814585342396951 0.017967184196484 0.0609449598606833 0.017516032454999 0.976308141007509 NA NA NA 0.942546441991439 99.9038305363474 a11309 gain_cnaBRCA9_(KRAS) 1053 MK-2206 AKT1, AKT2 4 38 1.38629436111989 0.693147180559945 1.37029918239305 1.39636114447136 -0.0260619620783136 1.42887148454932 1.67638354694967 0.0157084798824157 0.0182395424362001 0.0155465389324153 0.976308581644211 NA NA NA 0.974466028616333 99.9038305363474 a11310 POLR2B_mut 201 Epothilone B Microtubules 3 45 -3.44201937618241 NA -4.20558473778618 -4.2377694705722 0.0321847327860194 2.3600712375153 1.78969164100615 0.0177012777839169 0.0136371869943654 0.0179833956021191 0.976445946106005 NA NA NA 0.983475053093389 99.9038305363474 a11311 loss_cnaBRCA18 1239 YK 4-279 RNA helicase A 14 28 2.30258509299405 NA 2.02201102347127 2.00932380848842 0.0126872149828552 1.0164378214205 1.42438125292135 0.00971564712492506 0.0124820374797983 0.00890717633136088 0.976468437513197 NA NA NA 0.973724230240171 99.9038305363474 a11312 gain_cnaBRCA9_(KRAS) 1170 CCT018159 HSP90 3 40 2.30258509299405 NA 3.32298265427249 3.34431684195549 -0.021334187683006 0.286622265692532 1.23007804725669 0.017758214604725 0.074433113671259 0.0173437675199434 0.976477545779248 NA NA NA 0.935015879609515 99.9038305363474 a11313 gain_cnaBRCA15 179 5-Fluorouracil DNA antimetabolite 22 27 3.46573590279973 NA 4.03384529962333 4.04769485640484 -0.0138495567815129 1.74858388187599 1.52799917065502 0.00849535193402264 0.00792044175007161 0.00906385098074095 0.976528435078602 NA NA NA 0.976868363433049 99.9038305363474 a11314 loss_cnaBRCA18 1072 BMS-708163 g-secretase 15 31 1.6094379124341 NA 3.69027156150801 3.6813359983007 0.00893556320730937 0.982315650546137 0.953101111934223 0.00928377111121823 0.00909642761198142 0.00937525210643763 0.976585753606787 NA NA NA 0.976918206049409 99.9038305363474 a11315 gain_cnaBRCA47_(EGFR) 192 LFM-A13 BTK 7 41 2.77258872223978 NA 4.80415754063444 4.79398690683257 0.0101706338018737 0.886932484682613 0.836342924841088 0.012063181347633 0.0114672018192154 0.0121608415636519 0.976595584833284 NA NA NA 0.97814557257322 99.9038305363474 a11316 gain_cnaBRCA47_(EGFR) 166 FTI-277 Farnesyl transferase (FNTA) 7 40 0.0237165266173161 NA 2.25273081220041 2.24292790931617 0.00980290288424035 0.678238405761642 0.841224237866642 0.0119349132839024 0.0144534765371064 0.0116531388932643 0.976889247673907 NA NA NA 0.973620658521411 99.9038305363474 a11317 loss_cnaBRCA28_(GPS2) 1046 681640 WEE1, CHEK1 3 33 0.693147180559945 NA 2.61643048239862 2.63537346552843 -0.0189429831298087 1.04729054777935 1.07919504429148 0.0175830328811407 0.0180876101383469 0.0175528818724749 0.976908934692488 NA NA NA 0.978436630440602 99.9038305363474 a11318 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1017 Olaparib PARP1, PARP2 6 39 1.6094379124341 NA 4.08398726594478 4.07257668733672 0.0114105786080616 0.659945389450841 0.923277539211958 0.0127259323118586 0.0172901861130611 0.0123587741750989 0.976983237721906 NA NA NA 0.971252772091605 99.9038305363474 a11319 gain_cnaBRCA9_(KRAS) 1264 SGC0946 Q8TEK3 (DOT1L) 4 42 -0.693147180559945 NA 1.95915553371126 1.94990967566491 0.00924585804635103 0.305433652959506 0.628340578551861 0.0151134723299995 0.0302712486222886 0.0147147237691699 0.977088637299273 NA NA NA 0.960940539785682 99.9038305363474 a11320 gain_cnaBRCA14_(RAD21) 1149 TW 37 BCL2, BCL2L1 20 23 1.6094379124341 NA -0.148306179438819 -0.13723473175931 -0.0110714476795088 0.995917357727287 1.44603091166075 0.00880339944266973 0.0111168337348535 0.00765643914679073 0.977168953797752 NA NA NA 0.97658712485622 99.9038305363474 a11321 loss_cnaBRCA18 202 GSK-1904529A IGF1R 16 32 0.0237165266173161 NA 2.18477710506115 2.1921230848234 -0.00734597976224638 0.516755177583749 0.956939405300773 0.00875389429824582 0.0142155900529044 0.0076765359661801 0.977315189074927 NA NA NA 0.972619422987111 99.9038305363474 a11322 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1046 681640 WEE1, CHEK1 6 30 0.693147180559945 NA 2.62230490605521 2.6360928791101 -0.0137879730548907 1.01823668361586 1.08721129690231 0.0127981042135256 0.0135410295825605 0.0126819626453252 0.977337030915612 NA NA NA 0.97690562704049 99.9038305363474 a11323 loss_cnaBRCA29_(MAP2K4) 257 NPK76-II-72-1 PLK3 7 42 2.32630161961136 NA 3.49476525470799 3.47632613746187 0.0184391172461162 1.31662470906137 1.63341581965186 0.0115498692358406 0.0140048391308573 0.0112886853575633 0.977549620465252 NA NA NA 0.974322945242097 99.9038305363474 a11324 loss_cnaBRCA38 153 Midostaurin KIT 4 43 -0.669430653942629 NA 0.631987853900286 0.610341851587182 0.0216460023131048 1.29163555818138 1.47854311997162 0.0147570573535899 0.0167585989530842 0.0146400886255656 0.977603321848324 NA NA NA 0.97635883060111 99.9038305363474 a11325 gain_cnaBRCA58_(CCND1) 235 QL-XII-47 BTK, BMX 10 39 2.32630161961136 NA 1.72013960525981 1.70498163060545 0.0151579746543631 1.85190592151501 1.42400915579128 0.0100030893880481 0.00818506732888602 0.0106445766817702 0.977605585995307 NA NA NA 0.981157912627056 99.9038305363474 a11326 gain_cnaBRCA12_(TERT) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 9 34 1.6094379124341 NA 2.85599639733043 2.87112551446487 -0.015129117134439 1.42405209042324 1.44305109690607 0.0105109761278653 0.0106239913807805 0.0104841174140515 0.977766725520228 NA NA NA 0.97789235388989 99.9038305363474 a11327 POLR2B_mut 225 Genentech Cpd 10 AURKA, AURKB 3 46 2.32630161961136 NA 2.99290155697624 3.01970443970786 -0.0268028827316162 1.16080248985407 1.64332687802154 0.0164868371110648 0.0230899597182858 0.0163101346969296 0.978044040402209 NA NA NA 0.972738293452036 99.9038305363474 a11328 gain_cnaBRCA10_(MDM2,NUP107) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 39 1.38629436111989 0.693147180559945 3.4495356211135 3.43219087980383 0.0173447413096777 1.06701665874235 1.05257883031592 0.0164669629044451 0.0162553613081555 0.0164783299930817 0.978210274626475 NA NA NA 0.980502288647189 99.9038305363474 a11329 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 308 XL-880 MET 6 43 1.63315443905142 NA 1.83102687004486 1.85005976292598 -0.0190328928811236 1.44978668307885 1.6349230889976 0.0117760599752818 0.0131280643582022 0.0116414606957402 0.978556878445138 NA NA NA 0.977196319753845 99.9038305363474 a11330 loss_cnaBRCA34 171 AKT inhibitor VIII AKT1, AKT2, AKT3 5 42 0.940007258491471 NA 1.90303648265043 1.88694706120049 0.0160894214499381 1.59064552178338 1.22639646963985 0.0127386971715305 0.0101150264025508 0.0131192659537442 0.978637129878917 NA NA NA 0.983480571465309 99.9038305363474 a11331 ARID1A_mut 330 XMD13-2 RIPK 5 43 2.32630161961136 NA 3.70711507824823 3.7226382403815 -0.0155231621332712 0.860766887872907 1.25501587621577 0.0126639313535632 0.0180341069713212 0.0123688970215086 0.978733599573084 NA NA NA 0.972332719658338 99.9038305363474 a11332 loss_cnaBRCA22_(SYNCRIP,ZNF292) 283 GSK2126458 PI3K, MTOR 18 30 -2.05572501506252 0.0237165266173161 -3.06357543592683 -3.05042738485523 -0.0131480510716022 1.91694671759026 1.4648125625019 0.00798577560242662 0.00685885056217436 0.00897592730167834 0.978746999195208 NA NA NA 0.980193644196982 99.9038305363474 a11333 loss_cnaBRCA28_(GPS2) 166 FTI-277 Farnesyl transferase (FNTA) 4 43 0.0237165266173161 NA 2.23391916749295 2.24536175321112 -0.011442585718171 0.49923297212065 0.839658479036152 0.0139311854840735 0.0229203325044118 0.0136276664904355 0.978856429255327 NA NA NA 0.969119545606791 99.9038305363474 a11334 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 133 Doxorubicin DNA intercalating 6 42 0.0237165266173161 NA -1.04941164786605 -1.0279640314865 -0.0214476163795496 1.07435997444614 1.92227160115511 0.0115993308349881 0.0199631565673381 0.011157432886519 0.97891176164055 NA NA NA 0.968459661501843 99.9038305363474 a11335 gain_cnaBRCA61_(NOTCH2) 275 I-BET BRD2, BRD3, BRD4 3 46 2.99573227355399 NA 4.05928713846225 4.03761414112762 0.0216729973346261 1.81343528665364 1.34623115935388 0.0158270620459998 0.011951348633245 0.0160990162677768 0.978922465016634 NA NA NA 0.98550784985865 99.9038305363474 a11336 POLR2B_mut 1031 Elesclomol HSP70 3 41 -1.6094379124341 NA -3.00420274345628 -2.97563099694497 -0.0285717465113065 2.86973613230682 1.72932079536891 0.0158724467550032 0.00995622774848614 0.016521946990877 0.978953827392956 NA NA NA 0.987895512696183 99.9038305363474 a11337 gain_cnaBRCA58_(CCND1) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 9 37 2.30258509299405 NA 1.40522402534449 1.41510891554111 -0.00988489019661642 0.571389406693013 1.07569002718167 0.00985494395667045 0.0172997435388704 0.00918934818287295 0.978966187026003 NA NA NA 0.969978472808916 99.9038305363474 a11338 gain_cnaBRCA10_(MDM2,NUP107) 309 Y-39983 ROCK 5 44 2.99573227355399 NA 4.92281916151879 4.93636294608545 -0.013543784566667 1.1642706330828 1.08437444431556 0.0124095305484249 0.0116328490832112 0.0124899518221454 0.979133591598008 NA NA NA 0.981194487919788 99.9038305363474 a11339 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 157 JNK-9L JNK 9 38 1.63315443905142 NA 0.064230339497088 0.053858130061813 0.010372209435275 0.773949948695121 1.11677249085154 0.00974895271545831 0.0134016540123331 0.00928766559012047 0.979135958751199 NA NA NA 0.974136703511572 99.9038305363474 a11340 gain_cnaBRCA27_(CLTC,PPM1D) 1241 CHIR-99021 GSK3B 10 36 2.30258509299405 NA 4.23873746701767 4.22947309956174 0.00926436745592341 1.07797149537793 0.960163861356265 0.00940156126520505 0.00859426014105817 0.00964873583435765 0.979136181251271 NA NA NA 0.98073982451148 99.9038305363474 a11341 gain_cnaBRCA13_(FGFR1,WHSC1L1) 286 KIN001-236 TIE2 11 38 2.32630161961136 NA 4.54549595762926 4.53854315849001 0.00695279913924374 0.730586555390676 0.783715260015929 0.00899785659417102 0.00951673568031344 0.00887158831015033 0.979145092171274 NA NA NA 0.978504586445332 99.9038305363474 a11342 loss_cnaBRCA18 1030 KU-55933 ATM 12 30 2.30258509299405 NA 4.22826842820278 4.21991172578593 0.00835670241684472 1.17384765914034 0.819236263866464 0.00898253508360834 0.00711906894542406 0.0102006012006896 0.979150280202283 NA NA NA 0.98228858970281 99.9038305363474 a11343 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 276 CAY10603 HDAC6 9 40 2.99573227355399 NA 1.18341442991077 1.17376794137637 0.00964648853439476 0.502879634567839 1.07293939079319 0.00965472301253547 0.0191824998892323 0.00899071151378216 0.979233057253315 NA NA NA 0.968034022961901 99.9038305363474 a11344 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1133 JNJ-26854165 MDM2 13 30 2.30258509299405 NA 2.96348532308457 2.97112564587829 -0.00764032279372451 0.992024549096345 0.828861931598408 0.0086846055802941 0.0077017477044134 0.00921784739104935 0.979260912562477 NA NA NA 0.980833952030972 99.9038305363474 a11345 gain_cnaBRCA15 253 XMD14-99 EPHB3, CAMK1 22 26 2.32630161961136 NA 4.92991373796111 4.93579946521378 -0.00588572725267422 0.755500382464719 0.79813397231912 0.00755587542969514 0.00779050201599214 0.00737436001574046 0.979303742282018 NA NA NA 0.979208429256318 99.9038305363474 a11346 loss_cnaBRCA36_(FAT1,IRF2) 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 3 23 2.30258509299405 NA 4.69997749769977 4.68394145882595 0.0160360388738185 0.246854949945039 1.0495306407797 0.0159186749226703 0.0649613826961497 0.0152792479330621 0.979525582726256 NA NA NA 0.951849921133117 99.9038305363474 a11347 loss_cnaBRCA38 211 TL-2-105 CRAF 4 45 2.32630161961136 1.63315443905142 3.89401357707799 3.90875730624783 -0.014743729169842 0.730940925845834 1.11695432404754 0.0134476043899829 0.0201708902163069 0.0131999392028984 0.97954666220444 NA NA NA 0.972334771738042 99.9038305363474 a11348 PIK3CA_mut 192 LFM-A13 BTK 17 31 2.77258872223978 NA 4.79970133229612 4.79314978437234 0.00655154792378454 0.999597038016352 0.746362609289459 0.00777063989463667 0.00655418901279033 0.0087779691027417 0.979569810420263 NA NA NA 0.981313096176278 99.9038305363474 a11349 CDH1_mut 219 AT-7519 CDK9 4 45 2.32630161961136 NA 1.69449481698166 1.67000100882271 0.024493808158955 1.31658783030664 1.85514995137059 0.0134173904707759 0.0186040062008246 0.0132031419567237 0.97959260616662 NA NA NA 0.974224107069592 99.9038305363474 a11350 loss_cnaBRCA29_(MAP2K4) 330 XMD13-2 RIPK 7 41 2.32630161961136 NA 3.71001872789931 3.72289972274026 -0.0128809948409483 1.08707411528467 1.245252069908 0.0105084215471555 0.0118492333317818 0.0103440862715449 0.979611327998029 NA NA NA 0.978017621756208 99.9038305363474 a11351 gain_cnaBRCA31 151 QS11 ARFGAP 16 32 2.32630161961136 NA 3.7526748972727 3.76433739049703 -0.0116624932243323 1.46721900025374 1.50387745328493 0.00781656618166199 0.00794870651369386 0.00775494918077123 0.979743606447053 NA NA NA 0.979627524168889 99.9038305363474 a11352 loss_cnaBRCA36_(FAT1,IRF2) 279 BIX02189 MAP2K5 (MEK5) 9 40 2.99573227355399 NA 5.03431960369572 5.02578924373639 0.00853035995933205 0.856371280030716 0.916658957269472 0.00940834311506824 0.0099610532934104 0.00930592549353594 0.979762892210831 NA NA NA 0.979163732889494 99.9038305363474 a11353 PIK3CA_mut 196 Phenformin AAPK1 (AMPK) agonist 17 31 8.29404964010203 NA 7.2110728911454 7.19704480274031 0.0140280884050901 2.20959937393983 1.58264331869558 0.00768533680843292 0.00634870219938434 0.00886370810111027 0.979794035354756 NA NA NA 0.981732834814575 99.9038305363474 a11354 gain_cnaBRCA64_(SDHC) 190 Bleomycin DNA damage 8 40 4.15888308335967 NA 2.10106593251636 2.07386580109203 0.0272001314243324 3.08526001768258 2.70269517203876 0.00983968660052303 0.00881615528948617 0.0100640766689993 0.979841052478843 NA NA NA 0.981968482947681 99.9038305363474 a11355 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 203 BMS-345541 IKBKB 9 40 2.77258872223978 NA 3.52458449994313 3.53407536567362 -0.00949086573049929 0.41392524810751 1.09912304504149 0.00934434786201163 0.0229289365021633 0.00863494380662451 0.979900514218089 NA NA NA 0.966124958256969 99.9038305363474 a11356 loss_cnaBRCA7_(FAS,PTEN) 1129 PF-4708671 RPS6KB1 (p70S6KA) 4 39 2.30258509299405 NA 3.79506752578944 3.81039250258308 -0.0153249767936421 0.849249510315148 1.17538230581706 0.0132724379779385 0.0180453171977163 0.013038291216226 0.979954191445616 NA NA NA 0.975160297141999 99.9038305363474 a11357 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 329 QL-XI-92 DDR1 9 39 2.32630161961136 NA 4.24610782175496 4.25500293121674 -0.00889510946178262 0.742710220662334 0.992577773219706 0.00932561629268831 0.0119765545354286 0.00896162467242121 0.979990169808537 NA NA NA 0.97626788677805 99.9038305363474 a11358 loss_cnaBRCA36_(FAT1,IRF2) 1004 Vinblastine Microtubules 8 37 -2.30258509299405 NA -3.4659937235372 -3.45330449232338 -0.0126892312138263 1.20484538752048 1.31028821705728 0.00980841317920246 0.0105318336653471 0.00968430536781022 0.980047064245163 NA NA NA 0.979272851038491 99.9038305363474 a11359 loss_cnaBRCA22_(SYNCRIP,ZNF292) 309 Y-39983 ROCK 19 30 2.99573227355399 NA 4.93006993022159 4.93809122537146 -0.00802129514986483 1.24550535626832 0.983684069556901 0.00734952921952562 0.00644019321915852 0.00815434080728582 0.980107808992336 NA NA NA 0.981186065745492 99.9038305363474 a11360 gain_cnaBRCA14_(RAD21) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 21 26 2.99573227355399 NA 3.8534210753463 3.84301108965421 0.0104099856920938 1.42133429447682 1.45235359762738 0.00723594136350687 0.00732409379872568 0.0071676661310992 0.98043296864697 NA NA NA 0.980391237463482 99.9038305363474 a11361 POLR2B_mut 235 QL-XII-47 BTK, BMX 3 46 2.32630161961136 NA 1.72895505623164 1.70671335820686 0.0222416980247822 0.950402977621442 1.53562424973707 0.0146777686096667 0.0234023867227837 0.0144838153139288 0.980452696817635 NA NA NA 0.972674519106163 99.9038305363474 a11362 gain_cnaBRCA58_(CCND1) 253 XMD14-99 EPHB3, CAMK1 10 38 2.32630161961136 NA 4.92772579763498 4.93451658827245 -0.00679079063746624 0.863214608983134 0.757050391385607 0.00871775433077143 0.00786686250070047 0.008970064231837 0.980536933670081 NA NA NA 0.982247616713565 99.9038305363474 a11363 gain_cnaBRCA13_(FGFR1,WHSC1L1) 221 TAK-715 p38a 11 38 2.99573227355399 2.32630161961136 4.48874488424062 4.4802444540589 0.00850043018171842 1.18873923938521 0.961476962190886 0.00838219985068795 0.00715079464030701 0.00884101285417049 0.980571737367631 NA NA NA 0.982956754371612 99.9038305363474 a11364 gain_cnaBRCA31 154 CHIR-99021 GSK3B 16 31 0.940007258491471 NA 3.27093933032938 3.27775816450883 -0.00681883417944551 0.996201160609266 0.868427490823748 0.00746853934186115 0.00684483661439943 0.00785193266161749 0.980750850631651 NA NA NA 0.98165794978552 99.9038305363474 a11365 loss_cnaBRCA34 1038 NU-7441 PRKDC (DNAPK) 5 38 0.693147180559945 NA 2.90255922228541 2.89158946217126 0.0109697601141425 0.539907037429205 0.98718091664554 0.0115127918233963 0.0203178683618861 0.011112208440392 0.980810131990924 NA NA NA 0.970712005759741 99.9038305363474 a11366 PTEN_mut 305 TPCA-1 IKK 9 40 2.99573227355399 NA 4.18842901460531 4.17605326964554 0.0123757449597708 1.81826403298914 1.28622778047108 0.00889553793493341 0.00680635195727083 0.00962173663768809 0.980865698590794 NA NA NA 0.984940719044218 99.9038305363474 a11367 loss_cnaBRCA36_(FAT1,IRF2) 257 NPK76-II-72-1 PLK3 9 40 2.32630161961136 NA 3.49055164803854 3.47635224310019 0.0141994049383549 1.93559514382653 1.51758302091802 0.00889418325366801 0.00733593746793751 0.00935659185865523 0.980868611933572 NA NA NA 0.983935997667918 99.9038305363474 a11368 gain_cnaBRCA19 196 Phenformin AAPK1 (AMPK) agonist 4 44 8.29404964010203 NA 7.18100984146284 7.20392246974023 -0.0229126282773882 2.48721038253334 1.76991430393431 0.0125527530938885 0.00921217941123685 0.0129456145003496 0.980927311060275 NA NA NA 0.986667428154835 99.9038305363474 a11369 gain_cnaBRCA15 164 JQ12 HDAC 22 25 1.63315443905142 NA 1.57175059290687 1.58327984030022 -0.0115292473933493 1.59031799928641 1.70805739705739 0.00696986884095973 0.00724964906296889 0.00674991801400331 0.981083426431277 NA NA NA 0.980995612626432 99.9038305363474 a11370 gain_cnaBRCA9_(KRAS) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 4 44 2.77258872223978 NA -0.420350002350423 -0.437997856010087 0.0176478536596637 1.16315832506714 1.43465984797468 0.0124408740600138 0.0151723572615491 0.0123010717032175 0.981097267383348 NA NA NA 0.978711707429448 99.9038305363474 a11371 POLR2B_mut 204 Tipifarnib Farnesyl-transferase (FNTA) 3 45 2.77258872223978 NA 1.59984248824579 1.62131879678503 -0.021476308539232 0.797467569775231 1.5505257862577 0.0140778986497713 0.0269306356185558 0.0138509844399728 0.981266331558247 NA NA NA 0.969268866394757 99.9038305363474 a11372 loss_cnaBRCA42 201 Epothilone B Microtubules 3 45 -3.44201937618241 NA -4.21192386228778 -4.23734686227209 0.0254229999843121 2.09181814790631 1.80480037417442 0.0139823427094653 0.0121535421278173 0.0140863224255156 0.981393465372258 NA NA NA 0.985318431438199 99.9038305363474 a11373 gain_cnaBRCA19 165 DMOG Prolyl-4-Hydroxylase 4 42 8.29404964010203 NA 7.58725367901331 7.56833552062995 0.0189181583833671 1.2036163624561 1.5694295887816 0.0122270537979706 0.0157177643753219 0.0120541619188242 0.981463410943937 NA NA NA 0.978117692980591 99.9038305363474 a11374 gain_cnaBRCA9_(KRAS) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 4 42 0 NA 0.676274959694484 0.651018972633529 0.025255987060955 0.651455064800259 2.14332396964068 0.012166005629994 0.0387685788715123 0.0117835602170721 0.981555944744412 NA NA NA 0.957545127358722 99.9038305363474 a11375 loss_cnaBRCA34 254 AC220 FLT3 5 43 0.0237165266173161 NA 2.23249825302526 2.22274604187314 0.00975221115211466 0.567835506315122 0.914735330200382 0.0109581031666197 0.0171743595524698 0.010661238098214 0.981597612514812 NA NA NA 0.974126878696035 99.9038305363474 a11376 loss_cnaBRCA42 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 3 42 -0.669430653942629 NA -3.51789753948162 -3.4839267724201 -0.033970767061521 2.67502110661238 2.43928765897959 0.0138613484974515 0.0126992519713391 0.0139265112650681 0.981602450728514 NA NA NA 0.984700909514524 99.9038305363474 a11377 gain_cnaBRCA9_(KRAS) 225 Genentech Cpd 10 AURKA, AURKB 4 45 2.32630161961136 NA 3.00001160100569 3.01966805541039 -0.0196564544046995 1.29632462941301 1.64577766475932 0.0120909372866246 0.0151632191186556 0.0119435661484531 0.981609707238988 NA NA NA 0.978759372247147 99.9038305363474 a11378 gain_cnaBRCA12_(TERT) 1018 ABT-888 PARP1, PARP2 10 35 1.6094379124341 NA 4.40735191806157 4.40185455601061 0.00549736205096529 0.741032512188461 0.649594064973902 0.00820788320450267 0.007418516678479 0.00846276520581535 0.981843361512153 NA NA NA 0.983369141775473 99.9188282909933 a11379 loss_cnaBRCA34 208 SB-715992 KIF11 5 44 -2.05572501506252 NA -1.22347673882358 -1.24176548183334 0.0182887430097587 0.829871818376305 1.78108104043726 0.0106285313840633 0.0220380335911897 0.0102683384947317 0.982127750165011 NA NA NA 0.969019502841931 99.9223798084331 a11380 gain_cnaBRCA15 1072 BMS-708163 g-secretase 22 24 1.6094379124341 NA 3.68758025511769 3.68119682322303 0.00638343189466051 1.09612837925805 0.821720409248307 0.0066321587698099 0.00582361702830953 0.00776837452595335 0.982175051738147 NA NA NA 0.982409353480009 99.9223798084331 a11381 gain_cnaBRCA12_(TERT) 1143 HG-5-88-01 EGFR, ADCK4 5 21 2.30258509299405 NA 4.52509071335939 4.53621665067916 -0.0111259373197701 0.483797112375674 1.06556283021812 0.0112092131699095 0.0229971139454232 0.010441371455771 0.98221465418534 NA NA NA 0.972528567682857 99.9223798084331 a11382 loss_cnaBRCA29_(MAP2K4) 328 SNX-2112 HSP90 7 41 0.940007258491471 NA 0.433324546235743 0.414493807336601 0.0188307388991423 2.36850314469645 2.00414522108159 0.00916187656030041 0.00795048085171772 0.00939589541768826 0.982223445012165 NA NA NA 0.984673332299942 99.9223798084331 a11383 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 255 CP724714 ERBB2 9 39 2.32630161961136 NA 3.7918067972656 3.80562696705512 -0.0138201697895175 1.77783150131729 1.66017846210325 0.00822026628729277 0.00777361059204847 0.00832450854229788 0.982361476223918 NA NA NA 0.983390344851827 99.9266430935767 a11384 gain_cnaBRCA58_(CCND1) 196 Phenformin AAPK1 (AMPK) agonist 10 38 8.29404964010203 NA 7.2133035430043 7.19904191064154 0.0142616323627669 1.31280839384498 1.92949667127644 0.00781327064564678 0.0108634530595871 0.00739137443203376 0.982555912433149 NA NA NA 0.978381448208572 99.9266430935767 a11385 gain_cnaBRCA30_(CRNKL1,FOXA2) 238 CAL-101 PI3Kdelta 5 44 2.99573227355399 2.32630161961136 4.72779069372553 4.71796121098958 0.00982948273595508 0.460625430500755 0.985839040201011 0.0103198557176802 0.0213394269727341 0.00997067709344403 0.982646713421576 NA NA NA 0.969975205708723 99.9266430935767 a11386 BRCA1_mut 1072 BMS-708163 g-secretase 4 42 1.6094379124341 NA 3.67423158524745 3.68520388164172 -0.010972296394268 0.464262977855666 0.989148630022602 0.0113998219042564 0.0236337957528872 0.0110926670282274 0.982717309633466 NA NA NA 0.969762342343931 99.9266430935767 a11387 loss_cnaBRCA17 154 CHIR-99021 GSK3B 10 37 0.940007258491471 NA 3.2810140609401 3.27392950744981 0.00708455349029213 0.918005956753276 0.911755352594625 0.00775956676302656 0.00771732845323593 0.00777023515149243 0.982726440131897 NA NA NA 0.983001780118228 99.9266430935767 a11388 gain_cnaBRCA62 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 8 38 0 NA 0.63881380208072 0.656247007177379 -0.0174332050966589 3.62836038001812 1.62302563689398 0.00839770353325868 0.00480470605749804 0.0107411766643571 0.982873973710153 NA NA NA 0.989721465070327 99.9266430935767 a11389 PIK3CA_mut 60 BI-2536 PLK1, PLK2, PLK3 4 8 -1.36257783450257 NA -1.48330911662033 -1.505129354148 0.0218202375276682 1.9239658425423 1.48644498177035 0.0133860027878185 0.0113412811418914 0.0146794787531795 0.982990254396522 NA NA NA 0.984907932198636 99.9266430935767 a11390 loss_cnaBRCA24 192 LFM-A13 BTK 3 45 2.77258872223978 NA 4.78538761225374 4.79614229172923 -0.0107546794754878 1.43954409565179 0.805582704095853 0.0127558488233217 0.00747089269996857 0.0133501866671261 0.983025314475085 NA NA NA 0.99090258421062 99.9266430935767 a11391 CDH1_mut 1194 SB-505124 TGFR1 (ALK5) 5 42 2.30258509299405 NA 4.3973589132634 4.3880038721 0.00935504116340002 1.55889785151003 0.838080930415337 0.0101115766936136 0.00600106104087463 0.0111624555861972 0.983042051540662 NA NA NA 0.990065665532761 99.9266430935767 a11392 gain_cnaBRCA9_(KRAS) 196 Phenformin AAPK1 (AMPK) agonist 4 44 8.29404964010203 NA 7.22049490671658 7.20033291835353 0.0201619883630562 1.92369945248638 1.81824652182738 0.0110457909949732 0.0104808411402295 0.011088698986094 0.983216620942156 NA NA NA 0.985010541328358 99.9356149393366 a11393 gain_cnaBRCA64_(SDHC) 200 LAQ824 HDAC 8 40 0.0237165266173161 NA -2.6938851543813 -2.68258386098573 -0.0113012933955732 0.741101633935833 1.51150384124044 0.00795046151342415 0.0152493165283612 0.00747685390352603 0.983710959718523 NA NA NA 0.974880632604573 99.9723356954986 a11394 TP53_mut 173 FH535 unknown 38 10 3.46573590279973 NA 1.57105063952476 1.58039830675279 -0.00934766722802594 1.36028061289029 0.946796247318366 0.00724707490404665 0.0068718668335383 0.00987294494935058 0.983819828067495 NA NA NA 0.980198387089906 99.9723356954986 a11395 MACF1_mut 1005 Cisplatin DNA crosslinker 3 42 1.79175946922805 2.30258509299405 3.68355961091782 3.6691209759196 0.0144386349982182 1.16179465930731 1.19369788317412 0.012110582153757 0.01242787172634 0.0120957196973701 0.983925815772239 NA NA NA 0.985094385700225 99.9723356954986 a11396 POLR2B_mut 308 XL-880 MET 3 46 1.63315443905142 NA 1.82943410633035 1.84892236319772 -0.0194882568673707 0.464229814480775 1.64886569445634 0.01205776232485 0.0419797614445931 0.0118191899636776 0.983941384000477 NA NA NA 0.958679158841796 99.9723356954986 a11397 loss_cnaBRCA33 260 NG-25 MAP3K7 (TAK1) 6 43 2.32630161961136 NA 3.19854745672553 3.20971028113344 -0.0111628244079052 0.895810221525145 1.33433025614561 0.008621551422658 0.0124611487340478 0.00836586321601556 0.984300042967835 NA NA NA 0.979337978294448 99.9723356954986 a11398 gain_cnaBRCA48 308 XL-880 MET 5 44 1.63315443905142 NA 1.83423411710048 1.849262737286 -0.0150286201855176 1.47407952786176 1.62883569420955 0.0092984965510967 0.0101952573802565 0.00922660292805704 0.984363933899063 NA NA NA 0.983754781961401 99.9723356954986 a11399 loss_cnaBRCA22_(SYNCRIP,ZNF292) 178 BAY 61-3606 SYK 18 30 2.07944154167984 NA 3.10167683428744 3.0921984140841 0.00947842020333844 1.62546385317557 1.61474630600214 0.00585551986041007 0.00583120946357623 0.00586991291951336 0.984415490266624 NA NA NA 0.984466036410044 99.9723356954986 a11400 MLL3_mut 1378 Bleomycin (50 uM) DNA damage 3 45 3.91202300542815 NA 3.79202474340434 3.81409713782173 -0.0220723944173886 2.08857205346478 1.89130352546048 0.0116151772741835 0.0105681747396611 0.0116704664905727 0.984543043021721 NA NA NA 0.987251093467161 99.9723356954986 a11401 CDH1_mut 1020 Lenalidomide TNFA 4 41 1.6094379124341 NA 4.26132253964156 4.25408306832245 0.0072394713191084 1.13694012887281 0.673975748694695 0.0101102085504333 0.00636750444043677 0.0107414418591904 0.984690411697971 NA NA NA 0.990747340969167 99.9723356954986 a11402 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 333 T0901317 LXR 14 34 2.32630161961136 NA 4.73209965248831 4.73681008101734 -0.0047104285290267 0.858002731134568 0.732835709459331 0.00611526702279593 0.00548999246517308 0.00642767330825342 0.984719034036019 NA NA NA 0.985796288024143 99.9723356954986 a11403 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1036 PLX4720 BRAF 8 35 2.30258509299405 NA 4.58926268967672 4.59829636258818 -0.00903367291146129 1.04653769013491 1.24394497588102 0.00745033747912677 0.00863196136805806 0.0072621161599718 0.984924000285123 NA NA NA 0.98341376605524 99.9723356954986 a11404 gain_cnaBRCA26_(CDK12,ERBB2,MED24) 1047 Nutlin-3a MDM2 15 28 2.07944154167984 1.38629436111989 4.21095267276153 4.20479736911056 0.00615530365096628 0.882637290457679 1.07538237107897 0.00607214013088099 0.00697376342186329 0.00572382792995799 0.984951344951178 NA NA NA 0.984035060940968 99.9723356954986 a11405 loss_cnaBRCA28_(GPS2) 203 BMS-345541 IKBKB 4 45 2.77258872223978 NA 3.52314101138532 3.53314913513093 -0.0100081237456062 0.537734617298534 1.04030457114178 0.00985359070478719 0.0186116411769898 0.00962037851532447 0.985012247085957 NA NA NA 0.975459239097869 99.9723356954986 a11406 gain_cnaBRCA31 224 AS605240 PI3Kgamma 16 33 2.99573227355399 2.32630161961136 3.2640966468244 3.27324346568723 -0.00914681886282942 1.05673806103606 1.78912904278945 0.00574399292872846 0.0086557106250735 0.00511244222416093 0.98503637912537 NA NA NA 0.982230733297523 99.9723356954986 a11407 loss_cnaBRCA17 29 AZ628 BRAF 4 10 1.38629436111989 NA 2.46904028605135 2.49290648503091 -0.023866198979559 1.02847800904321 2.36888316200831 0.0112843528037036 0.0232053566237762 0.010074873831821 0.985095522616453 NA NA NA 0.979487974542505 99.9723356954986 a11408 PTEN_mut 1023 GW 441756 NTRK1 7 38 0.693147180559945 NA 2.36784464496777 2.35771034409178 0.010134300875984 0.995462175751338 1.35664698466422 0.00772295599315324 0.0101804981875228 0.00747010901918032 0.985106137830487 NA NA NA 0.981882608226299 99.9723356954986 a11409 PIK3CA_mut 208 SB-715992 KIF11 17 32 -2.05572501506252 NA -1.24620879951344 -1.23654735322051 -0.00966144629292187 1.9882560385332 1.56484933934394 0.00561475511814785 0.00485925660763965 0.00617404247809085 0.985153074947587 NA NA NA 0.98626334200311 99.9723356954986 a11410 gain_cnaBRCA12_(TERT) 1010 Gefitinib EGFR 10 35 -0.693147180559945 NA 1.39444273532654 1.40145640877931 -0.00701367345277659 0.984086194594586 1.06692294463205 0.00667888840690522 0.00712709261780267 0.00657373945144222 0.985225201139759 NA NA NA 0.984689529654883 99.9723356954986 a11411 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 304 SB52334 ALK5 6 43 2.99573227355399 NA 4.29279456900143 4.30316112160945 -0.010366552608021 1.60126450661242 1.23947822234138 0.00808103287195728 0.0064739788868187 0.00836364239497372 0.985284215203013 NA NA NA 0.988350430093427 99.9723356954986 a11412 loss_cnaBRCA60 1268 XAV 939 TNKS1 (tankyrase-1) 3 44 1.6094379124341 NA 3.65164925915383 3.66211041940039 -0.0104611602465616 0.530750085160065 0.961517910198232 0.0110519453067484 0.0197101433217985 0.0108798391955121 0.985304685168866 NA NA NA 0.977326295456468 99.9723356954986 a11413 loss_cnaBRCA36_(FAT1,IRF2) 1061 SB590885 BRAF 9 33 1.6094379124341 NA 4.0059685126645 4.01353256471035 -0.00756405204585064 0.823206526137146 1.1558233614573 0.00689273384022182 0.00918852293524028 0.00654429759605626 0.98546730474537 NA NA NA 0.982514026956967 99.9800746661407 a11414 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1166 QL-VIII-58 MTOR, ATR 3 23 2.30258509299405 NA -1.50784921145213 -1.52048505551245 0.0126358440603134 1.73682145548261 1.06731362422854 0.011101138443848 0.00727526944144195 0.0118389232306921 0.985720986672257 NA NA NA 0.991210042953991 99.9934512883142 a11415 loss_cnaBRCA7_(FAS,PTEN) 152 CP466722 ATM 4 45 2.77258872223978 NA 2.7392358521599 2.72933339698989 0.00990245517000954 1.60907703845055 1.02207351904244 0.00926143237721673 0.00615412123433508 0.00968859381004898 0.985912846734762 NA NA NA 0.991062176889228 99.9934512883142 a11416 loss_cnaBRCA29_(MAP2K4) 1192 GSK269962A ROCK1, ROCK2 7 39 1.6094379124341 NA 2.67704065421218 2.66631084034982 0.0107298138623571 1.1100264064734 1.5249545397722 0.0072731611145997 0.00966626901827146 0.00703615326392606 0.985943568923688 NA NA NA 0.982777545658502 99.9934512883142 a11417 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1046 681640 WEE1, CHEK1 3 33 0.693147180559945 NA 2.62332178959519 2.63474698305602 -0.0114251934608287 0.231722649174148 1.10899805900278 0.0106048742651889 0.0493054671243735 0.0103022664179433 0.986071767541879 NA NA NA 0.961847576680777 99.9934512883142 a11418 PIK3CA_mut 9 MG-132 Proteasome 4 10 0 NA 0.316919137777366 0.334018164695551 -0.0170990269181853 1.82921202173803 1.56618295858002 0.0104523040786114 0.00934775559912328 0.0109176433216258 0.986194371457502 NA NA NA 0.987534660123603 99.9934512883142 a11419 loss_cnaBRCA28_(GPS2) 292 Masitinib KIT 4 44 2.99573227355399 NA 4.00121412398255 4.01115585933656 -0.00994173535401099 0.717571306385572 1.11950094312025 0.00905619344706716 0.0138547002444786 0.00888050645701254 0.9862393446493 NA NA NA 0.981078707949435 99.9934512883142 a11420 loss_cnaBRCA17 1091 BMS-536924 IGF1R 9 38 1.38629436111989 NA 3.02896764576697 3.02196040763783 0.00700723812913351 0.933558806941309 1.13626716266039 0.00635314196124956 0.00750594186143652 0.00616689310349087 0.986402518834212 NA NA NA 0.984811916578323 99.9934512883142 a11421 loss_cnaBRCA38 253 XMD14-99 EPHB3, CAMK1 4 44 2.32630161961136 NA 4.92673058538051 4.93368104520865 -0.00695045982813713 0.360207951209574 0.800041128418066 0.00892270142102658 0.0192956868519909 0.00868762814966824 0.986442162067322 NA NA NA 0.975426227902802 99.9934512883142 a11422 gain_cnaBRCA8_(CHD4,WNK1) 1243 piperlongumine Increases ROS levels 3 44 2.30258509299405 NA 1.71845782338773 1.70968735558466 0.00877046780306467 0.855926427485607 0.860368138617301 0.0101961884299272 0.0102467543020363 0.0101938547110307 0.986442431763683 NA NA NA 0.987687593405565 99.9934512883142 a11423 ASH1L_mut 152 CP466722 ATM 3 46 2.77258872223978 NA 2.74008798958514 2.72949309357455 0.0105948960105899 0.732288437140339 1.0817562506369 0.00990904487967648 0.0144682006068047 0.00979416204376173 0.986802763008441 NA NA NA 0.982969969141599 99.9934512883142 a11424 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 34 Imatinib ABL, KIT, PDGFR 5 9 0.693147180559945 NA 2.77447022820923 2.77902949284835 -0.00455926463911682 0.656956038225003 0.375270559232849 0.00935051183755638 0.0069399843731329 0.0121492734427053 0.986900394002346 NA NA NA 0.989112604241196 99.9934512883142 a11425 loss_cnaBRCA42 211 TL-2-105 CRAF 3 46 2.32630161961136 1.63315443905142 3.91767326175196 3.90689376748279 0.0107794942691695 0.566059003826836 1.11411425633558 0.00983182532642507 0.0190430576959201 0.00967539389059085 0.986905597332427 NA NA NA 0.978269019991211 99.9934512883142 a11426 gain_cnaBRCA62 345 KIN001-270 CDK9 10 39 2.99573227355399 NA 5.11081106500731 5.10676030180982 0.00405076319748687 0.97049236394348 0.612445735480618 0.00582485356106449 0.00417392588338055 0.00661407690970046 0.986958442168101 NA NA NA 0.990195702781077 99.9934512883142 a11427 gain_cnaBRCA27_(CLTC,PPM1D) 110 Roscovitine CDKs 3 10 2.77258872223978 NA 4.07117066339596 4.08267995752028 -0.0115092941243171 1.08412909063874 1.05004165557776 0.010895638757654 0.0106161657534124 0.0109607976628169 0.98709068460262 NA NA NA 0.987992780347605 99.9934512883142 a11428 gain_cnaBRCA9_(KRAS) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 4 41 0.693147180559945 NA 0.636786505455566 0.624474524004499 0.0123119814510668 0.713246360371397 1.48789461981186 0.00850647231969242 0.01726189173213 0.00827476710186885 0.987118662783533 NA NA NA 0.977861241101836 99.9934512883142 a11429 loss_cnaBRCA25_(ARID1B,MAP3K4,MLLT4) 1194 SB-505124 TGFR1 (ALK5) 6 41 2.30258509299405 NA 4.39470296033615 4.38816437640244 0.00653858393370577 0.997752830165527 0.915707775975268 0.00706733922487395 0.00655331033500653 0.00714047003340328 0.987171297552068 NA NA NA 0.988384345884849 99.9934512883142 a11430 gain_cnaBRCA15 1529 MLN4924 NEDD8-activating enzyme 17 20 0 NA 0.364366724109032 0.373336538354323 -0.00896981424529009 1.8927680726938 1.55220777577978 0.00522625670177699 0.00473899278770282 0.00577874585171688 0.987449846791726 NA NA NA 0.987664605547937 99.9934512883142 a11431 loss_cnaBRCA20 328 SNX-2112 HSP90 3 45 0.940007258491471 NA 0.399343700519969 0.418433040508688 -0.0190893399887183 1.79689492940295 2.06632193050365 0.00928766973156334 0.0106235148624194 0.00923831843766254 0.98764009768769 NA NA NA 0.987303391341856 99.9934512883142 a11432 ASH1L_mut 1004 Vinblastine Microtubules 3 42 -2.30258509299405 NA -3.44433717514312 -3.45636201140079 0.0120248362576736 1.34996472708129 1.29090816217549 0.00929481261155356 0.00890751885323112 0.00931502070403589 0.987662787109811 NA NA NA 0.989285968427378 99.9934512883142 a11433 gain_cnaBRCA13_(FGFR1,WHSC1L1) 177 GSK-650394 SGK3 10 37 2.77258872223978 NA 4.0069869504284 4.01645282766739 -0.00946587723898507 1.73006325101199 1.70378635287054 0.00553859981725206 0.00547140529888028 0.00555578885993363 0.9876700429161 NA NA NA 0.987928175012866 99.9934512883142 a11434 loss_cnaBRCA28_(GPS2) 164 JQ12 HDAC 4 43 1.63315443905142 NA 1.56579326024111 1.57900781419749 -0.0132145539563822 0.874399338269506 1.6961972430244 0.00798867107034107 0.0151127218171672 0.00779069416055644 0.987874488531846 NA NA NA 0.980177452965959 99.9934512883142 a11435 gain_cnaBRCA15 150 Bicalutamide ANDR (androgen receptor) 22 26 0.0237165266173161 NA 2.76108950997672 2.76385547947084 -0.00276596949411978 0.663368566452743 0.597025226545246 0.00440313247210026 0.0041695817890654 0.00463291896412045 0.987938480798632 NA NA NA 0.988050730764352 99.9934512883142 a11436 gain_cnaBRCA15 1036 PLX4720 BRAF 20 23 2.30258509299405 NA 4.59364559318241 4.59919836279792 -0.00555276961550888 1.0061908055049 1.36585770934931 0.00457952582750472 0.00551860500526294 0.00406540855427334 0.988122070245448 NA NA NA 0.987869711511214 99.9934512883142 a11437 ARID1A_mut 341 EX-527 SIRT1 5 44 2.99573227355399 NA 5.64593046511246 5.64127855398307 0.00465191112939145 0.759320927790663 0.649342666486227 0.00705458173167725 0.00612640974209252 0.00716403121107724 0.988136899457152 NA NA NA 0.990039176690686 99.9934512883142 a11438 gain_cnaBRCA47_(EGFR) 1030 KU-55933 ATM 6 36 2.30258509299405 NA 4.21704744956751 4.22317467262795 -0.00612722306043967 0.992062005643524 0.921177284146692 0.00658605165494169 0.00617625009886867 0.00665151341211747 0.988157679347096 NA NA NA 0.989136207242835 99.9934512883142 a11439 loss_cnaBRCA17 32 VX-680 AURKA, AURKB, AURKC, FLT3, ABL1, JAK2 3 9 0.693147180559945 NA 1.17421618282991 1.19678292798973 -0.0225667451598157 1.72934486150109 2.34462989613953 0.0100962367536287 0.0130493030408218 0.00962486454556099 0.988214904433675 NA NA NA 0.98652250618381 99.9934512883142 a11440 gain_cnaBRCA9_(KRAS) 1527 GDC0941 (rescreen) PI3K 4 41 1.38629436111989 NA 0.972455060057413 0.98145591758861 -0.00900085753119739 1.2986065648023 1.15489878429687 0.00772274319633261 0.00693116589362668 0.00779363322014175 0.988305370074146 NA NA NA 0.990073229487656 99.9934512883142 a11441 loss_cnaBRCA36_(FAT1,IRF2) 1259 BMN-673 PARP1 9 37 2.30258509299405 NA 3.29867223800234 3.30720810056277 -0.00853586256042593 1.50996664461087 1.58219418988339 0.00543924844258698 0.00565301398603127 0.00539495253806681 0.988389820504522 NA NA NA 0.988214588394166 99.9934512883142 a11442 gain_cnaBRCA62 111 Salubrinal GADD34-PP1C 5 8 2.77258872223978 NA 3.24289643029766 3.23319828082988 0.00969814946778547 1.11209528904642 1.1682485697321 0.00844678381801954 0.0087206101521222 0.0083014434762025 0.988443786401424 NA NA NA 0.988359243561506 99.9934512883142 a11443 gain_cnaBRCA62 312 AV-951 VEGFR 10 38 -2.05572501506252 NA 0.634918667706287 0.631580369656472 0.00333829804981467 0.814438898835868 0.598559055190671 0.00516369684653741 0.00409889318227104 0.00557722420346853 0.988470877403127 NA NA NA 0.990527742381085 99.9934512883142 a11444 loss_cnaBRCA20 224 AS605240 PI3Kgamma 3 46 2.99573227355399 2.32630161961136 3.25733396007084 3.27109953992732 -0.0137655798564755 0.570911378860198 1.62296276134524 0.00864445579574028 0.0241115878334006 0.00848175952297607 0.988486860613032 NA NA NA 0.97445484115013 99.9934512883142 a11445 loss_cnaBRCA23 208 SB-715992 KIF11 3 46 -2.05572501506252 NA -1.22593987291356 -1.240809679914 0.0148698070004398 0.560363705031076 1.7545771818317 0.00864158412373732 0.0265359923687691 0.00847486628369145 0.988490684982476 NA NA NA 0.972682828697303 99.9934512883142 a11446 gain_cnaBRCA15 1025 SB 216763 GSK3A, GSK3B 18 21 2.30258509299405 NA 4.89114612076633 4.88746008679701 0.00368603396932343 0.879049648334127 0.714069268156858 0.00464154964583399 0.00419320339449402 0.00516201177350448 0.988548376260531 NA NA NA 0.988742199990317 99.9934512883142 a11447 loss_cnaBRCA42 173 FH535 unknown 3 45 3.46573590279973 NA 1.58337127692132 1.57230652308233 0.0110647538389881 1.17898323912189 1.29467086430303 0.00857828118002917 0.00938499672584754 0.00854638359761395 0.988584072859607 NA NA NA 0.98875905333617 99.9934512883142 a11448 gain_cnaBRCA48 1264 SGC0946 Q8TEK3 (DOT1L) 5 41 -0.693147180559945 NA 1.94712706205692 1.95115105371918 -0.00402399166225975 0.501288565828069 0.621736187624709 0.00657765272545413 0.00802729592607523 0.00647218505590462 0.988983912582754 NA NA NA 0.987427487743807 99.9934512883142 a11449 loss_cnaBRCA7_(FAS,PTEN) 225 Genentech Cpd 10 AURKA, AURKB 4 45 2.32630161961136 NA 3.02879104871692 3.0171098822805 0.0116811664364218 1.11193047336151 1.65495690660278 0.00718520878572944 0.0105053029090103 0.00705829039403834 0.989070664842701 NA NA NA 0.985538867516117 99.9934512883142 a11450 gain_cnaBRCA62 17 Cyclopamine SMO 5 8 2.77258872223978 NA 4.69981084359444 4.69303373616308 0.00677710743136473 0.543242810964782 0.983770222735072 0.00796926911077916 0.0124752823131314 0.00688891295420902 0.989097035995152 NA NA NA 0.987542832581987 99.9934512883142 a11451 gain_cnaBRCA19 173 FH535 unknown 4 44 3.46573590279973 NA 1.58141247083576 1.57223312468468 0.00917934615108162 1.34143772531608 1.28618119887153 0.00711656086339321 0.00684291635597075 0.00713689965234711 0.989186355177536 NA NA NA 0.990220678384055 99.9934512883142 a11452 loss_cnaBRCA29_(MAP2K4) 266 Zibotentan, ZD4054 Endothelin A Receptor 7 42 2.99573227355399 NA 5.74437209543061 5.74165059934839 0.00272149608221639 0.544478759201384 0.488630692963746 0.00548566602910965 0.00499835124185221 0.00556963801375104 0.989335959129069 NA NA NA 0.990408455609382 99.9934512883142 a11453 loss_cnaBRCA18 1161 ZG-10 IRAK1 7 19 2.30258509299405 NA 1.96920455912494 1.97769703178792 -0.00849247266298048 1.61728072871054 1.35111442168962 0.0059708037217001 0.00525108134427073 0.0062855318000087 0.989337092091775 NA NA NA 0.990376018829058 99.9934512883142 a11454 loss_cnaBRCA33 235 QL-XII-47 BTK, BMX 6 43 2.32630161961136 NA 1.71577377636743 1.70700086018618 0.00877291618125109 1.19471942920443 1.54909443348853 0.00578940709492294 0.00734307651386652 0.00566325460320366 0.98945702892351 NA NA NA 0.987502817170165 99.9934512883142 a11455 BRCA2_mut 1032 Afatinib ERBB2, EGFR 5 40 -0.693147180559945 NA 0.30078859245401 0.289182086637781 0.0116065058162286 2.10433146163496 1.81818427774644 0.00628508642607443 0.00551553119260545 0.00638356956348472 0.989489525745105 NA NA NA 0.991065760864932 99.9934512883142 a11456 gain_cnaBRCA13_(FGFR1,WHSC1L1) 11 Paclitaxel Microtubules 3 9 -2.27886856637673 NA -3.08174628459303 -3.09835688477629 0.0166106001832578 2.96670069849278 1.43949770027555 0.0089846303995773 0.00559901448491137 0.0115391640987534 0.989512364175637 NA NA NA 0.993290749708032 99.9934512883142 a11457 gain_cnaBRCA63 1013 Nilotinib ABL 6 34 0.693147180559945 NA 3.2077164262686 3.2020587276062 0.00565769866240284 1.82654883511111 0.755043096134202 0.00585398815632831 0.00309748009669759 0.00749321289257539 0.989521306566889 NA NA NA 0.994308590925856 99.9934512883142 a11458 loss_cnaBRCA20 1091 BMS-536924 IGF1R 3 44 1.38629436111989 NA 3.0152715915691 3.02384976198712 -0.00857817041801479 1.40125679740637 1.08709319226794 0.00777742363719269 0.00612176899615572 0.0078909246042822 0.98965837619323 NA NA NA 0.992586670531496 99.9934512883142 a11459 gain_cnaBRCA27_(CLTC,PPM1D) 1066 AZD6482 PI3Kbeta 9 34 1.6094379124341 NA 1.97272397817802 1.96572213616229 0.00700184201572385 1.5495965041579 1.42566841587868 0.00482658947945234 0.0045184936833146 0.00491126964568996 0.989789506292246 NA NA NA 0.990428399249987 99.9934512883142 a11460 loss_cnaBRCA20 185 OSI-906 IGF1R 3 45 0.940007258491471 NA 2.90165807560255 2.89294536839628 0.00871270720626427 1.23823257109062 1.13161554808309 0.00766653844667599 0.00703640609178149 0.00769935268300552 0.98979734246133 NA NA NA 0.991513663204968 99.9934512883142 a11461 loss_cnaBRCA60 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 3 44 2.77258872223978 NA 5.01827663417922 5.01039863169424 0.00787800248497827 0.932293056040235 1.03715099418033 0.00762842522292976 0.00845013532379918 0.0075958105706723 0.989856487929662 NA NA NA 0.989889958710354 99.9934512883142 a11462 loss_cnaBRCA28_(GPS2) 140 Vinorelbine Microtubules 4 43 -2.74887219562247 NA -3.58985151074614 -3.60074414875045 0.0108926380043077 1.91718151256078 1.63902816911015 0.0065656934374298 0.00568158931897816 0.00664579060298976 0.990034209901017 NA NA NA 0.991837578277377 99.9934512883142 a11463 NF1_mut 1050 ZM-447439 AURKB 4 35 1.38629436111989 0.693147180559945 2.88005857050346 2.88882299710829 -0.00876442660483256 1.66862509441703 1.29527018292226 0.00659250082487573 0.00525248399664912 0.00676648526337503 0.990101342317882 NA NA NA 0.99245628990266 99.9934512883142 a11464 gain_cnaBRCA14_(RAD21) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 20 25 2.30258509299405 NA 3.17956564544667 3.17470804443609 0.00485760101057897 0.806420682162457 1.60415030010176 0.00370000776218429 0.00602365628514521 0.00302814581044609 0.990216698554374 NA NA NA 0.989540240913136 99.9934512883142 a11465 loss_cnaBRCA38 294 MPS-1-IN-1 MPS1 4 45 2.99573227355399 NA 4.76341110857715 4.7559049557877 0.00750615278945332 1.3543585052044 1.16832710483451 0.00635534450531832 0.00554221999611579 0.00642470140288026 0.99033289355568 NA NA NA 0.992032838496331 99.9934512883142 a11466 gain_cnaBRCA63 1032 Afatinib ERBB2, EGFR 6 39 -0.693147180559945 NA 0.298971541731755 0.289164030189507 0.00980751154224796 2.44890393096067 1.75209091984893 0.00531090389582312 0.0040048576092573 0.00559760422883398 0.990393292396371 NA NA NA 0.992779813487966 99.9934512883142 a11467 BRCA1_mut 1020 Lenalidomide TNFA 4 41 1.6094379124341 NA 4.25063580223775 4.25512567684965 -0.00448987461189354 0.7565654019555 0.712926624513888 0.00627027108660158 0.00593454921450086 0.00629780745662989 0.99050474367479 NA NA NA 0.991527482932664 99.9934512883142 a11468 gain_cnaBRCA13_(FGFR1,WHSC1L1) 135 Gemcitabine DNA replication 10 37 0.0237165266173161 NA -0.266370847439429 -0.27761640062531 0.0112455531858804 2.89035047674142 2.75778972658552 0.00403818084384667 0.00389072303735244 0.0040777413439 0.991010082385663 NA NA NA 0.991363991911541 99.9934512883142 a11469 loss_cnaBRCA29_(MAP2K4) 1039 SL 0101-1 RSK, AURKB, PIM3 5 38 2.30258509299405 NA 4.64419475332972 4.64943804413294 -0.00524329080321451 1.02240469509598 0.96693644656453 0.00539162926145606 0.0051283907716428 0.00542258058618394 0.991012368512225 NA NA NA 0.991765937901819 99.9934512883142 a11470 NF1_mut 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 4 39 -1.38629436111989 0.693147180559945 -2.21535298850705 -2.22104019241548 0.00568720390842659 0.680665049908944 0.979241282391837 0.00592080062224765 0.00835536349220133 0.00580776567602967 0.991056834556936 NA NA NA 0.988555375525061 99.9934512883142 a11471 loss_cnaBRCA60 288 KIN001-055 JAK3, MNK1 3 46 2.32630161961136 NA 4.33359957622709 4.33935964702075 -0.00576007079366292 1.21860334294076 0.842225168736723 0.00668534102056208 0.00472678072568107 0.00683911026109872 0.991095984184191 NA NA NA 0.99426025474594 99.9934512883142 a11472 gain_cnaBRCA47_(EGFR) 302 PI-103 PI3Ka, PRKDC (DNAPK) 7 41 2.32630161961136 NA 1.13575464263268 1.12718315007314 0.00857149255954615 1.13347190109852 1.95456224118285 0.00458848497091299 0.00756215707794697 0.0043853771340425 0.991096509811358 NA NA NA 0.987244465625745 99.9934512883142 a11473 BRCA1_mut 1066 AZD6482 PI3Kbeta 4 39 1.6094379124341 NA 1.9748370300026 1.96640308495153 0.00843394505106732 0.857834631485647 1.48745587215207 0.00581377999359788 0.00983166771486123 0.00567004723230206 0.991218478700277 NA NA NA 0.98693719660607 99.9934512883142 a11474 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 6 PHA-665752 MET 3 11 0.693147180559945 NA 2.86886433857814 2.86317341606257 0.00569092251556791 0.56237671548599 0.820056560068241 0.00726790529134676 0.0101194134800727 0.00693967074063079 0.991280429478632 NA NA NA 0.989449342329803 99.9934512883142 a11475 loss_cnaBRCA28_(GPS2) 1194 SB-505124 TGFR1 (ALK5) 4 43 2.30258509299405 NA 4.38417880181357 4.38944748807588 -0.00526868626230925 1.36941741952612 0.884961564516267 0.00569473977926577 0.00384739246571908 0.00595357637389505 0.991356136303716 NA NA NA 0.994417857404635 99.9934512883142 a11476 gain_cnaBRCA62 94 TGX221 PI3Kbeta 5 9 2.30258509299405 NA 3.77429067053109 3.76632274587921 0.00796792465187979 1.43906297994547 1.25078719513479 0.0060521666430208 0.00553688390495719 0.00637032796855672 0.991520962990604 NA NA NA 0.991983693026218 99.9934512883142 a11477 gain_cnaBRCA48 176 IPA-3 PAK1, PAK2, PAK3 5 42 3.46573590279973 NA 4.50360992270081 4.49603344134924 0.00757648135157662 2.06418365837975 1.45736817646392 0.00498078662942463 0.00367044924555001 0.00519874213938154 0.99164631745529 NA NA NA 0.993979750844546 99.9934512883142 a11478 ARID1A_mut 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 5 43 2.07944154167984 NA 3.21941984334971 3.21370852145191 0.00571132189780021 1.20309000218587 1.16666584290589 0.00488198001087585 0.00474721083827761 0.00489542222610603 0.99180089092069 NA NA NA 0.992354857911821 99.9934512883142 a11479 MACF1_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 43 1.38629436111989 NA 2.85013422819532 2.85920052413927 -0.00906629594394692 1.25261206419534 1.50354514311117 0.00607231496106128 0.00723791204244146 0.00602994594840479 0.991932568887007 NA NA NA 0.991379218033853 99.9934512883142 a11480 loss_cnaBRCA28_(GPS2) 257 NPK76-II-72-1 PLK3 4 45 2.32630161961136 NA 3.4867022015093 3.47827212778483 0.00843007372447513 1.57468376119761 1.59796626917227 0.00528037893079799 0.00535350267285651 0.0052755016717855 0.99196795950761 NA NA NA 0.992369515127679 99.9934512883142 a11481 PIK3CA_mut 305 TPCA-1 IKK 17 32 2.99573227355399 NA 4.17561642179926 4.1797660233338 -0.00414960153454302 1.32589223770775 1.42379159223988 0.00298266879888688 0.00312966726595896 0.00291447256547916 0.992112682952063 NA NA NA 0.991950340406383 99.9934512883142 a11482 loss_cnaBRCA28_(GPS2) 269 NSC-207895 MDM4 4 45 2.99573227355399 NA 4.60962509292733 4.60343727118989 0.00618782173744048 0.916907622016555 1.21349203580713 0.0051704820202567 0.00674857705275871 0.00509918611317854 0.99213511921786 NA NA NA 0.990583930064746 99.9934512883142 a11483 CDH1_mut 134 Etoposide TOP2 4 43 2.77258872223978 NA 2.4668545489226 2.47805491998637 -0.0112003710637709 2.65629233857832 2.13735669170502 0.00514768743544859 0.00421654307438371 0.00524029101330584 0.992186460695957 NA NA NA 0.993926375353702 99.9934512883142 a11484 loss_cnaBRCA23 310 YM201636 FYV1 3 46 1.63315443905142 NA 2.40908662447792 2.41503145288563 -0.00594482840770594 1.53965599337017 0.995495266482179 0.00580234814909565 0.00386114069201475 0.00597172945755273 0.992271976460938 NA NA NA 0.995306350257525 99.9934512883142 a11485 ARID1A_mut 260 NG-25 MAP3K7 (TAK1) 5 44 2.32630161961136 NA 3.20306172985135 3.20894359499623 -0.00588186514488109 1.31138810517642 1.29320486381426 0.00454281459633694 0.00448522075323371 0.00454828566568543 0.992360558277708 NA NA NA 0.992779789911445 99.9934512883142 a11486 gain_cnaBRCA62 119 Lapatinib ERBB2, EGFR 5 8 0.693147180559945 NA 1.45019926195935 1.43725204634863 0.0129472156107246 2.43395514276403 2.25774698400225 0.00557260306373283 0.00531941422553155 0.00573457331687959 0.992375838621888 NA NA NA 0.992578490686674 99.9934512883142 a11487 ARID1A_mut 152 CP466722 ATM 5 44 2.77258872223978 NA 2.72588276043262 2.73062573797776 -0.00474297754514641 0.659427640113505 1.0996000854102 0.0044359362491666 0.00719256709398778 0.00431336593010274 0.992540285192603 NA NA NA 0.989212909304083 99.9934512883142 a11488 loss_cnaBRCA28_(GPS2) 1032 Afatinib ERBB2, EGFR 3 42 -0.693147180559945 NA 0.30011709329651 0.28978274161647 0.0103343516800398 2.22584789898634 1.82616694524109 0.00559619131933998 0.00464288313893601 0.00565903993989744 0.992571854610697 NA NA NA 0.994388469673223 99.9934512883142 a11489 gain_cnaBRCA13_(FGFR1,WHSC1L1) 1021 Axitinib PDGFR, KIT, VEGFR 8 37 0.693147180559945 NA 2.46578986428313 2.46160850848011 0.00418135580301993 1.66732454386505 1.05937315768502 0.00354386602688035 0.0025078235778423 0.00394700939200419 0.992790152206381 NA NA NA 0.994733788629927 99.9934512883142 a11490 NF1_mut 310 YM201636 FYV1 5 44 1.63315443905142 NA 2.41848980876137 2.41423312869013 0.00425668007124491 1.34403409406511 0.989607344060135 0.00415465905628741 0.00316709233050059 0.00430138286340996 0.993013283516324 NA NA NA 0.994809677062015 99.9934512883142 a11491 ASH1L_mut 275 I-BET BRD2, BRD3, BRD4 3 46 2.99573227355399 NA 4.04552856390621 4.03851143946823 0.00701712443797398 0.613251299040655 1.39348763117293 0.0051243358735894 0.0114424942090645 0.00503565606252816 0.993174982287603 NA NA NA 0.98724126066212 99.9934512883142 a11492 POLR2B_mut 1268 XAV 939 TNKS1 (tankyrase-1) 3 44 1.6094379124341 NA 3.66598953642368 3.6611326732229 0.00485686320077461 1.25775035640689 0.929540749690431 0.00513113504571579 0.00386154786284425 0.00522501375264302 0.993177029033389 NA NA NA 0.995318763270329 99.9934512883142 a11493 gain_cnaBRCA31 30 Sorafenib PDGFRA, PDGFRB, KDR, KIT, FLT3 4 10 1.38629436111989 NA 1.91756373419132 1.92179163777102 -0.00422790357969971 0.943737605549279 0.784815630694657 0.0051097878468315 0.00447995666892914 0.00538712968287533 0.993250592597194 NA NA NA 0.993993894389104 99.9934512883142 a11494 NF1_mut 158 PF-562271 FAK 4 41 0.940007258491471 NA 2.32802436090666 2.33376004405588 -0.00573568314921946 1.43878775876772 1.2882831430238 0.00441427350615994 0.00398646924417254 0.00445219141481345 0.993315253127411 NA NA NA 0.994292483666417 99.9934512883142 a11495 loss_cnaBRCA29_(MAP2K4) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 7 42 1.63315443905142 NA 3.57376799205204 3.57713838255048 -0.0033703904984419 0.848294982005424 1.02861324952154 0.00334565713963367 0.0039731350178143 0.00327663531459434 0.993495974250892 NA NA NA 0.992684092146922 99.9934512883142 a11496 loss_cnaBRCA29_(MAP2K4) 345 KIN001-270 CDK9 7 42 2.99573227355399 NA 5.10955849900244 5.10725840303902 0.00230009596341318 0.88775253635708 0.66261827139398 0.00330744908446195 0.00259092018238743 0.00347122327094055 0.993570249820583 NA NA NA 0.994947146448409 99.9934512883142 a11497 gain_cnaBRCA8_(CHD4,WNK1) 1053 MK-2206 AKT1, AKT2 3 39 1.38629436111989 0.693147180559945 1.40122223768676 1.3933141924724 0.00790804521435651 1.69789742688077 1.65705255311315 0.00476641322712232 0.00465755179857035 0.00477235631392587 0.993692151052699 NA NA NA 0.994410056123251 99.9934512883142 a11498 loss_cnaBRCA24 300 CX-5461 RNA Pol I 3 46 2.32630161961136 NA 3.90478300619766 3.91285979020368 -0.00807678400602541 1.50214114241282 1.72975486453917 0.00469394170562874 0.00537684760637876 0.0046693229032642 0.993748204456611 NA NA NA 0.993570530041435 99.9934512883142 a11499 gain_cnaBRCA14_(RAD21) 291 KIN001-266 MAP3K8 (COT) 21 28 2.99573227355399 NA 3.77709403563301 3.77978968895835 -0.00269565332533706 1.36412011458637 1.0397756060562 0.00226780546900002 0.00197611141168051 0.00259253372519623 0.993765207305659 NA NA NA 0.99401155251275 99.9934512883142 a11500 loss_cnaBRCA34 1166 QL-VIII-58 MTOR, ATR 3 23 2.30258509299405 NA -1.51420874682761 -1.51965555089826 0.0054468040706448 0.877512044141786 1.15905274699856 0.00478522767041873 0.00620709893044467 0.00469935823434234 0.993844641363063 NA NA NA 0.992867120843236 99.9934512883142 a11501 gain_cnaBRCA14_(RAD21) 1013 Nilotinib ABL 17 23 0.693147180559945 NA 3.20156434524972 3.20390006204249 -0.00233571679276334 1.09582687527791 0.860261615812448 0.00241674894428721 0.00213146514787839 0.0027151238063289 0.994010799256812 NA NA NA 0.994237043257077 99.9934512883142 a11502 CDH1_mut 255 CP724714 ERBB2 4 44 2.32630161961136 NA 3.80906792960593 3.80248729936628 0.00658063023964495 1.36449631967795 1.70113834684052 0.00391415418379508 0.00482275411427868 0.00386836864377725 0.994052294709849 NA NA NA 0.993238878321229 99.9934512883142 a11503 gain_cnaBRCA63 157 JNK-9L JNK 6 41 1.63315443905142 NA 0.0528870798370147 0.0562770614341609 -0.00338998159714621 1.08409924865948 1.06139112053994 0.00318625805458243 0.00312700299473322 0.00319390423713146 0.994216068350993 NA NA NA 0.994492459919583 99.9934512883142 a11504 PTEN_mut 328 SNX-2112 HSP90 9 39 0.940007258491471 NA 0.412751346005374 0.41827579001032 -0.00552444400494623 1.89353731709069 2.08781423109567 0.00268784072982881 0.00291752581535294 0.00264604193355222 0.994232169165681 NA NA NA 0.993947043603052 99.9934512883142 a11505 gain_cnaBRCA19 1023 GW 441756 NTRK1 4 41 0.693147180559945 NA 2.36383494097294 2.35884306893586 0.00499187203708074 0.703562651674096 1.34684217006398 0.00380409799688644 0.00709513506039981 0.00370635264326747 0.994239253320095 NA NA NA 0.990714104161339 99.9934512883142 a11506 loss_cnaBRCA7_(FAS,PTEN) 1038 NU-7441 PRKDC (DNAPK) 4 39 0.693147180559945 NA 2.89612396545765 2.89253076441293 0.00359320104471106 0.585460139508426 0.97596997079233 0.00377104929823996 0.00613739655739509 0.00368167172376621 0.994303886391953 NA NA NA 0.991785586485216 99.9934512883142 a11507 gain_cnaBRCA62 56 WH-4-023 SRC family, ABL 4 8 1.63315443905142 NA 3.22672166073682 3.2215656320521 0.00515602868471188 0.734694704412718 1.30348757528035 0.00443548624939279 0.00701792003364633 0.00395556412081868 0.994363337778416 NA NA NA 0.993198007075338 99.9934512883142 a11508 loss_cnaBRCA22_(SYNCRIP,ZNF292) 287 KIN001-244 PDPK1 (PDK1) 19 30 2.99573227355399 NA 3.47690051378004 3.47886954297271 -0.00196902919266817 0.83540355693878 1.0142878036685 0.00207316831320128 0.00235697966128299 0.00194129238816295 0.994388222894771 NA NA NA 0.994138630010528 99.9934512883142 a11509 NF1_mut 197 Bryostatin 1 PRKC 5 43 -4.8283137373023 NA -2.80393729168056 -2.80713725232429 0.00319996064372186 0.598040025197358 1.0022136637619 0.0032862216065666 0.00535074662045545 0.00319289265296034 0.994480854646892 NA NA NA 0.992002793605066 99.9934512883142 a11510 gain_cnaBRCA31 1166 QL-VIII-58 MTOR, ATR 10 16 2.30258509299405 NA -1.52097813753554 -1.5178076584867 -0.00317047904884071 1.04362554495837 1.19142925639577 0.00278538749685327 0.00303794695727498 0.00266107201230883 0.994544019540295 NA NA NA 0.994376466797794 99.9934512883142 a11511 gain_cnaBRCA14_(RAD21) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 21 27 2.32630161961136 NA 4.95927856323985 4.95787739032844 0.00140117291141451 0.834330879571442 0.578160698632308 0.0019984343086811 0.00167939716211178 0.00242350079265005 0.994549488629479 NA NA NA 0.994798824132407 99.9934512883142 a11512 BRCA1_mut 231 FMK RSK 4 45 2.99573227355399 2.32630161961136 5.59109554031493 5.58906384466106 0.0020316956538684 0.806257276062208 0.580885306495673 0.00339853752522131 0.00251990985283418 0.00349758486081372 0.994830395671108 NA NA NA 0.996352884713843 99.9934512883142 a11513 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 39 2.30258509299405 NA 3.18011068749342 3.17636794602244 0.00374274147098452 0.919763523618502 1.35613123399706 0.00285082178954114 0.00406924320749311 0.00275986672761246 0.994843156729688 NA NA NA 0.993308488025071 99.9934512883142 a11514 gain_cnaBRCA5_(GATA3,KLF6,LARP4B,VIM) 1371 PLX4720 (rescreen) BRAF 6 41 2.30258509299405 NA 4.70950921882758 4.70680170352709 0.00270751530048852 0.654383516762108 0.995760068683715 0.00280915342310467 0.00413750534837019 0.00271904385969961 0.994900606332011 NA NA NA 0.993206094735079 99.9934512883142 a11515 gain_cnaBRCA10_(MDM2,NUP107) 197 Bryostatin 1 PRKC 4 44 -4.8283137373023 NA -2.80393443248996 -2.80706478587244 0.00313035338247536 0.701523074295314 0.989953805828668 0.00321473758442015 0.00446222440454981 0.00316212066062518 0.995115069471964 NA NA NA 0.99382534518852 99.9934512883142 a11516 POLR2B_mut 300 CX-5461 RNA Pol I 3 46 2.32630161961136 NA 3.9182111747195 3.91198404008269 0.00622713463680391 0.772037533023596 1.75095644811461 0.00361898982698338 0.00806584443170276 0.00355641891807711 0.995179897235703 NA NA NA 0.991002883215199 99.9934512883142 a11517 MLL3_mut 290 KIN001-260 IKK 3 46 2.99573227355399 NA 5.04756109925538 5.04384619169133 0.00371490756404924 0.91096722219241 1.05539646698985 0.00353916853352546 0.0040779815931342 0.00351991661924426 0.995286209268377 NA NA NA 0.995125076344968 99.9934512883142 a11518 loss_cnaBRCA57 1021 Axitinib PDGFR, KIT, VEGFR 5 40 0.693147180559945 NA 2.4652886451572 2.46198476255608 0.00330388260111958 0.820284525754633 1.21074432668585 0.00280017089096895 0.00402772757182043 0.00272880287629614 0.995317195602895 NA NA NA 0.993871527569316 99.9934512883142 a11519 loss_cnaBRCA29_(MAP2K4) 1052 RO-3306 CDK1 5 38 1.6094379124341 NA 3.52276078923822 3.52605659373327 -0.00329580449504929 1.01123986213933 1.23114553056755 0.00272054557705199 0.00325917185273615 0.00267702266971635 0.995464884620799 NA NA NA 0.994908455739868 99.9934512883142 a11520 gain_cnaBRCA12_(TERT) 1043 JNK Inhibitor VIII JNK 9 34 2.30258509299405 NA 4.79852519760391 4.79701511800449 0.00151007959942362 0.682857088306386 0.768219132669133 0.00200721958941947 0.0022114138159844 0.00196568861045798 0.995753692574588 NA NA NA 0.995500448660927 99.9934512883142 a11521 gain_cnaBRCA15 1203 QL-XII-61 BTK 12 11 2.30258509299405 NA 4.22685378689983 4.22341894843682 0.00343483846300963 1.61111838654662 1.44671367874131 0.00223763892931191 0.00213195907370413 0.00237423514651362 0.995773482073025 NA NA NA 0.995752808670081 99.9934512883142 a11522 gain_cnaBRCA64_(SDHC) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 8 40 2.32630161961136 NA 4.95730145453518 4.95872819326558 -0.00142673873039723 1.02923890404421 0.624250433211281 0.00203489733393595 0.00138620754111714 0.00228552301206708 0.995830588279748 NA NA NA 0.997072749668064 99.9934512883142 a11523 MACF1_mut 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 3 40 1.6094379124341 NA 2.8639405052057 2.86826033880405 -0.0043198335983532 0.708513064811381 1.46707517807234 0.00300118281874009 0.00609704155491221 0.00294452095088216 0.996024065970783 NA NA NA 0.993173213185926 99.9934512883142 a11524 BRCA2_mut 179 5-Fluorouracil DNA antimetabolite 6 43 3.46573590279973 NA 4.04448658313483 4.04105670269383 0.00342988044099712 1.23818724634135 1.67082457913265 0.00210387797444666 0.00277008219163289 0.00205280702943551 0.996168570878968 NA NA NA 0.995317619432305 99.9934512883142 a11525 loss_cnaBRCA33 1006 Cytarabine DNA synthesis 5 40 0.693147180559945 NA 1.20546036674692 1.20891738829986 -0.00345702155293703 1.88571640871096 1.50097297440939 0.00224362287689408 0.0018332669413956 0.00230318707390272 0.996247918488923 NA NA NA 0.997014968012614 99.9934512883142 a11526 gain_cnaBRCA48 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 4 39 -1.38629436111989 0.693147180559945 -2.21835662799758 -2.2207321268267 0.00237549882912047 0.665321292112574 0.980074741006394 0.0024730671106206 0.00357045363989122 0.00242379354321608 0.996264450335904 NA NA NA 0.995125407997976 99.9934512883142 a11527 loss_cnaBRCA34 256 JW-7-24-1 LCK 5 43 2.32630161961136 NA 1.83527943638958 1.83783537192457 -0.00255593553498756 0.587970709336966 1.21372938506698 0.00217962856244813 0.0043470456850985 0.0021058528914553 0.996339339280455 NA NA NA 0.993836479312443 99.9934512883142 a11528 loss_cnaBRCA17 11 Paclitaxel Microtubules 3 9 -2.27886856637673 NA -3.08989171976808 -3.09564173971794 0.00575001994985769 0.714292703267531 2.03592648997719 0.00311014596299691 0.0080499491644731 0.00282427679887505 0.996369462877579 NA NA NA 0.994369437825542 99.9934512883142 a11529 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 6 40 2.30258509299405 NA 1.4114690830603 1.41343079011899 -0.00196170705869636 0.403419828957429 1.05556840381886 0.0019557488924876 0.004862693694968 0.00185843669780116 0.996455858831321 NA NA NA 0.993416318358554 99.9934512883142 a11530 gain_cnaBRCA27_(CLTC,PPM1D) 1018 ABT-888 PARP1, PARP2 10 35 1.6094379124341 NA 4.4022489135122 4.40331255731043 -0.00106364379822921 0.597223430437924 0.687693710712665 0.00158807311321072 0.00178098136144671 0.00154668245711734 0.996486725152362 NA NA NA 0.996230711897906 99.9934512883142 a11531 loss_cnaBRCA7_(FAS,PTEN) 305 TPCA-1 IKK 4 45 2.99573227355399 NA 4.18126630102181 4.17806503807071 0.00320126295110246 0.653359831668112 1.42772878577056 0.00230101588909985 0.00489969354701409 0.00224220663126485 0.996499850850805 NA NA NA 0.993714586633626 99.9934512883142 a11532 gain_cnaBRCA15 6 PHA-665752 MET 6 8 0.693147180559945 NA 2.86547285627738 2.8635829318448 0.00188992443257607 1.06227780092072 0.495026149284257 0.00241362132725613 0.00177912447284317 0.00381782747297018 0.996507577193439 NA NA NA 0.996894345552002 99.9934512883142 a11533 BRCA1_mut 1239 YK 4-279 RNA helicase A 4 38 2.30258509299405 NA 2.01084590232803 2.01383782518319 -0.00299192285516181 0.491764614014027 1.35053684393609 0.00229113745714986 0.00608405478942507 0.0022153581878166 0.996544006727878 NA NA NA 0.992945638012322 99.9934512883142 a11534 gain_cnaBRCA48 271 VNLG/124 HDAC, RAR 5 44 1.63315443905142 NA 4.15292612716714 4.15127123954699 0.00165488762014654 0.715267234839727 0.828244552731082 0.002020037102266 0.00231366339675458 0.00199806641008342 0.996602953818371 NA NA NA 0.996330895860058 99.9934512883142 a11535 gain_cnaBRCA27_(CLTC,PPM1D) 154 CHIR-99021 GSK3B 9 38 0.940007258491471 NA 3.27428718598201 3.27570915029489 -0.00142196431288566 0.898654505467484 0.916088587452991 0.00155744057665464 0.00158232591528148 0.00155221267065357 0.996666489585398 NA NA NA 0.99667546445826 99.9934512883142 a11536 loss_cnaBRCA29_(MAP2K4) 196 Phenformin AAPK1 (AMPK) agonist 6 42 8.29404964010203 NA 7.19908716552609 7.20243107241107 -0.00334390688497432 1.85392021493483 1.82179934880029 0.00183195840405239 0.00180369514180624 0.00183549680549419 0.996669005555936 NA NA NA 0.996820394663469 99.9934512883142 a11537 gain_cnaBRCA39_(FOXA1,NKX2-1,PSMA6) 1378 Bleomycin (50 uM) DNA damage 6 42 3.91202300542815 NA 3.81573066111322 3.81228717775027 0.00344348336294287 2.06167868920137 1.87968767804788 0.00181206041718024 0.00167023279669092 0.00183194442521379 0.996705185248824 NA NA NA 0.997034364862667 99.9934512883142 a11538 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 170 Shikonin unknown 9 38 2.77258872223978 NA 0.00217706511527944 0.00394691442539251 -0.00176984931011307 0.890394299795007 1.25214942540333 0.00147997739545308 0.00198771410657115 0.00141344896560008 0.996832289093961 NA NA NA 0.996132734960218 99.9934512883142 a11539 gain_cnaBRCA62 1241 CHIR-99021 GSK3B 8 38 2.30258509299405 NA 4.232726475176 4.23122616981556 0.00150030536043211 1.26601562129523 0.922779339948288 0.00152251132194878 0.0011850607016185 0.00162585495305539 0.996894797234253 NA NA NA 0.997535927753057 99.9934512883142 a11540 MACF1_mut 1001 AICAR AAPK1 (AMPK) agonist 3 42 7.60090245954208 NA 7.74145135664861 7.73827129134623 0.00318006530237813 0.977327813976389 1.40907055062957 0.00228459191748913 0.0032538368978159 0.00225685314405108 0.996967492453644 NA NA NA 0.996176211592111 99.9934512883142 a11541 loss_cnaBRCA28_(GPS2) 301 PHA-793887 CDK-pan 4 44 2.32630161961136 NA 2.92516701123315 2.92200653295691 0.00316047827623356 0.537469557908393 1.70502646166242 0.00191058412912593 0.00588029262258651 0.00185362417962244 0.997096774014668 NA NA NA 0.993379931253008 99.9934512883142 a11542 gain_cnaBRCA8_(CHD4,WNK1) 164 JQ12 HDAC 3 44 1.63315443905142 NA 1.57459234745357 1.57810754566127 -0.00351519820769974 1.92876643063155 1.64027522316326 0.00212505797823332 0.00182251108888738 0.00214305389611428 0.997174239210642 NA NA NA 0.997797980421738 99.9934512883142 a11543 gain_cnaBRCA10_(MDM2,NUP107) 1243 piperlongumine Increases ROS levels 3 44 2.30258509299405 NA 1.71193362935522 1.71013218699597 0.00180144235925495 0.78464682760116 0.863526020530675 0.00209427696197203 0.00229586394271466 0.00208614716456127 0.99721516958616 NA NA NA 0.997251643810422 99.9934512883142 a11544 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 8 39 2.99573227355399 NA 3.84927783593879 3.84733098014799 0.00194685579080867 1.44828365013589 1.4368794118374 0.00135324307433488 0.00134425034117177 0.0013549194001737 0.997233499235767 NA NA NA 0.997300842177273 99.9934512883142 a11545 gain_cnaBRCA48 1243 piperlongumine Increases ROS levels 5 42 2.30258509299405 NA 1.70909261971772 1.71038461945952 -0.00129199974179373 0.826067847869216 0.863429205036257 0.00150202154009129 0.00156403586597196 0.00149635862935569 0.997480794207673 NA NA NA 0.997499880329174 99.9934512883142 a11546 ASH1L_mut 256 JW-7-24-1 LCK 3 45 2.32630161961136 NA 1.83962784074464 1.83743188116601 0.00219595957862451 0.609920357328309 1.19193012952943 0.00187265115261092 0.00360040381049696 0.00184235596048861 0.997507802996213 NA NA NA 0.99589291451972 99.9934512883142 a11547 loss_cnaBRCA7_(FAS,PTEN) 1021 Axitinib PDGFR, KIT, VEGFR 4 41 0.693147180559945 NA 2.46060379666015 2.4625224034485 -0.00191860678835809 0.922327329843003 1.19697128161757 0.00162609449353715 0.00208017991691157 0.00160288456191306 0.997537501052348 NA NA NA 0.997105741841298 99.9934512883142 a11548 POLR2B_mut 326 GSK690693 AKT 3 45 2.32630161961136 NA 2.93637039872177 2.93979210729521 -0.00342170857344515 0.846221185324166 1.97989944313019 0.00175977374683598 0.00404351561126938 0.00172822341322318 0.997658024179072 NA NA NA 0.995525810679402 99.9934512883142 a11549 loss_cnaBRCA17 173 FH535 unknown 11 37 3.46573590279973 NA 1.57399652184694 1.57270123322034 0.00129528862660222 0.881078438647786 1.38211731063742 0.00100420906300164 0.00147011726741394 0.000937177051928279 0.997679508182716 NA NA NA 0.997071739229394 99.9934512883142 a11550 gain_cnaBRCA14_(RAD21) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 19 23 1.38629436111989 0.693147180559945 3.43389640575401 3.4330443246245 0.000852081129505411 1.10175290827288 1.01196147288615 0.00080895164772407 0.000773386775843543 0.000842009456224895 0.997930982635431 NA NA NA 0.997949049722789 99.9934512883142 a11551 loss_cnaBRCA20 257 NPK76-II-72-1 PLK3 3 46 2.32630161961136 NA 3.48123490858601 3.47881195283905 0.00242295574695506 1.84839720590121 1.58436681774957 0.00151767491444654 0.00131084148970768 0.00152928963154922 0.997978610813627 NA NA NA 0.998415581716618 99.9934512883142 a11552 PIK3CA_mut 256 JW-7-24-1 LCK 16 32 2.32630161961136 NA 1.83700109109202 1.8378531474135 -0.000852056321482442 1.55198987854608 0.935407619245052 0.000726609084547148 0.000549008942172132 0.000910893073727707 0.998116807482579 NA NA NA 0.998407522956475 99.9934512883142 a11553 loss_cnaBRCA23 287 KIN001-244 PDPK1 (PDK1) 3 46 2.99573227355399 NA 3.47684815169809 3.47818807817191 -0.00133992647382097 0.187940219313071 0.969836109369279 0.0014107925905896 0.00712953554443247 0.00138160093326735 0.998120966955717 NA NA NA 0.994155693037691 99.9934512883142 a11554 loss_cnaBRCA32_(PABPC3,SACS,ZMYM2) 1170 CCT018159 HSP90 6 37 2.30258509299405 NA 3.34177958599622 3.34299848986648 -0.0012189038702668 0.95549934554853 1.23165719718717 0.00101458400618737 0.00127567211421485 0.000989645392444015 0.998171806906248 NA NA NA 0.997855275373475 99.9934512883142 a11555 loss_cnaBRCA57 140 Vinorelbine Microtubules 5 42 -2.74887219562247 NA -3.59824126424025 -3.60000471709649 0.00176345285624224 1.21450233743781 1.69616836271505 0.00106294464161478 0.00145199626372275 0.00103966852289326 0.998217216915812 NA NA NA 0.997760466906587 99.9934512883142 a11556 gain_cnaBRCA64_(SDHC) 298 OSI-930 KIT, VEGFR, PDGFR 8 40 2.32630161961136 NA 3.91399335533825 3.91324208466302 0.000751270675226845 0.906325385559945 0.8757844312048 0.000853231588172304 0.000828919378400391 0.000857826022544539 0.998251760662471 NA NA NA 0.99832600294253 99.9934512883142 a11557 loss_cnaBRCA22_(SYNCRIP,ZNF292) 5 Sunitinib PDGFRA, PDGFRB, KDR, KIT, FLT3 3 9 2.07944154167984 NA 3.2539160509785 3.25589963800252 -0.00198358702402057 1.65117516627235 1.38687823517126 0.00137404268989714 0.0012013183486151 0.00143025319290243 0.998396046657456 NA NA NA 0.998623372838632 99.9934512883142 a11558 loss_cnaBRCA36_(FAT1,IRF2) 1143 HG-5-88-01 EGFR, ADCK4 3 23 2.30258509299405 NA 4.5351004594019 4.53394355881973 0.00115690058216966 0.721804591250748 1.01361670417698 0.00116554756318013 0.0016027891706327 0.00114135903384606 0.998500711992416 NA NA NA 0.9981733897135 99.9934512883142 a11559 TP53_mut 1021 Axitinib PDGFR, KIT, VEGFR 35 10 0.693147180559945 NA 2.46252320899407 2.46175214132368 0.000771067670388703 1.1885829812314 1.14643790114727 0.000653510040986242 0.000648728513334306 0.000672576918136673 0.998554243661383 NA NA NA 0.998540196762448 99.9934512883142 a11560 ASH1L_mut 221 TAK-715 p38a 3 46 2.99573227355399 2.32630161961136 4.48114176473898 4.48221864536235 -0.00107688062337719 0.804157007343943 1.02244250093379 0.00106189582839715 0.0013391422490168 0.00105324321161696 0.998585661570915 NA NA NA 0.998407137649078 99.9934512883142 a11561 BRCA1_mut 1016 Temsirolimus MTOR 4 40 -1.6094379124341 NA -1.7497662009717 -1.75105843492965 0.00129223395794664 1.03458031779336 1.54147951715726 0.000855261447899661 0.00124904169905613 0.000838307576301585 0.998706437040219 NA NA NA 0.99829440352617 99.9934512883142 a11562 MLL3_mut 1164 XMD8-92 MAP2K5 (ERK5) 3 23 2.30258509299405 NA 3.88348834773103 3.88461950487908 -0.00113115714805145 1.27757637632249 1.32506689183523 0.00085617539850685 0.000885392974553503 0.000853660411426318 0.99889866881641 NA NA NA 0.998957201170822 99.9934512883142 a11563 gain_cnaBRCA9_(KRAS) 1020 Lenalidomide TNFA 4 41 1.6094379124341 NA 4.2551603009245 4.25468426234362 0.00047603858088241 0.713861776982813 0.716223171092836 0.000664803873285501 0.000666849796741353 0.000664651187081891 0.998993243574946 NA NA NA 0.999051625482507 99.9934512883142 a11564 PTEN_mut 200 LAQ824 HDAC 8 40 0.0237165266173161 NA -2.68503035728443 -2.6843548204051 -0.000675536879333638 0.548452662481289 1.52618997878488 0.000475238121818776 0.00123171410323254 0.000442629612776967 0.999026254460792 NA NA NA 0.998272493556037 99.9934512883142 a11565 BRCA1_mut 310 YM201636 FYV1 4 45 1.63315443905142 NA 2.41525482040574 2.4146152761011 0.000639544304636974 1.16144478143777 1.01455100229761 0.000624215666313757 0.000550645467488584 0.000630371763655675 0.999050482595716 NA NA NA 0.999208853847494 99.9934512883142 a11566 gain_cnaBRCA12_(TERT) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 9 39 2.77258872223978 NA -0.436024178755392 -0.436643283719154 0.000619104963761608 1.42755309827114 1.41664345756563 0.000436436047010085 0.000433682617137943 0.000437022428230094 0.999063444753134 NA NA NA 0.999082370160946 99.9934512883142 a11567 ARID1A_mut 1009 ATRA Retinoic acid and retinoid X receptor agonist 5 40 2.30258509299405 NA 4.10651992226379 4.10590224025107 0.000617682012726384 0.782672691959742 1.1992142501263 0.000529400994516005 0.000789195814638381 0.000515072275584893 0.999114662780061 NA NA NA 0.998807586791666 99.9934512883142 a11568 loss_cnaBRCA42 184 BMS-754807 IGF1R 3 45 0.940007258491471 NA 1.62791721439088 1.62679907069914 0.00111814369173246 0.590105204307059 1.72476122053757 0.000661102621120764 0.00189482092950776 0.000648288979609575 0.999120177620049 NA NA NA 0.998014025816342 99.9934512883142 a11569 gain_cnaBRCA19 1026 17-AAG HSP90 3 40 0 NA -0.897300149101851 -0.896124637810151 -0.00117551129170079 1.52418438611603 1.81470264448894 0.000652475243092695 0.000771239557634008 0.000647770749257846 0.999135604431393 NA NA NA 0.99908287183982 99.9934512883142 a11570 loss_cnaBRCA22_(SYNCRIP,ZNF292) 17 Cyclopamine SMO 3 10 2.77258872223978 NA 4.69525275832254 4.69575658323092 -0.000503824908386186 0.181550135102238 0.936263127563565 0.000592447560362168 0.00277512824819691 0.000538123198013028 0.999298024428769 NA NA NA 0.998749753237993 99.9934512883142 a11571 ARID1A_mut 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 4 39 1.6094379124341 NA 2.86742789850276 2.86801342240431 -0.00058552390155775 1.77483658834061 1.40949758835441 0.000406789684719459 0.000329902992424326 0.000415413198571946 0.99938554491124 NA NA NA 0.999525507333319 99.9934512883142 a11572 gain_cnaBRCA16 1026 17-AAG HSP90 14 29 0 NA -0.895921622088634 -0.896344250016231 0.000422627927597397 1.00576333893332 2.06958140576965 0.000234582397885652 0.000420206137206811 0.000204209376069567 0.999428368229146 NA NA NA 0.999285360469396 99.9934512883142 a11573 gain_cnaBRCA10_(MDM2,NUP107) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 3 40 -1.38629436111989 0.693147180559945 -2.22081093892279 -2.22048866603659 -0.000322272886206232 0.906174424891946 0.963253570383549 0.000335509432015931 0.000355641118700365 0.000334567030027108 0.999555518906499 NA NA NA 0.999574523204826 99.9934512883142 a11574 loss_cnaBRCA38 170 Shikonin unknown 4 43 2.77258872223978 NA 0.00330831130489984 0.00363588579029839 -0.000327574485398547 0.739285501071156 1.22196467593472 0.000273923178980202 0.000443096050069861 0.000268071976096998 0.999584212364663 NA NA NA 0.999401113822919 99.9934512883142 a11575 gain_cnaBRCA8_(CHD4,WNK1) 303 PIK-93 PI4K, PI3K 4 45 2.99573227355399 NA 2.79118919328031 2.79155724467979 -0.000368051399481484 1.6079373509989 1.41973685532171 0.00025693146924734 0.000228896604244462 0.000259239166822985 0.999609172014912 NA NA NA 0.999671293270258 99.9934512883142 a11576 gain_cnaBRCA19 1061 SB590885 BRAF 3 39 1.6094379124341 NA 4.01175359921183 4.01192385773811 -0.0001702585262775 0.343556556943345 1.12314617720964 0.000155147237383001 0.000495576413363512 0.000151590709857993 0.999794676654971 NA NA NA 0.999511957609071 99.9934512883142 a11577 loss_cnaBRCA23 1129 PF-4708671 RPS6KB1 (p70S6KA) 3 40 2.30258509299405 NA 3.80910829497304 3.80895632047447 0.000151974498567409 0.624874740344712 1.17540483741421 0.000131618886902238 0.000243207940336286 0.000129295451005408 0.999825631997649 NA NA NA 0.999723403050491 99.9934512883142 a11578 MLL3_mut 1375 Temozolomide DNA akylating agent 3 43 3.40119738166216 NA 5.9001902847924 5.9001214459252 6.88388672012152e-05 0.618804199996864 0.707370742782911 9.78398942036335e-05 0.000111244990259543 9.73165315410021e-05 0.999870011598477 NA NA NA 0.999867148765603 99.9934512883142 a11579 BRCA2_mut 275 I-BET BRD2, BRD3, BRD4 6 43 2.99573227355399 NA 4.03898427171382 4.03893502969708 4.92420167441665e-05 1.03581595102964 1.40381342517276 3.59595211142679e-05 4.75393497225238e-05 3.50773228558536e-05 0.999934512883142 NA NA NA 0.999919703920249 99.9934512883142